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Chao, Xue-lin, Shu-zhen Jiang, Jian-wen Xiong, Jin-qiong Zhan, Bo Wei, Chun-nuan Chen, and Yuan-jian Yang. "Erratum to: Changes of Serum Insulin-like Growth Factor-2 Response to Negative Symptom Improvements in Schizophrenia Patients Treated with Atypical Antipsychotics." Current Medical Science 40, no. 5 (October 2020): 997. http://dx.doi.org/10.1007/s11596-020-2256-3.
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The article “Changes of Serum Insulin-like Growth Factor-2 Response to Negative Symptom Improvements in Schizophrenia Patients Treated with Atypical Antipsychotics”, written by Xue-lin CHAO, Shu-zhen JIANG, Jian-wen XIONG, Jin-qiong ZHAN, Bo WEI, Chun-nuan CHEN, Yuan-jian YANG was originally published electronically on the publisher’s internet portal on June 2020 without open access. With the author(s)’ decision to opt for Open Choice, the copyright of the article is changed to © The Author(s) 2020 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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WU, Peichen. "Traveling Japan, Writing Japan：The Translation and Publishing of the Travelogue Wareteki Nihon." Border Crossings: The Journal of Japanese-Language Literature Studies 13, no. 1 (December 30, 2021): 53–60. http://dx.doi.org/10.22628/bcjjl.2021.13.1.53.
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The travelogue Wareteki Nihon was published in December 2018 by Hakushui Sha, and included the work of eighteen Taiwanese writers from various generations. All their works in the text relate to their travels in Japan. These Taiwanese writers are Kan Yao-Ming, Ko Yu-fen, Huang Li-Chun, Wang Sheng-Hong, Jiang E, Chen Bo-Chin, Hu Mu-Ching, Sheng Hao-We, Chu He-Chih, Wu Ming-Yi, Lu Hui-Hsin, Yi Ge-Yan, Yen Shu-Hsia, and Liu Shu-Hui, whose works in this anthology depict Japanese scenery, culture and literature, and so on. This paper will focus on how this publishing project started, the process of producing this travelogue, and the evaluations and responses of Japan’s literary circle and the mass media to it after its publication in Japan.
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Gao, Zhen, and Guanghui Hu. "High Order Well-Balanced Weighted Compact Nonlinear Schemes for the Gas Dynamic Equations under Gravitational Fields." East Asian Journal on Applied Mathematics 7, no. 4 (November 2017): 697–713. http://dx.doi.org/10.4208/eajam.181016.300517g.
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AbstractIn this study, we propose a high order well-balanced weighted compact nonlinear (WCN) scheme for the gas dynamic equations under gravitational fields. The proposed scheme is an extension of the high order WCN schemes developed in (S. Zhang, S. Jiang, C.-W Shu, J. Comput. Phys. 227 (2008) 7294-7321). For the purpose of maintaining the exact steady state solution, the well-balanced technique in (Y. Xing, C.-W Shu, J. Sci. Comput. 54 (2013) 645-662) is employed to split the source term into two terms. The proposed scheme can maintain the isothermal equilibrium solution exactly, genuine high order accuracy and resolve small perturbations of the hydrostatic balance state on the coarse meshes. Furthermore, in order to capture the strong discontinuities and large gradients, the fifth-order upwind weighted nonlinear interpolations together with the fourth/sixth order cell-centered compact schemes with local characteristic projections are used to construct different WCN schemes. Several representative one- and two-dimensional examples are simulated to demonstrate the good performance of the proposed schemes.
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Gao, Zhen, and Guanghui Hu. "High Order Well-Balanced Weighted Compact Nonlinear Schemes for Shallow Water Equations." Communications in Computational Physics 22, no. 4 (July 28, 2017): 1049–68. http://dx.doi.org/10.4208/cicp.oa-2016-0200.
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AbstractIn this study, a numerical framework of the high order well-balanced weighted compact nonlinear (WCN) schemes is proposed for the shallow water equations based on the work in [S. Zhang, S. Jiang, C.-W Shu, J. Comput. Phys. 227 (2008) 7294-7321]. We employ a special splitting technique for the source term proposed in [Y. Xing, C.-W Shu, J. Comput. Phys. 208 (2005) 206-227] to maintain the exact C-property, which can be proved theoretically. In the meantime, the genuine high order accuracy of the numerical scheme can be observed successfully, and small perturbation of the stationary state can be resolved and evolved well. In order to capture the strong discontinuities and large gradients, the fifth-order upwind weighted nonlinear interpolations together with the fourth/sixth order cell-centered compact scheme are used to construct different WCN schemes. In addition, the local characteristic projections are considered to further restrain the potential numerical oscillations. A variety of representative one- and two-dimensional examples are tested to demonstrate the good performance of the proposed schemes.
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Lan, Tuo, Mei Wang, AnnaLynn M. Williams, Matthew J. Ehrhardt, Emily R. Finch, Jennifer Q. Lanctot, Shu Jiang, et al. "Abstract B004: Sugar Intake and premature aging in adult survivors of childhood cancer in the St. Jude Lifetime (SJLIFE) Cohort." Cancer Research 83, no. 2_Supplement_1 (January 15, 2023): B004. http://dx.doi.org/10.1158/1538-7445.agca22-b004.
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Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is available in the Short Talks from Proffered Abstracts section (PR014) of the Conference Proceedings. Citation Format: Tuo Lan, Mei Wang, AnnaLynn M. Williams, Matthew J. Ehrhardt, Emily R. Finch, Jennifer Q. Lanctot, Shu Jiang, Kevin R. Krull, Gregory T. Armstrong, Melissa M. Hudson, Graham A. Colditz, Leslie Robison, Kirsten K. Ness, Yikyung Park. Sugar Intake and premature aging in adult survivors of childhood cancer in the St. Jude Lifetime (SJLIFE) Cohort [abstract]. In: Proceedings of the AACR Special Conference: Aging and Cancer; 2022 Nov 17-20; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_1):Abstract nr B004.
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조성천 and 이상훈. "The Translation and Annotation of Two Pieces of Shu Hou(書後) in Wang Fu-zhi's Jiang Zhāi Wen Ji." Journal of Chinese Language and Literature ll, no. 65 (October 2014): 355–74. http://dx.doi.org/10.26586/chls.2014..65.013.
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Xianzhao, Fu, Huang Guangming, Li Chunyan, Huang Wenhua, Qiu Haixian, Qiu Siyuan, Bi Honghan, Cao Qiuxia, and Lu Mian. "Inhibition of Jiang Tang Shu Xin (JTSX) Recipe in Endoplasmic Reticulum Stress CHOP Pathway and Improving Myocardial Remodeling in SD Diabetic Rats." Science Journal of Public Health 7, no. 6 (2019): 225. http://dx.doi.org/10.11648/j.sjph.20190706.17.
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SHU, BIN, and YU-FENG YAO. "ON CARTAN INVARIANTS FOR GRADED LIE ALGEBRAS OF CARTAN TYPE." Journal of Algebra and Its Applications 13, no. 03 (October 31, 2013): 1350101. http://dx.doi.org/10.1142/s0219498813501016.
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Let L = X(m; n), X ∈ {W, S, H, K}, be a graded simple Lie algebra of Cartan type over an algebraically closed field of characteristic p > 3. Then L is a so-called generalized restricted Lie algebra. Let [Formula: see text] be the primitive p-envelope of L, and G = X(m; 1), a subalgebra of [Formula: see text]. In this paper, a close connection between Cartan invariants for [Formula: see text] and U(G, χ) is established, where χ ∈ L* is extended to be a linear function on [Formula: see text] trivially, and 1 ≤ ht (χ) < p-2+δXW. This reduces the study of projective representations of the generalized restricted Lie algebra L to the one of the corresponding restricted Lie algebra G. As a special case, we recover some results in [Shu and Jiang, On Cartan invariants and blocks of Zassenhaus algebras, Comm. Algebra33(10) (2005) 3619–3630].
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Chu, Pingyi. "Anjing Qu. Zhongguo jin xian dai ke ji jiang li zhi du [Science and Technology Awards in Modern China]. (Zhongguo jin xian dai ke xue ji shu shi yan jiu cong shu.). 329 pp., tables, bibl., index. Jinan: Shandong jiao yu chu ban she [Shandong Education Press], 2005. (Paper.)." Isis 99, no. 2 (June 2008): 444–45. http://dx.doi.org/10.1086/591383.
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Fang, Li-Zhi. "Jiang Xiaoyuan ;, Wu Yan . Zijin shan tian wen tai shi gao: Zhongguo tian wen xue xian dai hua ge an. [History of Purplemountain Observatory.] (Zhongguo jin xian dai ke xue ji shu shi yan jiu cong shu.). 219 pp., tables, bibl., index. Jinan: Shandong jiao yu chu ban she [Shandong Education Press], 2004. 29 (paper)." Isis 99, no. 3 (September 2008): 645–46. http://dx.doi.org/10.1086/593267.
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Guan, Li-Zeng, Qian-Yun Xi, Yu-Ping Sun, Jing-Lan Wang, Jun-Yun Zhou, Gang Shu, Qing-Yan Jiang, and Yong-Liang Zhang. "Intestine-specific expression of the β-glucanase in mice." Canadian Journal of Animal Science 94, no. 2 (June 2014): 287–93. http://dx.doi.org/10.4141/cjas2013-125.
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Guan, L.-Z., Xi, Q.-Y., Sun, Y.-P., Wang, J.-L., Zhou, J.-Y., Shu, G., Jiang, Q.-Y. and Zhang, Y.-L. 2014. Intestine-specific expression of the β-glucanase in mice. Can. J. Anim. Sci. 94: 287–293. The β-glucanase gene (GLU, from Paenibacillus polymyxa CP7) was cloned into a specific expression plasmid (MUC2-GLU-LV). Transgenic mice were prepared by microinjection. Polymerase chain reaction and Southern blot analysis of genomic DNA extracted from the tail tissue of transgenic mice showed that the mice carried the β-glucanase gene. Northern blot analysis indicated that β-glucanase was specifically expressed in the intestine of the transgenic mice. The β-glucanase activity in the intestinal contents was found to be 1.23±0.32 U mL−1. The crude protein, crude fat digestibility of transgenic mice were increased by 9.32 and 5.09% (P<0.05), respectively, compared with that of the non-transgenic mice, while moisture in feces was reduced by 12.16% (P<0.05). These results suggest that the expression of β-glucanase in the intestine of animals offers a promising biological approach to reduce the anti-nutritional effect of β-glucans in feed.
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Editorial, E. "Retraction: Shuang-Qing L, Jiang-Ying G, Qun D, Zhong-Jie H, Shu-Hong L. Anticoagulant effect of Huisheng Oral Solution in a rat model of thrombosis. Arch biol sci. 2013;65(3):1223-31. DOI: 10.2298/ABS1303223L." Archives of Biological Sciences 67, no. 4 (2015): 1435. http://dx.doi.org/10.2298/abs150707082e.
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This is a notice of retraction of the article: Anticoagulant effect of Huisheng Oral Solution in a rat model of thrombosis, published in the Archives of Biological Sciences in 2013, Vol. 65, Issue 3. The Editor-in-Chief has been informed that this paper is a redundant publication of an earlier paper: Shuang-Qing L, Jian-Ying G, Jun D, Qun D, Zhong-Jie H, Hong-Yuan L, Shu-Hong L. Anticoagulant effect of Huisheng oral solution in a rat model of thrombosis. Indian J Pharmacol. 2013;45(4):359-64. DOI: 10.4103/0253-7613.115018. This claim is correct and almost the entire paper is a copy of the earlier one. After confirmation of this fact, the Editor-in-Chief of the Archives of Biological Sciences has decided to retract the paper immediately. <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/ABS1303223L">10.2298/ABS1303223L</a></b></u>
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Yeh, Michelle. "The “Cult of Poetry” in Contemporary China." Journal of Asian Studies 55, no. 1 (February 1996): 51–80. http://dx.doi.org/10.2307/2943636.
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A renaissance in literature and art took place in the People's Republic of China from the late 1970s through the 1980s. In poetry, the outburst of vitality first showed itself in 1978–80 in the underground Today (Jintian) group, which included cofounders and editors Bei Dao (b. 1949) and Mang Ke (b. 1951), and such contributors as Jiang He (b. 1949), Shu Ting (b. 1952), Gu Cheng (1956–93), and Yang Lian (b. 1955), to name only a few of the best-known in the West. Today lent momentum to the flourish of Menglongshi, commonly translated as “Obscure Poetry” or “Misty Poetry,” in the early 1980s and became the major source of inspiration—no less than the target of criticism and revolt—to post-Menglong poetry in the second half of the decade. Like Menglongsbi, post-Menglong poetry is a term of inevitable, even misleading, simplification, since it refers to a wide range of varying styles and modes of writing. Rather than being unified by a set of formal and stylistic characteristics, it is marked by a radical openness to experimentation. The multiplicity of experiments in poetry since the mid-1980s may be more broadly and appropriately referred to as avant-garde poetry or experimental poetry (Yeh 1992). This paper will focus on an interesting—and unique in today's world—phenomenon that I call the “cult of poetry.” I will first examine the “cult” by defining its salient features and then present a critical analysis of the diverse historical and psychological forces that contribute to such a literary phenomenon.
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McNair, Amy. "Two Chinese Treatises on Calligraphy: Treatise on Calligraphy (Shu pu), by Sun Qianli; Sequel to the “Treatise on Calligraphy” (Xu shu pu) by Jiang Kui. Introduced, translated, and annotated by Chang Ch'ung-Ho and Hans H. Frankel. New Haven, Conn.: Yale University Press, 1995. xv, 144 pp. $25.00." Journal of Asian Studies 58, no. 3 (August 1999): 793–95. http://dx.doi.org/10.2307/2659132.
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Smith, Richard J. "Zhongguo Gudai Suanming Shu [The Divinatory Arts of Ancient China]. By Hong Pimo and Jiang Yuzhen. Shanghai: The People's Publishing House, 1990. Revised edition, iv, 277 pp. RMB 3.25 (HK $17.00; Joint Publishing Company)." Journal of Asian Studies 51, no. 4 (November 1992): 895–96. http://dx.doi.org/10.2307/2059063.
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随机电磁涡旋光束的深聚焦特性. "Tight Focusing of Stochastic Electromagnetic Vortex Beams." ACTA PHOTONICA SINICA 40, no. 11 (2011): 1744–50. http://dx.doi.org/10.3788/gzxb20114011.1744.
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김양순. "Forty Eight Vows in Wu-liang-shou-jing-lian-yi-shu-wen-zan." BUL GYO HAK YEONGU-Journal of Buddhist Studies 18, no. ll (December 2007): 295–318. http://dx.doi.org/10.21482/jbs.18..200712.295.
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Choi, Hyung-Lok, and Duk Kyung Choi. "A study on the ‘Vegetable(Shu-Cai)’ in the Shi-Jing(詩經)." Chinese Studies 49 (December 30, 2014): 165–84. http://dx.doi.org/10.14378/kacs.2014.49.49.165.
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Shaotang, Liu. "Hu Shi and Jiang Jieshi." Chinese Studies in History 42, no. 1 (September 2008): 47–60. http://dx.doi.org/10.2753/csh0009-4633420102.
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Jiang, Shu (Joy), and Graham A. Colditz. "Abstract B014: Improving prediction of second events after DCIS using whole breast mammogram images." Cancer Prevention Research 15, no. 12_Supplement_1 (December 1, 2022): B014. http://dx.doi.org/10.1158/1940-6215.dcis22-b014.
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Abstract Purpose: We aim to improve prediction of subsequent events after DCIS. Current models show relatively poor performance predicting subsequent events and often are limited to ipsilateral events. National population-based SEER data including over160,000 cases of DCIS and followed an average of 90 months indicate that second events (including risk of invasive breast cancer – IBC) are equality likely in the ipsilateral and contralateral breast. Thus, additional information on risk may be obtained by more complete modeling of risk estimating recurrence. Mammographic images have been largely ignored despite evidence that even breast density improves prediction of breast cancer in the general population. Furthermore, we have shown whole breast mammogram images (WBI) included in Cox models significantly improves prediction of breast cancer risk over using mammographic breast density alone and breast cancer risk factors. Population: We retrieved digital mammograms for women diagnosed with DCIS at Washington University School of Medicine from 2008 onwards and followed for subsequent diagnosis of pathology confirmed breast lesions. Using more than 100 cases and controls matched on year of mammogram and age we fit Cox models to evaluate risk of ipsilateral invasive breast cancer. To compare and accommodate laterality of subsequent breast lesions, we fit competing risk models using baseline covariates that are available on the women-level as well as WBI that are side-specific. Results: Preliminary analysis shows WBI predicts subsequent invasive breast cancer. Further, we will demonstrate appropriate models adjusting for competing risk gives unbiased estimates of invasive breast cancer. Conclusion: WBI and competing risk analysis improves our understanding of associations for side of occurrence of subsequent breast lesions after an initial diagnosis of DCIS. Citation Format: Shu (Joy) Jiang, Graham A. Colditz. Improving prediction of second events after DCIS using whole breast mammogram images [abstract]. In: Proceedings of the AACR Special Conference on Rethinking DCIS: An Opportunity for Prevention?; 2022 Sep 8-11; Philadelphia, PA. Philadelphia (PA): AACR; Can Prev Res 2022;15(12 Suppl_1): Abstract nr B014.
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Unschuld, P. U. "Huang Di Nei Jing Ling Shu." Deutsche Zeitschrift für Akupunktur 58, no. 3 (2015): 14–19. http://dx.doi.org/10.1016/s0415-6412(15)30036-9.
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Wei, Heyi, and Wenhua Jiang. "Translation of the ‘Landscape Architecture’ Into Chinese and How to Build the Discipline of Landscape Architecture in China?" International Research in Education 8, no. 1 (February 3, 2020): 104. http://dx.doi.org/10.5296/ire.v8i1.16381.
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The translation and connotation of landscape architecture (LA) caused a lot of controversy in academia when the term ‘LA’ was introduced to China. In this study, we summarized the different opinions of Chinese scholars based on the origin, evolution, and professional contents of LA, which can be divided into ‘Jing Guan Jian Zhu’ (Chinese Pinyin), ‘Jing Guan She Ji’, and ‘Feng Jing Yuan Lin’. Finally, this article provides strategies and suggestions for enhancing the development of LA when the first-level discipline is established in China, and the aim is to narrow the gap with the international community.
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Jouve, Jean-Luc. "Expert’s comment concerning Grand Rounds case entitled “Langerhans cell histiocytosis of the atlas in an adult” (by Wo Quan Zhong, Liang Jiang, Qing Jun Ma, Zhong Jun Liu, Xiao Guang Liu, Feng Wei, Hui Shu Yuan, Geng Ting Dang)." European Spine Journal 19, no. 1 (October 23, 2009): 23–24. http://dx.doi.org/10.1007/s00586-009-1173-8.
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Fourney, Daryl R. "Expert’s Comment concerning Grand Rounds case entitled “Aggressive vertebral hemangioma of the thoracic spine without typical radiological appearance” (Lei Dang, Chen Liu, Shao Min Yang, Liang Jiang, Zhong Jun Liu, Xiao Guang Liu, Hui Shu Yuan, Feng Wei, Miao Yu)." European Spine Journal 21, no. 10 (June 26, 2012): 2000–2002. http://dx.doi.org/10.1007/s00586-012-2384-y.
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Gosch, Sabine. "Goldimplantation in Shu-Punkte schwächt das Nieren-Jing." Zeitschrift für Ganzheitliche Tiermedizin 23, no. 02 (May 22, 2009): 48–49. http://dx.doi.org/10.1055/s-0029-1185618.
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Wu, Jiong, Zhenzhen Liu, Hongjian Yang, Jinhai Tang, Kun Wang, Yunjiang Liu, Haibo Wang, et al. "Abstract PD8-08: Pyrotinib in combination with trastuzumab and docetaxel as neoadjuvant treatment for HER2-positive early or locally advanced breast cancer (PHEDRA): A randomized, double-blind, multicenter, phase 3 study." Cancer Research 82, no. 4_Supplement (February 15, 2022): PD8–08—PD8–08. http://dx.doi.org/10.1158/1538-7445.sabcs21-pd8-08.
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Abstract Background: Pyrotinib (an irreversible pan-ErbB inhibitor) plus capecitabine have shown clinically and statistically meaningful progression free survival and overall survival benefits and acceptable tolerability in patients with HER2-positive metastatic breast cancer in phase 3 study. We compared the efficacy and safety of adding pyrotinib to trastuzumab and docetaxel vs placebo, trastuzumab and docetaxel as neoadjuvant treatment in women with HER2-positive early or locally advanced breast cancer (ABC) in this randomized, double-blind, multicenter, phase 3 study. Methods: Treatment naive patients with HER2-positive early or locally ABC (T2-3, N0-3, M0) were randomly assigned (1:1) to pyrotinib arm receiving 4 neoadjuvant cycles of pyrotinib (400 mg po qd, d1-21, q3w), trastuzumab (8 mg/kg iv, cycle 1 d1, then 6 mg/kg d1 q3w) and placebo arm with docetaxel (100 mg/m2 iv d1, q3w) or placebo, trastuzumab and docetaxel. Randomization was done via a centralized interactive web-response system and stratified by primary tumor size (>2 cm and ≤5cm, or >5cm) and hormone receptor status (ER positive and/or PR positive, or negative for both). After surgery, patients received 3 cycles of intravenous fluorouracil, epirubicin, and cyclophosphamide followed by anti-cancer treatment (anti-HER2 therapy, radiotherapy, or endocrine therapy) at physicians’ discretion in accordance with clinical practice guidelines. The primary endpoint was total pCR rate (tpCR; defined as absence of any residual invasive cancer in the breast and lymph nodes [ypT0/is, ypN0]), assessed by an independent review committee (IRC). This study is registered with ClinicalTrials.gov, number NCT03588091. The data cutoff date was April 30, 2021. Results: Between July 23, 2018 and January 8, 2021, a total of 355 patients were randomized (pyrotinib arm, n=178; and placebo arm, n=177; mean [SD] age, 48.8 [9.4] years). Baseline demographics and disease characteristics were well balanced. In the full analysis set, IRC-assessed tpCR rates were 41.0% (73 of 178) in the pyrotinib arm and 22.0% (39 of 177) in the placebo arm (difference, 19.0% [95% CI, 9.5%-28.4%]; one-sided P<0.0001). The local pathologist-assessed tpCR rates were 44.4% (79 of 178) and 24.3% (43 of 177) in the pyrotinib arm and the placebo arm, respectively. Incidence of grade ≥3 adverse events (AEs) was 71.3% (127 of 178) in the pyrotinib arm and 37.3% (66 of 177) in the placebo arm. Of the most-common grade ≥3 AEs (≥5% of patients in either arm), the incidences of diarrhea (79 of 178 [44.4%] vs 9 of 177 [5.1%]), decreased WBC count (29 of 178 [16.3%] vs 24 of 177 [13.6%]), vomiting (23 of 178 [12.9%] vs 2 of 177 [1.1%]), anemia (11 of 178 [6.2%] vs 2 of 177 [1.1%]), and hypokalemia (9 of 178 [5.1%] vs 0) were higher in the pyrotinib arm compared with the placebo arm. Grade 3 diarrhea occurred mainly during the first treatment cycle and decreased in the second cycle and thereafter. No grade 4 or 5 diarrheas occurred. The median duration per grade 3 episode was 2.0 days and median cumulative duration of grade 3 episodes was 4.0 days. Only 1 patient (1 of 178 [0.6%]) in the pyrotinb arm experienced diarrhea-related discontinuation. Serious AEs were reported in 14.6% of patients (26 of 178) in the pyrotinib arm and 6.8% of patients (12 of 177) in the placebo arm. Conclusions: Pyrotinib, trastuzumab, and docetaxel as neoadjuvant treatment achieved a statistically significant and clinically meaningful improvement in IRC-assessed tpCR rate for patients with HER2-positive early or locally ABC compared with placebo, trastuzumab, and docetaxel, with an acceptable and manageable safety profile. These findings support pyrotinib, trastuzumab, and docetaxel as a new neoadjuvant treatment option in this patient population. Citation Format: Jiong Wu, Zhenzhen Liu, Hongjian Yang, Jinhai Tang, Kun Wang, Yunjiang Liu, Haibo Wang, Peifen Fu, Shuqun Zhang, Qiang Liu, Zefei Jiang, Shusen Wang, Jian Huang, Chuan Wang, Shu Wang, Yongsheng Wang, Linlin Zhen, Xiaoyu Zhu, Fei Wu, Tao Zhang, Jianjun Zou. Pyrotinib in combination with trastuzumab and docetaxel as neoadjuvant treatment for HER2-positive early or locally advanced breast cancer (PHEDRA): A randomized, double-blind, multicenter, phase 3 study [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr PD8-08.
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김혜정. "A Study on the Bearing Ideas in Qin Han Jian Ri Shu - Focused on Zhou Jia Tai and Shui Hu Di Qin Jian Ri Shu and Kong Jia Po Han Jian Ri Shu." Journal of Study on Language and Culture of Korea and China ll, no. 33 (October 2013): 609–38. http://dx.doi.org/10.16874/jslckc.2013..33.025.
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Stezhenskaya, Lidiya V. "A Propos the Failed First Publication of the Russian Translation of Shu Jing." RUDN Journal of Philosophy 25, no. 2 (December 15, 2021): 320–27. http://dx.doi.org/10.22363/2313-2302-2021-25-2-320-327.
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The Book of Historical Documents (Shu jing) is an ancient Chinese written monument, a collection of addresses of the ruler to the subjects and of the subjects to the rulers. The philosophical meaning of Shu jing is that it mentions or refers to the issues of a broad ideological order. These brief references either gave life to philosophical ideas, or later, after appropriate interpretation, were used by the philosophers to authoritatively confirm their thoughts. The first complete Russian translation of Shu jing was done by Archimandrite Daniil (Dmitriy Petrovich Sivillov, 1789-1871) in the early 40s of the 19th century. The translation was undertaken, first and primarily, as a teaching material assigned to students of the Chinese Language Cathedra at the Kazan Imperial University. This cathedra was first one established in Russia and the second one in Europe. Archimandrite Daniel was its first head in 1837-1844. Unfortunately, the translator have never had a chance to publish his work. Sivillov for the first time in Russian and European Sinology used a purely Chinese commented edition of The Book . The canonical text used by Sivillov and later his followers was considered and understood through the prism of modern Neoconfucianism, which, in comparison with ancient and early medieval Confucianism, reinterpreted and significantly enriched the philosophical meaning of the Shu jing . In some points of understanding of the Neoconfucian interpretation of the ancient text, Archimandrite Daniil was not only ahead of, but also more successful than his later colleagues. The text of the previously unpublished Shu jing Chapter III Da Yu mo Russian translation by archimandrite Daniil is attached.
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Shaughnessy, Edward L. "A Possible Lost Classic: The *She ming, or *Command to She." T’oung Pao 106, no. 3-4 (September 4, 2020): 266–308. http://dx.doi.org/10.1163/15685322-10634p02.
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Abstract Volume 8 of Qinghua daxue cang Zhanguo zhujian 清華大學藏戰國竹簡 contains a manuscript entitled by the editors *She ming 攝命 (*Command to She), which they argue is the original version of the ancient-script “Jiong ming” 囧命 (“Command to Jiong”) chapter of the Shangshu 尚書. I review the evidence for this and further provide a full translation of the text. I also consider possible implications of the *She ming for Western Zhou history, and how the text may have been transmitted from the time of its original composition, perhaps in the ninth century BCE, to the time that the Tsinghua manuscript was copied, probably in the fourth century BCE.
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JUN, REN, and JIANG YUN. "The Fifty-Year Relationship Between Hu Shi and Jiang Tingfu." Chinese Studies in History 39, no. 1 (October 2005): 25–63. http://dx.doi.org/10.1080/00094633.2005.11039502.
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Jiang, Shu, and Graham A. Colditz. "Abstract LB161: Whole mammogram image improves breast cancer prediction." Cancer Research 82, no. 12_Supplement (June 15, 2022): LB161. http://dx.doi.org/10.1158/1538-7445.am2022-lb161.
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Abstract To efficiently capture data from mammographic breast images and classify long term risk of breast cancer, we developed methods that use the extensive existing data that are currently ignored in the context of breast cancer risk stratification. More than 20 studies support texture features add value to risk prediction beyond breast density. However, the entire mammogram imaging data has a high dimension of pixels (~13 million per image), greatly exceeding the number of women in a cohort. We apply functional principal component analysis methods to predict 5-years breast cancer incidence using baseline mammograms. We applied these methods onto women participating in the Joanne Knight Breast Health Cohort which is comprised of over 10,000 women undergoing repeated mammography screening at Siteman Cancer Center and followed since 2010. All women had baseline mammogram at entry, provided a blood sample and completed a risk factor questionnaire. Mammograms are all using the same technology (Hologic). During follow-up through October 2020, we identified 246 incident breast cancer cases (pathology confirmed) and matched them to controls from the perspective cohort based on month of mammogram and age at entry. In a baseline model we controlled for age, menopause, BMI, and mammographic breast density (BIRADs). We then added the full image (characterized by the FPC) to the base model and further compared the AUC of the new model vs the base model using the likelihood ratio test. AUC is validated with internal 10-fold cross validation. The AUC for 5-year breast cancer risk classification increased significantly from a median of 0.61 (sd 0.09 for estimated AUCs across 10-fold internal validation) for the baseline model to 0.70 (0.10) when the full image is added, p < 0.001. We conclude that using full mammogram images for breast cancer risk prediction captures additional information on breast tissue characteristics that relate to cancer risk, and improves prediction classification. This prediction algorithm can run efficiently in real time (in seconds) with processing of digital mammograms. Thus, this model can be easily implemented in mammography screening services and other clinical settings to guide real-time risk stratification to improve precision prevention of the leading cancer in women world-wide. Further analysis will quantify the value of adding other breast cancer risk factors, including polygenic risk scores. Addition of repeated mammogram images over time should further increase classification performance. This approach has the potential to improve risk classification by using data already available for the vast majority of women already having repeated screening mammograms. Citation Format: Shu Jiang, Graham A. Colditz. Whole mammogram image improves breast cancer prediction [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB161.
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Zhou, Silvia L., Sucy X. Wu, Jasmyn W. Ding, and Minica L. Liu. "Prof. Liyan Jiang: view respiratory medicine from a developmental perspective." Shanghai Chest 1 (2017): 26. http://dx.doi.org/10.21037/shc.2017.07.05.
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조문수. "A Study of the Aesthetical Ideas of Jiang Shi-Quan's Play." Journal of Chinese Cultural Studies ll, no. 23 (December 2013): 169–89. http://dx.doi.org/10.18212/cccs.2013..23.008.
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Yang, Benlong, Jiong Wu, Zhenzhen Liu, Hongjian Yang, Jinhai Tang, Kun Wang, Yunjiang Liu, et al. "Abstract P5-18-06: Proactive diarrhea management improved tolerability of pyrotinib in combination with trastuzumab and docetaxel in patients with HER2+ early or locally advanced breast cancer: Exploratory analysis from randomized, double-blind, phase 3 PHEDRA study." Cancer Research 82, no. 4_Supplement (February 15, 2022): P5–18–06—P5–18–06. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-18-06.
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Abstract Background: Diarrhea is a common side effect of many anti-cancer treatments, including chemotherapeutic agents, tyrosine kinase inhibitors, and pelvic radiotherapy. PHEDRA was a randomized, double-blind, multicenter, phase 3 study comparing the efficacy and safety of adding pyrotinib (an irreversible pan-ErbB inhibitor) to trastuzumab and docetaxel (pyrotinib arm) vs placebo, trastuzumab, and docetaxel (placebo arm) as neoadjuvant treatment in women with HER2+ early or locally advanced breast cancer (ClinicalTrials.gov: NCT03588091). We conducted this exploratory analysis to evaluate the effectiveness of proactive diarrhea management (PDM) according to the recommendation from independent data monitoring committee. Methods: Between July 23, 2018 and January 8, 2021, 355 patients were enrolled and randomized, of whom 212 and 143 patients were randomized before and after the implementation of PDM strategy. The diarrhea management strategy was strengthened with the early identification and proactive management of diarrhea, including use of loperamide as first choice of antidiarrheal agents and strict application of loperamide recommended dose (4 mg initially and an additional 2 mg following each diarrhea stool, not exceeding 16 mg/day). Primary prophylaxis with loperamide was not allowed. The incidence, severity, onset, and duration of diarrhea were summarized. The data cutoff date was April 30, 2021. Results: Of all 178 patients with pyrotinib arm, there were 43 (40.6%) and 56 (77.8%) patients applied loperamide as the first choice of antidiarrheal agents before and after the PDM implementation, respectively. The incidence of grade 3 diarrhea has decreased from 50.0% before the PDM implementation to 36.1% after the PDM implementation (Table 1). During neoadjuvant treatment period, grade 3 diarrhea mainly occurred during the first cycle of treatment for both treatment arms (C1: 20.8%), showing a sharp decreased trend during the following cycles (C2: 8.7%; C3: 5.4%; C4: 4.5%). Furthermore, among patients with pyrotinib arm, the incidences of grade 3 diarrhea in the first, second cycle and thereafter were lower in patients enrolled after the implementation of PDM than those enrolled before the PDM implementation (C1: 29.2%. vs 44.3%; C2: 10.1% vs 21.8%; C3: 7.2% vs 14.1%; C4: 4.5% vs 11.1%). Among patients with pyrotinib, compared with those enrolled before the PDM implementation, the median duration per diarrhea episode (4 days [IQR, 2-9] vs 2 days [1-5]), median duration per grade 3 diarrhea episode (2 days [IQR, 2-3] vs 2 days [1-2]), and median cumulative duration of grade 3 diarrhea (6 days [IQR, 3-9] vs 2 [2-5] days) were shortened in those enrolled after the PDM implementation. During neoadjuvant treatment period, 31 (17.4%) patients experienced diarrhea leading to pyrotinib dose reduction, and only 1 (0.6%) patient discontinued study treatment due to diarrhea in the pyrotinib arm. Conclusion: Pyrotinib tolerability was improved with PDM, which reduced the incidence and duration of grade 3 diarrhea. Grade 3 diarrhoea occurred mainly during the first cycle of treatment and reduced in the second cycle and thereafter. Diarrhea in the pyrotinib group was characterized by early onset and short duration and was generally manageable. Table 1.Characteristics of treatment-emergent diarrheaBEFORE the implementation of PDMAFTER the implementation of PDMPyrotinib+Trastuzumab+Docetaxel(N=106)Placebo+Trastuzumab+Docetaxel(N=106)Pyrotinib+Trastuzumab+Docetaxel(N=72)Placebo+Trastuzumab+Docetaxel(N=71)Diarrhea incidence, n (%)All grade106 (100.0)57 (53.8)72 (100.0)36 (50.7)Grade 112 (11.3)32 (30.2)7 (9.7)28 (39.4)Grade 241 (38.7)18 (17.0)39 (54.2)6 (8.5)Grade 353 (50.0)7 (6.6)26 (36.1)2 (2.8)Cycle 147 (44.3)4 (3.8)21 (29.2)2 (2.8)Cycle 222 (21.8)2 (1.9)7 (10.1)0Cycle 314 (14.1)05 (7.2)0Cycle 411 (11.1)2 (1.9)3 (4.5)0Grade 4 or 50000Median time to the first onset, days (IQR)All grade4 (2 to 5)7 (4 to 28)3 (2 to 4)6 (5 to 12)Grade 39 (5 to 11)16 (7 to 24)9 (6 to 12)11 (6 to 16)Median duration per diarrhea episode, days (IQR)All grade4 (2 to 9)2 (2 to 4)2 (1 to 5)2 (1 to 3)Grade 32 (2 to 3)2 (2 to 2)2 (1 to 2)1 (1 to 1)Median cumulative duration, days (IQR)Grade 36 (3 to 9)2 (2 to 3)2 (2 to 5)1 (1 to 1)Median time since the first onset to recovery, days (IQR)All grade7 (3 to 12)2 (2 to 4)3 (1 to 10)2 (1 to 4)Note: PDM, proactive diarrhea management; IQR, interquartile range. Citation Format: Benlong Yang, Jiong Wu, Zhenzhen Liu, Hongjian Yang, Jinhai Tang, Kun Wang, Yunjiang Liu, Haibo Wang, Peifen Fu, Shuqun Zhang, Qiang Liu, Zefei Jiang, Shusen Wang, Jian Huang, Chuan Wang, Shu Wang, Yongsheng Wang, Linlin Zhen, Fei Wu, Shulin Liu, Xiang Lin, Jianjun Zou. Proactive diarrhea management improved tolerability of pyrotinib in combination with trastuzumab and docetaxel in patients with HER2+ early or locally advanced breast cancer: Exploratory analysis from randomized, double-blind, phase 3 PHEDRA study [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P5-18-06.
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Lee, Geun Myung. "Wang An-shi in the Period of the Retirement in Jiang-ning." CHUNGGUKSA YONGU (The Journal of Chinese Historical Researches) 116 (October 31, 2018): 111–32. http://dx.doi.org/10.24161/chr.116.111.
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Sargent, Stuart, and Mo Li-feng. "Chiang-hsi shih-p'ai yen-chiu (Jiang xi shi pai yan jiu)." Chinese Literature: Essays, Articles, Reviews (CLEAR) 9, no. 1/2 (July 1987): 151. http://dx.doi.org/10.2307/495294.
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Shen, Xingchen, and Xinren Chen. "Doing Power Threatening Acts (PTAs) in ancient China." Journal of Historical Pragmatics 20, no. 1 (June 4, 2019): 132–56. http://dx.doi.org/10.1075/jhp.17002.she.
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Abstract This study examines an unexplored type of speech act named jian, which took place uniquely in the context of ancient China. Taking it as a Power Threatening Act rather than a commonly studied Face Threatening Act, this study examined remonstrators’ strategic modulation of their jian, and the factors that might have influenced the choice of modulation strategies. The data come from Zizhi Tongjian. The major findings are as follows: first, the speech act of jian contained both ritualised and non-ritualised aspects; second, remonstrators would adopt different modulation strategies when performing jian, which can be generally divided into three modulation orientations of redress, aggravation, and a combination of redress and aggravation, with different degrees of rituality; third, the choices of modulation strategies reflected the game playing of the requirements of affiliational propriety and illocutionary effect within the jian act.
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Xiao-bing, Zhao, and Zhao Wenqing. "About the Chinese Book “The Book of Poetry”." Humanitarian Vector 16, no. 1 (February 2021): 25–34. http://dx.doi.org/10.21209/1996-7853-2021-16-1-25-34.
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“The Shi Jing’’(‘‘The Book of Poetry”） is one of the first poems in the world, including Chinese poems, from the 11th century BC to the 6th century BC. During this period, about 3 000 verses appeared, of which 305 poems were selected by Confucius. Poetic texts in “The Shi Jing’are divided into three categories: regional songs, odes, hymns. The composition of the poems uses such techniques as Fu, Bi and Xing. These poems constitute the creative source (source) of Chinese poetry. “Fu”，“Bi” and “Xing” are important artistic features of “The Shi Jing”. “Fu”” - direct narration, parallelism. “Bi” is a metaphor, comparison. “Sin” means “stimulation”， it first speaks about others, then about what the poet wants to express. Fu and Bi are the most basic techniques of expression, and Xing is a relatively unique technique in “The Shi Jing”， even in Chinese poetry in general. “The Shi Jing” is an excellent starting point for Chinese literature, which has already reached a very high artistic level from the very beginning. "The Shi Jing” affects almost all aspects of the early social life of ancient China, such as sacrifice, banquet, labor, war, love, marriage, corvee, animals, plants, oppression and resistance, manners and customs, even astronomical phenomena, etc. It became historical value for the study of that society. The overwhelming majority of the poems in “The Shi Jing”reflect the reality, everyday life and everyday experience. There is almost no illusory and supernatural mythical world in it. As the first collection of poetry in China, “The Shi Jing” laid the foundation for the lyrical and realistic tradition of Chinese literature. “The Shi Jing” also has a huge impact on the genre structure and linguistic art of Chinese literature, etc., which is a role model for writers of later generations. “The Shi Jing”has already been translated into the languages of the countries of the world. “The Shi Jing”has been influencing Chinese poetics; it has become the source of the classical realistic tradition and literature in China. Lively description is essential for historical, anthropological and sociological research. We expect that as the cultural ties between China and Russia deepen, as well as the popularization and spread of Chinese-Russian translations, more and more Russian people will read “The Shi Jing”， study “The Shi Jing”， the Russian translation of “The Shi Jing” will improve and play its role as the original classic of Chinese literature. “The Shi Jing”is a book that cannot be read or translated forever. Keywords: “The Shi Jing” （“The Book of Poetry” )， regional songs, odes, hymns, artistic features, Chinese unique cultural value
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黃罄慧, 黃罄慧. "1999-2019年宜蘭縣人口成長和產業結構轉變與北宜高速公路之關聯." 國立彰化師範大學文學院學報 26, no. 26 (November 2022): 019–44. http://dx.doi.org/10.53106/230597612022110026002.
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<p>本文主要目的為探討1999-2019年間宜蘭縣人口、產業、地價之變化與2006年通車的北宜高速公路之關聯。採用政府部門統計資料，分析人口之自然增加、社會增加判斷20年間人口成長與空間分布的變化趨勢，並透過區位商數解釋產業結構的變遷，以及由都市地價的變動探討各鄉鎮市發展的消長狀況。 研究發現1999-2019年間宜蘭縣受到少子化、高齡化的影響使得人口自然增加率為負成長的趨勢；北宜高速公路通車減緩人口外移的趨勢帶來「時空收斂」的效果，宜蘭縣內部的人口分布也趨於分散符合了Friedmann「空間發展階段」中成熟階段所提及的平衡都市體系。產業結構雖沒有出現明顯的變化，但在行業別中以區位商數計算出「運輸、倉儲及通訊業」、「住宿及餐飲業」、「不動產業及租賃業」這三種行業在北宜高速公路通車後有明顯變動，尤其是「運輸、倉儲及通訊業」、「住宿及餐飲業」為穩定的發展，可以判斷對觀光相關產業有深遠影響。都市地價指數則呈現先下後上，依其變化趨勢劃分為三個階段：1998-2004年通車前黑暗期、2005-2013通車觀察期、2014-2019穩定成長期，但並非雨露均霑，其中以觀光業最發達的礁溪鄉成長最為顯著。</p> <p> </p><p>The main purpose of this study is to discuss the relationship between the changes in Yilan County’s population, industrial structure, and land prices and the Jiang Wei-shui Freeway from 1999 to 2019. This study uses the statistical data of government departments to analyze the natural increase and social increase of population, and to distinguish the changing trend of population growth and spatial distribution in the past 20 years. This study explains the changes in industrial structure through LQ(location quotient), and then discusses the change of land price in each township. The study found that from 1999 to 2019, negative trend of natural population growth rate in Yilan County was affected by the declining birthrate and aging population. Jiang Wei-shui Freeway slows down the trend of population outflow, and brings the effect of ""space-time convergence"". The population distribution within Yilan County also tends to disperse, in line with the balanced urban system mentioned in Friedmann’s ""Space Development Stage"" in the mature stage. There have been obvious changes in tertiary industry of ""transportation, storage and communications"", ""accommodation and food service activities"", and ""real estate and leasing activities"" calculated by LQ. Especially, ""transportation, storage and communications"", ""accommodation and food service activities"" have developed steadily, which can be determine to have a profound effect on tourism-related industries. The urban land price index showed first down then up. It can be divided into three stages: the dark period before the opening to traffic in 1998-2004, the observation period of opening to traffic in 2005-2013, and the stable growth period in 2014-2019. And it is not equally allocation in Yilan County, Jiaoxi Township which has the most developed tourism industry, has the most significant growth.</p> <p> </p>
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Huang (黄德寬), Dekuan. "A Brief Description of the Anhui University Shi Jing Manuscript." Bamboo and Silk 4, no. 2 (September 1, 2021): 233–45. http://dx.doi.org/10.1163/24689246-00402010.
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Abstract In 2015, Anhui University acquired a valuable batch of bamboo manuscripts from the Warring States period. The Anda slips have received wide attention both abroad and in China, in particular the Shi jing manuscript contained therein. This article discusses the sequence, number, and variants of the songs, titles, wording, and phrasing in the Shi jing manuscript. The final section of this article introduces the philological value of this find.
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KAIYUAN, ZHANG. "Hu Shi, Zhang Jian, and Zhang Jian's Son." Chinese Studies in History 38, no. 1 (October 2004): 66–76. http://dx.doi.org/10.1080/00094633.2004.11039489.
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He, Min, Benlong Yang, Jiong Wu, Zhenzhen Liu, Hongjian Yang, Jinhai Tang, Kun Wang, et al. "Abstract P5-18-10: Mecapegfilgrastim for primary prophylaxis of neutropenia in 355 HER2+ breast cancer patients treated with neoadjuvant docetaxel in combination with trastuzumab and/or pyrotinib: Exploratory analysis from randomized, double-blind, phase 3 PHEDRA study." Cancer Research 82, no. 4_Supplement (February 15, 2022): P5–18–10—P5–18–10. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-18-10.
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Abstract Background: A dose relationship may exist for both antitumor activity and toxicity of docetaxel in breast cancer (BC) patients, while 86% grade 4 neutropenia and 12% febrile neutropenia (FN) were reported when pretreated advanced breast cancer (ABC) patients received 100 mg/m2 docetaxel monotherapy without hematopoietic support. PHEDRA was a randomized, double-blind, multicenter, phase 3 study comparing the efficacy and safety of adding pyrotinib to trastuzumab and docetaxel as neoadjuvant treatment in women with HER2+ early or locally ABC (ClinicalTrials.gov: NCT03588091). We conducted this exploratory analysis to evaluate the effectiveness of mecapegfilgrastim, a long-acting recombinant human granulocyte colony-stimulating factor (rhG-CSF), as primary prophylaxis for neoadjuvant chemotherapy-induced neutropenia in BC patients. Methods: Patients with HER2-positive early or locally ABC were randomly assigned (1:1) to pyrotinib arm receiving 4 neoadjuvant cycles of docetaxel (100 mg/m2 iv d1 q3w), trastuzumab (8 mg/kg iv, cycle 1 d1, then 6 mg/kg d1 q3w), and pyrotinib (400 mg po qd, d1-21, q3w) or placebo arm with placebo, trastuzumab and docetaxel. Per protocol, patients were required to receive a single, 6-mg fixed dose of mecapegfilgrastim on Day 2 of each cycle. Other G-CSF was permitted if mecapegfilgrastim was unavailable at the local center or patients occurred mecapegfilgrastim intolerance. The incidence of neutropenia, FN, time to first neutropenia onset, duration per neutropenia event and cumulative neutropenia duration during neoadjuvant treatment period; and the incidences of grade 3/4 neutropenia, FN and decreased WBC count in Cycle 1 to 4 (C1-4) were presented. The data cutoff date was April 30, 2021. Results: Between July 23, 2018 and January 8, 2021, 355 patients were randomized (pyrotinib arm, n=178; placebo arm, n=177). Among them, 291 (82.0%) patients received a single, 6-mg fixed dose of mecapegfilgrastim in Cycle 1 and 270 (76.1%) patients received mecapegfilgrastim in each of the 4 cycles. Grade 3/4 neutropenia was reported in 33 (18.5%) patients in the pyrotinib arm and 36 (20.3%) patients in the placebo arm. Five (2.8%) patients in the pyrotinib arm and 2 (1.1%) patients in the placebo arm developed FN (5 FN occurred in C1; 2 FN occurred in C2). Median duration of grade 3/4 neutropenia was 3 days in the pyrotinib group and 3 days in the placebo group. Median cumulative duration of grade 3/4 neutropenia was 4 days and 3 days in the pyrotinib group and the placebo group, respectively. Grade 3/4 neutropenia mainly occurred during the first cycle of treatment for both pyrotinib (13.5%) and placebo arm (15.8%), reduced in the second cycle (5.9% vs 4.0%) and thereafter (C3: 1.8% vs 3.4%; C4: 2.4% vs 1.7%). Similar trends were observed for grade 3/4 WBC count decreased in Cycle 1 to 4. No grade 4 infection occurred. Overview of neutropenia, FN and WBC count decreased was summarized in Table 1. Consistent findings were observed in 291 mecapegfilgrastim treated patients. Conclusion: The exploratory analysis demonstrated 6-mg fixed dose of mecapegfilgrastim was effective when administrated as primary prophylaxis for neoadjuvant chemotherapy-induced neutropenia, which could be considered as a new treatment option for its advantage of once-per-cycle dosing and convenient dose management. Table 1.Overview of neutropenia, febrile neutropenia and WBC count decrease during neoadjuvant treatment period.Docetaxel+Trastuzumab+Pyrotinib(N=178)Docetaxel+Trastuzumab+Placebo (N=177)All randomized patients(N=355)Neutropenia, n (%)Any grade57 (32.0)54 (30.5)111 (31.3)Grade 16 (3.4)5 (2.8)11 (3.1)Grade 218 (10.1)13 (7.3)31 (8.7)Grade 315 (8.4)20 (11.3)35 (9.9)Grade 418 (10.1)16 (9.0)34 (9.6)Median time to first onset (IQR), days7 (6-63)6 (6-49)7 (6-53)Median duration per grade 3 or higher neutropenia, days (range)3 (1-16)3 (2-12)3 (1-16)Median cumulative duration of grade 3 or higher neutropenia, days (range)4 (2-16)3 (2-14)3 (2-16)FN, n (%)5 (2.8)2 (1.1)7 (2.0)Grade 3 or higher neutropenia, n (%) *Cycle 124 (13.5)28 (15.8)52 (14.6)Cycle 210 (5.9)7 (4.0)17 (4.9)Cycle 33 (1.8)6 (3.4)9 (2.6)Cycle 44 (2.4)3 (1.7)7 (2.1)Grade 3 or higher FN, n (%) *Cycle 12 (1.1)2 (1.1)4 (1.1)Cycle 22 (1.2)02 (0.6)Cycle 3000Cycle 4000Grade 3 or higher WBC count decreased, n (%) *Cycle 120 (11.2)20 (11.3)40 (11.3)Cycle 28 (4.7)2 (1.1)10 (2.9)Cycle 32 (1.2)1 (0.6)3 (0.9)Cycle 44 (2.4)2 (1.1)6 (1.8)Note: IQR, interquartile range; FN, febrile neutropenia; WBC, white blood cell.*The denominator indicates number of patients with mecapegfilgrastim for prophylaxis use in this cycle. Citation Format: Min He, Benlong Yang, Jiong Wu, Zhenzhen Liu, Hongjian Yang, Jinhai Tang, Kun Wang, Yunjiang Liu, Haibo Wang, Peifen Fu, Shuqun Zhang, Qiang Liu, Zefei Jiang, Shusen Wang, Jian Huang, Chuan Wang, Shu Wang, Yongsheng Wang, Linlin Zhen, Xiaoyu Zhu, Shulin Liu, Ping Yan, Jianjun Zou. Mecapegfilgrastim for primary prophylaxis of neutropenia in 355 HER2+ breast cancer patients treated with neoadjuvant docetaxel in combination with trastuzumab and/or pyrotinib: Exploratory analysis from randomized, double-blind, phase 3 PHEDRA study [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P5-18-10.
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Allan, Sarah. "On Shu 書 (Documents) and the origin of the Shang shu 尚書 (Ancient Documents) in light of recently discovered bamboo slip manuscripts." Bulletin of the School of Oriental and African Studies 75, no. 3 (October 2012): 547–57. http://dx.doi.org/10.1017/s0041977x12000547.
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AbstractIn light of the recent discovery of Warring States period bamboo slips, now in the collection of Tsinghua University, inscribed with texts described as shu, “documents” or “similar to shu”, this article explores the question of “what were shu?” It suggests that shu can be understood as a literary form apart from the history of the Confucian classic, the Shang shu 尚書 (Ancient Documents) or Shu jing 書經 (Book of Documents) and the Yi Zhou shu 逸周書. Formal characteristics include: shu were – or pretended to be – contemporaneous records; and shu include formal speeches by model kings and ministers from ancient times. Many shu include the expression wang ruo yue 王若曰, which is also found in bronze inscriptions, where it indicates that a royal speech was read aloud by an official. Thus, the literary form originated with the practice of composing speeches in writing before they were read out in formal ceremonies, with a bamboo slip copy presented to the officials addressed. Later shu were fictional compositions, written in the style of these ancient documents.
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Strand, Siri H., Belén Rivero-Gutiérrez, Kathleen E. Houlahan, Jose A. Seoane, Lorraine M. King, Tyler Risom, Lunden Simpson, et al. "Abstract GS4-07: The Breast PreCancer Atlas DCIS genomic signatures define biology and correlate with clinical outcomes: An analysis of TBCRC 038 and RAHBT cohorts." Cancer Research 82, no. 4_Supplement (February 15, 2022): GS4–07—GS4–07. http://dx.doi.org/10.1158/1538-7445.sabcs21-gs4-07.
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Abstract Background. DCIS consists of a molecularly heterogeneous group of premalignant lesions, with variable risk of invasive progression. Understanding biomarkers for invasive progression could help individualize treatment recommendations based upon tumor biology. As part of the NCI Human Tumor Atlas Network (HTAN), we conducted comprehensive genomic analyses on two large DCIS case-control cohorts. Methods. We performed smart3-seq and low-pass whole genome sequencing on two independent, retrospective, longitudinally sampled DCIS case-control cohorts. TBCRC 038 was a multicenter cohort diagnosed with DCIS between 1998 and 2016 at one of the Translational Breast Cancer Research sites; the RAHBT (Resource of Archival Human Breast Tissue) cohort included women identified through the St. Louis Breast Tissue Repository, and the Women’s Health Repository diagnosed between 1997 and 2001. We studied the spectrum of molecular changes present and sought genomic predictors of subsequent ipsilateral breast events (iBEs: DCIS recurrence or invasive progression) in both DCIS epithelium and stroma in formalin fixed paraffin embedded tissue. We generated de novo tumor and stroma-centric subtypes for DCIS that represents fundamental transcriptomic organization. Copy number analysis was performed using low-pass DNA sequencing. Non-negative matrix factorization (NMF) was applied to the RNA expression of all coding genes to identify clusters. A negative-binomial regression model was used to identify differentially expressed genes. Results. We analyzed 677 DCIS samples from 481 patients with 7.1 years median follow-up. In TBCRC samples, we identified three clusters via NMF in TBCRC referred to as ER low, quiescent, and ER high. The ER-low cluster had significantly higher levels of ERBB2 and lower levels of ESR1 compared to quiescent and ER-high clusters. Quiescent cluster lesions were less proliferative and less metabolically active than ER high and ER low subtypes. These findings were replicated in the RAHBT cohort. Focusing on the stromal component of DCIS from laser capture microdissection in RAHBT samples, we identified four distinct DCIS-associated stromal clusters. A “normal-like” stromal cluster with ECM organization and PI3K-AKT signaling; a “collagen-rich” stromal cluster; a “desmoplastic” stromal cluster with high fibroblast and total myeloid abundance, mostly associated with macrophages and myeloid dendritic cells (mDC); and an “immune-dense” stromal cluster. Further, we compared differentially expressed genes in patients with or without subsequent iBEs within 5 years of diagnosis. Hypothesizing that the resulting 812 DE genes (DESeq2) represent multiple routes to subsequent iBEs, we leveraged NMF to identify paths to progression. In both TBCRC and RAHBT cohorts, poor outcome groups exhibited increased ER, MYC signaling, and oxidative phosphorylation, supporting that these pathways are important for DCIS recurrence and progression. Conclusion. Comprehensive genomic profiling in two independent DCIS cohorts with longitudinal outcomes shows distinct DCIS stromal expression patterns and immune cell composition. RNA expression profiles reveal underlying tumor biology that is associated with later iBEs in both cohorts. These studies provide new insight into DCIS biology and will guide the design of diagnostic strategies to prevent invasive progression. Citation Format: Siri H Strand, Belén Rivero-Gutiérrez, Kathleen E Houlahan, Jose A Seoane, Lorraine M King, Tyler Risom, Lunden Simpson, Sujay Vennam, Aziz Khan, Timothy Hardman, Bryan E Harmon, Fergus J Couch, Kristalyn Gallagher, Mark Kilgore, Shi Wei, Angela DeMichele, Tari King, Priscilla F McAuliffe, Julie Nangia, Joanna Lee, Jennifer Tseng, Anna Maria Storniolo, Alastair Thompson, Gaorav Gupta, Robyn Burns, Deborah J Veis, Katherine DeSchryver, Chunfang Zhu, Magdalena Matusiak, Jason Wang, Shirley X Zhu, Jen Tappenden, Daisy Yi Ding, Dadong Zhang, Jingqin Luo, Shu Jiang, Sushama Varma, Cody Straub, Sucheta Srivastava, Christina Curtis, Rob Tibshirani, Robert Michael Angelo, Allison Hall, Kouros Owzar, Kornelia Polyak, Carlo Maley, Jeffrey R Marks, Graham A Colditz, E Shelley Hwang, Robert B West. The Breast PreCancer Atlas DCIS genomic signatures define biology and correlate with clinical outcomes: An analysis of TBCRC 038 and RAHBT cohorts [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr GS4-07.
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Kanai, Shigeyuki, Norimasa Taniguchi, and Hideaki Higashino. "Study of Sokei-Kakketu-To (Shu-Jing-Huo-Xue-Tang) in Adjuvant Arthritis Rats." American Journal of Chinese Medicine 31, no. 06 (January 2003): 879–84. http://dx.doi.org/10.1142/s0192415x03001600.
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To examine the effectiveness of the herbal medicine prescription, Shu-Jing-Huo-Xue-Tang (SJHXT), for pain relief, we performed a study using rats with adjuvant arthritis (AA). After injecting the adjuvant, AA rats were maintained for 6 months as a chronic pain model. Starting at 6 months, SJHXT was administered for 12 weeks. We measured the tail skin temperature and locomotor activity of rats using thermography and a metabolism measuring system, respectively, before and after 12 weeks of SJHXT administration. Normal rats were used as controls. Before SJHXT administration, the tail surface temperature and locomotor activity were significantly lower in the AA rats than in the control rats. The tail skin temperature and locomotor activity of SJHXT-treated AA rats were significantly higher than those of the control rats. These findings suggest that the pain relief effects of SJHXT may be primarily due to increased blood circulation.
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CHO, Sein. "On the Textual Versions of the Amituo jing shu Attributed to Ji." Journal of Indian and Buddhist Studies (Indogaku Bukkyogaku Kenkyu) 65, no. 1 (2016): 509–6. http://dx.doi.org/10.4259/ibk.65.1_509.
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HUNG, Hung-lung. "The Newly Found Kongo-Ji Manuscript An-Ban Shou-Yi Jing and T602 Fo-Shuo Da An-Ban Shou-Yi Jing." JOURNAL OF INDIAN AND BUDDHIST STUDIES (INDOGAKU BUKKYOGAKU KENKYU) 54, no. 3 (2006): 1226–31. http://dx.doi.org/10.4259/ibk.54.1226.
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Lin, Shu, Haohan Tan, Qihong Liu, Yunling Wang, Bin Liu, Zhifu Li, Zhifang Chen, et al. "Abstract 5438: FCN-589, a novel, potent and selective BTK inhibitor, targets BTK C481S for the treatment of B-cell malignancies." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5438. http://dx.doi.org/10.1158/1538-7445.am2022-5438.
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Abstract Bruton’s tyrosine kinase (BTK) is a member of the Tec family of non-receptor tyrosine kinases and plays critical roles in B-cell receptor (BCR) signaling. BTK is often overexpressed in B-cells of patients with hematological malignancies. BTK inhibition blocks BCR signals, prevents B-cell activation and malignant B-cell growth, and induces apoptosis. Early irreversible BTK inhibitors such as ibrutinib, which covalently binds to the cysteine residue (C481) of BTK, are effective against B-cell malignancies and have received approval for various B-cell lymphomas and leukemia including mantle cell lymphoma and chronic lymphocytic leukemia, but their effectiveness is often limited by toxicities from off-target inhibition of the Tec (e.g., ITK/TEC) and EGFR family (e.g., EGFR/HER2/HER4). Acquired resistance mutations in the C481 binding site are known to cause clinical resistance to irreversible BTK inhibitors, which accounts for over half of progression in patients received ibrutinib. There is thus unmet medical need for a novel BTK inhibitor with improved safety profile efficacious against C481 mutation. Here we introduce FCN-589, a novel and orally active next-generation BTK inhibitor. FCN-589 shows potent kinase activities against wild-type (WT) BTK and the most common resistant mutation BTK C481S with single-digit nanomolar IC50 and improved selectivity over clinically significant off-targets such as TRK and ITK compared with nemtabrutinib (MK-1026, ARQ 531), another BTK C481S inhibitor in development. FCN-589 exhibits remarkable anti-proliferating potency against a panel of human B-cell malignancies-derived cancer cell lines. FCN-589 is over 30x more potent against follicular lymphoma cells (DOHH2) and activated B-cell subset of diffuse large B-cell lymphoma (DLBCL) cells (OCI-LY10 and Ri-1), and about 4x more potent against germinal center B-cell like subset of DLBCL cells (SU-DHL-4) compared with ARQ 531. In HEK-293 cell line ectopically expressing WT or BTK C481S, FCN-589 markedly inhibits p-BTK expression with superior activity compared with ARQ 531. Consistently, FCN-589 shows significant and superior anti-tumor activities in mice xenograft models derived from human non-Hodgkin’s lymphomas compared with ARQ 531 and ibrutinib. In non-clinical studies, FCN-589 exhibits good pharmacokinetic (PK) and safety properties. In particular, FCN-589 has longer T1/2 in both rats and dogs, displays improved CYP450 inhibition profile, and is less plasma protein bound compared with ARQ 531. Overall, FCN-589 is a novel next-generation BTK inhibitor targeting WT and BTK C481S. FCN-589 possesses potent in vitro and in vivo anti-cancer activities with better selectivity against clinically significant off-targets and exhibits favorable PK and safety profiles compared with ARQ 531. FCN-589 has potential to be a more effective and safer option for patients with B-cell malignancies. Citation Format: Shu Lin, Haohan Tan, Qihong Liu, Yunling Wang, Bin Liu, Zhifu Li, Zhifang Chen, Xianlong Wang, Xingdong Zhao, Lihua Jiang, Xilei Wang, Tao Cheng, Jiashu Zhou, Weibo Wang. FCN-589, a novel, potent and selective BTK inhibitor, targets BTK C481S for the treatment of B-cell malignancies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5438.
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Park, Yikyung, Mei Wang, Tuo Lan, AnnaLynn M. Williams, Matthew J. Ehrhardt, Emily R. Finch, Jennifer Q. Lanctot, et al. "Abstract A019: Cancer survivor-specific dietary patterns and risk of premature aging in adult survivors of childhood cancer: St. Jude Lifetime (SJLIFE) Cohort." Cancer Research 83, no. 2_Supplement_1 (January 15, 2023): A019. http://dx.doi.org/10.1158/1538-7445.agca22-a019.
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Abstract Background: Childhood cancer survivors are a growing population at elevated risk for premature aging and age-related chronic health conditions (CHCs) compared to the general population. In the general population, diet affects many hallmarks of aging, including inflammation, metabolic dysfunctions, and molecular and epigenetic changes. We examined associations between dietary patterns and risk of premature aging in adult survivors of childhood cancer. Methods: Adult survivors (18-65 years old, mean [SD] age 31 [8.4] years) of childhood cancer enrolled in SJLIFE between 2007 and 2017 completed a 110-item food frequency questionnaire at enrollment (n=2,904). Sociodemographic, cancer, cancer treatments, and health history were abstracted from medical records; CHCs were clinically validated. Factor analysis was performed to identify dietary patterns specific to the study population. Premature aging was assessed using the Deficit Accumulation Index (DAI) based on 45 age-related CHCs and categorized into low (<0.2), medium (0.2-0.34), and high (>0.35) aging risk groups. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multinomial logistic regressions adjusting for potential confounders, such as sociodemographics, health behaviors, and cancer treatments. Individuals’ factor scores of each pattern were grouped into quintiles, and a median score of each quintile was entered as a continuous term in regression models. Results: 20% of survivors were at medium- and 8% were at high-risk for premature aging. Survivors at high-risk for premature aging were more likely to be female, smokers, have low socioeconomic status, and have received radiation therapy to head and neck, chest, spine, or abdomen compared to those at low premature aging risk. Three dietary patterns were identified: 1) plant-based, 2) fast-food, and 3) Western contemporary. A plant-based diet was characterized by greater intakes of vegetables, fruits, whole grains, and fish. A higher plant-based diet pattern score was associated with a lower risk of premature aging (OR=0.76, 95% CI: 0.62-0.94 for the high-risk group; OR=0.91, 95% CI: 0.79-1.04 for the medium-risk group). A fast-food diet was characterized by greater intakes of sweets, processed meat, refined grains, potato, high-fat dairy, and soda. A fast-food diet was related to a non-significant increased risk of premature aging (OR=1.20, 95% CI: 0.91-1.57 for the high-risk group; OR=1.18, 95% CI: 0.98-1.43 for the medium-risk group). A Western contemporary diet characterized by greater intakes of meat, pasta/rice, pizza, Mexican food, and fruit juice was associated with an increased risk of premature aging (OR=1.36, 95% CI: 1.05-1.78 for the high-risk group; OR=1.04, 95% CI: 0.87-1.26 for the medium-risk group). Conclusion: Our findings suggest that diet plays a role in aging, and a diet rich in plant-based foods may mitigate the risk of premature aging in childhood cancer survivors. Citation Format: Yikyung Park, Mei Wang, Tuo Lan, AnnaLynn M. Williams, Matthew J. Ehrhardt, Emily R. Finch, Jennifer Q. Lanctot, Shu Jiang, Kevin R. Krull, Gregory T. Armstrong, Melissa M. Hudson, Graham A. Colditz, Leslie Robison, Kirsten K. Ness. Cancer survivor-specific dietary patterns and risk of premature aging in adult survivors of childhood cancer: St. Jude Lifetime (SJLIFE) Cohort [abstract]. In: Proceedings of the AACR Special Conference: Aging and Cancer; 2022 Nov 17-20; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_1):Abstract nr A019.
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Lan, Tuo, Mei Wang, AnnaLynn M. Williams, Matthew J. Ehrhardt, Emily R. Finch, Jennifer Q. Lanctot, Shu Jiang, et al. "Abstract PR014: Sugar Intake and premature aging in adult survivors of childhood cancer in the St. Jude Lifetime (SJLIFE) Cohort." Cancer Research 83, no. 2_Supplement_1 (January 15, 2023): PR014. http://dx.doi.org/10.1158/1538-7445.agca22-pr014.
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Abstract Background: In the general population, sugar intake is associated with a wide range of adverse health conditions related to premature aging, including obesity, diabetes, and cardiovascular disease. Childhood cancer survivors are at increased risk of premature aging and mortality compared to their healthy peers and may be especially vulnerable to adverse consequences of excess sugar intake. Objective: To examine the association between sugar and sugar-sweetened beverage intake and premature aging in childhood cancer survivors. Method: A total of 3,322 adult survivors of childhood cancer (age range 18-65 years; mean age: 31 years) in SJLIFE self-reported their typical diet using the 110-item Block Food Frequency Questionnaire. Added sugars included all sugars added to foods during preparation or processing. Total sugar-sweetened beverages are the sum of regular and diet soda and fruit-flavored drinks. Survivors’ sociodemographics, cancer histories, and health conditions were abstracted from medical records. Premature aging was assessed using the Deficit Accumulation Index (DAI) that was a ratio of the number of age-related chronic health conditions each survivor had out of 45 conditions total. The DAI was categorized into low (<0.2), medium (0.2-0.34), and high (>0.35) aging risk groups. Multinomial logistic regressions (reference: low aging risk group) adjusting for confounders, including sociodemographics, lifestyle factors, cancer treatments, and overall diet quality, were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Survivors’ average total sugar intake was 120 g/day and added sugar intake was 71 g/day. 41% of survivors consumed sugar-sweetened beverages ≥1 time/day, and 26% consumed soda daily; 75% of soda consumed was regular (vs. diet). Survivors with higher consumption of sugar and sugar-sweetened beverages were more likely to be non-Hispanic Black and have lower educational attainment and income. Total sugar intake was associated with a significantly increased risk of premature aging (per 25 g/1,000 kcal increment, OR=1.31 [95% CI: 1.00-1.70] in the medium-risk group; OR=1.52 [95% CI: 1.03-2.25] in the high-risk group). Added sugar intake was associated with a 19% (OR=1.19, 95% CI: 1.07-1.31, per 20 g/1,000 kcal increment) and an 18% (OR=1.18, 95% CI: 1.02-1.37) increased risk of premature aging in the medium- and high-risk group, respectively. Consuming ≥2 servings/day (vs. ≤ 1/week) of total sugar-sweetened beverage was also related to an increased risk of premature aging (OR=1.54 [95% CI: 0.83-2.83] in the medium-risk group; OR=6.71 [95% CI: 2.95-15.2] in the high-risk group). Regular soda, but not diet soda, consumption was associated with premature aging risk. Conclusion: Higher consumption of sugar and sugar-sweetened beverages was associated with an increased risk of premature aging in childhood cancer survivors. Intervention efforts to reduce sugar intake among this vulnerable population are needed. Citation Format: Tuo Lan, Mei Wang, AnnaLynn M. Williams, Matthew J. Ehrhardt, Emily R. Finch, Jennifer Q. Lanctot, Shu Jiang, Kevin R. Krull, Gregory T. Armstrong, Melissa M. Hudson, Graham A. Colditz, Leslie Robison, Kirsten K. Ness, Yikyung Park. Sugar Intake and premature aging in adult survivors of childhood cancer in the St. Jude Lifetime (SJLIFE) Cohort [abstract]. In: Proceedings of the AACR Special Conference: Aging and Cancer; 2022 Nov 17-20; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_1):Abstract nr PR014.