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Journal articles on the topic 'Du er ping kuang'

Author: Grafiati

Published: 26 July 2024

Last updated: 31 July 2025

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1

Gregorič, Matjaž, Kuang-Ping Yu, Winny Rojas Velez, and Jessica E. Garb. "Caerostris (Araneidae: Araneae) cryptic diversity highlights the need for taxonomic expertise in the genomic era." European Journal of Taxonomy 989 (April 24, 2025): 1–23. https://doi.org/10.5852/ejt.2025.989.2877.

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Gregorič, Matjaž, Yu, Kuang-Ping, Velez, Winny Rojas, Garb, Jessica E. (2025): Caerostris (Araneidae: Araneae) cryptic diversity highlights the need for taxonomic expertise in the genomic era. European Journal of Taxonomy 989: 1-23, DOI: 10.5852/ejt.2025.989.2877, URL: https://europeanjournaloftaxonomy.eu/index.php/ejt/article/download/2877/13061

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Tian, Jing, Ling Pen, Jian-Cheng Zhou, et al. "Phyllagathis guidongensis (Melastomataceae), a new species from Hunan, China." Phytotaxa 263, no. 1 (2016): 58–62. https://doi.org/10.11646/phytotaxa.263.1.6.

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Tian, Jing, Pen, Ling, Zhou, Jian-Cheng, Tian, Xue-Hui, Yi, Ren-Yuan, Liu, Lei, Cai, Xiu-Zhen, Kuang, Ren-Ping, Liu, Ke-Ming (2016): Phyllagathis guidongensis (Melastomataceae), a new species from Hunan, China. Phytotaxa 263 (1): 58-62, DOI: 10.11646/phytotaxa.263.1.6, URL: http://dx.doi.org/10.11646/phytotaxa.263.1.6

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Yu, Kuang-Ping, Ying-Yuan Lo, Wen-Chun Huang, Yun Hsiao, and Tzung-Su Ding. "Redescription of a wall crab spider species from Taiwan: Siamspinops formosensis (Kayashima, 1943) comb. nov., with the first description of males and taxonomic notes (Araneae: Selenopidae)." Zootaxa 4543, no. 4 (2019): 590–94. https://doi.org/10.11646/zootaxa.4543.4.8.

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Yu, Kuang-Ping, Lo, Ying-Yuan, Huang, Wen-Chun, Hsiao, Yun, Ding, Tzung-Su (2019): Redescription of a wall crab spider species from Taiwan: Siamspinops formosensis (Kayashima, 1943) comb. nov., with the first description of males and taxonomic notes (Araneae: Selenopidae). Zootaxa 4543 (4): 590-594, DOI: 10.11646/zootaxa.4543.4.8

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Yuan, Hsiao-Wei, D. Brent Burt, Lee-Ping Wang, et al. "Colony site choice of blue-tailed bee-eaters: influences of soil, vegetation, and water quality." Journal of Natural History 40, no. 7-8 (2006): 485–93. https://doi.org/10.1080/00222930600681043.

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Yuan, Hsiao-Wei, Burt, D. Brent, Wang, Lee-Ping, Chang, Wen-Lian, Wang, Ming-Kuang, Chiou, Chyi-Rong, Ding, Tzung-Su (2006): Colony site choice of blue-tailed bee-eaters: influences of soil, vegetation, and water quality. Journal of Natural History 40 (7-8): 485-493, DOI: 10.1080/00222930600681043, URL: http://dx.doi.org/10.1080/00222930600681043

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Chi, Ya-Hui, Chun-Ping Chang, Teng-Kuang Yeh, et al. "Abstract 5806: Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus." Cancer Research 84, no. 6_Supplement (2024): 5806. http://dx.doi.org/10.1158/1538-7445.am2024-5806.

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Abstract Aurora kinase inhibitors such as alisertib can destabilize MYC-family oncoproteins and have demonstrated compelling anti-tumor efficacy. In this study, we report 6K465, a novel pyrimidine-based Aurora A (AURKA) inhibitor that reduces levels of c-MYC and N-MYC oncoproteins more potently than alisertib. In an analysis of the antiproliferative effect of 6K465, the sensitivities of small cell lung cancer (SCLC) and breast cancer (BC) cell lines to 6K465 were strongly associated with the protein levels of c-MYC and/or N-MYC. We also report DBPR728, an acyl-based prodrug of 6K465 bearing fe

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Cai, Hong-Xia, Jing Che, Jun-Feng Pang, Er-Mi Zhao, and Ya-Ping Zhang. "Paraphyly of Chinese Amolops (Anura, Ranidae) and phylogenetic position of the rare Chinese frog, Amolops tormotus." Zootaxa 1531, no. 1 (2007): 49–55. https://doi.org/10.11646/zootaxa.1531.1.4.

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Cai, Hong-Xia, Che, Jing, Pang, Jun-Feng, Zhao, Er-Mi, Zhang, Ya-Ping (2007): Paraphyly of Chinese Amolops (Anura, Ranidae) and phylogenetic position of the rare Chinese frog, Amolops tormotus. Zootaxa 1531 (1): 49-55, DOI: 10.11646/zootaxa.1531.1.4, URL: https://biotaxa.org/Zootaxa/article/view/zootaxa.1531.1.4

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Chi, Ya-Hui, Chun-Ping Chang, Teng-Kuang Yeh, et al. "Abstract 523: Targeting myc-amplified cancers with a novel prodrug inhibiting aurora A kinase." Cancer Research 83, no. 7_Supplement (2023): 523. http://dx.doi.org/10.1158/1538-7445.am2023-523.

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Abstract Upregulation of Aurora kinases has been associated with increased tumor progression, and thus they are appealing targets for the development of anti-cancer therapies. In addition to have a critical role in cell cycle regulation, Aurora kinases have been shown to stabilize MYC-family oncoproteins for the maintenance of malignancy. Aurora kinase inhibitors such as Alisertib has demonstrated compelling anti-tumor efficacies; however, the reported side effects including serious haematological disturbances have limited its risk-benefit ratio in clinical use. In this study we discovered a n

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Ball, Alexander, Yung Lin Hsieh, Chun Kai Huang, et al. "Abstract 1325: Novel recombinant rabbit monoclonal antibodies for cancer biology research." Cancer Research 83, no. 7_Supplement (2023): 1325. http://dx.doi.org/10.1158/1538-7445.am2023-1325.

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Abstract Recombinant monoclonal antibodies (rAbs) are superior tools for cancer biology research as they offer distinct advantages over standard polyclonal and hybridoma-generated monoclonal antibody reagents. Recombinant technology produces antibodies that can be defined at the primary sequence level and are characterized by consistent performance and supply. These rAb features are in stark contrast to traditional polyclonal and hybridoma-generated monoclonal antibodies, whose lack of dependability has been widely documented as a primary reason for data irreproducibility plaguing biomedical r

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Li, Jia-Tang, Jun Liu, Yue-Ying Chen, et al. "Molecular phylogeny of treefrogs in the Rhacophorus dugritei species complex (Anura: Rhacophoridae), with descriptions of two new species." Zoological Journal of the Linnean Society 165, no. 1 (2012): 143–62. https://doi.org/10.1111/j.1096-3642.2011.00790.x.

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Li, Jia-Tang, Liu, Jun, Chen, Yue-Ying, Wu, Jia-Wei, Murphy, Robert W., Zhao, Er-Mi, Wang, Yue-Zhao, Zhang, Ya-Ping (2012): Molecular phylogeny of treefrogs in the Rhacophorus dugritei species complex (Anura: Rhacophoridae), with descriptions of two new species. Zoological Journal of the Linnean Society 165 (1): 143-162, DOI: 10.1111/j.1096-3642.2011.00790.x, URL: http://dx.doi.org/10.1111/j.1096-3642.2011.00790.x

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Li, Ning, Peng Jiang, Yuzhen Huang, et al. "Estrogen Receptor- And Progesterone Receptor-Positive Thresholds in Predicting the Recurrence of Early Low-Risk Endometrial Cancer." Clinical Medicine Insights: Oncology 16 (January 2022): 117955492211032. http://dx.doi.org/10.1177/11795549221103200.

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Background: Estrogen receptors (ER) and progesterone receptors (PR) have important prognostic value in endometrial cancer, but there is no recognized positive immunohistochemical threshold for predicting the recurrence of early low-risk endometrial cancer. The purpose of this study was to clarify the optimal positive thresholds of the immunohistochemical parameters the ER and PR in early low-risk endometrial cancer. Methods: A total of 332 patients with stage IA endometrial cancer were enrolled from the First Affiliated Hospital of Chongqing Medical University and People’s Hospital of Sha ping

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11

Bondebjerg, Ib. "Kritisk teori, æstetik og receptionsforskning." MedieKultur: Journal of media and communication research 4, no. 7 (1988): 26. http://dx.doi.org/10.7146/mediekultur.v4i7.765.

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Det er receptionsforskningens uomtvistelige fortjeneste, at den har sat focus på modtagernes oplevelser og vurderinger. Brugerne tages tilsyne- ladende alvorligt, i modsætning til den kritiske teori (Frankfurterskolen m.v.), der i debatten om receptionsforskningen er blevet beskyldt for at være formynderisk: Den tager stilling til æstetisk og indholdsmæssig kvalitet på brugernes vegne. I denne artikel forsøger Ib Bondebjerg at fastholde en del næsten glemte, men fundamentale nuancer (ikke mindst mht. tekstens status i forhold til oplevelsen) i både den kritiske teori, semiotikken og dele af re

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Hou, Sharon S. J., and Huang Wei-liang. "Huo-yu te feng-hung: Yu Kuang-chung tso-p'in p'ing-lun chi (Huo-yu de feng-huang)---(Yu Guang-zhong zuo pin ping-lun ji)." Chinese Literature: Essays, Articles, Reviews (CLEAR) 7, no. 1/2 (1985): 201. http://dx.doi.org/10.2307/495212.

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13

Zhang, Yuxing, Chundao Yang, Huijie Guo, et al. "Abstract 457: QLS1304, a highly potent and selective KAT6A/B inhibitor treating ER+HER2- breast cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 457. https://doi.org/10.1158/1538-7445.am2025-457.

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Abstract KAT6A and KAT6B, members of the MYST family of lysine acetyltransferases, are implicated in estrogen receptor-positive (ER+) breast cancer. KAT6A amplification occurs in about 10% of these patients, linking to overexpression and poorer outcomes. KAT6B is known to be functionally redundant with KAT6A in regulating levels of H3K23Ac, although its specific role in ER+HER2- breast cancer is not well understood. The simultaneous inhibition of KAT6A and KAT6B may lead to a more profound suppression of histone acetylation. Thus, the development of a dual inhibitor targeting KAT6A and KAT6B h

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14

Agger, Gunhild. "Reklamen som pastiche. Om Dansk Sygeplejeråds annoncekampagne efteråret 1986." MedieKultur: Journal of media and communication research 5, no. 10 (1989): 19. http://dx.doi.org/10.7146/mediekultur.v5i10.808.

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Der er flere og flere medieproducenter, der anser modtagerne for at besidde en vis tekstuel intelligens. Fra detektivpasticher som Dick Spanner og Batman over den konstant genreparodierende "Moon- lighting" (De heldige helte) til Poul og Nulles respektløse faktion "I sandhedens Tjeneste" leges der med betydningsdannelsen. Seerne/læserne indbydes til selv at spille ping-pong med billeder og tekst. Gunhild Agger analyserer her denne tendens, sådan som den kom- mer til udtryk inden for reklamen: Anker Jørgensen som James Bond, og kondomer til Prinsessen på Ærten! Mest indgående beskæftiger hun si

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Quroturohman, Denis. "PENETRATION TESTING DALAM FORENSIK DIGITAL PADA JARINGAN FAKULTAS TEKNIK UNIVERSITAS IBN KHALDUN BOGOR DENGAN PING OF DEATH." Jurnal Inovatif : Inovasi Teknologi Informasi dan Informatika 4, no. 2 (2021): 81. http://dx.doi.org/10.32832/inova-tif.v4i2.5812.

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<p><em>Network forensics is a computer security investigation to find sources of the attack s on the network by examining data log evidence, identifying, analyzing, and reconstructing the incidents. Types of attack s againist a computer or server on the network by spending resources that are owned by the computer until computer is not able to function properly, thus indirectly preventing other users to obtain access to network services that were attack ed is Distributed Denial of Service attack (DDoS). Network Forensics Research conducted in Research Laboratory of Information Engin

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Wang, Ping, Mariam Hassan, and Anjan Chatterjee. "1493. The Incremental Burden of Nontuberculous Mycobacterial Lung Disease (NTMLD) among Patients with chronic obstructive pulmonary disease (COPD): Hospitalizations and ER Visits among US Medicare Beneficiaries." Open Forum Infectious Diseases 7, Supplement_1 (2020): S748—S749. http://dx.doi.org/10.1093/ofid/ofaa439.1674.

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Abstract Background NTMLD is a rare mycobacterial infection characterized by worsening lung function and increased healthcare resource burden. Many patients with NTMLD have comorbid respiratory diseases such as COPD. Management of NTMLD in patients with COPD may not get adequate attention as clinical management of COPD is often prioritized. There is a lack of data quantifying the incremental burden of NTMLD among patients with COPD. We assessed the incremental burden of NTMLD in patients with comorbid COPD by comparing their healthcare resource utilization (HCRU), in terms of hospitalizations

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Chen, Mei-Kuang, Grace DeAlessandro, Tuyen Bui, and Khandan Keyomarsi. "Abstract PO2-04-14: Dual Inhibition of WEE1 and PKMYT1 Synergistically Overcomes CDK4/6 Inhibitor Resistance in Breast Cancer." Cancer Research 84, no. 9_Supplement (2024): PO2–04–14—PO2–04–14. http://dx.doi.org/10.1158/1538-7445.sabcs23-po2-04-14.

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Abstract Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) are approved for the treatment of advanced estrogen receptor-positive, HER2-negative (ER+ve) breast cancer when combined with endocrine therapy. However, the emergence of resistance to CDK4/6 inhibitors poses a significant clinical challenge. This study investigates the mechanisms underlying CDK4/6 inhibitor resistance and identifies a common occurrence of high replication stress in triple-negative breast cancer (TNBC) and CDK4/6 inhibitor-resistant ER+ve breast cancers. While ER+ve breast cancer patients have benefited from targeted th

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Lee, Pony Yu-Ling, Marvin A. Aberin, Chien-Chang Shen, et al. "Abstract 5953: Reshaping the tumor microenvironment: new application of tamoxifen in triple negative breast cancer immunomodulation." Cancer Research 83, no. 7_Supplement (2023): 5953. http://dx.doi.org/10.1158/1538-7445.am2023-5953.

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Abstract Tamoxifen is a widely known estrogen receptor (ER) modulator which has been employed in adjuvant treatment of ER+ breast cancer for over 30 years. Interestingly, clinical observations reveal that tamoxifen is capable of inducing regression of some tumors lacking ER expression whereas tamoxifen is also capable of increasing host resistance against cancer in an ER-independent mechanism. These findings suggest the immunomodulatory effects of tamoxifen may be ER-independent, but little is known about the underlying mechanism and the potential clinical implication. Recently, we identified

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Li, Hui-Ping, Qingyuan Zhang, Ruyan Zhang, Yaxin Liu, and Xianjun Hu. "Abstract PO4-04-01: Antitumor activity and safety of sacibertinib (Hemay022) in combination with endocrine therapy in patients with ER and HER2 both positive metastatic breast cancer: A phase Ib study." Cancer Research 84, no. 9_Supplement (2024): PO4–04–01—PO4–04–01. http://dx.doi.org/10.1158/1538-7445.sabcs23-po4-04-01.

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Abstract Abstract PURPOSE Sacibertinib (Hemay022) is a novel irreversible tyrosine kinase inhibitor (TKI) blocking epidermal growth factor receptor and human epidermal growth factor receptor 2 (HER2). This study aimed to explore the safety and efficacy of sacibertinib plus endocrine therapy in patients with estrogen receptor-positive ( PATIENTS AND METHODS Using a phase 1b 3+3 dose escalation and expansion study design, patients with ER+/HER2+ MBC were treated with sacibertinib (200mg-500mg daily) plus endocrine therapy including exemestane, letrozole, fulvestrant. The safety, pharmacokinetic

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ZHAO, XINGYU. "A Brief Analysis of China's Participation in Global Governance with Confucianism." Technium Business and Management 12 (June 25, 2025): 135–59. https://doi.org/10.47577/business.v12i.12967.

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This study employs Alexander Wendt’s constructivist theory as its analytical framework to examine the evolving role of Confucian culture in global governance and its shaping mechanisms in China’s diplomatic practices. Grounded in the proposition that “ideas construct interests and culture shapes identities,” it reveals how contemporary China creatively reinterprets core Confucian concepts—such as harmony in diversity (he er bu tong), the spirit of harmony (hexie jingshen), and the tianxia system—to construct a discourse system for global governance rooted in civilizational subjectivity. Confuc

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Jiang, Xiao-Ting, Mei-Kuang Chen, Jiwang Lee, et al. "Abstract 359: Rb loss-related DNA damage repair deficiency mediates the synthetically lethal effect of ATR/PKMYT1 co-inhibition in TNBC and CDK4/6i-resistant ER+ breast cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 359. https://doi.org/10.1158/1538-7445.am2025-359.

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Abstract Purpose: This study explores the therapeutic potential of dual ATR and PKMYT1 inhibition for treatment-resistant breast cancers, particularly triple-negative breast cancer (TNBC) and ER-positive breast cancer resistant to cyclin-dependent kinase 4/6 inhibitors (CDK4/6i). By investigating the synthetic lethality of ATR/PKMYT1 co-inhibition, we aimed to identify biomarkers predictive of treatment response, specifically examining Rb status and its effect on DNA damage repair mechanisms. Methods: The study tested the combination of ATR inhibitor (RP3500) and PKMYT1 inhibitor (RP6306) in T

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Li, Hui-Ping, Qingyuan Zhang, Ruyan Zhang, Yaxin Liu, Chang Liu, and Xianjun Hu. "Abstract PO2-27-11: Antitumor efficacy and safety of sacibertinib (Hemay022) in combination with endocrine therapy in patients with ER+ and HER2+ metastatic breast cancer: A phase Ib study." Cancer Research 84, no. 9_Supplement (2024): PO2–27–11—PO2–27–11. http://dx.doi.org/10.1158/1538-7445.sabcs23-po2-27-11.

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Abstract PURPOSE Sacibertinib (Hemay022) is a novel irreversible tyrosine kinase inhibitor (TKI) blocking epidermal growth factor receptor and human epidermal growth factor receptor 2 (HER2). This study aimed to explore the safety and efficacy of sacibertinib plus endocrine therapy in patients with estrogen receptor-positive (ER+) and HER2-positive (HER2+) &gt;metastatic breast cancer (MBC). PATIENTS AND METHODS Using a phase 1b 3+3 dose escalation and expansion study design, patients with ER+/HER2+ MBC were treated with sacibertinib (200mg-500mg daily) plus endocrine therapy including exe

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Sun, Yu, and Longhai Zhang. "Shakespeare across the Taiwan Strait: A Developmental Perspective." Multicultural Shakespeare: Translation, Appropriation and Performance 20, no. 35 (2019): 115–31. http://dx.doi.org/10.18778/2083-8530.20.09.

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Shakespeare studies in Mainland China and Taiwan evolved from the same origin during the two centuries after Shakespeare being introduced into China in the early nineteenth century. Although Shakespeare was first seen on the Taiwan stage in the Japanese language during the colonial period, it was after Kuomintang moved to Taiwan in 1949 that Shakespeare studies began to flourish when scholars and theatrical experts from mainland China, such as Liang Shih-Chiu, Yu Er-Chang, Wang Sheng-shan and others brought Chinese Shakespeare to Taiwan. Since the 1980s, mainland Shakespeareans began to commun

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Wang, Shu-Ping, Marvin Angelo Aberin, Saurabh Singh, et al. "Abstract 4839: Harnessing the cGAS-STING signaling and immune checkpoint pathways to enhance the tumor microenvironment for breast cancer immunotherapy." Cancer Research 85, no. 8_Supplement_1 (2025): 4839. https://doi.org/10.1158/1538-7445.am2025-4839.

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Abstract Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment, but resistance remains common with only some patients showing lasting responses. This underscores the need to understand resistance mechanisms and develop strategies to enhance responsiveness. In this study, we focus on breast cancer, particularly estrogen receptor-positive (ER+) breast cancer, which is generally poorly immunogenic and responds unfavorably to ICB. Upon analyzing the METABRIC cohort’s immunogenic biomarkers and tumor mutational burden (TMB), we found that relapsed ER+ patients treated with en

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Chen, Mei-Kuang, Xiaoting Jiang, Xiayu Rao, et al. "Abstract 358: INK4A/B as predictive biomarkers for enhanced efficacy of dual WEE1 and PKMYT1 inhibition in CDK4/6 inhibitor-resistant breast cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 358. https://doi.org/10.1158/1538-7445.am2025-358.

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Purpose: Although CDK4/6 inhibitors combined with endocrine therapy represent the standard of care for ER+/HER2- advanced breast cancer, resistance inevitably develops in a significant subset of patients, limiting effective treatment options. Similarly, patients with triple-negative breast cancer (TNBC) lacking BRCA mutations face an absence of targeted therapeutic strategies. These challenges underscore the urgent need for biomarker-driven targeted therapies in approximately 30% of breast cancer patients. Both CDK4/6 inhibitor-resistant (CDK4/6i-R) breast cancer and TNBC exhibit increased rep

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Yu, Kun, Tenghui Chen, Manav Korpal, et al. "Abstract 4123: Real-world data to identify the genomic association with response to CDK4/6i + Endocrine therapy in ER+ breast cancer patients." Cancer Research 82, no. 12_Supplement (2022): 4123. http://dx.doi.org/10.1158/1538-7445.am2022-4123.

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Abstract Background Real-world data (RWD) has been increasingly used for drug development. RWD coupled with genomic data provides an opportunity to identify the association between certain genomic alterations and response to current standard of care (SOC). Such analyses may help identify predictive biomarkers to select patients who will benefit most from SOC, and/or potential therapeutic nodes that can be pharmacologically targeted to overcome resistance to SOC. Methods We obtained Flatiron CGDB Breast Cancer (as of Q3 2020 release) data set. This data set includes clinical and genomic data fr

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Sagara, Akiko, Xiangdong Lv, Brandon Chen, et al. "Abstract PR-18: RNF43 Loss Induces an IRE1-dependent Metabolic Reprogramming in Pancreatic Cystic Neoplasms." Cancer Research 84, no. 17_Supplement_2 (2024): PR—18—PR—18. http://dx.doi.org/10.1158/1538-7445.pancreatic24-pr-18.

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Abstract Background: RNF43 is frequently mutated in intraductal papillary mucinous neoplasms (IPMNs), which are cystic precursor lesions of pancreatic ductal adenocarcinoma (PDAC). RNF43 encodes for an E3 ubiquitin ligase and was initially identified as a negative regulator of Wnt signaling in colorectal cancer. Clinical trials targeting ligand dependent Wnt signaling in RNF43-mutated cancers have failed to demonstrate any efficacy, suggesting other mechanisms may be involved. Methods: To elucidate the role of RNF43 in an organ specific context, we generated a genetically engineered mouse mode

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Wang, Lan-Hsin, Marvin Angelo E. Aberin, Saurabh Singh, et al. "Abstract A066: Enhancing breast cancer immunotherapy by modulating the cGAS–STING and CEACAM1–TIM3 pathways in the tumor microenvironment." Cancer Immunology Research 13, no. 2_Supplement (2025): A066. https://doi.org/10.1158/2326-6074.io2025-a066.

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Abstract Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment, delivering impressive results across various cancers. However, resistance is common, and only a limited number of patients experience lasting responses. This underscores the urgent need to understand resistance mechanisms and develop new strategies to enhance responsiveness. Here we focus on breast cancer, particularly ER+ breast cancer, which is generally poorly immunogenic and responds poorly to ICB. To address this, we analyzed the METABRIC cohort's immunogenic biomarkers and tumor mutational burden (TMB)

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Li, Hui-Ping, Guohong Song, Hanfang Jiang, et al. "Abstract PS15-07: Proxalutamide plus Endocrine Therapies in Women with HR+/HER2-/AR+ Metastatic Breast Cancer: A Phase Ic Study." Cancer Research 84, no. 9_Supplement (2024): PS15–07—PS15–07. http://dx.doi.org/10.1158/1538-7445.sabcs23-ps15-07.

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Abstract Abstract Background: Resistance to endocrine therapy (ET) and cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) is a major obstacle to the management of hormone-receptor (HR)+/human epidermal growth factor receptor 2 (HER2)- metastatic breast cancer (mBC). Targeting the AR signaling pathway has been demonstrated with promising results in this population. This phase Ic study aimed to assess the safety, efficacy, pharmacokinetic (PK), and pharmacodynamic (PD) characteristics of the combination of proxalutamide, a high-affinity AR antagonist, with ETs in androgen receptor (AR)+/HR+/HER2- m

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Zhao, Tianying, Shuai Xu, Jie Ping, et al. "Abstract 1716: A proteome-wide association study identifies putative causal proteins for breast cancer." Cancer Research 84, no. 6_Supplement (2024): 1716. http://dx.doi.org/10.1158/1538-7445.am2024-1716.

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Abstract Background: Genome-wide association studies (GWAS) have identified over 200 breast cancer risk associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function. In this study, we conducted a proteome-wide association study (PWAS) to identify proteins in breast tissue in relation to breast cancer risk. Methods: We profiled the proteome in breast tissue samples from 120 cancer-free European-ancestry women from the Susan G. Komen Tissue Bank. Protein expression levels were log2 transfe

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Lu, Haizhen, Dong Kuang, Lili Jiang, et al. "Abstract 5463: The PD-L1 protein expression in Chinese patients with recurrent or metastatic head and neck squamous cell carcinoma: A multi-center retrospective study." Cancer Research 83, no. 7_Supplement (2023): 5463. http://dx.doi.org/10.1158/1538-7445.am2023-5463.

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Abstract Programmed death-ligand 1 (PD-L1) is a trans-membrane protein and co-inhibitory factor of the immune response. PD-L1 can combine with its receptor (PD-1) to reduce the proliferation of PD-1-positive cells and induce apoptosis. Therefore, PD-L1 was employed as a prognostic marker and a target for anti-cancer immunotherapy in blocking the PD-1 and PD-L1 checkpoints. PD-L1 is highly expressed in various malignancies, including head and neck squamous cell carcinoma (HNSCC). HNSCC is the sixth most common cancer worldwide, with high incidence and mortality rates in China. Although PD-L1 ex

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Wen, Kuang-Yi, Suzanne Miller, Aruna Padmanabhan, Rita Smith, Emmanuel Lapitan, and Lori Goldstein. "Abstract B119: Effect of a smart pill bottle and text messaging-based intervention on medication adherence and side effect management in African American women with breast cancer new to endocrine therapy." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (2023): B119. http://dx.doi.org/10.1158/1538-7755.disp22-b119.

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Abstract Background For women with hormone receptor-positive breast cancer (BCa), approximately 75-80% of all BCa cases, long-term use of endocrine therapy has been demonstrated to improve disease free survival. However, data reported that non-adherence rates range from 28% to 59%, and African American (AA) women had lower odds of being adherent to endocrine therapy than other racial/ethnic groups, suggesting that medication adherence might be an important level for targeting racial disparities in AA BCa outcomes. Emerging adherence-promoting interventions using technologies to provide at-home

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Kubler, Kirsten, Agostina Nardone, Shankara Anand, et al. "Abstract GS2-09: Tamoxifen instigates uterine cancer development by activating PI3K signaling and supersedes PIK3CA driver mutations." Cancer Research 82, no. 4_Supplement (2022): GS2–09—GS2–09. http://dx.doi.org/10.1158/1538-7445.sabcs21-gs2-09.

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Abstract Tamoxifen is widely used in the adjuvant treatment of estrogen receptor–positive (ER+) breast cancer and is an important drug for pre-menopausal women and post-menopausal patients who cannot tolerate aromatase inhibitors. Despite the clear clinical benefit in improving relapse-free and overall survival in these patients, an adverse effect of tamoxifen is a 2- to 7-fold increased risk of uterine cancer (UC) after 2-5 years of treatment. To date, the mechanism of tamoxifen-driven tumorigenesis is not well understood, and preventive approaches are lacking. Here, to molecularly characteri

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Jabado, Omar, Suzana Couto, Jordan Blum, et al. "238 Molecular dissection of tumor-immune microenvironment factors associated with response to checkpoint inhibitor therapy in non-small cell lung cancer patients using nanostring digital spatial profiling." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A255—A256. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0238.

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BackgroundUnderstanding the dynamics of immune cells in the lung tumor microenvironment following immune checkpoint inhibitor (ICI) therapy is important for developing therapies tailored to patients with progressive disease. We sought to characterize protein and mRNA biomarkers in the tumor and stromal microenvironment in such patients with the Nanostring Digital Spatial Profiling (DSP) platform. DSP technology allows highly multiplexed profiling of proteins and RNA in a spatially resolved manner.MethodsFFPE non-small lung adenocarcinoma biopsies from 18 patients were sourced commercially (Cap

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Aberin, Marvin A., Yu-Ling (Pony) Lee, Xin-Guo Hsu, et al. "Abstract 3646: New functional role of tamoxifen in breast cancer immunomodulation: role of RACK7 in activation of type I interferon signaling and CEACAM1/TIM-3-dependent immunosuppression." Cancer Research 83, no. 7_Supplement (2023): 3646. http://dx.doi.org/10.1158/1538-7445.am2023-3646.

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Abstract Despite advancements of immunotherapy against various cancers, breast cancer still retains poor response to immune checkpoint blockade (ICB) therapy. Therefore, the identification of promising target or new strategy to enhance ICB therapy in breast cancer is crucial. Here, we uncover that the DNA-damaging potential of tamoxifen (TAM) can shape the unfavorable but ready-to-fire tumor immune microenvironment in breast cancer. We discover that a long-term TAM administration unexpectedly induces JAK/STAT signaling and Type I interferon (IFN)-stimulated gene expression to promote T-cell in

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Huang, Lisi, Xin Du, Jianyu Weng, et al. "Comparison of the 5 Year Medical Outcome and Quality of Life of Patients with Chronic Myeloid Leukemia Treated with Imatinib or Allogeneic Transplant." Blood 126, no. 23 (2015): 2118. http://dx.doi.org/10.1182/blood.v126.23.2118.2118.

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Abstract Comparison of the 5 year Medical Outcome and Quality of Life of Patients with Chronic Myeloid Leukemia treated with Imatinib or Allogeneic Transplant Jianyu Weng1*, Lisi Huang1*, Peilong Lai1, Zesheng Lu1, Ping Wu1, Suijing Wu1, Chengwei Luo1, Wei Ling1, Chenxin Deng1, Xin Huang1, Suxia Geng1, Xin Du1? 1Department of Hematology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, P.R. China. *These authors contributed equally to this work.? Corresponding author: Xin Du, MD, Ph.D. 106. Zhongshan Er Rd, Guangzhou, 510080, P.R. China E-mail: miyadu@hotmail.com P

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Liang, Yuehua, Hui Ping Li, and Zehui Yun. "Abstract C035: Chemotherapy plus HER2-targeted therapy versus endocrine therapy plus HER2-targeted therapy as first-line treatment in patients with HR+/HER2+advanced breast cancer: A real-world trial." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): C035. http://dx.doi.org/10.1158/1535-7163.targ-23-c035.

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Abstract Purpose:This study is a real-world research to compare the efficacy of using chemotherapy plus anti-HER2 therapy versus endocrine therapy plus anti-HER2 therapy as first-line treatment for HR+/HER+ advanced breast cancer patients, aiming at providing a better treatment option for patients. Patients and methods: This study enrolled patients with advanced breast cancer who had complete medical records and were treated in the breast oncology department of Peking University Cancer Hospital from October 2010 to October 2022. These patients were pathologically confirmed with HR+/HER2+ and u

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Niravath, Polly, Mailin Li, Jian Guan, et al. "Abstract RF1-07: Multifactor analysis for pathologic complete response (pCR) in a chemotherapy-free regimen of durvalumab, trastuzumab, and pertuzumab (DTP Trial) in HER2-enriched early breast cancer." Clinical Cancer Research 31, no. 12_Supplement (2025): RF1–07—RF1–07. https://doi.org/10.1158/1557-3265.sabcs24-rf1-07.

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Abstract Background: The treatment landscape for HER2-positive breast cancers has significantly changed in recent years with the expansion of anti-HER2 therapies, aiming to de-escalate or potentially eliminate use of standard cytotoxic agents. Previously, we demonstrated a 67.6% pathologic response rate (Residual Cancer Burden, RCB 0/1) using a chemotherapy-free regimen of durvalumab, trastuzumab, and pertuzumab in a biologically selected subset of HER2-enriched tumors. Here, we present preliminary analysis of multiple clinical and immune factors that contribute to achieving pCR. Methods: Betw

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Puca, Loredana, Michele S. Dowless, Carmen M. Perez-Ferreiro та ін. "Abstract P4-08-02: LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in preclinical PI3Kα H1047R-mutant breast cancer models". Cancer Research 83, № 5_Supplement (2023): P4–08–02—P4–08–02. http://dx.doi.org/10.1158/1538-7445.sabcs22-p4-08-02.

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Abstract Background Phosphoinositide 3-kinase alpha (PI3Kα) H1047R mutations are activating oncogenic events that occur in ~15% of breast cancers (BC). Early generation PI3Kα inhibitors target both wild-type (WT) and mutant PI3Kα and, as a result, their efficacy may be limited by on-target WT PI3Kα-mediated toxicities, including hyperglycemia, skin rash, and diarrhea. LOXO-783 is an oral, potent and highly mutant-selective, brain-penetrant allosteric PI3Kα H1047R inhibitor that is currently in phase 1 testing. Preclinically, LOXO-783 as a single agent is highly selective for PI3Kα H1047R over

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Luo, Ting, Xiaorong Zhong, Ping He, Dan Zheng, Yan Cheng, and Kunrui Zhu. "Abstract PO4-18-03: Combined Treatment with Pyrotinib and Chrysin Synergistically Improve the Autophagy Level in HER2-Positive Breast Cancer by Regulating the miR-16-5p/ZBTB16/G6PD Axis." Cancer Research 84, no. 9_Supplement (2024): PO4–18–03—PO4–18–03. http://dx.doi.org/10.1158/1538-7445.sabcs23-po4-18-03.

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Abstract Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) has been the most challenging subtype of BC, which consists of 20% of BC with an apparent correlation with poor prognosis. Despite that pyrotinib, a new HER2 inhibitor, has led to dramatic improvements in prognosis outcome, the efficacy of pyrotinib as monotherapy remain largely restricted due to its acquired resistance. Therefore, we aim at identifying a potent antitumor drug incorporated with pyrotinib for amplifying therapeutic efficacy for treating HER2-positive BC. Here, we reported a novel incorporation

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Grzegorczyk, Adrian, and Marcin Mamajek. "A 70 W thulium-doped all-fiber laser operating at 1940 nm." Photonics Letters of Poland 11, no. 3 (2019): 81. http://dx.doi.org/10.4302/plp.v11i3.928.

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An all-fiber thulium-doped fiber laser operating at a wavelength of 1940 nm is reported. A maximum output continuous-wave power of 70.7 W with a slope efficiency of 59%, determined with respect to the absorbed pump power, was demonstrated. The laser delivered almost a single-mode beam with a beam quality factor of < 1.3.Full Text: PDF ReferencesM. N. Zervas and C. A. Codemard, "High Power Fiber Lasers: A Review", IEEE J. Sel. Top. Quantum Electron. 20, 0904123 (2014). CrossRef D. J. Richardson, J. Nilsson, and W. A. Clarkson. "High power fiber lasers: current status and future perspectives

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Bloech, Michael, Markus Achatz, and Nicole Lohfink. "Berlinale 2018 – Politik und Filmkunst." merz | medien + erziehung 62, no. 2 (2018): 80–86. https://doi.org/10.21240/merz/2018.2.20.

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Die Berlinale hat seit Jahren einen ausgesprochen politischen Anspruch. In diesem Jahr waren hier die Erwartungen allerdings besonders hoch: Ausgelöst durch die #MeToo-Debatte und aufgrund der geringen Frauenquote in nahezu allen Bereichen der Filmindustrie, wurde gespannt darauf gewartet, welche Schwerpunkte das Festival setzen würde. Doch vielleicht war die Berlinale von der Dynamik dieses Themas überrascht worden, denn es kam nur zu einzelnen, wichtigen Aktivitäten. Aus dem riesigen Programmangebot sind Michael Bloech, Markus Achatz und Nicole Lohfink einige bemerkenswerte Geschichten in Er

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Nielsen, Klaus Bo. "Xunzis ritualanalyse." Religionsvidenskabeligt Tidsskrift, no. 51 (February 29, 2008). http://dx.doi.org/10.7146/rt.v0i51.1715.

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Denne artikel undersøger en oldkinesisk filosofs syn på ritualernes praksis i samspil med moderne sociologiske forståelser af religion. Den ritualteoretiker, jeg her vil beskæftige mig med, er de er n kinesiske forfatter Xunzi eller Xun Kuang (310-230 f. Kr.). I hans afhandling om ritualer (Li Lun) går han videre end blot at beskrive den rituelle akt, og anlægger en mere distanceret indstilling til ritualet og skitserer dermed en sociologisk baseret ritualteori, som har lighedspunkter med klassiske positioner som Durkheim, Radcliff-Brown og Rappaport. Det er i dette lys, at Xunzis ritualteor

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Pileberg, Silje. "Stabile tal for sjølvmord i Noreg." Suicidologi 25, no. 3 (2021). http://dx.doi.org/10.5617/suicidologi.8543.

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Yang, Fang, Yonghui Yu, and Hong Liu. "Mechanism of Action of Yikun Yitong Ping-Containing Serum on Mast Cells and its Possible Involvement in Endometriosis-Related Dysmenorrhea." Natural Product Communications 19, no. 2 (2024). http://dx.doi.org/10.1177/1934578x241229929.

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Background Previously, we showed that Yikun Yitong Ping (YKYTP) can effectively and safely relieve endometriosis-related dysmenorrhea; however, the underlying mechanism remained unclear. This study aimed to assess the effects of YKYTP-containing serum on rat basophilic leukemia cell line, as mast cells (MCs) analog, and investigate the mechanisms by which YKYTP alleviates endometriosis-related dysmenorrhea. Method In this study, YKYTP drug-containing serum was used to treat rat basophilic leukemia cell line (RBL2H3). The effect of YKYTP-containing serum on the expression of ER-α, ER-β, NGF, an

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Hamsho, Suaad, Sumaya Dumirieh, Mouhammed Sleiay, Douha AlBaroudi, Muhamad Ali Alshekh, and Marwa Alahmad. "Pauci‐immune necrotizing glomerulonephritis in a 24‐year‐old female with negative ANCA antibodies: A rare case report." Clinical Case Reports 12, no. 8 (2024). http://dx.doi.org/10.1002/ccr3.9258.

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Key Clinical MessagePauci‐immune necrotizing glomerulonephritis (PING) is a small vessel renal vasculitis usually associated with the presence of antineutrophil cytoplasmic antibodies (ANCA) against myeloperoxidase or proteinase. A small proportion of PING patients do not have ANCA antibodies.AbstractA condition known as Pauci‐immune necrotizing glomerulonephritis, or PING for short, is a type of kidney inflammation that affects small blood vessels. This condition is typically linked with the existence of certain antibodies, specifically antineutrophil cytoplasmic antibodies or ANCA, which tar

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Porto-Lefébure, Alessia Lo, and Gyöngyvér Völgyes. "Amikor Peking a Harvardot utánozza – képzés amerikai módra kínai vezetők számára." March 15, 2021. https://doi.org/10.5281/zenodo.6894302.

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Hszi Csin-ping nem győzi kritizálni a &bdquo;nyugati értékeket”, és előtérbe helyezni a &bdquo;kínai erényeket”. Országa hatóságai a kínai funkcionáriusok képzésére mégis a nagybecsű Harvard Egyetem Közigazgatási Főiskolájának programját fogadták el. Tisztviselők ezrei vesznek részt a hazai kontextushoz igazított mesterképzésben, amelyet 2000-ben indítottak.

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Paes, Ticiana, Jacobo Buelvas Mebarak, John C. Magnotto, et al. "7826 The Identification of an Activating ESR1 Mutation in an Aggressive Prolactinoma Enabled the Use of Personalized Treatment." Journal of the Endocrine Society 8, Supplement_1 (2024). http://dx.doi.org/10.1210/jendso/bvae163.1349.

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Abstract Disclosure: T. Paes: None. J.B. Mebarak: None. J. C. Magnotto: None. G. A. Stamatiades: None. Y. Kuang: None. C. Paweletz: None. E.R. Laws: None. R.S. Carroll: None. R. Jeselsohn: None. D. R. Mohan: None. A. Marcondes Lerario: None. W. L. Bi: None. D. A. Reardon: None. D. M. Meredith: None. U.B. Kaiser: None. A. Abreu: None. Introduction: Prolactinomas are benign tumors typically treated with dopamine agonists; few progress on medical therapy, through unclear molecular mechanisms. Although the SF3B1 mutation has been identified in one study as a driver of aggressive prolactinomas, in

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Dung, Nguyen Thi, Hoang Van Thanh, and Nguyen Dinh Lam. "Influences of Growth Durations on Characteristics of NaYF4:(Yb,Tm) Upconversion Materials." VNU Journal of Science: Natural Sciences and Technology 35, no. 4 (2019). http://dx.doi.org/10.25073/2588-1140/vnunst.4965.

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NaYF4:(Yb,Tm) upconversion materials were synthesized by the simple hydrothermal method. Growth duration was varied from 4h to 12h under a growth temperature of 150oC. The structural, optical and surface morphology characteristics of the NaYF4:(Yb,Tm) UC materials were investigated. The XRD and SEM results illustrated that the NaYF4:(Yb,Tm) materials were transformed from the multiple phases (hexagonal and cubic) to the single-phase (hexagonal prism) as growth duration being longer than 8h with the average diameter and length of these prisms being about 0.5 µm and 2 µm, respectively. Under 980

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Henry, Jacobs. "Xunzi 荀子". Database of Religious History, 27 червня 2024. https://doi.org/10.5281/zenodo.12572692.

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The Xunzi is a work of Early Chinese philosophy that played a key role in consolidating what later became known as Confucian thought. The text is associated with the eponymous figure Xunzi ("Master Xun") - also known by his name Xun Kuang 荀況 or his title Xun Qing 荀卿 ("Minister Xun") - who lived during the Warring States period (453-221 BCE). Defending and critiquing Confucius (trad. 551-479 BCE) and Mencius (371-289 BCE?), the Xunzi is often regarded today as the most sophisticated expression of Early Confucian thought. The recent surge of interest in the Xunzi starkly contrasts the work's mix

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