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Journal articles on the topic 'Dry formulation'
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Sajjad Qaisar, Masood-ur-Rehman Aarbi, Shahiq-uz-Zaman, Ammar Sadiq, and Talha Rafique. "Formulation development and characterization of famotidine dry suspension for oral use." Journal of Contemporary Pharmacy 6, no. 2 (2022): 49–56. http://dx.doi.org/10.56770/jcp2022622.
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Famotidine an H2 receptor blocker is generally used to treat ulcers of stomach and intestine. Famotidine is available in liquid suspension that is unstable during shelf life. Degradation of the drug as well as bad smell and color change is major problem in liquid suspension. This problem may be solved by formulating the drug as a dry suspension. We prepared four different formulations of famotidine as dry suspension. Geometric mixing methodology was followed to prepare the formulations. IR-spectroscopy showed no incompatibility between excipients used and API. Tests performed to evaluate formulations include assay, pH, viscosity, flow property, sedimentation volume and re-dispersibility. Among all the developed formulations, F3 was most ideal having excellent flow property, 100% drug assay, optimum viscosity and pH. Other formulations displayed some problems like viscosity of F1 was high that caused difficulty in flow while assay of F2 was 94% and F4 had bitter taste and low pH value. Hence F3 formulation was selected for further studies and kept for six months in stability chamber at accelerated conditions having temperature 40 °C ±2 and 75% ±5 R.H. samples were taken at 0, 1, 2, 3, 4 and 6 months to evaluate stability of the dry formulation. Moreover formulation (F3) was reconstituted with water and placed at accelerated conditions for 28 days to check its stability. Samples were taken at 0, 1, 2, 3, and 4 weeks. Results showed that no change occurred in both dry and reconstituted suspension during stability studies. It can be concluded on the basis of these findings that F3 formulation was stable and can be used in future.
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Chono, Sumio, Shiori Ishikawa, Akari Ikeda, and Kohei Togami. "Usability of theophylline extended-release dry syrups." Journal of Generic Medicines: The Business Journal for the Generic Medicines Sector 14, no. 4 (2018): 175–79. http://dx.doi.org/10.1177/1741134318802605.
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Objectives We examined the usability of theophylline extended-release dry syrups, including their powder fluidity and ingestibility using one branded and six generic formulations (formulations A, B, C, D, E, F, and G, respectively). Methods To evaluate the ease of handling by pharmacists, powder fluidity was evaluated by measuring the repose angle, whereas to determine ingestibility, the viewpoints of patients or caregivers were evaluated using a questionnaire survey. Results and discussion: The repose angles of formulations A, B, C, D, E, and F were approximately 30°–40°. These formulations had sufficient powder fluidity, indicating the ease of weighing for most pharmacists. However, the repose angle of formulation G was <30°. Formulation G had high fluidity, suggesting its high rolling property. Thus, powder handling for formulation G may be more difficult than that for other six formulations. The ingestibility, such as the ease of mixing the dry syrup with water and odor intensity, was different between the formulations. Conclusions The present study provides useful information for selecting branded or generic theophylline extended-release dry syrups.
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Aygüler, Cemre İrem, Özlem Akbal Dağıstan, and Ayca Yıldız Peköz. "An overview of dry powder inhaler production methods." Journal of Research in Pharmacy 29, no. 3 (2024): 1333–49. https://doi.org/10.12991/jrespharm.1712419.
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In comparison with alternative delivery strategies, pulmonary administration of drugs may provide several benefits, especially when utilizing dry powder formulations. The studies have frequently concentrated on dry powder inhalers (DPIs) due to certain pros with regard to stability, dose, and patient preference. Milling, freeze-drying, spray-drying, and electrospray are the production methods for DPIs. Conventional carrier-based DPIs and newgeneration carrier-free DPIs are two essential kinds of DPI formulations. In the marketplace today, carrier-based formulations generate the majority of DPIs. To improve the dispersibility of inhalable dry powders, formulation approaches typically involve the incorporation of micronized active pharmaceutical ingredients (APIs) with larger-sized particles, like lactose, as carriers. Nevertheless, in carrier-based formulations, the dose of drugs that could be given to patients is lower compared to carrier-free formulations. The lung deposition of the majority of carrier-based formulations is still not particularly high. Individuals who have a diagnosed allergy to lactose ought to avoid DPI products based on lactose carriers. Lactose can also interact with the functional groups of drugs or proteins since it is a reducing sugar. Furthermore, the quality and source of the lactose have been found to have a significant impact on a powder formulation's effectiveness. Carrier-free formulations seem like an advantageous choice in these situations. In this review, the formulation excipients of carrier-based and carrier-free DPIs were evaluated. Alternative delivery systems and production technologies for DPIs were also discussed.
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Tulbah, Alaa S., Hui Xin Ong, Lucy Morgan, Paolo Colombo, Paul M. Young, and Daniela Traini. "Dry powder formulation of simvastatin." Expert Opinion on Drug Delivery 12, no. 6 (2014): 857–68. http://dx.doi.org/10.1517/17425247.2015.963054.
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Kotkar, Vikas. "Formulation and Evaluation of Dry Powder Inhaler." International Journal for Research in Applied Science and Engineering Technology 10, no. 6 (2022): 4625–37. http://dx.doi.org/10.22214/ijraset.2022.44915.
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Abstract: This review focuses on the dry powder inhaler (DPI) formulation and development process. Most DPI formulations consist of micronized drug blended with larger carrier particles, which enhance flow, reduce aggregation, and aid in dispersion. A combination of intrinsic physicochemical properties, particle size, shape, surface area, and morphology affects the forces of interaction and aerodynamic properties, which in turn determine fluidization, dispersion, delivery to the lungs, and deposition in the peripheral airways. When a DPI is actuated, the formulation is fluidized and enters the patient’s airways. Under the influence of inspiratory airflow, the drug particles separate from the carrier particles and are carried deep into the lungs, while the larger carrier particles impact on the oropharyngeal surfaces and are cleared. If the cohesive forces acting on the powder are too strong, the shear of the airflow may not be sufficient to separate the drug from the carrier particles, which results in low deposition efficiency. This review thus demonstrates that the successful delivery of dry powder aerosols to the lung requires careful consideration of the powder production process, formulation and inhaler device. The developments and improvements towards high dose powder pulmonary drug delivery are summarized and discussed here. It also throws light on the invention and improvement of novel inhaler devices as well as the further development of formulation principles and new powder engineering methods.
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Rashid, Md Abdur, Amged Awad Elgied, Yahya Alhamhoom, et al. "Excipient Interactions in Glucagon Dry Powder Inhaler Formulation for Pulmonary Delivery." Pharmaceutics 11, no. 5 (2019): 207. http://dx.doi.org/10.3390/pharmaceutics11050207.
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Purpose: This study describes the development and characterization of glucagon dry powder inhaler (DPI) formulation for pulmonary delivery. Lactose monohydrate, as a carrier, and L-leucine and magnesium stearate (MgSt) were used as dispersibility enhancers for this formulation. Methods: Using Fourier-transform infrared (FTIR) spectroscopy, Differential Scanning Calorimetry (DSC), and Raman confocal microscopy, the interactions between glucagon and all excipients were characterized. The fine particle fractions (FPFs) of glucagon in different formulations were determined by a twin stage impinger (TSI) using a 2.5% glucagon mixture, and the glucagon concentration was measured by a validated LC-MS/MS method. Results: The FPF of the glucagon was 6.4%, which increased six-fold from the formulations with excipients. The highest FPF (36%) was observed for the formulation containing MgSt and large carrier lactose. The FTIR, Raman, and DSC data showed remarkable physical interactions of glucagon with leucine and a minor interaction with lactose; however, there were no interactions with MgSt alone or mixed with lactose. Conclusion: Due to the interaction between L-leucine and glucagon, leucine was not a suitable excipient for glucagon formulation. In contrast, the use of lactose and MgSt could be considered to prepare an efficient DPI formulation for the pulmonary delivery of glucagon.
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Rashid, Md Abdur, Saiqa Muneer, Tony Wang, et al. "Puerarin dry powder inhaler formulations for pulmonary delivery: Development and characterization." PLOS ONE 16, no. 4 (2021): e0249683. http://dx.doi.org/10.1371/journal.pone.0249683.
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This study aims at developing and characterizing the puerarin dry powder inhaler (DPI) formulations for pulmonary delivery. The inhalable particles size (<2 μm) was accomplished by micronization and its morphology was examined by scanning electron microscopy (SEM). The puerarin-excipient interaction in powder mixtures was analyzed by using Fourier transform infrared spectroscopy (FTIR), Raman confocal microscopy, X-Ray powder Diffraction (XRD), and differential scanning calorimetry (DSC) methods. Using a Twin stage impinger (TSI), the in-vitro aerosolization of the powder formulations was carried out at a flow rate of 60 L/min and the drug was quantified by employing a validated HPLC method. No significant interactions between the drug and the excipients were observed in the powder formulations. The fine particle fraction (FPF) of the drug alone was 4.2% which has increased five to six-fold for the formulations with aerosolization enhancers. Formulation containing lactose as large carriers produced 32.7% FPF, which further increased with the addition of dispersibility enhancers, leucine and magnesium stearate (40.8% and 41.2%, respectively). The Raman and FTIR techniques are very useful tool for understanding structural integrity and stability of the puerarin in the powder formulations. The puerarin was found to be compatible with the excipients used and the developed DPI formulation may be considered as an efficient formulation for pulmonary delivery for the management of various diseases at a very low dose.
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Oh, Euichaul, Uijung Kim, Beom-Jin Lee, and Cheol Moon. "Multivariate Statistical Optimization of Tablet Formulations Incorporating High Doses of a Dry Herbal Extract." Pharmaceutics 11, no. 2 (2019): 79. http://dx.doi.org/10.3390/pharmaceutics11020079.
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The development of oral tablet formulation for herbal medicines has been restricted by large drug loadings and the poor physicochemical and mechanical properties of dry herbal extracts (DHEs). Herein, statistical experimental designs were applied to herbal tablet formulation development and optimization using Wuzi Yanzong dry extract (WYE). The tablet disintegration time and hardness were identified as the critical quality attributes (CQAs) of the product. The tablet formulation was designed to achieve a high drug loading (50% or higher of WYE), shorter tablet disintegration time (less than 30 minutes), and suitable hardness (6.0 to 7.5 kp). A D-optimal mixture design was used to evaluate the effects of excipients on CQAs to minimize the risk compression failure and improve the tabletability in formulations containing WYE at 50% and 65% by weight. A partial least squares model was used to elucidate the multivariate relationships between a large number of formulation variables and product CQAs, and determine the maximum possible WYE loading. From overlaid plots of the effects of formulation variables on CQAs, it was found that a maximum WYE loading of 67% in tablet formulation satisfied the acceptance criteria of CQAs. In conclusion, this study shows that multivariate statistical tools are useful for developing tablet formulations containing high doses of herbal extracts and establishing control strategies that ensure product quality.
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Rajnikant, Unadkant Kishan, Dr Monika Maan, Ms Archana Pachore, Dr Revathi A. Gupta, Dr Gaurav Jain, and Mr Dheeraj Gour. "Formulation Development and Evaluation of Dry Powder Injection for Reconstitution." International Journal of Research Publication and Reviews 5, no. 12 (2024): 5440–45. https://doi.org/10.55248/gengpi.5.1224.0235.
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Cordts, Eike, and Hartwig Steckel. "Formulation considerations for dry powder inhalers." Therapeutic Delivery 5, no. 6 (2014): 675–89. http://dx.doi.org/10.4155/tde.14.35.
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Mane, P. N., M. P. Moharil, N. S. Satpute, et al. "Storage Stability and Performance of Aqueous and Dry Formulations of Helicoverpa armigera Nuclear Polyhedrosis Virus." Journal of Biological Control 30, no. 1 (2016): 34. http://dx.doi.org/10.18311/jbc/30/1/6457.
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Experiment on storage stability and performance of aqueous and dry formulation of <em>Helicoverpa armigera</em> nuclear polyhedrosis virus (HaNPV) was conducted during 2011-2013 in Bio control laboratory, Department of Entomology and Insect Biotechnology laboratory, Biotechnology Centre, Dr. Panjabrao Deshmukh Krishi Vidyapeeth, Akola with an objective to develop potent HaNPV formulation for improving shelf life and performance. Aqueous and dry form of HaNPV formulations with antimicrobials, UV protectant and phagostimulant were prepared and studied their shelf life and performance during storage. Synthesized and characterized the Silver nanoparticles. Prepared fresh Ha NPV required for preparing different formulation. The contaminants associated, storage stability and larvicidal activity of formulated HaNPV was studied. Data revealed that, HaNPV formulations having Silver nanoparticles @ 8 μl/ml of HaNPV and 80 μl/ml of HaNPV checked the bacterial contamination up to 13 months of the storage period, did not affect the viability of POBs and insecticidal properties of HaNPV formulation. Aqueous form of HaNPV + Streptomycin @ 0.18 g/lit of HaNPV + Tinopal 1% + Sucrose 1% , dry form of HaNPV + Streptomycin @ 0.18 g/lit of HaNPV + Tinopal 1% + Sucrose 1% and HaNPV + Streptomycin @ 0.18 g/lit of HaNPV + sucrose remain stabled up to 12 months. However, aqueous form of HaNPV alone reduces the insecticidal properties from the 9th month of storage period. While, dry form of HaNPV alone reduces the insecticidal properties from the 12th month of storage period. From the result, it was noticed that dry form of HaNPV formulation having antimicrobial found more stable than aqueous form.
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Geng, Xinglian, James Deng, and Shu Yin Zhang. "Paper mill sludge as a component of wood adhesive formulation." Holzforschung 61, no. 6 (2007): 688–92. http://dx.doi.org/10.1515/hf.2007.112.
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Abstract Three major types of paper mill sludge, primary sludge (PS), secondary sludge (SS) and de-inking paper sludge (DPS) were characterized and evaluated as adhesive fillers. Plywood panels were made of formulations with phenol formaldehyde (PF) and sludges. Panels with PF/PS and PF/SS formulations had higher dry and wet shear strengths than those made with PF/Cocob® formulation. All wood failure values were comparable. Dry and wet shear strengths of the panels with PF/DPS formulation were comparable to those of the PF/Cocob® panels (with Cocob® as a commercial filler), but the former displayed a much lower wood failure value. Owing to this fact and its high ash content, DPS was not evaluated further as a potential component of adhesive formulations. Compared with SS, PS resulted in higher dry and wet shear strengths and higher wood failure values. However, granular SS was easier to disperse into the resin component than fibrous PS, and the PF/SS formulation was more easily dispensed on aspen veneer sheets than the PF/PS formulation. SS alone displayed adhesive properties with 0.87 MPa of dry shear strength, but PS alone did not exhibit any bond strength. PS and SS were further evaluated for their general thermal behavior and major functional groups using differential scanning calorimetry and Fourier transform infrared spectrometry, respectively.
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Abiona, Olaitan, David Wyatt, Jasdip Koner, and Afzal Mohammed. "The Optimisation of Carrier Selection in Dry Powder Inhaler Formulation and the Role of Surface Energetics." Biomedicines 10, no. 11 (2022): 2707. http://dx.doi.org/10.3390/biomedicines10112707.
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This review examines the effects of particle properties on drug–carrier interactions in the preparation of a dry powder inhaler (DPI) formulation, including appropriate mixing technology. The interactive effects of carrier properties on DPI formulation performance make it difficult to establish a direct cause-and-effect relationship between any one carrier property and its effect on the performance of a DPI formulation. Alpha lactose monohydrate remains the most widely used carrier for DPI formulations. The physicochemical properties of α-lactose monohydrate particles, such as particle size, shape and solid form, are profoundly influenced by the method of production. Therefore, wide variations in these properties are inevitable. In this review, the role of surface energetics in the optimisation of dry powder inhaler formulations is considered in lactose carrier selection. Several useful lactose particle modification methods are discussed as well as the use of fine lactose and force control agents in formulation development. It is concluded that where these have been investigated, the empirical nature of the studies does not permit early formulation prediction of product performance, rather they only allow the evaluation of final formulation quality. The potential to leverage particle interaction dynamics through the use of an experimental design utilising quantifiable lactose particle properties and critical quality attributes, e.g., surface energetics, is explored, particularly with respect to when a Quality-by-Design approach has been used in optimisation.
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Lee, Wing-Hin, Ching-Yee Loo, Daniela Traini, and Paul M. Young. "Development and Evaluation of Paclitaxel and Curcumin Dry Powder for Inhalation Lung Cancer Treatment." Pharmaceutics 13, no. 1 (2020): 9. http://dx.doi.org/10.3390/pharmaceutics13010009.
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Despite the effort to develop efficient targeted drug delivery for lung cancer treatment, the outcome remains unsatisfactory with a survival rate of 15% after 5 years of diagnosis. Inhalation formulation is an ideal alternative that could ensure the direct deposition of chemotherapeutics to the lungs. However, the design of an inhalable formulation that could simultaneously achieve a high local chemotherapeutic dose to the solid tumor and exert low pulmonary toxicities is a challenge, as the presence of 10–30% of chemotherapeutics in the lung is sufficient to induce toxicity. Therefore, this study aimed to develop a simple dry powder inhalation (DPI) formulation containing a model chemotherapeutic agent (paclitaxel, PTX) and a natural antioxidant (curcumin, CUR) that acts to protect healthy lung cells from injury during direct lung delivery. The co-jet-milling of CUR and PTX resulted in formulations with suitable aerosol performance, as indicated in the high fine particle fractions (FPF) (>60%) and adequate mass median aerodynamic diameter (MMAD). The CUR/PTX combination showed a more potent cytotoxic effect against lung cancer cells. This is evident from the induction of apoptosis/necrotic cell death and G2/M cell cycle arrests in both A549 and Calu-3 cells. The increased intracellular ROS, mitochondrial depolarization and reduced ATP content in A549 and Calu-3 cells indicated that the actions of CUR and PTX were associated with mitochondrial oxidative stress. Interestingly, the presence of CUR is crucial to neutralize the cytotoxic effects of PTX against healthy cells (Beas-2B), and this is dose-dependent. This study presents a simple approach to formulating an effective DPI formulation with preferential cytotoxicity towards lung cancer.
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Magramane, Sabrina, Kristina Vlahović, Péter Gordon, et al. "Inhalation Dosage Forms: A Focus on Dry Powder Inhalers and Their Advancements." Pharmaceuticals 16, no. 12 (2023): 1658. http://dx.doi.org/10.3390/ph16121658.
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In this review, an extensive analysis of dry powder inhalers (DPIs) is offered, focusing on their characteristics, formulation, stability, and manufacturing. The advantages of pulmonary delivery were investigated, as well as the significance of the particle size in drug deposition. The preparation of DPI formulations was also comprehensively explored, including physico-chemical characterization of powders, powder processing techniques, and formulation considerations. In addition to manufacturing procedures, testing methods were also discussed, providing insights into the development and evaluation of DPI formulations. This review also explores the design basics and critical attributes specific to DPIs, highlighting the significance of their optimization to achieve an effective inhalation therapy. Additionally, the morphology and stability of 3 DPI capsules (Spiriva, Braltus, and Onbrez) were investigated, offering valuable insights into the properties of these formulations. Altogether, these findings contribute to a deeper understanding of DPIs and their development, performance, and optimization of inhalation dosage forms.
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Mehta, Piyush. "Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering." Journal of Drug Delivery 2018 (January 14, 2018): 1–19. http://dx.doi.org/10.1155/2018/5635010.
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Inhalation therapy has strong history of more than 4000 years and it is well recognized around the globe within every culture. In early days, inhalation therapy was designed for treatment of local disorders such as asthma and other pulmonary diseases. Almost all inhalation products composed a simple formulation of a carrier, usually α-lactose monohydrate orderly mixed with micronized therapeutic agent. Most of these formulations lacked satisfactory pulmonary deposition and dispersion. Thus, various alternative carrier’s molecules and powder processing techniques are increasingly investigated to achieve suitable aerodynamic performance. In view of this fact, more suitable and economic alternative carrier’s molecules with advanced formulation strategies are discussed in the present review. Furthermore, major advances, challenges, and the future perspective are discussed.
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Kumari, Sangeeta, Madhuri Dandamudi, Sweta Rani, et al. "Dexamethasone-Loaded Nanostructured Lipid Carriers for the Treatment of Dry Eye Disease." Pharmaceutics 13, no. 6 (2021): 905. http://dx.doi.org/10.3390/pharmaceutics13060905.
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Dry eye disease (DED) or keratoconjunctivitis sicca is a chronic multifactorial disorder of the ocular surface caused by tear film dysfunction. Symptoms include dryness, irritation, discomfort and visual disturbance, and standard treatment includes the use of lubricants and topical steroids. Secondary inflammation plays a prominent role in the development and propagation of this debilitating condition. To address this we have investigated the pilot scale development of an innovative drug delivery system using a dexamethasone-encapsulated cholesterol-Labrafac™ lipophile nanostructured lipid carrier (NLC)-based ophthalmic formulation, which could be developed as an eye drop to treat DED and any associated acute exacerbations. After rapid screening of a range of laboratory scale pre-formulations, the chosen formulation was prepared at pilot scale with a particle size of 19.51 ± 0.5 nm, an encapsulation efficiency of 99.6 ± 0.5%, a PDI of 0.08, and an extended stability of 6 months at 4 °C. This potential ophthalmic formulation was observed to have high tolerability and internalization capacity for human corneal epithelial cells, with similar behavior demonstrated on ex vivo porcine cornea studies, suggesting suitable distribution on the ocular surface. Further, ELISA was used to study the impact of the pilot scale formulation on a range of inflammatory biomarkers. The most successful dexamethasone-loaded NLC showed a 5-fold reduction of TNF-α production over dexamethasone solution alone, with comparable results for MMP-9 and IL-6. The ease of formulation, scalability, performance and biomarker assays suggest that this NLC formulation could be a viable option for the topical treatment of DED.
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Kim, Sung-Jin, Bongkyun Park, Hyun Wook Huh, et al. "Achyranthis radix Extract-Loaded Eye Drop Formulation Development and Novel Evaluation Method for Dry Eye Treatment." Pharmaceutics 12, no. 2 (2020): 165. http://dx.doi.org/10.3390/pharmaceutics12020165.
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Recently, Achyranthis radix extract has been studied as a therapeutic agent for dry eye disease that occurs from fine dust. The aim of this study was the development of Achyranthis radix extract-loaded eye drop formulations using lubricants, generally used for artificial tear eye drops. Ecdysterone was used as a marker compound for Achyranthis radix extract and 1% Achyranthis radix extract solution contained 14.37 ± 0.04 μg/mL of ecdysterone. Before formulation studies, a new method was performed to evaluate pigmentation, which might be caused by eye drops of herbal extract. A comparative study of the water retention ability of each formulation and ability to prevent the death of conjunctival epithelial cells in dry conditions was conducted. Moreover, treatment of Achyranthis radix extract (USL) eye drop formulation exhibited a significant inhibitory effect on inflammation in a concentration-dependent manner. The long-term and accelerated stability tests showed that lubricants could contribute to the stability of herbal extracts in solution. In conclusion, hyaluronic acid showed a good effect on the development of eye drop formulation using Achyranthis radix extracts for treating dry eye disease.
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Mehta, Tanu, Saeed Najafian, Komalkumar Patel, Justin Lacombe, and Bodhisattwa Chaudhuri. "Optimization of Carrier-Based Dry Powder Inhaler Performance: A Review." Pharmaceutics 17, no. 1 (2025): 96. https://doi.org/10.3390/pharmaceutics17010096.
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Dry powder inhalers (DPI’s) are becoming increasingly popular due to growing interest in pulmonary drug delivery and their performance is the net result of a series of processes carried out during the formulation development and manufacturing process such as excipient selection, blending, milling, filling, and spray drying. To reach the small airways of the deep lung, the active pharmaceutical ingredients (API) particles need to have an aerodynamic diameter of 1–5 μm to avoid impaction and particle sedimentation in the upper respiratory tract, and due to this small particle size, the powder becomes highly cohesive resulting in poor flow. Therefore, API is usually blended with a coarse carrier to improve flowability, and due to its large size, it is more fluidizable than the micronized drug. Carrier-based DPI formulations usually consist of micronized drugs, a coarse carrier, and additional components, such as micronized lactose and force control agents, including magnesium stearate or leucine. Additionally, the manufacturing process of DPIs relies heavily on powder processing technologies, such as the micronization of API, blending, and powder filling. The aerosol performance of a DPI is significantly affected by the selection of formulation components and the processing of the formulation and, therefore, it is crucial to evaluate these parameters. This review will discuss different factors influencing the aerosol performance of carrier-based DPIs, including formulation components, device considerations, and manufacturing parameters. Additionally, novel technologies pertaining to the optimization of DPI performance are also discussed.
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Dischinger, Angela, Susanne Page, and Peter Kleinebudde. "Fast dissolving fillers in dry foam formulation." Powder Technology 270 (January 2015): 494–501. http://dx.doi.org/10.1016/j.powtec.2014.06.036.
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Brunaugh, Ashlee D., and Hugh D. C. Smyth. "Formulation techniques for high dose dry powders." International Journal of Pharmaceutics 547, no. 1-2 (2018): 489–98. http://dx.doi.org/10.1016/j.ijpharm.2018.05.036.
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Oancea, Florin, Iulia Raut, Tatiana Eugenia Şesan, and Petruţa Călina Cornea. "Dry Flowable Formulation of Biostimulants Trichoderma Strains." Agriculture and Agricultural Science Procedia 10 (2016): 494–502. http://dx.doi.org/10.1016/j.aaspro.2016.09.022.
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Gallarate, Marina, Elena Mittone, M. Eugenia Carlotti, Michele Trotta, and Philippe Piccerelle. "Formulation of Dry Emulsion for Topical Applications." Journal of Dispersion Science and Technology 30, no. 6 (2009): 823–33. http://dx.doi.org/10.1080/01932690802643998.
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Weers, Jeffry G., and Danforth P. Miller. "Formulation Design of Dry Powders for Inhalation." Journal of Pharmaceutical Sciences 104, no. 10 (2015): 3259–88. http://dx.doi.org/10.1002/jps.24574.
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Nawghare, Vaishnavi. "Formulation and Evaluation of Polyherbal Dry Shampoo." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 09, no. 06 (2025): 1–9. https://doi.org/10.55041/ijsrem50717.
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The Aim of the present research is to create and assess a herbal dry shampoo with natural components, focusing on its effectiveness and safety. Shampoos are used to preserve the manageability and oiliness of hair in addition to its washing properties. Shampoos come in several varieties, such as lotion shampoo, solid gel shampoo, medicinal shampoo, powder shampoo, clear liquid shampoo, liquid herbal shampoo, and more. Using conventional medications for hair treatment, the herbal shampoo powder was created in this experiment. In order to assess the preparation's organoleptic qualities, powder properties, foam test, and physical assessment, Shikakai, Reetha, Shatavari, fenugreek, curry laves and manjistha were used in its formulation. The prepared shampoo produced perfect results in the physicochemical analysis. However, further research and development were needed to enhance its quality, product performance, and safety. Shampoo is a hair care product that is packaged carefully for usage. Its purpose is to clean the hair and get rid of accumulated sebum, oils, grime, and debris from the scalp. For extended usage, the shampoo's ingredients needs to be both safe and effective. In addition, it acts as a conditioning agent, all of which helps without harming or destroying hair. General powder properties, physicochemical analysis, ash and alcohol solubility, and organoleptic investigations were performed on all three formulations (F1–F3). extractives, measuring moisture content, determining pH, cleaning efficacy, foaming capabilities, filth dispersion, soaking time, and research on the characteristics of cleansed hair. Keywords: polyherbal dry shampoo, Shikakai, Reetha, Shatavari, Fenugreek, Curry leaves and Manjistha.
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Gawshinde, Arpit Gawshinde. "Formulation, development and evaluation of paracetamol tablet by moisture activated dry granulation (MADG) process." Journal of Pharmaceutical and Biological Sciences 12, no. 1 (2024): 60–67. http://dx.doi.org/10.18231/j.jpbs.2024.010.
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Paracetamol, also known as acetaminophen, is a painkiller that is popular throughout the world because it does not irritate the stomach. Paracetamol was first discovered to have both analgesic and antipyretic properties in the late nineteenth century. The aim of present work was to Formulate, develop and evaluate Paracetamol Tablets by Moisture Activated Dry Granulation (MADG) process to short manufacturing time and process variables as compared with convention process. Colloidal anhydrous silica is used in the formulation to absorb the extra moisture present in the MADG process formulation. A total number of five formulations were prepared and weight of all tablets kept constant. i.e. 595 mg.All the formulations resulted in acceptable limit. The final batch F3 (contained PVPK 3% and Kollidon 90F 4%) considered as optimized batch which gives the release up to 95.38 % in 30 min. All Pre-compression parameters like Carr’s Index, Hausner’s Ratio and Angle of Repose met the standard values indicating good flow properties. The average weight, friability and hardness were within compendia limits. Drug content uniformity was within acceptable limits. The result of stability study of the batch F3 showed that there was no significant change in Hardness, Friability, In-vitro Disintegration time, The optimized formulation batch F3 showed better drug release profile with other formulations.The PCM tablets prepared by MADG process had advantages such as short manufacturing time and few critical formulation and process variables when compared with convention wet granulation process.
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Adhikari, Bishal Raj, Kārlis Bērziņš, Sara J. Fraser-Miller, Keith C. Gordon, and Shyamal C. Das. "Co-Amorphization of Kanamycin with Amino Acids Improves Aerosolization." Pharmaceutics 12, no. 8 (2020): 715. http://dx.doi.org/10.3390/pharmaceutics12080715.
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Different formulation techniques have been investigated to prepare highly aerosolizable dry powders to deliver a high dose of antibiotics to the lung for treating local infections. In this study, we investigated the influence of the co-amorphization of a model drug, kanamycin, with selected amino acids (valine, methionine, phenylalanine, and tryptophan) by co-spray drying on its aerosolization. The co-amorphicity was confirmed by thermal technique. The physical stability was monitored using low-frequency Raman spectroscopy coupled with principal component analysis. Except for the kanamycin-valine formulation, all the formulations offered improved fine particle fraction (FPF) with the highest FPF of 84% achieved for the kanamycin-methionine formulation. All the co-amorphous formulations were physically stable for 28 days at low relative humidity (25 °C/<15% RH) and exhibited stable aerosolization. At higher RH (53%), even though methionine transformed into its crystalline counterpart, the kanamycin-methionine formulation offered the best aerosolization stability without any decrease in FPF. While further studies are warranted to reveal the underlying mechanism, this study reports that the co-amorphization of kanamycin with amino acids, especially with methionine, has the potential to be developed as a high dose kanamycin dry powder formulation.
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Mohan, Abhinav Ram, Qiang Wang, Sneha Dhapare, et al. "Advancements in the Design and Development of Dry Powder Inhalers and Potential Implications for Generic Development." Pharmaceutics 14, no. 11 (2022): 2495. http://dx.doi.org/10.3390/pharmaceutics14112495.
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Dry powder inhalers (DPIs) are drug–device combination products where the complexity of the formulation, its interaction with the device, and input from users play important roles in the drug delivery. As the landscape of DPI products advances with new powder formulations and novel device designs, understanding how these advancements impact performance can aid in developing generics that are therapeutically equivalent to the reference listed drug (RLD) products. This review details the current understanding of the formulation and device related principles driving DPI performance, past and present research efforts to characterize these performance factors, and the implications that advances in formulation and device design may present for evaluating bioequivalence (BE) for generic development.
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Krishna Sailaja, A. "Formulation Of Herbal Cream to Treat Dry Skin." Dermatology and Dermatitis 8, no. 3 (2023): 01–03. http://dx.doi.org/10.31579/2578-8949/119.
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The main aim of the present article is to reduce the adverse effect associated with synthetic dry skin cream by formulating an herbal dry skin cream for treatment of dry skin. Abnormally dry skin Can be occurring due to a dry weather, winter weather, acute deficiency of vitamin A, systemic illness, over exposure to sunlight, or medication. The skin loses moisture. It may crack and peel. Or it may become irritated, inflamed, and itch. Bathing repeatedly, especially with soaps, can contribute to dry skin. This research mainly based on the treatment of dry skin by using various herbs and making poly herbal formulation. Herbs such as cucumis sativus (main fruit juice) used as repair dry skin and damaged skin, moisturizer, azadirachta indica (neem leaves) used as skin moisturizer, rose water(rose water) used as cooling agent, flavouring agent, emollient, tulasi (tulasi leaves) used as antioxidant and skin texture improve, antimicrobial agent, amla (amla fruit) used as antioxidant and vitamin C help to brighten your skin, vitamin E used as moisturizer skin, lotus flower(lotus petals) used as anti-inflammatory and which help balance sebum production, improve the texture and elasticity of the skin, cool. Natural herbal extract in combination effectively utilized for the treatment of dry skin. Use of such product far better than the use of synthetic cream for the control of dry skin.
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Miyamoto, Kahori, Yuko Ishibashi, Tomomi Akita, and Chikamasa Yamashita. "Systemic Delivery of hGhrelin Derivative by Lyophilizate for Dry Powder Inhalation System in Monkeys." Pharmaceutics 13, no. 2 (2021): 233. http://dx.doi.org/10.3390/pharmaceutics13020233.
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Ghrelin is the peptide that increases the hunger sensation and food intake and is expected to be clinically applied for treatment of diseases such as cachexia and anorexia nervosa. In the clinical application of ghrelin, injections are problematic in that they are invasive and inconvenient. Thus, we aimed to develop a formulation that can eliminate the need for injections and can be applied clinically. We prepared formulations of an hGhrelin derivative, in which the octanoyl group essential for expression of activity is modified to avoid rapid des-acylation, using lyophilizate for a dry powder inhalation (LDPI) system. The formulation of hGhrelin derivative was optimized by the addition of phenylalanine, of which the fine particle fraction of 5 µm or less was 41.7 ± 3.8%. We also performed pharmacokinetic/pharmacodynamic tests in monkeys using the optimum formulation that can be applied clinically. The absolute bioavailability of inhaled hGhrelin derivative with respect to that intravenously injected was 16.9 ± 2.6%. An increase in growth hormone was shown as an effect of the inhaled hGhrelin derivative similar to intravenous injection. The LDPI formulation can deliver the hGhrelin derivative systemically, and it is expected to be applied clinically as a substitute for injections.
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Jordan, David L., Ann B. Burns, C. Jeff Barnes, Wayne Barnett, and J. Kelly Herrick. "Influence of Adjuvants and Formulation on Barnyardgrass (Echinochloa crus-galli) Control with Propanil in Rice (Oryza sativa)." Weed Technology 11, no. 4 (1997): 762–66. http://dx.doi.org/10.1017/s0890037x00043402.
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Experiments were conducted to compare barnyardgrass control and rice injury and yield with emulsifiable concentrate and dry flowable formulations of propanil as single or repeat applications with crop oil concentrate, methylated seed oil, a blend of organosilicone surfactant and methylated seed oil or conventional nonionic surfactant, and organosilicone surfactant. Two applications of propanil were more effective in controlling barnyardgrass than a single application. The emulsifiable concentrate formulation of propanil controlled barnyardgrass more effectively than the dry flowable formulation in some but not all experiments. Differences in barnyardgrass control with propanil as influenced by adjuvants were minor and inconsistent. The most consistent barnyardgrass control and the highest rice yields were obtained with repeat applications of the emulsifiable concentrate formulation of propanil.
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Hosseinpourpia, Reza, Stergios Adamopoulos, Thomas Walther, and Valeri Naydenov. "Hydrophobic Formulations Based on Tall Oil Distillation Products for High-Density Fiberboards." Materials 13, no. 18 (2020): 4025. http://dx.doi.org/10.3390/ma13184025.
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This study investigates the effect of renewable formulations based on tall oil bio-refinery products on the water vapor sorption and interfiber strength of cellulosic fibers as well as on the properties of high-density fiberboard (HDF) panels. The results obtained for HDF prepared using renewable formulations were compared to the results for HDF obtained using conventional synthetic paraffin wax (hydrowax), which is the hydrophobic agent currently utilized by the industry. Four tall oil distillation products (TODPs) with different levels of fatty and rosin acids were used for preparing the hydrophobic formulations with furfuryl alcohol as an organic solvent. According to determinations with an automated vapor sorption apparatus, the formulations had a similar effect with hydrowax on the sorption behavior of natural fibers. Unlike to hydrowax treatment, the ultimate tensile strength of cellulosic paper-sheets treated with the formulations remained unchanged or significantly increased. At the standard addition load of 1% (wt/wt dry fibers) of the formulations, HDF panels showed comparable and only in one case, e.g., TODP3-based formulation, slightly higher thickness swelling (24 h) than those with hydrowax. The best performing formulation (TODP2-based) in terms of tensile strength of paper sheets did not significantly change the mechanical properties of HDF panels in both standard climate and high humid conditions. Promising results at the standard and humid climate conditions were obtained for HDF panels manufactured with higher TODP2-based formulation amounts (3–5%) and reduced melamine-urea-formaldehyde resin content (10–12% instead of 14%, wt dry resin/wt dry fibers).
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Spahn, Jamie E., Amr Hefnawy, Feng Zhang, and Hugh D. C. Smyth. "Feasibility of a High-Dose Inhaled Indomethacin Dry Powder with Dual Deposition for Pulmonary and Oral Delivery." Pharmaceutics 16, no. 10 (2024): 1269. http://dx.doi.org/10.3390/pharmaceutics16101269.
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In this study we have developed a high-dose dry powder inhaler formulation of indomethacin using a novel approach to carrier-based formulations. Specifically, larger drug particles serve as the carrier for the smaller micronized drug particles, such that an inhaled dose is combined with an oral dose. To study this system, the aerosol performance of a standard indomethacin–lactose formulation was compared to carrier-free micronized indomethacin and a drug-as-carrier formulation (a micronized indomethacin–coarse indomethacin blend). Indomethacin with lactose showed a very poor aerosol performance, indicating high adhesion between the drug and carrier. The performance of the carrier-free micronized drug was significantly better, indicating low cohesion. Coarse drug particles as a carrier allowed improved powder flow and aerosol performance while also providing a potential secondary route of absorption of indomethacin, namely oral. An optimal formulation ratio of 1:1 (w/w) fine indomethacin–coarse indomethacin was developed in this study.
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Buhler, Douglas D., William C. Koskinen, Marvin M. Schreiber, and Jianying Gan. "Dissipation of Alachlor, Metolachlor, and Atrazine from Starch-Encapsulated Formulations in a Sandy Loam Soil." Weed Science 42, no. 3 (1994): 411–17. http://dx.doi.org/10.1017/s0043174500076700.
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Research was conducted to determine the effect of starch encapsulation on soil dissipation and weed control with alachlor, metolachlor, and atrazine on an Estherville sandy loam in the field. Starch encapsulation increased persistence of alachlor in the surface 15 cm of soil compared to the emulsifiable concentrate formulation during the first 60 d after treatment More alachlor was detected 30 to 75 cm deep with emulsifiable concentrate than the starch-encapsulated formulation 30 d after treatment. Little alachlor was detected below 15 cm thereafter. Starch encapsulation also increased persistence of metolachlor in the surface 15 cm, but reduced concentrations at 15 to 30 cm compared to the emulsifiable concentrate 30 d after treatment. By 120 and 340 d after treatment, metolachlor concentrations at 15 to 30 cm were greater with starch-encapsulated than emulsifiable concentrate formulation. Starch encapsulation greatly increased atrazine persistence in the surface 15 cm compared to the dry flowable formulation. Although encapsulation increased atrazine concentration in the surface 15 cm, it reduced the concentration below 15 cm compared to the dry flowable formulation 30 and 60 d after treatment However, by 120 and 340 d after treatment, starch encapsulation often resulted in greater atrazine concentrations below 15 cm than the dry flowable formulation. Control of green foxtail and redroot pigweed with starch-encapsulated herbicides was similar or superior to the commercial formulations.
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Chomto, Parichat, Gaysorn Chansiri, Khaw-on Tepsukon, Pawitra Yodwandee, Porntipa Laovanichkul, and Somlak Kongmuang. "Formulation of Cold Pressed-Coconut Oil Dry Emulsion." Advanced Materials Research 1060 (December 2014): 91–94. http://dx.doi.org/10.4028/www.scientific.net/amr.1060.91.
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Development of stable dry emulsion capable to self- reform into emulsion by reconstitution in water is presented. The major compositions of oil in water (o/w) emulsion were cold pressed-coconut oil (or virgin coconut oil from four different companies) as oil phase and water as phase containing an emulsifier [hydroxypropylmethylcellulose (HPMC)] and a densifier or solid [tapioca starch (T)]. Dry emulsions were prepared by placing liquid emulsion in condition at 60 °C. The percentage yield of dry emulsion was between 59-62%. After sieving, the most flowability data of dry emulsion granules were passable as a result of some oily parts appeared in particles. The moisture contents in dry emulsion granule were relatively low. The antioxidant activity of oil, primary emulsion (PE) and reconstitute emulsion (RE) were also investigated with Trolox as standard. It was found that the order of antioxidant activity of coconut oil as decrease as following: oil, emulsion and reconstitute emulsion respectively. After 2 freeze-thaw cycles, all reconstituted emulsions were shown to be unstable. The four different brands of virgin coconut oil showed no significant different physical and antioxidant properties of PE and RE. Thus, the process of making a virgin coconut oil dry emulsion might not be affected by any different sources of virgin coconut oil.
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Eldesouky, Lubna M., Riham M. El-Moslemany, Alyaa A. Ramadan, Mahmoud H. Morsi, and Nawal M. Khalafallah. "Cyclosporine Lipid Nanocapsules as Thermoresponsive Gel for Dry Eye Management: Promising Corneal Mucoadhesion, Biodistribution and Preclinical Efficacy in Rabbits." Pharmaceutics 13, no. 3 (2021): 360. http://dx.doi.org/10.3390/pharmaceutics13030360.
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An ophthalmic cyclosporine (CsA) formulation based on Lipid nanocapsules (LNC) was developed for dry eye management, aiming to provide targeting to ocular tissues with long-term drug levels and maximum tolerability. CsA-LNC were of small particle size (41.9 ± 4.0 nm), narrow size distribution (PdI ≤ 0.1), and high entrapment efficiency (above 98%). Chitosan (C) was added to impart positive charge. CsA-LNC were prepared as in-situ gels using poloxamer 407 (P). Ex vivo mucoadhesive strength was evaluated using bovine cornea, while in vivo corneal biodistribution (using fluorescent DiI), efficacy in dry eye using Schirmer tear test (STT), and ocular irritation using Draize test were studied in rabbits compared to marketed ophthalmic CsA nanoemulsion (CsA-NE) and CsA in castor oil. LNC incorporation in in-situ gels resulted in an increase in mucoadhesion, and stronger fluorescence in corneal layers seen by confocal microscopy, compared to the other tested formulations. Rate of recovery (days required to restore corneal baseline hydration level) assessed over 10 days, showed that CsA-LNC formulations produced complete recovery by day 7 comparable to CsA-NE. No Ocular irritation was observed by visual and histopathological examination. Based on data generated, CsA-LNC-CP in-situ gel proved to be a promising effective nonirritant CsA ophthalmic formulation for dry eye management.
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Miyamoto, Kahori, Tomomi Akita, and Chikamasa Yamashita. "Radiolabeling Method for Lyophilizate for Dry Powder Inhalation Formulations." Pharmaceutics 14, no. 4 (2022): 759. http://dx.doi.org/10.3390/pharmaceutics14040759.
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Human lung deposition data is non-mandatory for drug approval but very useful for the development of orally inhaled drug products. Lung deposition of inhaled drugs can be quantified by radionuclide imaging, for which one of the first considerations is the method used to radiolabel formulations. In this study, we report the development of a radiolabeling method for lyophilizate for dry powder inhalation (LDPI) formulations. TechneCoatTM is one method that can radiolabel drug particles without using solvents. In this method, particles are radiolabeled with a dispersion of 99mTc-labeled nanoparticles called TechnegasTM. Because a LDPI formulation is not comprised of particles but is a lyophilized cake aerosolized by air impact, the TechneCoat method cannot be used for the radiolabeling of LDPI formulations. We therefore modified the TechneCoat apparatus so that LDPI formulations were not aerosolized by the Technegas flow. Radiolabeling using a modified TechneCoat apparatus was validated with model LDPI formulations of interferon alpha (IFN). IFN of 99mTc-unlabeled, IFN of 99mTc-labeled, and 99mTc of 99mTc-labeled LDPI formulations showed similar behavior, and differences from IFN of 99mTc-unlabeled LDPI formulations were within ±15% in aerodynamic particle size distribution measurement. Our radiolabeling method for LDPI formulations may be useful for the quantification of drug deposition in human lungs.
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Mueller, Thomas C. "Effect of Pyroxasulfone Formulation on Dissipation from a Winter Wheat Field in Tennessee." Weed Technology 31, no. 6 (2017): 822–27. http://dx.doi.org/10.1017/wet.2017.59.
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Field studies were conducted in 2014 and 2015 in Tennessee to examine pyroxasulfone dissipation under field conditions of winter wheat production. Three formulations were examined: (1) a single component active ingredient in an 85% dry flowable, (2) dry flowable formulation in combination of pyroxasulfone+flumioxazin, and (3) a liquid SC formulation of pyroxasulfone+carfentrazone. The liquid formulation is a suspo-emulsion. When averaged across the three studies, the DT 50 were 34.4, 30.2 and 29.9 d for pyroxasulfone plus carfentrazone, pyroxasulfone, and pyroxasulfone plus flumioxazin, respectively. These trends would indicate that formulation had little or no effect on pyroxasulfone dissipation in this experiment. Pyroxasulfone DT 50 in all studies ranged from a low of 15.4 d to a high of 53.3 d, and loss was more rapid under warm, moist conditions. These results indicate that pyroxasulfone would last long enough to provide residual weed control, but would not persist excessively to injure rotational crops.
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Mehdaoui, Hamza, Hamid Ait Abderrahmane, Clement de Loubens, Faïçal Nait Bouda, and Sofiane Hamani. "Dynamics of a Gel-Based Artificial Tear Film with an Emphasis on Dry Disease Treatment Applications." Gels 7, no. 4 (2021): 215. http://dx.doi.org/10.3390/gels7040215.
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This paper discusses the spreading of gel-based ophthalmic formulation on the cornea surface assumed to be flat. We show that gel-based formulations exhibit rheological behaviors that the Herschel–Bulkley model can describe. The continuity and momentum equations are solved numerically using the monofluid formulation and the volume-of-fluid (VOF) method. We investigated the influence of the rheological properties, namely the consistency, the yield stress, and the flow behavior index, on the spreading of a gel-based artificial tear over the cornea surface. We propose optimal values of these properties for efficient gel-based artificial tears.
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Tan, Zhi Ming, Gui Ping Lai, Manisha Pandey, et al. "Novel Approaches for the Treatment of Pulmonary Tuberculosis." Pharmaceutics 12, no. 12 (2020): 1196. http://dx.doi.org/10.3390/pharmaceutics12121196.
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Tuberculosis (TB) is a contagious airborne disease caused by Mycobacterium tuberculosis, which primarily affects human lungs. The progression of drug-susceptible TB to drug-resistant strains, MDR-TB and XDR-TB, has become worldwide challenge in eliminating TB. The limitations of conventional TB treatment including frequent dosing and prolonged treatment, which results in patient’s noncompliance to the treatment because of treatment-related adverse effects. The non-invasive pulmonary drug administration provides the advantages of targeted-site delivery and avoids first-pass metabolism, which reduced the dose requirement and systemic adverse effects of the therapeutics. With the modification of the drugs with advanced carriers, the formulations may possess sustained released property, which helps in reducing the dosing frequency and enhanced patients’ compliances. The dry powder inhaler formulation is easy to handle and storage as it is relatively stable compared to liquids and suspension. This review mainly highlights the aerosolization properties of dry powder inhalable formulations with different anti-TB agents to understand and estimate the deposition manner of the drug in the lungs. Moreover, the safety profile of the novel dry powder inhaler formulations has been discussed. The results of the studies demonstrated that dry powder inhaler formulation has the potential in enhancing treatment efficacy.
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Meena, V. Pavane* Mrunal K. Shirsat Avinash V.Dhobale Deepak A. Joshi Gunesh N. Dhembre Parimal S. Ingale. "FORMULATION, DEVELOPMENT AND EVALUATION OF ORAL RECONSTITUTABLE DRY SYRUP." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 01 (2018): 483–91. https://doi.org/10.5281/zenodo.1161363.
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Taste masking and development of palatable dosage forms of bitter drugs constitutes the objective of many a research project in the field of pharmaceutical technology. Taste is an important factor in the development of dosage form. The problem of bitter and obnoxious taste of drug in pediatric patient can create a bad psychological effect on mind. The purpose of this research was to mask the intensely bitter taste of Ciprofloxacin is a broad spectrum antibiotic. It is extremely bitter taste resulting in poor patient’s compliance. The aim of present work was to prepare drug resin complex (DRC) using ion exchange resin (Indion 234) for taste masking and formulate oral reconstituable dry syrup of DRC. DRC was evaluated for effect of variables like drug resin ratio, pH, temperature, soaking time of resin and stirring time reconstituable dry syrup was prepared by using xanthan gum and microcrystalline cellulose as suspending agent formulated recostituable dry syrup was evaluated for before reconstitution parameters like flow properties, particle size and drug content and after reconstitution parameter like sedimentation rate redispercibility particle size, viscosity, pH and drug content. Formulated ciprofloxacin reconstituable dry syrup has acceptable sedimentation properties. In evaluating period of 14 days no significant change was observed in pH, viscosity, particle size and drug content.From the results it concluded that effective taste masking of ciprofloxacin was achieve using indion 234 and successfully evaluated in reconstituable dry syrup. Key Words: Sedimentation rate, Ion exchange resin, Stability, Ciprofloxacin, Indion 234, Acacia, Tragacanth, Sodium carboxy methyl cellulose.
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Malek, Walid A. A., Olena Anatoliivna Ruban, Olga V. Kutova, and Nataliia A. Herbina. "Optimization of tablet formulation containing ginger dry extract." Current Issues in Pharmacy and Medical Sciences 33, no. 2 (2020): 90–93. http://dx.doi.org/10.2478/cipms-2020-0018.
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AbstractIntroduction. Diabetes mellitus is one of the world’s most common diseases, therefore the development and introduction of new effective drugs for diabetes treatment into clinical practice is an important task for the health systems of many countries of the world.Aim. The aim of our work was to determine and substantiate the quantitative ratio of excipients for the development of the optimal composition of directly compressible ginger dry extract tablets.Materials and methods. To choose the optimal composition of tablets containing ginger dry extract, the effect of various quantitative ratios of the excipients Kollidon K30 and Neusilin UFL 2 on tablet mass pharmaceutical technical parameters, determined by established methods, was studied. For processing the experimental data, mathematical methods were used: design of experiment, regression analysis and a technique based on the theory of vector optimization.Results. The interrelation between factors that were studied and technological parameters of tablet mass and compressed tablets were analyzed using regression equations.Conclusions. The studies conducted allowed to chose the optimal composition of ginger dry extract tablets: ginger dry extract – 60%, Galen IQ 721 – 34.5%, Kollidon K30 – 3.5%, Neusilin UFL 2 – 1%, calcium stearate – 1%. The chosen tablet formulation is characterized by pharmaceutical technical parameters meeting the requirements of the European Pharmacopoeia and the State Pharmacopoeia of Ukraine.
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Tamboli, Firoj A., Sajid A. Mulani, Nitin Mali, et al. "Formulation and evaluation of dry herbal powder shampoo." International Journal of Pharmaceutical Chemistry and Analysis 8, no. 3 (2021): 112–17. http://dx.doi.org/10.18231/j.ijpca.2021.022.
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Shampoos are used not only for cleansing purpose but also for imparting gloss to hair and to maintain their manageability and oiliness for hair. Shampoos are of various types, like powder shampoo, clear liquid shampoo liquid shampoo, lotion shampoo, solid gel shampoo, medicated shampoo, liquid herbal shampoo etc. As far as herbal shampoos are concerned in stability criteria. Depending upon the nature of the ingredients they may be simple or plain shampoo, antiseptic or antidandruff.In the present work the herbal shampoo powder has been developed, by using traditional drugs for hair care. The preparation were formulated using Onion Powder, Rose Petal, Lemon Grass, Flaxseed or Linseed, Hirda, Bahera, Black tea, Brahmni, Triphala, Bhringraj, Ginger Root, Ashwagadha, Shikakai, Feenu greek, Shatavari, Heena, Wala, Aloevera Powder, Nirgudi Powder, Bavachi, Jatha mansi, Tulsi, Neem, Hibiscus Flower, and Retha evaluated for organoleptic properties, powder characteristics, foam test and physical evaluation.The physicochemical evaluation of the formulated shampoo showed ideal results. However, to improve its quality, product performance, and safety, further development and study was required.
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Ziffels, Susanne, Norman L. Bemelmans, Phillip G. Durham, and Anthony J. Hickey. "In vitro dry powder inhaler formulation performance considerations." Journal of Controlled Release 199 (February 2015): 45–52. http://dx.doi.org/10.1016/j.jconrel.2014.11.035.
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Shi, Lianjun, Carl J. Plumley, and Cory Berkland. "Biodegradable Nanoparticle Flocculates for Dry Powder Aerosol Formulation." Langmuir 23, no. 22 (2007): 10897–901. http://dx.doi.org/10.1021/la7020098.
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Lu, Tianshu, Shihao Xu, Hao Zhong, et al. "Computer-driven formulation development of dipyridamole dry nanosuspension." International Journal of Pharmaceutics 679 (June 2025): 125739. https://doi.org/10.1016/j.ijpharm.2025.125739.
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Rastegari, Ali, Zohreh Mohammadi, Homa Faghihi, and Sanaz Rezaei. "Preparation and Physicochemical Evaluation of Eye Drop Formulation Based on Hyaluronic Acid and Vitamin B12." Journal of Guilan University of Medical Sciences 33, no. 02 (2024): 176–87. http://dx.doi.org/10.32598/jgums.33.2.1973.1.
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Background Dry eye disease is a common age-related disease in the world. Vitamin B12 is an essential factor in maintaining eye health and has antioxidant properties that protect the surface of the eye from damage caused by harmful factors, such as reactive oxygen species. Hyaluronic acid polymer is also similar to natural eye tears with its biocompatibility and physical properties. This polymer is one of the important components of the extracellular matrix. Objective Due to the lack of formulations containing the combination of vitamin B12 and hyaluronic acid in the country and the appropriate effects of these two compounds for dry eyes, this study formulates and analyzes the stability of eye drop formulation based on hyaluronic acid and vitamin B12. Methods First, the formulation of hyaluronic acid and vitamin B12 solution with borate buffer was prepared and the stability of vitamin B12 was evaluated. Next, the physicochemical properties of the prepared formulations were evaluated and a sterile ophthalmic solution was prepared from the selected formulations under aseptic conditions. Finally, by choosing the final formulation, accelerated stability was achieved. Results Accelerated studies after six months showed that the amount of vitamin B12 and its ultraviolet absorption did not decrease, and the physicochemical properties, such as solution pH, color, and viscosity did not change. Conclusion This formulation could be a good candidate for industrial production and long-term stability studies are recommended.
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Ruter, John M. "EFFECT OF PACLOBUTRAZOL FORMULATION ON THE GROWTH AND FLOWERING OF BUDDLEIA DAVIDII 'DUBONNET'." HortScience 27, no. 11 (1992): 1174e—1174. http://dx.doi.org/10.21273/hortsci.27.11.1174e.
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Granular and liquid formulations of paclobutrazol were tested to evaluate the growth and flowering response of butterfly bush (Buddleia davidii Franch. 'Dubonnet'). At the rates tested (5, 10, 20, and 40 mg ai·pot–1), the granular formulation reduced the growth index, plant height, shoot dry weight, total plant biomass, number of panicles and panicle length to a greater degree than the liquid formulation applied as a drench. Both formulations reduced total plant biomass and increased the root:shoot ratio compared to the control. All rates of the granular formulation above 5 mg ai · pot–1 produced non-marketable plants. Since no phytotoxicity was observed with any treatment, the application of paclobutrazol to control the growth of butterfly-bush may be useful if the correct formulation and rate of application are chosen.
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Dr., M. Sunitha Reddy* and Anusha Kunduru. "FORMULATION AND IN-VITRO EVALUATION OF GLIBENCLAMIDE DRY EMULSION IN VEGETARIAN CAPSULES." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 3869–73. https://doi.org/10.5281/zenodo.1040752.
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The purpose of this study is to improve the bioavailability and dissolution of Glibenclamide in the preparation of a dried emulsion. This dry emulsion formulation is filled in HPMC capsules as it is of vegetarian source but not gelatin because of several drawbacks. The animal source of gelatin may be a problem for some consumers, such as vegetarian and religious groups or ethical groups, since unmodified gelatin is subjected to cross linking in contact with aldehydes, solubility problems can be expected with certain fill formulations. Dry emulsions are prepared by the drying of liquid emulsions in which there is a solid form in the aqueous phase. The solid support provides the dry and bulk emulsions. In this preparation the emulsion was dried, sesame oil in which the drug is soluble, hydroxyl propyl methyl cellulose as the organic filler and Tween 80 as the surfactant is used. The dried emulsion was evaluated for the drug content, determination of the globular size and surface characterization, in vitro release of the drug in dry emulsion was studied by a type II USP-type paddle dissolving apparatus. This study revealed that the solid dry emulsion technique proved to be promising and useful for improving dissolution. Key Words: Glibenclamide, Dry Emulsion, HPMC capsules, Sesame oil
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Eedara, Basanth Babu, Rakesh Bastola, and Shyamal C. Das. "Dissolution and Absorption of Inhaled Drug Particles in the Lungs." Pharmaceutics 14, no. 12 (2022): 2667. http://dx.doi.org/10.3390/pharmaceutics14122667.
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Dry powder inhalation therapy has been effective in treating localized lung diseases such asthma, chronic obstructive pulmonary diseases (COPD), cystic fibrosis and lung infections. In vitro characterization of dry powder formulations includes the determination of physicochemical nature and aerosol performance of powder particles. The relationship between particle properties (size, shape, surface morphology, porosity, solid state nature, and surface hydrophobicity) and aerosol performance of an inhalable dry powder formulation has been well established. However, unlike oral formulations, there is no standard dissolution method for evaluating the dissolution behavior of the inhalable dry powder particles in the lungs. This review focuses on various dissolution systems and absorption models, which have been developed to evaluate dry powder formulations. It covers a summary of airway epithelium, hurdles to developing an in vitro dissolution method for the inhaled dry powder particles, fine particle dose collection methods, various in vitro dissolution testing methods developed for dry powder particles, and models commonly used to study absorption of inhaled drug.