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Journal articles on the topic '[e]h08 ac t'

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Published: 27 July 2024

Last updated: 30 July 2024

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1

Khodabandeh, Masih, Mohammad Reza Zolghadri, Mahmood Shahbazi, and Negar Noroozi. "T‐type direct AC/AC converter structure." IET Power Electronics 9, no. 7 (2016): 1426–36. http://dx.doi.org/10.1049/iet-pel.2015.0151.

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Chaput, Jean-Philippe. "Obésité et modernité : l’émergence de nouveaux stimuli nous amène-t-elle à redéfinir la notion de sédentarité?" Applied Physiology, Nutrition, and Metabolism 33, no. 6 (2008): 1257–58. http://dx.doi.org/10.1139/h08-090.

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La mondialisation des marchés impose une pression accrue envers la performance, la productivité et la profitabilité des entreprises. Cette nouvelle réalité se traduit, entre autres, par une accentuation du travail du savoir ainsi que par une diminution du temps passé au lit. De plus, l’activité physique peut être considérée à juste titre comme une composante du mode de vie qui a été malheureusement laissée de côté et qui doit être minimalement réinsérée dans les activités de tous les jours. En effet, l’activité physique est porteuse d’une stimulation corporelle qui affecte significativement le

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Biondo, Patricia D., Sarah J. Robbins, Jennifer D. Walsh, Linda J. McCargar, Vicki J. Harber, and Catherine J. Field. "A randomized controlled crossover trial of the effect of ginseng consumption on the immune response to moderate exercise in healthy sedentary men." Applied Physiology, Nutrition, and Metabolism 33, no. 5 (2008): 966–75. http://dx.doi.org/10.1139/h08-080.

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Ginseng is a popular herbal remedy that is reputed to increase resistance to stress and improve immune function. Regular exercise results in acute physiologic stress that affects the immune response. This study was conducted to investigate the effects of daily consumption of a standardized ginsenoside-containing North American ginseng (Panax quinquefolius) extract on immune function before, during, and after a moderate-exercise protocol in healthy sedentary men. Ten healthy males were randomized to receive either ginseng (1125 mg·d–1) or placebo for 35 days. After a 3 month washout period, sub

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Midgley, Adrian W., Sean Carroll, David Marchant, Lars R. McNaughton, and Jason Siegler. "Evaluation of true maximal oxygen uptake based on a novel set of standardized criteria." Applied Physiology, Nutrition, and Metabolism 34, no. 2 (2009): 115–23. http://dx.doi.org/10.1139/h08-146.

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In this study, criteria are used to identify whether a subject has elicited maximal oxygen uptake. We evaluated the validity of traditional maximal oxygen uptake criteria and propose a novel set of criteria. Twenty athletes completed a maximal oxygen uptake test, consisting of an incremental phase and a subsequent supramaximal phase to exhaustion (verification phase). Traditional and novel maximal oxygen uptake criteria were evaluated. Novel criteria were: oxygen uptake plateau defined as the difference between modelled and actual maximal oxygen uptake >50% of the regression slope of the in

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He, Zihong, Yang Hu, Lianshi Feng, et al. "Association between HMOX-1 genotype and cardiac function during exercise." Applied Physiology, Nutrition, and Metabolism 33, no. 3 (2008): 450–60. http://dx.doi.org/10.1139/h08-016.

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The human gene for heme oxygenase-1 (HMOX-1) plays an important role in the regulation of cardiovascular function and its adaptive response to a variety of stressors. The purpose of this study was to examine the possible association between HMOX-1 genotypes (for –1135A/G, –413A/T, and rs5755720 polymorphisms) and cardiac structural and functional parameters at rest and during submaximal cycle-ergometer exercise (50, 100, and 150 W) in a pre-training state (baseline) and after endurance training (18 weeks, 95%~105% individual ventilatory threshold). The study population consisted of 102 Chinese

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Buford, Thomas W., and Darryn S. Willoughby. "Impact of DHEA(S) and cortisol on immune function in aging: a brief review." Applied Physiology, Nutrition, and Metabolism 33, no. 3 (2008): 429–33. http://dx.doi.org/10.1139/h08-013.

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A decline in the human immune system that occurs with aging is known as immunosenescence. Several factors are involved in the process, including reduced neutrophil function and cytotoxic capacity of natural killer (NK) cells, thymus atrophy and reduced naïve T cell number, and lowered B cell antibody production in response to antigen. The endocrine system, specifically the hypothalamus–pituitary–adrenal axis, plays an important role in modulating immune function. With aging an imbalance occurs between two adrenal hormones, cortisol and DHEA, that have opposing actions on immune function. This

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Zhang, Liying, Takayuki Tokoroyama, Yusei Yamada, Motoyuki Murashima, and Noritsugu Umehara. "The Micro-meter-sized plastic texture made by PVC with carbon black and AC electric field to enhance thermal conductivity." Proceedings of the Conference on Information, Intelligence and Precision Equipment : IIP 2022 (2022): IIP2R3—H08. http://dx.doi.org/10.1299/jsmeiip.2022.iip2r3-h08.

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8

Tse, Sirius Pui-kam, Fred Wang-fat Lee, Daniel Yun-lam Mak, et al. "Production of Paralytic Shellfish Toxins (PSTs) in Toxic Alexandrium catenella is Intertwined with Photosynthesis and Energy Production." Toxins 12, no. 8 (2020): 477. http://dx.doi.org/10.3390/toxins12080477.

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To investigate the mechanism for the production of paralytic shellfish toxins (PST) in toxic dinoflagellates, with a 2D-gel based approach, we had made two sets of proteomic comparisons: (a) between a toxic Alexandrium catenella (AC-T) and a phylogenetically closely related non-toxic strain (AC-N), (b) between toxic AC-T grown in a medium with 10% normal amount of phosphate (AC-T-10%P) known to induce higher toxicity and AC-T grown in normal medium. We found that photosynthesis and energy production related proteins were up-regulated in AC-T when compared to AC-N. However, the same group of pr

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Kozako, Tomohiro, Masaki Akimoto, Izumi Masamoto, et al. "The Frequency, Diversity, and Function of Human T-Cell Leukemia Virus Type 1-Specific CD8+ T-Cell Is Reduced in Adult T-Cell Leukemia Patients." Blood 108, no. 11 (2006): 1264. http://dx.doi.org/10.1182/blood.v108.11.1264.1264.

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Abstract Human T-cell lymphotropic virus type 1 (HTLV-1)-specific CTL are thought to be immune effectors that reduce the risk of adult T-cell leukemia (ATL). However, in vivo conditions of anti-HTLV-1 CTL before and after ATL development have yet to be determined. To characterize anti-HTLV-1 CTL in asymptomatic HTLV-1 carriers (AC) and ATL patients, we analyzed the frequency and diversity of HTLV-1-specific CD8+ T cells in PBMC of 35 AC and 32 ATL patients using 16 distinct epitopes of HTLV-1 Tax or Env/HLA tetramers along with intracellular cytolytic effector molecules (IFN-γ , perforin, and

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Lin, Hsin-Fu, Ching-Ying Tseng, Toby Mündel, et al. "Perturbations of Adjuvant Chemotherapy on Cardiovascular Responses and Exercise Tolerance in Patients with Early-Stage Breast Cancer." Biology 10, no. 9 (2021): 910. http://dx.doi.org/10.3390/biology10090910.

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Background: Adjuvant chemotherapies are commonly used for treating early-stage breast cancer. However, whether chemotherapeutic regimens affect exercise tolerance and cardiovascular responses remains unclear. Therefore, we investigated the effects of receiving CAF and AC-T on exercise tolerance and cardiovascular responses in patients with early-stage breast cancer. Methods: Thirty-four patients with breast cancer (age: 44 ± 1 years; stage I-II) received either CAF (n = 15) or AC-T (n = 19), depending on clinical decisions. Their step-exercise tolerance and cardiovascular responses were assess

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Burnell, M. J., M. N. Levine, J. A. Chapman, et al. "A phase III adjuvant trial of sequenced EC + filgrastim + epoetin-alpha followed by paclitaxel compared to sequenced AC followed by paclitaxel compared to CEF in women with node-positive or high-risk node-negative breast cancer (NCIC CTG MA.21)." Journal of Clinical Oncology 25, no. 18_suppl (2007): 550. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.550.

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550 Background: CEF and AC followed by paclitaxel (AC/T) are commonly used adjuvant regimens in women with early breast cancer. In a trial conducted by the EORTC, NCIC CTG, and SAKK three months of dose-dense EC was equivalent to six months of CEF in women with locally advanced breast cancer. We hypothesized that three months of a taxane following dose-dense EC would be superior to CEF alone or AC/T. The results of a planned interim analysis were presented in San Antonio 2006 (Abstract #53). We now present more detailed results on efficacy and toxicity. Methods: Women 60 years of age or younge

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Alawneh, Mai, Haithem Soliman, and Ania Anthony. "Characterizing the Effect of Freeze–Thaw Cycling on Pore Structure of Asphalt Concrete Mixtures Using X-ray CT Scanning." Materials 16, no. 18 (2023): 6254. http://dx.doi.org/10.3390/ma16186254.

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Freeze–thaw (F–T) cycling presents a challenge when building durable pavement structures in cold regions. Understanding the changes within the microstructure of asphalt concrete (AC) due to F–T conditions is crucial for developing a resilient pavement design. This study investigates the impact of F–T cycles on five AC mixtures using X-ray computed tomography (CT) scanning. Image analysis was completed to evaluate the changes in the microstructure of the AC samples before and after exposure to 30, 60, and 90 F–T cycles. The changes/degradation in the microstructure were evaluated based on analy

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Giannaki, Christoforos D., David Oxborough, and Keith George. "Diastolic Doppler flow and tissue Doppler velocities during, and in recovery from, low-intensity supine exercise." Applied Physiology, Nutrition, and Metabolism 33, no. 5 (2008): 896–902. http://dx.doi.org/10.1139/h08-078.

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Recent studies have reported evidence of both a short-term and a more sustained reduction in left ventricular diastolic function after prolonged strenuous exercise. Interpretation of this data is confounded by alterations in heart rate (HR) post-exercise. The purpose of this study was to investigate the association between HR and diastolic function during recovery from supine exercise, and to reassess the impact of increasing HR on early diastolic flow and tissue velocities during supine exercise. Repeat echocardiograms in 16 young, trained, volunteers were obtained at rest (50 ± 6 beats·min–1

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Burnell, Margot, Mark N. Levine, Judith-Anne W. Chapman, et al. "Cyclophosphamide, Epirubicin, and Fluorouracil Versus Dose-Dense Epirubicin and Cyclophosphamide Followed by Paclitaxel Versus Doxorubicin and Cyclophosphamide Followed by Paclitaxel in Node-Positive or High-Risk Node-Negative Breast Cancer." Journal of Clinical Oncology 28, no. 1 (2010): 77–82. http://dx.doi.org/10.1200/jco.2009.22.1077.

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Purpose Cyclophosphamide, epirubicin, and fluorouracil (CEF) and doxorubicin and cyclophosphamide (AC) followed by paclitaxel (T) are commonly used adjuvant regimens in women with early breast cancer. In a previous trial in women with locally advanced breast cancer, 3 months of high-dose epirubicin and cyclophosphamide (EC) administered every 2 weeks (dose-dense) was equivalent to 6 months of CEF. We hypothesized that 3 months of paclitaxel after dose-dense EC (EC/T) would be superior to CEF or AC/T. Methods After lumpectomy or mastectomy, women 60 years of age or younger with axillary node-po

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Lee, Rachel C., Ru-Dong Wei, and Fun S. Chu. "Enzyme-Linked Immunosorbent Assay for T-2 Toxin Metabolites in Urine." Journal of AOAC INTERNATIONAL 72, no. 2 (1989): 345–48. http://dx.doi.org/10.1093/jaoac/72.2.345.

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Abstract A direct competitive enzyme-linked immunosorbent assay (ELISA) for determination of total T-2 toxin metabolites in urine was developed. The assay involves coating anti-3-acetyl-neosolaniol-hemisuccinate- bovine serum albumin conjugate (anti-3-Ac-NEOS-HS-BSA) antibody to the ELISA plate and using 3-Ac-NEOS-HS-peroxidase as the enzyme marker. Competitive ELISA revealed that the antibody had good cross-reactivity with acetyldiacetoxyscirpenol (Ac-DAS), T-2 tetraol tetraacetate, 3'-OH-Ac-T-2, 3-Ac-NEOS, and 3,4,15- triacetyl-12,13-epoxytrichothec-9-en-8-one (Ac-T-2-8-one), but less cross-

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Via, C. S., G. C. Tsokos, N. I. Stocks, M. Clerici, and G. M. Shearer. "Human in vitro allogeneic responses. Demonstration of three pathways of T helper cell activation." Journal of Immunology 144, no. 7 (1990): 2524–28. http://dx.doi.org/10.4049/jimmunol.144.7.2524.

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Abstract In our study, we have measured in vitro proliferation and IL-2 production by human PBL to characterize the interactions between Th cells and accessory cells (AC) involved in responses to either conventional Ag or alloantigens. IL-2 production and proliferative responses to conventional Ag, such as influenza or tetanus, are exclusively dependent on the presence of CD4+ T cells and AC. In contrast, IL-2 and proliferative responses to alloantigen can be mediated by either CD4+ or CD8+ T cells. CD4+ T cells respond to alloantigen using either autologous AC (self-restricted), or allogeneic

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Cole, B. C., B. A. Araneo, and G. J. Sullivan. "Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis. IV. Murine T hybridoma cells exhibit differential accessory cell requirements for activation by M. arthritidis T cell mitogen, concanavalin A, or hen egg-white lysozyme." Journal of Immunology 136, no. 10 (1986): 3572–78. http://dx.doi.org/10.4049/jimmunol.136.10.3572.

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Abstract A T-cell mitogen present in culture supernatants of Mycoplasma arthritidis (MAS) is known to exhibit an absolute dependence on E alpha-bearing accessory cells (AC), which appear to function by binding the mitogen. We therefore compared the specificity and nature of the AC requirements for MAS and antigen-induced production of IL 2 in T hybridoma cell lines originating from a fusion by using hen egg-white lysozyme (HEL)-specific, H-2d-restricted T blasts. A marked specificity was noted in the ability of the hybridoma lines to become activated by Con A, MAS, or HEL antigen. Thus all thr

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Shulman, Lawrence N., Donald A. Berry, Constance T. Cirrincione, et al. "Comparison of Doxorubicin and Cyclophosphamide Versus Single-Agent Paclitaxel As Adjuvant Therapy for Breast Cancer in Women With 0 to 3 Positive Axillary Nodes: CALGB 40101 (Alliance)." Journal of Clinical Oncology 32, no. 22 (2014): 2311–17. http://dx.doi.org/10.1200/jco.2013.53.7142.

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Purpose Optimal adjuvant chemotherapy for early-stage breast cancer balances efficacy and toxicity. We sought to determine whether single-agent paclitaxel (T) was inferior to doxorubicin and cyclophosphamide (AC), when each was administered for four or six cycles of therapy, and whether it offered less toxicity. Patients and Methods Patients with operable breast cancer with 0 to 3 positive nodes were enrolled onto the study to address the noninferiority of single-agent T to AC, defined as the one-sided 95% upper-bound CI (UCB) of hazard ratio (HR) of T versus AC less than 1.30 for the primary

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Bekoff, M., T. Kakiuchi, and H. M. Grey. "Accessory cell function in the Con A response: role of Ia-positive and Ia-negative accessory cells." Journal of Immunology 134, no. 3 (1985): 1337–42. http://dx.doi.org/10.4049/jimmunol.134.3.1337.

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Abstract We have examined the role of Ia-positive and Ia-negative accessory cells (AC) and soluble factors in Con A-stimulated murine T cell activation. Supernatant fluids containing interleukin 1 (IL 1) derived from the P388D1 macrophage cell line and from a lipopolysaccharide (LPS)-stimulated macrophage hybridoma provided only partial reconstitution of the response of purified T cells (18 to 27%). The complete reconstitution obtained with gamma-irradiated spleen cells or LPS-activated B cells was inhibited by approximately 60 to 77% when anti-Ia antibody was included in the culture. Despite

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Sun, Yun-Lei, and En-Jia Ye. "Linear AC transport in T-stub and crossed silicene nanosystems." International Journal of Modern Physics B 32, no. 03 (2018): 1850016. http://dx.doi.org/10.1142/s0217979218500169.

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In this work, we theoretically study the linear AC transport properties in T-stub and crossed zigzag silicene nanosystems. The DC conductance and AC emittance are numerically calculated based on the tight-binding approach and AC transport theory, by considering the nearest-neighbor hopping, second-nearest-neighbor spin-orbit interaction (SOI) and external electric field. The relatively strong SOI of silicene was demonstrated to induce a topological quantum edge state in the nanosystems by the local density of states, which eliminates the AC emittance response at the Dirac point. Further invest

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CHUNG, J. Y., W. G. KHO, S. Y. HWANG, et al. "Molecular determination of the origin of acephalic cysticercus." Parasitology 130, no. 2 (2004): 239–46. http://dx.doi.org/10.1017/s0031182004006262.

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Acephalic cysticercus (Ac), a rarely developed multilobulated and nonencysted form of larval Taenia, causes hydrocephalus or adhesive arachnoiditis in the ventricles and subarachnoidal space that often lead to fatal outcome in affected patients. Ac has been proposed to originate from T. solium on the basis of morphological features, while no molecular data supporting the presumption have been available. In the present study, we investigated the immunological properties as well as molecular characteristics of Ac that was obtained surgically from 6 patients. Immunoblotting of the cyst fluid from

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Shulman, Lawrence N., Donald A. Berry, Constance T. Cirrincione, et al. "Comparison of doxorubicin and cyclophosphamide (AC) versus single-agent paclitaxel (T) as adjuvant therapy for breast cancer in women with 0-3 positive axillary nodes: CALGB 40101." Journal of Clinical Oncology 31, no. 15_suppl (2013): 1007. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.1007.

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1007 Background: Determining optimal adjuvant chemotherapy for early stage breast cancer depends on efficacy and toxicity. We sought to determine if T is equivalent to AC but with reduced toxicity. Methods: Pts with operable breast cancer with 0-3 positive nodes were enrolled on a 2x2 factorial design study which addressed (1) superiority of 6 vs. 4 cycles of therapy (previously reported, Shulman, JCO 2012) and (2) equivalence of single-agent T to standard AC, defined as upper bound of 95% confidence interval (CI) of hazard ratio (HR) of T vs. AC < 1.30 for the primary endpoint of relapse-f

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McElroy, Taylor, Taurean Brown, Fred Kiffer, et al. "Assessing the Effects of Redox Modifier MnTnBuOE-2-PyP 5+ on Cognition and Hippocampal Physiology Following Doxorubicin, Cyclophosphamide, and Paclitaxel Treatment." International Journal of Molecular Sciences 21, no. 5 (2020): 1867. http://dx.doi.org/10.3390/ijms21051867.

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Background: Chemotherapy treatment for breast cancer can induce cognitive impairments often involving oxidative stress. The brain, as a whole, is susceptible to oxidative stress due to its high-energy requirements, limited anaerobic respiration capacities, and limited antioxidant defenses. The goal of the current study was to determine if the manganese porphyrin superoxide dismutase mimetic MnTnBuOE-2-PyP (MnBuOE) could ameliorate the effects of doxorubicin, cyclophosphamide, and paclitaxel (AC-T) on mature dendrite morphology and cognitive function. Methods: Four-month-old female C57BL/6 mice

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Davis, L., and P. E. Lipsky. "Signals involved in T cell activation. II. Distinct roles of intact accessory cells, phorbol esters, and interleukin 1 in activation and cell cycle progression of resting T lymphocytes." Journal of Immunology 136, no. 10 (1986): 3588–96. http://dx.doi.org/10.4049/jimmunol.136.10.3588.

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Abstract The signals involved in the initiation of mitogen-induced activation of resting guinea pig T cells were examined. The combination of phytohemagglutinin (PHA) and 4 beta-phorbol 12-myristate 13-acetate (PMA) stimulated DNA synthesis by accessory cell (AC)-depleted T cells cultured at high density, but the use of low density cultures indicated that intact AC were absolutely necessary for PHA-stimulated T cell DNA synthesis even in the presence of PMA, interleukin 1 (IL 1), or interleukin 2 (IL 2). In contrast, AC-depleted T cells were able to respond to the combination of the calcium io

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Bear, Harry D., Stewart Anderson, Roy E. Smith, et al. "Sequential Preoperative or Postoperative Docetaxel Added to Preoperative Doxorubicin Plus Cyclophosphamide for Operable Breast Cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B-27." Journal of Clinical Oncology 24, no. 13 (2006): 2019–27. http://dx.doi.org/10.1200/jco.2005.04.1665.

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Purpose This study was designed to determine the effect of adding docetaxel (T) to preoperative doxorubicin and cyclophosphamide (AC) on breast cancer response rates and disease-free survival (DFS) and overall survival (OS). Patients and Methods Women with operable breast cancer (N = 2,411) were randomly assigned to receive preoperative AC followed by surgery, AC followed by T and surgery, or AC followed by surgery and then T. Tamoxifen was initiated concurrently with chemotherapy. Median time on study for 2,404 patients with follow-up was 77.9 months. Results Addition of T to AC did not signi

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van Kempen, Theo A. T. G., Samuel Benítez Puñal, Jet Huijser, and Stefaan De Smet. "Tocopherol more bioavailable than tocopheryl-acetate as a source of vitamin E for broilers." PLOS ONE 17, no. 5 (2022): e0268894. http://dx.doi.org/10.1371/journal.pone.0268894.

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Vitamin E is typically supplied in the form of tocopheryl-acetate (T-Ac) since tocopherol (T) has stability issues. Tocopheryl-acetate, however, must be hydrolyzed in the intestines before it can be absorbed, a step that is purportedly rate-limiting for its bioavailability. The objective of this study was to compare the efficiency of absorption of T-Ac and T in broilers. In addition, two test procedures were evaluated in which animals received the test substances for either 2 or 4 days only. Animals were adapted to diets without supplemental vitamin E (feedstuffs contributed 14±1 ppm natural v

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Shave, Rob, Keith George, Greg Whyte, et al. "A comparison of Doppler, tissue Doppler imaging, and strain rate imaging in the assessment of postexercise left ventricular function." Applied Physiology, Nutrition, and Metabolism 34, no. 1 (2009): 33–39. http://dx.doi.org/10.1139/h08-127.

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Left ventricular (LV) function is characterized by contraction in the longitudinal, radial, and circumferential planes. Previous studies of postexercise changes in LV function have assessed global indices of LV function. The purpose of this study was to use 2-dimensional (2D) strain analysis to examine LV function following marathon running in the circumferential, radial, and longitudinal planes, and to compare these data with other global and regional indices of function. Fifteen (mean ± SD: age, 32 ± 7 years; stature, 1.76 ± 0.08 m; body mass, 77.8 ± 8.2 kg) competitors in the London Maratho

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Sartor, Carolyn I., Bercedis L. Peterson, Susan Woolf, et al. "Effect of Addition of Adjuvant Paclitaxel on Radiotherapy Delivery and Locoregional Control of Node-Positive Breast Cancer: Cancer and Leukemia Group B 9344." Journal of Clinical Oncology 23, no. 1 (2005): 30–40. http://dx.doi.org/10.1200/jco.2005.12.044.

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Purpose We compared radiotherapy (RT) delivery and locoregional control in patients with node-positive breast cancer randomly assigned on Cancer and Leukemia Group B 9344 to receive adjuvant doxorubicin/cyclophosphamide (AC) with patients assigned to receive AC followed by paclitaxel (AC+T). Methods Eligible patients were randomly assigned to receive adjuvant AC versus AC+T chemotherapy. RT was required if breast-conserving surgery was performed but was elective after mastectomy. Information about RT delivery was retrospectively collected. Cumulative incidence of locoregional recurrence (LRR),

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Cohen, Omer, Hifa Kanana, Ronen Zoizner, et al. "Altered Ca2+ handling and myofilament desensitization underlie cardiomyocyte performance in normothermic and hyperthermic heat-acclimated rat hearts." Journal of Applied Physiology 103, no. 1 (2007): 266–75. http://dx.doi.org/10.1152/japplphysiol.01351.2006.

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Heat acclimation (AC) improves cardiac mechanical and metabolic performance. Using cardiomyocytes and isolated hearts from 30-day and 2-day acclimated rats (AC and AC-2d, 34°C), we characterized cellular contractile mechanisms under normothermic (37°C) and hyperthermic (39–42°C) conditions. To determine contractile responses, Ca2+ transients (Ca2+ T), sarcoplasmic reticulum (SR) Ca2+ pool size (fura-2/indo-1 fluorescence), force generation [amplitude systolic motion (ASM)], L-type Ca2+ channels [dihydropyridine receptor (DHPR)], ryanodine receptors (RyRs), and total (PLBt) and phosphorylated p

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Jimenez-Martinez, Maria C., Miguel Alonso, Iris Estrada-Garcia I, Sergio Estrada-Parra, Mayra Perez-Tapia та Yonathan Garfias. "CXCL9 and γδ T cells are increased in patients with allergic conjunctivitis (P3159)". Journal of Immunology 190, № 1_Supplement (2013): 43.41. http://dx.doi.org/10.4049/jimmunol.190.supp.43.41.

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Abstract Allergic conjunctivitis (AC) is a frequent disease that affects the ocular surface, The study of immune physiopathology of allergic conjunctivitis is focused on T helper cells. Recently it has been suggested that γδ T lymphocytes are necessary for the maintenance of the ocular allergic response, however there are not studies in humans about the role of γδ T lymphocytes in human AC. The aim of this study was to evaluate the frequency of γδ T cells and chemokines in tears of AC patients. Patients: 31 patients were included (16 men and 15 women), AC diagnosis was based on clinical histor

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Huet, S., H. Wakasugi, G. Sterkers, et al. "T cell activation via CD2 [T, gp50]: the role of accessory cells in activating resting T cells via CD2." Journal of Immunology 137, no. 5 (1986): 1420–28. http://dx.doi.org/10.4049/jimmunol.137.5.1420.

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Abstract Monoclonal antibody (MAb) GT2 defines a unique epitope on the CD2 molecule. GT2 triggers T cell mitosis in combination with any MAb directed against 9.6/T11(1) or D66, two previously defined CD2 epitopes. We have shown already that accessory cells (AC) are required for plenary T-PBL activation by any pair of Ab directed against D66 + 9.6/T11(1). In this study, we further investigated their role and found it to vary with the anti-CD2 pair used. When purified T-PBL preparation is used, the level of [3H]TdR incorporation observed with anti-(GT2 + 9.6/T11(1)) Ab was not significant; howev

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Wang, Ruifang, Kexin Zong, Juan Song, et al. "Inhibitor of CD147 Suppresses T Cell Activation and Recruitment in CVB3-Induced Acute Viral Myocarditis." Viruses 15, no. 5 (2023): 1137. http://dx.doi.org/10.3390/v15051137.

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Viral myocarditis (VMC) is a common disease characterized by cardiac inflammation. AC-73, an inhibitor of CD147, disrupts the dimerization of CD147, which participates in the regulation of inflammation. To explore whether AC-73 could alleviate cardiac inflammation induced by CVB3, mice were injected intraperitoneally with AC-73 on the fourth day post-infection (dpi) and sacrificed on the seventh dpi. Pathological changes in the myocardium, T cell activation or differentiation, and expression of cytokines were analyzed using H&E staining, flow cytometry, fluorescence staining and multiplex

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MATHEW, Sunil T., Nehal D. PATEL, and Binod K. SINGH. "T-wave alternans." Acta Cardiologica 60, no. 6 (2005): 639–49. http://dx.doi.org/10.2143/ac.60.6.2004937.

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V. Michiels, M. Claeys, and C. Vrints. "Hyperacute T-waves." Acta Cardiologica 64, no. 4 (2009): 555. http://dx.doi.org/10.2143/ac.64.4.2041624.

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Abusief, M. E., S. A. Missmer, E. S. Ginsburg, J. C. Weeks, E. P. Winer, and A. H. Partridge. "Chemotherapy-related amenorrhea in women with early breast cancer: The effect of paclitaxel or dose density." Journal of Clinical Oncology 24, no. 18_suppl (2006): 10506. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.10506.

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10506 Background: The effect of the addition of paclitaxel (T) to adriamycin and cyclophosphamide (AC), or dose density (DD, q2wk) on menstrual functioning in women with early breast cancer remains uncertain. Methods: We reviewed data from premenopausal women treated at Dana-Farber Cancer Institute and Brigham and Women’s Hospital who received adjuvant chemotherapy with either AC or AC-T from 1997–2005 for whom pre- and post-treatment menstrual data were available. A multivariable logistic regression model evaluating amenorrhea at 6 months or greater follow-up was conducted. Results: Of the 40

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Duan, Shouhui, Bixuan Fan, and Zhenglu Duan. "Geometric Stochastic Resonance in an Asymmetric T-Shaped Chamber." Symmetry 15, no. 12 (2023): 2183. http://dx.doi.org/10.3390/sym15122183.

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The investigation of a Brownian particle subjected to an AC force that diffuses within a T-shaped chamber was conducted. This T-shaped chamber is composed of a strip cavity and a trapezoidal cavity positioned below it. The interplay between the AC force and asymmetric geometry creates a spatially bistable potential perpendicular to the AC force. With the assistance of noise, the particles can transition between two stable states and oscillate along the AC force at corresponding amplitudes at every spatially stable state. The asymmetric geometry facilitates the trapezoid cavity’s ability to mor

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Rastogi, P., J. Jeong, C. E. Geyer, et al. "Five year update of cardiac dysfunction on NSABP B-31, a randomized trial of sequential doxorubicin/cyclophosphamide (AC)→paclitaxel (T) vs. AC→T with trastuzumab (H)." Journal of Clinical Oncology 25, no. 18_suppl (2007): LBA513. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.lba513.

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LBA513 Background: Trastuzumab (H) has been shown to improve survival in HER2 positive, node-positive breast cancer patients when combined with paclitaxel following AC (Romond NEJM 2005:353;1673–1684). Cardiac dysfunction is the major toxicity associated with this regimen. Methods: NSABP B-31 compared doxorubicin and cyclophosphamide (AC) followed by paclitaxel with AC followed by paclitaxel plus 52 weeks of trastuzumab beginning concurrently with paclitaxel in patients with node- positive, HER2-positive breast cancer. Initiation of trastuzumab required normal post-AC left ventricular ejection

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Tesch, Megan, Nathalie LeVasseur, Christine E. Simmons, and Stephen K. L. Chia. "Impact of sequence order of anthracyclines and taxanes in neoadjuvant chemotherapy for breast cancer: Results from a prospective institutional database." Journal of Clinical Oncology 38, no. 15_suppl (2020): e12619-e12619. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e12619.

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e12619 Background: There has been growing interest in the optimal sequencing of anthracyclines and taxanes in neoadjuvant chemotherapy (NACT) for breast cancer. However, data comparing efficacy of administering taxanes prior to anthracyclines as opposed to the opposite sequence remains limited and inconsistent. The objective of our study was to assess the impact of sequence order on pathologic and clinical outcomes in a real-world setting. Methods: A prospective institutional database was analyzed to identify all HER2-negative breast cancer patients treated with NACT from 2012 to 2019. Rates o

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Jenkins, E. O., A. M. Deal, E. Burrows, A. Drobish, and L. A. Carey. "Improved clinical response from neoadjuvant taxane chemotherapy across breast cancer subtypes." Journal of Clinical Oncology 27, no. 15_suppl (2009): 576. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.576.

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576 Background: Adjuvant trials suggest that taxane (T) after doxorubicin and cyclophosphamide (AC) has little benefit in hormone receptor positive (HR+) patients compared to hormone receptor negative (HR-) patients, particularly if HER2 negative. Primary chemotherapy sensitivity is best determined from the neoadjuvant setting, therefore we sought to determine if HR+ primary tumors are less sensitive to taxane chemotherapy than HR- tumors. Methods: Clinical stage II-III breast cancer patients from the UNC Neoadjuvant Database who received sequential AC and T chemotherapy were evaluated. Clinic

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Barcenas, Carlos H., Jiangong Niu, Ning Zhang, et al. "Risk of Hospitalization According to Chemotherapy Regimen in Early-Stage Breast Cancer." Journal of Clinical Oncology 32, no. 19 (2014): 2010–17. http://dx.doi.org/10.1200/jco.2013.49.3676.

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PurposeTo compare the risk of hospitalization between patients with early-stage breast cancer who received different chemotherapy regimens.Patient and MethodsWe identified 3,567 patients older than age 65 years from the SEER/Texas Cancer Registry-Medicare database and 9,327 patients younger than age 65 years from the MarketScan database who were diagnosed with early-stage breast cancer between 2003 and 2007. The selection was nonrandomized and nonprospectively collected. We categorized patients according to the regimens they received: docetaxel (T) and cyclophosphamide (C), doxorubicin (A) and

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Geyer, C. E., J. L. Bryant, E. H. Romond, et al. "Update of cardiac dysfunction on NSABP B-31, a randomized trial of sequential doxorubicin/cyclophosphamide (AC)→paclitaxel (T) vs. AC→T with trastuzumab (H)." Journal of Clinical Oncology 24, no. 18_suppl (2006): 581. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.581.

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581 Trastuzumab (H) has been shown to improve 3-year disease-free survival (DFS) and overall survival (OS) in HER2 positive, node-positive breast cancer patients when combined with paclitaxel (T) following AC (Romond NEJM 2005:353;1673–1684). Cardiac dysfunction is the major toxicity associated with the addition of H to AC→T. The 3-year cumulative incidence of cardiac events (class III/IV CHF or cardiac death) with AC→TH was 4.1% compared to 0.8% with AC→T (Tan-Chiu JCO 2005:23;7811–7819). An updated analysis of cardiac safety on B-31 with an additional full year of follow-up is planned for Ma

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Malek, T. R., C. Chan, L. H. Glimcher, R. N. Germain, and E. M. Shevach. "Influence of accessory cell and T cell surface antigens on mitogen-induced IL 2 receptor expression." Journal of Immunology 135, no. 3 (1985): 1826–33. http://dx.doi.org/10.4049/jimmunol.135.3.1826.

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Abstract We have assessed the inhibitory effects of various monoclonal antibodies on the expression of the IL 2 receptor. Anti-LFA-1, but not anti-Ly-2, markedly inhibited the induction of the IL 2 receptor on the Ly-2+ subset. T-depleted spleen cells, L cells, and B lymphoma cells all functioned as potent accessory cells (AC) for the induction of the IL 2 receptor on L3T4+ T cells. Anti-LFA-1 inhibited the induction of the IL 2 receptor irrespective of the type of AC used. Anti-L3T4 only inhibited the induction of IL 2 receptor expression when L cells were the source of AC. The inhibitory cap

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Ahn, J., S. Kim, B. Son, S. Ahn, and W. Kim. "Adjuvant CAF versus AC followed by paclitaxel for operable breast cancer with 4 or more involved axillary lymph nodes: Retrospective analysis." Journal of Clinical Oncology 24, no. 18_suppl (2006): 10610. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.10610.

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10610 Background: Recently, adjuvant AC followed by paclitaxel has improved disease-free survival (DFS) or overall survival (OS) of node-positive breast cancer. Although adjuvant TAC, as compared with FAC, significantly improves DFS and OS rate in node-positive breast cancer, AC→T has not been yet compared with FAC. Since 2001, we discussed the options of adjuvant CAF versus AC→T with patients who had 4 or more positive axillary nodes. We evaluated the efficacies of adjuvant CAF and AC→T, retrospectively. Methods: Between September 2001 and July 2004, a total of 1,394 patients underwent surger

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Stewart-Akers, AM, JS Cairns, DJ Tweardy, and SA McCarthy. "Granulocyte-macrophage colony-stimulating factor augmentation of T-cell receptor-dependent and T-cell receptor-independent thymocyte proliferation." Blood 83, no. 3 (1994): 713–23. http://dx.doi.org/10.1182/blood.v83.3.713.713.

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Abstract The effects of granulocyte-macrophage colony-stimulating factor (GM- CSF) are not confined to cells of the myeloid lineage. GM-CSF has been shown to have effects on mature T cells and both mature and immature T- cell lines. We therefore examined the GM-CSF responsiveness of murine thymocytes to investigate whether GM-CSF also affected normal immature T lymphocytes. The studies presented here indicate that GM-CSF augments accessory cell (AC)-dependent T-cell receptor (TCR)-mediated proliferation of unseparated thymocyte populations. To identify the GM- CSF responsive cell type, thymic

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Stewart-Akers, AM, JS Cairns, DJ Tweardy, and SA McCarthy. "Granulocyte-macrophage colony-stimulating factor augmentation of T-cell receptor-dependent and T-cell receptor-independent thymocyte proliferation." Blood 83, no. 3 (1994): 713–23. http://dx.doi.org/10.1182/blood.v83.3.713.bloodjournal833713.

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The effects of granulocyte-macrophage colony-stimulating factor (GM- CSF) are not confined to cells of the myeloid lineage. GM-CSF has been shown to have effects on mature T cells and both mature and immature T- cell lines. We therefore examined the GM-CSF responsiveness of murine thymocytes to investigate whether GM-CSF also affected normal immature T lymphocytes. The studies presented here indicate that GM-CSF augments accessory cell (AC)-dependent T-cell receptor (TCR)-mediated proliferation of unseparated thymocyte populations. To identify the GM- CSF responsive cell type, thymic AC and T

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XINGLIN, ZENG, CAO LIEZHAO, and ZHANG YUHENG. "ANALYTIC RELATION BETWEEN THE PEAK TEMPERATURE OF THE IMAGINARY PART OF THE ac SUSCEPTIBILITY OF A SUPERCONDUCTOR AND THE APPLIED dc MAGNETIC FIELD." Modern Physics Letters B 06, no. 06 (1992): 335–41. http://dx.doi.org/10.1142/s0217984992000417.

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The critical state model is employed to calculate the real (χ′) and imaginary parts (χ″) of ac susceptibility of a homogeneous superconducting slab (or a cylinder) under the conditions of ac magnetic field amplitude H ac ≪H dc (superimposed dc magnetic field) and low frequency. The calculated results are analytic and a relation (4π/c)J c (T p , H dc )d= (3/4) H ac between the χ″-peak temperature (T p ) and H dc is obtained. The theoretical prediction for χ′-χ″ curve is consistent with our experimental data, and the experimental power law [Formula: see text] in high-T c superconductors was expl

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Hathcock, K. S., D. M. Segal, and R. J. Hodes. "Activation of Lyt-2+ (CD8+) and L3T4+ (CD4+) T cell subsets by anti-receptor antibody." Journal of Immunology 142, no. 7 (1989): 2181–86. http://dx.doi.org/10.4049/jimmunol.142.7.2181.

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Abstract The mAb F23.1, specific for V beta 8-related determinants on the TCR, was used to study the requirements for TCR cross-linking and for accessory cells (AC) in the induction of proliferation or IL-2 responsiveness in L3T4+ (CD4+) and Lyt-2+ (CD8+) T cells. T cells were exposed in vitro to soluble native F23.1 antibody, to heteroconjugates composed of the Fab fragments of F23.1 linked to Fab fragments of antibodies specific for Ia determinants on AC, or to F23.1 immobilized on an insoluble matrix. Soluble F23.1 antibody-induced proliferation in naive T cells only in the presence of both

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ZHANG, GUANG-SHI, SHU WEN LI, and FUN SUN CHU. "Production and Characterization of Antibody Against Deoxynivalenol Triacetate." Journal of Food Protection 49, no. 5 (1986): 336–39. http://dx.doi.org/10.4315/0362-028x-49.5.336.

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Antibodies against deoxynivalenol-triacetate (Tri-Ac-DON) was prepared by immunizing rabbits with a hemisuccinate derivative of 7,8 dihydroxycalonectrin (DHC) conjugated to bovine serum albumin. Using tritiated Tri-Ac-DON as the testing ligand, antibody titers were observed as early as 4 wk after immunization. Useful antibody for radioimmunoassay (RIA) of Tri-Ac-DON was obtained from the rabbits 7 wk after immunization, with one booster injection. Competitive RIA revealed that the antibody was most specific for Tri-Ac-DON. The relative cross-reactivity of this antibody with Tri-Ac-DON, T-2 tox

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Davis, L., R. Vida, and P. E. Lipsky. "Regulation of human T lymphocyte mitogenesis by antibodies to CD3." Journal of Immunology 137, no. 12 (1986): 3758–67. http://dx.doi.org/10.4049/jimmunol.137.12.3758.

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Abstract The inhibitory and mitogenic effects of anti-CD3 antibodies (anti-CD3) were examined in cultures of human peripheral blood T cells. Resting T cells required the presence of accessory cells (AC) or phorbol myristate acetate (PMA) to be stimulated by soluble anti-CD3 (OKT3 and 64.1). Anti-CD3 was unable to induce activation of AC-depleted T cells as determined by IL 2 receptor expression, IL 2 production, cell cycle analysis, or detectable DNA synthesis. Although T cell responses to PHA also required AC, far fewer were necessary to generate responses. Anti-CD3 inhibited PHA-stimulated T

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Gadisa, Diriba Alemayehu, Mathewos Assefa, Shu-Hua Wang, and Getnet Yimer. "Toxicity profile of Doxorubicin-Cyclophosphamide and Doxorubicin-Cyclophosphamide followed by Paclitaxel regimen and its associated factors among women with breast cancer in Ethiopia: A prospective cohort study." Journal of Oncology Pharmacy Practice 26, no. 8 (2020): 1912–20. http://dx.doi.org/10.1177/1078155220907658.

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Background Management of patients with breast cancer undergoing chemotherapy is complicated by a very high rate of adverse drug reactions which is even more challenging in developing countries like Ethiopia where the toxicity profile of chemotherapy is lacking. The present study aimed at evaluating the toxicity profile of Doxorubicin-Cyclophosphamide (AC) and Doxorubicin-Cyclophosphamide→Paclitaxel (AC→T) regimens among 146 patients with breast cancer in Ethiopia. Methods This prospective cohort study, with the median of six months’ follow-up, was conducted from January 1 to September 30, 2017

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