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Journal articles on the topic 'DTNA'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Tsoumpra, Maria K., Shun Sawatsubashi, Michihiro Imamura, et al. "Dystrobrevin alpha gene is a direct target of the vitamin D receptor in muscle." Journal of Molecular Endocrinology 64, no. 3 (2020): 195–208. http://dx.doi.org/10.1530/jme-19-0229.

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The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3), exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recognize vitamin D response elements (VDRE) and activate target genes. Upregulation of VDR in murine skeletal muscle cells occurs concomitantly with transcriptional regulation of key myogenic factors upon VD3 administration, reinforcing the notion that VD3 exerts beneficial effects on muscle. Herein we elucidated the regulatory role of VD3/VDR axis on

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Jiménez-Díaz, Manuel, and Viria Martínez-Monge. "Validación de la determinación de colinesterasa plasmática humana a 340 nM." REVISTA BIOMÉDICA 11, no. 2 (2000): 91–98. http://dx.doi.org/10.32776/revbiomed.v11i2.223.

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Introducción. Se presenta la validación de un método de monitoreo continuo para la cuantificación de colinesterasa plasmática empleando ácido 6-6-ditiodinicotínico (DTNA) como indicador. Materiales y métodos. Se emplearon muestras de plasma anticoagulado con EDTA. En este método la tiocolina liberada de la propioniltiocolina por la colinesterasa, reacciona con el DTNA liberando ácido tionicotínico y el aumento de absorbancia a 340 nM es proporcional a la actividad de la enzima. Resultados. Las precisiones día a día para muestras con valores de colinesterasa bajos y altos mostraron coeficiente

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Jiménez-Díaz, Manuel, and Viria Martínez-Monge. "Validación de la determinación de acetilcolinesterasa eritrocítica humana a 340 nm." REVISTA BIOMÉDICA 11, no. 3 (2000): 161–68. http://dx.doi.org/10.32776/revbiomed.v11i3.232.

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Introducción. Se presenta la validación de un método de monitoreo continuo para la cuantificación de acetilcolinesterasa eritrocítica humana (EC. 3.1.1.7) empleando ácido 6-6- ditiodinicotínico (DTNA) como indicador. Materiales y métodos. Se emplearon muestras de sangre total recogida con EDTA como anticoagulante. En este método la tiocolina liberada de la acetiltiocolina por la colinesterasa, reacciona con el DTNA liberando ácido tionicotínico y el aumento de absorbancia a 340 nM es proporcional a la actividad de la enzima. La interferencia debida a colinesterasa plasmática se elimina median

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Steen, Michelle S., Marvin E. Adams, Yan Tesch, and Stanley C. Froehner. "Amelioration of Muscular Dystrophy by Transgenic Expression of Niemann-Pick C1." Molecular Biology of the Cell 20, no. 1 (2009): 146–52. http://dx.doi.org/10.1091/mbc.e08-08-0811.

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Duchenne muscular dystrophy (DMD) and other types of muscular dystrophies are caused by the loss or alteration of different members of the dystrophin protein complex. Understanding the molecular mechanisms by which dystrophin-associated protein abnormalities contribute to the onset of muscular dystrophy may identify new therapeutic approaches to these human disorders. By examining gene expression alterations in mouse skeletal muscle lacking α-dystrobrevin (Dtna−/−), we identified a highly significant reduction of the cholesterol trafficking protein, Niemann-Pick C1 (NPC1). Mutations in NPC1 ca

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Restrepo Cortés, Beatriz, Ángela Liliana Londoño Franco, and Juan Farid Sánchez López. "Valores de colinesterasa plasmática y eritrocitaria con ácido 6-6‘-ditiodinicotínico (DTNA) como indicador." Revista Colombiana de Química 46, no. 1 (2017): 13. http://dx.doi.org/10.15446/rev.colomb.quim.v46n1.62849.

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Se realizó un estudio descriptivo transversal empleando ácido 6-6‘-ditiodinicotínico (DTNA) como indicador para calcular los valores de la actividad de colinesterasa plasmática (AchP) y eritrocitaria (AchE) humana y estandarizarlos para ser utilizados como indicadores de riesgo laboral por exposición a organofosforados y carbamatos en la población de la zona cafetera de Colombia. Se eligió esta técnica pues es una alternativa precisa, sencilla y económica: con pocos interferentes permite analizar AchP y AchE, no se tiene que corregir con hemoglobina; el DTNA es estable congelado o refrigerado

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Nascimento, A., C. Bruels, A. Codina, et al. "FP.36 Genetic variants in DTNA cause a mild dominantly inherited muscular dystrophy." Neuromuscular Disorders 32 (October 2022): S113. http://dx.doi.org/10.1016/j.nmd.2022.07.296.

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Martinez-Gomez, Estrella, Alvaro Gallego-Martinez, Pablo Roman-Naranjo, and Jose A. Lopez-Escamez. "Clinical and molecular genetics of Meniere disease." Medizinische Genetik 32, no. 2 (2020): 141–48. http://dx.doi.org/10.1515/medgen-2020-2019.

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Abstract Meniere disease (MD) represents a heterogeneous group of relatively rare disorders of the inner ear that causes vertigo attacks, fluctuating sensorineural hearing loss (SNHL) involving low and medium frequencies, tinnitus, and aural fullness. MD has been attributed to an accumulation of endolymph in the cochlear duct. The diagnosis of MD is based on the phenomenological association of clinical symptoms including SNHL during the vertigo attacks. At least two mechanisms are involved in MD: (a) a pro-inflammatory immune response mediated by interleukin-1 beta (IL-1β), tumor necrosis fact

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Requena, T., S. Cabrera, C. Martin-Sierra, S. D. Price, A. Lysakowski, and J. A. Lopez-Escamez. "Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere's disease." Human Molecular Genetics 24, no. 4 (2014): 1119–26. http://dx.doi.org/10.1093/hmg/ddu524.

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Hu, Zhi-Gao, Shun Zhang, Yu-Bing Chen та ін. "DTNA promotes HBV-induced hepatocellular carcinoma progression by activating STAT3 and regulating TGFβ1 and P53 signaling". Life Sciences 258 (жовтень 2020): 118029. http://dx.doi.org/10.1016/j.lfs.2020.118029.

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Nilda, Espínola-Zavaleta 1. 4. ME Soto 2. Eulo Lupi-Herrera 1. Paola Romano 1. Verónica Guarner-Lans 3. Claudia Huesca-Gómez 3. Ricardo Gamboa*3. "THE POLYMORPHISMS LDB3 (rs45618633), TAZ (rs104894941), LMNA (rs28928903), DTNA (rs7243528) AND TNNT2 G/T (rs2365652) AND ITS ASSOCIATION WITH NON-COMPACTED CARDIOMYOPATHY IN MEXICAN MESTIZO FAMILY." Indian Journal of Medical Research and Pharmaceutical Sciences 4, no. 12 (2017): 13–23. https://doi.org/10.5281/zenodo.1095889.

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<strong>Introduc</strong><strong>tion:</strong> Noncompacted cardiomyopathy (NCC) has been attributed to the mutation in multiple genes leading to interruption in the endomyocardial compaction process. <strong>Objective:</strong> The objective of this work was to identify gene variants that participated in the development of NCC in a Mexican mestizo family. <strong>Material and methods</strong>: A total of 36 (85.7%) individuals from a family of 42 members were studied. All patients underwent clinical history, transthoracic echocardiography and the polymorphisms: <em>LDB3, TAZ, LMNA,

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Chen, Chih-Ping, Chih-Heng Hsieh, Schu-Rern Chern, et al. "Prenatal diagnosis and molecular cytogenetic characterization of an interstitial deletion of 18q12.1-q12.3 encompassing DTNA , CELF4 and SETBP1." Taiwanese Journal of Obstetrics and Gynecology 56, no. 6 (2017): 847–51. http://dx.doi.org/10.1016/j.tjog.2017.10.027.

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Escalera-Balsera, Alba, Pablo Roman-Naranjo, and Jose Antonio Lopez-Escamez. "Systematic Review of Sequencing Studies and Gene Expression Profiling in Familial Meniere Disease." Genes 11, no. 12 (2020): 1414. http://dx.doi.org/10.3390/genes11121414.

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Familial Meniere Disease (FMD) is a rare inner ear disorder characterized by episodic vertigo associated with sensorineural hearing loss, tinnitus and/or aural fullness. We conducted a systematic review to find sequencing studies segregating rare variants in FMD to obtain evidence to support candidate genes for MD. After evaluating the quality of the retrieved records, eight studies were selected to carry out a quantitative synthesis. These articles described 20 single nucleotide variants (SNVs) in 11 genes (FAM136A, DTNA, PRKCB, COCH, DPT, SEMA3D, STRC, HMX2, TMEM55B, OTOG and LSAMP), most of

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Arda, Hany Dwi, Muhammad Iqbal Syauqi, and Jarnuzi Gunlazuardi. "Preliminary Studi of Dye-Sensitized Solar Cell Photoelectrochemical for CO2 Conversion to Methanol Using CuO-modified Dark TiO2 Nanotubes Array as Cathode." Molekul 19, no. 3 (2024): 541. https://doi.org/10.20884/1.jm.2024.19.3.11162.

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The increased atmospheric carbon dioxide (CO2) levels can lead to climate change and adversely affect human health. Therefore, it is necessary to develop a method to capture CO2 and convert it into a more valuable substance, such as methanol. In this study, we established a tandem system involving dye-sensitized solar cells and photoelectrochemical (DSSC-PEC), which included the PEC zone using CuO/dark TiO2 nanotube array (CuO/dTNA) as the dark cathode where CO2 reduction takes place, and Co-Pi/blue TiO2 nanotube array (Co-Pi/bTNA) as the counter photoanode. For the DSSC zone, N719/TNA was use

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Cao, Qing, Yang Shen, Xin Liu, et al. "Phenotype and Functional Analyses in a Transgenic Mouse Model of Left Ventricular Noncompaction Caused by a DTNA Mutation." International Heart Journal 58, no. 6 (2017): 939–47. http://dx.doi.org/10.1536/ihj.16-019.

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Petrovici, Alina, Jose Luis Cueto, Valentin Nedeff, et al. "Dynamic Evaluation of Traffic Noise through Standard and Multifractal Models." Symmetry 12, no. 11 (2020): 1857. http://dx.doi.org/10.3390/sym12111857.

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Traffic microsimulation models use the movement of individual driver-vehicle-units (DVUs) and their interactions, which allows a detailed estimation of the traffic noise using Common Noise Assessment Methods (CNOSSOS). The Dynamic Traffic Noise Assessment (DTNA) methodology is applied to real traffic situations, then compared to on-field noise levels from measurement campaigns. This makes it possible to determine the influence of certain local traffic factors on the evaluation of noise. The pattern of distribution of vehicles along the avenue is related to the logic of traffic light control. T

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Komissarova, S. M., N. M. Rineiska, N. N. Chakova, and S. S. Niyazova. "Overlapping Phenotype: Left Ventricular non-Compaction and Hypertrophic Cardiomyopathy." Kardiologiia 60, no. 4 (2020): 137–45. http://dx.doi.org/10.18087/cardio.2020.4.n728.

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Aim To study the clinical course of the mixed phenotype (hypertrophic cardiomyopathy, HCMP, and left ventricular noncompaction, LVNC); to determine its genetic causes; and to evaluate incidence of cardiovascular complications (CVC) during the follow-up period.Material and methods In screening of 286 patients with HCMP, 8 of them (2.8 %; median age, 41.5 years; 4 men and 4 women) from unrelated families were found to have the mixed phenotype (combination of HCMP and LVNC). For their 10 first-degree relatives, the most frequent phenotype was HCMP without LVNC; however, both isolated LVNC and the

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Neubauer, Jacqueline, Shouyu Wang, Giancarlo Russo, and Cordula Haas. "Re-evaluation of single nucleotide variants and identification of structural variants in a cohort of 45 sudden unexplained death cases." International Journal of Legal Medicine 135, no. 4 (2021): 1341–49. http://dx.doi.org/10.1007/s00414-021-02580-5.

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AbstractSudden unexplained death (SUD) takes up a considerable part in overall sudden death cases, especially in adolescents and young adults. During the past decade, many channelopathy- and cardiomyopathy-associated single nucleotide variants (SNVs) have been identified in SUD studies by means of postmortem molecular autopsy, yet the number of cases that remain inconclusive is still high. Recent studies had suggested that structural variants (SVs) might play an important role in SUD, but there is no consensus on the impact of SVs on inherited cardiac diseases. In this study, we searched for p

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Kechin, Andrey, Viktoriya Borobova, Alexander Kel, Anatoliy Ivanov, and Maxim Filipenko. "ErbB4 Is a Potential Key Regulator of the Pathways Activated by NTRK-Fusions in Thyroid Cancer." Applied Sciences 12, no. 5 (2022): 2506. http://dx.doi.org/10.3390/app12052506.

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NTRK gene fusions are drivers of tumorigenesis events that specific Trk-inhibitors can target. Current knowledge of the downstream pathways activated has been previously limited to the pathways of regulator proteins phosphorylated directly by Trk receptors. Here, we aimed to detect genes whose expression is increased in response to the activation of these pathways. We identified and analyzed differentially expressed genes in thyroid cancer samples with NTRK1 or NTRK3 gene fusions, and without any NTRK fusions, versus normal thyroid gland tissues, using data from the Cancer Genome Atlas, the DE

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Lopez-Escamez, Jose Antonio, Angel Batuecas-Caletrio, and Alexandre Bisdorff. "Towards personalized medicine in Ménière’s disease." F1000Research 7 (August 15, 2018): 1295. http://dx.doi.org/10.12688/f1000research.14417.1.

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Ménière’s disease (MD) represents a heterogeneous group of relatively rare disorders with three core symptoms: episodic vertigo, tinnitus, and sensorineural hearing loss involving 125 to 2,000 Hz frequencies. The majority of cases are considered sporadic, although familial aggregation has been recognized in European and Korean populations, and the search for familial MD genes has been elusive until the last few years. Detailed phenotyping and cluster analyses have found several clinical predictors for different subgroups of patients, which may indicate different mechanisms, including genetic a

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Lee, Young Y., Kwang-Sung Ahn, Sung-Soo Yoon, Jung H. Choi, Byoung B. Park, and Byoung K. Kim. "FLT3 Is Up-Regulated in Blast Crisis of Chronic Myeloid Leukemia and Combination of Small Interference RNA of FLT3 and Gleevec (STI571) Synergistically Induces the Apoptosis in K562 Cells." Blood 110, no. 11 (2007): 4532. http://dx.doi.org/10.1182/blood.v110.11.4532.4532.

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Abstract To identify a gene signature for prognostic markers at transition from chronic phase to blast crisis of chronic myeloid leukemia (CML), we have applied Affymetrix Genechips of 22,000 transcripts to analyze total RNA of CML cells from 12 patients with chronic phase and 12 patients with blast crisis. Data analysis using GeneSpring 6.0 generated a list of 143 differentially expressed genes. A total of 89 genes were up-regulated and 54 genes were down-regulated in blast crisis of CML, and vice versa in chronic phase of CML. Array data for 32 genes was validated using quantitative realtime

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Alshabi, Ali Mohamed, Basavaraj Vastrad, Ibrahim Ahmed Shaikh, and Chanabasayya Vastrad. "Identification of Crucial Candidate Genes and Pathways in Glioblastoma Multiform by Bioinformatics Analysis." Biomolecules 9, no. 5 (2019): 201. http://dx.doi.org/10.3390/biom9050201.

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The present study aimed to investigate the molecular mechanisms underlying glioblastoma multiform (GBM) and its biomarkers. The differentially expressed genes (DEGs) were diagnosed using the limma software package. The ToppGene (ToppFun) was used to perform pathway and Gene Ontology (GO) enrichment analysis of the DEGs. Protein-protein interaction (PPI) networks, extracted modules, miRNA-target genes regulatory network and TF-target genes regulatory network were used to obtain insight into the actions of DEGs. Survival analysis for DEGs was carried out. A total of 590 DEGs, including 243 up re

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Ji, M. R., D. M. Jang, Y. S. Lee, H. T. Cheong, B. K. Yang, and C. K. Park. "169 CHANGES OF PROTEIN PROFILES DURING FOLLICLE DEVELOPMENT AND IN VITRO OOCYTE MATURATION IN THE PIG." Reproduction, Fertility and Development 23, no. 1 (2011): 187. http://dx.doi.org/10.1071/rdv23n1ab169.

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When fully grown oocytes are removed from their follicles, they can resume meiosis and mature spontaneously under in vitro conditions. However, nuclear maturation under in vitro conditions is not accompanied by complete cytoplasmic maturation, which is essential for successful fertilization and the initiation of zygotic development. In the first study, to investigate protein patterns during oocyte maturation in vitro, immature oocytes (germinal vesicle stage; GV stage) as control and oocytes matured (M-II phase) in vitro were analysed. The porcine oocytes in the GV stage were put in culture wi

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Chen, Kang, and Haiying Shen. "DTN-FLOW: Inter-Landmark Data Flow for High-Throughput Routing in DTNs." IEEE/ACM Transactions on Networking 23, no. 1 (2015): 212–26. http://dx.doi.org/10.1109/tnet.2013.2296751.

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Zhang, Zhenjing, Maode Ma, and Zhigang Jin. "CCS-DTN: Clustering and Network Coding-Based Efficient Routing in Social DTNs." Sensors 15, no. 1 (2014): 285–303. http://dx.doi.org/10.3390/s150100285.

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Curtiss, Frederic R. "Direct-to-Patient Advertising (DTPA) and Direct-to-Consumer Advertising (DTCA) of Prescription Drugs." Journal of Managed Care Pharmacy 8, no. 6 (2002): 521–22. http://dx.doi.org/10.18553/jmcp.2002.8.6.521.

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Velev, Valentin, Anton Popov, Lyubomira Veleva, and Nikola Todorov. "THERMAL RESISTANCE OF POLYETHYLENE TEREPHTHALATE FIBRES." Journal scientific and applied research 5, no. 1 (2014): 162–72. http://dx.doi.org/10.46687/jsar.v5i1.125.

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The thermal resistance of isotropic and orientated poly(ethylene terephthalate) (PET) samples was studied. Part of the oriented PET specimens was heat mechanically modified under different conditions. Using differential thermal analysis (DTA), thermal gravimetric analysis (TGA) and differential thermal gravimetric analysis (DTGA) it was investigated the influence of the forming methods and the modes of heat mechanically treatment on the relative samples thermal oxidation stability. It was determined basic thermodynamic and kinetic parameters, as well as the limiting mechanisms of the basic des

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Velev, Valentin. "THERMAL RESISTANCE OF POLYETHYLENE TEREPHTHALATE FIBRES." Journal Scientific and Applied Research 6, no. 1 (2014): 155–65. http://dx.doi.org/10.46687/jsar.v6i1.153.

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The thermal resistance of isotropic and orientated poly(ethylene terephthalate) (PET) samples was studied. Part of the oriented PET specimens was heat mechanically modified under different conditions. Using differential thermal analysis (DTA), thermal gravimetric analysis (TGA) and differential thermal gravimetric analysis (DTGA) it was investigated the influence of the forming methods and the modes of heat mechanically treatment on the relative samples thermal oxidation stability. It was determined basic thermodynamic and kinetic parameters, as well as the limiting mechanisms of the basic des

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Wang, Weitao, Yuebin Bai, Peng Feng, Jun Huang, Mo Sha, and Jianpei Tantai. "DTN-Balance: A Forwarding-Capacity and Forwarding-Queue Aware Routing for Self-organizing DTNs." Wireless Personal Communications 118, no. 1 (2021): 575–98. http://dx.doi.org/10.1007/s11277-020-08033-3.

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Kumar, Manoj, P. L. Sah, M. G. H. Zaidi, and Anupam Srivastav. "Thermal Characterization of Low Grade Wood Polyacylonitrile Composite." Advanced Materials Research 214 (February 2011): 392–96. http://dx.doi.org/10.4028/www.scientific.net/amr.214.392.

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A series of wood polyacrylonitrile (PAN) composites (WPCs) were synthesized through impregnation polymerization of Eucalyptus wood (Eucalyptus Grandies) by acrylonitrile (AN) in methanol (20-60% v/v) in the presence of benzoyl peroxide (1.0% w/v) in benzene medium at 70 ±10C. This resulted in corresponding WPCs with polyacrylonitrile (PAN) loading in the range of 15.5-20%. Loading of PAN into wood, as ascertained through TGA, DTGA and DTA and supported by Fourier Transform Infrared Spectroscopy (FTIR) as well as Scanning Electron Microscopy (SEM) was found to increase the resistance against th

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Di Mauro, Chiara, Aratz Genua, and Alice Mija. "Kinetical Study, Thermo-Mechanical Characteristics and Recyclability of Epoxidized Camelina Oil Cured with Antagonist Structure (Aliphatic/Aromatic) or Functionality (Acid/Amine) Hardeners." Polymers 13, no. 15 (2021): 2503. http://dx.doi.org/10.3390/polym13152503.

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In an attempt to prepare sustainable epoxy thermosets, this study introduces for the first time the idea to use antagonist structures (aromatic/aliphatic) or functionalities (acid/amine) as hardeners to produce reprocessable resins based on epoxidized camelina oil (ECMO). Two kinds of mixtures were tested: one combines aromatic/aliphatic dicarboxylic acids: 2,2′-dithiodibenzoic acid (DTBA) and 3,3′-dithiodipropionic acid (DTDA); another is the combination of two aromatic structures with acid/amine functionality: DTBA and 4-aminophenyl disulfide (4-AFD). DSC and FT-IR analyses were used as meth

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Couchet, J. M., J. Azéma, C. Galaup, and C. Picard. "Eu(III) and Tb(III) luminescent lanthanide systems derived from DTPA-bisamide and DTTA-based ligands incorporating bipyridine antenna." Journal of Luminescence 131, no. 12 (2011): 2735–45. http://dx.doi.org/10.1016/j.jlumin.2011.06.052.

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Couchet, Jean-Marc, Joëlle Azéma, Pierre Tisnès, and Claude Picard. "Sensitization of europium(III) luminescence in bis(bipyridine) DTPA and DTTA-based ligands: effect of the deletion of amide groups." Inorganic Chemistry Communications 6, no. 7 (2003): 978–81. http://dx.doi.org/10.1016/s1387-7003(03)00162-x.

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Quinn, Aidan D., Neil J. OʼHare, Fintan J. Wallis, and Graham F. Wilson. "Gd-DTPA." Journal of Computer Assisted Tomography 18, no. 4 (1994): 634–36. http://dx.doi.org/10.1097/00004728-199407000-00022.

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BARD, DAVID R., E. PHILLIP WRAIGHT, and C. GRAHAM KNIGHT. "BisMSH-DTPA." Annals of the New York Academy of Sciences 680, no. 1 The Melanotro (1993): 451–53. http://dx.doi.org/10.1111/j.1749-6632.1993.tb19705.x.

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Gries, H. "GADOLINIUM-DTPA." Drugs of the Future 13, no. 3 (1988): 227. http://dx.doi.org/10.1358/dof.1988.013.03.62411.

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Romero Toledo, Rafael, Víctor Ruiz Santoyo, Cristina D. Moncada Sánchez, and Merced Martínes Rosales. "Effect of aluminum precursor on physicochemical properties of Al2O3 by hydrolysis/precipitation method." Nova Scientia 10, no. 20 (2018): 83–99. http://dx.doi.org/10.21640/ns.v10i20.1217.

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This study reports the synthesis of mesoporous nano-fibrillar alumina prepared by hydrolysis-precipitation route from aqueous solution of aluminum sulfate analytical reagent (AR) compared to aluminum sulfate technical grade (TG) of low purity under similar conditions using ammonia as the precipitating agent. The phisicochemical properties of these samples was studied with the assistance of characterization techniques such as Thermogravimetric and differential thermal analysis (TG/DTGA–DTA), X-ray diffraction (XRD), N2 adsorption-desorption isotherms, Fourier transform infrared (FTIR) spectrosc

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Rattat, Dirk, Christelle Terwinghe, and Alfons Verbruggen. "Comparison of ‘classic’ 99mTc–DTPA, 99mTc(CO)3–DTPA and 99mTc(CO)2(NO)–DTPA." Tetrahedron 61, no. 40 (2005): 9563–68. http://dx.doi.org/10.1016/j.tet.2005.07.086.

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Preechavuthinant, Sathorn, William Willis, and Alberto Coustasse. "Trends and effects of pharmaceutical DTCA." International Journal of Pharmaceutical and Healthcare Marketing 12, no. 1 (2018): 61–70. http://dx.doi.org/10.1108/ijphm-04-2017-0019.

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Purpose The purpose of this paper is to investigate the current trend of pharmaceutical direct-to-consumer advertising (DTCA) in the USA and its effect to patients, physicians and drug utilization. The DTCA of pharmaceutical firms is defined as an attempt of pharmaceutical companies to advertise product directly to patients. Design/methodology/approach The methodology used is literature review complemented with a semi-structured interview. Findings Pharmaceutical DTCA showed a reduction in total spending, whereas the online channel experienced growth. DTCA affected the physician–patient relati

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Knight, Robert A., Kishor Karki, James R. Ewing, et al. "Estimating Blood and Brain Concentrations and Blood-to-Brain Influx by Magnetic Resonance Imaging with Step-Down Infusion of Gd-DTPA in Focal Transient Cerebral Ischemia and Confirmation by Quantitative Autoradiography with Gd-[14C]DTPA." Journal of Cerebral Blood Flow & Metabolism 29, no. 5 (2009): 1048–58. http://dx.doi.org/10.1038/jcbfm.2009.20.

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An intravenous step-down infusion procedure that maintained a constant gadolinium-diethylene-triaminepentaacetic acid (Gd-DTPA) blood concentration and magnetic resonance imaging (MRI) were used to localize and quantify the blood-brain barrier (BBB) opening in a rat model of transient cerebral ischemia ( n = 7). Blood-to-brain influx rate constant ( K i) values of Gd-DTPA from such regions were estimated using MRI-Patlak plots and compared with the K, values of Gd-[14C]DTPA, determined minutes later in the same rats with an identical step-down infusion, quantitative autoradiography (QAR), and

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Ye, Hai Qing, Jing Bo Liu, Jun Xiao Wei, Meng Lei Xu, and Yan Song Li. "Synthesis and Identification of Heavy Metal Lead Artificial Antigen." Advanced Materials Research 750-752 (August 2013): 1405–9. http://dx.doi.org/10.4028/www.scientific.net/amr.750-752.1405.

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Lead ions were coupled to protein carrier bovine serum albumin (BSA) and keyhole limpet hemocyanin (KLH) respectively. Diethylene Triamine Pentacetate Acid (DTPA) was used as bifunctional chelator. Pb-DTPA-Carrier protein, DTPA-Carrier protein and carrier protein were detected qualitatively with ICP-MS, UV spectrophotometer and electrophoresis. It turns out that the Pb-DTPA-Carrier protein contains certain concentration of heavy metal ion, the maximum ultraviolet absorption peak value of Pb-DTPA-Carrier protein significantly higher than that of DTPA-Carrier protein and carrier protein, and the

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Atallah-Yunes, Suheil Albert, and Myat Han Soe. "Drug-Induced Thrombotic Microangiopathy due to Cumulative Toxicity of Ixazomib." Case Reports in Hematology 2018 (July 3, 2018): 1–5. http://dx.doi.org/10.1155/2018/7063145.

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Drug-induced thrombotic microangiopathies (DTMAs) are increasingly being recognized as an important category of thrombotic microangiopathies (TMAs). Cancer therapeutic agents including proteasome inhibitors (PIs) are among the most common medications reported to cause DTMA. PIs could cause DTMA either by an immune mechanism or dose-dependent/cumulative toxicity. Eleven cases of DTMA have been reported with bortezomib and carfilzomib. To the best of our knowledge, only one case of DTMA has been reported with ixazomib due to an immune-mediated mechanism. Here, we report the first case of ixazomi

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Meek, C. "Europe reconsidering DTCA." Canadian Medical Association Journal 176, no. 10 (2007): 1405. http://dx.doi.org/10.1503/cmaj.070483.

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Guinnessy, Paul. "Younger Leaves DTRA." Physics Today 57, no. 7 (2004): 31. http://dx.doi.org/10.1063/1.4796609.

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Kawamura, Yasutaka. "Gd-DTPA-DeA." Academic Radiology 9, no. 1 (2002): S102—S103. http://dx.doi.org/10.1016/s1076-6332(03)80410-5.

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Bard, D. R. "MonoNDP-MSH-DTPA." Nuclear Medicine Communications 16, no. 4 (1995): 245. http://dx.doi.org/10.1097/00006231-199504000-00128.

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Barbarick, K. A., and S. M. Workman. "Ammonium Bicarbonate-DTPA and DTPA Extractions of Sludge-amended Soils." Journal of Environmental Quality 16, no. 2 (1987): 125–30. http://dx.doi.org/10.2134/jeq1987.00472425001600020006x.

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Lin, Min-Ying, Hsin-Hua Hsieh, Jyh-Cheng Chen, et al. "Brachytherapy Approach Using 177Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model." Pharmaceutics 13, no. 11 (2021): 1903. http://dx.doi.org/10.3390/pharmaceutics13111903.

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Brachytherapy can provide sufficient doses to head and neck squamous cell carcinoma (HNSCC) with minimal damage to nearby normal tissues. In this study, the β−-emitter 177Lu was conjugated to DTPA-polyethylene glycol (PEG) decorated gold nanostars (177Lu-DTPA-pAuNS) used in surface-enhanced Raman scattering and photothermal therapy (PTT). The accumulation and therapeutic efficacy of 177Lu-DTPA-pAuNS were compared with those of 177Lu-DTPA on an orthotopic HNSCC tumor model. The SPECT/CT imaging and biodistribution studies showed that 177Lu-DTPA-pAuNS can be accumulated in the tumor up to 15 day

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O'Brodovich, H., G. Coates, J. Kay, and D. Muysson. "Simultaneous measurement of lung clearance rates for Tc- and In-DTPA in normal and damaged lungs." Journal of Applied Physiology 66, no. 5 (1989): 2293–97. http://dx.doi.org/10.1152/jappl.1989.66.5.2293.

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We investigated the relative clearance rates for 99mTc-labeled diethylenetriamine-pentaacetate (Tc-DTPA) and 113mIn-labeled DTPA (In-DTPA) when they were inhaled and deposited together within the lungs of same animal. Submicronic aerosols containing Tc-DTPA and In-DTPA were simultaneously generated by different nebulizers and collected within the same anesthetic bag. The combined aerosols were insufflated into piglets. Clearances for both compounds were measured simultaneously in normal lungs and when the lungs were damaged by intravenous oleic acid or by a presumed oxidant agent, intravenous

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SATO, I., N. MATSUSAKA, T. SUZUKI, H. KOBAYASHI, K. SERA, and S. FUTATSUGAWA. "ESSENTIAL METAL CONTENTS IN THE LIVER OF DTPA-TREATED PREGNANT MICE AND THEIR FETUSES." International Journal of PIXE 07, no. 01n02 (1997): 25–29. http://dx.doi.org/10.1142/s0129083597000047.

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Ca -DTPA or Zn -DTPA was injected subcutaneously to pregnant mice once a day for 5 consecutive days from the 13th day to the 17th day of gestation. Maternal and fetal livers were collected 20 hours after the final injection of DTPA, and essential metal contents in the liver samples were determined by PIXE. Both Ca -DTPA and Zn -DTPA don't affect any essential metals in the maternal liver, but Ca -DTPA decreases copper and zinc contents in the fetal liver to 2/3 and 1/2 of the control values, respectively. Although Zn -DTPA does not affect fetal zinc content, it decreases that of copper. It cou

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Ginger, R. S., L. Drury, C. Baader, N. V. Zhukovskaya, and J. G. Williams. "A novel Dictyostelium cell surface protein important for both cell adhesion and cell sorting." Development 125, no. 17 (1998): 3343–52. http://dx.doi.org/10.1242/dev.125.17.3343.

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A mutant of Dictyostelium that is aberrant in the process of tip formation (dtfA-: defective in tip formation A) has been isolated by gene tagging. The dtfA gene is predicted to encode a protein of 163 kDa. There are no extensive sequence homologies between DTFA and previously identified proteins, but four short N-terminal sequence motifs show partial homology to repeats found in mammalian mucins. Immunofluorescence reveals a lattice-like arrangement of DTFA protein at the cell surface. When developing on a bacterial lawn, cells of the mutant strain (dtfA- cells) aggregate to form tight mounds

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