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Dissertations / Theses on the topic 'Dry formulation'

Author: Grafiati

Published: 4 June 2025

Last updated: 15 July 2025

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1

Husman, Stephen H., Randy Wegener, and Frank Meizler. "Pix - Dry Flowable vs. Liquid Formulation Performance Evaluation." College of Agriculture, University of Arizona (Tucson, AZ), 1996. http://hdl.handle.net/10150/210771.

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Cotton crop response was evaluated using the growth regulator FIX in a conventional liquid formulation compared to an equivalent rate of a newly developed dry flowable (DF) formulation. The DF formulation will be available in 1996 in water soluble packets with each 57 gram packet the equivalent of one pint liquid PIX. Both formulations regulated plant height and height:node ratios equally.

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2

Vilkner, Torsten. "Miniaturised devices for dry powder handling in drug formulation." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419490.

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3

Schueller, Laurent. "Effects of particle surface modifications on dry powder formulation performances." Thesis, University College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425683.

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4

Ong, Michael Lau Hui. "The aerosol performance and physico-chemical properties of co-milled dry powder formulations for high dose delivery." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16277.

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The overall aim of the thesis was to investigate the aerosol performance and physico-chemical properties of dry powder formulations produced by co-milling an Active Pharmaceutical Ingredient (API- Beclomethasone Dipropionate - BDP) with an additive (Magnesium Stearate - MGST), using the jet mill apparatus, for high dose delivery. Co-milled formulations were produced at the set concentration of 1% w/w BDP, varying concentrations of MGST (0%-7.5% w/w), adding lactose as the final bulking agent. In general, 5% w/w MGST was found to be the optimal concentration for aerosol performance in terms of

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5

Afrose, Afrina. "Crystallization engineering techniques for developing a novel dry powder inhaler formulation for ibuprofen." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/107550/1/Afrina_Afrose_Thesis.pdf.

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The technique of producing inhalable particles (<5μm) for dry powder inhaler (DPI) formulations mostly involves crystallization followed by high energy input size reduction systems (e.g., milling and homogenization), which produces particles with very high surface energy and poor flow property that restricts the efficient dispersion of drug from the formulations. This investigation has used an anti-solvent precipitation crystallization (APC) method of producing inhalable ibuprofen (IBP) crystals for pulmonary delivery from a DPI formulation.

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6

Huang, Wenhua. "Investigation of semipermeable coated tablet and liposomal dry powder inhaler formulation of salbutamol sulfate." HKBU Institutional Repository, 2010. http://repository.hkbu.edu.hk/etd_ra/1159.

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7

Sprunk, Angela [Verfasser], Peter [Akademischer Betreuer] Kleinebudde, and Jörg [Akademischer Betreuer] Breitkreutz. "Dry Foams in pharmaceutical formulation / Angela Sprunk. Gutachter: Peter Kleinebudde ; Jörg Breitkreutz. Betreuer: Peter Kleinebudde." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2014. http://d-nb.info/1047440512/34.

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8

Abdul, Le Brun Laure. "Mise au point d’une méthodologie pour la formulation des bétons secs à démoulage immédiat." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTS035/document.

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De nos jours, le bloc est le produit le plus vendu en préfabrication, avec un chiffre d’affaires de 418 millions d’euros en 2015 (chiffres issus de la Fédération de l’Industrie du Béton). Toutefois, ce résultat atteste d’une baisse de production constatée depuis 2012.Dans ce contexte économique difficile, les industriels cherchent à optimiser la formulation de leurs produits. Les particularités de ceux-ci (consistance sèche et teneur en air moyenne comprise entre 7 et 15 %) rendent impossible l’utilisation des outils existants.L’objectif de la thèse est alors de mettre au point une méthode de

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9

Al-Saedi, Zahraa Hasan Falhi. "Formulation and In vitro Evaluation of Cyclosporine A Inserts Prepared Using HPMC for Treating Dry Eye Disease." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1456095904.

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10

Muhsin, Mohammad Didare Alam. "Preparation and in vitro evaluation of a polymer based controlled release dry powder inhaler formulation for pulmonary delivery." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/71806/1/Mohammad%20Didare%20Alam_Muhsin_Thesis.pdf.

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This thesis described the synthesis of an L-leucine conjugate of the biodegradable polymer, chitosan and its potential application for the development of controlled release nanoparticulate dry powder inhaler (DPI) formulations. The study demonstrated that the physicochemical properties of conjugated chitosan nanoparticles had favourable effects on the dispersibility and controlled release profile of a model drug. The toxicity profile of the nanoparticulate formulation revealed promising outcome for its use in pulmonary delivery. The chitosan conjugate produced in this project would be useful f

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11

Tee, Seah Kee. "The influence of some formulation factors on drug delivery by dry powder aerosols : an in vitro/in vivo evaluation." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367513.

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12

Boc, Susan. "Aerosolized Surfactants: Formulation Development and Evaluation of Aerosol Drug Delivery to the Lungs of Infants." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5577.

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The overall aim of this research project was to develop surfactant dry powder formulations and devices for efficient delivery of aerosol formulations to infants using the excipient enhanced growth (EEG) approach. Use of novel formulations and inline delivery devices would allow for more efficient treatment of infants suffering from neonatal respiratory distress syndrome and bronchiolitis. A dry powder aerosol formulation has been developed using the commercial product, Survanta ® (beractant) and EEG technology to produce micrometer-sized hygroscopic particles. Spray drying and formulation para

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13

Caumon, Alexandre. "Formulation de molécules antivirales basées sur le Na-Succinate en poudres sèches pour l'administration pulmonaire." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASQ016.

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Les infections respiratoires virales, comme la grippe ou les coronavirus, constituent aujourd'hui un enjeu majeur de santé publique à l'échelle mondiale. En plus d'être hautement contagieuses, ces infections peuvent entraîner des conséquences à long terme, telles que des lésions respiratoires, des pneumonies ou des œdèmes pulmonaires. Pour des centaines de milliers de patients chaque année, ces complications se révèlent mortelles. Les antiviraux actuellement disponibles (Oseltamivir, Peramivir, etc.) sont le plus souvent administrés par voie orale ou intraveineuse et ne permettent pas un doubl

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14

Wang, Meng Jen. "Development of a Novel Detector Response Formulation and Algorithm in RAPID and its Benchmarking." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/97247.

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Solving radiation shielding problems, i.e. deep penetration problems, is a challenging task from both computation time and resource aspects in field of nuclear engineering. This is mainly because of the complexity of the governing equation for neutral particle transport - Linear Boltzmann Equation (LBE). The LBE includes seven independent variables with presence of integral and differential operators. Moreover, the low successive rate of radiation shielding problem is also challenging for solving such problems. In this dissertation, the Detector Response Function (DRF) methodology is proposed

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15

Thorpe, Peter Stuart. "An investigation into the dietary requirements of Oreochromis Mossambicus fry and the formulation and preparation of a dry food for use in aquaculture." Thesis, Rhodes University, 1989. http://hdl.handle.net/10962/d1001960.

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The need for developing a dry feed which satisfied the nutrient requirements of Oreochromis mossambicus fry was identified. The spawning and grading techniques which resulted in a higher fecundity and ensured uniformity within and between samples of fry are discussed. Preparation techniques were developed which met the physical requirements of fry feeds. An analysis of the flesh and yolk sac fry for amino acid composition was undertaken. The initial test diet was based on these results, as well as on the natural feeding ecology of the species. Feeding trials were undertaken and growth response

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16

Joseph, Cécile. "Emulsions de Pickering stabilisées par des poudres végétales : propriétés et rôle des paramètres de composition et de formulation." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0313/document.

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L’objectif de cette étude est de valoriser des coproduits végétaux tout en proposant une alternative biosourcée, économique et performante aux tensioactifs classiques. Des émulsions de type huile-dans-eau sont fabriquées à partir de poudres végétales finement broyées comme seul matériel tensioactif. Les systèmes dispersés qui en résultent, stabilisés par des particules solides, sont des émulsions dites de Pickering. La première partie de ce manuscrit décrit l’influence du procédé d’émulsification (rotorstator en régime turbulent, ultrasons et homogénéisation haute pression) et des paramètres d

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17

Agrawal, Swati. "Investigation and Optimization of a Solvent / Anti-Solvent Crystallization Process for the Production of Inhalation Particles." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2244.

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Dry powder inhalers (DPIs) are commonly used to deliver drugs to the lungs. The drug particles used in these DPIs should possess a number of key properties. These include an aerodynamic particle size < 5μm and particle crystallinity for long term formulation stability. The conventionally used micronization technique to produce inhalation particles offers limited opportunities to control and optimize the particle characteristics. It is also known to induce crystalline disorder in the particles leading to formulation instability. Hence, this research project investigates and optimizes a solven

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18

Azimi, Mandana. "EVALUATION OF THE REGIONAL DRUG DEPOSITION OF NASAL DELIVERY DEVICES USING IN VITRO REALISTIC NASAL MODELS." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4780.

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The overall objectives of this research project were i) to develop and evaluate methods of characterizing nasal spray products using realistic nasal airway models as more clinically relevant in vitro tools and ii) to develop and evaluate a novel high-efficiency antibiotic nanoparticle dry powder formulation and delivery device. Two physically realistic nasal airway models were used to assess the effects of patient-use experimental conditions, nasal airway geometry and formulation / device properties on the delivery efficiency of nasal spray products. There was a large variability in drug deliv

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19

Depreter, Flore. "Development of dry powder formulations of proteins for inhalation." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209719.

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A number of therapeutic proteins are used for long in clinical practice. These include for example insulin, calcitonine, growth hormone, and parathyroid hormone for the treatment of various systemic disorders, as well as protein antigens in vaccine formulations. Due to the recent developments in biochemical engineering and in the comprehension of the physiopathology of many diseases, peptides and proteins are expected to become a drug class of increasing importance. Recently, novel biological drugs have for example been developed such as monoclonal antibodies, antibody fragments, soluble recep

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20

Merlos, Romain. "Development of Triazole-based Dry Powder Formulations for Inhalation." Doctoral thesis, Universite Libre de Bruxelles, 2019. https://dipot.ulb.ac.be/dspace/bitstream/2013/289299/5/these.pdf.

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Among the different pulmonary fungal infections, aspergillosis, and in particular invasive pulmonary aspergillosis (IPA), are becoming the most worrying diseases in immunocompromised patients. This is due to their high incidence and mortality. Indeed, invasive aspergillosis manifests as invasive pulmonary disease accounting for 50/60% of all cases, with a mortality of 50-90% in severely immunocompromised patients. Triazoles act by inhibiting 14-α demethylase, a fungal cytochrome P450 enzyme implicated in the synthesis of ergosterol, an essential constituent of fungal cell walls. Moreover, they

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21

Robertson, Debra Louise Norton. "Effect of carrier shape and texture on drug availability of aerosolised particles." Thesis, University of Bath, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389946.

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22

Wang, Hui. "Development of nicotine loaded chitosan nanoparticles for lung delivery." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/108006/1/Hui_Wang_Thesis.pdf.

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This research offers a specific strategy for the management of a global health problem associated with smoking addiction. Novel controlled release nicotine-loaded chitosan nanoparticles have been developed as a potential therapy. In vitro and in vivo evaluation of these nanoparticles indicate that they are suitable as dry powder inhaler formulations for pulmonary delivery. Results from a mouse model should translate to humans to provide a safe and effective approach to treat smoking dependence.

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23

El-Sabawi, Dina. "Novel surface engineering of carrier particles for dry powder inhalation formulations." Thesis, University of Bath, 2005. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418593.

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24

Sarup, Louise Santha. "Investigation of supercritical fluid technology to produce dry particulate formulations of antibody fragments." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406707.

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25

Begat, Philippe Michel. "Quantification and control of cohesive and adhesive forces in dry powder inhaler formulations." Thesis, University of Bath, 2004. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415769.

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26

Farkas, Dale. "Development of High Efficiency Dry Powder Inhalers for Use with Spray Dried Formulations." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5158.

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Dry powder inhalers (DPIs) are advantageous for delivering medication to the lungs for the treatment of respiratory diseases because of the stability of the powders, relative low cost, synchronization of inhalation and dose delivery, and many design options that can be used for optimization. However, currently marketed DPIs are very inefficient in delivering medications to the lungs. This study has developed multiple new high efficiency DPIs for use with spray dried excipient enhanced growth (EEG) powder formulations based on the following platforms: capsule-based for oral inhalation, high-

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27

Pilcer, Gabrielle. "New highly effective dry powder tobramycin formulations for inhalation in the treatment of cystic fibrosis." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210447.

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Local delivery of medication to the lung is highly desirable as the principal advantages include reduced systemic side effects and higher dose levels of the applicable medication at the site of drug action. This administration could be particularly useful for patients with specifically chronic pulmonary infections or pulmonary diseases, such as cystic fibrosis, asthma or lung cancer.<p>In order to deliver a high dose range of medication for highly-dosed drugs such as antibiotics, “carrier-free” DPI formulations of tobramycin were developed with the aim of minimizing the use of excipients. Brie

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28

Rosiere, Rémi. "Development of dry powder formulations for inhalation based on nanomedicine for targeted lung cancer therapy." Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/232374/3/TOC.pdf.

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Le cancer du poumon est l’un des cancers les plus fréquents dans le monde et reste le plus meurtrier actuellement en terme d’incidence absolue. Les traitements employés chez les patients atteints d’un cancer du poumon consistent en une combinaison de chirurgie, de radiothérapie et de chimiothérapie. Alors qu’il y a quelques années, les guidelines de traitement étaient principalement basées sur le stade clinique de la maladie, le développement de nouvelles thérapies a mené à une classification plus appropriée des cancers du poumon. Cette nouvelle classification se base, en plus du stade cliniqu

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29

Jaffari, Sara. "Engineering particle agglomeration in dry powder inhaler formulations to co-deliver drugs to the lungs." Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/engineering-particle-agglomeration-in-dry-powder-inhaler-formulations-to-co-deliver-drugs-to-the-lungs(de73d77c-8793-4bac-b261-69a224ba598e).html.

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Dry powder inhalers (DPIs) are well established as a means of delivering inhaled drugs to the lungs. Combination DPIs, containing two or more drugs in a single formulation, may improve patient compliance by simplifying medication regimens. The implications of co-formulation on the aerosolisation behaviour of the component drugs, however, are not fully understood. Using salmeterol xinafoate (SX) and fluticasone propionate (FP) as model drug powders, a systematic approach was undertaken to better understand the consequences of combination formulation on drug dispersion for inhaled delivery. A dr

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30

Cabral, Renato Manuel Pereira. "Development of chitosan-based microparticles for pulmonary drug delivery." Master's thesis, Faculdade de Ciências e Tecnologia, 2013. http://hdl.handle.net/10362/10505.

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Dissertação para obtenção do Grau de Mestre em Engenharia Química e Bioquímica<br>In this work, novel chitosan (CHT) based microparticles were prepared using supercritical assisted atomization (SAA) and evaluated as potential carriers for sustained pulmonary drug delivery. CHT is a polysaccharide comprising of glucosamine and N-acetylglucosamine units, it is biodegradable, biocompatible and non-toxic being an interesting choice to be used as a drug carrier for inhalation therapy and belongs to the group of swellable polymers. By utilizing SAA, spherical microparticles containing a sharp parti

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31

Al, Ayoub Yuosef. "Development of a Dry Powder Inhaler and Nebulised Nanoparticle-Based Formulations of Curcuminoids for the Potential Treatment of Lung Cancer. Development of Drug Delivery Formulations of Curcuminoids to the Lungs using Air Jet Milling and Sonocrystallisation Techniques for Dry Powder Inhaler Preparations; and Nanoemulsion and Microsuspension for Nebuliser Formulations." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/15324.

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32

Jones, Matthew D. "An investigation into the dispersion mechanisms of ternary dry powder inhaler formulations by the quantification of interparticulate forces." Thesis, University of Bath, 2006. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432383.

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33

Schoug, Åsa. "A dry phase of life : freeze-drying and storage stability of Lactobacillus coryniformis Si3 in sucrose-based formulations /." Uppsala : Swedish University of Agricultural Sciences, 2009. http://diss-epsilon.slu.se/archive/00002000/01/Schoug_a_20090507.pdf.

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34

Tuli, Rinku. "Studies on the surface properties of biodegradable polymer carriers in respiratory delivery of drug from Dry Powder Inhaler formulations." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/53295/1/Rinku_Tuli_thesis.pdf.

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Dry Powder Inhaler (DPI) technology has a significant impact in the treatment of various respiratory disorders. DPI formulations consist of a micronized drug (<5ìm) blended with an inert coarse carrier, for which lactose is widely used to date. DPIs are one of the inhalation devices which are used to target the delivery of drugs to the lungs. Drug delivery via DPI formulations is influenced by the physico-chemical characteristics of lactose particles such as size, shape, surface roughness and adhesional forces. Commercially available DPI formulations, which utilise lactose as the carrier, are

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35

Wauthoz, Nathalie. "Développement et évaluation de formulations pour inhalation à base d'anticancéreux dans le cadre du traitement des tumeurs pulmonaires." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209814.

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Les tumeurs pulmonaires, qu’elles soient primaires (principalement représentées par le cancer du poumon non-à-petites cellules) ou secondaires (métastases), causent la mort de plusieurs centaines de milliers de personnes par an à travers le monde. Malgré les modalités de traitements existantes, un plateau thérapeutique a été atteint avec un taux de survie à 5 ans de maximum 15%. Actuellement, il est connu que le cancer du poumon non-à-petites cellules ainsi que les métastases sont intrinsèquement résistants à l’apoptose.<p>Pour apporter des réponses aux principales problématiques rencontrées a

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36

Larrue, Chloé. "Formulations réactives d'élastomères thermoplastiques pour l'amélioration de leur déformation rémanente après compression." Electronic Thesis or Diss., Lyon, 2021. http://www.theses.fr/2021LYSE1324.

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L’objectif de ces travaux de thèse est de développer un nouveau matériau pour des applications d’étanchéité dans l’industrie automobile. Pour cela, ce dernier doit présenter à la fois de bonnes propriétés de recouvrance élastique en compression (test de DRC) et une bonne mise en œuvre, permettant le recyclage. Pour cela différentes voies de réticulation ont été étudiées. Nous avons commencé par étudier une réticulation ionique, et son association a une réticulation par voie radicalaire sur un EPDM-g-AM. Ce système a par la suite été appliqué à des mélanges plus complexes, de type formulation i

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Bueche, Blaine. "The Effect of PEG-Insulin and Insulin Hexamer Assembly on Stability in Solution and Dry Powders. Hexamer Assembly of PEGylated-Insulin and Insulin Studied by Multi-Angle Light Scattering to Rationally Choose the pH and Zinc Content for Analytical Methods and Formulations of Dry Powders." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/5688.

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The objective of this research is to further define the relationship between the charge state of insulin, and the self assembly properties of insulin and PEGylated insulin in solution. Polyethylene glycol (PEG) chains were covalently attached to insulin in order to evaluate their impact on insulin's systemic duration of action after pulmonary dosing. This thesis will focus on the assembly properties of the PEG-insulin and insulin, and also demonstrate how the charge state, which was modified by the covalent attachment of PEG, relates to different modes of behavior by anion and cation exchange

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Mohamed, Noha Nahedj Atia. "Pharmaceutical analysis and in-vitro aerodynamic characterisation of inhaled theophylline formulations containing drug particles prepared by supercritical fluid processing : chromatographic, spectroscopic, and thermal analysis of micron-sized theophylline particles prepared by supercritical fluid technology and in-vitro evaluation of their performance as inhaled dry powder formulations." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4297.

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The aim of this work is to study the in-vitro aerodynamic performance of a new inhaled theophylline formulation prepared by supercritical fluids technique. For the analysis of the output from the in-vitro tests (and further in-vivo tests) a new, fast, sensitive high performance liquid chromatographic (HPLC) method was developed and validated for the determination of theophylline and other related derivatives in aqueous and urine samples using new packing materials (monolithic columns). These columns achieve efficient separation under lower backpressure and shorter time comparing to other tradi

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Mohamed, Noha N. A. "Pharmaceutical analysis and in-vitro aerodynamic characterisation of inhaled theophylline formulations containing drug particles prepared by supercritical fluid processing. Chromatographic, spectroscopic, and thermal analysis of micron-sized theophylline particles prepared by supercritical fluid technology and in-vitro evaluation of their performance as inhaled dry powder formulations." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4297.

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The aim of this work is to study the in-vitro aerodynamic performance of a new inhaled theophylline formulation prepared by supercritical fluids technique. For the analysis of the output from the in-vitro tests (and further in-vivo tests) a new, fast, sensitive high performance liquid chromatographic (HPLC) method was developed and validated for the determination of theophylline and other related derivatives in aqueous and urine samples using new packing materials (monolithic columns). These columns achieve efficient separation under lower backpressure and shorter time comparing to other

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40

Polaha, Jodi, William T. III Dalton, and Blake M. Lancaster. "Parental Report of Medication Acceptance Among Youth: Implications for Every Day Practice." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etsu-works/6746.

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Lin, Tsung-Hsien, and 林宗賢. "The Development of Water Dispersible Granule Formulation of Six Pesticides with Spray-Dry Method." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/efnfrq.

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碩士<br>朝陽科技大學<br>應用化學系碩士班<br>92<br>For several years, water dispersible granule are becoming an increasingly important pesticide systems. In this study, six active ingredients of pesticide such as ametryne, benomyl, carbaryl, chlorothalonil, methomyl and pencycuron were used in the formulation research. Currently these six pesticides are used in large quantity as wettable powder in Taiwan and should be converted into safer formulation-water dispersible granule（WG）. In this study, spray-dryer is the major mechine, to make water dispersible granule. Modifications were made in mechine paramete

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(6955364), Nivedita J. Shetty. "Effect of Storage Humidity on Physical Stability and Aerosol Performance of Spray-Dried Dry Powder Inhaler Formulations." Thesis, 2019.

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<p>Dry Powder inhalers (DPIs) have been one of the most promising developments in pulmonary drug delivery systems. In general, DPIs are more effective than systemic administrations and convenient to use. However, delivering high-dose antibiotics through a DPI is still a challenge because high powder load may need a very large inhaler or increase the incidence of local adverse effects. Spray drying has been increasingly applied to produce DPI formulations for high-dose antibiotics; nevertheless, many spray-dried particles are amorphous and physically unstable during storage, particularly under

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Moura, Cláudia Consuelo Vieira Reis Leite. "Improved Particle Engineering and DPI Formulation for Optimal Pulmonary Delivery." Doctoral thesis, 2016. http://hdl.handle.net/10362/20779.

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The pharmaceutical interest to deliver drugs to the lungs has been increasing to treat local diseases like asthma or for systemic treatment, as insulin for diabetics. Pulmonary drug delivery enables a rapid drug action and bioavailability while avoiding the first pass metabolism and reducing the drug load required, minimizing adverse side effects and creating a more efficient therapy. The main goal of this work was to investigate, benchmark and optimize the different formulations and process parameters of the particle engineering technologies in order to optimize pulmonary drug delivery

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Aloum, Fatima, Ayoub Yuosef Al, Mohammad A. Mohammad, Muthana Obeed, Krzysztof J. Paluch, and Khaled H. Assi. "Ex vivo and in vitro evaluation of the influence of the inhaler device and formulation on lung deposition of budesonide." 2020. http://hdl.handle.net/10454/17991.

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Yes<br>Two different types of dry powder inhalers (Easyhaler® and RS01®) were used in this work to evaluate the ex vivo and in vitro performance of a budesonide inhaled formulation with recrystallised mannitol, commercial DPI-grade mannitol, or lactose. The aerodynamic performance of the budesonide formulation with recrystallised mannitol was superior when RS01® was used (FPF = 45.8%) compared to Easyhaler® (FPF = 14%). However, the aerodynamic profile was very poor in both devices when commercial mannitol was used. Interestingly, the aerosol performance of the marketed budesonide formulation

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Carvalho, Simone Raffa. "Improved inhalation therapies of brittle powders." Thesis, 2013. http://hdl.handle.net/2152/28736.

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Advancements in pulmonary drug delivery technologies have improved the use of dry powder inhalation therapy to treat respiratory and systemic diseases. Despite remarkable improvements in the development of dry powder inhaler devices (DPIs) and formulations in the last few years, an optimized DPI system has yet to be developed. In this work, we hypothesize that Thin Film Freezing (TFF) is a suitable technology to improve inhalation therapies to treat lung and systemic malignancies due to its ability to produce brittle powder with optimal aerodynamic properties. Also, we developed a performance

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Branco, Bernardo Ferreira da Silva Mecheiro. "Excipientes para formulação DPI." Master's thesis, 2019. http://hdl.handle.net/10451/43372.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2019<br>O ser humano utiliza diversas vias para administração de fármacos para tratamentos de diversas patologias. Umas dessas vias é a via pulmonar, a qual o Homem já utiliza há milhares de anos, através da inalação de substâncias que vão exercer ação farmacológica no organismo. Um dos tipos de dispositivos que foram desenvolvidos são os Dry Powder Inhaler (DPI’s), ou seja inaladores de pó seco. Mas o fármaco utilizado neste tipo de dispositivos necessita de excipientes que permitirão

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Allinsin, Anthony James. "An analysis of the factors influencing the relationship between soil properties and optimum moisture content and the formulation of an abbreviated test method of determinig maximum dry density." Thesis, 1997. http://hdl.handle.net/10321/2892.

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Dissertation submitted in compliance with the requirements for the Masters Degree in Technology: Civil Engineering, Technikon Natal, 1997.<br>The strength and durability of any soil structure is dependent on the quality of the compaction of the soil. This quality is measured by employing a standard compaction test, which provides a standard with which density may be compared, called the maximum dry density, and the moisture content of the soil at which this is achieved, called the optimum moisture content. As a matter of routine during quality control, the particle size distribution, plasticit

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Morais, Guilherme Mota Horta. "Dry powder formulations for antibiotic pulmonary delivery." Master's thesis, 2018. http://hdl.handle.net/10362/41209.

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In this work, dry powder formulations (DPFs) containing fusidic acid were produced for the purpose of studying the pulmonary delivery of this drug. As fusidic acid is poorly soluble in aqueous media, this drug was conjugated with two different hydrophilic polymers to increase the bioavailability of the drug. The two hydrophilic polymers used were methoxypolyethylene glycol amine, a commercial product, and poly(2-ethyl-2-oxazoline), that was synthesized by supercritical-assisted CO2 polymerization and then end-capped with ethylenediamine. The conjugation compounds were synthesized in one-pot r

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Almeida, Vanessa Clemente. "Dry powder formulations containing bioactive compounds from marine Actinobacteria." Master's thesis, 2015. http://hdl.handle.net/10362/50886.

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Lower respiratory infections were the leading cause of sickness and mortality in 2013.1 The treatment of such infections relies on antibiotic therapy. However, antibiotic resistance to human pathogens and the prevalence of new cancer types continues to increase, so it is imperative not only to discover new lead-like drugs agents, but also develop new drug delivery systems for pulmonary diseases.2,3 In order to achieve such goal, it was isolated and elucidated antibacterial compounds from a marine-sediment-derived Actinobacteria, collected along Madeira archipelago. These bioactive compounds we

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Silva, Mariana Fernandes da. "Advanced particle engineering and characterization of model biopharmaceuticals for dry powder inhaler formulations." Master's thesis, 2018. http://hdl.handle.net/10451/40064.

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Tese de mestrado, Engenharia Farmacêutica, Universidade de Lisboa, Faculdade de Farmácia, 2018<br>The Pharmaceutical industry is increasingly investing in biopharmaceuticals. Moreover, alternative delivery routes are being investigated over the conventional parenteral administration route, which presents several inconveniences for the patients including discomfort, pain and the impossibility of self-administration in the majority of cases. Thus, pulmonary and nasal delivery are emerging as alternative administration routes for the treatment of systemic diseases and administration of biopharmac

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