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Journal articles on the topic 'Dyslipidaemic'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Batista, Kamila Sabino, Adriano Francisco Alves, Marcos dos Santos Lima, et al. "Beneficial effects of consumption of acerola, cashew or guava processing by-products on intestinal health and lipid metabolism in dyslipidaemic female Wistar rats." British Journal of Nutrition 119, no. 1 (2018): 30–41. http://dx.doi.org/10.1017/s0007114517003282.

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AbstractThis study assessed the effects of diet supplementation with industrial processing by-products of acerola (Malpighia emarginataD.C.), cashew (Anacardium occidentaleL.) and guava (Psidium guajavaL.) fruit on the intestinal health and lipid metabolism of female Wistar rats with diet-induced dyslipidaemia. Female rats were randomly divided into five groups: healthy control, dyslipidaemic control and dyslipidaemic experimental receiving acerola, cashew or guava processing by-products. Fruit processing by-products were administered (400 mg/kg body weight) via orogastric administration for 2

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Tasnim, Tasmia, Kazi Muhammad Rezaul Karim, and Chaity Bhatta. "Association of diet quality and nutrient intake with odds of dyslipidaemia in patients with cardiovascular diseases: a hospital based cross-sectional study in Bangladesh." BMJ Open 14, no. 12 (2024): e091025. https://doi.org/10.1136/bmjopen-2024-091025.

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ObjectiveThe aim of this study is to evaluate diet quality and other associated factors with dyslipidaemia in cardiovascular disease (CVD) patients in Bangladesh.DesignThe study employed a cross-sectional design.SettingData from medical records, dietary intake and socioeconomic factors were collected from January to October 2022 at the National Institute of Cardiovascular Disease, Dhaka, and Noakhali Sadar Hospital.ParticipantsA total of 570 CVD patients, aged 25–80 years, with a confirmed diagnosis within the past 3 months, were included in the study.Main outcome measuresThe primary outcomes

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Jain, Shilpa, and J. L. Marko. "Cost variation analysis of oral anti-dyslipidaemic drugs available in Indian pharmaceutical market." International Journal of Basic & Clinical Pharmacology 9, no. 5 (2020): 753. http://dx.doi.org/10.18203/2319-2003.ijbcp20201752.

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Background: Dyslipidaemia is one of major risk factor contributing to cardiovascular disease, which further causes mortality and morbidity, so requires a long course of treatment. Physicians should be aware of the cost of drugs.Methods: Cost of the oral anti-dyslipidaemic drug, either as single drug or in combination manufactured by different pharmaceutical companies in the same strength and dosage form was obtained from current index of medical specialities (CIMS) April-July 2019. The difference in the maximum and minimum price of the same drug manufactured by different pharmaceutical compani

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de Araújo, Emmanuel Veríssimo, Keyth Sulamitta de Lima Guimarães, Marciane Magnani, et al. "Maternal dyslipidemia during pregnancy and lactation increases blood pressure and disrupts cardiorespiratory and glucose hemostasis in female rat offspring." Applied Physiology, Nutrition, and Metabolism 44, no. 9 (2019): 925–36. http://dx.doi.org/10.1139/apnm-2018-0756.

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Hypertension and metabolic disorders evidenced in adults who have been exposed to nutritional insults during early life may be sex-dependent. We evaluated if blood pressure (BP), cardiorespiratory control, and metabolic parameters are affected in female offspring (FO) from dams fed a dyslipidaemic diet during pregnancy and lactation. FO was obtained from dams who received control (CTL) or dyslipidaemic diets during pregnancy and lactation. The effects of a maternal dyslipidaemic diet on BP, cardiorespiratory control, and biochemical parameters were assessed at 30 and 90 days of age. The experi

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HALDER, SUJASH, RAHUL DAS, and SWAGATA KOLEY. "<b>Estimation of lipid profile among prediabetic and diabetic patients attending Central laboratory, in an apex medical college in eastern India: An observational study</b>." National Journal of Physiology, Pharmacy and Pharmacology 14, no. 12 (2024): 2530. https://doi.org/10.5455/njppp.2024.v14.i12.6.

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<b>Background:</b> Dyslipidaemia is a metabolic disorder of lipoproteins characterized by abnormal lipid profile. India has a huge burden of diabetes mellitus making India the second highest diabetic capital in the world. Dyslipidemia plays a crucial role in different complications in both prediabetes and diabetes patients. <b>Aim:</b> This study was conducted to assess the lipid profile among both the diabetic patients and prediabetic individuals, in a tertiary care hospital in Eastern India. <b>Methods:</b> This observational cross-sectional study was cond

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Ceska, Richard. "Clinical implications of the metabolic syndrome." Diabetes and Vascular Disease Research 4, no. 3_suppl (2007): S2—S4. http://dx.doi.org/10.3132/dvdr.2007.049.

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The prevalence of the metabolic syndrome among developed countries is rising, and this is largely driven by increasing obesity rates. Central obesity plays a key role in the pathogenesis of the metabolic syndrome: it promotes inflammation, hypertension and dyslipidaemia, and leads to the development of type 2 diabetes mellitus and atherosclerosis. Clinical management should be focused on multifactorial intervention to address all the associated cardiovascular risk factors. The atherogenic mixed dyslipidaemic profile associated with the metabolic syndrome is an important target for intervention

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Harangi, Mariann, Noémi Zsíros, and Nóra Tóth. "A lipidanyagcsere zavarai endokrin betegségekben." Lege Artis Medicinae 33, no. 10-11 (2023): 511–21. http://dx.doi.org/10.33616/lam.33.0511.

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A dyslipidaemia kulcsszerepet játszik számos cardiovascularis megbetegedés patomechanizmusában. Számos betegnél nem a lipoprotein-anyagcsere primer zavaráról van szó, hanem a dyslipidaemiát valamely „nem lipid” ok magyarázza. Ezen szekunder dyslipidaemiák meglepően gyakoriak, a hátterükben álló eltérések gyakran nem kerülnek felismerésre, hacsak nem keressük őket aktívan. Az endokrin megbetegedések gyakran társulnak dyslipidaemiával, ide sorolható a hypothyreosis, a diabetes mellitus, a Cushing-szindróma, az acromegalia, a hypogonadismus, a növekedésihormon-deficientia, a hyperprolactinaemia é

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Meka, Ijeoma A., Obumneme B. Anyim, Joseph T. Enebe, Kingsley N. Ukwaja, and Martin C. Ugonabo. "Association of miRNA122 & ADAM17 with lipids among hypertensives in Nigeria." Open Medicine 13, no. 1 (2018): 350–58. http://dx.doi.org/10.1515/med-2018-0053.

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AbstractBackgroundDyslipidaemia and hypertension are established major risk factors for cardiovascular diseases. The suggested roles of miRNA-122 and ADAM17 in lipid metabolism can therefore be applied in the management of metabolic disorders. The authors’ aim was to determine the association between miRNA-122 and ADAM17, as well as the association between miRNA-122 and lipid fractions, in the study participants.MethodA comparative cross-sectional study was conducted among 200 hypertensive patients and 100 non-hypertensive adult controls between May, 2015, and June, 2016, in Nigeria. Lipids we

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Chapman, M. John. "Metabolic syndrome and type 2 diabetes: lipid and physiological consequences." Diabetes and Vascular Disease Research 4, no. 3_suppl (2007): S5—S8. http://dx.doi.org/10.3132/dvdr.2007.050.

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The metabolic syndrome and type 2 diabetes are insulin-resistant states which are commonly associated with an atherogenic dyslipidaemia involving mild to moderately elevated triglycerides, a preponderance of small, dense low-density lipoprotein (LDL) particles and low levels of high-density lipoprotein cholesterol (HDL-C). In addition, there is a spectrum of qualitative changes in the lipoprotein profile, particularly in the functional capacity of HDL to facilitate cellular cholesterol efflux and to protect LDL against oxidative modification. Together, these quantitative and qualitative anomal

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Silva, J. M., I. Souza, R. Silva, F. Teixeira, and P. S. Silva. "Fish oils in Portuguese dyslipidaemic patients." Atherosclerosis 115 (June 1995): S45. http://dx.doi.org/10.1016/0021-9150(95)96419-s.

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Kakar, Sheena, Douglas Drak, Tahiya Amin, Jason Cheung, Catherine O'Connor, and David Gracey. "Screening and management of risk factors for cardiovascular disease in HIV-positive patients attending an Australian urban sexual health clinic." Sexual Health 14, no. 2 (2017): 198. http://dx.doi.org/10.1071/sh16106.

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Background Few data exist regarding cardiovascular risk among HIV-infected patients attending sexual health clinics (SHC) in Australia. Methods: The medical records of 188 patients attending an inner-city SHC between August 2013 and July 2014 were retrospectively reviewed for cardiovascular risk factors and associated screening and management practices. Results: Cardiovascular risk factors were common among attendees of the SHC, including smoking (38%), hypertension (14%) and dyslipidaemia (11%). Of the 188 patients, 23% reported using potentially cardiotoxic recreational drugs, 25% of dyslipi

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Lee, Chien-Ying, Kuang-Hua Huang, Chun-Che Lin, Tung-Han Tsai, and Hung-Che Shih. "A Neutral Risk on the Development of New-Onset Diabetes Mellitus (NODM) in Taiwanese Patients with Dyslipidaemia Treated with Fibrates." Scientific World Journal 2012 (2012): 1–5. http://dx.doi.org/10.1100/2012/392734.

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There are no data on the incidence of new-onset diabetes mellitus (NODM ) in nondiabetic dyslipidaemia patients treated with fibrates. The aim of our study was to clarify these issues, to investigate the relationship between NODM and fibrate and whether the fibrates lead to increased risk for developing NODM. A retrospective cohort study was conducted by analyzing the Longitudinal Health Insurance Database (LHID 2005) of the National Health Insurance Research Database (NHIRD) from 2005 to 2010 to investigate all fibrate prescriptions for patients with dyslipidaemia. We estimated the hazard rat

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Ghosh, Sutirtha, Archana Gaur, Trina Sengupta, Mithu Banerjee, and Prasunpriya Nayak. "Effect of aluminium on lipid profile and atherogenic index in prepubertal and young adult female rats: A pilot study." Indian Journal of Physiology and Pharmacology 67 (July 1, 2023): 92–99. http://dx.doi.org/10.25259/ijpp_338_2022.

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Objectives: Exposure of aluminium (Al) to mankind is inescapable, and its dyslipidaemic impact is a possible contributing factor to health hazards like cardiovascular diseases. The health effects due to the metalloestrogenic property of the metal need imperative consideration. The current experimental work was undertaken to explore Al-induced dyslipidaemia due to its metalloestrogenic property. Materials and Methods: To fulfil this objective, prepubertal (PP) and young adult (YA) female Wistar rats were intraperitoneally administered to two doses of Al [5 and 10 mg/Kg body weight (BW)] once da

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Razavian, S. M., M. Del-Pino, C. Duche, A. Simon, and J. Levenson. "Increased erythrocyte aggregation in dyslipidaemic normotensive men." Journal of Hypertension 10, no. 10 (1992): 1301. http://dx.doi.org/10.1097/00004872-199210000-00060.

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15

Holman, R. "The UKPDS: implications for the dyslipidaemic patient." Acta Diabetologica 38, no. 5 (2001): S9—S14. http://dx.doi.org/10.1007/s005920170003.

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Oliva, María E., Dante Selenscig, María E. D'Alessandro, Adriana Chicco, and Yolanda B. Lombardo. "Soya protein ameliorates the metabolic abnormalities of dysfunctional adipose tissue of dyslipidaemic rats fed a sucrose-rich diet." British Journal of Nutrition 105, no. 8 (2010): 1188–98. http://dx.doi.org/10.1017/s0007114510004915.

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The present study investigates whether the replacement of dietary casein by soya protein isolate could be able to improve and/or even revert the morphological and metabolic abnormalities underlying the adipose tissue dysfunction of dyslipidaemic rats chronically fed (8 months) a sucrose-rich (62·5 %) diet (SRD). For this purpose, Wistar rats were fed a SRD for 4 months. From months 4 to 8, half the animals continued with the SRD and the other half were fed a SRD in which the source of protein, casein, was substituted by soya. The control group received a diet in which the source of carbohydrat

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Williams, Roger R., Paul N. Hopkins, Steven C. Hunt, et al. "Familial Dyslipidaemic Hypertension and Other Multiple Metabolic Syndromes." Annals of Medicine 24, no. 6 (1992): 469–75. http://dx.doi.org/10.3109/07853899209166998.

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18

Ghosh, A. "Anthropometric, central obesity, metabolic and blood pressure variables in dyslipidaemic and non-dyslipidaemic adult Bengalee Hindu men of Calcutta, India." Nutrition, Metabolism and Cardiovascular Diseases 14, no. 3 (2004): 170–72. http://dx.doi.org/10.1016/s0939-4753(04)80038-3.

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19

J. Dung, Nehemiah, Mark M. Tettey, Martin Tamatey, et al. "Angiographic severity of coronary artery disease and the influence of major cardiovascular risk factors." Ghana Medical Journal 57, no. 4 (2023): 262–69. http://dx.doi.org/10.4314/gmj.v57i4.2.

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Objective: To determine the angiographic severity of coronary artery disease (CAD) and assess the influence of major cardiovascular risk factors (CVRF).Study design: a cross-sectional, hospital-based study.Setting: the catheterisation laboratory of the National Cardiothoracic Centre, Accra, Ghana.Participants: for 12 months, consecutive patients admitted for coronary angiography were assessed for the presence of CVRFs. Those with significant CAD after angiography were recruited into the study.Intervention: The patient’s angiograms were analysed, and the CAD severity was obtained using the SYNT

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Lamprea-Montealegre, Julio A., Robyn L. McClelland, Morgan Grams, Pamela Ouyang, Moyses Szklo, and Ian H. de Boer. "Coronary heart disease risk associated with the dyslipidaemia of chronic kidney disease." Heart 104, no. 17 (2018): 1455–60. http://dx.doi.org/10.1136/heartjnl-2017-312794.

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ObjectiveThis study sought to characterise the main dyslipidaemic phenotypes present in chronic kidney disease (CKD) and their association with coronary heart disease (CHD) risk.MethodsAnalyses included 6612 individuals in the multiethnic study of atherosclerosis free of CHD at baseline. CKD was defined as an estimated glomerular filtration rate (eGFR) of 15 to <60 mL/min/1.73 m2 (stages 3–4). Principal component analyses were used to characterise the main dyslipidaemic phenotypes of CKD accounting for the correlation among different lipoproteins and lipoprotein particles. CHD was defined a

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Hudgins, Lisa C., Vidhya Annavajjhala, Arzu Kovanlikaya, et al. "Non-invasive assessment of endothelial function in children with obesity and lipid disorders." Cardiology in the Young 26, no. 3 (2015): 532–38. http://dx.doi.org/10.1017/s1047951115000657.

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AbstractBackgroundDigital tonometry is designed to non-invasively screen for endothelial dysfunction by the detection of impaired flow-induced reactive hyperaemia in the fingertip. We determined whether digital reactive hyperaemia correlated with risk factors for atherosclerosis in two groups of children at increased risk for endothelial dysfunction.MethodsA total of 15 obese children and 23 non-obese, dyslipidaemic children, 8–21 years of age, were enrolled, and their medical histories, anthropometric measurements, carotid wall thickness by means of ultrasonography, and fasting blood samples

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Bottazzo, S., G. Pagan, and P. Zanchi. "Effects of simvastatin in dyslipidaemic patients with liver steatosis." Atherosclerosis Supplements 2, no. 2 (2001): 96–97. http://dx.doi.org/10.1016/s1567-5688(01)80251-8.

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Nasrin, Nadia. "Newly-developed De Cordovaâ€™s Formula for Calculation of LDL Cholesterol in Bangladeshi Population." Borneo Journal of Medical Sciences (BJMS) 11, no. 3 (2017): 25–34. http://dx.doi.org/10.51200/bjms.v11i3.977.

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Raised serum LDL cholesterol is an important modifiable risk factor for the development of atherosclerosis and cardiovascular disease. So the management ofÂ dyslipidaemia is mostlyÂ based on the concentration of LDL cholesterol. Friedewaldâ€™s formula is commonly used method to estimate LDL cholesterol in most clinical laboratories. However, this formula cannot reflect the actual figure of LDL cholesterol. In 2013, de Cordova developed a new simple formula to calculate LDL cholesterol without using serum TG which is said to be more accurate than Friedewaldâ€™s formula. The present study was de

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Paschos, George K., Loukianos S. Rallidis, Georgios K. Liakos та ін. "Background diet influences the anti-inflammatory effect of α-linolenic acid in dyslipidaemic subjects". British Journal of Nutrition 92, № 4 (2004): 649–55. http://dx.doi.org/10.1079/bjn20041230.

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Long-chain n-3 PUFA from fish oils are known to have anti-inflammatory effects. We evaluated the effect of α-linolenic acid (ALA), precursor of n-3 fatty acids, on serum inflammatory markers and soluble cellular adhesion molecules (sCAM) of dyslipidaemic males, relative to their background diet. Participants were assigned to two groups, based upon food intake patterns: (a) twenty-one dyslipidaemic subjects who habitually ate a Mediterranean–Cretan-type diet; (b) nineteen dyslipidaemic subjects who normally ate a Westernised Greek diet. All were supplemented with 8·1 g ALA/d for 12 weeks. We de

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&NA;. "Statins may reduce CHD risk in non-dyslipidaemic hypertensive patients." Inpharma Weekly &NA;, no. 1382 (2003): 15. http://dx.doi.org/10.2165/00128413-200313820-00031.

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Lupattelli, Graziana, Matteo Pirro, Massimo R. Mannarino, et al. "Visceral fat positively correlates with cholesterol synthesis in dyslipidaemic patients." European Journal of Clinical Investigation 42, no. 2 (2011): 164–70. http://dx.doi.org/10.1111/j.1365-2362.2011.02572.x.

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Tsukiyama, Hisaichiro, and Keiko Otsuka. "Effects of pravastatin in dyslipidaemic patients with and without hypertension." Journal of Hypertension 11, no. 5 (1993): S346???S347. http://dx.doi.org/10.1097/00004872-199312050-00152.

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Anagnostopoulou, K. K., G. D. Kolovou, K. D. Salpea, et al. "Th-P15:60 Plasma triglycerides and lipoproteins in dyslipidaemic patients." Atherosclerosis Supplements 7, no. 3 (2006): 505–6. http://dx.doi.org/10.1016/s1567-5688(06)82020-9.

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Giménez-Campillo, Claudia, Marta Pastor-Belda, Natalia Arroyo-Manzanares, et al. "Dilute-and-Shoot-Liquid Chromatography-Quadrupole Time of Flight-Mass Spectrometry for Pteridine Profiling in Human Urine and Its Association with Different Pathologies." Chemosensors 11, no. 6 (2023): 324. http://dx.doi.org/10.3390/chemosensors11060324.

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Pteridines are a group of compounds synthesised by many living organisms that are involved in the metabolism of many cofactors and vitamins. Their concentration in biological fluids may be altered by various pathologies such as cancer or inflammatory bowel disease, urine being the main route of excretion. In this study, three lumazines and ten pterins were analysed in their native oxidation state using high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Their high concentration in urine samples and their good ionisation behaviour allow the use of the

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Rahman, Md Rezwanur, M. Iqbal Arslan, Md Mozammel Hoque, Forhadul Hoque Mollah, and Shahana Shermin. "Serum Lipids and Diabetic Retinopathy in Newly Diagnosed Type 2 Diabetic Subjects." Journal of Enam Medical College 1, no. 2 (2012): 63–66. http://dx.doi.org/10.3329/jemc.v1i2.11464.

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Background: Diabetic retinopathy is the commonest and usually the first observable vascular complication of diabetes mellitus. Along with hyperglycaemia, dyslipidaemia is a contributing factor for the occurrence of diabetic retinopathy. It is postulated that dyslipidaemia results in formation of hard exudate by increasing blood viscosity and altering the fibrinolytic system. A case control study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka during the period of January 2006 to December 2007 to evaluate the serum lipid profile in newly dia

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Öngen, Belkız, Sema Kalkan Uçar, Ertürk Levent, et al. "Lipoprotein-associated phospholipase A2: a new marker to determine cardiovascular risk in hypercholesterolemic dyslipidaemic children." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 54, no. 5 (2016): 539–47. http://dx.doi.org/10.1177/0004563216671338.

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Background Inflammation and hypercholesterolaemia contribute to atherosclerotic changes which can start in childhood. Children with hyperlipidaemias are at high risk for early coronary atherosclerosis. This study evaluates the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2), carotid intima-media thickness (CIMT) and flow-mediated dilatation in hypercholesterolaemic dyslipidaemic children. Methods We performed a case–control study consisting of 43 cases, aged 2 to 17 years, and 24 age-matched controls. Fasting blood samples were obtained from both groups for the measureme

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G., Swapna, Udaya Bindu K., and Jeevitha Naik B. "Evaluation of the Effect of Atorvastatin on Insulin Sensitivity at Tertiary Care Hospital, Telangana State." International Journal of Toxicological and Pharmacological Research 13, no. 3 (2023): 375–82. https://doi.org/10.5281/zenodo.11222117.

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<strong>Aim of the Study: </strong>To evaluate the effects of Atorvastatin on insulin sensitivity. <strong>Material & Methods: </strong>The patients were randomized into two groups, of 34 patients each, by a random selection process. The experimental group consisting of 34 dyslipidaemic and hypertensive patients receiving atorvastatin 10mg/day and atenolol 50 mg/day at the Hypertension OPD at Government Tertiary Care Hospital, Telangana State are chosen as volunteers and are compared with another group of 34 hypertensive patients receiving atenolol 50 mg/day only. <stro

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Adegoke, SA, JAO Okeniyi, and AA Akintunde. "Electrocardiographic abnormalities and dyslipidaemic syndrome in children with sickle cell anaemia." Cardiovascular Journal Of Africa 27, no. 1 (2016): 16–20. http://dx.doi.org/10.5830/cvja-2015-059.

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Anderson, F., S. R. Thomson, D. L. Clarke, and I. Buccimazza. "Dyslipidaemic Pancreatitis Clinical Assessment and Analysis of Disease Severity and Outcomes." Pancreatology 9, no. 3 (2009): 252–57. http://dx.doi.org/10.1159/000212091.

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Cappelli, Carlo, Maurizio Castellano, Ilenia Pirola, et al. "Reduced thyroid volume and nodularity in dyslipidaemic patients on statin treatment." Clinical Endocrinology 68, no. 1 (2008): 16–21. http://dx.doi.org/10.1111/j.1365-2265.2007.02982.x.

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Haqiqi, A., J. Cegla, and B. Jones. "Statin treatment reduces plasma FGF19 in healthy volunteers and dyslipidaemic patients." Atherosclerosis 315 (December 2020): e153-e154. http://dx.doi.org/10.1016/j.atherosclerosis.2020.10.475.

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Playford, D. A., and G. F. Watts. "Fenofibrate improves endothelial function in dyslipidaemic Non-Insulin Dependent Diabetes (NIDDM)." Atherosclerosis 151, no. 1 (2000): 209. http://dx.doi.org/10.1016/s0021-9150(00)80950-8.

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Paschos, G. K., F. Magkos, D. B. Panagiotakos, V. Votteas, and A. Zampelas. "Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients." European Journal of Clinical Nutrition 61, no. 10 (2007): 1201–6. http://dx.doi.org/10.1038/sj.ejcn.1602631.

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Yokomichi, Hiroshi, Hokuto Noda, Akiko Nagai, et al. "Cholesterol levels of Japanese dyslipidaemic patients with various comorbidities: BioBank Japan." Journal of Epidemiology 27, no. 3 (2017): S77—S83. http://dx.doi.org/10.1016/j.je.2016.12.014.

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Jacotot, Bernard, John Betteridge, Gerd Assmann, et al. "Round table discussion: practical issues in the management of dyslipidaemic patients." Atherosclerosis 124 (July 1996): S89—S97. http://dx.doi.org/10.1016/0021-9150(96)05862-5.

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Demetz, Egon, Piotr Tymoszuk, Richard Hilbe, et al. "The haemochromatosis gene Hfe and Kupffer cells control LDL cholesterol homeostasis and impact on atherosclerosis development." European Heart Journal 41, no. 40 (2020): 3949–59. http://dx.doi.org/10.1093/eurheartj/ehaa140.

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Abstract Aims Imbalances of iron metabolism have been linked to the development of atherosclerosis. However, subjects with hereditary haemochromatosis have a lower prevalence of cardiovascular disease. The aim of our study was to understand the underlying mechanisms by combining data from genome-wide association study analyses in humans, CRISPR/Cas9 genome editing, and loss-of-function studies in mice. Methods and results Our analysis of the Global Lipids Genetics Consortium (GLGC) dataset revealed that single nucleotide polymorphisms (SNPs) in the haemochromatosis gene HFE associate with redu

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Ibrahim, Fatima, Lamidi Usman, Jubril Akolade, Oluwafemi Idowu, Azeemat Abdulazeez, and Aliyu Amuzat. "Antidiabetic Potentials of Citrus aurantifolia Leaf Essential Oil." Drug Research 69, no. 04 (2018): 201–6. http://dx.doi.org/10.1055/a-0662-5607.

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Abstract Citrus aurantifolia leaf essential oil was extracted via hydrodistillation, chemical composition of the oil was analyzed using gas chromatography-mass spectrometry and its antidiabetic potentials was assessed in alloxan-induced hyperglycaemic rats using metformin as the reference drug for comparison. Chemical analysis showed that D-limonene (57.84%) was the major constituent of the oil. Other notable compounds identified were neral (7.81%), linalool (4.75%), sulcatone (3.48%) and isogeraniol (3.48%). Intraperitoneal administration of C. aurantifolia oil (100 mg/Kg b.wt.) to hyperglyca

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Ojoye N. Briggs and Kemzi N. Elechi-Amadi. "Multisystemic effects of the herbal formulation cholesterol defence in high-fat diet-induced dyslipidaemic rats." International Journal of Biological and Pharmaceutical Sciences Archive 8, no. 2 (2024): 146–53. https://doi.org/10.53771/ijbpsa.2024.8.2.0091.

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Aim: This study evaluated the multisystemic effects of the herbal formulation cholesterol defence, in high-fat diet-induced dyslipidaemic rats. Methodology: A total of 35 male albino rats weighing between 160 to 180g were used for the study. The rats were weighed and grouped into 5 groups of 7 rats each. They were fed high fat diet for 6 weeks. 2 weeks before commencement of treatments and then 4 weeks alongside the treatments. Group 1 was negative control and group 2 positive control. Group 3 was administered metformin, group 4 administered CholesDefence, and group 5 administered a combinatio

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Guimarães, Keyth Sulamitta L., Emmanuel Veríssimo de Araújo, Jailane Souza Aquino, et al. "Effect of maternal dyslipidaemia on the cardiorespiratory physiology and biochemical parameters in male rat offspring." British Journal of Nutrition 118, no. 11 (2017): 930–41. http://dx.doi.org/10.1017/s0007114517003014.

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AbstractThe present study evaluated the effects of maternal dyslipidaemia on blood pressure (BP), cardiorespiratory physiology and biochemical parameters in male offspring. Wistar rat dams were fed either a control (CTL) or a dyslipidaemic (DLP) diet during pregnancy and lactation. After weaning, both CTL and DLP offspring received standard diet. On the 30th and 90th day of life, blood samples were collected for metabolic analyses. Direct measurements of BP, respiratory frequency (RF), tidal volume (VT) and ventilation (VE) under baseline condition, as well as during hypercapnia (7 % CO2) and

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Chen, Jian-Hua, Maria Segni, Felicity Payne, et al. "Truncation of POC1A associated with short stature and extreme insulin resistance." Journal of Molecular Endocrinology 55, no. 2 (2015): 147–58. http://dx.doi.org/10.1530/jme-15-0090.

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We describe a female proband with primordial dwarfism, skeletal dysplasia, facial dysmorphism, extreme dyslipidaemic insulin resistance and fatty liver associated with a novel homozygous frameshift mutation in POC1A, predicted to affect two of the three protein products of the gene. POC1A encodes a protein associated with centrioles throughout the cell cycle and implicated in both mitotic spindle and primary ciliary function. Three homozygous mutations affecting all isoforms of POC1A have recently been implicated in a similar syndrome of primordial dwarfism, although no detailed metabolic phen

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Azadbakht, Leila, Parvin Mirmiran, Mehdi Hedayati, Ahmad Esmaillzadeh, Nilufar Shiva, and Fereidoun Azizi. "Particle size of LDL is affected by the National Cholesterol Education Program (NCEP) step II diet in dyslipidaemic adolescents." British Journal of Nutrition 98, no. 1 (2007): 134–39. http://dx.doi.org/10.1017/s0007114507657857.

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The objective was to determine the effects of the National Cholesterol Education Program (NCEP) step II diet on LDL and HDL particle size in dyslipidaemic adolescents. Forty-four dyslipidaemic adolescents, aged 10–18 years, participated in this case-control study. The control diet was a diet similar to what most Tehranian adolescents eat. NCEP step II diet was a diet with 30 % of energy as total fat, less than 7 % saturated fat, less than 200 mg cholesterol/d, less than 15 % of energy as MUFA and less than 10 % as PUFA. Lipoprotein particle size was the major outcome variable, which was measur

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Drouin, A., M.-È. Gendron, E. Thorin, M.-A. Gillis, F. Mahlberg-Gaudin, and J.-C. Tardif. "Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice." British Journal of Pharmacology 154, no. 4 (2008): 749–57. http://dx.doi.org/10.1038/bjp.2008.116.

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Myers, J., M. Rayment, S. Sonecha, G. Moyle, and M. Boffito. "Room for manoeuvre when prescribing statins to dyslipidaemic patients on antiretroviral therapy." HIV Medicine 13, no. 3 (2012): 190–92. http://dx.doi.org/10.1111/j.1468-1293.2011.00957.x.

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&NA;. "Nicotinic acid should be used with caution in dyslipidaemic patients with NIDDM." Inpharma Weekly &NA;, no. 750 (1990): 14. http://dx.doi.org/10.2165/00128413-199007500-00036.

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Ghayour-Mobarhan, Majid, David J. Lamb, Andrew Taylor, et al. "Effect of statin therapy on serum trace element status in dyslipidaemic subjects." Journal of Trace Elements in Medicine and Biology 19, no. 1 (2005): 61–67. http://dx.doi.org/10.1016/j.jtemb.2005.06.003.

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