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1
Kyrri, Andreani R. "Molecular epidemiology of and B globin variants in Cyprus." Thesis, University of London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441412.
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Lavin, Dominic. "Branching fraction measurements of the rare B decays B°→K*⁺s⁻ and B°→K*⁰s⁰." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/11832.
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Dvoretskii, Alexei Hitlin David. "Dalitz plot analysis of the decay B+ -> K+K+K- /." Diss., Pasadena, Calif. : Caltech, 2006. http://resolver.caltech.edu/CaltechETD:etd-03312006-135838.
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Pounder, Nicola. "Measurement of the B⁰ [s arrow] K⁺K ̄decays." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504455.
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Mitsigkas, Neophytos. "Using novels in English language teaching in Cyprus." Thesis, University of Essex, 2016. http://repository.essex.ac.uk/19316/.
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This thesis reports on a mixed-methods descriptive study concerning the students and teachers’ perceptions of the role of literature – and novels in particular – in English language teaching and learning. Literature has always been a perpetual feature of language learning, and the transition from the aesthetic study of literature to its use as a resource for linguistic development in the language classroom has marked its implementation and use. For many decades, the use of literature for language teaching was marginalised because of the advent of communicative language teaching. Nevertheless, the current trend favours a resurgence of interest in using literature for language purposes, appreciating its valuable contribution in English language teaching. However, very limited empirical research has been done to examine the use of novels in language teaching. The quantitative component of this research involved 144 students of an English-speaking private school in Cyprus and 26 English language teachers. Both groups responded to a distinct self-completed questionnaire. A follow-up qualitative investigation was carried out with five of the teachers who completed the questionnaire. Lastly, twelve unstructured, non-participant observations were organised with the students who completed the questionnaire, in their classrooms. For a statistical analysis, IBM SPSS Statistics 19 was used, while the qualitative data analysis was done with NVivo 10 and the results from the quantitative and qualitative enquiry were then integrated in order to respond to six research questions. The findings of the study present the students and teachers’ beliefs on the role of novels in ELT and elucidate the acceptance of novels as an invaluable source of motivating and stimulating activities that can contribute to the increase of students’ language awareness. Additionally, the findings resulting from an examination of the students and teachers’ beliefs substantiate and promote the catalytic role of novels in developing an intercultural awareness, where language and culture are seen as interrelated entities and novels are perceived as vivid cultural representations.
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Hardy, Samuel Andrew. "Interrogating archaeological ethics in conflict zones : cultural heritage work in cyprus." Thesis, University of Sussex, 2010. http://sro.sussex.ac.uk/id/eprint/7344/.
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Much affected by viewing the Yugoslav Wars' ruins, I resolved to study archaeology in conflict. I wanted to explore archaeology's role in conflict and archaeologists' responsibilities in conflict zones; but unable to conduct such work in Kosova/Kosovo, I went to Cyprus. Drawing together professional documentation and public education, professional and community interactions and interviews, and cultural heritage site visits, I researched the destruction of community places, the looting of cultural heritage, and the coping strategies of archaeologists. The key questions of this thesis are: is it legal and ethical to conduct archaeological work in occupied and secessionist territories? How is public knowledge of cultural heritage looting and destruction constructed? What are cultural heritage professionals' responsibilities for knowledge production during conflict? How ought cultural heritage professionals to combat the looting and illicit trading of antiquities? I have addressed these questions by concentrating upon cultural heritage workers' narratives of looting and destruction from 1955 until the present in professional discussion and mass education. First, I argue that archaeologists have misinterpreted international law, and through boycotting and blacklisting of rescue archaeology in northern Cyprus, harmed both the profession and the cultural heritage. Second, I argue that cultural heritage workers have been unwillingly coopted, or actively complicit in the conflict, in the production of nationalist histories, and thus nationalist communities, therefore in the reproduction of nationalist conflict. Third, I argue that cultural heritage workers have knowingly contributed to the conflict and its destruction, through their nationalist policies on the paramilitary-dominated illicit antiquities trade. My conclusions are: that an ethical antiquities policy would cut funding to and thereby reduce conflict-fuelling extremist activity; and that, where they have the freedom to practice it, professional and ethical archaeologies of destruction would promote intracommunal and intercommunal peace.
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Gabyshev, N., K. Abe, K. Abe, I. Adachi, H. Aihara, Y. Asano, V. Aulchenko, et al. "Observation of B^+ → Λ^+_c Λ^－_c K^+ and B^0 → Λ^+_c Λ^－_c K^0 Decays." American Physical Society, 2006. http://hdl.handle.net/2237/8855.
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Déléage, Nicolas. "Étude des désintégrations B⁰(s)→D̅⁰K⁺K⁻ et des sous-modes B⁰(s)→D̅⁽*⁾⁰φ avec le détecteur LHCb." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAY073.
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L'expérience LHCb a été conçue pour étudier la physique des saveurs, dont entre autre la violation de CP, sur le collisioneur proton-proton LHC. La première phase de fonctionnement du LHC a durée de 2011 à 2012, ce qui a permis à LHCb de collecter 3.19~fb⁻¹ de données à une énergie dans le centre de masse des collisions de √s = 7~TeV et √s = 8~TeV. L'analyse présentée dans cette thèse est basée sur l'ensemble des données collectées par LHCb lors de la première phase de fonctionnement (2011-2012).Le mécanisme de Cabibbo-Kobayashi-Maskawa (CKM) est le mécanisme décrivant la violation de CP dans le cadre du Modèle Standard.Les expériences de la décennie précédente, dédiées à la physique des saveurs, BaBar et Belle, ont permis de démontrer le fonctionnement du mécanisme CKM et de démontrer qu'il est majoritairement Standard.`A présent LHCb a pour objectif de mesurer avec précision les paramètres de ce mécanisme, ce qui constitue des points de références du Modèle Standard, pour en parallèle rechercher de manière indirecte de la Nouvelle Physique en recherchant des déviations à ces points de références du Modèle Standard.Les travaux réalisés lors de cette thèse s'inscrivent dans le cadre du premier axe de recherche: réaliser des mesures de précision des paramètres du mécanisme CKM pour contraindre le Modèle Standard. Dans cette thèse nous réalisons la mesure la plus précise à l'heure actuelle du rapport d'embranchement de la désintégration B⁰(s)→D̅⁰K⁺K⁻, la première observation des modes B⁰(s)→D̅⁰K⁺K⁻ et B⁰(s)→D̅⁽*⁾⁰φ avec mesure de la polarisation de ce dernier, la confirmation de la mesure du rapport d'embranchement de la désintégration B⁰(s)→D̅⁽*⁾⁰φ, ainsi que des limites supérieures sur le rapport d'embranchement de la désintégration B⁰(s)→D̅⁽*⁾⁰φ et sur l'angle de mélange des mésons {ω - φ}. L'observation de ces modes B⁰(s)→D̅⁰K⁺K⁻ et sous modes B⁰(s)→D̅⁽*⁾⁰φ permet de préparer les futures analyses de Dalitz de ces modes qui contribueront, en les combinant avec les autres méthodes, à améliorer la précision sur la mesure de la phase complexe γ du mécanisme CKMThe LHCb experiment has been designed to study flavor physics, notably CP violation, on the LHC proton-proton collider. The first LHC run goes from 2011 to 2012, during what LHCb saved 3.19~fb⁻¹ of data with a collision centre-of-mass energy at √s = 7~TeV and √s = 8~TeV.The analysis presented in this thesis is based on a data sample corresponding to the full first run of the LHC (2011-2012). The Cabibbo-Kobayashi-Maskawa (CKM) mechanism describes CP violation in the Standard Model.In the previous decade, two dedicated experiments to flavor physics, BaBar and Belle, proved that the CKM mechanism is at work and dominated by Standard effects.Now LHCb aim is to improve precision on measurements of CKM parameters, in order to serves as the Standard Model reference points, to make in parallel indirect search of New Physics looking for deviations from the Standard Model reference points.Accurate measurements of CKM parameters through different processes provide sensitivity to new physics effects, by testing the global consistency of the Standard Model. This thesis is included inside the first LHCb aim: to improve CKM parameters measurements to constrain the Standard Model.This thesis reports the most precise measurement to date of the branching fraction of B⁰(s)→D̅⁰K⁺K⁻ decay, the first observation of the decays B⁰(s)→D̅⁰K⁺K⁻ and B⁰(s)→D̅⁽*⁾⁰φ with a polarization measurement for the second one, confirmation of the branching fraction measurement of B⁰(s)→D̅⁽*⁾⁰φ, and upper limits on branching fraction of B⁰(s)→D̅⁽*⁾⁰φ decay and on {ω - φ} mixing angle. The observation of B⁰(s)→D̅⁰K⁺K⁻ and B⁰(s)→D̅⁽*⁾⁰φ decays prepare the Dalitz analysis for these channels which will be used, combined with other methodes, to improve measurement on the γ complex-phase of the CKM mechanism
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Ewerth, Thorsten. "Rare K- and B-decays in the MSSM." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973069376.
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Ewing, Alistair Kyles. "Lattice calculations in the B and K systems." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241142.
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Cliff, Harry Victor. "A measurement of the B⁰s -> K⁺K⁻ lifetime at the LHCb experiment." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610085.
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Bharucha, Aoife Katy Manek. "B → K∗µ+µ− and form factors for semi-leptonic and radiative B decays." Thesis, Durham University, 2010. http://etheses.dur.ac.uk/486/.
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The hadronic environment of the LHC favours the study of exclusive modes, and of these semi-leptonic and radiative B decays will play a leading role in the search for new physics (NP). A prime example is the rare decay B→K∗(→ Kπ)µ+µ−, where the many measurable quantities offer important new tests of the Standard Model and its extensions. We define sets of CP-conserving and CP-violating observables which are studied in terms of the full form factors, calculated in QCD sum rules on the light-cone (LCSR), and QCD factorisation. Those with reduced dependence on hadronic quantities and sensitivity to NP are identified. In the first few years of data–taking at the LHC, the focus will be on quantities which are simple to extract while maximising the available NP sensitivity. Out of three such observables, two are well known to the experimental community. However a third, one of the CP-conserving angular observables, leads to significant additional constraints on parameter space. We then study form factors for rare semi-leptonic and radiative B decays to K(∗) , ρ and φs mesons, combining theoretical and phenomenological constraints from Lattice QCD, LCSR, and dispersive bounds. We pay particular attention to form factor parameterisations which are based on the so-called series expansion, and study the related systematic uncertainties on a quantitative level. Finally we calculate the leading-twist O(αsβ0) corrections to the B → π transition form factor f+ (0) in LCSR, allowing an improved determination of the CKM matrix element |Vub |.
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Hadavand, Haleh K. "The measurement of CP asymmetries in the three-body charmless decay B⁰ --> K⁰s K⁰s K⁰s." Diss., Connected to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3187821.
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Thesis (Ph. D.)--University of California, San Diego, 2005.Title from first page of PDF file (viewed January 11, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 149-151).
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Mello, Érik Luca de. "Ultradarwinismo em K. R. Popper e B. F. Skinner." Universidade Federal de São Carlos, 2013. https://repositorio.ufscar.br/handle/ufscar/5987.
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The theory of natural selection as one of the causal processes of Darwin s theory of evolution has impacted on fields of knowledge far beyond natural sciences. This extension the employment of the logic of selection in psychology and philosophy, as can be found in Popper and Skinner is usually defined as ultra-Darwinism. Darwin s ideas and their impact following the publication of The Origin of Species were approached through Ernst Mayr interpretation. The objectives of this study were: (1) to show Darwin s influence on the works of Popper and Skinner; and (2) to present a brief comparison between Popper and Skinner s points of view concerning with the fate of societies. The method employed was an aporetic one. The main results were: (1) The logic of selection makes it possible to find common epistemological features in the works of Popper and Skinner; (2) both authors hold that scientific knowledge is a means for the investigation of culture and cultural planning; (3) both authors agree that essentialistic theoretical beliefs are an obstacle for technological advances and cause of delay in the development of civilization; (4) they are contemporary with events of worldwide impact brought about by mankind throughout the twentieth century that had a great impact on their works.
A teoria da seleção natural como um dos processos causais da teoria da evolução de Darwin atingiu áreas de conhecimento bem além das ciências naturais. Essa expansão o emprego da lógica selecionista na psicologia e na filosofia, que encontramos em autores como Popper e Skinner é o que usualmente se define como ultradarwinismo. As idéias de Darwin, assim como seus efeitos após a publicação de A Origem das Espécies, foram abordadas a partir da interpretação fornecida por Ernst Mayr. O presente trabalho teve como objetivos: (1) Demonstrar a influência do autor inglês nos textos de Popper e Skinner, e (2) Apresentar breves comparações do que produziu Popper com a visão de Skinner como autores preocupados com o destino das sociedades. O método utilizado foi o aporético. Os principais resultados encontrados foram: (1) a lógica selecionista permite evidenciar elementos epistemológicos comuns nos trabalhos de Popper e de Skinner; (2) ambos os autores apontam o conhecimento científico como via de investigação e planejamento cultural; (3) ambos entendem que posições teóricas essencialistas funcionam como obstáculo para o avanço tecnológico e como causa de atraso no desenvolvimento das civilizações; (4) eles são contemporâneos de eventos de impacto mundial promovidos pelo homem no séc. XX, os quais influenciaram as teorias produzidas por ambos.
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Zwahlen, Nicolas. "Study of the B --> X(3872)K --> D*°⁻D°K decay at Belle /." Lausanne : EPFL, 2009. http://library.epfl.ch/theses/?nr=4321.
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Thèse Ecole polytechnique fédérale de Lausanne EPFL, no 4321 (2009), Faculté des sciences de base SB, Programme doctoral Physique, Institut de physique de l'énergie et des particules IPEP (Laboratoire de physique des hautes énergies 2 LPHE2). Dir.: Olivier Schneider, Thomas Schietinger.
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Skidmore, Nicola Anne. "Amplitude analysis of D⁰→K⁺K⁻π⁺π⁻ and its subsequent use in measuring the CKM phase γ through B±→D(→K⁺K⁻π⁺π⁻)K± decays at LHCb." Thesis, University of Bristol, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730895.
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Colberg, Tilmann. "Measurement of the branching fraction and search for direct CP violation in the radiative decay B->K*c [B K gamma] with the BABAR detector." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964612704.
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Hussain, Nazim. "A study of CP violation in B±→Dh±(h=K,π) with the modes D→K±π±π⁰, D→π+π-π⁰ and D→K+K-π⁰." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:355e8272-ee39-4124-a4cc-6351daa3ff2c.
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One of the objectives of the LHCb experiment at CERN is a precision determination of the angle γ from the CKM Unitarity Triangle, a CP-violating parameter of the Standard Model. Sensitivity to γ can be obtained by exploiting the interference effects in B±→Dh± (h=K,π) decays, which can lead to measurable charge asymmetries. The results are interpreted in the context of γ and related parameters.
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Zhou, Jiang-Feng 1964. "PCR tests for the A- and B-alleles of k-casein and b-lactoglobulin in Holstein cattle." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56817.
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Methodologies have been devised to genotype the $ kappa$-casein ($ kappa$-CN) and $ beta$-lactoglobulin ($ beta$-LG) loci using the polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLPs) analysis. A fragment of 432 base pair from the $ kappa$-CN gene which contains the nucleotide substitutions diagnostic of the A- and B-alleles of $ kappa$-CN was amplified. DNA amplified from the A-variant contained a unique HinfI restriction site, whereas DNA amplified from the B-variant contained a unique TaqI site. Thus, the genotype of the animal could be determined by restriction enzyme analysis. A region extending from exon IV to V of the $ beta$-LG gene was also amplified using PCR. In this region, the B-allele contains 2 HaeIII restriction sites which are not present in DNA amplified from the A-allele. The digestion of the PCR product with HaeIII thus allowed discrimination between the A- and B-alleles. Analysis of bulls (n = 68) used by artificial insemination (AI) centres after 1980, bulls (n = 27) used before 1960, a random sample of male calves (n = 102) and cows (n = 123) revealed a frequency of the B allele of $ kappa$-CN as 0.13, 0.37, 0.22 and 0.19 in these populations, respectively. In the populations of bulls (n = 69) used by AI centres after 1980, bulls (n = 27) used before 1960, a random sample of male calves (n = 99), and cows (n = 129), the B-allele of $ beta$-LG was present at frequencies of 0.60, 0.52, 0.67, and 0.65, respectively. Statistical analysis of these data shows the frequency of the B-allele of $ kappa$-CN was significantly higher in sires (n = 27) which were used by the AI centre before 1960 compared to more modern proven sires (n = 68) (P $<$ 0.01).
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Pérez, Pérez Luis Alejandro. "Time-Dependent Amplitude Analysis of B^0->Kspi+pi- decays with the BaBar Experiment and constraints on the CKM matrix using the B->K*pi and B->rho K modes." Phd thesis, Université Paris-Diderot - Paris VII, 2008. http://tel.archives-ouvertes.fr/tel-00379188.
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Une analyse en amplitudes dépendantes du temps des désintégrations $B^0 \to K^0_S\pi^+\pi^-$ est effectuée afin de mesurer les paramètres de violation de CP des modes $f_0(980)K_S^0$ et $\rho^0(770)K_S^0$, ainsi que l'asymétrie directe de CP pour $K^*(892)^\pm\pi^\mp$. Les résultats sont obtenus à partid d'un échantillon de $(383\pm 3)\times10^{6}$ paires $B\bar{B}$, enregistrées par le détecteur \babar\ auprès du collisionneur asymétrique PEPII au SLAC. Deux solutions sont trouvées, avec des figures de mérite équivalentes sur la qualité de l'ajustement. En incluant les incertitudes systématiques et provenant du modèle de Dalitz utilisé, l'intervalle de confiance combiné sur $\beta_{\rm eff}$ dans le mode $f_0(980)K_S^0$ est $18^\circ< \beta_{\rm eff}<76^\circ$ (à $95\%$ C.L.) ; la conservation de CP dans ce mode est exclue à $3.5$ écarts standard. Pour le mode $\rho^0(770)K_S^0$, l'intervalle de confiance combiné est est $-9^\circ< \beta_{\rm eff}<57^\circ$ (à $95\%$ C.L.). Pour le mode $K^*(892)^\pm\pi^\mp$, le paramètre d'asymétrie directe de CP est $A_{\rm CP}=-0.20 \pm 0.10\pm 0.01\pm 0.02$. La mesure de la phase relative entre les amplitudes de désintégration $B^0\to K^*(892)^+\pi^-$ et $\bar{B}^0\to K^*(892)^-\pi^+$ exclut l'intervalle $[-132^\circ : +25^\circ]$ (à $95\%$ C.L.). Les rapports d'embranchement et les asymétries directes de CP sont mesurées pour tous les modes résonants intermédiaires significatifs. Les mesures obtenues dans les modes $\rho^0(770) K^0_S$ et $K^{*\pm}(892)\pi^{\mp}$ sont utilisées comme paramètres d'entrée dans une analyse phénoménologique des désintégrations $B \to K^*\pi$ et $B \to \rho K$, basée uniquement sur la symétrie d'isospin $SU(2)$. L'ajout d'informations extérieures sur la matrice CKM permet de poser des contraintes sur l'espace des paramètres hadroniques. Pour $B \to K^*\pi$, les intervalles obtenus sur les pingouins électrofaibles ne sont que marginalement en accord avec les attentes théoriques. Les contraintes sur la matrice CKM sont dominées par des incertitudes d'origine théorique. Une étude de prospective, utilisant les améliorations attendues sur les mesures de ces modes à LHCb, ou dans les programmes futurs tels que Super-B ou Belle-upgrade, permet d'illustrer le potentiel de physique de cette approche.
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Watson, Jennifer Elizabeth. "Angular analysis of B → K*l^+l^- using the BaBar detector." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/7565.
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The decay B → K*l^+l^-, where the l^+l^- can be e^+e^- or μ^+μ^-, resulting from the b → s flavour changing neutral current decay is highly sensitive to the presence of new physics. The angular observables describing the K* polarisation (FL) and the forward backward asymmetry (AFB) are first measured in two regions of di-lepton mass squared using a dataset of 384 million BB pairs collected by the BaBar detector on the PEP-II rings at SLAC. A second measurement was made in four regions of di-lepton mass squared using a dataset of 468 million BB pairs.
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Wong, Quincy. "Measurement of CP-observables with B⁻ [right arrow] D⁰K*⁻ decays." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1211904559.
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Nicol, Michelle. "Analysis of the rare decay B->K*ee at LHCb." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112354/document.
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Grâce à la grande section efficace de production de paires bb, LHC offre une excellente occasion de faire des études de courants neutres changeant la saveur. Ces transitions sont sensibles aux effets de nouvelle physique. Cette thèse porte sur l'analyse des événements B->K*ee qui permettent de mesurer la fraction de photon avec une polarisation droite et donc de rechercher des signaux de nouvelle physique émis dans la transition b ->s. En effet, dans le Modèle Standard, la polarisation des photons est gauche. La paire e+e, lors que la masse invariante de la paire de leptons est basse, provient d'un photon virtuel et permet donc de sonder la polarisation de celui-ci. Cette mesure se fait grâce à l'étude des distribution angulaires de cette désintégration à quatre corps. Une première étape est la mesure du rapport d'embranchement dans le domaine de masse 30-1000MeV=c2. En effet, cette désintégration n'a jamais été observée dans cette région, y compris auprès des usines a B a cause du très faible rapport d'embranchement. Cette analyse comportant des électrons de basse impulsion transverse est expérimentalement complexe dans un environnement tel que celui du LHC. La mesure est faite relativement au rapport d'embranchement de la désintégration B->J/Psi(ee)K*. En effet, cela permet de s'affranchir de nombreux effets expérimentaux ainsi que de la détermination absolue des efficacités. Le résultat, repose sur les données collectées par LHCb en 2011 et correspondant a une luminosité intégrée de 1 fb-1: B(B->K*ee)30-1000MeV = (3:19+0:75-0:68(stat) +/- 0:21(syst) =/-0.15(PDG)) x10-7 en utilisant la valeur PDG pour le rapport d'embranchement de la désintégration B->J/Psi(ee)K*. La dernière partie de la thèse porte sur des études Monte Carlo qui montrent que la précision sur la fraction de photon avec une polarisation droite que l'on peut espérer obtenir avec l'inclusion des données de 2012 est d'environ 0.1, comparable à la moyenne mondiale obtenue avec des méthodes différentesThe high bb cross section produced by the LHC offers an excellent opportunity for thestudy of flavour changing neutral current B decays, where the effects of new physics can be probed. This thesis presents an analysis of the rare decay B->K*ee which can be used to measure the polarisation of the photon in the b -> s transition. When the dilepton mass is low, the ee pair comes predominantly from a virtual photon, and the polarisation can be accessed via an angular analysis. It is predicted to be predominantly left handed in the Standard Model, and therefore an enhanced right handed amplitude would be a sign of new physics. A first step is to measure the branching fraction in the dilepton mass range, 30 MeV to 1 GeV. This decay has not yet been observed in this region, due to its small branching ratio. The analysis involves electrons with low transverse momentum, and is thus experimentally complex in the hadronic environment at the LHC. The branching ratio is measured relative to that of B->J/Psi(ee)K*, which eliminates both certain experimental effects, and the need to determine absolute effciencies. The result is obtained with an integrated luminosity of 1 fb-1 of pp collisions, collected by LHCb during 2011 and is found to be:B(B->K*ee)30-1000MeV = (3:19+0:75-0:68(stat) +/- 0:21(syst) =/-0.15(PDG) x10-7 when using the PDG value for the B->J/Psi(ee)K* branching ratio. The last part of the thesis presents Monte Carlo studies, showing that with the inclusion of the 2012 data sample, the expected sensitivity on the fraction of right handed polarisation is approximately 0.1, which is comparable with the world average obtained with different methods
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Novotná, Hana. "Exportní strategie firmy B a K systémy s.r.o. na německý trh." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-124626.
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The diploma thesis The Export Strategy of Company B a K systémy s.r.o. to German Market deals with characteristic of the company B a K systémy s.r.o. and its export politics. The aim of this study is to analyse the export strategy of comapany B a K systémy s.r.o. to the german market and to propose measurements which would be effective in this field. The study is based on the basic characteristic of the company and on the analysis of the german market. At the close of this study are proposed also criterias how to evaluate the proposed measurements.
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Simard, Andree Giselle. "The Manuscript Torino J.II.9: A Late Medieval Perspective on Musical Life and Culture at the Court of the Lusignan Kings at Nicosia." University of Akron / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=akron1135006861.
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Černík, Jaroslav. "Kyperská cesta z finanční krize - změna přístupu k bankovní pomoci?" Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-194098.
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The thesis focuses on Cyprus financial crisis which began in 2012 and on reform tools used by Cyprus government under the Economic Adjustment Programme in order to fix consequential fiscal and monetary imbalances in the economy. Thesis provides description of main factors leading Cyprus in the crisis and broadly analyses reform tools under the EAP. Thesis positively valuates government success in implementing EAP reform tools and describes way the program was financed. Macroeconomic indicators such as GDP, inflation, unemployment and external balance are analyzed and strong influence of reform measures mainly on development of unemployment and external balance is highlighted. Cyprus banking crisis is also a first case of using banks bail-in as a tool to fix financial market imbalances. Shortly discussed is role of Cyprus bank crisis in bail-out to bail-in paradigm change and possible influence of bail-in measures on creditors' behavior and stability of financial institutions.
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Oh, Chang-Heon. "A Unified Analysis of the B = 2 System." Diss., Virginia Tech, 1997. http://hdl.handle.net/10919/30380.
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Results are presented for a unified analysis
of the reactions pp -> pp. pid -> pid and
pid -> pp over the center-of-mass energy
interval from pion threshold to
approximately 2.4 GeV. These results for
pid -> pp and pid elastic scattering are
superior to previous VPI analyses of these
reactions. In particular, the overall phase in
pid -> pp has now been determined.
Comparisons and predictions are made with
previous (separate and unified) analyses of
this two-baryon system. Several partial
wave amplitudes show resonance-like
behavior in these reactions.Ph. D.
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Nicol, Michelle. "Analyse de la désintégration rare B->K*ee dans l'expérience LHCb." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00815968.
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Grâce à la grande section efficace de production de paires bb, LHC offre une excellente occasion de faire des études de courants neutres changeant la saveur. Ces transitions sont sensibles aux effets de nouvelle physique. Cette thèse porte sur l'analyse des événements B->K*ee qui permettent de mesurer la fraction de photon avec une polarisation droite et donc de rechercher des signaux de nouvelle physique émis dans la transition b ->s. En effet, dans le Modèle Standard, la polarisation des photons est gauche. La paire e+e-, lors que la masse invariante de la paire de leptons est basse, provient d'un photon virtuel et permet donc de sonder la polarisation de celui-ci. Cette mesure se fait grâce à l'étude des distribution angulaires de cette désintégration à quatre corps. Une première étape est la mesure du rapport d'embranchement dans le domaine de masse 30-1000MeV=c2. En effet, cette désintégration n'a jamais été observée dans cette région, y compris auprès des usines a B a cause du très faible rapport d'embranchement. Cette analyse comportant des électrons de basse impulsion transverse est expérimentalement complexe dans un environnement tel que celui du LHC. La mesure est faite relativement au rapport d'embranchement de la désintégration B->J/Psi(ee)K*. En effet, cela permet de s'affranchir de nombreux effets expérimentaux ainsi que de la détermination absolue des efficacités. Le résultat, repose sur les données collectées par LHCb en 2011 et correspondant a une luminosité intégrée de 1 fb-1: B(B->K*ee)30-1000MeV = (3:19+0:75-0:68(stat) +/- 0:21(syst) =/-0.15(PDG)) x10-7 en utilisant la valeur PDG pour le rapport d'embranchement de la désintégration B->J/Psi(ee)K*. La dernière partie de la thèse porte sur des études Monte Carlo qui montrent que la précision sur la fraction de photon avec une polarisation droite que l'on peut espérer obtenir avec l'inclusion des données de 2012 est d'environ 0.1, comparable à la moyenne mondiale obtenue avec des méthodes différentes.
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Onyema, Ezenwa Chizimako Sunny. "Mechanism for synthesis of K* Arachno-C₂B₇H₁₂· from Arachno-4,5-C₂B₇H₁₃, and fluxional behavior of Nido-4,5-C₂B₆H₁₀." Click here for download, 2006. http://wwwlib.umi.com/cr/villanova/fullcit?p1434394.
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Malclès, Julie. "Etude des désintégrations B± → K±π0et B± → π±π0 avec le détecteur BABAR et contraintes des modes B → ππ, Kπ, KK sur la matrice CKM." Paris 6, 2006. http://www.theses.fr/2006PA066574.
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Ludwig, Nancy [Verfasser], H. B. [Akademischer Betreuer] Deising, K. [Akademischer Betreuer] Pillen, and E. [Akademischer Betreuer] Kothe. "Penetrationskompetenz pflanzenpathogener Pilze / Nancy Ludwig. Betreuer: H. B. Deising ; K. Pillen ; E. Kothe." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2012. http://d-nb.info/1027100228/34.
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Kusatz, B. [Verfasser]. "Mechanismus und Kinetik der (Na,K)-Entmischung in Ge-substituierten Alkalifeldspaeten / B. Kusatz." Karlsruhe : KIT-Bibliothek, 1991. http://d-nb.info/1155474201/34.
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Loudon, Jenifer A. Z. "The Regulation of Labour Associated Genes by Nuclear Factor k B and Progesterone." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520864.
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Bačiulienė, Kristina. "Laikas ir erdvė Marcelijaus Martinaičio poezijos rinkiniuose „Kukučio baladės“ ir „K. B. Įtariamas“." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20140623_183607-78378.
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SANTRAUKA Naujo tipo subjektą Kukutį XX amžiaus septintajame dešimtmetyje į lietuvių lyriką įvedė poetas, eseistas, vertėjas Marcelijus Teodoras Martinaitis (g. 1936). Magistrinio darbo objektas - baladės iš rinkinių „Kukučio baladės ir „K. B. Įtariamas. Tyrimo tikslas - nustatyti Kukučio ir K. B. laiko ir erdvės parametrų panašumus ir skirtumus. Tikslą padės pasiekti uždaviniai: atskleisti, kas yra mitologija, mitas, ryšys su literatūra; išsiaiškinti paradokso sąvoką; aptarti J. Lotmano pasaulėvaizdžio ir teksto sampratą, veidrodiško atspindžio mechanizmo principą; parodyti lyrinio subjekto Kukučio fenomenalumą; nustatyti Kukučio erdvėlaikio parametrus; atskleisti K. B. modernumą; patyrinėti Kukučio ir K. B. personažų vidinį daugiasluoksniškumą; nustatyti K. B. erdvėlaikio pokyčius. Darbe bus naudojami analizės, interpretacijos ir lyginimo, mitopoetinės kritikos metodai, aiškinamasi paradokso sąvoka. Mitų ištakos - religijos. Mituose atsispindi žmonių pasaulėžiūra ir pasaulėjauta. Konstatuojama, kad mitas kito kaip struktūras ir funkcijas palaikantis pasakojimas, konstruojantis grupę ir jos identitetą; kaip egzegetinis šaltinis; kaip mitologinis pasakojimas, neturintis ryšio su kolektyviniu identitetu ir grupės funkcionavimu. Kultūrinė ir socialinė antropologija šiuolaikinį mitą apibūdina klasikiniais metodais ir postmoderniu požiūriu. Postmodernioji mitologija mitą instituciškai legimituoja, jis tampa racionalių diskusų ir bendruomenių kooperacijos dalimi. Laiko pamatiniu... [toliau žr. visą tekstą]SUMMARY New type of subject Kukutis was introduced in lithuanian poetry in XX century 7 decade by the poet, essayist and interpreter Marcelijus Martinaitis (1936). The object of this Master work are ballads of collections “Kukučio baladės and „K. B. Įtariamas. The aim of this research is to determine lines in time and space where Kukutis and K. B. Are developed. This aim will be achieved by the help of these tasks: to reveal what mythology, myth are and their link to literature; to explain definition of paradox; to talk about J. Lotman’s conception of world-view and text, his view to mechanism of secular reflection; to show phenomenon of lyrical subject Kukutis; to define lines of Kukutis’ spacetime; to reveal modernism of K. B.; to research inner multi-layer of Kukutis and K. B.; to determine changes in Kukutis’ spacetime. The subject is be analysed by the help of anglysis, interpretation and comparison, mythopetic critic‘s methods, definition of paradox is be explained. Myths were beginning is religion. They reflect world view of mankind. It is told that myth developed as a story with it‘s structure and functions. It builds up a group and it‘s identity; as mythological story which has no bond with corporate identity and functions of the group. Cultural and social anthropology determines contemporary myth in classical methods and postmodern view. Postmodern mythodology legitimates, it becomes the part of rational discussions and society‘coorporation. In the aspect of... [to full text]
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Coelho, Lucyanna Moura. "Diversidade genética em populações de castanheira-do-brasil (Bertholletia excelsa H. B. K.)." Universidade Federal do Amazonas, 2013. http://tede.ufam.edu.br/handle/tede/2989.
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Previous issue date: 2013-09-02CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
The Brazil nuts (Bertholletia excelsa H.B.K.) is a symbol tree of the Amazon, which provides a great social, ecological and economic development for the region. In the first four months of 2012, total exports of Brazil nuts reached 4,940 tons, generating revenues of US$ 6.5 million, a figure 65.6% higher than in the same period of 2011. Despite high values of production and export of Brazil Nuts, and the extreme importance it has in the economy, studies show that excessive collection in forests jeopardizes the future of the species. It is through the genetic diversity that species are maintained over time, allowing the evolutionary adaptation of the species as a result of environmental changes. The objective of this work was to study the genetic diversity among and within populations of Brazil nuts by AFLP markers. One hundred and fifty subjects were evaluated, two populations from Aruanã Farm, one from Parintins and two from Manaus. The DNA of these individuals was extracted by CTAB method, based on the protocol of Doyle and Doyle (1987), with some adaptations and quantified. In analyzes, we used four primer combinations (E + ATC / M + CCA + E AGC / M + CAT, E + AGC / M + CCA E + ACA / M + CAC) that generated 306 polymorphic bands (93.3%). Genetic differentiation within and among populations was tested by analysis of molecular variance (AMOVA), using the Genes software (Cruz, 2006a). The genetic distances of Jaccard were used in a cluster analysis of UPGMA type (Unweighted Pair-Group Method by Arithmetic Averages), using the Genes program, and bootstrap test was conducted with 5,000 permutations. Results indicated that the presence of genetic divergence is greater within populations (51.88%) than among populations (48.11%). The Fst value was equal to 0.48. Two groups were formed in interpopulational grouping: the first consisted of individuals from Aruanã Carolina, Aruanã Brastor and Manaus IFAM (planted), and the second presented individuals from Parintins and Manaus Airport (natural). AFLP markers were efficient in the characterization of natural populations and cultured Brazil nuts.
A castanheira-do-Brasil (Bertholletia excelsa H.B.K.) é uma das árvores-símbolo da Amazônia, apresentando um grande valor social, ecológico e econômico para a região. Nos quatro primeiros meses de 2012, o volume total das exportações de castanha-do-Brasil atingiu 4.940 toneladas, gerando uma receita de U$S 6,5 milhões, valor 65,6% superior ao observado no mesmo período de 2011. A coleta excessiva em castanhais nas florestas tem se intensificado e compromete o futuro da espécie. A diversidade genética dentro de uma espécie facilita a adaptação evolutiva em decorrência das mudanças ambientais e precisa ser preservada para que sua perpetuação ocorra. O objetivo deste trabalho foi estudar a diversidade e genética entre e dentro de populações de castanheira-do-Brasil por meio de marcadores moleculares AFLP. Foram avaliadas cinco populações no Estado do Amazonas com 30 indivíduos cada, duas populações da Fazenda Aruanã (Aruanã Carolina e Aruanã Brastor), uma de Parintins e duas de Manaus (Manaus IFAM e Manaus Aeroporto). A extração de DNA foi realizada pelo método CTAB, baseado no protocolo de Doyle e Doyle (1987), com adaptações. Foram utilizados quatro combinações de oligonucleotídeos (E+ATC/M+CCA; E+AGC/M+CAT; E+AGC/M+CCA; E+ACA/M+CAC) na genotipagem dos 150 indivíduos e obtidas 306 bandas polimórficas (93,3%). A diferenciação genética dentro e entre populações foi testada pela análise de variância molecular (AMOVA) utilizando o programa Genes. As distâncias genéticas de Jaccard foram utilizadas em uma análise de agrupamento do tipo UPGMA (Unweighted Pair-Group Method by Arithimetic Averages) e o teste de bootstrap foi realizado com 5.000 reamostragens. Os resultados indicaram que a presença de divergência genética é maior dentro de populações (51.88%) do que entre populações (48.11%). O valor de Fst foi igual a 0,48. Dois grupos foram formados no agrupamento interpopulacional: o primeiro constituiu-se de populações oriundas de plantios, Aruanã Carolina, Aruanã Brastor e Manaus IFAM e o segundo de populações naturais, Parintins e Manaus Aeroporto. Os marcadores AFLP foram eficientes na caracterização de populações naturais e cultivadas de castanheira-do-Brasil.
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Oger, Jean-Michel. "Contribution a l'etude chimique d'une lauracee bolivienne aniba canelilla (h. B. K. ) mez." Angers, 1993. http://www.theses.fr/1993ANGE0504.
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Lin, Chi-Jen David. "Flavour changing neutral current processes of B and K mesons from lattice QCD." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/12420.
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Flavour Changing Neutral Current (FCNC) processes are essential for pinning down free parameters in the Standard Model and for probing possible new physics beyond it. In this work, we compute the non-perturbative strong-interaction effects on a collection of FCNC processes using Lattice QCD. Ratios of the relevant matrix elements of Kaon processes are computed for several initial and final meson momenta and for six light-meson masses ranging from approximately 435 MeV to 815 MeV. Fits of these ratios to the mass and recoil behaviours predicted by Chiral Perturbation Theory are then used to extract the relevant bag parameters.
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Blanco, Marcos Luengo. "O papel do fator nuclear Kappa B (NF-k B) na expressão do gene CYBB do sistema NADPH oxidase humano." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308285.
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Orientador: Antonio Condino NetoTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: Neste trabalho, estudou-se o papel funcional de fator nuclear kappa B (NF-?B), sobre a regulação do gene CYBB e, conseqüentemente, a influência que esse fator exerce sobre o desenvolvimento do sistema NADPH oxidase humano. Células mielocíticas da linhagem U937 transformadas com um vetor carregando o gene repressor de, NF-?B (I-?Ba-S32A/ S36A) demonstraram uma redução na liberação de ânion superóxido e uma diminuição nos níveis de expressão do gene CYBB comparado ao grupo controle de células U937 selvagens. Em paralelo, os mesmos parâmetros foram avaliados em linfócitos B de pacientes com Displasia Anidrótica Ectodérmica com Imunodeficiênca (DAE-ID) transformadas com vírus de Epstein-Barr (EBV), (EBV-DAE-ID?B S32I e DAE-ID NEMO/IKK? X420W), e células de um paciente portador de Doença Granulomatosa Crônica (DGC), com mutação ligada ao X (EBV-DGC-X91°). Esses experimentos também mostraram os mesmos efeitos inibidores da atividade NADPH oxidase, assim como a redução dos níveis de expressão do gene CYBB. Os ensaios de EMSA supershift (anti-p50 humano) demonstraram ausência da ligação do complexo protéico à seqüência consenso para NF-?B 5' do gene do CYBB, confirmando o bloqueio da translocação deste fator para o interior do compartimento nuclear das células U937 transformadas e das células EBV-DAE-ID?B S32I e DAE-ID NEMO/IKK? X420W. Diante destes resultados, conclui-se que o NF-?B é necessário para a ativação da expressão do gene CYBB e conseqüentemente para o desenvolvimento do sistema NADPH oxidase de fagócitos humanos.
Abstract: This work investigated the functional role of nuclear factor-? B (NF-?B) in respiratory burst activity and in expression of the human phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase gene CYBB. U937 cells with a stably transfected repressor of NF-?B (I-?Ba-S32A/ S36A) demonstrated significantly lower superoxide release and lower CYBB gene expression compared with control U937 cells. We further tested Epstein-Barr virus (EBV)-transformed B cells from patients with anhidrotic ectodermal dysplasia with immunodeficiency (EDAID), an inherited disorder of NF-?B function (DAE-IDI?B S32I e DAE-ID NEMO/IKK? X420W). Superoxide release and CYBB gene expression by EDA-ID cells were significantly decreased compared with healthy cells and similar to cells from patients with X-linked chronic granulomatous disease (X91° CGD). Gel shift assays demonstrated loss of recombinant human p50 binding to a NF-?B site 5' to the CYBB gene inU937 cells treated with NF-?B inhibitors, repressor-transfected U937 cells, and EDA-ID patients' cells. These studies show that NF-?B is necessary for CYBB gene expression and activation of the phagocyte NADPH oxidase in this model system.
Doutorado
Doutor em Farmacologia
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Nooney, Tamsin. "Angular analysis of the B⁰d → K*⁰μ⁺μ⁻ decay with the ATLAS experiment." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/30627.
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An angular analysis of B⁰d → K⁰(→K⁺π⁻)μ⁺μ⁻ is presented using 20.3 fb⁻¹ of pp collision data collected at √s = 8 TeV with the ATLAS experiment. The angular observables FL and S₃,₄,₅,₇,₈ were extracted in six bins of q², the invariant mass squared of the dimuon system, within the full range 0.04 < q² < 6.00 (GeV/c²)². The observables were determined from an unbinned maximum likelihood fit using four folded parameterisations of the full angular distribution. The fit results were used to obtain corresponding values for the optimised observables P₁ and P'₄,₅,₆,₈. The results presented are compatible with Standard Model predictions.
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Kovalskyi, Dmytro. "Search for physics beyond the Standard Model using measurements of CP violating asymmetries in rare B decays B⁰->K⁰s pi⁰ and B⁰->Ks pi⁰ gamma /." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/3208.
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Thesis (Ph. D.) -- University of Maryland, College Park, 2005.Thesis research directed by: Dept. of Physics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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Akar, S. "Études des désintégrations B -> K pi pi gamma avec l'expérience Babar : hélicité du photon et structure résonante du système K pi pi." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2013. http://tel.archives-ouvertes.fr/tel-00998252.
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Une mesure de l'asymétrie de CP dépendante du temps des désintégrations radiatives B0 en KS pi+ pi- gamma, est effectuée à partir d'un échantillon de 470.9 millions d'événements Upsilon(4S) en BBbar enregistrés par le détecteur BaBar auprès du collisionneur asymétrique Pep-II situé au SLAC. En utilisant les événements satisfaisant m(K pi pi)<1.8 GeV/c^2, 0.60.945 GeV/c^2, les paramètres de violation de la symétrie de CP ainsi obtenus sont S(KS pi+ pi- gamma) = 0.137 pm 0.249 + 0.042 - 0.033 et C(KS pi+ pi- gamma) = -0.390 pm 0.204 + 0.045 - 0.050. À partir de ces résultats la valeur de l'asymétrie de CP dépendante du temps reliée aux états propres de CP Rho0 KS, est extraite: S(KS Rho0 gamma) = 0.249 pm 0.455 + 0.076 - 0.060. Cette observable apporte de l'information relative aux états de polarisation du photon dans les processus sous-jacents de transitions radiatives b en s gamma. En utilisant l'hypothèse de conservation de la symétrie d'isospin, l'extraction de S(KS Rho0 gamma) à partir S(KS pi+ pi- gamma) est effectuée à partir de l'étude des désintégrations B+ en K+ pi+ pi- gamma, où les amplitudes des différentes résonances intermédiaires Rho0 K+, Kstar0 pi+ et (K pi) S-wave pi+, contribuant au système K pi pi, sont mesurées. Cette étude, en plus de l'information nécessaire à l'extraction de S(KS Rho0 gamma), a permis d'extraire les contributions relatives des résonances kaoniques au système K pi pi, ainsi que les fractions globales des modes résonants Rho0 K+, Kstar0 pi+ et (K pi) S-wave pi+, constituant une source d'information utile à d'autres études sur la polarisation du photon.
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Rodrigues, Costa Ana, Celia M. Antunes, and Júlio Cruz-Morais. "Abnormal regulation of pancreatic beta cell Na,K-ATPase on glucose intolerant rats." Bachelor's thesis, Springer Berlin, 2010. http://hdl.handle.net/10174/3307.
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Background and aims: Glucose (G) is the most important physiological insulin secretagogue. It is widely accepted that, in pancreatic -cell, G evoked early ionic events such as membrane depolarization and Ca2+ influx through voltage dependent Ca2+ channels triggers insulin exocytosis. However, the role of other electrogenic systems, namely ionic pumps, to these events remains essentially uninvestigated. It is known that the activity of Na,K-ATPase is modified in type 2 diabetes (T2D). The pump is responsible for maintaining Na+ and K+ gradients across the plasma membrane and generates a net outward current as a result of 3Na+/2K+ exchange. It remains elusive whether Na,K-ATPase activity is regulated by G in pancreatic β-cell and/or this current contributes to the ionic events regulating insulin secretion.
The aim of this work was to assess G evoked regulation of Na,K-ATPase activity in intact -cells of normal and G intolerant rats.
Materials and methods: Pancreatic -cells, from normal (controls) or glucose-intolerant Wistar rats (GIR), were isolated and cultured (48h). Cell batches were pre-incubated (30min) with 2.1mM G to reach basal. Afterwards cells were challenged with [G] in the interval 0-11.1mM for 60min, for dose-dependence evaluation, or with 8.4mM G for 5-120min, for time-dependence evaluation. ATPase activity was assessed in intact cells by colorimetric quantification of Pi formed in 30min. Na,K-ATPase activity was calculated by the difference between the activities obtained in the absence and in presence the of 1mM ouabain.
Results: G evoked both time- and dose-dependent regulation of Na,K-ATPase. In β-cells from controls, G induced a bimodal regulation of Na,K-ATPase. In the absence of G, Na,K-ATPase activity was 0.056±0.015U/mg. Raising [G] to 2.1mM induced a ≈3 fold increase of Na,K-ATPase activity whereas a further increase in [G] in the interval of 5.6-11.1mM evoked a significant reduction of Na,K-ATPase activity to the levels observed in the absence of the secretagogue. Compared to 2mM G, the activity was reduced in 68%, 55% and 66% when [G] was increased to 5.6, 8.4 and 11.1mM, respectively (n=3-12). GIR β-cells exhibit an altered profile of response to the secretagogue; In the absence of G, Na,K-ATPase activity was ≈4 fold the activity observed in the controls (0.202±0.036U/mg; n=3). The pump activity remained unchanged for 2.1-5.6mM G and similar to maximal activity observed in the controls (0.188±0.035 U/mg, for 2.1mM G; n=4). A significant reduction of the pump activity in GIR β-cells was induced by 8.4mM G (0.118±0.018 U/mg).
G (8mM) induced a time-dependent inhibition of Na,K-ATPase with a biphasic profile. Pump activity decreased to a minimum value (32%) after 20min exposure to G, showing a partial recovery to 45%, 46% and 47% for 30, 60 and 120min, respectively (n=5-12). GIR β-cells showed an attenuated response to G (59% activity after 20min) without any recovery (n=5-11).
Conclusions: This work demonstrates that Na,K-ATPase is finely regulated by G in pancreatic β-cell from normal subjects. This regulation is impaired in GIR where desensitization and an attenuation of the inhibitory action of G were observed. In summary, Na,K-ATPase contribution to G-induced ionic events and insulin secretion might be relevant in T2D development.
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Malcles, Julie. ""Etude des désintégrations B+/- -> K+/- pi0 et B+/- -> pi+/- pi0 avec le détecteur BABAR et contraintes des modes B -> pipi, Kpi, KK sur la matrice CKM."." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2006. http://tel.archives-ouvertes.fr/tel-00175074.
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L'analyse des modes B+/- -> pi+/- pi0 et B+/- -> K+/- pi0 a été menée avec un échantillon de données de 205 fb-1 correspondant à environ 227 millions de paires de mésons B, collectées par le détecteur BABAR. Les rapports d'embranchement et les asymétries de CP obtenus sont: B( B+/- -> pi+/- pi0) = (5.57 +/- 0.60 +/- 0.33) 10E-6 B( B+/- -> K+/- pi0) = (11.50 +/- 0.65 +/- 0.57) 10E-6 Acp( B+/- -> pi+/- pi0) = -0.01 +/- 0.10 +/- 0.02 Acp( B+/- -> K+/- pi0)= 0.06 +/- 0.06 +/- 0.01 Les contraintes sur l'angle le triangle d'unitarité par les analyses d'isospin des modes pi pi et K pi ont été étudiées. Des contraintes plus significatives ont été obtenues avec la symétrie SU(3) pour les modes B, Bs -> pipi/ Kpi / KK. Elles sont en bon accord avec l'ajustement CKM standard. Dans le futur une telle analyse pourrait entrer en compétition avec l'ajustement CKM standard, et permettre de déterminer des paramètres de Nouvelle Physique ou de brisure de SU(3) à partir des données.
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Aspinwall, Marie-Louise. "Measurement of the exclusive branching fractions and asymmetries of B-> pi K at BaBar." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271425.
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Wagner, Anna [Verfasser], and Ulrich [Akademischer Betreuer] Lohbauer. "Messung der Polymerisationsschrumpfung und Sauerstoffinhibitionsschicht verschiedener K&B-Materialien / Anna Wagner. Gutachter: Ulrich Lohbauer." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2015. http://d-nb.info/1076166423/34.
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Maganhi, Stella Hernandez. "Estudos estruturais de compostos de telúrio e de docking em catepsinas B, K, L, S." Universidade Federal de São Carlos, 2013. https://repositorio.ufscar.br/handle/ufscar/6262.
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Previous issue date: 2013-03-28Universidade Federal de Minas Gerais
Cathepsins are lysosomal cysteine proteases responsible for protein turnover in our organism. In non-lysosomal environment they are related to a number of diseases such as cancer, Alzheimer, autoimmune diseases and osteoporosis. Tellurium compounds have proved to be promising therapeutic agents against these diseases due to inhibition of the proteases through the formation of a Te S covalent bond with the sulfur of a catalytic cysteine. In this work the crystal and molecular structures of compounds (ptol)Te[C(H)=C(Cl)Ph]X2 (X = Cl, Br, I), butyldiiodo[(1Z)-(2- iodopent-1-en-yl)-4- tellane and their docking in Catepsine B are described. The results showed that these compounds, whose activity has not been measured, should have an inhibitory activity very similar to that of a known compound with a close structure. Moreover, it is shown that the substitution of a phenyl group for an aliphatic one should not have any influence on the activity of these kind of compounds. Also the structures of a series of dipnones were determined which were used as basis for the molecular modeling of others that could not be crystallized and for the docking studies in catepsins B, K, L and S. The results allowed establishing a model that explains their different inhibitory activities.
As catepsinas são cisteíno proteases lisossômicas presentes no nosso organismo. Quando em ambiente não lisossômico, estão relacionadas a uma série de doenças como câncer, Alzheimer, doenças autoimunes e osteoporose. Neste contexto, compostos de telúrio têm sido promissores agentes terapêuticos contra estas doenças por apresentarem ação inibitória das catepsinas. Isso ocorre devido à formação de uma ligação covalente entre telúrio e o enxofre da cisteína catalítica. Neste trabalho são descritas as estruturas cristalinas e moleculares dos compostos (ptol)Te[C(H)=C(Cl)Ph]X2 (X = Cl, Br, I), butildiiodo[(1Z)-(2-iodopent-1-em-1-il) 4- telano, e o docking destes compostos em Catepsina B. Os resultados mostram que estes compostos, cujas atividades não foram medidas, poderão apresentar atividades inibitórias semelhantes à de um composto de estrutura similar e com atividade conhecida. Mais ainda, foi mostrado que a substituição de um grupo fenila por um grupo alifático não deverá ter influência na atividade deste tipo de compostos. Foram também determinadas as estruturas cristalinas e moleculares de três dipnonas. Estas estruturas serviram de base para a modelagem das estruturas de outros compostos que não puderam ser cristalizados e para a realização de docking nas catepsinas B, K, L, e S. Foi então estabelecido um modelo para explicar as diferentes atividades inibitórias dos compostos de telúrio.
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Fourman, Cody. "Targeting oncogenic K-Ras and monoamine oxidase B utilizing chalcones bearing the 3,4,5-trimethoxyphenyl motif." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1596823680746445.
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Thérin, Guillaume. "Etude de la violation de CP dans les désintégrations B± → D0 K*± sur l' expérience BaBar à SLAC." Paris 7, 2005. https://tel.archives-ouvertes.fr/tel-00010059v3.
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BAUMGARTNER, MARTIN. "Activation constitutive et parasite dependante de la pi3-k : les fonctions regulatrices de la pi3-k dans des cellules b transformees par theileria parva." Paris 6, 2001. http://www.theses.fr/2001PA066266.
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L'objective de ce travail etait l'identification des mecanismes moleculaires qui controlent la proliferation et la survie des cellules infectees par le parasite protozoaire theileria. Nous nous sommes focalises sur la phosphoinositde 3-kinase (pi3-k) et la famille des src kinases, deux regulateurs majeurs des voies de signalisation des cellules eucaryotes. Nous avons pu demontrer que la pi3-k est activee de facon constitutive dans des cellules b infectees par t. Parva. L'activation de la pi3-k est strictement dependante de la presence intracytoplasmique du parasite et engendre la proliferation des cellules infectees par theileria en controlant la transition g1-s et g2/m. Contrairement a son role cle dans la proliferation, la pi3-k ne contribue pas a la protection antiapoptotic des cellules infectees. Conforme a cette notion, nous avons pu demontrer que la proteine kinase b (pkb), un mediateur majeur dans la voie antiapoptotic induit par la pi3-k, n'est pas activee dans des cellules b infectees. En outre, nous avons pu demontrer que l'activation de la pi3-k est a l'origine de l'expression et de la secretion de gm-csf. Le facteur gm-csf contribue a la proliferation de maniere autocrine et, de plus, regule l'etat d'activation de hck, une kinase de la famille src. L'inhibition pharmacologique des src kinases provoque un arret de proliferation, suggerant que des kinases de la famille src et la pi3-k soient requises pour la transformation des lymphocytes par theileria. Conformement, l'activation du facteur de transcription ap-1 depend de l'action combinee de hck et pi3-k. Contrairement a la pi3-k, l'activite et l'etat de phosphorylation de hck augmentent suite a l'elimination du parasite suggerant que l'activite finale de hck resulte de la combinaison des signaux positifs et negatifs, tous deux controles par le parasite. Nous proposons que hck ait regule par un mecanisme base sur l'exclusion de csk de la fraction membranaire enrichi en glycosphingolipides et par un mecanisme inconnu qui depend de la pi3-k. Le fait que l'activation de hck est controlee de facon negative par la pi3-k indique que la transformation dependante de theileria et donc la dissemination du parasite est determinee par la regulation positive et negative des voies de signalisation de la cellule hote.
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Bu, De-xiu. "The nuclear factor k[kappa]B signal transduction pathway : its role in atherogenesis and intimal hyperplasia /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-615-8/.
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