Academic literature on the topic 'Dynamics of extraction of biologically active substances'
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Journal articles on the topic "Dynamics of extraction of biologically active substances"
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Ovsyannikov, V. Yu, and D. E. Drannikova. "STATUS AND PROSPECTS OF ULTRASONIC EXTRACTION OF BIOLOGICALLY ACTIVE SUBSTANCES." AGRO-INDUSTRIAL TECHNOLOGIES OF THE CENTRAL RUSSIA 1, no. 27 (2023): 52–63. http://dx.doi.org/10.24888/2541-7835-2023-27-52-63.
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The features of ultrasonic action on biotechnological raw materials of plant and animal origin during the extraction of useful components are considered. The mechanism of the energy impact on the raw material, the sound field solvent, as well as the influence of regime parameters on the main characteristics of the process, is described. The positive dynamics of the complex wave and diffusion effects on the nature and yield of biological substances from plant materials is shown. The performed studies on the extraction of rennet from crushed calf abomasum’s showed an increase in the temperature of the sonicated medium by 13°C and a change in pH due to the formation of H+ and OH– radicals due to cavitation. It has been estab-lished that during the first 4 minutes of sonicating a mixture of crushed calf abomasum’s and a solvent, the pH value of the solution decreases slightly, and subsequently changes to the opposite after the 5th mi-nute. This is followed by a second decline after 20 minutes and scoring. This phenomenon was explained by the formation of a significant amount of HCl free radicals within a microsecond sonication interval, af-ter which a change in the reaction to the reverse was noted. The prospects for research in this area from the point of view of further improvement and development are shown.
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Bazhenova, B. A., S. Yu Leskova, R. A. Dobretsky, I. A. Khankhalaeva, D. V. Shalbuev, and B. Kong. "Effect of blueberry (<i>vaccínium myrtíllus</i>) leaves extract, obtained by microwave heating on the dynamics of animal fat oxidation processes." Theory and practice of meat processing 8, no. 2 (2023): 124–31. http://dx.doi.org/10.21323/2414-438x-2023-8-2-124-131.
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The potential of antioxidant properties of blueberry leaves extract (vaccínium myrtíllus) that grows in the Trans-Baikal region has been studied in this work. In order to increase the efficiency of extraction of biologically active substances with antioxidant properties, this extract was obtained with the help of microwave field. The optimal parameters for the extraction of active substances from the blueberry leaves with the help of electromagnetic microwave field have been defined. The influence of the power of the electromagnetic field and the duration of the process of blueberry leaves extraction on the efficiency of extraction of biologically active polyphenolic substances has been studied. The following parameters of the technology for blueberry leaves extraction were obtained: extraction with a water-alcohol solution with a concentration of 40% in the ratio of raw materials to extractant as 1 to 5, with duration of stirring as long as 30 minutes, then the application of an electromagnetic field of microwave heating with a power of 850W for 8–10 minutes long. Blueberry leaves extract is a clear liquid with a high content of polyphenols, of rich brown color, tart taste, without bitterness. The antioxidant potential of the obtained extract has been studied. To do this, the extract has been added into the finely ground animal fat and left for storage in a closed dark container. During storage, the dynamics of the peroxide number has been measured, as this value characterizes the degree of lipid oxidation. It has been found that blueberry leaves extract inhibits the process of animal fat oxidation due to the action of biologically active substances that feature antioxidant properties.
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Iryna, Dyachok, Pinyazhko Oleh, and Ivankiv Oksana. "Dynamics of exception of organic acids from mixture of medical vegetable raw material." ScienceRise: Pharmaceutical Science, no. 3(13) (June 29, 2018): 37–42. https://doi.org/10.15587/2519-4852.2018.135874.
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<strong>Aim.</strong> Obtaining the mathematical equations for calculating the size of the parts to which different morphological organs of medicinal plants are to be chopped in order to achieve a required degree of extraction of biologically active compounds when they are extracted simultaneously. <strong>Methods.</strong> Looking at the increasing trends of the level of psychopathological disorders, it is expedient to develop and introduce into medical practice sedatives which is based on complex phytopolyextracts, obtained from medicinal vegetable raw materials permitted for medical use. Modern data about the chemical ingredients, pharmacological effect, application in world medical practice allow us to positively evaluate the trends of using the medicinal vegetable raw materials for the preparation of phytopolyextracts of sedative meditinal. Growing requirements for the quality of medicinal products of plant origin are a prerequisite for the development of advanced methodologies for the production of phytopolyextracts. <strong>Result.</strong> The results of research into the development of a methodology for the analytical calculation of the particle size of plant raw materials of various morphological organs to simultaneously achieve a given degree of extraction of organic acids and other biologically active substances during joint extraction are presented. <strong>Conclusions.</strong> The obtained mathematical equations describe the dynamics of extraction of organic acids from medicinal vegetable raw materials. Solving the system of obtained mathematical equations allows to calculate the size to which the vegetable raw materials of different morphological organs should be grinded in order to simultaneously achieve a given degree of extraction with joint extraction the mixture of medicinal vegetable raw materials. The obtained results represent the benefits from research of joint extraction of medicinal vegetable raw materials to obtain natural biologically active substances for the manufacture of multicomponent phytopreparations
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Dyachok, Vasyl, Liubov Venher, Oksana Ivankiv, and Iryna Diachok. "DEVELOPMENT OF ENVIRONMENTALLY SAFE TECHNOLOGIES FOR THE EXTRACTION OF PLANT RAW MATERIALS." Environmental Problems 8, no. 1 (2023): 31–36. http://dx.doi.org/10.23939/ep2023.01.031.
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The peculiarity of solid bodies of organic origin, in contrast to solid bodies of mineral origin, is that their internal structure is characterized by the presence of two spaces - cellular and intercellular. Such bodies tend to swell upon contact with the extractant. The phenomenon of swelling, during extraction, is always accompanied by the dissolution of target substances contained in the cellular and intercellular space. All these processes create conditions for the diffusion of the dissolved target substance through the cell membrane into the intercellular space, and then through the intercellular space beyond the boundaries of the solid phase particle. This helps to increase the volumes of the cellular and intercellular environment. The absolute value of the volumes of cellular and intercellular spaces is one of the most important values when developing and calculating extraction processes and forecasting environmentally safe technologies for obtaining biologically active compounds. The work presents a method of experimentally calculating the volumes of intercellular and cellular spaces of medicinal plant raw materials of various morphological organs. The established absolute values of the volumes of the cellular and intercellular spaces make it possible to calculate the order of diffusion coefficients of biologically active compounds in the medium of the intercellular space, as well as in the cell membrane. In the future, the determined values of the volumes provide grounds for predicting the regime, kinetics and dynamics of extraction of target substances during the implementation of an environmentally safe technology for obtaining biologically active compounds in production, as well as to support the monitoring of production processes of extraction in digital mode.
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Школьникова, Марина, Marina Shkol’nikova, Игорь Бакин, et al. "Extracting Vitabiotic Pharmaceutical Substances from Berry Raw Materials: Optimization of Processes." Food Processing: Techniques and Technology 48, no. 4 (2019): 121–30. http://dx.doi.org/10.21603/2074-9414-2018-4-121-130.
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The research features new processing methods of extraction of active antibacterial components from Siberian berries. The paper describes the content of biologically active agents and antibacterial dynamics in blackcurrant (Ribes nigrum L.) and common sea buckthorn (Hippophae rhamnoides L.) extracts. The study involved an analysis of the bactericidal biologically active agents in the extracts. The experiment revealed the main effect and synergism of the principal components, i.e. flavonoids, tannins, and vitamin C. It also established the leading role of the phenolic substances (flavonoids, tannins, phenolic acids, and glycosides) in the antibacterial influence on cultures of some kinds of pathogenic, potentially pathogenic, and unwanted microflora. The authors revealed some regularities of useful substances extraction in the conditions of ultrasonic processing. The optical density indicator of extracts during extraction helped to establish the optimum parameters of the process: mash ratio – 1:15; ultrasonic exposure frequency – 22 kHz. The experiment determined the mass fraction of extractive substances and active components, as well as the values of extraction coefficients of the berry raw material. Tannins and vitamin C were more extractable than flavonoids. The research also touched upon the impact of ultrasonic processing on the acceleration of extraction. When processing water-alcohol solutions of the raw material by ultrasonic irradiation with an intensity of 2 W/cm2 and a frequency of 22 kHz, the extraction duration fell from 300 to 15–20 minutes before the comparable values of balance concentrations of extractives were reached, in comparison with the control samples.
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Vasilevskaya, E. R., M. A. Aryuzina, and E. S. Vetrova. "Comparative study of technologies for extraction of biologically active substances from the raw material of animal origin." Theory and practice of meat processing 6, no. 3 (2021): 226–35. http://dx.doi.org/10.21323/2414-438x-2021-6-3-226-235.
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Technologies of isolation and concentration of biologically active substances, developed in the middle of the 20th century, need adjustment and adaptation to modern conditions both to increase the activity of substances and for greater economic efficiency. The aim of the research is the comparison of dynamics of biologically active compounds extraction from porcines pancreas in two methods: the saline method based on 0.9% sodium chloride solution, and the acidic method based on 2.4% trichloroacetic acid solution. Also the purpose of research is to assess the possibilities for further optimization of technologies. The total protein concentration based on the biuret reaction in the samples taken during the extraction, as well as the calculation and analysis of the point degrees and rates of extraction are chosen as the controlled parameters. Local maxima of the protein yields into the extractant media at the 60th, 135th and 255th minute were recorded during saline extraction; and at the 75th and 135th minute during acid extraction. Also the proteomic profile of the extracts was studied. Wide range of compounds with molecular weight of less than 52 kDa was found in extracts based on physiological saline solution, and protein substances of whole presented range of molecular weights in trichloroacetic acid based extracts were considered. The predominance of low molecular weight protein fraction of interest was noted also in this method of extraction in comparison with the other methods of extraction. According to the UniProt database, we assume availability of probable compounds with a molecular weight of less than 30 kDa in the purified acidic extract. The presence of some proteins absent in the final saline extract was noted. The acidic erythrograms showed a weak degrading effect of both types of extracts on the membranes of rat erythrocytes, as well as the cytoprotective effect of acidic ultrafiltrates (less than 3 kDa). The obtained results prove a better efficiency of trichloroacetic acid extraction method used for obtaining a mixture of a wide range of compounds, including biologically active substances of low molecular weight.
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Chaika, N. B., M. A. Komisarenko, O. M. Koshovyi, A. M. Kovaleva, and N. V. Borodina. "RESEARCH IN THE DYNAMICS OF BIOLOGICALLY ACTIVE SUBSTANCES EXTRACTION FROM THE ARCTOSTAPHYLOS UVA-URSI LEAVES." Fitoterapia 4, no. 4 (2019): 64–68. http://dx.doi.org/10.33617/2522-9680-2019-4-64.
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Nilova, L. P., S. M. Malyutenkova, and V. R. Tverskoy. "Dynamics of biologically active compounds and antioxidant activity of coffee during cold extraction at different temperatures." New Technologies 20, no. 4 (2025): 35–44. https://doi.org/10.47370/2072-0920-2024-20-4-35-44.
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Introduction. Cold brewing is a relatively new method of preparing coffee. The goal research was to study the dynamics of biologically active compounds and antioxidant activity during cold extraction of coffee using Arabica coffee sold on the Russian consumer market. The Methods. Extraction was carried out for 24 hours in two versions differing in the temperature of the water for extraction (+20 °C and +4 °C). At different time intervals (5 minutes, 1, 3, 6, 12 and 24 hours) the following were determined in the extracts: spectrophotometrically for caffeine content, the amount of chlorogenic acids, phenolic compounds; antioxidant activity by the coulometric method. The coffee extract brewed in a French press for 5 minutes using the hot method served as a control sample. The Results. The main part of biologically active compounds passed into the extract after 6 and 12 hours when using water at a temperature of +20 °C and +4 °C for extraction, respectively, constituting more than 90 and 95 % of their total amount extracted in 24 hours. At the same time, their antioxidant activity was only 83.89 and 87.45 %. The content of biologically active compounds and the antioxidant activity of the extracts reached or exceeded the control after 24 hours of extraction. In drinks prepared for 6 and 24 hours (water temperature +20 °C) and 12 and 24 hours (water temperature +4 °C), soluble dry substances, pH, titratable acidity, and brown color intensity were additionally determined. At a higher temperature, coffee acquires a bitter taste during 24 hours of extraction, which reduces its organoleptic assessment. The Conclusion. To form optimal organoleptic and antioxidant properties when preparing Arabica coffee using cold brewing method, water at a temperature of +20 °C and +4 °C can be used with an extraction time of 6 and 24 hours, respectively.
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Belokurov, S. S., E. V. Flysyuk, and I. E. Smekhova. "Choice of Extraction Method for Receiving Extraction from Seeds of Payne Hay with the High Content of Biologically Active Substances." Drug development & registration 8, no. 3 (2019): 35–39. http://dx.doi.org/10.33380/2305-2066-2019-8-3-35-39.
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Introduction. According to the literature, modern technologies, in particular, extraction in an ultrasonic field, make it possible to obtain concentrates of biologically active substances (BAS) with almost complete preservation of the chemical composition inherent in natural raw materials and high yield of extractive substances. At the same time, the ability to regulate the concentration of recoverable active substances during the technological process opens up prospects for the use of natural components as the main pharmaceutical substance.Aim. The purpose of this study was to select the optimal extraction method for obtaining extracts with a high content of BAS from fenugreek seeds. Materials and methods. Extracts were obtained at a temperature of 60±2 °С, by the method of dynamic maceration using an ultrasonic device. Ultrasonic extraction was performed using an ultrasonic installation I100-6/4. In both cases, purified water and ethanol solutions in various concentrations from 40 to 90% were used as extractants. The ratio of raw materials: extractant was as 1:10 (by weight). A portion of vegetable raw materials (10 g) was placed in a glass and poured 100 cm3 of extractant. Next, maceration or sonication was performed. Maceration was performed with magnetic stirring, the rotation speed was 100 rpm. Extraction was carried out at a temperature of 55–60 °C for 5 hours. Ultrasonic effects on solid plant materials were carried out with an intensity in the range from 17 to 22 kHz for 30–60 minutes.Results and discussion. Studies have allowed to determine the amount of extractives in the seeds of fenugreek hay, and choose the most promising method of extraction to obtain extracts with a high content of biologically active substances. A comparison was made between dynamic maceration and ultrasonic extraction. The most promising was the method of ultrasonic extraction at an oscillation frequency of 22 kHz. For 1 hour of extraction, it was possible to achieve depletion of raw materials. It is established that the content of extractable substances directly proportional depends on the duration of treatment and the frequency of ultrasonic waves. The correlation coefficient was 0.78.Conclusion. Ultrasonic extraction when exposed for 60 minutes allows you to get a greater amount of extractives compared with dynamic maceration. To achieve the same level of extractive substances by the method of dynamic maceration, the raw materials must be processed within 5 hours.
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Anna, Krvavych, and Konechna Roksolana. "Optimization of parameters of the extraction process of biologically active substances of grass Adonis vernalis." Technology audit and production reserves 3, no. 3(59) (2021): 14–18. https://doi.org/10.15587/2706-5448.2021.235471.
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<em>The object of this research is the herb Adonis vernalis and hydroalcoholic extracts obtained on its basis. By the nature of the action, the drugs Adonis vernalis belong to the group of cardiac glycosides and occupy an intermediate place between strophanthin and digitalis. In official medicine, biologically active compounds of Adonis vernalis are included in drugs such as Cardiovalen, Adonis-bromine, Caridiolin and Cardiophyte. In the extemporal formulation, the extract is part of the Bechterew’s medicine. Until recently, scientists have made significant progress in studying the phytochemical and pharmacological action of the herb Adonis vernalis. However, one should not be limited to the use of Adonis vernalis only for stimulating cardiac activity, one should also consider the promising antioxidant effect of flavonoids and phenolic compounds that are contained in this medicinal plant. Also, studies of the extraction conditions of the herb Adonis vernalis are not described in the scientific literature.</em> <em>The study carried out the extraction of the grass Adonis vernalis by various methods (static and dynamic). The type of extract was chosen as the most rational, which provides the maximum yield of extractives (phenolic compounds and cardiac glycosides). For this, the optimal extraction conditions were selected, namely, the particle size, the type of extractant, the value of the hydromodule and the extraction method. Accordingly, the optimal particle diameter for maximum extraction of biologically active substances of the herb Adonis vernalis is 2.5 mm, the optimal extractant is 70 % ethyl alcohol, the ratio of raw materials: extractant is 1:10, the optimal extraction method is maceration with constant stirring. Phytochemical studies of the quantitative composition of the main groups of biologically active substances were carried out using calorimetric and spectrophotometric methods of analysis.</em> <em>As a result of the optimization of the process and its introduction into production on an industrial scale, the value added effect will be achieved. And also a high-quality product has been created that will compete with broad-spectrum drugs already existing on the market.</em>
Dissertations / Theses on the topic "Dynamics of extraction of biologically active substances"
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Федоришин, Ольга Миколаївна. "Механізм та кінетика екстрагування біологічно активних речовин з рослинної сировини". Diss., Національний університет "Львівська політехніка", 2021. https://ena.lpnu.ua/handle/ntb/56691.
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Дисертацію присвячено вирішенню важливого науково-практичного завдання, що полягало у дослідженні процесу одержання фенольних сполук та флавоноїдів з рослинної сировини та оптимізації способів їх одержання з відкасника безстеблевого (Carlina acaulis), календули лікарської (Calendula officinalis), косариків черепитчастих (Gladiolus imbricatus), як потенційних лікарських засобів. В роботі досліджено особливості екстрагування біологічно активних речовин зазначених лікарських рослин. Розроблено спосіб одержання водно-спиртових екстрактів з рослинної сировини, як потенційних лікарських
засобів, проведено ідентифікацію фенольних сполук та флавоноїдів у об'єктах дослідження; досліджено екстракти лікарської рослинної сировини та досліджено їх якісний та кількісний склад. Вперше отримано кінетичні рівняння екстрагування фенольних сполук та флавоноїдів з відкасника безстеблевого (Carlina
acaulis), досліджено кінетичні закономірності екстрагування, встановлено умови процесу, що підтверджується динамікою накопичення фенольних сполук та флавоноїдів. Розраховано коефіцієнт дифузії фенольних сполук та флавоноїдів крізь клітинну стінку Ds, який лімітує процес, коефіцієнт дифузії у міжклітинному просторі DM, і показано, що його значення не залежить від розміру твердої фази та коефіцієнт дифузії в шарі екстрагенту De під час перемішування та настоювання. Вперше експериментально розроблено технологію одержання екстракту Carlina acaulis. Запропоновано принципову технологічну та апаратурно-технологічну схеми виробництва екстрактів. Дані
схеми в подальшому можна використовувати при підготовці технологічного процесу виробництва настоянок коренів Carlina acaulis. Оптимізовано процес за такими параметрами, як розмір частинок рослинної сировини, концентрація екстрагента та співвідношення сировина – екстрагент. The dissertation is devoted to solving an important scientific and practical problem. It consisted of the study of the process of obtaining phenolic compounds and flavonoids from plant raw materials and optimization of the process for their obtaining from Carlina acaulis, Calendula officinalis and Gladiolus imbricatus, as potential drugs. The peculiarities of extraction of biologically active substances of these medicinal plants are investigated in this work. The identification of phenolic compounds and flavonoids in the objects of research was carried out; a method for obtaining water-alcohol extracts from medicinal plant raw materials was developed, and their qualitative and quantitative composition as potential drugs was studied; optimal parameters of extraction of phenolic compounds and flavonoids are established. The kinetic equations extraction of phenolic compounds and flavonoids from Carlina acaulis was obtained for the first time, the kinetic regularities of extraction are investigated, the conditions of the process are established, which is confirmed by the dynamics of accumulation of phenolic compounds and flavonoids. The diffusion coefficients of phenolic compounds and flavonoids through the cell wall were calculated Ds. Detected that diffusion coefficients Ds limit the process. The
diffusion coefficient in the intercellular space DM were calculated, and it is shown that its value does not depend on the size of the solid phase. The diffusion coefficient in the layer of extractant De during mixing and infusion also were calculated. For the first time, the technology of obtaining Carlina acaulis extract was experimentally developed. The basic technological and hardware-technological schemes of production
of extracts are offered. These schemes can then be used in the preparation of the technological process of production of tinctures of the roots of Carlina acaulis. The process is optimized for such parameters as the particle size of plant raw materials, the extractant concentration and the raw material - extractant ratio.
Book chapters on the topic "Dynamics of extraction of biologically active substances"
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Mauli, Marcia M., Adriana M. Meneghetti, and Lúcia H. P. Nóbrega. "Terpenes Behavior in Soil." In Terpenoids: Recent Advances in Extraction, Biochemistry and Biotechnology. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9781681089645122010010.
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Soil is a complex and dynamic system in constant change due to its natural processes, as well as interaction among physical, chemical and biological characteristics that take part in it. However, the greatest transformation occurred due to the farm business and the adopted management system. Thus, man can manipulate some soil characteristics and make it more suitable for cropping development. Although anthropic action cannot fully control how soil characteristics interact, it is possible to track them. The action of chemical substances should not be disregarded, a product of the secondary metabolism of plants, since they interfere with plant's ability to compete and survive. Such substances can act out as protectors against herbivores and pathogens. They can be attractive or repellent agents in plant-plant competition and plant-microorganism symbiosis. They can also influence the interaction between plant matter and soil organisms. Among these substances, terpenoids are highlighted as the most structurally diverse chemical family in the class of secondary metabolites that are part of natural products. This knowledge allows a better understanding of nutrient decomposition and cycling processes, the influence of environmental factors on production and terpenoid variability in some plants with medicinal and economic importance.
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Karpov, S. I., L. A. Sinyaeva, N. A. Belanova, et al. "PROSPECTS OF THE SYTHESIS AND APPLICATION OF MESOPOROUS NANOSTRUCTURED MATERIALS FOR EXTRACTION OF BIOLOGICALLY ACTIVE SUBSTANCES." In To the 100th anniversary of I.G. Yudelevich. Works of analytical chemists. NIIC SB RAS, 2020. http://dx.doi.org/10.26902/udl2020_12.
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Saxena, Abhishek, Aditi Raj, and Archana Tiwari. "Exploring the Anti-cancer Potential of Microalgae." In Progress in Microalgae Research - A Path for Shaping Sustainable Futures. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104831.
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Cancer, the deadliest disease in the world, is taking away the lives of millions of people. The disease and its property of metastasis are still understudied. Various therapies have been discovered to cure this malignancy, but nearly all of them introduce a lot of side effects. Therapies such as radiation, chemotherapy, surgery, etc., are in vogue but are not so economical and approachable for many needy people. Since the nature of cancerous cells is very complex among different individuals, it becomes even more complex to treat them. In modern times, biologically active compounds extracted from plants, weeds, and, most importantly, algae (marine drugs) found in the sea have proved to possess excellent anti-cancer potential. However, the major bottlenecks are the extraction of active substances in ample quantity with high quality. This chapter describes the role of microalgae as anticancer agents. Several aspects of bioactive compounds and challenges linked to microalgae will be discussed. A brief account of nanotechnology and its role in the treatment of cancer in the context of microalgae will be highlighted. The level of algal properties that affect cell proliferation, cell arrest, and apoptosis is elaborated. The current scenario of this investigation is extensively discussed in the study, along with the chemical structure, pros and cons.
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Eberle, Lidiia, and Alona Kobernik. "PHARMACOLOGICAL STUDY OF OINTMENT BASED ON ZINGIBER OFFICINALE EXTRACT." In European vector of development of the modern scientific researches. Publishing House “Baltija Publishing”, 2021. http://dx.doi.org/10.30525/978-9934-26-077-3-20.
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Nonsteroidal anti-inflammatory drugs such as ibuprofen and diclofenac sodium are widely known drugs for the treatment of inflammatory reactions. Prolonged use of drugs inevitably leads to the development of adverse reactions and reduced immunity of patients. Since the reduction of the "drug load" is an urgent task in this situation, an alternative direction to solve it is the use of natural therapeutic factors, the rehabilitation capabilities of which in these conditions are very appropriate and effective. There is a whole arsenal of medicinal plants in the world, they contain a complex of biologically active substances and are not inferior in therapeutic properties to synthetic agents. Among such medicinal plants is Zingiber officinale, which for the past 10 years is actively grown in Ukraine in the city of Kherson. The study shows the relevance of making a mild drug based on a thick extract of the rhizome of Zingiber officinale. It is proved that the extract belongs to low-toxic compounds, which allows its use in the composition of drugs for transdermal administration. An ointment was made on the basis of a thick ginger extract with a content of biologically active substances of 0.025%. The content was standardized according to the content of the sum of polyphenolic compounds. Inflammation was induced by subplantar injection to the plantar fasciitis (aponeurosis) of the hind limb of rats using 30 µL AITC solution (100 µg/limb) in 1,2-propyleneglycol. The dynamics of changes of inflammatory process was evaluated before addition of the inflammation inducer and after 1, 2, 3, 4, 6 and 24 hours of its injection for measuring the volume and the thickness of affected limb. Ointment based on ginger extract has a high level of anti-inflammatory properties, which is shown on the basis of the positive dynamics of changes in the morphological parameters of the affected limbs of animals. Prophylactic application of the phytopreparation two days before the start of the experiment helped to block the development of inflammation in comparison with the control group and the reference drug – ibuprofen ointment. The soft dosage form created and studied by us based on the thick extract of Zingiber officinale is an effective anti-inflammatory agent that can not only treat inflammation, but also block its development under previous prophylactic applications.
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Bozhko, Nataliia, and Vasyl Tischenko. "EFFECT OF PLANT EXTRACTS RICH IN POLYPHENOLS ON LIPID OXIDATION IN SMOKED SAUSAGES." In The scientific paradigm in the context of technological development and social change. Publishing House “Baltija Publishing”, 2023. http://dx.doi.org/10.30525/978-9934-26-297-5-20.
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Meat products are subject to degradation processes. Among them, the most important after microbial destruction are oxidative processes that affect lipids, pigments, proteins and vitamins. Lipid oxidation is a major non-microbial cause of deterioration in meat and meat products. The purpose of the study is a theoretical and experimental study of the content of bioflavonoids (phenolic substances) in berry extracts and their use in systems of biological origin to inhibit oxidative processes during storage. Methodology of the study is based on theoretical research of sources for the concentration of biologically active substances, including secondary metabolites of plants (bioflavonoid complex), in berries and on experimental studies of the dynamics of oxidative processes in food products with a high content of lipids according to indicators such as acid value, peroxide value, thiobarbiturate value using titrometric and colorimetric methods of analysis. Results. The work theoretically analyzes information on the high content of phenolic substances in black chokeberry (Aronia melanocarpa) and black currant (Ribes nigrum L.), which determines their high antioxidant properties and proves the prospect of using them as natural antioxidant additives in meat and meat technology meat products. The study experimentally proved the high antioxidant activity of black chokeberry and black currant extracts in smoked sausage technology. With the addition of black rowan and black currant extracts, inhibition of peroxidation is observed already after the first 5 days of storage. It was found that the addition of black chokeberry extract in the amount of 0.2-0.5% to the mass of minced meat significantly slows down the hydrolytic oxidation of lipids in the finished product, effectively suppresses the peroxidation of fat and stabilize the formation of secondary products of oxidation during the storage of smoked sausages with a high fat content. A microbiological safety study of experimental sausages during storage was conducted. Practical implications. Extracts of black chokeberry and black currant can be successfully used in the production technology of smoked meat and meat-containing sausages of a multicomponent composition for inhibition of lipid oxidation during the storage and preventing of spoilage of products. Value/originality. The effectiveness of this method is improving of smoked sausage quality with natural antioxidants such as black chokeberry (Aronia melanocarpa) and black currant (Ribes nigrum L.) extracts due to high content of phenolic compounds, which replace potentially harmful synthetic antioxidants.
Conference papers on the topic "Dynamics of extraction of biologically active substances"
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Strautins, Uldis, and Maksims Marinaki. "On modelling of three dimensional flow in extraction of biologically active substances from plants." In 22nd International Scientific Conference Engineering for Rural Development. Latvia University of Life Sciences and Technologies, Faculty of Engineering, 2023. http://dx.doi.org/10.22616/erdev.2023.22.tf039.
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The authors consider the process of extraction from heterogeneous plant material; a novel model offering 3D spatial resolution is proposed and simulation possibilities by applying several modern numerical methods for three dimensional problems are discussed. These types of problems naturally arise when one wishes to mathematically describe the processes of the extraction with solvents such as supercritical carbon dioxide (scCO2). The results of this process meet the demand of the functional foods, nutraceutical, pharmaceutical and cosmetic industries on bioactive compounds. The models used in typical simulations by the industry offer no spatial resolution of the extraction process, however, when novel designs of extractors are developed, the three dimensional flow of the solvent and its interaction with the plant material should be considered. We propose a coupled system of equations consisting of fluid dynamics equations describing the flow of the solvent and reaction-advection-diffusion equations for the solute, plus equations describing the remaining concentration of solute in the biomass. The exchange of the active material between the solid and fluid is modelled by the Langmuir law. The initial distribution of solute in the plant material is not assumed to be homogeneous, nor are the extraction parameters, i.e. heterogeneous mixture of plant materials can be covered by this model. The equations are discretized by using finite volume techniques and currently implemented in Octave/Matlab environment. As a result, the temporal evolution of the three dimensional distribution of the solute is obtained along with the velocity field of the solvent, allowing detailed studies of the extraction process in a virtual design. The model is modular, allowing integrating tailor-made laws to describe various plant materials. The authors present simulation results and analyse the advantages and disadvantages of the proposed methods and approaches.
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Ulrikh, E. V., O. V. Smolovskaya, and A. Yu Kolbina. "Methods for extraction of biologically active substances from Amaranth." In MODERN APPROACHES IN ENGINEERING AND NATURAL SCIENCES: MAENS-2021. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0116767.
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Abdullina, D., K. Valeev, and R. Safin. "ENERGY RESOURCE-SAVING PLANT FOR EXTRACTION OF BIOLOGICALLY ACTIVE SUBSTANCES." In Modern machines, equipment and IT solutions for industrial complex: theory and practice. FSBE Institution of Higher Education Voronezh State University of Forestry and Technologies named after G.F. Morozov, 2021. http://dx.doi.org/10.34220/mmeitsic2021_175-179.
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As know, all wood material is recycled only half, and the rest of it remains unused. In practice, wood waste is most often plowed or burned, at a time when such wood is a valuable natural raw material that can compensate for the needs of a number of sectors of the economy. In this regard, the problem of recycling waste from the woodworking industry is very relevant today. Wood waste contains a large amount of substances capable of exhibiting biological activity. In particular, such biologically active substances include betulin, which is found in birch bark, which, due to its many advantages, has found wide application in medical, perfumery, cosmetic, food and other industries. For the rational use of wood and wood materials, it is necessary to develop new technologies and equipment for processing wood into products that are in demand for mankind. The paper provides an overview of the processing of birch bark. The relevance and prospects of birch species as a raw material for the chemical industry have been established. An installation for obtaining biologically active substances from wood waste is presented.
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Korotkiy, I. A., E. V. Korotkaya, and A. D. Tiunin. "DENSITY OF CARBON DIOXIDE FOR SUPERCRITICAL EXTRACTION OF BIOLOGICALLY ACTIVE SUBSTANCES." In Инновационное развитие агропромышленного, химического, лесного комплексов и рациональное природопользование. НовГУ им. Ярослава Мудрого, 2023. http://dx.doi.org/10.34680/978-5-89896-873-1/2023.innovation.36.
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Petrova, A. A., and A. V. Salishcheva. "MODERN TECHNOLOGIES FOR THE EXTRACTION OF BIOLOGICALLY ACTIVE SUBSTANCES FROM PLANT RAW MATERIALS." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-93.
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Modern methods of extracting biologically active substances from various raw materials are focused on the efficiency and environmental friendliness of the process. The brief description of biologically active substances, advantages and disadvantages of extraction methods and their characteristics were described.
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Kore, Akansha, Neelaambhigai Mayilswamy, and Balasubramanian Kandasubramanian. "Molecular dynamics study of polymeric drug systems." In INTELLIGENT BIOTECHNOLOGIES OF NATURAL AND SYNTHETIC BIOLOGICALLY ACTIVE SUBSTANCES: XIV Narochanskie Readings. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0179236.
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Safina, A. V., K. V. Valeev, and R. G. Safin. "Mathematical description of the process of extraction of biologically active substances from larch wood." In INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “TECHNOLOGY IN AGRICULTURE, ENERGY AND ECOLOGY” (TAEE2022). AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0127439.
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Mohanta, Susmita, and Sidhartha S. Jena. "Influence of embedded polyelectrolyte on the structure and dynamics of polyacrylamide hydrogels." In INTELLIGENT BIOTECHNOLOGIES OF NATURAL AND SYNTHETIC BIOLOGICALLY ACTIVE SUBSTANCES: XIV Narochanskie Readings. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0179222.
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Padhee, Ipsita, and Sidhartha S. Jena. "Effect of polymer concentrations on structure and dynamics of Gellan gum hydrogels." In INTELLIGENT BIOTECHNOLOGIES OF NATURAL AND SYNTHETIC BIOLOGICALLY ACTIVE SUBSTANCES: XIV Narochanskie Readings. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0178677.
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Devi, P. Nirmala, K. Manoj Senthil, and M. Pavithra. "An efficient content based image retrieval and classification based on hybrid texture feature extraction." In INTELLIGENT BIOTECHNOLOGIES OF NATURAL AND SYNTHETIC BIOLOGICALLY ACTIVE SUBSTANCES: XIV Narochanskie Readings. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0178562.
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