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Journal articles on the topic 'Dysfunctional protest'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Mistygacz, Michał, and Anna Materska-Sosnowska. "Dysfunkcjonalność protestów wyborczych w Polsce w świetle standardu uczciwych wyborów." Przegląd Prawa Konstytucyjnego 75, no. 5 (2023): 191–203. http://dx.doi.org/10.15804/ppk.2023.05.14.

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Fair elections are one of the foundations of electoral axiology in a democratic state ruled by law. Every citizen has the right to protest, and the justification of the citizen’s complaint is the public interest. An election protest is a legal measure to control the held General elections and its purpose is to protect the public interest in the electoral process. The standard of fair elections is not only a context for legal solutions strictly derived from the Constitution or the Electoral Code. The juridical architecture of electoral protests in Poland generally creates an effective mechanism

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Eneni, Roberts Ofrey, and bada Oluchi Vincent Ogbumg. "Remediating youth restiveness using social entrepreneurship education." GPH-International Journal of Educational Research 7, no. 11 (2025): 90–108. https://doi.org/10.5281/zenodo.14621293.

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Youth restiveness has been on the increase in almost every community in Nigeria. This has contributed to massive loss of lives and properties, which constitute a major threat to security of the state and its corporate existence. The aim of this research was to examine the relationship between Social Entrepreneurship (SE) andYouth Restiveness (YR). The study followed the pragmatic philosophical paradigm combining both the inductive and the deductive methods of scientific inquiry in a cross-sectional survey. A systematic random sampling was adopted to collect datafrom308 youths that werebetween

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POOLE, STEVE. "‘A lasting and salutary warning’: Incendiarism, Rural Order and England's Last Scene of Crime Execution." Rural History 19, no. 2 (2008): 163–77. http://dx.doi.org/10.1017/s0956793308002471.

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AbstractAgricultural incendiarism was a perennial factor in social relations in some areas of nineteenth-century rural England and is often understood by historians as an expression of ‘covert’ social protest. However, such categorisation risks oversimplifying what may be diverse and locally specific factors. In 1830, the high sheriff of Somerset presided over England's last ever scene of crime execution at the Somerset village of Kenn following the conviction of three labourers for incendiarism. This requires explanation. Crime scene executions were not only anachronistic and rare, but unfash

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Snyder-Young, Dani. "The Promise and Pitfalls of the Real." Theatre Survey 57, no. 3 (2016): 424–31. http://dx.doi.org/10.1017/s0040557416000442.

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Audience members sit at tables and desks in an interactive classroom, an immersive performance space designed to evoke a K–12 classroom. Blackboards are covered with homework assignments and test reminders, posters with test-taking tips and motivational quotes such as “For success, attitude is as important as ability.” Collaboraction's production of Forgotten Future: The Education Project begins as an interracial, intergenerational ensemble of actors enters the space chanting and waving signs reading “Support our Schools: Don't Close Them” and “Save our Schools” in protest of Chicago's dysfunc

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Pustovoyt, Yurii. "PROTEST IN THE CITIES OF SIBERIA: THE EXPERIENCE OF MEASURING FACTORS OF MOBILIZATION ACTIVITY." Вестник Пермского университета. Политология 14, no. 3 (2020): 122–30. http://dx.doi.org/10.17072/2218-1067-2020-3-122-130.

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The paper considers a set of conditions that stimulate mobilization activity. Based on the J. Goldstone’s fourth-generation revolution model, the author proposes such stimuli: the effectiveness of government, the dissatisfaction and the elites, and the protesters' notion of the power. The author reviews protesting regions’ capitals with these factors based on the assessment of mobilization. The preliminary results show that the higher the level of urban prosperity and of formal competition, the higher the mobilization activity and the ability of protest communities to establish control over re

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Neshev, Petar. "Domestic Violence, Family Relationships and Problem Behavior in Childhood and Adolescent Age." Педагогически форум 11, no. 1 (2023): 31–40. http://dx.doi.org/10.15547/pf.2023.004.

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The article examines the causes of domestic violence and the relationship between family relationships and problematic behavior in childhood and adolescence. The influence of different types of parenting models on child development is presented. The symptoms of the dysfunctional family are indicated. Domestic violence and faulty parenting patterns can lead children and adolescents to traumatic experiences and sufferers should be given support and professional help. The psychological specificity of different types of family relationships has been revealed. In family relationships with prevailin

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Adeyemi, Amos ADEGBOYEGA. "Protest, Democracy and Social Development in Nigeria: Reflections on Contemporary Nigerian Writings." International Journal of Academic Research in Business, Arts & Science ( IJARBAS.COM ) 1, no. 4 (2020): 51–71. https://doi.org/10.5281/zenodo.3598132.

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Literary productions from Nigeria since inception have envisioned a utopian society. Driven by protest to foster sociopolitical development, the literary artist from the days of Chinua Achebe in <em>Things Fall Apart</em>** engaged in and has remained relevant to emerging trends of discourses in Nigeria. While forebear nationalists protested against colonial incursions and the attending destabilization of the hitherto organized Nigerian society, contemporary postcolonial writers contend with realities militating against the nation’s fragile democracy. Their creativities beyond entertainm

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Gabsi, Zouhir. "Rap and Mizoued Music: Claiming a Space for Dissent and Protest in Post-Arab Spring Tunisia." Sociological Research Online 25, no. 4 (2020): 626–43. http://dx.doi.org/10.1177/1360780419898494.

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The Arab Spring in Tunisia has brought with it positive changes, such as freedom of expression and democracy. However, Tunisians have found that these applauded achievements have not improved their living conditions. After Ben Ali was ousted in 2010, the decline of Tunisia’s economy was exacerbated by internal and external factors such as global recession, a dysfunctional liberal economy, internal political infighting, and corruption. To ventilate their frustration and dismay with the government and the overall socio-economic situation in Tunisia, some Tunisians turn to the music of rap and Mi

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Hemann, Michael T., Karl Lenhard Rudolph, Margaret A. Strong, Ronald A. DePinho, Lynda Chin, and Carol W. Greider. "Telomere Dysfunction Triggers Developmentally Regulated Germ Cell Apoptosis." Molecular Biology of the Cell 12, no. 7 (2001): 2023–30. http://dx.doi.org/10.1091/mbc.12.7.2023.

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Telomere dysfunction results in fertility defects in a number of organisms. Although data from fission yeast and Caenorhabditis elegans suggests that telomere dysfunction manifests itself primarily as defects in proper meiotic chromosome segregation, it is unclear how mammalian telomere dysfunction results in germ cell death. To investigate the specific effects of telomere dysfunction on mammalian germ cell development, we examined the meiotic progression and germ cell apoptosis in late generation telomerase null mice. Our results indicate that chromosome asynapsis and missegregation are not t

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10

Scanavino, Marco de Tubino. "Sexual Dysfunctions of HIV-Positive Men: Associated Factors, Pathophysiology Issues, and Clinical Management." Advances in Urology 2011 (2011): 1–10. http://dx.doi.org/10.1155/2011/854792.

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Sexual dysfunctions in HIV-positive men are associated with an increase in risky sexual behavior and decreased adherence to antiretroviral drug regimens. Because of these important public health issues, we reviewed the literature on the pathophysiology, associated factors and clinical management of sexual dysfunction in HIV-positive men. The goal was to investigate the current research on these issues. Literature searches were performed in June 2011 on PubMed, Web of Science, and PsycInfo databases with the keywords “AIDS” and “sexual dysfunction” and “HIV” and “sexual dysfunction”, resulting

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Kim, Eunkyeong, Jun Kim, Chuna Kim, and Junho Lee. "Long-read sequencing and de novo genome assemblies reveal complex chromosome end structures caused by telomere dysfunction at the single nucleotide level." Nucleic Acids Research 49, no. 6 (2021): 3338–53. http://dx.doi.org/10.1093/nar/gkab141.

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Abstract Karyotype change and subsequent evolution is triggered by chromosome fusion and rearrangement events, which often occur when telomeres become dysfunctional. Telomeres protect linear chromosome ends from DNA damage responses (DDRs), and telomere dysfunction may result in genome instability. However, the complex chromosome end structures and the other possible consequences of telomere dysfunction have rarely been resolved at the nucleotide level due to the lack of the high-throughput methods needed to analyse these highly repetitive regions. Here we applied long-read sequencing technolo

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Nisnevich, Y. "Public Mass Protest Promotions: Formation of an Inclusive Political Institute." World Economy and International Relations 66, no. 5 (2022): 120–34. http://dx.doi.org/10.20542/0131-2227-2022-66-5-120-134.

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This article analyzes the formation process of a new inclusive political institution, which is represented by public mass protests of a non-violent nature. Such actions, the number of which is constantly increasing, take place in states with both authoritarian and democratic governments, and they have become an institutionalized repertoire of political action under all types of government regimes. The socio-information environment, where social and info-communication processes are closely intertwined as a result of mass use of social networks, blogs and other Internet resources, as well as wid

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Bruells, Christian S., Karen Maes, Rolf Rossaint, et al. "Sedation Using Propofol Induces Similar Diaphragm Dysfunction and Atrophy during Spontaneous Breathing and Mechanical Ventilation in Rats." Anesthesiology 120, no. 3 (2014): 665–72. http://dx.doi.org/10.1097/aln.0000000000000125.

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Abstract Background: Mechanical ventilation is crucial for patients with respiratory failure. The mechanical takeover of diaphragm function leads to diaphragm dysfunction and atrophy (ventilator-induced diaphragmatic dysfunction), with an increase in oxidative stress as a major contributor. In most patients, a sedative regimen has to be initiated to allow tube tolerance and ventilator synchrony. Clinical data imply a correlation between cumulative propofol dosage and diaphragm dysfunction, whereas laboratory investigations have revealed that propofol has some antioxidant properties. The author

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Martínez, Eduardo, Julio Collazos, Jose Mayo, and Maria-Soledad Blanco. "Sexual dysfunction with protease inhibitors." Lancet 353, no. 9155 (1999): 810–11. http://dx.doi.org/10.1016/s0140-6736(99)00593-0.

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15

Colebunders, R., E. Smets, K. Verdonck, and C. Dreezen. "Sexual dysfunction with protease inhibitors." Lancet 353, no. 9166 (1999): 1802. http://dx.doi.org/10.1016/s0140-6736(05)75908-0.

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16

Sollima, Salvatore, Maurizio Osio, Francesco Muscia, et al. "Protease inhibitors and erectile dysfunction." AIDS 15, no. 17 (2001): 2331–33. http://dx.doi.org/10.1097/00002030-200111230-00020.

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17

Freiwald, Hannah Charlotte, Nico Peter Schwarzbach, and Anne Wolowski. "Effects of competitive sports on temporomandibular dysfunction: a literature review." Clinical Oral Investigations 25, no. 1 (2020): 55–65. http://dx.doi.org/10.1007/s00784-020-03742-2.

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Abstract Objectives The German Society of Craniomandibular Function and Disorders recommends that patients suffering from temporomandibular dysfunctions should practice sports in order to compensate for everyday stress. This raises the question as to what extent competitive athletes develop temporomandibular dysfunctions or whether their athletic activities protect them. With the present literature review, the authors intend to give an overview of the currently available publications on this topic. Materials and methods A literature research in the PubMed and Google Scholar databases was perfo

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Ezechi, Oliver Chukwujekwu, Folahanmi Tomiwa Akinsolu, Tititola Abike Gbajabiamila, et al. "Sexual dysfunction among Nigerian women living with HIV infection." PLOS ONE 19, no. 4 (2024): e0292294. http://dx.doi.org/10.1371/journal.pone.0292294.

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Introduction Sexual dysfunction in women with HIV is a necessary but understudied aspect of HIV complications in women living with HIV. This study reports the prevalence, pattern, and risk factors for sexual dysfunction in women living with HIV in southwest Nigeria. Methods A validated Female Sexual Function Index was used to determine sexual dysfunction in a cross-sectional study design involving 2926 adult women living with HIV in a large, publicly funded tertiary HIV treatment centre in Lagos, Nigeria. A score of less than 26.5 indicated sexual dysfunction. Multivariate logistic regression

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Amarjeet, Patel, Singh Bhawani, and Mishra K.N. "A Prospective Observational Assessment of the Serum Ferritin for Predicting Outcome in Children with Severe Sepsis in the Pediatric Intensive Care Unit." International Journal of Current Pharmaceutical Review and Research 15, no. 04 (2023): 25–32. https://doi.org/10.5281/zenodo.12635226.

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AbstractAim: The aim of the present study was to evaluate the prognostic ability of serum ferritinwhen estimated within 5 days of onset of illness in children with severe sepsis admitted to apediatric intensive care unit.Methods: The Present prospective and observational study was conducted in Department ofPaediatrics, DMCH, Darbhanga, Bihar, India. Study duration was of 1 year. Study wasstarted after obtaining approval from institutional ethics committee. In present study 50children satisfying study criteria were studied.Results: Boys (64%) were more than girls (36%) and mean age was 36.46 &p

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&NA;. "Rolofylline may PROTECT against renal dysfunction in AHF." Inpharma Weekly &NA;, no. 1633 (2008): 5. http://dx.doi.org/10.2165/00128413-200816330-00012.

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21

Karlsrud, John. "Responsibility to Protect and Theorising Normative Change in International Organisations: From Weber to the Sociology of Professions." Global Responsibility to Protect 5, no. 1 (2013): 3–27. http://dx.doi.org/10.1163/1875984x-00501002.

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How does normative change occur in international organisations (IOs)? The literature has theorised IO behaviour as being a consequence of the interest of powerful states, or has applied concepts borrowed from organisational sociology related to bureaucratic dysfunction, such as ‘dysfunctional behaviour’, ‘pathologies’, or ‘organised hypocrisy’. This article argues that using the sociology of professions can augment constructivist theorising of IO behaviour and offer a better understanding of normative change in IOs. The evolving norm of ‘Responsibility to Protect’ (R2P) has a significant impac

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Cammalleri, Maurizio, Massimo Dal Monte, Rosario Amato, Paola Bagnoli, and Dario Rusciano. "A Dietary Combination of Forskolin with Homotaurine, Spearmint and B Vitamins Protects Injured Retinal Ganglion Cells in a Rodent Model of Hypertensive Glaucoma." Nutrients 12, no. 4 (2020): 1189. http://dx.doi.org/10.3390/nu12041189.

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There is indication that nutritional supplements protect retinal cells from degeneration. In a previous study, we demonstrated that dietary supplementation with an association of forskolin, homotaurine, spearmint extract and B vitamins efficiently counteracts retinal dysfunction associated with retinal ganglion cell (RGC) death caused by optic nerve crush. We extended our investigation on the efficacy of dietary supplementation with the use of a mouse model in which RGC degeneration depends as closely as possible on intraocular pressure (IOP) elevation. In this model, injecting the anterior ch

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Smuder, Ashley J., Kisuk Min, Matthew B. Hudson, et al. "Endurance exercise attenuates ventilator-induced diaphragm dysfunction." Journal of Applied Physiology 112, no. 3 (2012): 501–10. http://dx.doi.org/10.1152/japplphysiol.01086.2011.

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Controlled mechanical ventilation (MV) is a life-saving measure for patients in respiratory failure. However, MV renders the diaphragm inactive leading to diaphragm weakness due to both atrophy and contractile dysfunction. It is now established that oxidative stress is a requirement for MV-induced diaphragmatic proteolysis, atrophy, and contractile dysfunction to occur. Given that endurance exercise can elevate diaphragmatic antioxidant capacity and the levels of the cellular stress protein heat shock protein 72 (HSP72), we hypothesized that endurance exercise training before MV would protect

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Hao, Jiayu, Jian Jiang, Qiaoyue Han, Kui Wang, Yuefeng Sun, and Hong Wang. "Neurogenic bladder pathophysiology, assessment and management after lumbar diseases." EFORT Open Reviews 10, no. 3 (2025): 156–65. https://doi.org/10.1530/eor-24-0087.

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Neurogenic bladder (NB) is a group of bladder and/or urethral dysfunctions caused by neurological lesions, commonly seen in patients with lumbar spine diseases, manifesting as urinary storage and voiding dysfunction, significantly affecting patients’ quality of life. Degenerative changes or trauma to the lumbar spine can lead to narrowing of the dural sac, compressing the sacral nerve roots, cauda equina or blood vessels, causing bladder dysfunction and leading to NB. Diagnostic methods for NB include history taking, physical examination and noninvasive and invasive tests, such as urodynamic t

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Antonovich, Ivan I. "Systematic racism in the USA and the problem of polarisation of society." Journal of the Belarusian State University. Sociology, no. 4 (December 28, 2020): 39–49. http://dx.doi.org/10.33581/2521-6821-2020-4-39-49.

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The article analyzes the essence of the radical protests of the African American population of the USA, which exacerbated the crisis of the state social system and have a negative impact on social equilibrium in the countries of the Pan-Atlantic Community. There was made an attempt to trace the negative impact of uncontrollable spontaneous radical protests on global processes. Over the course of two decades of the 21st century, it has become obvious that the USA does not have enough internal resources for the implementation of world-governing tasks, which turned out to be unbearable for the sy

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Yang, Qingling, Xiaoyan Luo, Yujiao Wang, Hui Li, Luping Cong, and Yingpu Sun. "Cerium oxide nanoparticles protect against obesity-induced ovarian dysfunction." Applied Materials Today 22 (March 2021): 100973. http://dx.doi.org/10.1016/j.apmt.2021.100973.

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Bitto, Alessandra, Francesca Polito, Domenica Altavilla, et al. "Melanocortins protect against multiple organ dysfunction syndrome in mice." British Journal of Pharmacology 162, no. 4 (2011): 917–28. http://dx.doi.org/10.1111/j.1476-5381.2010.01098.x.

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Ou-Yang, Ya-nan, Meng-di Yuan, Zheng-mao Yang, Zhuo Min, Yue-xin Jin, and Zhong-min Tian. "Revealing the Pathogenesis of Salt-Sensitive Hypertension in Dahl Salt-Sensitive Rats through Integrated Multi-Omics Analysis." Metabolites 12, no. 11 (2022): 1076. http://dx.doi.org/10.3390/metabo12111076.

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Salt-induced renal metabolism dysfunction is an important mechanism of salt-sensitive hypertension. Given that the gut-liver axis is the first hit of a high-salt diet (HSD), we aimed to identify the extra-renal mechanism from hepatic metabolism and gut microbiota, and attempted to relieve the salt-induced metabolic dysfunctions by curcumin. Untargeted metabolomics analysis was performed to identify the changes in hepatic metabolic pathways, and integrated analysis was employed to reveal the relationship between hepatic metabolic dysfunction and gut microbial composition. HSD induced significan

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Venditti, Paola, and Sergio Di Meo. "The Role of Reactive Oxygen Species in the Life Cycle of the Mitochondrion." International Journal of Molecular Sciences 21, no. 6 (2020): 2173. http://dx.doi.org/10.3390/ijms21062173.

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Currently, it is known that, in living systems, free radicals and other reactive oxygen and nitrogen species play a double role, because they can cause oxidative damage and tissue dysfunction and serve as molecular signals activating stress responses that are beneficial to the organism. It is also known that mitochondria, because of their capacity to produce free radicals, play a major role in tissue oxidative damage and dysfunction and provide protection against excessive tissue dysfunction through several mechanisms, including the stimulation of permeability transition pore opening. This pro

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Chen, Chen, Zhimin Zhao, Jinghong Han, Yue Zhang, and Guohui Nie. "Ptgds downregulation protect vestibular hair cells from aminoglycoside-induced vestibulotoxicity." PLOS ONE 20, no. 4 (2025): e0320634. https://doi.org/10.1371/journal.pone.0320634.

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The clinical use of aminoglycosides often results in injury to vestibular hair cells and subsequent vestibular dysfunction. Thus, clarifying the targets and mechanisms underlying aminoglycoside-mediated damage is of urgent importance. Prostaglandin D2 synthase (Ptgds) is a glycoprotein that plays dual roles in lipid transport regulation and prostaglandin metabolism. However, the role of Ptgds in aminoglycoside-induced vestibular dysfunction remains unclear. This study aimed to explore the function of Ptgds in the utricle and HEI-OC1 cells. Neomycin injury induced high levels of Ptgds expressio

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&NA;. "Protease inhibitors: increased risk of sexual dysfunction." Reactions Weekly &NA;, no. 865 (2001): 5. http://dx.doi.org/10.2165/00128415-200108650-00010.

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Scarff, Katrina L., Kheng S. Ung, Harshal Nandurkar, Peter J. Crack, Catherina H. Bird, and Phillip I. Bird. "Targeted Disruption of SPI3/Serpinb6 Does Not Result in Developmental or Growth Defects, Leukocyte Dysfunction, or Susceptibility to Stroke." Molecular and Cellular Biology 24, no. 9 (2004): 4075–82. http://dx.doi.org/10.1128/mcb.24.9.4075-4082.2004.

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ABSTRACT Protease inhibitor 6 (PI-6/SERPINB6) is a widely expressed nucleocytoplasmic serpin. It inhibits granulocyte cathepsin G and neuronal neuropsin, and it is thought to protect cells from death caused by ectopic release or internalization of protease during stress such as infection or cerebral ischemia. To probe the biological functions of PI-6, we generated mice lacking its ortholog (SPI3/Serpinb6). SPI3-deficient mice developed normally and were fertile, and no abnormal pathology or increased sensitivity to cerebral ischemia was observed. There were no perturbations in leukocyte develo

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Clelland, Claire D., Roger A. Barker, and Colin Watts. "Cell therapy in Huntington disease." Neurosurgical Focus 24, no. 3-4 (2008): E9. http://dx.doi.org/10.3171/foc/2008/24/3-4/e8.

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✓ Huntington disease (HD), caused by polyglutamate expansions in the huntingtin protein, is a progressive neurodegenerative disease resulting in cognitive and motor impairments and death. Neuronal dysfunction and degeneration contribute to progressive physiological, motor, cognitive, and emotional disturbances characteristic of HD. A major impetus for research into the treatment of HD has centered on cell therapy strategies to protect vulnerable neuronal cell populations or to replace dysfunctional or dying cells. The work underlying 3 approaches to HD cell therapy includes the potential for s

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Tezel, Gülgün. "Multifactorial Pathogenic Processes of Retinal Ganglion Cell Degeneration in Glaucoma towards Multi-Target Strategies for Broader Treatment Effects." Cells 10, no. 6 (2021): 1372. http://dx.doi.org/10.3390/cells10061372.

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Glaucoma is a chronic neurodegenerative disease characterized by apoptosis of retinal ganglion cell (RGC) somas, degeneration of axons, and loss of synapses at dendrites and axon terminals. Glaucomatous neurodegeneration encompasses multiple triggers, multiple cell types, and multiple molecular pathways through the etiological paths with biomechanical, vascular, metabolic, oxidative, and inflammatory components. As much as intrinsic responses of RGCs themselves, divergent responses and intricate interactions of the surrounding glia also play decisive roles for the cell fate. Seen from a broad

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Kraidy, Marwan M. "The Lebanese Rise Up Against a Failed System." Current History 118, no. 812 (2019): 361–63. http://dx.doi.org/10.1525/curh.2019.118.812.361.

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Li, Qun, Ji Li, and Jun Ren. "UCF-101 mitigates streptozotocin-induced cardiomyocyte dysfunction: role of AMPK." American Journal of Physiology-Endocrinology and Metabolism 297, no. 4 (2009): E965—E973. http://dx.doi.org/10.1152/ajpendo.00323.2009.

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Diabetic heart disease contributes to the high mortality in diabetics, although effective clinical management is lacking. The protease inhibitor 5-[5-(2-nitrophenyl) furfuryliodine]-1,3-diphenyl-2-thiobarbituric acid (UCF-101) was reported to protect the hearts against ischemic injury. This study examined the role of UCF-101 on streptozotocin (STZ)-induced diabetic heart defect. Vehicle or UCF-101 was administrated to STZ diabetic mice, and cardiomyocyte mechanical properties were analyzed. UCF-101 reduced STZ-induced hyperglycemia and alleviated STZ-induced aberration in cardiomyocyte contrac

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Hirasawa, Yusuke, Toshiro Takai, Toshinobu Nakamura, et al. "Staphylococcus aureus Extracellular Protease Causes Epidermal Barrier Dysfunction." Journal of Investigative Dermatology 130, no. 2 (2010): 614–17. http://dx.doi.org/10.1038/jid.2009.257.

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Zhou, Yuhua, Chunyan Chen, Qingtian Li, Huiqiu Sheng, Xiaokui Guo, and Enqiang Mao. "NORAD modulates miR-30c-5p-LDHA to protect lung endothelial cells damage." Open Medicine 17, no. 1 (2022): 676–88. http://dx.doi.org/10.1515/med-2022-0446.

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Abstract Acute lung injury (ALI) is a devastating human malignancy characterized by excessively uncontrolled inflammation and lung endothelial dysfunction. Non-coding RNAs play essential roles in endothelial protections during the pathological processes of ALI. The precise functions and molecular mechanisms of the lncRNA-NORAD-mediated endothelial protection remain obscure. This study reports NORAD was significantly induced in human pulmonary microvascular endothelial cells (HPMECs) under lipopolysaccharide (LPS) treatment. Silencing NORAD effectively protected HPMECs against the LPS-induced c

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Piollet, Marie, Adrian Sturza, Stéphanie Chadet, et al. "P2Y11 Agonism Prevents Hypoxia/Reoxygenation- and Angiotensin II-Induced Vascular Dysfunction and Intimal Hyperplasia Development." International Journal of Molecular Sciences 22, no. 2 (2021): 855. http://dx.doi.org/10.3390/ijms22020855.

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Vascular dysfunction in cardiovascular diseases includes vasomotor response impairments, endothelial cells (ECs) activation, and smooth muscle cells (SMCs) proliferation and migration to the intima. This results in intimal hyperplasia and vessel failure. We previously reported that activation of the P2Y11 receptor (P2Y11R) in human dendritic cells, cardiofibroblasts and cardiomyocytes was protective against hypoxia/reoxygenation (HR) lesions. In this study, we investigated the role of P2Y11R signaling in vascular dysfunction. P2Y11R activity was modulated using its pharmacological agonist NF54

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Wang, Baoming, Yik Lung Chan, Gerard Li, et al. "Maternal Particulate Matter Exposure Impairs Lung Health and Is Associated with Mitochondrial Damage." Antioxidants 10, no. 7 (2021): 1029. http://dx.doi.org/10.3390/antiox10071029.

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Relatively little is known about the transgenerational effects of chronic maternal exposure to low-level traffic-related air pollution (TRAP) on the offspring lung health, nor are the effects of removing such exposure before pregnancy. Female BALB/c mice were exposed to PM2.5 (PM2.5, 5 µg/day) for 6 weeks before mating and during gestation and lactation; in a subgroup, PM was removed when mating started to model mothers moving to cleaner areas during pregnancy to protect their unborn child (Pre-exposure). Lung pathology was characterised in both dams and offspring. A subcohort of female offspr

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Wang, Haidong, Haohan Chen, Yueying Lin, et al. "Butyrate Glycerides Protect against Intestinal Inflammation and Barrier Dysfunction in Mice." Nutrients 14, no. 19 (2022): 3991. http://dx.doi.org/10.3390/nu14193991.

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This study investigates the attenuating effects of butyrate glycerides (BG) on intestinal inflammatory responses and barrier dysfunction induced by LPS stimulation. An initial dose-response test was carried out to identify the optimal dose of BG for further testing. The mice were given intragastric administration of BG at different doses followed by lipopolysaccharide (LPS) intraperitoneal injection. The small intestinal morphology and cytokine mRNA expression were measured. With 1.5 g/kg BW BG administration, it was possible to alleviate the injury of duodenal morphology, attenuate ileum vill

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Naia, Luana, Teresa Cunha-Oliveira, Joana Rodrigues, et al. "Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease." Journal of Neuroscience 37, no. 10 (2017): 2776–94. http://dx.doi.org/10.1523/jneurosci.2006-14.2016.

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Reddy, P. Hemachandra. "Mitochondrial Dysfunction in Aging and Alzheimer's Disease: Strategies to Protect Neurons." Antioxidants & Redox Signaling 9, no. 10 (2007): 1647–58. http://dx.doi.org/10.1089/ars.2007.1754.

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de Groot, M., P. P. M. Keizer, B. J. de Haan, et al. "Microcapsules and their ability to protect islets against cytokine-mediated dysfunction." Transplantation Proceedings 33, no. 1-2 (2001): 1711–12. http://dx.doi.org/10.1016/s0041-1345(00)02653-1.

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Truran, Seth, Volkmar Weissig, Jillian Madine та ін. "Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide". Journal of Cerebral Blood Flow & Metabolism 36, № 2 (2015): 405–12. http://dx.doi.org/10.1177/0271678x15610134.

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We tested whether nanoliposomes containing phosphatidylcholine, cholesterol and phosphatidic acid (NLPA) prevent β-amyloid 1-42 (Aβ42) fibrillation and Aβ42-induced human arteriole endothelial dysfunction. NLPA abolished Aβ42 fibril formation (thioflavin-T fluorescence/electron microscopy). In ex-vivo human adipose and leptomeningeal arterioles, Aβ42 impaired dilator response to acetylcholine that was reversed by NLPA; this protection was abolished by L-NG-nitroarginine methyl ester. Aβ42 reduced human umbilical vein endothelial cell NO production that was restored by NLPA. Nanoliposomes preve

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Pramadani, Arti, and Sofia Retnowati. "G-CBT for Reducing Depression Symptoms in Individuals from Dysfunctional Family." Gadjah Mada Journal of Professional Psychology (GamaJPP) 10, no. 1 (2024): 64. http://dx.doi.org/10.22146/gamajpp.87363.

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Individuals from dysfunctional family have various risks of mental health deterioration including depression. To solve this family problem actually it is the best to conduct family therapy to the family. But unfortunately not all dysfunctional family are willing to cooperate in family therapy. Therefore individual therapy is considered important to protect individual of dysfunctional family from depression. The aim of this research is to examine the effectivity of Gratitude Cognitive Behavior Therapy in reducing depressive simptoms in individuals from dysfunctional family. Method used in this

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Zhong, Liwen, Mengkai Lu, Huiqi Fang, Chao Li, Hua Qu, and Gang Ding. "Secondary Metabolites from Rehmannia glutinosa Protect Mitochondrial Function in LPS-Injured Endothelial Cells." Pharmaceuticals 18, no. 8 (2025): 1125. https://doi.org/10.3390/ph18081125.

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Background: Rehmannia glutinosa, a traditional Chinese herb, is commonly used to treat vascular-related disorders. Sepsis-associated vascular endothelial dysfunction is closely associated with mitochondrial damage. This study investigated the protective effects of secondary metabolites from R. glutinosa against LPS-induced mitochondrial dysfunction in endothelial cells, providing potential therapeutic insights into sepsis-related vascular complications. Methods: Phytochemical profiling of fresh R. glutinosa roots was conducted, and the structures of new secondary metabolites (1 and 2) were elu

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Sonu, Kumar, Gaurav Prashant, Kumar Sanjeev, Vijaydeep, and Kumar Dhananjay. "Clinical Study of Growth Nutrition and Thyroid Dysfunction in Children Suffering from Beta Thalassemia." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 986–90. https://doi.org/10.5281/zenodo.12738824.

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<strong>Background:</strong> Thalassemia is a hereditary anaemia resulting from defect in haemoglobin production and the most common genetic disorders worldwide. The aim of this case control study was to know the growth patterns and thyroid dysfunction in beta thalassemia major patients. <strong>Materials and Methods:</strong> This study was conducted in the Department of Paediatrics, BMIMS Pawapuri, over a period of two years. The study included 50 homozygous thalassemia major patients, receiving regular blood transfusion and 50 normal children were taken as controls. <str

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Vaquero Martínez, Sergio. "Ruling the streets: the policing of protest and political violence in Madrid during the Second Republic, 1931-1936." Culture & History Digital Journal 13, no. 2 (2025): 518. https://doi.org/10.3989/chdj.2024.518.

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The state has occupied a privileged space in most of the explanations regarding the origins of the political violence that disrupted the course of the Spanish Second Republic. Nevertheless, the generalised notion that the majority of deaths were the outcome of the repression of popular mobilisation contrasts with the practical inexistence of studies devoted to the specific interactions between coercive forces and collective challengers. With the purpose of partially filling this gap, the following article analyses the policing of protest in the province of Madrid from 14 April 1931 to 17 July

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Sonu, Kumar, and Gaurav Prashant. "Clinical Study of Growth, Nutrition and ThyroidDysfunction in Children with Beta Thalassemia." International Journal of Pharmaceutical and Clinical Research 15, no. 5 (2023): 935–41. https://doi.org/10.5281/zenodo.12583500.

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<strong>Background:</strong> Thalassemia is a hereditary anaemia resulting from defect in haemoglobin production and the most common genetic disorders worldwide. The aim of this case control study was to know the growth patterns and thyroid dysfunction in beta thalassemia major patients. <strong>Materials and Methods:</strong> This study was conducted in the Department of Paediatrics, BMIMS Pawapuri, over a period of two years. The study included 50 homozygous thalassemia major patients, receiving regular blood transfusion and 50 normal children were taken as controls. <str

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