Log in

Relevant bibliographies by topics / Dumbrava / Journal articles

To see the other types of publications on this topic, follow the link: Dumbrava.

Journal articles on the topic 'Dumbrava'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Dumbrava.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Diaconescu, Petre, and Gabriel Mihăescu. "Cercetări arheologice la Dumbrava, com. Ulmi, jud. Dîmboviţa / Recherches archéologiques à Dumbrava, com. d'Ulmi dép. de Dîmboviţa." Materiale şi cercetări arheologice 16, no. 1 (1986): 253–61. http://dx.doi.org/10.3406/mcarh.1986.1904.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

ȘENDRESCU, Ramona, and Georgeta Amelia MOTOI. "Adjective cromatice și epitete cromatice în Dumbrava minunată." ANALELE UNIVERSITĂȚII DIN CRAIOVA SERIA ȘTIINȚE FILOLOGICE LIMBI STRĂINE APLICATE 2023, no. 1 (2023): 288–95. http://dx.doi.org/10.52744/aucsflsa.2023.01.27.

Full text

Abstract:

Our article, “Use of chromatic adjectives and chromatic epithets in The Wonderful Grove story” examines the way in which qualifying adjectives reflect Mihail Sadoveanu’s subjectivity in this literary piece. We aim at identifying, classifying and analyzing the most frequently used qualifying adjectives in this story, namely the adjectives of colour. The epithet is the most significant stylistic figure of the adjective of colour. The chromatic adjectival semantics are wide and varied in The Wonderful Grove story. The chromatic epithet was used for descriptive and visual purposes; in this case, w

APA, Harvard, Vancouver, ISO, and other styles

3

Sredanovic, Djordje. "Nationality, Citizenship and Ethno-Cultural Belonging, written by Costica Dumbrava." European Journal of Migration and Law 17, no. 4 (2015): 395–98. http://dx.doi.org/10.1163/15718166-12342087.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Ghergari, Lucreția, Corina Ionescu, and Cristina Mariș. "Date noi privind compozitia mineralogica a siltului lutitic de la Dumbrava, judetul Cluj (New Mineralogical Data on the Clayey Silt from Dumbrava (Cluj County)." Studia Universitatis Babes-Bolyai, Geologia 45, no. 1 (2000): 23–34. http://dx.doi.org/10.5038/1937-8602.45.1.2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

A., Krizaa, Reiss A., Muresan V., and Florea S. "Complex compounds of ions with d8 and d10 electronic configuration with a new thioamide of the dibenzofuran series." Journal of Indian Chemical Society Vol. 76, Aug 1999 (1999): 406–7. https://doi.org/10.5281/zenodo.5852039.

Full text

Abstract:

Faculty of Chemistry, University of Bucharest, Dumbrava Rosie, 23, Romania Faculty of Sciences, University of Craiova, A. I. Cuza, 13, Romania <em>Manuscript received 11 November 1998, accepted 16 November 1998</em> <strong>New complexes of bivalent Ni, Pd, Pt, Zn, Cd and Hg with 3-thionicotinoylaminodibenzofuran (TNADBF) are described. </strong><strong>The complexes are found to be of [MLCl<sub>2</sub>] type and the thioamide acts as bidentate ligand using both sulphur and nitrogen </strong><strong>atoms as donors in the formation of complexes.</strong>

APA, Harvard, Vancouver, ISO, and other styles

6

Stejic, Petar, and Tivadar Gaudenyi. "PLAVINE DUMBRAVE (PONDNOŽJE VRŠAČKIH PLANINA, BANAT)." ЗАПИСНИЦИ СРПСКОГ ГЕОЛОШКОГ ДРУШТВА 2024 (March 11, 2025): 62–82. https://doi.org/10.5281/zenodo.15008303.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Dom, Rosanna. "Klaus Bochmann / Vasile Dumbrava / Dietmar Müller / Victoria Reinhardt (Hgg.), Die Republik Moldau. Ein Handbuch." Comparative Southeast European Studies 61, no. 1 (2013): 148–51. http://dx.doi.org/10.1515/soeu-2013-610109.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

C., Parnau, Kriza A., Pop V., and Udrea S. "Complexes of tin(IV) and zirconium(IV) with Schiff bases derived from isatin and diamines." Journal of Indian Chemical Society Vol. 82, Jan 2005 (2005): 71–73. https://doi.org/10.5281/zenodo.5824214.

Full text

Abstract:

Faculty of Chemistry, Department of Inorganic Chemistry, University of Bucharest. Romania. Str. Dumbrava Rosie, 23 <em>E-mail</em>: veronica.pop@k.ro Romanian Institute of Organic Chemistry, Bucharest. Spl. Independentei 202 <em>Manuscript received 7 May 2003, accepted 30 August 2004</em> A series of new metal chelates of Sn<sup>IV</sup> and Zr<sup>IV</sup> with the Schiff bases formed by condensation of isatin with diamines have been synthesized and characterized via elemental analyses, infrared, electronic, <sup>1</sup>H NMR spectroscopy and molar conductivity measurements. The dat

APA, Harvard, Vancouver, ISO, and other styles

9

Chetan, Felicia, Cornel Chetan, Ioana Paula Moraru, and Alina Simon. "The reaction of some winter wheat variety at cultivation in the conservative system in the Transylvanian Plain area." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Agriculture 73, no. 2 (2016): 176. http://dx.doi.org/10.15835/buasvmcn-agr:12050.

Full text

Abstract:

Introduction: In Europe between wheat cultivators countries, Romania ranks fifth with an area of 2.07 million hectares with a production of 7.45 million tonnes and production obtained is just 3601 kg /ha (www.ager.press.ro).Aims: Through the experience realised at ARDS Turda we follow the behavior of native varieties grȃu autumn, compared ȋn varieties of foreign origin, to make recommendations on their pretability to different systems of culture and levels of fertilization.Materials and Method: The experiment realized at the ARDS Turda, includes two ways to work the soil, a classic conventiona

APA, Harvard, Vancouver, ISO, and other styles

10

Angela, Kriza, Pricop Laurentiu, Meghea Aurelia, and Stanica Nicolae. "Template synthesis of chromium(III), cobalt(II), nickel(II), copper(II) and cadmium(II) complexes with a tetradentate Schiff base, glyoxilidene-his-2-aminoethylpyridine." Journal of Indian Chemical Society Vol. 78, Sep 2001 (2001): 448–50. https://doi.org/10.5281/zenodo.5912513.

Full text

Abstract:

University of Bucharest, Faculty of Chemistry, Inorganic Chemistry Laboratory, Str. Dumbrava Rosie nr. 23, 70254-Bucharest, Romania University Politehnica Bucharest, Faculty of Industrial Chemistry, Str. Polizu nr. 1, 78126-Bucharest, Romania Institute of Physical Chemistry, Coordination Chemistry Laboratory, Spl. Independentei nr. 202, 77208-Bucharest, Romania <em>Manuscript received 2 March 2000, revised 18 October 2000. accepted 10 February 2001</em> Some new complexes of Cr<sup>III</sup>, Co<sup>II</sup>, Ni<sup>II</sup>, Cu<sup>II</sup> and Cd<sup>II</sup> have been synthesized with a tet

APA, Harvard, Vancouver, ISO, and other styles

11

A., Kriza, Reiss A., Blejoiu S., Brujan L., and Stanica N. "Transition metal complexes of heterocyclic ligands. Part-II. Complex compounds of ions with d6, d7, d8 and d10 electronic configuration with 3-N-dibenzofurylthiourea." Journal of Indian Chemical Society Vol. 77, Oct 2000 (2000): 488–89. https://doi.org/10.5281/zenodo.5867795.

Full text

Abstract:

University of Bucharest, Faculty of Chemistry, 23, Dumbrava Rosie - Bucuresti, Romania University of Craiova, Faculty of Chemistry, 13, A. I. Cuza 1100 - Craiova, Romania ICECHIM Center of Physical Chemistry Bucharest, 202, Splaiul Independentei - Bucuresti, Romania <em>Manuscript received 1 March 2000, accepted 1 July 2000</em> The title complexes are found to be of the types [MLCl<sub>2</sub>], where M = Co<sup>II</sup>, Ni<sup>II</sup>, Pd<sup>II</sup> and Pt<sup>II</sup>, [FeL<sub>2</sub>Cl<sub>2</sub>] and [(CuCI)<sub>2</sub>L<sub>2</sub>], and L = 3-<em>N</em>-dibenzofurylthiourea. The t

APA, Harvard, Vancouver, ISO, and other styles

12

Bernath-Doncuțiu, Andrea, and Doina Halcea. "Relocarea colecției Muzeului de Etnografie Universală Franz Binder din cadrul Complexului Național Muzeal ASTRA. Un demers planificat în graniţele conservării preventive." Revista Muzeelor 1 (2023): 127–43. http://dx.doi.org/10.61789/rm.2023.08.

Full text

Abstract:

"In 2019, the non-European movable cultural heritage belonging to the Franz Binder Museum was relocated in Sibiu, from the Hermes House (no. 11, Piața Mică), to the ASTRA Centre for Heritage (no. 20, Pădurea Dumbrava). In this context, the department of collection care of the ASTRA National Museum Complex, which is mainly responsible for the preventive conservation and administration of the museum’s cultural heritage, was entrusted with the task of carrying out the project. The actual period, from planning, organising, and preparation to the completion of the transport, lasted four months, and

APA, Harvard, Vancouver, ISO, and other styles

13

Veronica, Pop, Kriza Angela, Ilis Monica, and Popa Dana. "Synthesis and stability studies in physiological-like conditions of a new compound of copper(II) with mixed ligands." Journal of Indian Chemical Society Vol. 80, July 2003 (2003): 673–76. https://doi.org/10.5281/zenodo.5835348.

Full text

Abstract:

University of Bucharest, Faculty of Chemistry, Department of Inorganic Chemistry, 23 Dumbrava Rosie, Bucuresti, Romania <em>E-mail</em>: veronica.pop@k.ro <em>Manuscript received 14 November 2002, accepted 31 January 2003</em> In order to obtain new potential antioxidants with molecular mass lower than those of the metal-proteins, a new copper(II) compound with mixed ligands, L-histidine and urea was synthesised. The compounds containing only one of the two mentioned ligands, Cu-urea and Cu-L-histidine was also synthesised as intermediates in the synthesis of the compound with mixed ligands or

APA, Harvard, Vancouver, ISO, and other styles

14

Florin, Murariu, Murariu Otilia Cristina, Gîlca Ioan, and Postolache Narcisa. "A biomechanical study of a boxer jumping approach and techniques used by sport horses within Dumbrava, Timişeşti stallions storage, Romania." Current Opinion in Biotechnology 24 (July 2013): S55. http://dx.doi.org/10.1016/j.copbio.2013.05.136.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Suciu, Alexandra Loredana, Laura Șopterean, Rozalia Kadar, et al. "The Influence of the Number of Fungicide Treatments upon the Quantity and Quality of Winter Wheat Yield in Climatic Conditions of ARDS Turda." Romanian Agricultural Research 35 (2018): 221–28. http://dx.doi.org/10.59665/rar3526.

Full text

Abstract:

The effect of the number of fungicide treatments in vegetation on the quality and quantity of the autumn yield was studied in 2012-2014 at Agricultural Research & Development Station (ARDS) Turda, in the Phytopathology laboratory field. The study was conducted with three wheat varieties: Arieșan, Dumbrava and Andrada and the test variants were: no treatment (T0), one treatment, (T1) and two treatments (T2). The vegetation treatments were carried out with the products Nativo (1 l/ha) and Prosaro (1 l/ha). Since the Fusarium head blight, produced by different species of the genus Fusarium, i

APA, Harvard, Vancouver, ISO, and other styles

16

Feldmane, Daina, Dzintra Dēķena, and Edgars Cirša. "Frost Tolerance of Flower Buds, Self-Pollination and Fruit Quality Traits in Local Sour Cherries of Latvia." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 76, no. 4 (2022): 469–76. http://dx.doi.org/10.2478/prolas-2022-0072.

Full text

Abstract:

Abstract The aim of the study was to characterise the variability of flower bud frost tolerance, self-pollination and fruit quality in Latvian local sour cherries; and to select the most promising aces-sions. Data on fruit set after self-pollination, frost tolerance of flower buds, fruit and stone weight, stem retention force and soluble solid content were collected for 29 accessions of local cherries in 2016–2019. Sour cherry cv. ‘Latvijas Zemais’ clones no. 64, D7, and 4 were the most promising for fruit processing; clones no. 62, 65, Matkules, and Lietuvas were promising as pollinators due

APA, Harvard, Vancouver, ISO, and other styles

17

Angela, Kriza, Spinu Cezar, Pop Veronica, and F. Kriza Angela. "Studies on N-[2-thienylmethylidene]-2-hydroxy-1-aminoethane complexes of cobalt-, nickel- and copper(II)." Journal of Indian Chemical Society Vol. 80, Aug 2003 (2003): 780–82. https://doi.org/10.5281/zenodo.5836534.

Full text

Abstract:

University of Bucharest, Faculty of Chemistry, Department of Inorganic Chemistry, str. Dumbrava Rosie 23, Bucharest, Romania <em>E-mail</em> : veronica.pop@k.ro University of Craiova, Faculty of Chemistry, Department of Inorganic Chemistry, str. Alexandru loan Cuza 13, Craiova, Dolj, Romania Sc. "Andrei Saguna", Calea Vacaresti 234, Bucharest, Romania <em>Manuscript received 31 May 2002, revised 3 March 2003, accepted 2 April 2003</em> Complexes of the types ML<sub>2</sub> and ML<sub>2</sub>CI<sub>2</sub> where M is Co<sup>II</sup> , Ni<sup>II</sup> and Cu<sup>II</sup> , and Lis the

APA, Harvard, Vancouver, ISO, and other styles

18

Evans, Laura. "Vademecum Contemporary History Moldova: A Guide to Archives, Research Institutions, Libraries, Associations, Museums and Sites of Memoryby Klaus Bochmann and Marina Dumbrava, eds." Slavic & East European Information Resources 16, no. 1-2 (2015): 97–98. http://dx.doi.org/10.1080/15228886.2015.1012576.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Poruţiu, Andra, Felix Arion, Iulia Mureşan, and Olga Stefko. "Considerations Regarding a Comparative Economic Approach on Corn and Wheat Crops on a Representative Soil in Romania." Zeszyty Naukowe SGGW w Warszawie - Problemy Rolnictwa Światowego 16, no. 4 (2016): 272–80. http://dx.doi.org/10.22630/prs.2016.16.4.120.

Full text

Abstract:

The research refers on the production results obtained on corn crops (Turda STAR Variety) and wheat crops (Dumbrava variety) (cultivated following corn crops) conducted on an argyle chernozem soil in Cluj County, Romania. The study exhibits the differentiated fertilization systems (the effect of the nitrogen-phosphorous interaction) involved in obtaining high productions of wheat and corn in the reference area. For corn crops the rate of return, as a mean of all the values that derive from all nitrogen-phosphorous combinations was at a very high level, 80%, with a maximum of the individual val

APA, Harvard, Vancouver, ISO, and other styles

20

Oleg, CAZACU. "REPERE DIN ISTORIA FANFAREI RURALE ÎN SPAȚIUL CULTURAL AL REPUBLICII MOLDOVA." STUDIA UNIVERSITATIS MOLDAVIAE Științe Umanistice, no. 4(154) (2022): 29–33. https://doi.org/10.5281/zenodo.6583879.

Full text

Abstract:

Un domeniu valoros al culturii tradiționale românești îl constituie muzica de fanfară. În arta de tradiție orală instrumentele aerofone au o istorie bogată cu rădăcinile în cultura traco-geto-dacă. Constituirea fanfarei ca formație organizată cu un anumit statut de activitate este nemijlocit legată de reforma armatei naționale din secolul al XIX-lea. Totodată, dezvoltarea profesionalismului instrumental de tradiție orală, tendința de îmbogățire a instrumentarului de către reprezentanții acestuia – lăutarii, a dus la crearea fanf

APA, Harvard, Vancouver, ISO, and other styles

21

SUCIU, Alexandra, Raluca MICLEA, Laura ȘOPTEREAN, Ioan HAȘ, and Carmen PUIA. "The Influence of Fusarium Infections on the Quality Parameters and Production of Four Wheat Varietes, in Different Infection Conditions." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Agriculture 70, no. 1 (2013): 67–74. http://dx.doi.org/10.15835/buasvmcn-agr:9772.

Full text

Abstract:

Abstract. Wheat is one of the oldest cultivated plants and most important food plant, the wheat flour bread is the basic food for majority of world population. At the same time the corn crop is affected by many diseases that cause quantitative and qualitative losses. From the many diseases common to the wheat culture, fusarium head blight, produced by species of the Fusarium genus, is appreciated in most parts of the world, as one of the most damaging disease. In addition to losses of production, 10-2 percent in favourable conditions, the flour for bread that came from crops affected by Fusari

APA, Harvard, Vancouver, ISO, and other styles

22

PORUÅ¢IU, Andra Ramona, Mihai RUSU, Marilena MÄ‚RGHITAȘ, Constantin TOADER, and Lavinia MOLDOVAN. "Research Concerning the Agrochemical Optimization of the Fertilization System for Wheat Crops in the Transylvanian Plain." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Agriculture 70, no. 1 (2013): 134–40. http://dx.doi.org/10.15835/buasvmcn-agr:9402.

Full text

Abstract:

The current research is based on the production results obtained on wheat crops in long term experiments conducted on an argyle phaeozem soil at SCA Turda.The goal of this research is to scientifically, agrochemically and economically substantiate the differentiated fertilization systems involved in obtaining big productions in the reference area. In this study we tried to track the effect of the nitrogen-potassium interaction in achieving the productions obtained in 2012. The research presents the stated results as annual (partial) values and it will continue with them as being reference valu

APA, Harvard, Vancouver, ISO, and other styles

23

Holla, Vijaykumar, Arash Ronaghy, Richard K. Yang, et al. "Abstract 2128: Genomic alterations in DNA mismatch repair (dMMR)." Cancer Research 83, no. 7_Supplement (2023): 2128. http://dx.doi.org/10.1158/1538-7445.am2023-2128.

Full text

Abstract:

Abstract Background PD-1 inhibitors have been shown to be effective in advanced cancer patients with mismatch repair deficient tumors (dMMR) in a tumor agnostic fashion. dMMR testing by immunohistochemistry (IHC) is infrequently performed outside of colorectal and endometrial cancer. In contrast, comprehensive genomic sequencing (CGS) for somatic genomic alterations, is frequently perfomed across tumor types. We hypothesized that CGS may identify alterations in dMMR genes (MLH1, MSH2, MSH6, PMS2), and that patients with genomic MMR alterations will have higher rates of dMMR loss by IHC. Method

APA, Harvard, Vancouver, ISO, and other styles

24

Sharma, Manish, Anne M. Noonan, Daniel A. Vaena, et al. "Preliminary antitumor activity of COM701 in combination with COM902 and pembrolizumab in patients with MSS-CRC and liver metastases." Journal of Clinical Oncology 42, no. 16_suppl (2024): 3597. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.3597.

Full text

Abstract:

3597 Background: There is a high unmet need for the treatment of patients [pts] with metastatic microsatellite stable colorectal cancer [MSS-CRC]. We reported encouraging preliminary antitumor activity with the combination of COM701 + nivolumab in patients with MSS-CRC and liver metastases [12/22(77%)], [ORR 2/17 (12%); disease control rate [DCR] 5/17 (29%)]1. COM701 is a novel, 1st-in-class immune checkpoint inhibitor [ICI] that binds to PVRIG, a DNAM-1 axis member, leading to activation of T and NK-cells; COM902 is an ICI of TIGIT. Pembrolizumab is an ICI of PD-1. We hypothesized that in pts

APA, Harvard, Vancouver, ISO, and other styles

25

DiPeri, Timothy P., Kurt W. Evans, Bailiang Wang, et al. "Abstract B126: Co-clinical trial of novel bispecific anti-HER2 antibody Zanidatamab in Patient-Derived Xenografts." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): B126. http://dx.doi.org/10.1158/1535-7163.targ-23-b126.

Full text

Abstract:

Abstract Background: Zanidatamab is a bispecific HER2-targeted antibody in clinical development which has demonstrated antitumor activity in a broad range of HER2 amplified/expressing solid tumors. We report the antitumor activity of zanidatamab in vivo by utilizing patient-derived xenograft (PDX) models developed from pre-treatment or post-progression biopsies from the first-in-human zanidatamab phase I study (NCT02892123). Methods: PDXs were established by implanting 1-2 core biopsies from HER2 expressing tumors into immunodeficient mice. The PDXs that developed were expanded and treated wit

APA, Harvard, Vancouver, ISO, and other styles

26

Ruicănescu, Adrian, Amalia-Raluca Dumbravă, and Andreea-Cătălina Drăghici. "Capnodis cariosa (Pallas, 1776) found in a new Romanian location at the northern limit of its distribution range (Coleoptera: Buprestidae)." Fragmenta entomologica 54, no. 1 (2022): 155–58. https://doi.org/10.13133/2284-4880/442.

Full text

Abstract:

Ruicănescu, Adrian, Dumbravă, Amalia-Raluca, Drăghici, Andreea-Cătălina (2022): Capnodis cariosa (Pallas, 1776) found in a new Romanian location at the northern limit of its distribution range (Coleoptera: Buprestidae). Fragmenta entomologica 54 (1): 155-158, DOI: 10.13133/2284-4880/442, URL: http://dx.doi.org/10.13133/2284-4880/442

APA, Harvard, Vancouver, ISO, and other styles

27

Brusatte, Stephen L., Mihai Dumbravă, Mátyás Vremir, Zoltán Csiki-Sava, Radu Totoianu, and Mark A. Norell. "A catalog of Zalmoxes (Dinosauria: Ornithopoda) specimens from the Upper Cretaceous Nălaț-Vad locality, Haţeg Basin, Romania." American Museum Novitates 2017, no. 3884 (2017): 1–36. https://doi.org/10.1206/3884.1.

Full text

Abstract:

Brusatte, Stephen L., Dumbravă, Mihai, Vremir, Mátyás, Csiki-Sava, Zoltán, Totoianu, Radu, Norell, Mark A. (2017): A catalog of Zalmoxes (Dinosauria: Ornithopoda) specimens from the Upper Cretaceous Nălaț-Vad locality, Haţeg Basin, Romania. American Museum Novitates 2017 (3884): 1-36, DOI: 10.1206/3884.1, URL: http://www.bioone.org/doi/10.1206/3884.1

APA, Harvard, Vancouver, ISO, and other styles

28

Augustin, Felix J., Dylan Bastiaans, Mihai D. Dumbravă, and Zoltán Csiki-Sava. "A new ornithopod dinosaur, Transylvanosaurus platycephalus gen. et sp. nov. (Dinosauria: Ornithischia), from the Upper Cretaceous of the Haţeg Basin, Romania." Journal of Vertebrate Paleontology 42, no. 2 (2022): 1–23. https://doi.org/10.1080/02724634.2022.2133610.

Full text

Abstract:

Augustin, Felix J., Bastiaans, Dylan, Dumbravă, Mihai D., Csiki-Sava, Zoltán (2022): A new ornithopod dinosaur, <i>Transylvanosaurus platycephalus</i> gen. et sp. nov. (Dinosauria: Ornithischia), from the Upper Cretaceous of the Haţeg Basin, Romania. Journal of Vertebrate Paleontology (e2133610) 42 (2): 1-23, DOI: 10.1080/02724634.2022.2133610, URL: http://dx.doi.org/10.1080/02724634.2022.2133610

APA, Harvard, Vancouver, ISO, and other styles

29

Zhao, Ming, Timothy P. DiPeri, Gabriela Raso, et al. "Abstract 1791: Epigenetically upregulating TROP2 enhances therapeutic efficacy of TROP2 ADC sacitizumab govitecan." Cancer Research 82, no. 12_Supplement (2022): 1791. http://dx.doi.org/10.1158/1538-7445.am2022-1791.

Full text

Abstract:

Abstract Purpose: TROP2 is overexpressed in many tumor types and is being actively pursued as a target. Sacituzumab govitecan (SG), a humanized anti-TROP2 antibody conjugated with SN-38, was approved for treatment of metastatic triple negative breast cancer, with the greatest efficacy in patients with medium or high TROP2 levels. We sought to enhance efficacy of TROP2-targeted therapies by pharmacological regulation of TROP2 expression. Methods: TROP2 levels were assessed by immunohistochemistry (IHC) in two sets of breast tumors: a set of surgical samples and a tissue microarray. TROP2 mRNA e

APA, Harvard, Vancouver, ISO, and other styles

30

Dumbrava, Ecaterina I., Glenn J. Hanna, Gregory M. Cote, et al. "Abstract CT123: A phase 2 study of the MDM2 inhibitor milademetan in patients with TP53-wild type and MDM2-amplified advanced or metastatic solid tumors (MANTRA-2)." Cancer Research 82, no. 12_Supplement (2022): CT123. http://dx.doi.org/10.1158/1538-7445.am2022-ct123.

Full text

Abstract:

Abstract Background: Murine double minute 2 (MDM2) is a potent negative regulator of the tumor suppressor p53. MDM2 induces degradation of p53 and promotes tumorigenesis in solid tumors, and preclinical models have shown that inhibition of MDM2 can restore p53 tumor suppressor activity in TP53-wild type (WT), MDM2-amplified tumors. We performed a mutual exclusivity analysis of patients with solid tumors (n=42,125; AACR Project GENIE) and found that the frequency of co-occurring TP53 mutations decreased with increasing MDM2 copy number. An MDM2 copy number of 12 was chosen as the threshold. An

APA, Harvard, Vancouver, ISO, and other styles

31

Papadopoulos, Kyriakos, Michael Cecchini, Juanita S. Lopez, et al. "Abstract CT276: Preliminary analysis of pharmacokinetic (PK) and target engagement biomarkers from a first in human phase 1 study of immunomodulatory aryl hydrocarbon receptor (AhR) inhibitor BAY2416964." Cancer Research 83, no. 8_Supplement (2023): CT276. http://dx.doi.org/10.1158/1538-7445.am2023-ct276.

Full text

Abstract:

Abstract Introduction: Many patients do not benefit from immunotherapies targeting immune checkpoints such as PD(L)-1 due to a variety of resistance mechanisms. The AhR pathway is downstream of the Trp-IDO/TDO-Kyn axis. High levels of immune-suppressive AhR-activating ligands, such as kynurenine derived from IDO1/TDO2-expressing tumors, have been implicated as a potential resistance mechanism and are associated with poor responses to PD-1 therapies. Compared with inhibition of IDO1/TDO2 alone, direct AhR inhibition can block the activation of this transcription factor and may better counteract

APA, Harvard, Vancouver, ISO, and other styles

32

Dumbrava, Ecaterina E., Daniel Olson, Samuel Saibil, et al. "Abstract CT081: A phase 1/2 study investigating the safety and efficacy of autologous TAC T cells in subjects with unresectable, locally advanced, or metastatic claudin 18.2+ solid tumors." Cancer Research 84, no. 7_Supplement (2024): CT081. http://dx.doi.org/10.1158/1538-7445.am2024-ct081.

Full text

Abstract:

Abstract Background: CLDN18.2 is a tight junction protein found in differentiated gastric epithelial cells, which can become abnormally or ectopically expressed in a number of solid tumor indications. This exposure profile illustrates the potential of CLDN18.2 as a candidate for targeted therapy. To date, there are no approved therapeutic agents directed against this target. The T cell antigen coupler (TAC) technology is an approach to modifying T cells ex vivo, which allows recognition and cytotoxicity of tumor cells by co-opting the natural T cell receptor. TAC T cells demonstrate a safer pr

APA, Harvard, Vancouver, ISO, and other styles

33

Davis, Andrew A., Ecaterina E. Dumbrava, Aparna Kalyan, et al. "Abstract CT159: Phase I trial of trastuzumab deruxtecan in combination with neratinib in solid tumors with HER2 alterations (NCI 10495)." Cancer Research 84, no. 7_Supplement (2024): CT159. http://dx.doi.org/10.1158/1538-7445.am2024-ct159.

Full text

Abstract:

Abstract Background: Human epidermal growth factor receptor 2 (HER2) overexpression, amplification, or mutation occurs across a variety of solid tumors. Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) that has been approved by the FDA for HER2-overexpressed advanced breast, gastroesophageal cancers, HER2-low breast cancer, and HER2-mutated non-small cell lung cancer. However, some patients do not derive clinical benefit from T-DXd, and drug resistance is inevitable. Preclinical studies demonstrated that neratinib, an oral irreversible pan-HER tyrosine kinase inhibitor, can i

APA, Harvard, Vancouver, ISO, and other styles

34

Schlechter, Benjamin, Ecaterina Dumbrava, Mridula George, et al. "Abstract B035: A phase I/II trial investigating safety and efficacy of autologous TAC01-HER2 in relapsed or refractory solid tumors." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): B035. http://dx.doi.org/10.1158/1535-7163.targ-23-b035.

Full text

Abstract:

Abstract Despite therapeutic developments for patients with advanced HER2+ solid tumors, significant unmet medical needs still exist. The T cell antigen coupler (TAC) technology is an approach to modifying T cells ex vivo, which allows recognition and cytotoxicity of tumor cells by co-opting the natural T cell receptor. TAC T cells demonstrate a safer profile than chimeric antigen receptor T cells. TAC01-HER2 is an autologous T-cell product comprising T cells expressing HER2 TAC. The ongoing clinical trial (NCT04727151) is evaluating the safety and preliminary anti-tumor activity of TAC01-HER2

APA, Harvard, Vancouver, ISO, and other styles

35

Schlechter, Benjamin, Ecaterina Dumbrava, Samuel Saibil, et al. "Abstract C028: A phase 1/2 study investigating the safety and efficacy of autologous TAC T cells in subjects with unresectable, locally advanced or metastatic claudin 18.2+ solid tumors." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): C028. http://dx.doi.org/10.1158/1535-7163.targ-23-c028.

Full text

Abstract:

Abstract CLDN18.2 is a tight junction protein found in differentiated gastric epithelial cells which can become abnormally expressed in a number of solid malignancies. This exposure profile illustrates the potential of CLDN18.2 as a candidate for targeted therapy. To date, there are no approved therapeutic agents directed against this target but promising data exist using monoclonal antibodies and conventional chimeric antigen receptor (CAR) T therapy. The T cell antigen coupler (TAC) technology is an approach to modifying T cells ex vivo, which allows recognition and cytotoxicity of tumor cel

APA, Harvard, Vancouver, ISO, and other styles

36

Cupșa, Diana, Severus-Daniel Covaciu-Marcov, Robert-Liviu-Mihai Rengle, Amalia-Raluca Dumbravă, Sára Ferenți, and Adriana Petruș-Vancea. "Can wildlife mortality on a local road tell something general? An answer from a protected area in south-western Romania." Turkish Journal of Zoology 48, no. 1 (2023): 84–97. https://doi.org/10.55730/1300-0179.3162.

Full text

Abstract:

Cupșa, Diana, Covaciu-Marcov, Severus-Daniel, Rengle, Robert-Liviu-Mihai, Dumbravă, Amalia-Raluca, Ferenți, Sára, Petruș-Vancea, Adriana (2024): Can wildlife mortality on a local road tell something general? An answer from a protected area in south-western Romania. Turkish Journal of Zoology 48 (1): 84-97, DOI: 10.55730/1300-0179.3162, URL: http://dx.doi.org/10.55730/1300-0179.3162

APA, Harvard, Vancouver, ISO, and other styles

37

Dumbrava, Ecaterina E., Daniel Olson, Benjamin L. Schlechter, et al. "Abstract CT247: A phase I/II trial investigating safety and efficacy of autologous TAC T cells targeting HER2 in relapsed or refractory solid tumors (TACTIC-2)." Cancer Research 82, no. 12_Supplement (2022): CT247. http://dx.doi.org/10.1158/1538-7445.am2022-ct247.

Full text

Abstract:

Abstract Background: Despite recent therapeutic advances for patients (pts) with breast, colorectal and gastroesophageal cancers with HER2 overexpression, there is still a significant unmet medical need for better treatment options for HER2-positive solid tumors, especially those with low or intermediate HER2 expression (1+ and 2+ by immunohistochemistry (IHC)). T Cell Antigen-Coupler (TAC) technology is a novel way to genetically modify T cells and to redirect these T cells to target cancer antigens and to activate T cells naturally by co-opting the natural T cell Receptor (TCR). TAC01-HER2 i

APA, Harvard, Vancouver, ISO, and other styles

38

DiPeri, Timothy D., Kathleen Kong, Daniel D. Karp, et al. "Abstract 1588: Discordance of HER2 expression and/or amplification on repeat testing." Cancer Research 82, no. 12_Supplement (2022): 1588. http://dx.doi.org/10.1158/1538-7445.am2022-1588.

Full text

Abstract:

Abstract Purpose: Evaluation of human epidermal growth factor receptor 2 (HER2) expression/amplification status is critical when considering HER2-targeted therapies. We sought to assess discordance of HER2 status in patients with HER2-amplified/expressing solid tumors who underwent a repeat biopsy for pre-trial screening. Methods: Consenting patients with solid tumors and documented HER2 expression by immunohistochemistry (IHC) or amplification by fluorescent in situ hybridization/next generation sequencing (FISH/NGS) on historical local testing underwent a new biopsy for central reevaluation

APA, Harvard, Vancouver, ISO, and other styles

39

Ngoi, Natalie Y., Heather Y. Lin, Ecaterina Dumbrava, et al. "Abstract 6181: Dynamic changes in monocyte and reticulocyte counts predict mechanism-based anemia development and recovery during ATR inhibitor treatment in phase I/II trials." Cancer Research 83, no. 7_Supplement (2023): 6181. http://dx.doi.org/10.1158/1538-7445.am2023-6181.

Full text

Abstract:

Abstract Introduction: Clinical trials are exploring ATR inhibitors (ATRi) in genomically selected contexts. However, dose-dependent anemia has limited the therapeutic index of this class. We hypothesized that monocytes and reticulocytes are more vulnerable to ATRi due to their lack of base excision repair and high levels of oxidative stress, respectively. We sought to examine the kinetics of decline and recovery of red blood cell (RBC) and reticulocyte indices, in relation to hemoglobin (Hb), in the first 28 days after ATRi initiation. Methods: We retrospectively retrieved peripheral blood ce

APA, Harvard, Vancouver, ISO, and other styles

40

Cabanas, Elena Garralda, Elisa Fontana, Honey Kumar Oberoi, et al. "Abstract CT265: Phase 1 dose-escalation study of SGN-TGT monotherapy in patients with advanced malignancies." Cancer Research 83, no. 8_Supplement (2023): CT265. http://dx.doi.org/10.1158/1538-7445.am2023-ct265.

Full text

Abstract:

Abstract Background: T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is an inhibitory immune checkpoint receptor expressed on subsets of T-cells and natural killer (NK) cells. TIGIT inhibits T and NK cell function by binding to CD155 and CD112. SEA-TGT is an investigational human, nonfucosylated monoclonal antibody directed against TIGIT, blocking TIGIT's interaction with CD155 and CD112. SGNTGT-001 (NCT04254107) is a phase 1, open-label, multicenter study of SEA-TGT in patients (pts) with advanced malignancies (solid tumors and lymph

APA, Harvard, Vancouver, ISO, and other styles

41

Dumbrava, Ecaterina Elena, Daniel Olson, Samuel Saibil, et al. "Abstract CT234: A phase I/II trial investigating safety and efficacy of autologous TAC01-HER2 in relapsed or refractory solid tumors." Cancer Research 83, no. 8_Supplement (2023): CT234. http://dx.doi.org/10.1158/1538-7445.am2023-ct234.

Full text

Abstract:

Abstract Background: Despite recent therapeutic developments for patients with advanced, metastatic, unresectable HER2+ solid tumors, significant unmet medical needs still exist, especially in tumors other than breast and gastric. The T cell antigen coupler (TAC) technology is a novel approach to modifying T cells, allowing them to recognize and treat HER2+ solid tumors. The TAC receptor redirects T cells to tumor cells, and upon tumor cell recognition, co-opts the natural T cell receptor (TCR) to yield safer anti-tumor responses versus chimeric antigen receptor (CAR) T cells. In preclinical s

APA, Harvard, Vancouver, ISO, and other styles

42

Nelson, Blessie Elizabeth, Filip Janku, Siqing Fu, et al. "Abstract CT107: Phase Ib Study of Pembrolizumab in Combination with Intratumoral Injection of Clostridium novyi-NT in Patients with Advanced Solid Tumors." Cancer Research 83, no. 8_Supplement (2023): CT107. http://dx.doi.org/10.1158/1538-7445.am2023-ct107.

Full text

Abstract:

Abstract BACKGROUND: Intra-tumoral Clostridium novyi-NT (non-toxic) is an attenuated strain of C. novyi lacking alpha toxin replication within hypoxic tumor regions, causing tumor cell lysis and inflammation. Immunotherapy (IO) augments anticancer activity with intratumoral agents in prior preclinical and clinical studies. This phase 1b dose escalation study assessed safety and potential synergistic effects of pembrolizumab and C. novyi-NT in advanced solid tumors. METHODS: We enrolled patients with percutaneous injectable, solid tumors to receive single intratumoral injection of C. novyi-NT a

APA, Harvard, Vancouver, ISO, and other styles

43

Dumbrava, Ecaterina E., Emma J. Montazari, Uyen M. Vu, et al. "Abstract CT292: Phase II study of pembrolizumab in combination with lenvatinib in patients with triple negative breast cancer (TNBC), non-small cell lung cancer (NSCLC), and other tumor types and brain metastases." Cancer Research 84, no. 7_Supplement (2024): CT292. http://dx.doi.org/10.1158/1538-7445.am2024-ct292.

Full text

Abstract:

Abstract Background: Many patients develop brain metastasis during the course of their disease and it represents the cause of death in more than half of them. The prognosis and survival of patients with brain metastases remains poor with limited palliative treatment options. Thus, there is a need to develop new strategies for the therapeutic management of patients with brain metastases. Inflammatory stimuli originating from CNS tumors may increase the permeability of the blood-brain barrier and promote immune cell activation and infiltration into tumors. Several studies have demonstrated now t

APA, Harvard, Vancouver, ISO, and other styles

44

Dumbrava, Ecaterina E., Amber M. Kennon, Rashmi K. Murthy, et al. "Abstract CT289: A phase II study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in patients with HER2-positive metastatic solid tumors and metastases to brain (TUCATEMEB)." Cancer Research 84, no. 7_Supplement (2024): CT289. http://dx.doi.org/10.1158/1538-7445.am2024-ct289.

Full text

Abstract:

Abstract Background: HER2 overexpression or amplification is a validated prognostic and predictive biomarker for treatments in several tumor types. The development of brain metastases is an unfortunate and common complication in patients with metastatic cancer and the incidence of brain metastases continues to grow as advances in cancer treatment extend the survival. Unfortunately many of the clinical trials still exclude patients with brain metastases. Tucatinib is a selective small molecule HER2 inibitor that has shown intracranial activity and it is approved with trastuzumab and capecitabin

APA, Harvard, Vancouver, ISO, and other styles

45

Uzunparmak, Burak, Fei Su, Amber M. Johnson, et al. "Abstract 939: Comprehensive genomic and transcriptomic analysis to guide therapy for patients with metastatic solid tumors." Cancer Research 84, no. 6_Supplement (2024): 939. http://dx.doi.org/10.1158/1538-7445.am2024-939.

Full text

Abstract:

Abstract Introduction: Precision oncology, which aims to profile tumors for identifying actionable alterations to guide therapy has become mainstream in cancer clinics. While most approaches focus on DNA aberrancies on targeted panels, not all patients’ tumors show targetable genomic alterations in these limited gene sets, indicating a need for more comprehensive methodologies combining whole exome (WES) and transcriptome sequencing (RNAseq) to direct a larger fraction of patients to therapies. Here, we aimed to compare the feasibility and utility of BostonGene’s (BG) analytical platform with

APA, Harvard, Vancouver, ISO, and other styles

46

Dumbrava, Ecaterina E., Fabio M. Iwamoto, Mark Agulnik, et al. "Abstract CT066: Phase 1 study of MDM2 antagonist ASTX295 in patients with solid tumors with wild-type TP53." Cancer Research 84, no. 7_Supplement (2024): CT066. http://dx.doi.org/10.1158/1538-7445.am2024-ct066.

Full text

Abstract:

Abstract Background: ASTX295 is a novel small molecule antagonist of human Murine Double Minute 2 (MDM2), which tightly regulates the level and activity of the p53 tumor suppressor. To minimize potential thrombocytopenia previously seen with antagonism of this target, ASTX295 was designed to have a short half-life (t1/2) with decreased bone marrow (BM) exposure. ASTX295 has proapoptotic and tumor growth inhibitory activity in preclinical cancer (CA) models. We report here the safety and preliminary efficacy of the phase 1 and dose expansion portions of Study ASTX295-01. Methods: ASTX295-01 is

APA, Harvard, Vancouver, ISO, and other styles

47

Dumbrava, Ecaterina E., Christopher T. Chen, Gregory M. Cote, et al. "Abstract B034: A phase 2 basket study of the oral MDM2 inhibitor milademetan for MDM2-amplified advanced solid tumors (MANTRA-2)." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): B034. http://dx.doi.org/10.1158/1535-7163.targ-23-b034.

Full text

Abstract:

Abstract Milademetan is an oral, selective, small molecular inhibitor of the MDM2-p53 complex that reactivates p53 to induce cancer cell apoptosis and tumor regressions in nonclinical models. Clinically, MDM2 gene amplification (amp) occurs in 1–2% of advanced solid tumors and is associated with a poor prognosis. Preliminary antitumor activity was seen in patients with MDM2 amp and TP53 wild-type (WT) tumors in a phase 1 clinical trial [Tirunagaru et al. AACR-NCI-EORTC 2021]. We conducted a phase 2 basket study to evaluate the efficacy of milademetan in patients with advanced or metastatic sol

APA, Harvard, Vancouver, ISO, and other styles

48

George, Goldy C., Sarina A. Piha-Paul, Siqing Fu, et al. "Abstract C067: Patient-reported baseline symptomatic adverse events in early-phase trials of combination treatments with immune checkpoint blockade, and their association with concurrent global health status, health utilities and clinical factors." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): C067. http://dx.doi.org/10.1158/1535-7163.targ-23-c067.

Full text

Abstract:

Abstract Background: We examined patient-reported symptomatic adverse events (AEs) prior to trial start, and their association with concurrent global health status, health utilities and clinical factors in patients enrolled in early-phase trials combining immune checkpoint blockade with other anticancer therapy. Methods: Within 2 weeks prior to trial start, patients consented to begin an early phase trial of a combination treatment including at least 1 immune checkpoint inhibitor completed validated items of the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse E

APA, Harvard, Vancouver, ISO, and other styles

49

Carter, Bing Z., Po Yee Mak, Baozhen Ke, et al. "Selective Targeting of TP53-Y220C Mutant AML By PC14586 Results in TP53 Wild-Type Conformation and Synergistical Apoptosis Induction By Concomitant Inhibition of Xpo-1, MDM2, or Bcl-2." Blood 142, Supplement 1 (2023): 2261. http://dx.doi.org/10.1182/blood-2023-181186.

Full text

Abstract:

Patients with TP53-mutant acute myeloid leukemia (AML) constitute the worst outcome group with a survival of only several months. TP53 mutations frequently become dominant following exposure to chemotherapeutic agents, Bcl-2 or MDM2 inhibitors, and confer resistance to multiple other therapies. Y220C is a recurrent hotspot TP53 mutation observed in solid tumors and hematological malignancies, predominantly in AML and MDS (Gener-Ricoset al., ASH 2022). PC14586 (PMV Pharmaceuticals) is designed to bind to the p53-Y220C mutant and restore wild-type (WT) p53 protein conformation and function. PC14

APA, Harvard, Vancouver, ISO, and other styles

50

Davidson, Tara M., Jason Roszik, Lei Kang, et al. "Abstract B002: Clinical Trial Diversity: Outcomes for US patients with advanced cancer in Phase 1 clinical trials at a major cancer center." Cancer Epidemiology, Biomarkers & Prevention 32, no. 12_Supplement (2023): B002. http://dx.doi.org/10.1158/1538-7755.disp23-b002.

Full text

Abstract:

Abstract Background: Clinical trials should be equally accessible; however, multiple populations continue to be underrepresented in all phases of cancer clinical research due to interrelated economic, cultural, social, and medical barriers. Insight into how residing in rural areas, geographic distance to trial sites, race, and gender each affect patient enrollment and outcomes in early phase cancer trials will inform addressing these barriers. Methods: Reviewed EMR data for all patients with advanced cancer (&gt; 18 years of age) who consented to at least one clinical trial at a single ins

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!