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Relevant bibliographies by topics / Dry Granulation scale-up

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Journal articles
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Academic literature on the topic 'Dry Granulation scale-up'

Author: Grafiati

Published: 10 September 2021

Last updated: 29 July 2025

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Journal articles on the topic "Dry Granulation scale-up"

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Jang, Eun Ha, Yun Sang Park, Min-Soo Kim, and Du Hyung Choi. "Model-Based Scale-up Methodologies for Pharmaceutical Granulation." Pharmaceutics 12, no. 5 (2020): 453. http://dx.doi.org/10.3390/pharmaceutics12050453.

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In the pharmaceutical industry, it is a major challenge to maintain consistent quality of drug products when the batch scale of a process is changed from a laboratory scale to a pilot or commercial scale. Generally, a pharmaceutical manufacturing process involves various unit operations, such as blending, granulation, milling, tableting and coating and the process parameters of a unit operation have significant effects on the quality of the drug product. Depending on the change in batch scale, various process parameters should be strategically controlled to ensure consistent quality attributes

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Berman, J., P. Pierce, and P. E. Page. "Scale-Up of a Spray Dry Tablet Granulation Process: Thermodynamic Considerations." Drug Development and Industrial Pharmacy 20, no. 5 (1994): 731–55. http://dx.doi.org/10.3109/03639049409038328.

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Abrosimova, O. N., and M. A. Burakova. "Scaling of the Granulation Process in the Conditions of GMP Training Center and Assessment of Possible Risks." Drug development & registration 10, no. 3 (2021): 131–37. http://dx.doi.org/10.33380/2305-2066-2021-10-3-131-137.

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Introduction. The stage of wet granulation is often used in the technology of solids. The method of wet granulation in a mixer-granulator with high shear force can be regarded as the most complicated method of its implementation from the engineering and technological point of view. The mixer-granulator has two mixers located in mutually perpendicular planes. Using an impeller, dry components are mixed, and the chopper, turning on when spraying a humidifier, ensures the formation of granules. By setting different chopper rotational speed, granules of different sizes can be obtained. This granul

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Dhirhi, Ravindra, Kali Prasad, Ajay Kumar Shukla, et al. "Experimental study of rotating dry slag granulation unit: Operating regimes, particle size analysis and scale up." Applied Thermal Engineering 107 (August 2016): 898–906. http://dx.doi.org/10.1016/j.applthermaleng.2016.07.049.

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Shete, Nikhil Arun, Vishwajeet Swami, Vaibhav Kulkarni, Gajanan Paratkar, and Rahul Mohan. "Optimization of Process Parameters for Formulation of Fluvastatin Tablet by Using Dry Granulation Method." Journal of Drug Delivery and Therapeutics 10, no. 5-s (2020): 97–107. http://dx.doi.org/10.22270/jddt.v10i5-s.4347.

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The manufacturing process of the tablet is a very complex process; it can be affected by the several process parameters or variables. The aim of this study was to understand and optimize the process parameters such as mixing, granulation, lubrication and tablets compression processes using quality by design (QbD) approach for a model Anti- Hyperlipidemic drug Fluvastatin sodium. During the processes there are several parameters which may influence or affect product quality. So the main objective of present work was to identify various process parameters and optimize this parameter, for the for

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Jena, Tapan Kumar, and Rakesh Kumar Jat. "Formulation and Optimization of Immediate Release Tablet of Sapropterin Dihydrochloride by Dry Granulation Process." Journal of Drug Delivery and Therapeutics 14, no. 6 (2024): 105–8. http://dx.doi.org/10.22270/jddt.v14i6.6583.

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The research aims to develop and evaluate an immediate-release dosage form of sapropterin dihydrochloride to improve efficacy, stability, and patient acceptance in treating hyperphenylalaninemia (HPA), ensuring rapid therapeutic action upon administration. Formulation development began with a pre-formulation study to evaluate drug-excipient compatibility, solubility, and compressibility, followed by feasibility trials to create a prototype formulation. Dissolution tests and optimization methods, including DoE and OFAT, were employed to refine the formulation based on critical quality attribute

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Hindocha, S., and S. Poulston. "Study of the scale-up, formulation, ageing and ammonia adsorption capacity of MIL-100(Fe), Cu-BTC and CPO-27(Ni) for use in respiratory protection filters." Faraday Discussions 201 (2017): 113–25. http://dx.doi.org/10.1039/c7fd00090a.

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The metal–organic frameworks (MOFs) MIL-100(Fe), Cu-BTC and CPO-27(Ni) were synthesised in 1 kg batches. The materials were then formed in two different industrially relevant ways. Firstly, dry granulation was used to produce pellets which were sieved to give material with a 300–1000 μm size, and the fines were subsequently recycled to mimic a large scale industrial process. Secondly, wet granulation with a polymer was used to produce granules which were again sieved to 300–1000 μm. XRD data shows that the structures of MIL-100(Fe) and CPO-27(Ni) remain intact during both forming processes, wh

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Welper, Lana L., Shihwu Sung, and Richard R. Dague. "Laboratory studies on the temperature-phased ASBR system." Water Science and Technology 36, no. 2-3 (1997): 295–302. http://dx.doi.org/10.2166/wst.1997.0542.

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Treatment of high-strength industrial wastewater with the temperature-phased anaerobic sequencing batch reactor (ASBR) system has shown positive results in laboratory scale studies. The system achieved COD removals as high as 95% and 90% for soluble and total COD, respectively, up to COD loadings of 22 g COD/L/day. Non-fat dry milk was used as a synthetic substrate. The system consisted of two reactors operated in series at different temperatures. Phase I of the system was operated at 55°C and the Phase II was operated at 35°C. The total hydraulic retention time in the system was 18 hours (6 h

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S. S, Dharaneesh, J. Sridhar, Dhinesh Kumar, Premnath Premnath, Abhiram Kanth, and Sudhan S. "Comparison of Vacuum-Assisted Closure (VAC) Therapy and Conventional Dressing on Wound Healing in Diabetic Foot Ulcer: A Randomized Controlled Trial." Journal of Neonatal Surgery 14, no. 5S (2025): 499–508. https://doi.org/10.52783/jns.v14.2087.

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Background: Diabetic foot ulcers (DFUs) represent one of the most serious complications of diabetes mellitus, leading to prolonged morbidity, reduced quality of life, and an increased risk of lower limb amputation. India, being home to one of the highest populations of diabetics globally, faces a growing burden of DFUs. Conventional dressing has been the standard treatment for DFUs, but it is associated with prolonged healing time and a substantial risk of infection. Vacuum-Assisted Closure (VAC) therapy, a negative pressure wound therapy (NPWT), has emerged as a promising alternative for fast

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Hashimoto, S., K. Nishimura, H. Iwabu, and K. Shinabe. "Pilot Plant Test of Electron-Beam Disinfected Sludge Composting." Water Science and Technology 23, no. 10-12 (1991): 1991–99. http://dx.doi.org/10.2166/wst.1991.0655.

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A pilot plant was built to get information on scale-up factors of composting plant of electron-beam disinfected sludge cake. The amount of sludge to be treated was about 500 kg/batch. A Cockcroft-Walton type of electron accelerator and a machine to make thin layer of sludge were used for sludge disinfection. The composting plant consisted of a mixer, a granulating machine, a fermenter with three screw-type mixing blades, and a conveyer system. Efficient composting could be realized also by the pilot plant, by controlling fermentation temperature in the optimum range, by controlling air flow ra

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Dissertations / Theses on the topic "Dry Granulation scale-up"

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Schmidtke, Robert [Verfasser]. "Dry granulation via roller compaction : investigation on scale up strategies integrating process parameters and critical material attributes / Robert Schmidtke." Bonn : Universitäts- und Landesbibliothek Bonn, 2018. http://d-nb.info/116146221X/34.

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Souihi, Nabil. "Multivariate Synergies in Pharmaceutical Roll Compaction : The quality influence of raw materials and process parameters by design of experiments." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96441.

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Roll compaction is a continuous process commonly used in the pharmaceutical industry for dry granulation of moisture and heat sensitive powder blends. It is intended to increase bulk density and improve flowability. Roll compaction is a complex process that depends on many factors, such as feed powder properties, processing conditions and system layout. Some of the variability in the process remains unexplained. Accordingly, modeling tools are needed to understand the properties and the interrelations between raw materials, process parameters and the quality of the product. It is important to

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Saramago, Artur Rafael Servo Nunes Duarte. "Tablets manufacturing – Direct Scale-up from Lab to Manufacturing Facilities." Master's thesis, 2020. http://hdl.handle.net/10362/113511.

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Nowadays, oral dosage forms are the preferred drug delivery route. Concerning tablets as drug delivery systems, some solubility and flowability problems often arise, which can be fixed by manufacturing amorphous solid dispersions (ASD) and/or tablets via granulation (wet or dry) techniques. In this work, HPMCAS and PVPVA, typically selected polymers for ASD production, were incorporated in a standard formulation suitable for a dry granulation process. Generally, the process consists of ASD manufacturing via spray drying (SD), intragranular blending, roller compaction (RC) (includes compaction

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Book chapters on the topic "Dry Granulation scale-up"

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Sprockel, Omar L., and Howard J. Stamato. "Design and Scale-Up of Dry Granulation Processes." In Chemical Engineering in the Pharmaceutical Industry. John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470882221.ch38.

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Stamato, Howard J., and Omar L. Sprockel. "DESIGN AND SCALE-UP OF DRY GRANULATION PROCESSES." In Chemical Engineering in the Pharmaceutical Industry. John Wiley & Sons, Inc., 2019. http://dx.doi.org/10.1002/9781119600800.ch54.

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Am Ende, Mary T., Daniel O. Blackwood, Daniel S. Gierer, and Christopher P. Neu. "Challenges in Development and Scale-Up of Low-Dose Drug Products By Dry Granulation: A Case Study." In Formulation and Analytical Development for Low-Dose Oral Drug Products. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470386361.ch6.

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