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Journal articles on the topic 'E171 additive'

Author: Grafiati

Published: 31 August 2024

Last updated: 31 July 2025

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1

Verleysen, Eveline, Nadia Waegeneers, Frédéric Brassinne, et al. "Physicochemical Characterization of the Pristine E171 Food Additive by Standardized and Validated Methods." Nanomaterials 10, no. 3 (2020): 592. http://dx.doi.org/10.3390/nano10030592.

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E171 (titanium dioxide) is a food additive that has been authorized for use as a food colorant in the European Union. The application of E171 in food has become an issue of debate, since there are indications that it may alter the intestinal barrier. This work applied standardized and validated methodologies to characterize representative samples of 15 pristine E171 materials based on transmission electron microscopy (TEM) and single-particle inductively coupled plasma mass spectrometry (spICP-MS). The evaluation of selected sample preparation protocols allowed identifying and optimizing the c

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2

Hwang, Ji-Soo, Jin Yu, Hyoung-Mi Kim, Jae-Min Oh, and Soo-Jin Choi. "Food Additive Titanium Dioxide and Its Fate in Commercial Foods." Nanomaterials 9, no. 8 (2019): 1175. http://dx.doi.org/10.3390/nano9081175.

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Titanium dioxide (TiO2) is one of the most extensively utilized food additives (E171) in the food industry. Along with nanotechnology development, the concern about the presence of nanostructured particles in E171 TiO2 and commercial food products is growing. In the present study, the physicochemical properties of commercially available E171 TiO2 particles, including particle size distribution, were investigated, followed by their cytotoxicity and intestinal transport evaluation. The fate determination and quantification of E171 TiO2 in commercial foods were carried out based on the analytical

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3

Ferrante, Margherita, Alfina Grasso, Rossella Salemi, et al. "DNA Damage and Apoptosis as In-Vitro Effect Biomarkers of Titanium Dioxide Nanoparticles (TiO2-NPs) and the Food Additive E171 Toxicity in Colon Cancer Cells: HCT-116 and Caco-2." International Journal of Environmental Research and Public Health 20, no. 3 (2023): 2002. http://dx.doi.org/10.3390/ijerph20032002.

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This study investigated the DNA damage and apoptosis in colon cancer cells HCT-116 and Caco-2 induced by engineered titanium dioxide nanoparticles (TiO2-NPs) (60 nm) and titanium dioxide food additive E171. MTT assays showed that both chemical forms significantly reduced cancer cell viability in a dose-dependent manner. In particular the food additive E171 induced a pronounced inhibitory effect on the growth of HCT-116 and Caco-2 cell lines (E171 IC50: 3.45 mg/L for HTC-116 and 1.88 mg/L Caco-2; TiO2-NPs 60 nm IC50: 41.1 mg/L for HTC-116 and 14.3 mg/L for Caco-2). A low level of genotoxicity w

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4

Tsareva, Anastasiya A., Olga V. Egorova, Yuliya V. Demidova, and Nataliya A. Ilyushina. "Studying the ability of the food additive E171 (titanium dioxide) to induce gene mutations in bacteria." Hygiene and sanitation 102, no. 12 (2023): 1361–66. http://dx.doi.org/10.47470/0016-9900-2023-102-12-1361-1366.

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Introduction. Titanium dioxide in the Russian Federation is approved for use in the food industry, in the production of medicines and hygiene products. The food additive E171 is a mixture of micro- and nanoparticles of TiO2. In 2010, IARC classified TiO2 in nanoform as a probably carcinogenic to humans (Group 2B). In vitro and in vivo studies of the genotoxicity of titanium dioxide revealed contradictory results, indicating both the presence and absence of TiO2 mutagenicity.  The aim of the work is to evaluate the mutagenicity of the food additive E171 in the Ames test using standard and

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5

Bischoff, Nicolaj S., Héloïse Proquin, Marlon J. Jetten, et al. "The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer." Nanomaterials 12, no. 8 (2022): 1256. http://dx.doi.org/10.3390/nano12081256.

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Titanium dioxide (TiO2) is present in many different food products as the food additive E171, which is currently scrutinized due to its potential adverse effects, including the stimulation of tumor formation in the gastrointestinal tract. We developed a transgenic mouse model to examine the effects of E171 on colorectal cancer (CRC), using the Cre-LoxP system to create an Apc-gene-knockout model which spontaneously develops colorectal tumors. A pilot study showed that E171 exposed mice developed colorectal adenocarcinomas, which were accompanied by enhanced hyperplasia in epithelial cells, lym

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6

Brassinne, F., S. De Vos, E. Verleysen, P. J. De Temmerman, M. Ledecq, and J. Mast. "Characterization of the TiO2 E171 food additive." Toxicology Letters 295 (October 2018): S208. http://dx.doi.org/10.1016/j.toxlet.2018.06.909.

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7

Rudometkina, T. F. "PHOTOMETRIC DETERMINATION OF E171 ADDITIVE IN FOOD PRODUCTS." EurasianUnionScientists 5, no. 63 (2019): 56–59. http://dx.doi.org/10.31618/esu.2413-9335.2019.5.63.177.

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8

Dorier, Marie, David Béal, Céline Tisseyre, et al. "The food additive E171 and titanium dioxide nanoparticles indirectly alter the homeostasis of human intestinal epithelial cells in vitro." Environmental Science: Nano 6, no. 5 (2019): 1549–61. http://dx.doi.org/10.1039/c8en01188e.

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9

Song, In-Gyu, Kanghee Kim, Hakwon Yoon, and June Woo Park. "Toxicity assessment of food additive (E171) in aquatic environments." Environmental Biology Research 41, no. 1 (2023): 41–53. http://dx.doi.org/10.11626/kjeb.2023.41.1.041.

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10

Baranowska-Wójcik, Ewa, Klaudia Gustaw, Dominik Szwajgier, et al. "Four Types of TiO2 Reduced the Growth of Selected Lactic Acid Bacteria Strains." Foods 10, no. 5 (2021): 939. http://dx.doi.org/10.3390/foods10050939.

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Food-grade titanium dioxide (TiO2) containing a nanoparticle fraction (TiO2 NPs -nanoparticles) is widely used as a food additive (E171 in the EU). In recent years, it has increasingly been raising controversies as to the presence or absence of its harmful effects on the gastrointestinal microbiota. The complexity and variability of microbiota species present in the human gastrointestinal tract impede the assessment of the impact of food additives on this ecosystem. As unicellular organisms, bacteria are a very convenient research model for investigation of the toxicity of nanoparticles. We ex

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11

Baranowska-Wójcik, Ewa, Anna Rymuszka, Anna Sierosławska, and Dominik Szwajgier. "Effect of Food Additive E171 and Titanium Dioxide Nanoparticles (TiO2-NPs) on Caco-2 Colon Cancer Cells." Applied Sciences 14, no. 20 (2024): 9387. http://dx.doi.org/10.3390/app14209387.

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The food coloring agent E171 raises many questions concerning its negative impact on human health because of the fact that it contains nanoparticle fractions (NPs, diameter < 100 nm). Numerous studies showed its influence on organisms, including the ability to disrupt the intestinal barrier. In the present study, we verified the potential toxicity and pro-inflammatory activity of three different E171 samples (containing NPs fractions) and one TiO2 NPs sample (60–600 µg mL−1) towards Caco-2 colon cancer cells. The experiments revealed no significant changes in terms of the vitality of Caco-2

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12

PONTI, Jessica. "Extraction of E171 or E172 food additives from sugar-based or lipid-based complex matrices for primary particles identification by electron microscopy." Open Research Europe 4 (December 18, 2024): 265. https://doi.org/10.12688/openreseurope.18678.1.

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Measurement of primary particle size distributions is fundamental to determining if a material should be classified as a nanomaterial according to the European Commission recommended definition. This is of particular relevance to alimentary products, where current regulation requires that any additives containing nanoforms be explicitly declared as such in the ingredients’ list. Currently, Electron Microscopy is the only instrumental technique able to reliably classify materials as nanomaterials. To verify the nanostatus of a material using this technique, it is essential to firstly extract th

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13

Grasso, Alfina, Margherita Ferrante, Pietro Zuccarello, et al. "Chemical Characterization and Quantification of Titanium Dioxide Nanoparticles (TiO2-NPs) in Seafood by Single-Particle ICP-MS: Assessment of Dietary Exposure." International Journal of Environmental Research and Public Health 17, no. 24 (2020): 9547. http://dx.doi.org/10.3390/ijerph17249547.

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The significant increase in the production and variety of nanoparticles (NPs) has led to their release into the environment, especially into the marine environment. Titanium dioxide nanoparticles (TiO2-NPs) are used in different industrial sectors, from the food industry to several consumer and household products. Since the aquatic environment is highly sensitive to contamination by TiO2-NPs, this work aimed to give a preliminary assessment of the contamination of packaged seafood, where the food additive TiO2 (E171) is not to be intentionally added. This allowed providing a chemical character

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14

Krivobok, V. S., A. V. Kolobov, S. E. Dimitrieva, et al. "Raman Markers of Toxic Nanofraction in Anatase TiO2 Micropowder Used as E171 Food Additive." Journal of Russian Laser Research 42, no. 4 (2021): 388–98. http://dx.doi.org/10.1007/s10946-021-09974-1.

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15

Proquin, Héloïse, Marlon J. Jetten, Marloes C. M. Jonkhout, et al. "Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171)." Food and Chemical Toxicology 111 (January 2018): 153–65. http://dx.doi.org/10.1016/j.fct.2017.11.011.

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16

Blaznik, Urška, Sanja Krušič, Maša Hribar, Anita Kušar, Katja Žmitek, and Igor Pravst. "Use of Food Additive Titanium Dioxide (E171) before the Introduction of Regulatory Restrictions Due to Concern for Genotoxicity." Foods 10, no. 8 (2021): 1910. http://dx.doi.org/10.3390/foods10081910.

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Food-grade titanium dioxide (TiO2; E171) is a coloring food additive. In May 2021, a scientific opinion was published by the European Food Safety Authority concluding that TiO2 can no longer be considered as a safe food additive. Our aim was to investigate the trends in the use of TiO2 in the food supply. A case study was conducted in Slovenia using two nationally representative cross-sectional datasets of branded foods. Analysis was performed on N = 12,644 foods (6012 and 6632 in 2017 and 2020, respectively) from 15 food subcategories where TiO2 was found as a food additive. A significant dec

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17

Proquin, Héloïse, Carolina Rodríguez-Ibarra, Carolyn G. J. Moonen, et al. "Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions." Mutagenesis 32, no. 1 (2016): 139–49. http://dx.doi.org/10.1093/mutage/gew051.

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18

Proquin, Héloïse, Carolina Rodríguez-Ibarra, Carolyn Moonen, et al. "Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions." Mutagenesis 33, no. 3 (2018): 267–68. http://dx.doi.org/10.1093/mutage/gey011.

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19

Bischoff, N. S., S. G. Breda, J. J. Briedé, et al. "P13-25 Evaluating the effects of food additive E171 on colorectal cancer risk: a human dietary intervention study." Toxicology Letters 399 (September 2024): S220. http://dx.doi.org/10.1016/j.toxlet.2024.07.541.

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20

Bellani, Lorenza, Simonetta Muccifora, Francesco Barbieri, Eliana Tassi, Monica Ruffini Castiglione, and Lucia Giorgetti. "Genotoxicity of the food additive E171, titanium dioxide, in the plants Lens culinaris L. and Allium cepa L." Mutation Research/Genetic Toxicology and Environmental Mutagenesis 849 (January 2020): 503142. http://dx.doi.org/10.1016/j.mrgentox.2020.503142.

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21

Bischoff, Nicolaj S., Theo M. de Kok, Dick T. H. M. Sijm, et al. "Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System." International Journal of Molecular Sciences 22, no. 1 (2020): 207. http://dx.doi.org/10.3390/ijms22010207.

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Titanium dioxide (TiO2) is used as a food additive (E171) and can be found in sauces, icings, and chewing gums, as well as in personal care products such as toothpaste and pharmaceutical tablets. Along with the ubiquitous presence of TiO2 and recent insights into its potentially hazardous properties, there are concerns about its application in commercially available products. Especially the nano-sized particle fraction (<100 nm) of TiO2 warrants a more detailed evaluation of potential adverse health effects after ingestion. A workshop organized by the Dutch Office for Risk Assessment and Re

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22

Brugiroux, Sandrine, Thomas Sauvaitre, Gwenaelle Roche, et al. "Su1976 – Impacts of Additive Food E171 (Titanium Dioxide) on the Gut Microbiota and Colorectal Carcinogenesis in ApcMIN/+ Murine Model." Gastroenterology 156, no. 6 (2019): S—679. http://dx.doi.org/10.1016/s0016-5085(19)38610-x.

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23

A.R.Ergashov. "THE IMPORTANCE OF E171 DYE IN THE FOOD INDUSTRY AND ITS EFFECT ON THE BODY." INTERNATIONAL BULLETIN OF MEDICAL SCIENCES AND CLINICAL RESEARCH 3, no. 5 (2023): 284–88. https://doi.org/10.5281/zenodo.8000688.

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TiO2 (E 171) is a pigment used to alter the visual properties of food and beverages. It is also used in cosmetics, pharmaceuticals, and toothpastes, which means that we may also come in contact with the substance while taking medicines or using personal hygiene products such as toothpastes or mouthwashes. Titanium dioxide (TiO2) nanoparticles (NPs) have been widely applied in various industrial fields, such as electronics, packaging, food, and cosmetics. Titanium dioxide (TiO2) is commonly applied to enhance the white colour and brightness of food products. TiO2 is also used as white pigment i

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24

Gmoshinski, I. V., O. V. Bagryantseva, and S. A. Khotimchenko. "Toxicological and hygienic assessment of titanium dioxide nanoparticles as a component of E171 food additive (review of the literature and metahanalysis)." Health Risk Analysis, no. 2 (June 2019): 145–63. http://dx.doi.org/10.21668/health.risk/2019.2.17.

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25

Gmoshinski, I. V., O. V. Bagryantseva, and S. A. Khotimchenko. "Toxicological and hygienic assessment of titanium dioxide nanoparticles as a component of E171 food additive (review of the literature and metahanalysis)." Health Risk Analysis, no. 2 (June 2019): 145–63. http://dx.doi.org/10.21668/health.risk/2019.2.17.eng.

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26

Talamini, Laura, Sara Gimondi, Martina B. Violatto, et al. "Repeated administration of the food additive E171 to mice results in accumulation in intestine and liver and promotes an inflammatory status." Nanotoxicology 13, no. 8 (2019): 1087–101. http://dx.doi.org/10.1080/17435390.2019.1640910.

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27

Warheit, D. "P24-38: EFSA Made a Manifest Error on the Safety of Titanium Dioxide (E171) Particles as a Food Additive for Humans." Toxicology Letters 384 (September 2023): S279. http://dx.doi.org/10.1016/s0378-4274(23)00920-7.

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28

Bencherit, Djihad, Kheira Laoues, Imane Karboua, and Mohamed Lounis. "Survey of harmful dyes in food color additives in Algeria." Electronic Journal of Medical and Dental Studies 13, no. 3 (2023): em0106. http://dx.doi.org/10.29333/ejmds/13105.

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Food colors are pervasive in our diet. However, some of them are involved in health concerns reaching carcinogenicity and reproductive toxicity. This is a survey of prepackaged color additives marketed to the simple consumer in Algeria. This exploration aimed to assess the compliance of the labeling of color additives, as well as the investigation of the presence of harmful dyes, namely E102, E110, E 121, E122, E123, E124, E127, E129, E132, E133, E143, and E171, in their composition. Our findings reveal the labeling compliance of 50.5% of analyzed coloring products and the absence of ingredien

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29

Dorier, Marie, Céline Tisseyre, Fanny Dussert, et al. "Toxicological impact of acute exposure to E171 food additive and TiO2 nanoparticles on a co-culture of Caco-2 and HT29-MTX intestinal cells." Mutation Research/Genetic Toxicology and Environmental Mutagenesis 845 (September 2019): 402980. http://dx.doi.org/10.1016/j.mrgentox.2018.11.004.

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30

Tassinari, Roberta, Alessia Tammaro, Andrea Martinelli, Mauro Valeri, and Francesca Maranghi. "Sex-Specific Effects of Short-Term Oral Administration of Food-Grade Titanium Dioxide Nanoparticles in the Liver and Kidneys of Adult Rats." Toxics 11, no. 9 (2023): 776. http://dx.doi.org/10.3390/toxics11090776.

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Titanium dioxide (TiO2) nanomaterial is used in several items (implant materials, pills composition, cosmetics, etc.). Although TiO2 is no longer considered safe as a food additive, the general population is exposed daily through different routes, and information is lacking on some aspects of animal and human health. This study evaluated liver and kidney toxicity of food-grade TiO2 nanoparticles (NPs) (primary size < 25 nm) in male and female rats that were orally exposed for 5 days to 0, 1, and 2 mg/kg body weight per day (comparable with daily E171 consumption). Selected liver and kidney

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31

Bucher, Guillaume, Hind El Hadri, Océane Asensio, François Auger, Josefa Barrero, and Jean-Philippe Rosec. "Large-scale screening of E171 food additive (TiO2) on the French market from 2018 to 2022: Occurrence and particle size distribution in various food categories." Food Control 155 (January 2024): 110102. http://dx.doi.org/10.1016/j.foodcont.2023.110102.

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32

Laisney, Jérôme, Mireille Chevallet, Caroline Fauquant, et al. "Ligand-Promoted Surface Solubilization of TiO2 Nanoparticles by the Enterobactin Siderophore in Biological Medium." Biomolecules 12, no. 10 (2022): 1516. http://dx.doi.org/10.3390/biom12101516.

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Titanium dioxide nanoparticles (TiO2-NPs) are increasingly used in consumer products for their particular properties. Even though TiO2 is considered chemically stable and insoluble, studying their behavior in biological environments is of great importance to figure their potential dissolution and transformation. The interaction between TiO2-NPs with different sizes and crystallographic forms (anatase and rutile) and the strong chelating enterobactin (ent) siderophore was investigated to look at a possible dissolution. For the first time, direct evidence of anatase TiO2-NP surface dissolution o

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33

Wang, Yidan, Allan Sauvat, Celine Lacrouts, et al. "TiO2 Nanomaterials Non-Controlled Contamination Could Be Hazardous for Normal Cells Located in the Field of Radiotherapy." International Journal of Molecular Sciences 21, no. 3 (2020): 940. http://dx.doi.org/10.3390/ijms21030940.

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Among nanomaterials (NMs), titanium dioxide (TiO2) is one of the most manufactured NMs and can be found in many consumers’ products such as skin care products, textiles and food (as E171 additive). Moreover, due to its most attractive property, a photoactivation upon non-ionizing UVA radiation, TiO2 NMs is widely used as a decontaminating agent. Uncontrolled contaminations by TiO2 NMs during their production (professional exposure) or by using products (consumer exposure) are rather frequent. So far, TiO2 NMs cytotoxicity is still a matter of controversy depending on biological models, types o

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34

Espada-Bernabé, Elena, Gustavo Moreno-Martín, Beatriz Gómez-Gómez, and Yolanda Madrid. "Assesing the behaviour of particulate/nanoparticulate form of E171 (TiO2) food additive in colored chocolate candies before and after in vitro oral ingestion by spICP-MS, TEM and cellular in vitro models." Food Chemistry 432 (January 2024): 137201. http://dx.doi.org/10.1016/j.foodchem.2023.137201.

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35

Bischoff, Nicolaj, Héloïse Proquin, Marlon Jetten, et al. "Correction: Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12, 1256." Nanomaterials 13, no. 21 (2023): 2888. http://dx.doi.org/10.3390/nano13212888.

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36

Kaminski, Norbert E., and Samuel M. Cohen. "Comment on Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12, 1256." Nanomaterials 13, no. 9 (2023): 1551. http://dx.doi.org/10.3390/nano13091551.

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37

Bautista-Pérez, Rocío, Agustina Cano-Martínez, Manuel Alejandro Herrera-Rodríguez, et al. "Oral Exposure to Titanium Dioxide E171 and Zinc Oxide Nanoparticles Induces Multi-Organ Damage in Rats: Role of Ceramide." International Journal of Molecular Sciences 25, no. 11 (2024): 5881. http://dx.doi.org/10.3390/ijms25115881.

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Food-grade titanium dioxide (E171) and zinc oxide nanoparticles (ZnO NPs) are common food additives for human consumption. We examined multi-organ toxicity of both compounds on Wistar rats orally exposed for 90 days. Rats were divided into three groups: (1) control (saline solution), (2) E171-exposed, and (3) ZnO NPs-exposed. Histological examination was performed with hematoxylin–eosin (HE) staining and transmission electron microscopy (TEM). Ceramide (Cer), 3-nitrotyrosine (NT), and lysosome-associated membrane protein 2 (LAMP-2) were detected by immunofluorescence. Relevant histological cha

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38

Waegeneers, Nadia, Sandra De Vos, Eveline Verleysen, Ann Ruttens, and Jan Mast. "Estimation of the Uncertainties Related to the Measurement of the Size and Quantities of Individual Silver Nanoparticles in Confectionery." Materials 12, no. 17 (2019): 2677. http://dx.doi.org/10.3390/ma12172677.

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E174 (silver) is a food additive that may contain silver nanoparticles (AgNP). Validated methods are needed to size and quantify these particles in a regulatory context. However, no validations have yet been performed with food additives or real samples containing food additives requiring a sample preparation step prior to analysis. A single-particle inductively coupled plasma mass spectrometry (spICP-MS) method was developed and validated for sizing and quantifying the fraction of AgNP in E174 and in products containing E174, and associated uncertainties related to sample preparation, analysi

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Vitulo, Manuela, Elisa Gnodi, Raffaella Meneveri, and Donatella Barisani. "Interactions between Nanoparticles and Intestine." International Journal of Molecular Sciences 23, no. 8 (2022): 4339. http://dx.doi.org/10.3390/ijms23084339.

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The use of nanoparticles (NPs) has surely grown in recent years due to their versatility, with a spectrum of applications that range from nanomedicine to the food industry. Recent research focuses on the development of NPs for the oral administration route rather than the intravenous one, placing the interactions between NPs and the intestine at the centre of the attention. This allows the NPs functionalization to exploit the different characteristics of the digestive tract, such as the different pH, the intestinal mucus layer, or the intestinal absorption capacity. On the other hand, these sa

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40

Pannek, Carolin, Karina R. Tarantik, Laura Engel, Thomas Vetter, and Jürgen Wöllenstein. "Gasochromic Detection of NO2 on the Example of the Food Additive E141 (ii)." Proceedings 2, no. 13 (2018): 721. http://dx.doi.org/10.3390/proceedings2130721.

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We present our investigation on the gasochromic reaction of E141 (ii) towards the toxic gas nitrogen dioxide (NO2). E141 (ii) is a chlorophyllin-based food additive, typically used as green coloring for nearly all kinds of sweets. In this presentation we show an alternative approach for using E141 (ii) as optical gas indicator. All solid samples are prepared by multi-layer screen printing on different substrates like paper and PE-foil. Gas measurements are performed using an UV/Vis spectrometer. The influence of the substrate and according layer thickness is shown.

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41

Bischoff, Nicolaj S., Héloïse Proquin, Marlon J. Jetten, et al. "Reply to Kaminski, N.E.; Cohen, S.M. Comment on “Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12, 1256”." Nanomaterials 13, no. 9 (2023): 1552. http://dx.doi.org/10.3390/nano13091552.

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42

Abuzaid, Hanan O., Abdelmnim M. Altwaiq, Leen N. Ali, Manal Alkhabbas, and Sa’ib Khouri. "Quantitative Analysis of Titanium Dioxide (TiO2) Levels as Food Additives in Various Food Samples from the Jordanian Market." Methods and Objects of Chemical Analysis 20, no. 2 (2025): 135–42. https://doi.org/10.17721/moca.2025.135-142.

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This study presents a quantitative determination of titanium dioxide (TiO2, E171) in food products frequently consumed by children. An optimized acid digestion method using concentrated sulfuric acid, nitric acid, and hydrogen peroxide at 200 °C for 45 minutes was developed to efficiently extract TiO2 from food matrices. The recovered TiO2 was quantified using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) and UV–Visible spectrophotometry. Both methods were successfully applied to twentyfive food products from the Jordanian market, including chewing gums, candies, and powde

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43

De Vos, Sandra, Nadia Waegeneers, Eveline Verleysen, Karen Smeets, and Jan Mast. "Physico-chemical characterisation of the fraction of silver (nano)particles in pristine food additive E174 and in E174-containing confectionery." Food Additives & Contaminants: Part A 37, no. 11 (2020): 1831–46. http://dx.doi.org/10.1080/19440049.2020.1809719.

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44

Aldabayan, Yousef Saad. "Effect of Artificial Food Additives on Lung Health—An Overview." Medicina 61, no. 4 (2025): 684. https://doi.org/10.3390/medicina61040684.

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This review focuses on the potential health risks of artificial food additives, especially their effects on lung health. Preservatives, synthetic colorants, and flavor enhancers, which are commonly used in processed foods, play roles in worsening respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). These additives cause oxidative stress, systemic inflammation, and immune dysregulation, often through the gut-lung axis. The preservatives sodium nitrite and sulfites have the risk of causing bronchial hyper-responsiveness and allergic reactions. The synthetic colo

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ABDULLAHI, Xhabir, Gafur XHABIRI, Erhan SULEJMANI, and Faton SELIMI. "The effect of some additives on the rheology of dough and quality of bread." Acta agriculturae Slovenica 118, no. 2 (2022): 1. http://dx.doi.org/10.14720/aas.2022.118.2.2601.

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<p class="042abstractstekst"><span lang="EN-US">The technology of production of baking products today can not be imagined without the use of food additives. In this research it was aimed to investigate the use of some additives in wheat flour type 500 for bread production. The formulations and additives used in this study are: without additives for M0, emulsifiers (E 472e) for M1, calcium phosphate (E341 ii) for M2, L-ascorbic acid (E300) for M3 and Damil additive complex (antifouling E170 - 0.06 %; emulsifier E472e -0.08 %; antioxidant E300 -0.01 %; fungal a-amylase - 0.01 %) for

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Zucchetti, Andrés E., Ismael R. Barosso, Andrea Boaglio та ін. "Prevention of estradiol 17β-d-glucuronide–induced canalicular transporter internalization by hormonal modulation of cAMP in rat hepatocytes". Molecular Biology of the Cell 22, № 20 (2011): 3902–15. http://dx.doi.org/10.1091/mbc.e11-01-0047.

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In estradiol 17β-d-glucuronide (E17G)–induced cholestasis, the canalicular hepatocellular transporters bile salt export pump (Abcb11) and multidrug-resistance associated protein 2 (Abcc2) undergo endocytic internalization. cAMP stimulates the trafficking of transporter-containing vesicles to the apical membrane and is able to prevent internalization of these transporters in estrogen-induced cholestasis. Hepatocyte levels of cAMP are regulated by hormones such as glucagon and adrenaline (via the β2 receptor). We analyzed the effects of glucagon and salbutamol (a β2 adrenergic agonist) on functi

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Oktaviani, Amelia, Muhammad Agus Suprayudi, Mia Setiawati, and Ichsan Achmad Fauzi. "Evaluation of food digestibility in Nile tilapia fish Oreochromis niloticus given NSP enzymes and organic chromiium." Jurnal Akuakultur Indonesia 24, no. 1 (2025): 136–47. https://doi.org/10.19027/jai.24.1.136-147.

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Feed is a crucial factor in tilapia farming because it contributes 92% of the total production cost. This study aims to evaluate the digestibility and utilization of carbohydrates in low-protein feed supplemented with NSP enzymes and organic chromium. The research method employed a factorial completely randomized design with treatments of organic chromium (0, 1, 2) and NSP enzymes (0, 1). The study used 18 aquariums, each measuring 50×40×35 cm. The fish used were tilapia with an average weight of 33.09 ± 0.06 g per fish. The feed used was commercial feed supplemented with organic chromium and

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Williams, Sally R., Tareq A. Juratli, Brandyn A. Castro, et al. "Genomic Analysis of Posterior Fossa Meningioma Demonstrates Frequent AKT1 E17K Mutations in Foramen Magnum Meningiomas." Journal of Neurological Surgery Part B: Skull Base 80, no. 06 (2019): 562–67. http://dx.doi.org/10.1055/s-0038-1676821.

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Objective Posterior fossa meningiomas are surgically challenging tumors that are associated with high morbidity and mortality. We sought to investigate the anatomical distribution of clinically actionable mutations in posterior fossa meningioma to facilitate identifying patients amenable for systemic targeted therapy trials. Methods Targeted sequencing of clinically targetable AKT1, SMO, and PIK3CA mutations was performed in 61 posterior fossa meningioma using Illumina NextSeq 500 to a target depth of >500 × . Samples were further interrogated for 53 cancer-relevant RNA fusions by the Arche

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Fang, Luo. "The Effectiveness and Safety of 42°C Pulsed Radiofrequency Combined with 60°C Continuous Radiofrequency for Refractory Infraorbital Neuralgia: A Prospective Study." Pain Physician 3, no. 22;3 (2019): E171—E179. http://dx.doi.org/10.36076/ppj/2019.22.e171.

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Background: Infraorbital neuralgia, one of the rare causes of facial pain, lacks systematic treatment guidelines because few studies on the topic have been published. We previously found that 42°C percutaneous nondestructive pulsed radiofrequency (PRF) treatment could achieve satisfactory pain relief for infraorbital neuralgia patients. However, patients who responded poorly to PRF had no other ideal treatment options until now. Recently, standard PRF combined with 60°C continuous radiofrequency (CRF) was successfully performed on trigeminal neuralgia patients and achieved a promising effectiv

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Dydykin, A. S., E. R. Vasilevskaya, M. A. Aslanova, et al. "Development of a dietary supplement with iron oxide nanoparticles and study of its chronic toxicity and biological effects." Food systems 8, no. 1 (2025): 114–23. https://doi.org/10.21323/2618-9771-2025-8-1-114-123.

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Anemia is a global public health problem, the main cause of which is iron deficiency in the body. The difficulty of enriching the diet with iron is explained by the oxidative nature of iron, which leads to undesirable sensory changes and a decrease in the quality and shelf life of food. The work is devoted to the selection of bioavailable forms of iron, which, when added to food in an appropriate amount, are not rejected by the body. The aim of the work was to study in experiments on laboratory rats the chronic toxicity and effectiveness of the developed dietary supplement “PoliFerVit” in comp

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