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Journal articles on the topic 'Drusen'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Shchuko, A. G., D. Yu Samsonov, S. I. Zhukova, et al. "Differential Change in Retina Structure and Function in Children and Adolescents with Drusens of the Optic Nerve Disk." Ophthalmology in Russia 15, no. 2S (2018): 73–81. http://dx.doi.org/10.18008/1816-5095-2018-2s-73-81.

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The first histological and clinical description of the optic nerve drusens was given in the 19th century. Then authors considered drusens as congenital pathologies, and a study of 1999 showed that drusen is not the primary pathology, but the dysplasia of the optic nerve disk and its circulation predisposes to the formation of drusen. Central vision in patients with drusens of the optic nerve disc is reduced rarely, and their diagnosis is reduced to ascertaining of the fact of having drusen without taking into account the structural and functional changes in the visual system.Purpose of the wor

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Schlanitz, Ferdinand, Bernhard Baumann, Stefan Sacu, et al. "Impact of drusen and drusenoid retinal pigment epithelium elevation size and structure on the integrity of the retinal pigment epithelium layer." British Journal of Ophthalmology 103, no. 2 (2018): 227–32. http://dx.doi.org/10.1136/bjophthalmol-2017-311782.

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PurposeTo evaluate the impact of drusen size and structure on retinal pigment epithelium (RPE) and photoreceptor layers in eyes with early to intermediate age-related macular degeneration (AMD) using polarisation-sensitive optical coherence tomography (OCT).DesignRetrospective investigation of an observational cross-sectional study.ParticipantsPatients with early to intermediate AMD.MethodsTwenty-five eyes of 25 patients with drusen were imaged with polarisation-sensitive OCT using macular volume scans. Each scan was manually graded for six distinct drusen characteristics and the integrity of

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Čmelo, Jozef, Jela Valášková, and Vladimír Krásnik. "Optic Disc Drusen and Heamodynamics." Czech and Slovak Ophthalmology 75, no. 5 (2019): 252–56. http://dx.doi.org/10.31348/2019/5/2.

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Purpose: The problem of optic disc drusen (ODD) has been described in detail in several publications. However, less attention has been devoted to real haemodynamic parameters (HP) in ODD. It has been clinically demonstrated that the occurrence and progression of changes in the visual field in ODD are closely linked with the haemodynamics of the vascular supply of the eye – the optic nerve. ODD may visually overlap excavation of the disc of the optic nerve, on the basis of which it is more difficult to evaluate changes (scotomas) in the visual field in the case of glaucoma. Methods: Haemodynami

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Muth, Daniel Rudolf, Mario Damiano Toro, Anahita Bajka, et al. "Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification." Biomedicines 10, no. 10 (2022): 2370. http://dx.doi.org/10.3390/biomedicines10102370.

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Background: To investigate associations and predictive factors between macular neovascularization (MNV) lesion variants and drusen types in patients with treatment-naïve neovascular age-related macular degeneration (AMD). Methods: Multimodal imaging was retrospectively reviewed for druse type (soft drusen, subretinal drusenoid deposits (SDDs) or mixed) and MNV type (MNV 1, MNV 2, MNV 1/2 or MNV 3). The Consensus on Neovascular AMD Nomenclature (CONAN) classification was used for characterizing MNV at baseline. Results: One eye of each eligible patient was included (n = 191). Patients with pred

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Sitaula, S., M. Thapa, and AK Sharma. "Optic disc drusen presenting as papilledema: a case report." Journal of Chitwan Medical College 4, no. 1 (2014): 42–44. http://dx.doi.org/10.3126/jcmc.v4i1.10848.

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Optic disc drusens, which are congenital anomalies of optic nerve head, are depositions of mucopolysaccharides and proteinaceous material within the optic nerve head. They are usually bilateral and diagnosed incidentally during routine fundus examination where they may be mistaken for papilledema. We report a case of 63 year old female referred to the neuro-ophthalmology department with the clinical suspicion of disc edema. Simple noninvasive investigations like ultrasound B-scan, fundus autofluorescene along with the newer test like spectral domain optical coherence tomography helped us to d

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6

Gartner, S. "Drusen." Archives of Ophthalmology 103, no. 9 (1985): 1283. http://dx.doi.org/10.1001/archopht.1985.01050090035020.

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7

Belmouhand, Mohamed, Simon P. Rothenbuehler, Sami Dabbah, et al. "Small hard drusen and associated factors in early seniority." PLOS ONE 17, no. 12 (2022): e0279279. http://dx.doi.org/10.1371/journal.pone.0279279.

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Purpose The purpose of this study was to examine the ocular and systemic risk profile of the fundus phenotype ≥ 20 small hard (macular) drusen (< 63 μm in diameter). Methods This single-center, cross-sectional study of 176 same-sex twin pairs aged 30 to 80 (median 60) years was a component of a framework study of the transition from not having age-related macular degeneration to having early AMD. Drusen categories assessed using fundus photography and optical coherence tomography included small hard drusen (diameter < 63 μm), intermediate soft drusen (63–125 μm), and large soft drusen (&

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Ban, Norimitsu, Ari Shinojima, Kazuno Negishi, and Toshihide Kurihara. "Drusen in AMD from the Perspective of Cholesterol Metabolism and Hypoxic Response." Journal of Clinical Medicine 13, no. 9 (2024): 2608. http://dx.doi.org/10.3390/jcm13092608.

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Drusen are one of the most characteristic pathologies of precursor lesion of age-related macular degeneration (AMD). Drusen comprise a yellowish white substance that accumulates typically under the retinal pigment epithelium (RPE), and their constituents are lipids, complement, amyloid, crystallin, and others. In the past, many researchers have focused on drusen and tried to elucidate the pathophysiology of AMD because they believed that disease progression from early AMD to advanced AMD might be based on drusen or drusen might cause AMD. In fact, it is well established that drusen are the hal

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9

D’souza, Yvonne, Carolyn J. P. Jones, and Richard Bonshek. "Glycoproteins of drusen and drusen-like lesions." Journal of Molecular Histology 39, no. 1 (2007): 77–86. http://dx.doi.org/10.1007/s10735-007-9130-5.

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BONSHEK, RE, Y. D'SOUZA, and C. JONES. "Glycoproteins of drusen and drusen-like lesions." Acta Ophthalmologica Scandinavica 85 (October 2, 2007): 0. http://dx.doi.org/10.1111/j.1600-0420.2007.01062_3305.x.

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11

Pham, Quang T. M., Sangil Ahn, Su Jeong Song, and Jitae Shin. "Automatic Drusen Segmentation for Age-Related Macular Degeneration in Fundus Images Using Deep Learning." Electronics 9, no. 10 (2020): 1617. http://dx.doi.org/10.3390/electronics9101617.

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Drusen are the main aspect of detecting age-related macular degeneration (AMD). Ophthalmologists can evaluate the condition of AMD based on drusen in fundus images. However, in the early stage of AMD, the drusen areas are usually small and vague. This leads to challenges in the drusen segmentation task. Moreover, due to the high-resolution fundus images, it is hard to accurately predict the drusen areas with deep learning models. In this paper, we propose a multi-scale deep learning model for drusen segmentation. By exploiting both local and global information, we can improve the performance,

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Saßmannshausen, Marlene, Leyla Sautbaeva, Leon Alexander von der Emde, et al. "Retro Mode Imaging for Detection and Quantification of Sub-RPE Drusen and Subretinal Drusenoid Deposits in Age-Related Macular Degeneration." Journal of Clinical Medicine 13, no. 14 (2024): 4131. http://dx.doi.org/10.3390/jcm13144131.

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Background: Drusen and drusenoid deposits are a hallmark of age-related macular degeneration (AMD). Nowadays, a multimodal retinal imaging approach enables the detection of these deposits. However, quantitative data on subretinal drusenoid deposits (SDDs) are still missing. Here, we compare the capability of en-face drusen and SDD area detection in eyes with non-exudative AMD using conventional imaging modalities versus Retro mode imaging. We also quantitatively assess the topographic distribution of drusen and SDDs. Methods: In total, 120 eyes of 90 subjects (mean age ± standard deviation = 7

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Kamao, Hiroyuki, Katsutoshi Goto, Kento Matsuno, Kenichi Mizukawa, Atsushi Miki, and Junichi Kiryu. "Clinical Characteristics of Neovascular Age-Related Macular Degeneration without Typical Drusen." Journal of Ophthalmology 2021 (April 27, 2021): 1–8. http://dx.doi.org/10.1155/2021/6683532.

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Purpose. To evaluate the clinical characteristics of neovascular age-related macular degeneration (nAMD) patients without typical drusen. Methods. We retrospectively studied 165 eyes in 165 patients with treatment-naïve nAMD, including typical AMD and polypoidal choroidal vasculopathy (PCV). According to the fellow eye condition, the patients were divided into nAMD with and without typical drusen groups. Eyes with soft drusen or subretinal drusenoid deposits were classified into the nAMD with the typical drusen group. Smoking status and diagnoses of hypertension and diabetes were identified fr

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Chen, Qing-Shan, Xia Zhao, Miao-Hong Chen, Yu-Hang Yang, and Zhi Li. "Morphological changes of macular soft drusen and drusenoid DPED after subthreshold micropulse laser treatment." International Eye Research 2, no. 2 (2021): 95–100. http://dx.doi.org/10.18240/ier.2021.02.07.

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AIM: To analyze the morphological changes of macular soft drusen and drusenoid pigmental epithelium detachment (DPED) after subthreshold micropulse laser treatment (SMLT). METHODS: Fourteen patients (20 affected eyes) with soft drusen and DPED clinically confirmed from August 2016 to October 2018, were included in this study. 577 nm yellow laser of SMLT was applied for soft drusen and DPED. The changes of soft drusen and DPED in best corrected visual acuity (BCVA)(LogMAR)and height, diameter and cross-sessional area according to fundus autofluorescence and SD-OCT examinations were observed aft

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15

Suzuki, Mihoko, Christine A. Curcio, Robert F. Mullins, and Richard F. Spaide. "REFRACTILE DRUSEN." Retina 35, no. 5 (2015): 859–65. http://dx.doi.org/10.1097/iae.0000000000000503.

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Querques, Giuseppe, and Eric H. Souied. "Vascularized Drusen." Retina 35, no. 12 (2015): 2433–39. http://dx.doi.org/10.1097/iae.0000000000000761.

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Balaratnasingam, Chandrakumar, Svetlana Cherepanoff, Rosa Dolz-Marco, et al. "Cuticular Drusen." Ophthalmology 125, no. 1 (2018): 100–118. http://dx.doi.org/10.1016/j.ophtha.2017.08.033.

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Slotnick, Samantha, and Jerome Sherman. "Disc Drusen." Ophthalmology 119, no. 3 (2012): 652–652. http://dx.doi.org/10.1016/j.ophtha.2011.11.026.

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Tso, M. O. M., and G. A. Fishman. "Drusen-Reply." Archives of Ophthalmology 103, no. 9 (1985): 1283. http://dx.doi.org/10.1001/archopht.1985.01050090035021.

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Sreenivasan, Janani, Praveena Venkatakrishnan, and Charanya Chenthilnathan. "Drusen drizzle." Indian Journal of Ophthalmology 71, no. 8 (2023): 2937. http://dx.doi.org/10.4103/ijo.ijo_3019_22.

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Bennett, Loren Wallace. "Case of Legal Blindness Secondary to Optic Nerve Head Drusen." Canadian Journal of Optometry 84, no. 2 (2022): 23–30. http://dx.doi.org/10.15353/cjo.v84i2.1727.

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Optic nerve head drusen are relatively infrequent abnormalities of the optic disc that are usually discovered as incidental findings during a routine eye examination. While typically considered to be benign, visual field loss due to the drusen is not uncommon. Visual field defects are more prevalent in superficial drusen than buried drusen, and can present as nerve fiber bundle defects, generalized concentric constriction, or enlargement of the blind spot. The extent of damage is variable, but it is rare that the degree of field loss leads to substantial functional impairment. This case presen

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Ukalovic, Kresimir, Sijia Cao, Sieun Lee, et al. "Drusen in the Peripheral Retina of the Alzheimer’s Eye." Current Alzheimer Research 15, no. 8 (2018): 743–50. http://dx.doi.org/10.2174/1567205015666180123122637.

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Background: Recent work on Alzheimer's disease (AD) diagnosis focuses on neuroimaging modalities; however, these methods are expensive, invasive, and not available to all patients. Ocular imaging of biomarkers, such as drusen in the peripheral retina, could provide an alternative method to diagnose AD. Objective: This study compares macular and peripheral drusen load in control and AD eyes. Methods: Postmortem eye tissues were obtained from donors with a neuropathological diagnosis of AD. Retina from normal donors were processed and categorized into younger (<55 years) and older (>55 yea

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Hristova, Elitsa G., and Zornitsa I. Zlatarova. "Dry Age-Related Macular Degeneration – A New Approach In Optical Coherence Tomography Monitoring And Quantitative Assessment." Journal of Biomedical and Clinical Research 7, no. 2 (2014): 148–54. http://dx.doi.org/10.1515/jbcr-2015-0141.

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Summary The purpose of the study was to present the ability of Drusen analysis software tool to measure drusen area and volume in patients with dry age-related macular degeneration (AMD). Eleven patients with confirmed dry AMD aged 59-74 years were scanned with 3D OCT-2000 Topcon 3D Macula scanning protocol by a single operator. All subjects underwent a complete ophthalmologic examination including best corrected visual acuity, indirect biomicroscopy, tonometry, fluorescein angiography and OCT. Drusen analysis was performed on the macula with 6.0 × 6.0 mm volume cube scans and 512×128 pixels s

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Pedersen, Hilde R., Stuart J. Gilson, Alfredo Dubra, Inger Christine Munch, Michael Larsen, and Rigmor C. Baraas. "Multimodal imaging of small hard retinal drusen in young healthy adults." British Journal of Ophthalmology 102, no. 1 (2017): 146–52. http://dx.doi.org/10.1136/bjophthalmol-2017-310719.

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BackgroundSmall hard macular drusen can be observed in the retina of adults as young as 18 years of age. Here, we seek to describe the in vivo topography and geometry of these drusen.MethodsRetinal images were acquired in young, healthy adults using colour fundus photography, spectral domain optic coherence tomography (SD-OCT), reflectance flood-illuminated adaptive optic ophthalmoscopy (AO flood) and reflectance adaptive optic scanning light ophthalmoscopy (AOSLO) in both confocal and non-confocal split-detection modalities. Small bright yellow hard drusen within a 10 degree radius from the f

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Kamao, Hiroyuki, Erika Mitsui, Yuto Date, Katsutoshi Goto, Kenichi Mizukawa, and Atsushi Miki. "Clinical Characteristics of Unilateral Macular Neovascularization Patients with Pachydrusen in the Fellow Eye." Journal of Clinical Medicine 13, no. 13 (2024): 3757. http://dx.doi.org/10.3390/jcm13133757.

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Background/Objectives: To approach the clinical properties of pachydrusen that differ from conventional drusen, we investigated the incidence of macular neovascularization (MNV) in fellow eyes and the treatment outcomes of intravitreal aflibercept (IVA) in MNV eyes of unilateral MNV patients with pachydrusen in the fellow eye. Methods: We retrospectively studied 261 consecutive patients with treatment-naïve unilateral MNV. Patients were classified into four groups according to the type of drusen in the fellow eye: the pachydrusen group (n = 49), the soft drusen group (n = 63), the subretinal d

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Danišová, Jana, and Evžen Fric. "Diagnostics of Optic Disc Drusen in Children with Swept Source OCT Imaging." Czech and Slovak Ophthalmology 77, no. 2 (2021): 80–86. http://dx.doi.org/10.31348/2021/11.

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Aim: The aim of this retrospective study is to compare two methods of optic disc drusen imaging in pediatric patients – new swept source OCT technology with the B-scan ultrasonography, which has been assumed to be a gold standard in diagnosing optic disc drusen, and to compare pRNFL thickness in children with optic disc drusen and control group. Methods: 14 eyes of 8 pediatric patients in whom optic disc drusen were confirmed by either B-scan ultrasonography, or swept-source OCT, were included in the study. We compared the sensitivity of these two imaging methods. Then we compared an average p

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Beck, Marco, Devika S. Joshi, Lieselotte Berger, et al. "Comparison of Drusen Volume Assessed by Two Different OCT Devices." Journal of Clinical Medicine 9, no. 8 (2020): 2657. http://dx.doi.org/10.3390/jcm9082657.

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To compare drusen volume between Heidelberg Spectral Domain (SD-) and Zeiss Swept-Source (SS) PlexElite Optical Coherence Tomography (OCT) determined by manual and automated segmentation methods. Thirty-two eyes of 24 patients with Age-Related Macular Degeneration (AMD) and drusen maculopathy were included. In the central 1 and 3 mm ETDRS circle drusen volumes were calculated and compared. Drusen segmentation was performed using automated manufacturer algorithms of the two OCT devices. Then, the automated segmentation was manually corrected and compared and finally analyzed using customized so

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White, Robert J., Daniel J. Watson, Dara D. Koozekanani, and Sandra R. Montezuma. "Association of Optic Nerve Head Drusen with Best Vitelliform Macular Dystrophy: A Case Series." Case Reports in Ophthalmology 9, no. 1 (2018): 82–92. http://dx.doi.org/10.1159/000485963.

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Purpose: To report the association of optic nerve head (ONH) drusen with Best vitelliform macular dystrophy (BVMD). Methods: Chart review. Patients: Five patients from 3 families. Results: Multimodal imaging and ophthalmic examination demonstrated findings consistent with ONH drusen, in association with BVMD, in 5 patients. Conclusion: We report the association of BVMD with ONH drusen in 5 patients. This combination has previously been reported only once. We recommend that patients with a diagnosis of BVMD undergo autofluorescence and ultrasound imaging of the optic nerve to help facilitate th

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Кабанова, Evgeniya Kabanova, Иойлева, Elena Ioyleva, Котова, and Elena Kotova. "POSSIBILITIES OF MODERN IMAGING TECHNIQUES IN DIAGNOSTICS OF OPTIC NERVE DRUSEN (LITERATURE REVIEW)." Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук 1, no. 6 (2016): 206–9. http://dx.doi.org/10.12737/23842.

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With the introduction and development of new diagnostic techniques, the relevance of drusen of the optic nerve di-agnostics is increasing. Existing imaging techniques alone or in their various combinations cannot allow to confirm optic nerve drusen in all clinical cases. The diagnosis of optic nerve drusen causes some difficulties because of absence of clear diagnostic standards and classification. Since the advent of new ophthalmological methods of structural and topographic visual analysis evaluation, such as spectral-domain optical coherence tomography, Heidelberg retina tomography, videooc

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Rodríguez, Anabel, Marc Biarnés, Rosa M. Coco-Martin, Anna Sala-Puigdollers, and Jordi Monés. "Early Detection of Incipient Retinal Pigment Epithelium Atrophy Overlying Drusen with Fundus Autofluorescence vs. Spectral Domain Optical Coherence Tomography." Journal of Ophthalmology 2020 (September 16, 2020): 1–8. http://dx.doi.org/10.1155/2020/9457457.

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Purpose. This study aims to find out which tool, fundus autofluorescence (FAF) or spectral domain optical coherence tomography (SD-OCT), is more sensitive in detecting retinal pigment epithelium (RPE) demise overlying drusen and can, therefore, help predict geographic atrophy (GA) appearance in Age-Related Macular Degeneration (AMD). Methods. A single-site, retrospective, observational, longitudinal study was conducted. Patients with intermediate AMD (iAMD) (large (>125 μm) or intermediate (63–125 μm) drusen with hyper/hypopigmentation) with a minimum follow-up of 18 months were included. D

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López-Cuenca, Inés, Elena Salobrar-García, Inés Gil-Salgado, et al. "Characterization of Retinal Drusen in Subjects at High Genetic Risk of Developing Sporadic Alzheimer’s Disease: An Exploratory Analysis." Journal of Personalized Medicine 12, no. 5 (2022): 847. http://dx.doi.org/10.3390/jpm12050847.

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Having a family history (FH+) of Alzheimer’s disease (AD) and being a carrier of at least one ɛ4 allele of the ApoE gene are two of the main risk factors for the development of AD. AD and age-related macular degeneration (AMD) share one of the main risk factors, such as age, and characteristics including the presence of deposits (Aβ plaques in AD and drusen in AMD); however, the role of apolipoprotein E isoforms in both pathologies is controversial. We analyzed and characterized retinal drusen by optical coherence tomography (OCT) in subjects, classifying them by their AD FH (FH- or FH+) and t

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Parameswarappa, Deepika Chennapura, and Padmaja Kumari Rani. "Utility of pattern recognition and multimodal imaging in the diagnosis and management of doyne honeycomb retinal dystrophy complicated with type one choroidal neovascular membrane." BMJ Case Reports 14, no. 2 (2021): e237635. http://dx.doi.org/10.1136/bcr-2020-237635.

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A 44-year-old woman presented with decreased vision in both eyes. The retina in both eyes had drusen distributed along vascular arcades, central macula and in peripapillary region. Macula had pigmented scarring and exudation. Fundus autofluorescence showed drusen. Optical coherence tomography showed drusen, subretinal and intraretinal fluid. Fundus fluorescein and indocyanine green angiography showed drusen, retinal pigment epithelial atrophy and vascular network. Younger age at presentation, bilateral symmetry, typical distribution of drusen along the arcades in a radiating pattern, peripapil

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Sundari, N. Parvatha, E. Rajeswari, and V. Preethi. "A rare case report of Doyne’s honeycomb retinal dystrophy." Indian Journal of Ophthalmology - Case Reports 4, no. 1 (2024): 202–5. http://dx.doi.org/10.4103/ijo.ijo_1504_23.

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Doyne’s honeycomb dystrophy is a rare hereditary retinal dystrophy where drusens form in the macula and around the optic nerve head, resulting in choroidal neovascularization later. We report the case of a 63-year-old male with metamorphopsia in the right eye (RE) since 6 months. On examination, his visual acuity was 6/6 in both eyes. The anterior segment was normal. Fundus examination showed multiple drusen deposits in the macula and optic nerve head and hyperpigmentation in the macula. OCT showed hyperreflective bumpy retinal pigment epithelial in Bruch’s membrane. Fundus autofluorescence of

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Nittala, Muneeswar G., Federico Corvi, Jyotsna Maram, et al. "Risk Factors for Progression of Age-Related Macular Degeneration: Population-Based Amish Eye Study." Journal of Clinical Medicine 11, no. 17 (2022): 5110. http://dx.doi.org/10.3390/jcm11175110.

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Objective: To evaluate the optical coherence tomography (OCT)-based risk factors for progression to late age-related macular degeneration (AMD) in a population-based study of elderly Amish. Methods: A total of 1332 eyes of 666 consecutive subjects who completed a 2-year follow-up visit were included in this multicenter, prospective, longitudinal, observational study. Imaging features were correlated with 2-year incidence of late AMD development. Odds ratios for imaging features were estimated from logistic regression. Baseline OCT images were reviewed for the presence of drusen volume ≥0.03 mm

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Sato, Atsuko, Nami Senda, Emi Fukui, and Kouichi Ohta. "Retinal Angiomatous Proliferation in an Eye with Cuticular Drusen." Case Reports in Ophthalmology 6, no. 1 (2015): 127–31. http://dx.doi.org/10.1159/000381616.

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Purpose: To report the presence of retinal angiomatous proliferation (RAP) in an eye with cuticular drusen detected by fluorescein and indocyanine green angiography by confocal scanning laser ophthalmoscopy and by spectral-domain optical coherence tomography (SD-OCT). Methods: Case report of a 65-year-old Japanese woman with cuticular drusen. Results: At her first ophthalmic examination, her visual acuity was 20/20 in both eyes. An ophthalmoscopy showed many small subretinal pigment epithelial deposits in both eyes. These deposits had a ‘saw-tooth pattern' in the SD-OCT images. During the foll

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Giuffrè, G. "Optic Disc Drusen in Tilted Disc." European Journal of Ophthalmology 15, no. 5 (2005): 647–51. http://dx.doi.org/10.1177/112067210501500518.

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Purpose To investigate if a congenital anomaly of the head of the optic nerve like such as tilted disc can be a risk factor for the development of optic disc drusen. Methods The study was performed retrospectively on the files of 47 patients with optic disc drusen. The diagnosis was confirmed by fluorescein angiography and B-scan ultrasonography. The authors examined the fundus photographs and the fluorescein angiographies of these patients looking for the presence of tilted discs. Results Two of the 47 patients with optic nerve drusen had tilted discs as well, about twice the expected rate. B

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Kim, Sukjin, Jeongjae Oh, and Kiseok Kim. "Morphologic Changes in Patient with Drusen and Drusenoid Pigment Epithelial Detachment after Intravitreal Ranibizumab for Choroidal Neovascular Membrane : A Case Report." Open Ophthalmology Journal 10, no. 1 (2016): 1–4. http://dx.doi.org/10.2174/1874364101610010001.

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The authors present a case of morphologic changes of drusen and drusenoid pigment epithelial detachment (DPED) after treating choroidal neovascularization (CNV) using ranibizumab in age-related macular degeneration (AMD). A 71-year-old woman has noticed mild visual acuity deterioration in the right eye for several months. She was presented with some drusen and DPED associated with CNV. This patient was given intravitreal injection of 0.5 mg of ranibizumab five times at monthly intervals for treating CNV. DPED in the temporal and drusen in the superior to macula were diminished, which continued

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L., Jeganson Durai, and Vijayakumar J. "Quantum-Assisted Retinal Drusen Detection Algorithm using Entropy-Based Image Processing Techniques." International Journal of Engineering and Advanced Technology (IJEAT) 9, no. 3 (2020): 2251–56. https://doi.org/10.35940/ijeat.C5781.029320.

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Drusen identification is the fundamental operation in the automated diagnosis of eye diseases. Manual and automatic detection of the drusen in the retinal fundus images has been developed recently in the classical manner only. This work provides the quantum-based retinal drusen detection method using entropy-based image processing techniques. This algorithm is the composite system of two channels, classical and quantum channels for the preprocessing and drusen detection respectively. This research work has been evaluated with the databases of DRIVE, STARE, MESSIDOR, E-Optha-Ex and ONH-Hunter.

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Landa, G., A. Springer, A. Bukelman, and A. Pollack. "The Diagnostic Contribution of Indocyanine Green to Fluorescein Angiography in Fellow Drusen Eyes of Patients with Wet Age-Related Macular Degeneration." European Journal of Ophthalmology 17, no. 4 (2007): 615–19. http://dx.doi.org/10.1177/112067210701700421.

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Purpose To assess the contribution of indocyanine green angiography (ICGA) to fluorescein angiography (FA) in evaluating fellow drusen eyes of patients with wet age-related macular degeneration (AMD) in the other eye. Methods The records of paired FA and ICGA of patients with dry AMD in one eye and wet AMD in the other eye were retrospectively reviewed. Based on color fundus photographs, drusen were graded to low, moderate, or high grade of severity on FA. The FA and ICGA findings were compared. Results Fifty-two pairs of eyes were included. Fluorescein angiography showed drusen of low severit

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Ioyleva, E. E., and S. I. Belianina. "Treatment of the subretinal neovascularization associated with optic nerve head drusen." Russian ophthalmology of children, no. 3 (November 7, 2022): 51–57. http://dx.doi.org/10.25276/2307-6658-2022-3-51-57.

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Purpose. To describe a rare clinical case of bilateral choroidal neovascularization (CNV) associated with optic nerve head (ONH) drusen and to report a positive functional and clinical outcome of intravitreal injections of vascular endothelial growth factor inhibitors (anti-VEGF) in this patient. Material and methods. A 39-year-old man with ONH drusen complained of decreased visual acuity and distortion of objects. During the examination, the bilateral CNV was detected in peripapillary area. The patient received two consecutive intravitreal injections of anti-VEGF in the right eye and one inje

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Morgan, William H. "Macular drusen quantitation." Ophthalmology 107, no. 6 (2000): 1019. http://dx.doi.org/10.1016/s0161-6420(99)00171-2.

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Auw-Haedrich, Claudia, Flemming Staubach, and Heinrich Witschel. "Optic Disk Drusen." Survey of Ophthalmology 47, no. 6 (2002): 515–32. http://dx.doi.org/10.1016/s0039-6257(02)00357-0.

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Abeysiri, Poorna, Sobha Sivaprasad, and David Trew. "Optic disc drusen." Lancet 362, no. 9382 (2003): 468. http://dx.doi.org/10.1016/s0140-6736(03)14074-3.

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Barondes, M., D. Pauleikhoff, I. C. Chisholm, D. Minassian, and A. C. Bird. "Bilaterality of drusen." British Journal of Ophthalmology 74, no. 3 (1990): 180–82. http://dx.doi.org/10.1136/bjo.74.3.180.

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D’souza, Yvonne B., Carolyn J. P. Jones, Colin D. Short, and Richard E. Bonshek. "Basal laminar drusen and soft drusen have similar glycan composition." Canadian Journal of Ophthalmology 45, no. 3 (2010): 297–99. http://dx.doi.org/10.3129/i09-232.

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Trenkic-Bozinovic, Marija, Predrag Jovanovic, Gordana Zlatanovic, Dragan Veselinovic, Aleksandra Aracki-Trenkic, and Milan Trenkic. "Retinal hemorrhages as one of complications of optic disc drusen during pregnancy." Medical review 67, no. 5-6 (2014): 185–89. http://dx.doi.org/10.2298/mpns1406185t.

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Introduction. Drusen of the optic nerve head are relatively benign and asymptomatic. They represent retinal hyaline corpuscles resulting from impaired axoplasmic transport of the retinal ganglion cells of optic nerve in front of the lamina cribrosa. They are usually detected accidentally, during a routine ophthalmologic examination. Most patients with optic disc drusen are not aware of the deterioration of their eyesight because of the slow progression of visual field defects. Damage in visual acuity due to optic disc drusen is rare. Case Report. A 27-year-old female patient in the sixth month

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Notomi, Shoji, Satomi Shiose, Keijiro Ishikawa, et al. "Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients." PLOS ONE 16, no. 7 (2021): e0255213. http://dx.doi.org/10.1371/journal.pone.0255213.

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Drusen are known to be the important hallmark to predict the development of age-related macular degeneration (AMD). The prevalence of drusen is lower in Asians compared with Caucasians so that the role of signs constituting early AMD is not well established in Asian populations as in Western countries. In this study, we retrospectively investigated clinical characteristics and 5-year incidence of neovascular AMD (nAMD) in the fellow eye of unilateral nAMD patients. Of 296 consecutive unilateral nAMD patients who had been followed up more than 5 years, 170 typical AMD, 119 polypoidal choroidal

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Ayhan, Ziya, Aylin Yaman, Meltem Söylev Bajin, and A. Osman Saatci. "Unilateral Acute Anterior Ischemic Optic Neuropathy in a Patient with an Already Established Diagnosis of Bilateral Optic Disc Drusen." Case Reports in Ophthalmological Medicine 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/730606.

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Optic disc drusen (ODD) are calcific deposits that form in the optic nerve head secondary to abnormalities in axonal metabolism and degeneration. Anterior ischemic optic neuropathy, central retinal artery, and vein occlusion are among the rare vascular complications of disc drusen. We reported the clinical course of a 51-year-old patient with a unilateral acute nonarteritic anterior ischemic optic neuropathy (NAION) who received the diagnosis of bilateral optic disc drusen five years earlier and thereby reiterated the association of ODD and acute NAION.

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Савина, Yuliya Savina, Юрьева, et al. "INFLUENCE OF OPTIC NERVE DRUSEN ON VISUAL FUNCTIONS IN CHILDREN AND ADOLESCENTS WITH ESSENTIAL ARTERIAL HYPERTENSION." Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук 1, no. 6 (2016): 148–52. http://dx.doi.org/10.12737/23797.

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The article presents data examination of children and male adolescents, aged 8 to 17years without eye pathologies, with primary hypertension diagnosis – established at the clinic of Scientific Centre for Family Health and Human Re-production Problems. Examination results were: 42patients (84eyes) had primary hypertension with optic disc drusen, 8patients (16eyes) had primary hypertension without optic disc drusen.Characteristics of basic functional changes of patients ophthalmic status with and without optic disc drusen on the basis of data of visometry refractometry, keratometry, computer per

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Bellis, Raymond Matthew, Yang Fei, Brandon Le, et al. "Correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age-related macular degeneration." BMJ Open Ophthalmology 9, no. 1 (2024): e001622. http://dx.doi.org/10.1136/bmjophth-2023-001622.

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PurposeSubretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are associated with systemic vascular diseases that compromise ocular perfusion. We demonstrate that SDDs are associated with decreased ellipsoid zone (EZ) thickness, further evidence of hypoxic damage.MethodsPost hoc analysis of a cross-sectional study. 165 AMD subjects (aged 51–100; 61% women). Spectral-domain optical coherence tomography was obtained in both eyes. Masked readers assigned subjects to three groups: drusen only, SDD+drusen (SDD+D) and SDD only. EZ thickness was measured subfoveally and 2000 µ

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