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1

Benali, Tahar. "Optimisation énergétique des procédés : application à la distillation atmosphérique du pétrole." Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0085.

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L'objectif de cette étude consiste à développer une approche permettant d'économiser de l'énergie de haut niveau thermique dans le procédé de la distillation atmosphérique du pétrole. Cette approche repose sur le fait que l'installation de plusieurs flashs sur le train de préchauffage de ce procédé associée à un choix approprié du plateau d'alimentation des vapeurs résultantes à la colonne de distillation, provoque une diminution de la chaleur apportée à ce train de préchauffage. Le déficit de chaleur de haut niveau thermique ainsi créé est causé par la réduction des débits des reflux latéraux
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2

Remez, Vinogradov Nikita 1985. "Drug design at biological systems level." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/396352.

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The explosion of reductionist approaches at the end of the XXth century allowed for fast and high-throughput data collection in pharmaceutical industry, but did not deliver the expected gain in drug discovery performance. Omics methodologies were able to provide large amounts of information on one-to-one cause-effect relationships, but could not explain some of the complex effects in living organisms and biological systems in general. This Thesis, performed in the premises of an emerging biotech company, represents an attempt to explore the impact of an integrative systems approach to
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3

Stoops, Robbin Lynn. "Creation of a collegiate level drug testing policy." Thesis, Virginia Tech, 1988. http://hdl.handle.net/10919/45194.

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The NCAA, in order to preserve fair and equal competition in intercollegiate athletics, created a drug testing program. In 1987 and again in 1988, student-athletes at two separate universities challenged the NCAA’s drug testing program in a court of law. As a result, constitutional questions pertaining to a student-athlete’s individual rights have surfaced. The purpose of the research was to create a collegiate level drug testing policy to be utilized during the regular season by NCAA Division I member institutions. A drug testing program, based upon individual reasonable suspicion, was creat
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4

García, Martín Meráz. "A theoretical approach : an exploratory analysis of higher level narcotraffickers of Latin American decent." Online access for everyone, 2007. http://www.dissertations.wsu.edu/Dissertations/Fall2007/M_Garcia_082007.pdf.

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5

Scheckler, Rebecca Klein. "Predicting drug interactions with a three level causal model." Thesis, Virginia Tech, 1990. http://hdl.handle.net/10919/42156.

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A medical expert system for predicting qualitative pharmacodynamic interactions of the cardiovascular system is described. TLCM traces causal paths of drug action through up to three levels of drug action. The three levels which are molecular/receptor level, physiological level and clinical level provide both deep and shallow reasoning in order to overcome the problem of unknowns in medical expert systems. Sparsity of information in pharmacology results from necessity of using non-invasive techniques for monitoring drug effects in the human subject and difficulty in isolating effect from feedb
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6

Walter, Sandra M. "Examining the effects of drug testing on drug use at the secondary education level." Virtual Press, 1997. http://liblink.bsu.edu/uhtbin/catkey/1048380.

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The primary purpose of this study was to determine if a drug testing program could impact or change student drug use at the secondary education level. Secondary purposes were to 1) assess the perceptions of secondary education students toward licit and illicit drugs, drug use, and the newly implemented drug testing program, and 2) to examine why drug use may continue even after a drug testing program has been implemented. Data was collected through the use of questionnaires, discussion groups, and one-on-one interviews. Examination of the questionnaire data indicated that student drug use was
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7

Beyer, Lorraine R. "Heroin importation and higher level drug dealing in Australia : opportunistic entrepreneurialism /." Connect to thesis, 2005. http://eprints.unimelb.edu.au/archive/00001612.

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8

Bell, D. C. "Studies on the use of models for the investigation of shearer drum dust generation." Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356136.

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9

Atkins, Carina T. "Initial Drug Court Risk Assessment Scores and Probationers' Completion of Drug Court Programs." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5823.

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Drug offenders continue to cost citizens and governments money, while drug courts attempt to rehabilitate offenders and reduce recidivism. The Level of Service Inventory-Revised (LSI-R) is a risk assessment tool used by courts and probation offices to determine needs and risks of offenders, and often determine levels of supervision. The purpose of this quasi experimental study was to determine if there is a statistically significant association between the initial LSI-R scores of offenders entering drug courts and their successful completion of the drug court program. Therapeutic jurisprudence
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10

Hyttinen, L. (Laura). "Long-term effects of the cholesterol level and its drug treatment." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514296222.

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Abstract Increased plasma cholesterol is a well-known risk factor for cardiovascular diseases in middle and early old age. At older ages, this association seems to disappear. Very few studies have assessed the impact of the lifelong cholesterol burden on old age, the purpose of this thesis. Study populations consisted of 1) old persons with familial hypercholesterolemia (FH), a genetic disorder associated with an increased risk of coronary heart disease (CHD) if untreated, and 2) initially healthy men (The Helsinki Businessmen Study, HBS) followed-up from midlife to old age. A population-based
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11

Mira, Martínez Sofía. "A new mechanism of antimalarial drug resistance regulated at the epigenetic level." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/523484.

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Malaria is responsible of almost half a million deaths every year. Currently, campaigns for the control and elimination of malaria are implemented in malaria endemic areas. However, drug resistance is one of the major impediments to achieve malaria elimination. In this thesis we have investigated how P. falciparum parasites develop resistance to some toxic compounds by functional variation linked to epigenetic regulation of clag3 genes. These genes present clonally variant expression and determine the formation of the main channel for the transport of solutes at the membrane of the infected R
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12

Bester, Margaretha. "Defining mechanisms that determine the levels of drug resistance in Mycobacterium tuberculosis." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/4610.

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Thesis (MSc (Biomedical Sciences. Molecular Biology and Human Genetics))--University of Stellenbosch, 2009.<br>ENGLISH ABSTRACT: Varying levels of Rifampicin (RIF) resistance in closely related clinical Mycobacterium tuberculosis isolates and in vitro generated mutants question the dogma that non-synonymous single nucleotide polymorphisms in the rpoB gene are the only mechanism explaining RIF resistance. This study aimed to identify biological mechanisms that define the level of RIF resistance in two closely related clinical M. tuberculosis isolates using proteomic, transcriptomic and genomic
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13

Purcell, Gregory Mark. "Intervention to improve the level of documentation of antipsychotic related adverse drug reactions." Thesis, Nelson Mandela Metropolitan University, 2014. http://hdl.handle.net/10948/10340.

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Antipsychotic drugs are the mainstay of treatment for psychotic disorders according to the Standard Treatment Guidelines (2012). However, these drugs are associated with multiple severe adverse drug reactions. In order to limit the effect of adverse drug reactions on patient care, documentation is necessary. Documentation of adverse drug reactions entails recording the reaction experienced, as well as supplementary information. Proper documentation can prevent future occurrences of the same or similar adverse drug reactions. The aim of this study was to determine the effects of an educational
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14

Orrick, Erin Anderson. "Assessing the city-level impact of drug courts on crime rates, 1985-2000." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/2557.

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Thesis (M.A.) -- University of Maryland, College Park, 2005.<br>Thesis research directed by: Dept. of Criminology and Criminal Justice. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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15

Ikeanyi, Chinonyelum. "Gastric-resident drug delivery system for prolonged gram-level dosing of Tuberculosis treatment." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/123290.

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Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 31-32).<br>Medication non-adherence is one of the biggest challenges facing effective treatment of disease around the world. In developing and developed countries, approximately 50-70% of patients fail to correctly follow the drug regimen prescribed by their health care providers. Gastric resident systems have the potential to improve medication non-adherence as they enable more infrequent dosing, a key recognized
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16

Sablay, Hyder. "Prescribing practice at a tertiary level paediatric hospital in South Africa." University of the Western Cape, 2014. http://hdl.handle.net/11394/4357.

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Magister Pharmaceuticae - MPharm<br>The objectives of the present study were to describe the type and frequency of prescribing errors and error frequency, to determine the error frequency for different drug classes, to identify potential drug interactions and drug-disease interactions to point out off-label prescribing and to evaluate risk factors of prescribing errors. Methods: This prospective cross sectional study was conducted over a period of 6 months from July 2012 to December 2012 in 2 specialist wards and 2 general medical wards at Red Cross War Memorial Children’s Hospital in Cape Tow
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17

Linck, Marcelo Melo. "Increasing memory access efficiency through a two-level memory controller." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2018. http://tede2.pucrs.br/tede2/handle/tede/7941.

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Submitted by PPG Ci?ncia da Computa??o (ppgcc@pucrs.br) on 2018-04-03T14:30:24Z No. of bitstreams: 1 MARCELO_MELO_LINCK_DIS.pdf: 4153250 bytes, checksum: 821a8f1e65f49c1b24a0b69b4f6e7f94 (MD5)<br>Approved for entry into archive by Tatiana Lopes (tatiana.lopes@pucrs.br) on 2018-04-12T21:09:45Z (GMT) No. of bitstreams: 1 MARCELO_MELO_LINCK_DIS.pdf: 4153250 bytes, checksum: 821a8f1e65f49c1b24a0b69b4f6e7f94 (MD5)<br>Made available in DSpace on 2018-04-12T21:23:08Z (GMT). No. of bitstreams: 1 MARCELO_MELO_LINCK_DIS.pdf: 4153250 bytes, checksum: 821a8f1e65f49c1b24a0b69b4f6e7f94 (MD5) Previous issu
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18

Shoemaker, David R. (David Robert). "A performance measure of page mode dram as a second level cache in microprocessors." Thesis, Massachusetts Institute of Technology, 1992. http://hdl.handle.net/1721.1/60734.

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19

Luu, Huong T. T. "USING PRESCRIPTION DRUG MONITORING DATA TO INFORM POPULATION LEVEL ANALYSIS OF OPIOID ANALGESIC UTILIZATION." UKnowledge, 2018. https://uknowledge.uky.edu/epb_etds/21.

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Increased opioid analgesic (OA) prescribing has been associated with increased risk of prescription opioid diversion, misuse, and abuse. States established prescription drug monitoring programs (PDMPs) to collect and analyze electronic records for dispensed controlled substances to reduce prescription drug abuse and diversion. PDMP data can be used by prescribers for tracking patient’s history of controlled substance prescribing to inform clinical decisions. The studies in this dissertation are focused on the less utilized potential of the PDMP data to enhance public health surveillance to mon
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20

Bonomo, Elizabeth. "Sanctionable Behavior in a Felony Level Drug Court: Categorizing Noncompliant Behavior Through a Criminal-Thinking Lens." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/cj_theses/5.

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Drug courts use sanctions as a form of behavior management and modification, and they are an important structural tool in the treatment of drug offenders by the criminal justice system. This research examined noncompliant behavior being sanctioned in a felony level drug court. The sample consisted of 66 high risk/high needs individuals who were enrolled in a drug court over a two-year period. Sanctionable behaviors were analyzed through a criminal-thinking framework in order to better understand noncompliant behavior in drug court. This study finds support for applying a criminal-thinking
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21

Prisbrey, Erin D. "Evaluating Counseling Modality Based on Recidivism for Misdemeanor Offenders." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7059.

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Illegal substance use in the United States is a growing problem, and a western state has a higher than average rate of drug offenders. Many courts, including misdemeanor courts, have limited to no budget for drug treatment programs outside of the drug court treatment programs. As such, many court-ordered drug treatment programs, when drug counseling is ordered in exchange for a reduction in charges, are outsourced to privately owned companies. The drug counseling entails a single 8-hour outsourced drug counseling course, which includes either in-person, online, or correspondence-based counseli
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22

Williams, Ashley E. "Measuring the Level of University Student Knowledge on the U.S. Drug Policy and Harms Associated with Illicit Drug Use: A Replication Study." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/honors/256.

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The purpose of this thesis project is to measure the level of knowledge that university students have regarding state and national illicit drug classifications in the United States and associated penalties with these classifications, as well as the harms resulting from consuming illicit drugs. This particular study, which is to be conducted as a replication study to Higson’s campus-based study on the UK drug policy, focuses on a different campus population in regards to the U.S. drug policy. Replication studies such as these are beneficial to previous studies because such additional research w
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23

Hameed, Fazal [Verfasser], and J. [Akademischer Betreuer] Henkel. "DRAM Aware Last-Level-Cache Policies for Multi-core Systems / Fazal Hameed. Betreuer: J. Henkel." Karlsruhe : KIT-Bibliothek, 2015. http://d-nb.info/1077251165/34.

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24

Morgan, Susan. "Evaluating public policy at a local level : the case of drug treatment and testing orders." Thesis, Swansea University, 2007. https://cronfa.swan.ac.uk/Record/cronfa42889.

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This research set out to identify issues, circumstances, perspectives and constraints contributing to the extent to which a centrally-driven UK policy initiative, of Drug Treatment and Testing Orders (DTTOs) for drug misusing offenders, has been implemented in a particular location. The setting for the research has been in South Wales, and the approach employed has been to use a stakeholder, pluralistic evaluation framework to conduct a naturalistic enquiry of the policy implementation process. Policy formulation was identified as a complex process that had to be planned and implemented within
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25

Paraiso, Kim H. T. "Utilizing Systems Level Approaches to Identify Key Mechanisms of Drug Resistance in BRAF Mutated Melanoma." Scholar Commons, 2015. https://scholarcommons.usf.edu/etd/5552.

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In the last four years, seven new drugs have been FDA approved for the treatment of late stage melanoma, for the field of melanoma, this marks an incredibly exciting. Three of these new therapies, vemurafenib, dabrafenib and trametinib are small molecule kinase inhibitors that target the MAPK pathway and as such have been approved for the treatment of BRAFV600 mutant melanomas. Yet despite recent advances, mechanisms of intrinsic and acquired BRAF inhibitor resistance continue to undermine uniform and long-lasting therapeutic responses. Several studies have shown that the reactivation of MAPK
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26

Mackie, Claire Elisabeth. "The use of microdialysis to investigate the pharmacokinetics and tumour uptake of drugs in rats." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324913.

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27

Bonakdar, Mohammad. "Microdevices for Investigating Pulsed Electric Fields-Mediated Therapies at Cellular and Tissue Level." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/81384.

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Recent attempts to investigate living systems from a biophysical point of view has opened new windows for development of new diagnostic methods and therapies. Pulsed electric fields (PEFs) are a new class of therapies that take advantage of biophysical properties and have proven to be effective in drug delivery and treating several disorders including tumors. While animal models are commonly being used for development of new therapies, the high cost and complexity of these models along with the difficulties to control the electric field in the animal tissue are some of the obstacles toward the
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28

Frankel, Ronald Evan. "Levels of dependence : a drug rehabilitation facility for mothers and their children." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/66373.

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Thesis (M. Arch.)--Massachusetts Institute of Technology, Dept. of Architecture, 1996.<br>Includes bibliographical references (p. 71-73).<br>Contemporary society is faced with an increasing problem of substance abuse and addiction. The public consequences of this private problem are experienced in the increasing costs in the healthcare, penal and welfare systems as well as the less tangible effects drugs and addiction have on the quality of our urban centers. Current efforts to solve this problem include education, substance abuse treatment and curtailing the availability of drugs. Although th
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Neville, John B. "The impact of low and middle level policing on the social organisation of the drug scene." Thesis, Loughborough University, 1997. https://dspace.lboro.ac.uk/2134/26799.

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30

Pritchard, Justin (Justin Robert). "Systems level characterizations of single and combination drug mechanisms of action in vitro and in vivo." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/72635.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2012.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student submitted PDF version of thesis.<br>Includes bibliographical references.<br>Small molecule characterization is a critical limiting step in cancer drug development. At the present time, high throughput screens of natural products and combinatorial synthesis libraries generate more pharmaceutical leads than can be characterized in detail. Lead
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31

Hagens, Werner Ivo. "Arming drug carriers to disable the Hepatic Stellate Cell the targeted delivery of apoptosis-inducing drugs to the fibrotic liver /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2006. http://irs.ub.rug.nl/ppn/297591126.

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32

Tolle, Kristin M., Hsinchun Chen, and Hsiao-Hui Chow. "Estimating drug/plasma concentration levels by applying neural networks to pharmacokinetic data sets." Elsevier, 2000. http://hdl.handle.net/10150/105955.

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Artificial Intelligence Lab, Department of MIS, University of Arizona<br>Predicting blood concentration levels of pharmaceutical agents in human subjects can be made difficult by missing data and variability within and between human subjects. Biometricians use a variety of software tools to analyze pharmacokinetic information in order to conduct research about a pharmaceutical agent. This paper is the comparison between using a feedforward backpropagation neural network to predict blood serum concentration levels of the drug tobramycin in pediatric cystic fibrosis and hemotologicâ oncologic d
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33

Satterwhite, Stuart C. "Development of a model to predict drug use at the local command level in the U.S. Navy." Monterey, California. Naval Postgraduate School, 1997. http://hdl.handle.net/10945/8261.

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Approved for public release; distribution is unlimited<br>The primary objective of this thesis is to develop a model that predicts the threat of drug use at the local command level. The model is developed from two surveys: (a) the National Household Survey on Drug Abuse (U.S. Department of Health and Human Services), and (b) the 1995 Department of Defense Survey of Health Related Behaviors Among Military Personnel. This predicting technique is applied to specific Navy commands from data obtained from the Defense Manpower Data Center (West) on each command's demographic profile. The results sho
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34

Phillips, Chelsea E., Alea S. Moore, Caralyn I. Snyder, Whitney P. Varney, and Nicholas E. Hagemeier. "Pharmacy-Related Ambulatory Care Sensitive Conditions: An Analysis of Tennessee’s County-Level Characteristics." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/1459.

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Objectives: 1) To determine 2010 pharmacy-related ambulatory care sensitive condition (ACSC) hospital discharges by Tennessee (TN) county; 2) To explore pharmacy-related ACSC hospital discharges across county characteristics for Tennessee counties, including community pharmacies per county, age, and county rurality; 3) To explore pharmacy-related ACSC hospital discharges across age for northeastern Tennessee counties. Methods: Data were obtained from the TN Department of Health Statistics (hospital discharge data), TN Board of Pharmacy (licensed community pharmacies), the United States (US) Ce
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Ställberg, Björn. "Asthma in Primary Care : Severity, Treatment and Level of Control." Doctoral thesis, Uppsala universitet, Allmänmedicin och klinisk epidemiologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9332.

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Aims. The overall aim was to examine the severity, treatment and level of control in patients with asthma in primary care in Sweden. The specific aims were to assess what matters to asthma patients, evaluate symptoms, medication and identify factors related to asthma severity, compare the extent of asthma control in 2001 and 2005, and investigate the development of asthma and degree of asthma control in adolescents and young adults who had reported asthma six years earlier. Methods. The first study was a telephone interview of a representative sample of Swedish asthmatics. In the second study
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DE, FELICE BEATRICE. "MULTI-LEVEL TOXICITY ASSESSMENT OF DIFFERENT EMERGING CONTAMINANTS TOWARDS AQUATIC AND TERRESTRIAL MODEL ORGANISMS." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/822571.

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In recent years, emerging contaminants have attracted the attention of scientific community because of their occurrence and potential hazard towards natural ecosystems. Among emerging contaminants, three major classes of molecules can be identified: pharmaceuticals and personal care products (PPCPs), illicit drugs and microplastics (MPs). After anthropic use, these contaminants enter the environment through several routes, such as the sewage systems or direct input, resulting in a widespread contamination of atmosphere, water, soil and biota. Although the presence of these molecules is well-kn
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Yuan, Xiaoda. "A Molecular-Level View of the Physical Stability of Amorphous Solid Dispersions." UKnowledge, 2015. http://uknowledge.uky.edu/pharmacy_etds/51.

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Many pharmaceutical compounds being developed in recent years are poorly soluble in water. This has led to insufficient oral bioavailability of many compounds in vitro. The amorphous formulation is one of the promising techniques to increase the oral bioavailability of these poorly water-soluble compounds. However, an amorphous drug substance is inherently unstable because it is a high energy form. In order to increase the physical stability, the amorphous drug is often formulated with a suitable polymer to form an amorphous solid dispersion. Previous research has suggested that the formation
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38

Clansy, Pauline Amos. "The effect of high and low anxiety on level of motivation, length of stay in treatment, and intrapsychic focus of attention in Veterans Administration drug-abuse patients." Virtual Press, 1985. http://liblink.bsu.edu/uhtbin/catkey/458525.

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The purpose of this study was to examine the effect of high and low anxiety on motivation for treatment, length of stay in treatment, and intrapsychic focus of attention in Veterans Administration drug-abuse patients. The dependent variables were measured by the Minnesota Multiphasic Personality Inventory (MMPI), Reasons For Seeking Treatment Inventory (RFST), State Trait Anxiety Inventory (STAI), Psychopathic State Inventory (PSI), and the total number of days each subject participated in the treatment program. The major hypothesis was stated in the null form.The PSI and the STAI were used to
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Heaton, G. D. "The effects of high dietary levels of saccharin on in vivo and in vitro drug metabolism." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233722.

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40

Ward, Elizabeth Anne. "Effects of Length of Time in Treatment and Criminal Classification Level on Recidivism Following Residential Treatment Programs for Drug Offenders." Thesis, Virginia Tech, 2008. http://hdl.handle.net/10919/32084.

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One aim of residential drug treatment programs for drug offenders released from prison is to reduce recidivism rates for these offenders. However, research on this topic has shown mixed results on the effectiveness of such programs, and all of the factors that influence whether an individual will recidivate are still unclear. This study explored the relationship between criminal classification levels of drug offenders and the length of time spent in residential treatment and the effects that this relationship had on drug offendersâ odds of recidivism. Data from case history records of dru
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Saeedi, Baharak. "Characterization of clinical enterococcal isolates in Swedish hospitals : studies on genetic relatedness and high-level gentamicin resistance /." Linköping : Dept. of Molecular and Clinical Medicine, Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med899s.pdf.

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42

Bhattacharya, Tanmoy. "PRICE LEVELS AND DISPERSION WITH ASYMMETRIC INFORMATION." UKnowledge, 2011. http://uknowledge.uky.edu/economics_etds/2.

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In the extensive literature on price dispersions that exists to date, there is a gap in the analysis of how market structure affects prices as well as the degree of dispersion in prices. Specifically, the literature is deficient in analyzing how price levels and price dispersion are affected by the number of firms operating in a market. I use secondary data to look at the prices of prescription drugs at the retail level in nine hundred and seventy pharmacies across one hundred and sixty five markets in Maryland and compare price dispersion across these brick and mortar pharmacies as well as ac
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43

Mauff, Katya. "Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves." Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/10719.

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This thesis discusses the techniques involved in the fitting of nonlinear mixed effect (NLME) models. In particular, it looks at the application of these techniques to the analysis of concentration-time data for the aforementioned antimalarial compounds, and details the necessary extensions to the basic modeling process that were required in order to accommodate multiple responses and multiple observation phases (pregnant and postpartum).
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Machethe, K. F. "The level of antiretroviral drug resistance at Nkensani Hospital Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome Treatment Site." Thesis, University of Limpopo, 2014. http://hdl.handle.net/10386/1227.

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45

Kursungoz, Canan. "Determination Of Hypothalamic Neuropeptide Levels Involved In Appetite Regulation In Atypical Antipsychotic Drug, Risperidone Treatment." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614581/index.pdf.

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Although the use of atypical antipsychotic drugs is successful in the treatment of schizophrenia, they cause complications in the long term use that is mainly weight gain. In this study, circulating levels of hypothalamic neuropeptides/hormones, which are related to appetite regulation<br>neuropeptide Y (NPY), alpha melanocyte stimulating hormone (&alpha<br>-MSH), cocaine and amphethamine regulated transcript (CART) and plus leptin in male schizophrenic patients who were treated with an atypical antipsychotic drug, risperidone, which is a serotonin antagonist, for 4 weeks was investigated. Bas
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STRATTON, TIMOTHY PATRICK. "COMPREHENSION AND READABILITY OF DRUG INFORMATION: A COMPARATIVE STUDY AT DIFFERENT LEVELS OF READING ABILITY." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183988.

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Ley's Partial Model of Compliance suggests that patients who understand information given to them are more likely to remember the information and are more likely to be satisfied with the information. The model then suggests that these components will lead to greater patient compliance with medication regimens. To test the model, Patient Package Inserts (PPIs) describing thiazide diuretics from the American Association of Retired Persons, the American Medical Association, the Canadian Pharmaceutical Association, the Food and Drug Administration, the National Association of Retail Druggists, the
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47

Pak-Archer, Monalisa. "A comparison of the level of substance abuse training and professional school counselors' attitudes, treatment approaches, and personal competencies assessing alcoholism." online access from Digital Dissertation Consortium, 2005. http://libweb.cityu.edu.hk/cgi-bin/er/db/ddcdiss.pl?3183153.

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Almarhoon, Zahra M. B. S. "Geographic Variation in the Utilization of Antihyperglycemic Therapies in the U.S. Medicaid Program at State-Level Using Geographic Information System." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1553618550167677.

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Dukpa, Lhundup. "Using the writing process model to teach writing at the junior high school level in Druk Yul, an action research." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq23789.pdf.

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BARONCHELLI, SIMONA. "Cytogenetic, genimic, epigenomic and drug sensitivity landscapes to unravel the complexity of glioma stem cell lines: a multi-level approach." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/27138.

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BACKGROUND. Glioblastoma multiforme (GBM) is the most common and malignant type of glioma and it is characterized by extensive heterogeneity, both at the cellular and molecular level. The poor prognosis and the lack of an effective treatment are due to the presence of a small sub-population of cells with stem-like properties, termed glioma stem cells (GSCs). At the genomic level, heterogeneity is characterized by multiple levels of alterations, including cytogenetic, genomic and epigenomic alterations. Drug sensitivity is an additional level of GSC complexity and heterogeneity and the identifi
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