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Dissertations / Theses on the topic 'EAAT4'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Hiltscher, Juliane. "Glutamattransporter und genetisch bedingte Ataxien. Mutationssuche im EAAT1- und EAAT4-Gen." Lübeck Zentrale Hochschulbibliothek Lübeck, 2010. http://d-nb.info/1000297667/34.

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2

Hiltscher, Juliane [Verfasser]. "Glutamattransporter und genetisch bedingte Ataxien : Mutationssuche im EAAT1- und EAAT4-Gen / Juliane Hiltscher." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2010. http://d-nb.info/1000297667/34.

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3

Agarwal, Shailesh Ramjilal. "Pharmacological modeling and regulation of excitatory amino acid transporters (EAATS)." CONNECT TO THIS TITLE ONLINE, 2007. http://etd.lib.umt.edu/theses/available/etd-09262007-111510/.

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4

Fromm, Andrea. "Mutationsscreening und alternative Spleißvarianten des Glutamattransporters EAAT2 bei amyotropher Lateralsklerose." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-66108.

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5

Felbecker, Ansgar. "Neue 5'-Isoformen des Glutamattransporters EAAT2: RNA-Sequenzen und genomische Organisation." [S.l.] : Universität Ulm , Medizinische Fakultät, 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10913301.

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6

Köchert, Karl. "Development of a method to assess EAAT1 transcription levels in Alzheimer's disease." Master's thesis, Universität Potsdam, 2007. http://opus.kobv.de/ubp/volltexte/2008/1596/.

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Zur Zeit leiden ca. 24 Millionen Menschen auf der ganzen Welt unter Demenz, Alzheimer macht dabei 50-60% aller Demenzfälle aus. Da der Anteil der Bevölkerung, der an Demenz leidet, proportional zum Alter zunimmt und der Anteil älterer Menschen in der Gesellschaft von Jahr zu Jahr steigt, wird Alzheimer immer mehr zu einem ernstzunehmenden, gesellschaftlichen Problem. Zum Stand der heutigen Forschung ist es etabliert, dass die Aminosäure Glutamat - quantitativ einer der wichtigsten Neurotransmitter im Zentralen Nervensystem (ZNS) - toxische Konzentrationen erreichen kann wenn sie - im Zuge der

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7

Pantazis, Konstantinos. "Enterprise Architecture at the Financial Sector with the EAAT Tool." Thesis, KTH, Industriella informations- och styrsystem, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-138610.

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In this Master Thesis an Enterprise Architecture Decision Making analysis is proposed within the field of Enterprise Architecture. A case study at a company within the financial sector has been conducted for validation of the proposed analysis. Firstly, the Enterprise Architecture Analysis Tool (EAAT), which has been developed by the Industrial Information and Control Systems (ICS) department of KTH, is described. This tool has been used during the whole Case Study in order to create present and possible future state models for measuring Service Availability. These models, which are based on a

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8

Seefried, Ulrich [Verfasser]. "Alternatives RNA-Spleißen des Glutamattransporters EAAT2 im ZNS der Maus / Ulrich Seefried." Ulm : Universität Ulm. Medizinische Fakultät, 2001. http://d-nb.info/1015324916/34.

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9

Felbecker, Ansgar [Verfasser]. "Neue 5´-Isoformen des Glutamattransporters EAAT2: RNA-Sequenzen und genomische Organisation / Ansgar Felbecker." Ulm : Universität Ulm. Medizinische Fakultät, 2003. http://d-nb.info/1015438318/34.

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10

Tian, Guilian. "The molecular mechanism of loss of glial glutamate transporter EAAT2 in neurodegenerative disease." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1187038549.

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11

Tian, Guilian. "The molecular mechanisms of the loss of glial glutamate transporter EAAT2 in neurodegenerative diseases." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1187038549.

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12

Leinenweber, Ariane [Verfasser]. "Regulation of Excitatory Amino Acid Transporter 2 (EAAT2) by Carboxy-terminal Domains / Ariane Leinenweber." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2010. http://d-nb.info/100962427X/34.

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13

Mullen, Gary. "Integrating Equine-Assisted Activities and Therapy (EAAT) into a Higher Learning Institution." ScholarWorks, 2010. https://scholarworks.waldenu.edu/dissertations/845.

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Collegiate equestrian programs are costly to operate, and cost often exceeds revenue from tuition. The local problem in this project study was the need for supplemental revenue to support a cost-intensive equestrian program, without cutbacks or raising student fees. The study examined the integration of an equine-assisted activities and therapy (EAAT) program for additional income, while capitalizing on existing institutional resources at a Midwestern university in the United States. Research questions explored how to implement an EAAT program to close the budgetary gap at the project site. Sy

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14

Mavencamp, Terri Lynn. "Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors." The University of Montana, 2009. http://etd.lib.umt.edu/theses/available/etd-03212009-152926/.

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<p>This work describes the synthesis and initial characterization of the biological activity of a family of EAAT3 preferring inhibitors, L-β-benzyl aspartate (L-β-BA) and L-β-BA derivatives. L-β-BA and derivatives were initially synthesized in an approximate 2:1 ratio of diasteromers (threo:erythro), using base promoted enolate addition. Kinetic analysis of 3H-D-aspartate uptake into C17.2 cells expressing the hEAATs demonstrated that L-threo-β-BA is the more potent diastereomer (Ki values of 9 µM for EAAT1, 10.0 µM for EAAT2 and 0.8 µM for EAAT3), acts competitively,

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15

Mavencamp, Terri Lynn. "Design, synthesis and biological evaluation of a family of excitatory amino acid transporter 3 (EAAT3) preferring inhibitors." [Missoula, Mont.] : The University of Montana, 2008. http://etd.lib.umt.edu/theses/available/etd-03212009-152926/unrestricted/Mavencamp_umt_0136D_10009.pdf.

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16

Hotzy, Linda Sabrina Jasmin [Verfasser]. "Fluorometric approaches to analyze the structure-function relationship of excitatory amino acid transporters (EAATs) / Linda Sabrina Jasmin Hotzy." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2013. http://d-nb.info/1032720204/34.

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17

Cao, Jin. "OPERATING SYSTEM SECURITYMODELING : An Experimental Study on the CySeMoL model." Thesis, KTH, Industriella informations- och styrsystem, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-176854.

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In this Master Thesis, several common applications and Windows operating systemservices are modeled within the field of information security. This thesis focuses onapplying the Enterprise Architecture Analysis Tool (EAAT) and the Cyber SecurityModeling Language (CySeMoL), which are developed by the Department of IndustrialInformation and Control System (ICS) at KTH. The overall objective of this study is todetermine the probability of the CySeMol model with a particular kind of attack. Theproject models six common applications on Windows platform and two Windowsoperating system services. The d

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18

Maguire, Jamie Lynn. "The Impact of Glutamate Signaling on Tumor Progression." Diss., Neuroscience Program, George Washington University, 2004. http://hdl.handle.net/1961/121.

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Degree awarded (2004): PhDBmS, Neuroscience Program, George Washington University<br>Glutamate is critically important as an excitatory neurotransmitter in the central nervous system. Increasing evidence suggests additional signaling roles for glutamate in cell proliferation and migration in normal and oncogenic states. Recently, glutamate release from glioma cells has been shown to increase tumor growth in vivo. To investigate the mechanism of glutamate enhancement of tumor growth, we investigated the effect of glutamate on tumor cell proliferation, invasion, and glioma-induced cell death. He

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19

Rabbani, Talvia. "Empirical Testing of the CySeMoL Tool for Cyber Security Assessment – Case Study of Linux Server and MySQL." Thesis, KTH, Skolan för elektro- och systemteknik (EES), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-187664.

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In this Master Thesis, several common applications used with MySQL and Linux server are modelled using the Enterprise Architecture Analysis Tool (EAAT) and the Cyber Security Modelling Language (CySeMoL), both developed by the Department of Industrial Information and Control System (ICS) at KTH. The objective of this study is to use the CySeMoL tool to evaluate the feasibility and correctness of the tool by simulating some particular type of attacks on a real life Linux server. A few common applications with MySQL on a Linux server and two Linux operating system services are modelled and expla

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20

Mekki, Sofiane. "Synthèse de nouveaux dérivés de l'acide β-hydroxyaspartique β-Substitués : inhibiteurs du transport du glutamate dans le Système Nerveux Central (SNC)". Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20079/document.

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Nos travaux ont porté sur la mise au point de synthèse de nouveaux dérivés β-substitués β-hydroxy aspartates : Inhibiteurs du transport du glutamate dans le système nerveux centrale (SNC). Ces analogues d'aspartates ont été caractérisés par différentes méthodes spectroscopiques (RMN-1H, RMN-13C et HRMS) et leur pureté énantiomérique a été confirmée par analyses HPLC chirale et des mesures de pouvoir rotatoire. Ce manuscrit est organisé en trois chapitres : la première partie présente un point bibliographique sur le système glutamatergique dans le SNC, en rappelant les différents récepteurs et

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21

Sirko, Alexandre. "Enterprise Application Modularity : New Features Related to Visualization and Measurement of Modulatity Within the Enterprise Architecture Analysis Tool (EAAT)." Thesis, KTH, Industriella informations- och styrsystem, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-141328.

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During my studies at the Ecole des Mines d'Albi-Carmaux, I did an internship at the Royal Institute of Technology (Kungliga Tekniska Högskolan) in Sweden to finalize my master. The subject of this exercise is positioned as the junction of two different research areas. There is on one hand the development of new analysis method of Enterprise Architecture (EA) and on the other the analysis of software architecture modularity. The entire mission concerns a method of analyzing the modularity of EA developed by Harvard Business School. The analysis method called "Hidden Structure" aims to

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22

Brothers, Holly M. "Neuroinflammation, Glutamate Regulation and Memory." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1363603410.

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23

Frost, Per. "Utvärdering av den upplevda användbarheten hos CySeMoL och EAAT med hjälp av ramverk för ändamålet och ISO/IEC 25010:2011." Thesis, KTH, Industriella informations- och styrsystem, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-138576.

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This report describes a study aimed at uncovering flaws and finding potential improvements from when the modelling tool EAAT is used in conjunction with the modelling language CySeMoL. The study was performed by developing a framework and applying it on CySeMoL and EAAT in real life context networks. The framework was developed in order to increase the number of flaws uncovered as well as gather potential improvements to both EAAT and CySeMoL. The basis of the framework is a modified version of the Quality in use model from ISO/IEC 25010:2011 standard. Upon the characteristics and sub characte

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24

Dalet, Antoine. "Homéostasie glutamatergique des synapses en calice de l’appareil vestibulaire : implication de plusieurs transporteurs du glutamate de la famille des EAAT." Thesis, Montpellier 2, 2011. http://www.theses.fr/2011MON20115/document.

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L'homéostasie glutamatergique dans les fentes synaptiques régule la neurotransmission et préserve de l'excitotoxicité. Cela est particulièrement important dans l'oreille interne où il y a une libération soutenue de neurotransmetteur. Pour la plupart des cellules ciliées cochléaires et vestibulaires, la clairance du glutamate est assurée par les transporteurs du glutamate EAAT1 (GLAST) exprimés par les cellules de soutien. Un tel mécanisme n'est pas possible pour les cellules ciliées vestibulaires de type I car leur terminaison synaptique en calice empêche tout accès à la fente synaptique. Nous

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25

Westerberg, Per. "Enterprise Architecture Analysis : - Astudy of the IT landscape atAstraZeneca." Thesis, KTH, Industriella informations- och styrsystem, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-169227.

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A case study at a global pharmaceutical company has been conducted toanalyse how the Hidden Structure method using the Enterprise Architecture Analyses(EAAT) tool, developed at KTH, can be used to visualize the IT architecture and tocreate a better understanding on which applications could increase a risk of therobustness of the architecture if changes was done to them. Also the measure of ITsupport metrics as incidents and changes per system has been analysed to understandif they can be used to understand the robustness of the incident. The tool was used tocreate a model of the enterprise arc

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26

Sreemantula, Sai Nandini. "Glutamate Transporter 1 in the Central Nervous System: Potential Target for the Treatment of Alcohol Dependence." University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1333546775.

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27

Roman, Kenny M. "GLT-1 over-expression attenuates visceral nociception by pharmacological and gene therapy approaches." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1332424243.

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28

Rosell, Peter. "Enterprise Architecture Modeling of Core Administrative Systems at KTH : A Modifiability Analysis." Thesis, KTH, Industriella informations- och styrsystem, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-99166.

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This project presents a case study of modifiability analysis on the Information Systems which are central to the core business processes of Royal Institution of Technology in Stockholm, Sweden by creating, updating and using models. The case study was limited to modifiability regarding only specified Information Systems. The method selected was Enterprise Architecture together with Enterprise Architecture Analysis research results and tools from the Industrial Information and Control Systems department of the same University. Jointly used with the ArchiMate modelling language, to create the mo

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29

Foster, Joshua B. "Development of Pyridazine-Derivatives for the Treatment of Neurological Disorders." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1545904228813231.

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30

Johansson, Dan. "Empirical test of a tool for cyber security vulnerability assessment." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-176032.

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This report describes a study aimed at verifying a cyber security modeling language named the Predictive, Probabilistic Cyber Security Modelling Language. This modeling language together with the Enterprise Architecture Analysis Tool acts as a tool for cyber security evaluations of system architectures. To verify the accuracy and readiness of the tool, a generic model of a real life Supervisory Control And Data Acquisition System’s system architecture was modeled using the tool and later evaluated. The evaluation process consisted of a Turing test, which was the same method used for evaluation

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31

Munger, Emily LaRee. "Alteration to Astrocyte Density and Morphology across Mammalia with Specific Attention to Primate Brain Evolution and Aging." Kent State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=kent1594638449298271.

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32

Kim, Seol-Hee. "Acetaminophen Associated Neurotoxicity and its Relevance to Neurodevelopmental Disorders." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6717.

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Autism is a lifelong neurodevelopmental disorder. The etiology of autism still remains unclear due to the heterogeneous and complex nature of the disorder, however synergistic actions between genetic components and environmental factors have been suggested. Acetaminophen (APAP) is one of the most popular over-the-counter drugs that possess antipyretic and analgesic effects. It is considered a relatively safe and effective within therapeutic doses. Recently, early exposure to APAP has been suggested to be one of the underlying cause of autism. Children are often prescribed APAP to lessen fever

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33

Sopjani, Mentor [Verfasser]. "The AMP activated protein kinase in the regulation of sodium coupled transporters (SGLT1, EAAT3 & EAAT4) and eryptosis / von Mentor Sopjani." 2010. http://d-nb.info/100125581X/34.

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34

Melzer, Nico [Verfasser]. "Der Anionenkanal des neuronalen Glutamattransporters EAAT4 / vorgelegt von Nico Melzer." 2006. http://d-nb.info/98360004X/34.

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35

Schniepp, Roman [Verfasser]. "Regulation der exzitatorischen Aminosäure-Transporter EAAT1, EAAT2, EAAT3 und EAAT5 durch die Serum- und Glukokortikoid-abhängige Kinase SGK und die Ubiquitinligase Nedd4-2 / vorgelegt von Roman Schniepp." 2006. http://d-nb.info/98366790X/34.

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36

Weiss, Thorsten [Verfasser]. "Das Expressionsverhalten der glialen Glutamattransporter EAAT1 und EAAT2 sowie von PACAP nach Schädel-Hirntrauma des Menschen / von Thorsten Weiss." 2006. http://d-nb.info/981850995/34.

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37

Yi, Jae-Hyuk. "Les mécanismes excitotoxiques et le rôle de transporteurs de glutamate dans la physiopathologie des traumatismes crâniens = Excitotoxic mechanisms and the role of glutamate transporters in the pathophysiology of traumatic brain injury." Thèse, 2006. http://hdl.handle.net/1866/15364.

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38

Kim, Helena J. "Effects of long-term inhibition of EAAT2 on the excitability of spinal dorsal horn neurons." Master's thesis, 2010. http://hdl.handle.net/10048/1619.

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This thesis examined the effects of long-term inhibition of excitatory amino acid transporter 2 (EAAT2) on the excitability of dorsal horn neurons in defined-medium organotypic slice cultures (DMOTCs). Previous reports suggest that inhibition of EAAT2 may be involved in development of neuropathic pain induced by brain-derived neurotrophic factor (BDNF). Experiments were carried out using confocal Ca2+ imaging to assess the excitability of dorsal horn neurons. Long-term treatment with EAAT2 blocker, dihydrokainate (DHK), prominently increased the neuronal excitability. Long-term exposure to DH

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39

Pannunzio, Marc. "Effets du cuivre (II) sur le transport à haute affinité du glutamate dans des astrocytes en culture : proposition d'un mécanisme physiopathologique de la maladie de Wilson." Thèse, 2003. http://hdl.handle.net/1866/14883.

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40

Fromm, Andrea Heike Lydia [Verfasser]. "Mutationsscreening und alternative Spleivarianten des Glutamattransporters EAAT2 bei amyotropher Lateralsklerose / vorgelegt von Andrea Heike Lydia Fromm." 2008. http://d-nb.info/100069450X/34.

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41

"Design, synthesis and biological evaluation of a family of excitatory amino acid transporter 3 (EAAT3) preferring inhibitors." UNIVERSITY OF MONTANA, 2009. http://pqdtopen.proquest.com/#viewpdf?dispub=3338786.

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42

Chawla, Aarti R. "CaMKII regulation of astrocytic glutamate uptake." Diss., 2016. http://hdl.handle.net/1805/10605.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Glutamate clearance by astrocytes is an essential part of physiological excitatory neurotransmission. Failure to adapt or maintain low levels of glutamate in the central nervous system is associated with multiple acute and chronic neurodegenerative diseases. The primary excitatory amino acid transporters (EAATs) in human astrocytes are EAAT1 and EAAT2 (GLAST and GLT-1 respectively in rodents). While the inhibition of a ubiquitously-expressed serine/threonine protein kinase, the calcium/calmodulindependent kinase (CaMKII) result

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43

Ugbode, Christopher I., W. D. Hirst, and Marcus Rattray. "Neuronal influences are necessary to produce mitochondrial co-localization with glutamate transporters in astrocytes." 2014. http://hdl.handle.net/10454/7811.

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yes<br>Abstract Recent evidence suggests that the predominant astrocyte glutamate transporter, GLT-1/ Excitatory Amino Acid Transporter 2 (EAAT2) is associated with mitochondria. We used primary cultures of mouse astrocytes to assess co-localization of GLT-1 with mitochondria, and tested whether the interaction was dependent on neurons, actin polymerization or the kinesin adaptor, TRAK2. Mouse primary astrocytes were transfected with constructs expressing V5-tagged GLT-1, pDsRed1-Mito with and without dominant negative TRAK2. Astrocytes were visualized using confocal microscopy and c

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Ugbode, Christopher I., W. D. Hirst, and Marcus Rattray. "Astrocytes grown in Alvetex® 3 dimensional scaffolds retain a non-reactive phenotype." 2015. http://hdl.handle.net/10454/8062.

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yes<br>Protocols which permit the extraction of primary astrocytes from either embryonic or postnatal mice are well established however astrocytes in culture are different to those in the mature CNS. Three dimensional (3D) cultures, using a variety of scaffolds may enable better phenotypic properties to be developed in culture. We present data from embryonic (E15) and postnatal (P4) murine primary cortical astrocytes grown on coated coverslips or a 3D polystyrene scaffold, Alvetex. Growth of both embryonic and postnatal primary astrocytes in the 3D scaffold changed astrocyte morphology to a m

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45

Carbone, M., S. Duty, and Marcus Rattray. "Riluzole neuroprotection in a parkinson’s disease model involves suppression of reactive astrocytosis but not GLT-1 regulation." 2012. http://hdl.handle.net/10454/7807.

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yes<br>Background: Riluzole is a neuroprotective drug used in the treatment of motor neurone disease. Recent evidence suggests that riluzole can up-regulate the expression and activity of the astrocyte glutamate transporter, GLT-1. Given that regulation of glutamate transport is predicted to be neuroprotective in Parkinson’s disease, we tested the effect of riluzole in parkinsonian rats which had received a unilateral 6-hydroxydopamine injection into the median forebrain bundle. Results: Rats were treated with intraperitoneal riluzole (4 mg/kg or 8 mg/kg), 1 hour before the lesion then on

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46

Peng, Jhan-Jie, and 彭湛傑. "Investigate roles of Drosophila Eaat1-mediated glutamate clearance in the functional integrity of the motor circuit and the formation of the neuromuscular junction." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/02184445433768124130.

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碩士<br>國立臺灣大學<br>生化科學研究所<br>104<br>Glutamate transmission in CNS is critical for animal behavior. Upon the release of glutamate from synaptic vesicles, it is immediately removed by the surrounding astrocyte. The Excitatory Amino Acid Transporter (Eaat) in astrocyte is majorly responsible for the glutamate clearance in CNS, which ensures the fidelity of neurotransmission and prevents glutamate excitotoxicity. In neurodegenerative diseases, downregulation of Eaat has been repeatedly reported and accumulation of extracellular glutamate due to impaired recycle system accelerates the disease progres

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47

Winterberg, Markus [Verfasser]. "Der humane Transporter EAAT 3 ist ein Kandidat für die Vermittlung der L-Glutamat-Aufnahme in Plasmodium-falciparum-infizierte Erythrozyten / vorgelegt von Markus Winterberg." 2009. http://d-nb.info/99588112X/34.

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48

Carbone, M., S. Duty, and Marcus Rattray. "Riluzole elevates GLT-1 activity and levels in striatal astrocytes." 2012. http://hdl.handle.net/10454/5907.

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Drugs which upregulate astrocyte glutamate transport may be useful neuroprotective compounds by preventing excitotoxicity. We set up a new system to identify potential neuroprotective drugs which act through GLT-1. Primary mouse striatal astrocytes grown in the presence of the growth-factor supplement G5 express high levels of the functional glutamate transporter, GLT-1 (also known as EAAT2) as assessed by Western blotting and (3)H-glutamate uptake assay, and levels decline following growth factor withdrawal. The GLT-1 transcriptional enhancer dexamethasone (0.1 or 1 muM) was able to prevent l

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