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Journal articles on the topic 'Dry Granulation scale-up'

Author: Grafiati

Published: 10 September 2021

Last updated: 29 July 2025

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1

Jang, Eun Ha, Yun Sang Park, Min-Soo Kim, and Du Hyung Choi. "Model-Based Scale-up Methodologies for Pharmaceutical Granulation." Pharmaceutics 12, no. 5 (2020): 453. http://dx.doi.org/10.3390/pharmaceutics12050453.

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In the pharmaceutical industry, it is a major challenge to maintain consistent quality of drug products when the batch scale of a process is changed from a laboratory scale to a pilot or commercial scale. Generally, a pharmaceutical manufacturing process involves various unit operations, such as blending, granulation, milling, tableting and coating and the process parameters of a unit operation have significant effects on the quality of the drug product. Depending on the change in batch scale, various process parameters should be strategically controlled to ensure consistent quality attributes

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2

Berman, J., P. Pierce, and P. E. Page. "Scale-Up of a Spray Dry Tablet Granulation Process: Thermodynamic Considerations." Drug Development and Industrial Pharmacy 20, no. 5 (1994): 731–55. http://dx.doi.org/10.3109/03639049409038328.

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3

Abrosimova, O. N., and M. A. Burakova. "Scaling of the Granulation Process in the Conditions of GMP Training Center and Assessment of Possible Risks." Drug development & registration 10, no. 3 (2021): 131–37. http://dx.doi.org/10.33380/2305-2066-2021-10-3-131-137.

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Introduction. The stage of wet granulation is often used in the technology of solids. The method of wet granulation in a mixer-granulator with high shear force can be regarded as the most complicated method of its implementation from the engineering and technological point of view. The mixer-granulator has two mixers located in mutually perpendicular planes. Using an impeller, dry components are mixed, and the chopper, turning on when spraying a humidifier, ensures the formation of granules. By setting different chopper rotational speed, granules of different sizes can be obtained. This granul

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4

Dhirhi, Ravindra, Kali Prasad, Ajay Kumar Shukla, et al. "Experimental study of rotating dry slag granulation unit: Operating regimes, particle size analysis and scale up." Applied Thermal Engineering 107 (August 2016): 898–906. http://dx.doi.org/10.1016/j.applthermaleng.2016.07.049.

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5

Shete, Nikhil Arun, Vishwajeet Swami, Vaibhav Kulkarni, Gajanan Paratkar, and Rahul Mohan. "Optimization of Process Parameters for Formulation of Fluvastatin Tablet by Using Dry Granulation Method." Journal of Drug Delivery and Therapeutics 10, no. 5-s (2020): 97–107. http://dx.doi.org/10.22270/jddt.v10i5-s.4347.

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The manufacturing process of the tablet is a very complex process; it can be affected by the several process parameters or variables. The aim of this study was to understand and optimize the process parameters such as mixing, granulation, lubrication and tablets compression processes using quality by design (QbD) approach for a model Anti- Hyperlipidemic drug Fluvastatin sodium. During the processes there are several parameters which may influence or affect product quality. So the main objective of present work was to identify various process parameters and optimize this parameter, for the for

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6

Jena, Tapan Kumar, and Rakesh Kumar Jat. "Formulation and Optimization of Immediate Release Tablet of Sapropterin Dihydrochloride by Dry Granulation Process." Journal of Drug Delivery and Therapeutics 14, no. 6 (2024): 105–8. http://dx.doi.org/10.22270/jddt.v14i6.6583.

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The research aims to develop and evaluate an immediate-release dosage form of sapropterin dihydrochloride to improve efficacy, stability, and patient acceptance in treating hyperphenylalaninemia (HPA), ensuring rapid therapeutic action upon administration. Formulation development began with a pre-formulation study to evaluate drug-excipient compatibility, solubility, and compressibility, followed by feasibility trials to create a prototype formulation. Dissolution tests and optimization methods, including DoE and OFAT, were employed to refine the formulation based on critical quality attribute

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Hindocha, S., and S. Poulston. "Study of the scale-up, formulation, ageing and ammonia adsorption capacity of MIL-100(Fe), Cu-BTC and CPO-27(Ni) for use in respiratory protection filters." Faraday Discussions 201 (2017): 113–25. http://dx.doi.org/10.1039/c7fd00090a.

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The metal–organic frameworks (MOFs) MIL-100(Fe), Cu-BTC and CPO-27(Ni) were synthesised in 1 kg batches. The materials were then formed in two different industrially relevant ways. Firstly, dry granulation was used to produce pellets which were sieved to give material with a 300–1000 μm size, and the fines were subsequently recycled to mimic a large scale industrial process. Secondly, wet granulation with a polymer was used to produce granules which were again sieved to 300–1000 μm. XRD data shows that the structures of MIL-100(Fe) and CPO-27(Ni) remain intact during both forming processes, wh

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8

Welper, Lana L., Shihwu Sung, and Richard R. Dague. "Laboratory studies on the temperature-phased ASBR system." Water Science and Technology 36, no. 2-3 (1997): 295–302. http://dx.doi.org/10.2166/wst.1997.0542.

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Treatment of high-strength industrial wastewater with the temperature-phased anaerobic sequencing batch reactor (ASBR) system has shown positive results in laboratory scale studies. The system achieved COD removals as high as 95% and 90% for soluble and total COD, respectively, up to COD loadings of 22 g COD/L/day. Non-fat dry milk was used as a synthetic substrate. The system consisted of two reactors operated in series at different temperatures. Phase I of the system was operated at 55°C and the Phase II was operated at 35°C. The total hydraulic retention time in the system was 18 hours (6 h

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9

S. S, Dharaneesh, J. Sridhar, Dhinesh Kumar, Premnath Premnath, Abhiram Kanth, and Sudhan S. "Comparison of Vacuum-Assisted Closure (VAC) Therapy and Conventional Dressing on Wound Healing in Diabetic Foot Ulcer: A Randomized Controlled Trial." Journal of Neonatal Surgery 14, no. 5S (2025): 499–508. https://doi.org/10.52783/jns.v14.2087.

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Background: Diabetic foot ulcers (DFUs) represent one of the most serious complications of diabetes mellitus, leading to prolonged morbidity, reduced quality of life, and an increased risk of lower limb amputation. India, being home to one of the highest populations of diabetics globally, faces a growing burden of DFUs. Conventional dressing has been the standard treatment for DFUs, but it is associated with prolonged healing time and a substantial risk of infection. Vacuum-Assisted Closure (VAC) therapy, a negative pressure wound therapy (NPWT), has emerged as a promising alternative for fast

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10

Hashimoto, S., K. Nishimura, H. Iwabu, and K. Shinabe. "Pilot Plant Test of Electron-Beam Disinfected Sludge Composting." Water Science and Technology 23, no. 10-12 (1991): 1991–99. http://dx.doi.org/10.2166/wst.1991.0655.

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A pilot plant was built to get information on scale-up factors of composting plant of electron-beam disinfected sludge cake. The amount of sludge to be treated was about 500 kg/batch. A Cockcroft-Walton type of electron accelerator and a machine to make thin layer of sludge were used for sludge disinfection. The composting plant consisted of a mixer, a granulating machine, a fermenter with three screw-type mixing blades, and a conveyer system. Efficient composting could be realized also by the pilot plant, by controlling fermentation temperature in the optimum range, by controlling air flow ra

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11

Amani, Leili, Fatemeh Fadaei, Ardakani Mohammadreza Shams, Ardakani Mehran Mirabzadeh, and Laila Shirbeigi. "Treatment of Diabetic Foot Ulcer (DFU) with Pharmaceutical Product using Hirudo orientalis: A Case Report." Journal of Advances in Medical and Biomedical Research 28, no. 129 (2020): 225–29. https://doi.org/10.30699/jambs.28.129.225.

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Every 30 seconds, one lower limb amputation due to diabetes is performed in the world. This study was conducted on a 64-year-old woman with a diabetic foot on her left leg [Sci Rew1] . The patient had pain with a visual analog scale (VAS) score of 80 mm on 100 mm. This study aimed to evaluate the effect of a product derived from leeches in the treatment of DFUs. Wound grade 1 according to Wagner’s classification system was covered with leech cream. A decoction of <em>Hirudo orientalis</em> was prepared by lyophilizing leeches at -80°C, the proteins containing biologica

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12

Kaziev, U. K., U. S. Musaev, A. S. Imankulova, and D. S. Miklukhin. "Ultrasonic cavitation for managing wounds in patients with purulent-necrotic complications of diabetic foot syndrome." Wounds and wound infections. The prof. B.M. Kostyuchenok journal 11, no. 2 (2024): 28–34. http://dx.doi.org/10.25199/2408-9613-2024-11-2-28-34.

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Objective: to evaluate the effectiveness of ultrasonic wound cavitation in patients with complicated forms of diabetic foot syndrome (DFS).Material and methods. A comparative analysis of outcomes after surgical treatment with ultrasonic cavitation in 90 patients having purulentnecrotic complications of diabetic foot syndrome, aged 16–75, was carried out. The first (studied) group included 30 patients who had ultrasonic cavitation sessions at the intra- and postoperative periods; the second (comparison) group included 60 patients who had no any ultrasonic cavitation sessions during their treatm

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13

Patil, Hemlata, Sateesh Kumar Vemula, Sagar Narala, et al. "Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation—Where Are We Now?" AAPS PharmSciTech 25, no. 2 (2024). http://dx.doi.org/10.1208/s12249-024-02749-2.

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AbstractHot-melt extrusion (HME) is a globally recognized, robust, effective technology that enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers an efficient continuous manufacturing process. The twin-screw extruder (TSE) offers an extremely resourceful customizable mixer that is used for continuous compounding and granulation by using different combinations of conveying elements, kneading elements (forward and reverse configuration), and distributive mixing elements. TSE is thus efficiently utilized for dry, wet, or melt granulation not only to manufact

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14

Saeed, Komal, Farid Ahmad Khan, Saad Bin Abdul Qudus, and Sundas Javed. "Autologous Fat Grafting – A Step Forward in Wound Management." International Journal of Lower Extremity Wounds, January 12, 2022, 153473462110733. http://dx.doi.org/10.1177/15347346211073388.

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Autologous fat grafting (AFG) is an emerging therapeutic option for wounds that are not ready for grafting. The regenerative potential of autologous fat lies in the adipose derived stem cells (ADSCs) contained within the stromal vascular fraction (SVF), which are capable of differentiating into multiple cell lineages. However to date, there has been no comprehensive evaluation of its efficacy in acute complicated wounds. This study aims to critically evaluate the efficacy and safety of AFG in cutaneous wound healing. Materials and Methods: This prospective, quasi experimental study was conduct

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15

Yashwanth, S., and T. Praneeth. "COMPARATIVE STUDY BETWEEN LIFT PROCEDURE VERSUS SETON PLACEMENT IN THE MANAGEMENT OF FISTULA IN ANO." GLOBAL JOURNAL FOR RESEARCH ANALYSIS, July 15, 2021, 61–64. http://dx.doi.org/10.36106/gjra/8001906.

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INTRODUCTION: A stula-in-ano, is a chronic abnormal communication, usually lined by granulation tissue, which runs outwards from the anorectal lumen. The standards of anal stula surgery are to obliterate the stula, prevent recurrence and maintain sphincter work. Ligation of Intersphincteric Fistula Tract (LIFT) is the most promising surgical technique based on secure closure of the internal opening and removal of the infected crypto glandular tissue through intersphincteric approach. AIMS: To compare the effectiveness of LIFT over SETON procedure based on Postoperative pain on day 1 and2, S

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