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Journal articles on the topic 'E-cig'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Pearson, Jennifer L., Domonique M. Reed, and Andrea C. Villanti. "Vapes, E-cigs, and Mods: What Do Young Adults Call E-cigarettes?" Nicotine & Tobacco Research 22, no. 5 (2018): 848–52. http://dx.doi.org/10.1093/ntr/nty223.

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Abstract Introduction A diverse class of products, “e-cigarettes” present surveillance and regulatory challenges because of nonstandard terminology used to describe subtypes, especially among young adults, where occasional e-cig use is most prevalent. Methods Young adults (n = 3364) in wave 9 (Spring 2016) of the Truth Initiative Young Adult Cohort were randomized to see two of five photos of common e-cig products (three varieties of first-generation e-cigs and one variety each of second- and third-generation e-cigs). Qualitative responses were coded into nine classifications: “e-cigarette, e-

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Li, Liqiao, Yan Lin, Tian Xia, and Yifang Zhu. "Effects of Electronic Cigarettes on Indoor Air Quality and Health." Annual Review of Public Health 41, no. 1 (2020): 363–80. http://dx.doi.org/10.1146/annurev-publhealth-040119-094043.

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With the rapid increase in electronic cigarette (e-cig) users worldwide, secondhand exposure to e-cig aerosols has become a serious public health concern. We summarize the evidence on the effects of e-cigs on indoor air quality, chemical compositions of mainstream and secondhand e-cig aerosols, and associated respiratory and cardiovascular effects. The use of e-cigs in indoor environments leads to high levels of fine and ultrafine particles similar to tobacco cigarettes (t-cigs). Concentrations of chemical compounds in e-cig aerosols are generally lower than those in t-cig smoke, but a substan

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Yingst, Jessica, Jonathan Foulds, Susan Veldheer, et al. "Measurement of Electronic Cigarette Frequency of Use Among Smokers Participating in a Randomized Controlled Trial." Nicotine & Tobacco Research 22, no. 5 (2018): 699–704. http://dx.doi.org/10.1093/ntr/nty233.

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Abstract Background The United States Food and Drug Administration has prioritized understanding the dependence potential of electronic cigarettes (e-cigs). Dependence is often estimated in part by examining frequency of use; however measures of e-cig use are not well developed because of varying product types. This study used an e-cig automatic puff counter to evaluate the value of self-reported e-cig use measures in predicting actual use (puffs). Methods Data were collected from a two-site randomized placebo-controlled trial evaluating the effects of e-cigs on toxicant exposure in smokers at

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Buczek, Erin J., Kathleen F. Harrington, Peter S. Hendricks, and Cecelia E. Schmalbach. "Electronic Cigarette Awareness, Use, and Perceptions among Cancer Patients." OTO Open 2, no. 2 (2018): 2473974X1877454. http://dx.doi.org/10.1177/2473974x18774543.

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Objective Electronic cigarettes (e-cigs) are an emerging trend, yet little is known about their use in the cancer population. The objectives of this study were (1) to describe characteristics of e-cig use among cancer patients, (2) to define e-cig advertising exposure, and (3) to characterize perceptions of traditional cigarettes versus e-cigs. Study Design Cross-sectional study. Setting Comprehensive cancer center. Subjects and Methods Inpatient, current smokers with a cancer diagnosis. E-cig exposure and use were defined using descriptive statistics. Wilcoxon rank test was used to compare pe

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Chang, YS, SM Park, YC Rah, et al. "In vivo assessment of the toxicity of electronic cigarettes to zebrafish (Danio rerio) embryos, following gestational exposure, in terms of mortality, developmental toxicity, and hair cell damage: Toxicity of E-cigs to zebrafish embryos." Human & Experimental Toxicology 40, no. 1 (2020): 148–57. http://dx.doi.org/10.1177/0960327120947785.

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With the ban of conventional cigarettes from public spaces, electronic cigarette (E-cig) liquids have emerged as a nicotine replacement treatment for smoking cessation. However, consumers possess little knowledge of the ingredients and health effects of E-cig liquids following exposure. This study evaluated hair cell damage and developmental toxicities following gestational exposure to E-cig liquids. Zebrafish embryos were exposed to E-cig liquids at different concentrations (0.1%, 0.2%, and 0.4%). Embryonic developmental toxicity and hair cell damage was evaluated at 6 and 7 d, respectively,

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Dingle, M., and A. Travers. "E-cig explosions." British Dental Journal 228, no. 3 (2020): 137–38. http://dx.doi.org/10.1038/s41415-020-1267-6.

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Rowell, Temperance R., and Robert Tarran. "Will chronic e-cigarette use cause lung disease?" American Journal of Physiology-Lung Cellular and Molecular Physiology 309, no. 12 (2015): L1398—L1409. http://dx.doi.org/10.1152/ajplung.00272.2015.

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Chronic tobacco smoking is a major cause of preventable morbidity and mortality worldwide. In the lung, tobacco smoking increases the risk of lung cancer, and also causes chronic obstructive pulmonary disease (COPD), which encompasses both emphysema and chronic bronchitis. E-cigarettes (E-Cigs), or electronic nicotine delivery systems, were developed over a decade ago and are designed to deliver nicotine without combusting tobacco. Although tobacco smoking has declined since the 1950s, E-Cig usage has increased, attracting both former tobacco smokers and never smokers. E-Cig liquids (e-liquids

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Jin, Lexiao, Jordan Lynch, Andre Richardson, et al. "Electronic cigarette solvents, pulmonary irritation, and endothelial dysfunction: role of acetaldehyde and formaldehyde." American Journal of Physiology-Heart and Circulatory Physiology 320, no. 4 (2021): H1510—H1525. http://dx.doi.org/10.1152/ajpheart.00878.2020.

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Use of electronic cigarettes (E-cig) induces endothelial dysfunction (ED) in healthy humans, yet the specific constituents in E-cig aerosols that contribute to ED are unknown. Our study implicates formaldehyde that is formed in heating of E-cig solvents (propylene glycol, PG; vegetable glycerin, VG). Exposure to formaldehyde or PG-VG–derived aerosol alone stimulated ED in female mice. As ED was independent of nicotine and flavorants, these data reflect a “universal flaw” of E-cigs that use PG-VG.

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Hershberger, Alexandra, Miranda Connors, Miji Um, and Melissa A. Cyders. "The Theory of Planned Behavior and E-cig Use: Impulsive Personality, E-cig Attitudes, and E-cig Use." International Journal of Mental Health and Addiction 16, no. 2 (2017): 366–76. http://dx.doi.org/10.1007/s11469-017-9783-6.

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Olfert, I. Mark, Evan DeVallance, Hannah Hoskinson, et al. "Chronic exposure to electronic cigarettes results in impaired cardiovascular function in mice." Journal of Applied Physiology 124, no. 3 (2018): 573–82. http://dx.doi.org/10.1152/japplphysiol.00713.2017.

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Proponents for electronic cigarettes (E-cigs) claim that they are a safe alternative to tobacco-based cigarettes; however, little is known about the long-term effects of exposure to E-cig vapor on vascular function. The purpose of this study was to determine the cardiovascular consequences of chronic E-cig exposure. Female mice (C57BL/6 background strain) were randomly assigned to chronic daily exposure to E-cig vapor, standard (3R4F reference) cigarette smoke, or filtered air ( n = 15/group). Respective whole body exposures consisted of four 1-h-exposure time blocks, separated by 30-min inter

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Glynos, Constantinos, Sofia-Iris Bibli, Paraskevi Katsaounou, et al. "Comparison of the effects of e-cigarette vapor with cigarette smoke on lung function and inflammation in mice." American Journal of Physiology-Lung Cellular and Molecular Physiology 315, no. 5 (2018): L662—L672. http://dx.doi.org/10.1152/ajplung.00389.2017.

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Electronic cigarettes (e-cigs) are advertised as a less harmful nicotine delivery system or as a new smoking cessation tool. We aimed to assess the in vivo effects of e-cig vapor in the lung and to compare them to those of cigarette smoke (CS). We exposed C57BL/6 mice for either 3 days or 4 wk to ambient air, CS, or e-cig vapor containing 1) propylene glycol/vegetable glycerol (PG:VG-Sol; 1:1), 2) PG:VG with nicotine (G:VG-N), or 3) PG:VG with nicotine and flavor (PG:VG-N+F) and determined oxidative stress, inflammation, and pulmonary mechanics. E-cig vapors, especially PG:VG-N+F, increased br

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Kaur, Gagandeep, Rakeysha Pinkston, Benathel Mclemore, Waneene C. Dorsey, and Sanjay Batra. "Immunological and toxicological risk assessment of e-cigarettes." European Respiratory Review 27, no. 147 (2018): 170119. http://dx.doi.org/10.1183/16000617.0119-2017.

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Knowledge of the long-term toxicological and immunological effects of e-cigarette (e-cig) aerosols remains elusive due to the relatively short existence of vaping. Therefore, we performed a systematic search of articles published in public databases and analysed the research evidence in order to provide critical information regarding e-cig safety. Electronic nicotine delivery systems (or e-cigs) are an alternative to traditional cigarettes for the delivery of nicotine and are typically filled with glycerol or propylene glycol-based solutions known as e-liquids. Though present in lower quantiti

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Khosravi, M., R. L. Lin, and L. Y. Lee. "Inhalation of electronic cigarette aerosol induces reflex bronchoconstriction by activation of vagal bronchopulmonary C-fibers." American Journal of Physiology-Lung Cellular and Molecular Physiology 315, no. 4 (2018): L467—L475. http://dx.doi.org/10.1152/ajplung.00137.2018.

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The electronic cigarette (e-cig) has been suggested as a safer alternative to tobacco cigarettes. However, the health effects of e-cigs on the airways have not been fully investigated. Nicotine, the primary chemical constituent of the e-cig aerosol, has been shown to stimulate vagal bronchopulmonary C-fiber sensory nerves, which upon activation can elicit vigorous pulmonary defense reflexes, including airway constriction. In this study, we investigated the bronchomotor response to e-cig inhalation challenge in anesthetized guinea pigs and the mechanisms involved in regulating these responses.

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Noël, Alexandra, Shannon Hansen, Anusha Zaman, et al. "In utero exposures to electronic-cigarette aerosols impair the Wnt signaling during mouse lung development." American Journal of Physiology-Lung Cellular and Molecular Physiology 318, no. 4 (2020): L705—L722. http://dx.doi.org/10.1152/ajplung.00408.2019.

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Currently, more than 9 million American adults, including women of childbearing age, use electronic-cigarettes (e-cigs). Further, the prevalence of maternal vaping now approaching 10% is similar to that of maternal smoking. Little, however, is known about the effects of fetal exposures to nicotine-rich e-cig aerosols on lung development. In this study, we assessed whether in utero exposures to e-cig aerosols compromised lung development in mice. A third-generation e-cig device was used to expose pregnant BALB/c mice by inhalation to 36 mg/mL of nicotine cinnamon-flavored e-cig aerosols for 14–

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Escobar, Yael-Natalie H., Cameron B. Morrison, Yuzhi Chen, et al. "Differential responses to e-cig generated aerosols from humectants and different forms of nicotine in epithelial cells from nonsmokers and smokers." American Journal of Physiology-Lung Cellular and Molecular Physiology 320, no. 6 (2021): L1064—L1073. http://dx.doi.org/10.1152/ajplung.00525.2020.

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In the United States, millions of adults use electronic cigarettes (e-cigs), and a majority of these users are former or current cigarette smokers. It is unclear, whether prior smoking status affects biological responses induced by e-cigs. In this study, differentiated human nasal epithelial cells (hNECs) from nonsmokers and smokers at air-liquid interface were acutely exposed to the e-cig generated aerosols of humectants, propylene glycol (PG), and glycerol (GLY). Mucin levels were examined in the apical washes, and cytokine levels were assessed in the basolateral supernatants 24 h postexposu

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Rao, Poonam, Jiangtao Liu, and Matthew L. Springer. "JUUL and Combusted Cigarettes Comparably Impair Endothelial Function." Tobacco Regulatory Science 6, no. 1 (2020): 30–37. http://dx.doi.org/10.18001/trs.6.1.4.

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Objectives: JUUL and earlier generation electronic cigarettes (e-cigs) are promoted as being less hazardous than cigarettes. JUUL Labs, in particular, claims that switching from smoking to vaping has beneficial impacts; however, the health effects of such products are not well understood. We investigated whether exposure to JUUL and previous generation e-cig aerosol impairs endothelial function comparably to cigarette smoke. Methods: We exposed rats to aerosol from Virginia Tobacco flavor JUUL, an e-cig tank system using unflavored free-base nicotine e-liquid, Marlboro Red combustible tobacco

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Singh, Kameshwar P., Gina Lawyer, Thivanka Muthumalage, et al. "Systemic biomarkers in electronic cigarette users: implications for noninvasive assessment of vaping-associated pulmonary injuries." ERJ Open Research 5, no. 4 (2019): 00182–2019. http://dx.doi.org/10.1183/23120541.00182-2019.

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BackgroundElectronic cigarettes (e-cigs) were introduced as electronic nicotine delivery systems, and have become very popular in the USA and globally. There is a paucity of data on systemic injury biomarkers of vaping in e-cig users that can be used as a noninvasive assessment of vaping-associated lung injuries. We hypothesised that characterisation of systemic biomarkers of inflammation, anti-inflammatory, oxidative stress, vascular and lipid mediators, growth factors, and extracellular matrix breakdown may provide information regarding the toxicity of vaping in e-cig users.MethodsWe collect

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Lampos, Spyros, Evangelia Kostenidou, Konstantinos Farsalinos, et al. "Real-Time Assessment of E-Cigarettes and Conventional Cigarettes Emissions: Aerosol Size Distributions, Mass and Number Concentrations." Toxics 7, no. 3 (2019): 45. http://dx.doi.org/10.3390/toxics7030045.

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Cigarette smoke is a complex mixture of chemical compounds which are emitted during the processes of tobacco combustion. Electronic cigarettes (e-cigs) are expected to produce less harmful compounds due to the absence of tobacco leaf combustion. However, potential risks of the passive exposure to the aerosol exhaled by e-cig users have been raised in the last decade. In this study, the aerosols with diameter less than 1 μm (PM1) produced by vaping of various e-cig liquids were compared to those generated by smoking conventional cigarettes in real time. The mass and number concentration along w

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Lee, Abby C., Jaideep Chakladar, Wei Tse Li, et al. "Tobacco, but Not Nicotine and Flavor-Less Electronic Cigarettes, Induces ACE2 and Immune Dysregulation." International Journal of Molecular Sciences 21, no. 15 (2020): 5513. http://dx.doi.org/10.3390/ijms21155513.

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The COVID-19 pandemic caused by the SARS-CoV-2 virus, overlaps with the ongoing epidemics of cigarette smoking and electronic cigarette (e-cig) vaping. However, there is scarce data relating COVID-19 risks and outcome with cigarette or e-cig use. In this study, we mined three independent RNA expression datasets from smokers and vapers to understand the potential relationship between vaping/smoking and the dysregulation of key genes and pathways related to COVID-19. We found that smoking, but not vaping, upregulates ACE2, the cellular receptor that SARS-CoV-2 requires for infection. Both smokin

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Dyamenahalli, Kiran U., Derek M. Wengryn, Arek J. Wiktor, Elizabeth J. Kovacs, Patrick Duffy, and Anne L. Lambert Wagner. "64 E-cigarette and Vaporizer-related Burn Injury: Demographics and Injury Patterns." Journal of Burn Care & Research 41, Supplement_1 (2020): S42. http://dx.doi.org/10.1093/jbcr/iraa024.068.

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Abstract Introduction E-cigarettes and vaporizers (E-cigs) have seen a dramatic surge in popularity. The Centers for Disease Control now estimates that 1 in 4 United States (US) high school students use E-cigs. Recent recognition of E-cig-related lung injury has garnered significant attention. However, relatively little is known about E-cig-related burn injuries, which are often due to battery explosion and liquid ignition. The objective of this study was to characterize population demographics and injury patterns associated with E-cig burns. Methods A retrospective review of all patients pres

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Hobkirk, Andréa L., Zachary Bitzer, Reema Goel, et al. "An Electronic Aerosol Delivery System for Functional Magnetic Resonance Imaging." Substance Abuse: Research and Treatment 14 (January 2020): 117822182090414. http://dx.doi.org/10.1177/1178221820904140.

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Background: Public health concerns over the addictive potential of electronic cigarettes (e-cigs) have heightened in recent years. Brain function during e-cig use could provide an objective measure of the addictive potential of new vaping products to facilitate research; however, there are limited methods for delivering e-cig aerosols during functional magnetic resonance imaging (fMRI). The current study describes the development and feasibility testing of a prototype to deliver up to four different e-cig aerosols during fMRI. Methods: Standardized methods were used to test the devices’ air fl

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Zein, Ahmad Fariz Malvi Zamzam, Donny Nauphar, Uswatun Khasanah, et al. "The Association Between the Pattern of Electronic Cigarette Smoking and Gastroesophageal Reflux." Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy 22, no. 1 (2021): 16–20. http://dx.doi.org/10.24871/221202116-20.

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Background: This study was aimed to investigate the proportion of gastroesophageal reflux (GER) among electronic cigarette (e-cig) smokers and its association with the pattern of e-cig smoking.Method: This cross-sectional study underwent among e-cig smokers community in Cirebon City, Jawa Barat, ranged from March to August 2020. Subjects were enrolled through consecutive sampling method. The data collection used survey containing the pattern of e-cig smoking and GER. The pattern of e-cig smoking included the duration of e-cig smoking and the amount of e-cig smoking. Gastroesophageal reflux con

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Szafran, Brittany N., Rakeysha Pinkston, Zakia Perveen, et al. "Electronic-Cigarette Vehicles and Flavoring Affect Lung Function and Immune Responses in a Murine Model." International Journal of Molecular Sciences 21, no. 17 (2020): 6022. http://dx.doi.org/10.3390/ijms21176022.

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The use of electronic nicotine delivery systems (ENDS), also known as electronic-cigarettes (e-cigs), has raised serious public health concerns, especially in light of the 2019 outbreak of e-cig or vaping product use-associated acute lung injury (EVALI). While these cases have mostly been linked to ENDS that contain vitamin E acetate, there is limited research that has focused on the chronic pulmonary effects of the delivery vehicles (i.e., without nicotine and flavoring). Thus, we investigated lung function and immune responses in a mouse model following exposure to the nearly ubiquitous e-ci

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Wang, Qixin, Xiangming Ji, and Irfan Rahman. "Dysregulated Metabolites Serve as Novel Biomarkers for Metabolic Diseases Caused by E-Cigarette Vaping and Cigarette Smoking." Metabolites 11, no. 6 (2021): 345. http://dx.doi.org/10.3390/metabo11060345.

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Metabolites are essential intermediate products in metabolism, and metabolism dysregulation indicates different types of diseases. Previous studies have shown that cigarette smoke dysregulated metabolites; however, limited information is available with electronic cigarette (e-cig) vaping. We hypothesized that e-cig vaping and cigarette smoking alters systemic metabolites, and we propose to understand the specific metabolic signature between e-cig users and cigarette smokers. Plasma from non-smoker controls, cigarette smokers, and e-cig users was collected, and metabolites were identified by UP

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Coppeta, Luca, Andrea Magrini, Antonio Pietroiusti, Stefano Perrone, and Mario Grana. "Effects of Smoking Electronic Cigarettes on Pulmonary Function and Environmental Parameters." Open Public Health Journal 11, no. 1 (2018): 360–68. http://dx.doi.org/10.2174/1874944501811010360.

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Objectives:Our study aims to evaluate whether the active use of the electronic cigarette (e-cig) can determine adverse effects on the respiratory function of healthy workers and whether potentially dangerous pollutants are released in the air.Methods:Thirty healthy workers (seventeen men and thirteen women, age range 27-37) were included in the study. Immediately before and after a 5-minute smoking session performed in two different days (first-day e-cig, second-day tobacco cigarette [t-cig]), they underwent spirometry evaluation. Furthermore, environmental particle monitoring was performed du

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Nansseu, Jobert Richie N., and Jean Joel R. Bigna. "Electronic Cigarettes for Curbing the Tobacco-Induced Burden of Noncommunicable Diseases: Evidence Revisited with Emphasis on Challenges in Sub-Saharan Africa." Pulmonary Medicine 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/4894352.

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Introduction. This review examines whether electronic cigarettes (e-cigs) implementation or vulgarization in sub-Saharan Africa (SSA) could be helpful in curtailing the toll of tobacco smoking in the region. Discussion. There are about 1.3 billion smokers worldwide, with nearly 80% of them living in developing countries where the burden of tobacco-related illnesses and deaths is the heaviest. Studies report that e-cigs may facilitate smoking cessation, reduction, or abstinence and may pose only a small fraction of the risks of traditional tobacco cigarettes; e-cigs may also considerably reduce

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Chun, Lauren F., Farzad Moazed, Carolyn S. Calfee, Michael A. Matthay, and Jeffrey E. Gotts. "Pulmonary toxicity of e-cigarettes." American Journal of Physiology-Lung Cellular and Molecular Physiology 313, no. 2 (2017): L193—L206. http://dx.doi.org/10.1152/ajplung.00071.2017.

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Electronic cigarettes (e-cigarettes or e-cigs) are designed to heat and aerosolize mixtures of vegetable glycerin, propylene glycol, nicotine, and flavoring additives, thus delivering nicotine by inhalation in the absence of combustion. These devices were originally developed to facilitate smoking cessation and have been available in the United States for over a decade. Since 2010, e-cig use has expanded rapidly, especially among adolescents, despite a paucity of short- and long-term safety data. Patterns of use have shifted to include never smokers and many dual users of e-cigs and combustibl

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Cirillo, Silvia, Fabio Vivarelli, Eleonora Turrini, et al. "The Customizable E-cigarette Resistance Influences Toxicological Outcomes: Lung Degeneration, Inflammation, and Oxidative Stress-Induced in a Rat Model." Toxicological Sciences 172, no. 1 (2019): 132–45. http://dx.doi.org/10.1093/toxsci/kfz176.

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Abstract Despite the knowledge gap regarding the risk-benefit ratio of the electronic cigarette (e-cig), its use has grown exponentially, even in teenagers. E-cig vapor contains carcinogenic compounds (eg, formaldehyde, acetaldehyde, and acrolein) and free radicals, especially reactive oxygen species (ROS) that cause toxicological effects, including DNA damage. The role of e-cig voltage customization on molecule generation has been reported, but the effects of the resistance on e-cig emissions and toxicity are unknown. Here, we show that the manipulation of e-cig resistance influences the carb

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Schweitzer, Kelly S., Steven X. Chen, Sarah Law, et al. "Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures." American Journal of Physiology-Lung Cellular and Molecular Physiology 309, no. 2 (2015): L175—L187. http://dx.doi.org/10.1152/ajplung.00411.2014.

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The increased use of inhaled nicotine via e-cigarettes has unknown risks to lung health. Having previously shown that cigarette smoke (CS) extract disrupts the lung microvasculature barrier function by endothelial cell activation and cytoskeletal rearrangement, we investigated the contribution of nicotine in CS or e-cigarettes (e-Cig) to lung endothelial injury. Primary lung microvascular endothelial cells were exposed to nicotine, e-Cig solution, or condensed e-Cig vapor (1–20 mM nicotine) or to nicotine-free CS extract or e-Cig solutions. Compared with nicotine-containing extract, nicotine f

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Reilly, Samantha M., Zachary T. Bitzer, Reema Goel, Neil Trushin, and John P. Richie. "Free Radical, Carbonyl, and Nicotine Levels Produced by Juul Electronic Cigarettes." Nicotine & Tobacco Research 21, no. 9 (2018): 1274–78. http://dx.doi.org/10.1093/ntr/nty221.

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Abstract Introduction Free radicals and carbonyls produced by electronic cigarettes (e-cigs) have the potential to inflict oxidative stress. Recently, Juul e-cigs have risen drastically in popularity; however, there is no data on nicotine and oxidant yields from this new e-cig design. Methods Aerosol generated from four different Juul flavors was analyzed for carbonyls, nicotine, and free radicals. The e-liquids were analyzed for propylene glycol (PG) and glycerol (GLY) concentrations. To determine the effects of e-liquid on oxidant production, Juul pods were refilled with nicotine-free 30:70

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McDonough, Samantha R., Irfan Rahman, and Isaac Kirubakaran Sundar. "Recent updates on biomarkers of exposure and systemic toxicity in e-cigarette users and EVALI." American Journal of Physiology-Lung Cellular and Molecular Physiology 320, no. 5 (2021): L661—L679. http://dx.doi.org/10.1152/ajplung.00520.2020.

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Electronic nicotine delivery systems (ENDS), or e-cigarettes, are emerging tobacco products that produce aerosols by heating e-liquids, which most often consist of propylene glycol and vegetable glycerin along with various flavoring compounds, bypassing the combustion that occurs in the use of traditional tobacco cigarettes. These products have seen a drastic increase in popularity in recent years both as smoking cessation devices as well as among younger generations, due in large part to the widespread perception among consumers that e-cigs are significantly less harmful to health than tradit

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Ramanathan, Gajalakshmi, Brianna Craver-Hoover, Rebecca J. Arechavala, et al. "E-Cigarette Exposure Decreases Bone Marrow Hematopoietic Progenitor Cells." Cancers 12, no. 8 (2020): 2292. http://dx.doi.org/10.3390/cancers12082292.

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Electronic cigarettes (E-cigs) generate nicotine containing aerosols for inhalation and have emerged as a popular tobacco product among adolescents and young adults, yet little is known about their health effects due to their relatively recent introduction. Few studies have assessed the long-term effects of inhaling E-cigarette smoke or vapor. Here, we show that two months of E-cigarette exposure causes suppression of bone marrow hematopoietic stem and progenitor cells (HSPCs). Specifically, the common myeloid progenitors and granulocyte-macrophage progenitors were decreased in E-cig exposed a

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Tommasi, Stella, Andrew Caliri, Amanda Caceres, et al. "Deregulation of Biologically Significant Genes and Associated Molecular Pathways in the Oral Epithelium of Electronic Cigarette Users." International Journal of Molecular Sciences 20, no. 3 (2019): 738. http://dx.doi.org/10.3390/ijms20030738.

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We have investigated the regulation of genes and associated molecular pathways, genome-wide, in oral cells of electronic cigarette (e-cigs) users and cigarette smokers as compared to non-smokers. Interrogation of the oral transcriptome by RNA-sequencing (RNA-seq) analysis showed significant number of aberrantly expressed transcripts in both e-cig users (vapers) and smokers relative to non-smokers; however, smokers had ~50% more differentially expressed transcripts than vapers (1726 versus 1152). Whereas the deregulated transcripts in smokers were predominately from protein-coding genes (79% ve

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Ni, Fenge, Tatsuya Ogura, and Weihong Lin. "Electronic Cigarette Liquid Constituents Induce Nasal and Tracheal Sensory Irritation in Mice in Regionally Dependent Fashion." Nicotine & Tobacco Research 22, Supplement_1 (2020): S35—S44. http://dx.doi.org/10.1093/ntr/ntaa174.

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Abstract Introduction Electronic cigarettes (e-cigs) are currently used by millions of adults and adolescents worldwide. Major respiratory symptoms, such as coughing reported by e-cig users, including patients with e-cig, or vaping, product use-associated lung injury (EVALI), indicate e-cig constituent-induced sensory irritation. However, e-cig constituent-induced nociceptive activity in nasal and tracheal respiratory epithelia (RE) and neuronal activation in the trigeminal ganglia and brainstem nuclei, which receive airway chemosensory inputs have not been examined and compared. Comparisons o

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Johnston, Emily Jade, Katarzyna Campbell, Tim Coleman, Sarah Lewis, Sophie Orton, and Sue Cooper. "Safety of Electronic Cigarette Use During Breastfeeding: Qualitative Study Using Online Forum Discussions." Journal of Medical Internet Research 21, no. 8 (2019): e11506. http://dx.doi.org/10.2196/11506.

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Background Electronic cigarettes (e-cigs) are an increasingly popular alternative to smoking, helping to prevent relapse in those trying to quit and with the potential to reduce harm as they are likely to be safer than standard cigarettes. Many women return to smoking in the postpartum period having stopped during pregnancy, and while this can affect their decisions about breastfeeding, little is known about women’s opinions on using e-cigs during this period. Objective The aim of this study is to explore online forum users’ current attitudes, motivations, and barriers to postpartum e-cig use,

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Dewi, Desak Made Sintha Kurnia. "PENINGKATAN PENGETAHUAN REMAJA TENTANG BAHAYA ROKOK ELEKTRONIK." Journal of Community Mental Health and Public Policy 3, no. 1 (2021): 31–40. http://dx.doi.org/10.51602/cmhp.v3i1.46.

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ABSTRACTThe popularity of e-cigarette (e-cig) is increasing among adolescents, as it is promoted as a safer cigarette and a tool that can help to quit smoking. The misleading security illusion of e-cig without adequate knowledge has created a new generation of tobacco industry customers. The aim is to improve adolescent knowledge about the harmful effects e-cig. Online socialization about the electronic cigarette traps were given to junior and senior high school students in two sub districts in Banyuwangi. Education was conducted in October 2020, attended by 107 students and 15 teachers.Three

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Chen, Leo, Nai Wen Wang, and Winson Y. Cheung. "A comparison of risk factors for cigarette and e-cigarette use in the United States adult population." Journal of Clinical Oncology 37, no. 15_suppl (2019): 1546. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.1546.

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1546 Background: The US CDC and public health agencies have reported alarming increases in e-cigarette (ecig) use among youth, even as cigarette (cig) use among youth decline. In this study, other risk factors for cig and ecig use are compared. Methods: This study used data from the Health Information National Trends Survey 5 Cycle 1 survey, conducted in 2017. Univariate survey-weighted logistic regression analyzed responses as a nationally representative US population. Results: Inverted trends included being 35 or older (cig: OR=1.22, p<0.01; ecig: OR=0.79, p<0.01), being a student (cig

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Chatterjee, Shampa, Jian-Qin Tao, Alyssa Johncola, et al. "Acute exposure to e-cigarettes causes inflammation and pulmonary endothelial oxidative stress in nonsmoking, healthy young subjects." American Journal of Physiology-Lung Cellular and Molecular Physiology 317, no. 2 (2019): L155—L166. http://dx.doi.org/10.1152/ajplung.00110.2019.

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The effects of e-cigarette (e-cig) aerosol inhalation by nonsmokers have not been examined to date. The present study was designed to evaluate the acute response to aerosol inhalation of non-nicotinized e-cigarettes in terms of oxidative stress and indices of endothelial activation in human pulmonary microvascular endothelial cells (HPMVEC). Ten smoking-naïve healthy subjects (mean age ± SD = 28.7 ± 5.5 yr) were subjected to an e-cig challenge, following which their serum was monitored for markers of inflammation [C-reactive protein (CRP) and soluble intercellular adhesion molecule (sICAM)] an

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Morales Velásquez, Mateo, Jenniffer Puerta Suarez, and Walter D. Cardona Maya. "Efecto del Cigarrillo Electrónico sobre los Espermatozoides Humanos: Aproximación in vitro." Revista Urología Colombiana / Colombian Urology Journal 29, no. 01 (2019): 007–13. http://dx.doi.org/10.1055/s-0039-1691783.

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Resumen Introducción Los cigarrillos electrónicos (E-Cig) aparecieron en el mercado hace 15 años como una alternativa para combatir el consumo de tabaco, un problema de salud pública, sin embargo, su efecto sobre la salud reproductiva no ha sido completamente evaluado. El objetivo del presente estudio, fue evaluar los efectos de los E-Cig sobre los espermatozoides humanos in vitro. Métodos Un dispositivo para incubar en contacto directo a los espermatozoides con el vapor a partir de dos esencias diferentes (TNT y Sugar Drizzle), el humo del cigarrillo o aire como control negativo fue construid

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Alhaddad, Hasan, Woonyen Wong, Adam T. Sari, Laura E. Crotty Alexander, and Youssef Sari. "Effects of 3-Month Exposure to E-Cigarette Aerosols on Glutamatergic Receptors and Transporters in Mesolimbic Brain Regions of Female C57BL/6 Mice." Toxics 8, no. 4 (2020): 95. http://dx.doi.org/10.3390/toxics8040095.

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Electronic cigarettes (e-cigs) use has been dramatically increased recently, especially among youths. Previous studies from our laboratory showed that chronic exposure to e-cigs, containing 24 mg/mL nicotine, was associated with dysregulation of glutamate transporters and neurotransmitter levels in the brain of a mouse model. In this study, we evaluated the effect of three months’ continuous exposure to e-cig vapor (JUUL pods), containing a high nicotine concentration, on the expression of glutamate receptors and transporters in drug reward brain regions such as the nucleus accumbens (NAc) cor

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Beatrice, Fabio, and Giuseppina Massaro. "Exhaled Carbon Monoxide Levels in Forty Resistant to Cessation Male Smokers after Six Months of Full Switch to Electronic Cigarettes (e-Cigs) or to A Tobacco Heating Systems (THS)." International Journal of Environmental Research and Public Health 16, no. 20 (2019): 3916. http://dx.doi.org/10.3390/ijerph16203916.

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Cigarette smoke releases several toxic chemicals and carcinogens including carbon monoxide (CO). This study examined the levels of exhaled CO in smokers switching to electronic cigarettes (e-Cigs) or a tobacco heating system (THS) and their level of compliance six months after switching. On the basis of their own preferences, 40 male smokers unwilling or unable to stop smoking were switched to e-Cigs or THSs for six months (20 subjects in each group). Nicotine addiction and levels of carbon monoxide in the exhaled breath (eCO) were measured at baseline (the latter also at six months). The Shap

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Acharya, D. K. "E-cigarettes: Do They Have Any Role in Tobacco Control?" Journal of Global Oncology 4, Supplement 2 (2018): 130s. http://dx.doi.org/10.1200/jgo.18.52500.

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Introduction: and objective: E-cigarettes -an entity, unheard of until a few years ago, has taken up the market in a big way. They are being aggressively marketed all over the world, are being increasingly used by smokers as well as new vapers because of its easy availability and no regulation on its sale or use. These gadgets come in nearly 250 varieties and are being frequently upgraded. Methods: The promoters of e-cigs claim that it exposes the user and persons around them to much lesser degrees of nicotine and other chemicals, which is definitely far less toxic then the cigarette smoke. It

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Guthery, W., and MJ Taylor. "Quantitative Analysis of Polycyclic Aromatic Hydrocarbons (PAHs) Cited by the United States Food and Drug Administration." Beiträge zur Tabakforschung International/Contributions to Tobacco Research 25, no. 6 (2013): 607–16. http://dx.doi.org/10.2478/cttr-2013-0937.

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AbstractThe yields of 16 polycyclic aromatic hydrocarbons (PAHs) were determined from cigarette mainstream smoke condensate extracts using Gas Chromatography- Tandem Mass Spectrometry (GC-MS/MS). The method has been validated for ISO and Health Canada Intense (HCI) smoking protocols. Quantifiable levels (ISO means 0.16 to 365 ng/cig; HCI means 0.33 to 1595 ng/cig; n = 30) of 15 PAHs were found in the Kentucky reference cigarette K3R4F. The coefficient of variance (CV) was derived from ten determinations each run in triplicate. The CV range was 8.7% to 24.8% (ISO) and 6.6% to 24.3% (HCI). The l

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Palmisani, Jolanda, Alessia Di Gilio, Laura Palmieri, et al. "Evaluation of Second-Hand Exposure to Electronic Cigarette Vaping under a Real Scenario: Measurements of Ultrafine Particle Number Concentration and Size Distribution and Comparison with Traditional Tobacco Smoke." Toxics 7, no. 4 (2019): 59. http://dx.doi.org/10.3390/toxics7040059.

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The present study aims to evaluate the impact of e-cig second-hand aerosol on indoor air quality in terms of ultrafine particles (UFPs) and potential inhalation exposure levels of passive bystanders. E-cig second-hand aerosol characteristics in terms of UFPs number concentration and size distribution exhaled by two volunteers vaping 15 different e-liquids inside a 49 m3 room and comparison with tobacco smoke are discussed. High temporal resolution measurements were performed under natural ventilation conditions to simulate a realistic exposure scenario. Results showed a systematic increase in

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Phung, Binh, and Anh Lam. "Pediatric Acute Respiratory Distress Syndrome and Hypersensitivity Pneumonitis Related to E-cigarette Vaping." Journal of Pediatric Intensive Care 09, no. 02 (2019): 128–34. http://dx.doi.org/10.1055/s-0039-3400961.

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AbstractIn recent years, electronic cigarettes (e-cigs) have been falsely advertised as safe alternatives to conventional smoking. We report a case involving a 16-year-old female who presented with fever, nonproductive cough, and shortness of breath after vaping e-cig/tetrahydrocannabinol dab pen. Her symptoms rapidly deteriorated and met diagnostic criteria for pediatric acute respiratory distress syndrome. Chest radiograph revealed extensive patchy airspace disease and computed tomography scan showed bilateral ground glass opacities. Bronchoalveolar lavage fluid revealed increased neutrophil

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Vivarelli, Fabio, Donatella Canistro, Silvia Cirillo, Vladimiro Cardenia, Maria Teresa Rodriguez-Estrada, and Moreno Paolini. "Impairment of testicular function in electronic cigarette (e-cig, e-cigs) exposed rats under low-voltage and nicotine-free conditions." Life Sciences 228 (July 2019): 53–65. http://dx.doi.org/10.1016/j.lfs.2019.04.059.

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Protano, Carmela, Pasquale Avino, Maurizio Manigrasso, et al. "Environmental Electronic Vape Exposure from Four Different Generations of Electronic Cigarettes: Airborne Particulate Matter Levels." International Journal of Environmental Research and Public Health 15, no. 10 (2018): 2172. http://dx.doi.org/10.3390/ijerph15102172.

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Electronic cigarettes (e-cigs) were introduced into the market in 2006 and their technological features have evolved substantially over time. Currently, there are four different generations of e-cigs that are broadly considered less harmful than the use of combusted tobacco products although passive exposure to aerosols often occurs in public spaces and indoor environments. The study aim was to evaluate the levels of airborne particulate matter (PM) emitted during the use of all the four generations of e-cigs, testing different use modalities. PM10, PM4, PM2.5 and PM1 were measured through a D

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Kaur, Gagandeep, Kameshwar Singh, Krishna P. Maremanda, Dongmei Li, Hitendra S. Chand, and Irfan Rahman. "Differential plasma exosomal long non-coding RNAs expression profiles and their emerging role in E-cigarette users, cigarette, waterpipe, and dual smokers." PLOS ONE 15, no. 12 (2020): e0243065. http://dx.doi.org/10.1371/journal.pone.0243065.

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Long non-coding RNAs (lncRNAs) are the varied set of transcripts that play a critical role in biological processes like gene regulation, transcription, post-transcriptional modification, and chromatin remodeling. Recent studies have reported the presence of lncRNAs in the exosomes that are involved in regulating cell-to-cell communication in lung pathologies including lung cancer, chronic obstructive pulmonary disease (COPD), asthma, and idiopathic pulmonary fibrosis (IPF). In this study, we compared the lncRNA profiles in the plasma-derived exosomes amongst non-smokers (NS), cigarette smokers

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Hamad, Samera H., Marielle C. Brinkman, Yi-Hsuan Tsai, et al. "Pilot Study to Detect Genes Involved in DNA Damage and Cancer in Humans: Potential Biomarkers of Exposure to E-Cigarette Aerosols." Genes 12, no. 3 (2021): 448. http://dx.doi.org/10.3390/genes12030448.

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There is a paucity of data on how gene expression enables identification of individuals who are at risk of exposure to carcinogens from e-cigarette (e-cig) vaping; and how human vaping behaviors modify these exposures. This pilot study aimed to identify genes regulated from acute exposure to e-cig using RT-qPCR. Three subjects (2M and 1F) made three visits to the lab (nTOT = 9 visits); buccal and blood samples were collected before and immediately after scripted vaping 20 puffs (nTOT = 18 samples); vaping topography data were collected in each session. Subjects used their own e-cig containing

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Hunt, Kate, and Helen Sweeting. "You have been QUALIFIED for a smokeless e-cig starter kit." Journal of Epidemiology and Community Health 68, no. 8 (2014): 786. http://dx.doi.org/10.1136/jech-2014-203879.

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