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Journal articles on the topic 'Ear edema'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Ferreira, Everton Allan, Lucas Sales Queiroz, Gabriella de Faria Silva Facchini, et al. "Baccharis dracunculifolia DC (Asteraceae) Root Extract and Its Triterpene Baccharis Oxide Display Topical Anti-Inflammatory Effects on Different Mice Ear Edema Models." Evidence-Based Complementary and Alternative Medicine 2023 (May 25, 2023): 1–10. http://dx.doi.org/10.1155/2023/9923941.

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B. dracunculifolia is popularly used to treat skin diseases. This work aimed to evaluate the topical anti-inflammatory properties of B. dracunculifolia root extract (BdR) and its major compound baccharis oxide (BOx) on mice ear edema models. BdR was analyzed by GC-MS, and BOx was isolated by chromatographic fractionation. Topical anti-inflammatory activities were determined by using the croton oil, capsaicin, histamine, and phenol-induced mouse ear edema models. N-acetyl-β-D- glucosaminidase (NAG) and myeloperoxidase (MPO) activities, as well as NO dosage and histopathological analyses, were a

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2

Fachini-Queiroz, Fernanda Carolina, Raquel Kummer, Camila Fernanda Estevão-Silva, et al. "Effects of Thymol and Carvacrol, Constituents ofThymus vulgarisL. Essential Oil, on the Inflammatory Response." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/657026.

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Thyme (Thymus vulgarisL., Lamiaceae) is an aromatic and medicinal plant that has been used in folk medicine, phytopharmaceutical preparations, food preservatives, and as an aromatic ingredient. The effect ofThymus vulgarisessential oil (TEO) and its isolated constituents thymol and cavacrol (CVL) were studied in the following experimental models: ear edema, carrageenan-induced pleurisy, and chemotaxisin vitro. In the pleurisy model, TEO, CVL, and thymol significantly inhibited inflammatory edema. However, only TEO and CVL inhibited leukocyte migration. In thein vitrochemotaxis experiment, CVL

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3

Li, Dongli, Xiaodan Tang, Chang Liu, et al. "Jasmine (Jasminum grandiflorum) Flower Extracts Ameliorate Tetradecanoylphorbol Acetate Induced Ear Edema in Mice." Natural Product Communications 15, no. 4 (2020): 1934578X2091749. http://dx.doi.org/10.1177/1934578x20917498.

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Published data from in vitro assays support the anti-inflammatory effects of jasmine ( Jasminum grandiflorum Linn.) but limited studies are reported in animal models. Herein, the anti-inflammatory effects of jasmine flower extracts (JFEs) including ethanol extract (JF-EE), petroleum ether extract (JF-PEE), ethyl acetate extract (JF-EAE), and n-butanol extract (JF-BE) were evaluated in a mouse ear edema model. Acute mouse ear skin inflammation was induced by tetradecanoylphorbol acetate (TPA; 125 µg/mL) and then treated with JFEs (100 mg/mL) or dexamethasone (DEX; 6.25 mg/mL; as a positive cont

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4

Li, Zhuocheng, Lei Zhang, and Zhichao Zhao. "Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation." Pain Research and Management 2021 (June 18, 2021): 1–9. http://dx.doi.org/10.1155/2021/4919391.

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Objective. Inflammation and pain are involved in the pathophysiology of various clinical conditions. This investigation aims to probe the analgesic and anti-inflammatory activity of Maltoamide F. Methods. The possible toxicity of Maltoamide F was evaluated by an acute toxicity test. To assess the anti-inflammatory and antinociceptive effects of Maltoamide F on rats, the models of carrageenan-caused paw edema, xylene-induced ear edema, arachidonic-acid- (AA-) induced ear edema, formalin-caused plantar edema, and cotton-pellet-induced granuloma were established. Levels of TNF-α, PGE-2, and IL-6

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5

Mokhnache, Kamel, Ahlem Karbab, Soraya Madoui, et al. "Topical Anti-inflammatory evaluation of new hydrazone: 4-chloro-3-nitrobenzylidene) isonicotinohydrazide." Journal of Drug Delivery and Therapeutics 9, no. 5-s (2019): 1–3. http://dx.doi.org/10.22270/jddt.v9i5-s.3433.

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The anti-inflammatory effects of the investigated compounds; Isoniazid, hydrazone, and Indomethacin were evaluated in this study. The experiment was performed using xylene induced topical ear edema method in mice model, at the dose of (0.5 mg/ear). Results showed that the compounds; Isoniazid, hydrazone, and Indomethacin exerted 85, 90 and 89% of inhibition percentages, respectively. The effect of hydrazone was statistically similar to the effect of indomethacin which is a standard anti-inflammatory drug. Keywords: inflammation, hydrazone, ear edema, topical.

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6

Pranaya, G., P. Venkata Smitha, N. Srinivasa Reddy, R. Vinay, Ch Murali Mohan, and Akondi Butchi Raju. "Evaluation of Analgesic and Anti-Inflamatory Activity of Ventilago calyculata." International Journal of Life Sciences 9, no. 1 (2015): 43–47. http://dx.doi.org/10.3126/ijls.v9i1.11925.

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Ventilago calyculata was traditionally used to treat sprains and pain. The purpose of this study was to evaluate the analgesic and anti-inflammatory activity of methanolic extract of bark of Ventilago calyculata (MVC). For evaluating analgesic activity, Hot plate method, Tail-flick method, Formalin test and Writhing methods were used. For evaluating anti-inflammatory activity Carrageenan induced paw edema and Xylene induced ear edema methods were used. Administration of MVC (100 and 200mg/kg) significantly reduced the total number of writhings in Acetic acid induced writhing method. In Hot pla

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7

Olumoh-Abdul, Hidayah Ayodeji, Rashidat Oluwafunke Ayanniyi, Fatimoh Idowu Ojuade, and Remilekun Justina Agbana. "Evaluation of Nutraceutical content and topical Anti-inflammatory Activities of Turraea vogelii Hook F. Ex Benth (Meliaceae)." Iranian Journal of Toxicology 13, no. 1 (2019): 35–39. http://dx.doi.org/10.32598/ijt.13.1.561.1.

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Background: Turraea vogelii has been used as traditional medicine for the treatment of ailments including wounds, stomach aches, malaria, infections, filariasis cutaneous, among others and, it serves as source of food. The present study aimed to evaluate the nutraceuticals content and topical anti-inflammatory effect of hydro-methanol twig extract of Turraea vogelii (METV). Method: METV was obtained using cold maceration with water and methanol in ratio 30:70. The concentration of vitamins A, C and E, total phenolic and total flavonoid contents were evaluated by UV spectrophotometric method. P

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8

Prieto, J. M., M. C. Recio, R. M. Giner, et al. "Topical Anti-Inflammatory Lignans from Haplophyllum hispanicum Haplophyllum hispanicum." Zeitschrift für Naturforschung C 51, no. 9-10 (1996): 618–22. http://dx.doi.org/10.1515/znc-1996-9-1002.

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The present paper reports the results of the methanol extract of Haplophyllum hispanicum Spach on single or repeated local 12-O-tetradecanoylphorbol acetate (TPA) administration and in the oxazolone-induced contact-delayed hypersensitivity mouse ear edemas. Two topical anti-inflammatory aryl naphthalide lignans were isolated from the active fractions of the methanol extract. They were identified by spectroscopic methods, including 13C NMR and heteronuclear multiple bond correlation (HMBC), as diphyllin acetyl apioside and tuberculatin. The former was the most active on acute TPA edema with a I

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9

Okorie, Augustine Nkemakolam, and Kelechi Martins Nworie. "Phytochemical Screening and Anti-Inflammatory Activities of Methanolic Leaf Extract of Bauhinia monandra in Animal Models." International Journal of Pharmacology, Phytochemistry and Ethnomedicine 11 (October 2018): 7–16. http://dx.doi.org/10.18052/www.scipress.com/ijppe.11.7.

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The leaves of Bauhinia monandra prepared as poultices are used in many Brazilian tribes and some Nigerian communities to relieve swelling and pains, arthritis, diabetes among other ailments. These folkloric claimed benefits inspired this study in which topical and systemic anti-inflammatory activities of a methanol extract of B. monandra leaves (MEBmL) was assessed in rodents. The anti-inflammatory activities of B. monandra were determined by egg albumin-induced (systemic) paw edema in rats, and xylene-induced (topical) ear edema in mice. Treatment of rats with MEBmL at different concentration

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10

Laranjeira, Inês Martins, João N. D. Gonçalves, Cátia Gonçalves, et al. "Anti-Inflammatory Effect of Pterospartum tridentatum Leaf Extract in Acute and Chronic Inflammation." Applied Sciences 13, no. 7 (2023): 4494. http://dx.doi.org/10.3390/app13074494.

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Pterospartum tridendatum is an important source of active compounds with anti-inflammatory properties. The ability of P. tridentatum leaves methanolic extract in preventing/reversing inflammation was studied in adult rats using a model of experimental osteoarthritis (OA) and ear edema. Control animals (SHAM) were administered phosphate buffer solution (PBS), while OA animals received either P. tridentatum 100 mg/kg, 300 mg/kg, or a commercial anti-inflammatory (15 mg/Kg, Ibuprofen) via gavage, daily, for three weeks. Ear edema was induced, and the animals were divided into five groups treated

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11

Paniagua-Pérez, Rogelio, Laura Sánchez-Chapul, Eduardo Madrigal-Bujaidar, et al. "Anti-Inflammatory Potential of Pteropodine in Rodents." Metabolites 13, no. 8 (2023): 907. http://dx.doi.org/10.3390/metabo13080907.

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Pteropodine (PT) is a component of some plants with potentially useful pharmacological activities for humans. This compound has biomedical properties related to the modulation of the immune system, nervous system, and inflammatory processes. This study addresses the anti-inflammatory and antioxidant capacity of pteropodin in a murine model of arthritis and induced edema of the mouse ear. To evaluate the anti-inflammatory activity, we used the reversed passive Arthus reaction (RPAR), which includes the rat paw edema test, the rat pleurisy test, and a mouse ear edema model. The antioxidant effec

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12

Bustos-Salgado, Paola, María J. Rodríguez-Lagunas, Valeri Domínguez-Villegas, Berenice Andrade-Carrera, Ana Calpena-Campmany, and María Luisa Garduño-Ramírez. "Ex Vivo and In Vivo Anti-inflammatory Evaluations of Modulated Flavanones Solutions." Proceedings 78, no. 1 (2020): 23. http://dx.doi.org/10.3390/iecp2020-08657.

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Interest has developed in natural molecules due to their clinically proven effects on skin diseases. Flavanones display several biological activities, and recently have been the focus of studies due to their anti-inflammatory effect. To improve their pharmacological profile, four flavanones (A, B, C, and D) were synthesized by structural modification of one natural flavanone 1 (semi-systematic name: (2S)-5,7-dihydroxy-6-prenylflavanone) extracted from Eysenhardtia platycarpa. The hydroalcoholic flavanone solutions (FS) were assayed to investigate their anti-inflammatory effect on two in vivo c

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13

Piana, Mariana, Camila Camponogara, Aline Augusti Boligon, and Sara Marchesan Oliveira. "Solanum paranenseExtracts and Solanine Present Anti-Inflammatory Activity in an Acute Skin Inflammation Model in Mice." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/4295680.

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The aim of the study was to evaluate the anti-inflammatory activity of theS. paranensecrude extract,S. paranensealkaloid fraction, and solanine alkaloid. These samples reduce the croton oil-induced ear edema in a dose-dependent manner and a maximum inhibition of 81%, 98%, and 80% in the doses of 1.0, 0.73, and 0.37 mg/ear, respectively. Moreover, the samples inhibit the MPO activity with an inhibition maximum of 51%, 40%, and 46% in the doses of 1.0, 0.73, and 0.37 mg/ear, respectively. Similar results were found for dexamethasone 0.10 mg/ear (positive control), which showed inhibitions of ear

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14

Sireeratawong, Seewaboon, Kanjana Jaijoy, Parirat Khonsung, and Noppamas Soonthornchareonnon. "ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE WATER EXTRACT FROM TERMINALIA CHEBULA REZT." African Journal of Traditional, Complementary and Alternative Medicines 11, no. 6 (2014): 77–82. http://dx.doi.org/10.21010/ajtcam.v11i6.8.

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Background: In ayurvedic and Thai traditional medicine, the fruit of T. chebula is useful in arthritic disorders, inflammation, tumor, pains, chronic and recurrent fever. The study investigated the analgesic and anti-inflammatory activities in animal models. Materials and methods: The water extract of T. chebula fruit was prepared and pain induced in mice by 0.1% formalin, before testing for the analgesic activity of the extract. The anti-inflammatory study was conducted in rats using four experimental models; ethyl phenylpropiolate or arachidonic acid-induced ear edema, carrageenan-indu

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15

Li, Li, Yuzhen Li, Liping Ding, and Zhong Huang. "Effect of Incarvillea caffeate on mouse ear edema." Journal of Shenzhen University Science and Engineering 34, no. 1 (2017): 46. http://dx.doi.org/10.3724/sp.j.1249.2017.01046.

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16

Kim, Hee Kee, Soon Young Namgoong, and Hyun Pyo Kim. "Antiinflammatory activity of flavonoids: Mouse ear edema inhibition." Archives of Pharmacal Research 16, no. 1 (1993): 18–24. http://dx.doi.org/10.1007/bf02974122.

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17

Cui, Yongming, Mingzhang Ao, Jing Hu, and Longjiang Yu. "Anti-Inflammatory Activity of Licochalcone A Isolated from Glycyrrhiza inflata." Zeitschrift für Naturforschung C 63, no. 5-6 (2008): 361–65. http://dx.doi.org/10.1515/znc-2008-5-609.

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Licochalcone A was isolated from the roots of Glycyrrhiza inflata and evaluated for its anti-inflammatory activity in xylene-induced mice ear edema and carrageenan-induced paw edema tests. At the same time, the inhibition of prostaglandin biosynthesis by licochalcone A was also studied in lipopolysaccharide (LPS)-induced mouse macrophage cells. At 5 mg/ ear, licochalcone A showed remarkable effects against acute inflammation induced by xylene, and at the doses of 2.5, 5, 10 mg/kg (p.o.), licochalcone A reduced significantly paw edema induced by carrageenan compared to the control at the fourth

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18

Singsai, Kanathip, Pimchanok Charoongchit, Waritsara Chaikaew, Nirut Boonma, Pitsinee Fhanjaksai, and Karitta Chaisatan. "Antilipoxygenase and Anti-Inflammatory Activities of Streblus asper Leaf Extract on Xylene-Induced Ear Edema in Mice." Advances in Pharmacological and Pharmaceutical Sciences 2020 (December 5, 2020): 1–5. http://dx.doi.org/10.1155/2020/3176391.

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Streblus asper (SA) belonging to the Moraceae family is well known as a folk medicinal plant in Asian countries. This study aimed to investigate the antilipoxygenase activity and the anti-inflammatory effects of the SA leaf extract. An in vitro antilipoxygenase study was performed using a lipoxygenase assay, and the oxidation of linoleic acid into 13-hydroperoxy linoleic acid (HPODE) was detected with a UV spectrophotometer at a wavelength of 234 nm. In the animal study, twenty-five male ICR mice were induced as ear edema by topical xylene, and the ear thickness of the mice was measured. The l

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19

Hanprasertpong, Nutthiya, Supanimit Teekachunhatean, Rujirek Chaiwongsa, et al. "Analgesic, Anti-Inflammatory, and Chondroprotective Activities ofCryptolepis buchananiExtract:In VitroandIn VivoStudies." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/978582.

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Cryptolepis buchananiRoem. & Schult. is widely used in folk medicine in Southeast Asia for treating muscle tension and arthritis. This study aimed to investigate an analgesic activity of the methanol extract ofC. buchanani(CBE) in acetic acid-induced writhing response in mice, and to examine its anti-inflammatory activity in ethyl phenylpropiolate- (EPP-) induced ear edema and carrageenan-induced paw edema in rats. Its effects on cartilage degradation induced by interleukin-1β(IL-1β) in porcine cartilage explant culture were also determined. This study demonstrated that CBE significantly r

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20

Li, Chu-Wen, Xiao-Li Wu, Xiao-Ning Zhao, et al. "Anti-Inflammatory Property of the Ethanol Extract of the Root and Rhizome ofPogostemon cablin(Blanco) Benth." Scientific World Journal 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/434151.

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The aim of this study was to investigate the anti-inflammatory property of the ethanol extract of the root and rhizome ofPogostemon cablin(ERP). The anti-inflammatory effect was evaluated using four animal models including xylene-induced mouse ear edema, acetic acid-induced mouse vascular permeability, carrageenan-induced mouse pleurisy, and carrageenan-induced mouse hind paw edema. Results indicated that oral administration of ERP (120, 240, and 480 mg/kg) significantly attenuated xylene-induced ear edema, decreased acetic acid-induced capillary permeability, inhibited carrageenan-induced neu

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21

Na Takuathung, Mingkwan, Kanjana Jaijoy, Noppamas Soonthornchareonnon, and Seewaboon Sireeratawong. "Anti-inflammatory, Antinociceptive, and Antitumorigenesis Activities of Terminalia Bellerica (Gaertn.) Roxb. in Animal Models." Natural Product Communications 17, no. 4 (2022): 1934578X2210899. http://dx.doi.org/10.1177/1934578x221089996.

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Previous pharmacological research has demonstrated that Terminalia bellerica (Gaertn.) Roxb. (TB) extract possesses several pharmacological activities. However, there is scant evidence documenting the therapeutic activities of TB extract on inflammation, pain, and cancers. Our study examined the in vivo anti-inflammation, antinociception, and antitumorigenesis effects of TB extract and investigated possible mechanisms for those effects. Anti-inflammation activities of TB extract were evaluated using ethyl phenylpropiolate (EPP)- and arachidonic acid (AA)-induced ear edema models, a cotton pell

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22

Maxia, Andrea, Maria Assunta Frau, Danilo Falconieri, Manvendra Singh Karchuli та Sanjay Kasture. "Essential Oil of Myrtus communis Inhibits Inflammation in Rats by Reducing Serum IL-6 and TNF-α". Natural Product Communications 6, № 10 (2011): 1934578X1100601. http://dx.doi.org/10.1177/1934578x1100601034.

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The topical anti-inflammatory activity of the essential oil of Myrtus communis L. was studied using croton oil induced ear edema and myeloperoxidase (MPO) activity in mice, and cotton pellet induced granuloma, and serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in rats. On topical application, the oil exhibited a significant decrease in the ear edema as well as MPO activity. The oil also inhibited cotton pellet-induced granuloma and serum TNF-α and IL-6. It can be concluded that the essential oil of Myrtus communis reduces leukocyte migration to the damaged tissue and exhibits a

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23

Cardia, Gabriel Fernando Esteves, Saulo Euclides Silva-Filho, Expedito Leite Silva, et al. "Effect of Lavender (Lavandula angustifolia) Essential Oil on Acute Inflammatory Response." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/1413940.

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Lavandula angustifolia is a plant of Lamiaceae family, with many therapeutic properties and biological activities, such as anticonvulsant, anxiolytic, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of this study was to evaluate the effect of Lavandula angustifolia Mill. essential oil (LEO) on acute inflammatory response. LEO was analyzed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR) methods and showed predominance of 1,8-cineole (39.83%), borneol (22.63%), and camphor (22.12%). LEO at concentrations of 0.5, 1, 3, and

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Cabrini, Daniela Almeida, Henrique Hunger Moresco, Priscila Imazu, et al. "Analysis of the Potential Topical Anti-Inflammatory Activity ofAverrhoa carambolaL. in Mice." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–7. http://dx.doi.org/10.1093/ecam/neq026.

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Inflammatory skin disorders, such as psoriasis and atopic dermatitis, are very common in the population; however, the treatments currently available are not well tolerated and are often ineffective.Averrhoa carambolaL. (Oxalidaceae) is an Asian tree that has been used in traditional folk medicine in the treatment of several skin disorders. The present study evaluates the topical anti-inflammatory effects of the crude ethanolic extract ofA. carambolaleaves, its hexane, ethyl acetate, and butanol fractions and two isolated flavonoids on skin inflammation. Anti-inflammatory activity was measured

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Aitbaba, Abdelfatah, Zahra Sokar, and Abderrahman Chait. "Analgesic and anti-inflammatory effects of hydroalcoholic extract of Astragalus ibrahimianus." Bangladesh Journal of Pharmacology 18, no. 2 (2023): 41–48. https://doi.org/10.3329/bjp.v18i2.65135.

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This study aims to investigate the analgesic, anti-inflammatory, and antioxidant effects of the hydroalcoholic extract of Astragalus ibrahimianus, an endemic plant of Morocco. The analgesic effect was tested using the hot plate, writhing, and formalin tests. The anti-inflammatory activity was assessed by carrageenan and xylene-induced paw/ear edema respectively. The antioxidant activity was evaluated by three tests, namely DPPH, reducing power, and iron chelation. A. ibrahimianus treatment resulted in a significant reduction in carrageenan-induced paw edema and xylene-induced ear edema. Acute

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Tatli, I. Irem, Zeliha S. Akdemir, Erdem Yesilada, and Esra Küpeli. "Anti-Inflammatory and Antinociceptive Potential of Major Phenolics from Verbascum salviifolium Boiss." Zeitschrift für Naturforschung C 63, no. 3-4 (2008): 196–202. http://dx.doi.org/10.1515/znc-2008-3-406.

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The potential effects of flavonoids, phenylethanoid and neolignan glycosides from the aerial parts of Verbascum salviifolium Boiss. were studied in the p-benzoquinone-induced writhing reflex, for the assessment of the antinociceptive activity, and in carrageenan- and PGE1- induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced ear edema models in mice, for the assessment of the anti-inflammatory activity. Through bioassay-guided fractionation and isolation procedures ten compounds from the aqueous extract of the plant, luteolin 7-O-glucoside (1), luteolin 3′-O-glucoside (2), ap

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Sharar, S. R., D. D. Mihelcic, K. T. Han, J. M. Harlan, and R. K. Winn. "Ischemia reperfusion injury in the rabbit ear is reduced by both immediate and delayed CD18 leukocyte adherence blockade." Journal of Immunology 153, no. 5 (1994): 2234–38. http://dx.doi.org/10.4049/jimmunol.153.5.2234.

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Abstract mAb blockade of CD18-mediated neutrophil adherence has previously been shown to reduce tissue injury in the rabbit ear as a result of ischemia followed by reperfusion. Similar injury reduction has been demonstrated whether treatment is given before ischemia or at the time of reperfusion. We examined the effects of delayed treatment with blocking CD18 mAb (60.3) after reperfusion of ischemic rabbit ears. The central neurovascular bundle of rabbit ears was isolated by microsurgery, the remainder of the ear devascularized, and all nerves cut to render the ear anesthetic. Arterial blood f

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Innocent O Ajawobu, Chika C Abba, Ogechi O Anyanwu, Chukwubuikem C Okolo, Paul Chinwuba, and Festus BC. Okoye. "Investigation of the chemical composition and anti-inflammatory effects of the crude methanolic extract and fractions of Artocarpus heterophyllus (Fam. Moraceae)." Magna Scientia Advanced Research and Reviews 8, no. 2 (2023): 075–83. http://dx.doi.org/10.30574/msarr.2023.8.2.0107.

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Inflammation is a local response of living tissues in mammals towards injury and is normally linked to the pathogenesis of several diseases. In this study, we investigated the anti-inflammatory activity of the methanol extract and the n-hexane, ethyl acetate and butanol fractions of the Jack fruit leaves. Methanolic cold maceration was carried out to get the extract, followed by liquid-liquid fractionation. Two models, viz. xylene-induced ear edema in mice and egg albumin-induced paw edema in rats were used to evaluate them. The anti-inflammatory activity of the extract and fractions was scree

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Emrizal, Farediah Ahmad, Hasnah M. Sirat, et al. "Anti-inflammatory Activity of Piper Magnibaccum (Piperaceae)." Natural Product Communications 3, no. 10 (2008): 1934578X0800301. http://dx.doi.org/10.1177/1934578x0800301028.

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Anti-inflammatory activity of a crude extract of Piper magnibaccum (Piperaceae) and of compounds isolated from it was established using the TPA-induced mouse ear edema model and an in vitro quantitative lipoxygenase inhibition assay. Five compounds were isolated from P. magnibaccum [β-sitosterol, N-isobutyl-(2 E,4 E)-tetradecadienamide, linoleic acid, 13-(4′, 5′-dimethoxytridecanoyl)piperidine, and piperine]. The light petroleum extract of the plant exhibited significant anti-inflammatory activity in both models. N-isobutyl-(2 E,4 E)-tetradecadienamide showed significant activity, with an IE %

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Chandran, Jayanthy, Ranjith Vimalraj .T, Pothiappan.P, Vijayakumar.H, Rajat Sagare, and Kavitha S. "Juvenile Cellulitis in a Labrador retriever- A case report." Indian Journal of Veterinary Medicine 44, no. 1 (2024): 32–35. http://dx.doi.org/10.56093/ijvm.v44i1.151776.

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A labrador retriever pup aged 50 days was brought to Madras Veterinary College Small animal outpatient Unit with a history of anorexia, pyrexia, dullness with papules and pustules over muzzle and ear pinnae since three days. Facial edema, periocular edema and enlargement of pre scapular and submandibular lymphnodes were noticed on clinical examination. After complete physical examination, blood samples, skin scrapings, samples for bacterial culture and cytology were taken. Hemogram revealed anemia, serum biochemistry revealed low serum total protein concentration, skin scrapings were negative

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Menezes, Hércules, José Alvarez, and Eduardo Almeidaa. "Mouse Ear Edema Modulation by Different Propolis Ethanol Extracts." Arzneimittelforschung 49, no. 08 (2011): 705–7. http://dx.doi.org/10.1055/s-0031-1300486.

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Inoue, Hideo, Nobuyuki Nagata, and Yasuko Koshihara. "Participation of Serotonin in Capsaicin-Induced Mouse Ear Edema." Japanese Journal of Pharmacology 69, no. 1 (1995): 61–68. http://dx.doi.org/10.1254/jjp.69.61.

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33

Cui, Enhui, Xiaoyan Zhi, Ying Chen, et al. "Coptis chinensisand Myrobalan (Terminalia chebula) Can Synergistically Inhibit Inflammatory Response In Vitro and In Vivo." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/510157.

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Objectives. To investigate the anti-inflammatory effect ofCoptis chinensisplus myrobalan (CM) in vitro and in vivo.Methods. The inflammation in mouse peritoneal macrophages was induced by lipopolysaccharide (LPS). Animal models were established by using ear swelling and paw edema of mouse induced by xylene and formaldehyde, respectively. In vitro, cytotoxicity, the phagocytosis of macrophages, the levels of nitric oxide (NO), induced nitric oxide synthase (iNOS), tumor necrosis factor-α(TNF-α), and interleukin-6 (IL-6) in cell supernatant were detected. In vivo, swelling rate and edema inhibit

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Borges, Rodrigo, Marcus Vinícius Mariano Nascimento, Adryano Augustto Valladão de Carvalho, et al. "Antinociceptive and Anti-Inflammatory Activities of the Ethanolic Extract fromSynadenium umbellatumPax. (Euphorbiaceae) Leaves and Its Fractions." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/715650.

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Synadenium umbellatumPax., popularly known in Brazil as “cola-nota,” “avelós,” “cancerola,” and “milagrosa”, is a plant species used in folk medicine for the treatment of inflammation, pain, and several diseases. This study aimed to investigate the antinociceptive and anti-inflammatory activities of the ethanolic extract fromSynadenium umbellatumPax. leaves (EES) and its hexane (HF), chloroform (CF), and methanol/water (MF) fractions using the acetic acid-induced abdominal writhing test, formalin-induced paw licking test, tail flick test, croton oil-induced ear edema test, and carrageenan-indu

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SHEPARD, THOMAS H., and ALAN G. FANTEL. "Pathogenesis of congenital defects associated with Turner's syndrome: the role of hypoalbuminemia and edema." Acta Endocrinologica 113, no. 4_Suppl (1986): S440—S447. http://dx.doi.org/10.1530/acta.0.112s440.

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Abstract: Studies of prenatal fetuses with 45,X Turner syndrome have allowed for plausible hypotheses of how their pitting edema may lead to production of the associated congenital defects found in the condition. Hypoalbuminemia in these fetuses which are only about one-sixth the levels found in newborns and one-third the level in "control" fetuses may explain the edema. Malformation of the ear, hairline, neck webbing, nipples, coarctation, nails and horseshoe kidney can be related to embryonic and fetal deformation from edema.

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Ana Silvia, Gutiérrez-Román, Trejo-Tapia Gabriela, Herrera-Ruiz Maribel, et al. "Effect of Terpenoids and Flavonoids Isolated from Baccharis conferta Kunth on TPA-Induced Ear Edema in Mice." Molecules 25, no. 6 (2020): 1379. http://dx.doi.org/10.3390/molecules25061379.

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In this study, we isolated from the aerial parts of Baccharis conferta Kunth (i) a new neoclerodane, denominated “bacchofertone”; (ii) four known terpenes: schensianol A, bacchofertin, kingidiol and oleanolic acid; and (iii) two flavonoids: cirsimaritin and hispidulin. All structures were identified by an exhaustive analysis of nuclear magnetic resonance (NMR) and mass spectroscopy (MS). Extracts from aerial parts were screened for anti-inflammatory activity in the mice ear edema model of 12-O-tetradecanoylforbol-13-acetate mice. Dichloromethane extract (BcD) exhibited 78.5 ± 0.72% inhibition

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Chen, Min, Ying Qin, Hang Ma та ін. "Downregulating NF-κB signaling pathway with triterpenoids for attenuating inflammation: in vitro and in vivo studies". Food & Function 10, № 8 (2019): 5080–90. http://dx.doi.org/10.1039/c9fo00561g.

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Two triterpenoids from Acanthopanax trifoliatus, an edible medicinal plant from Southeast Asia, attenuated lipopolysaccharides-induced inflammation in murine macrophage RAW246.7 cells and tetradecanoylphorbolacetate-induced mouse ear edema.

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Kehili, Sarah, Mohamed Amine Boukhatem, Asma Belkadi, Faiza Boulaghmen, Mohamed Amine Ferhat, and William N. Setzer. "Spearmint (Mentha spicata L.) essential oil from tipaza (Algeria): in vivo anti-inflammatory and analgesic activities in experimental animal models." Acta Pharmaceutica Hungarica 90, no. 1 (2020): 15–26. http://dx.doi.org/10.33892/aph.2020.90.15-26.

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Introduction Although analgesic and nonsteroidal anti-inflammatory drugs (NSAIDs) are usually used to treat a diversity of illnesses, their administration is linked with acute kidney injury and gastrointestinal side effects. The research of new biomolecules and natural products is still needed such as medicinal plants. Aims The present research was aimed to investigate, for the first time, the anti-inflammatory and anti-nociceptive effects of spearmint essential oil (SEO) in mouse models of acute inflammation and pain. Materials and Method Chemical analysis of SEO was done by gas chromatograph

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Moreno-Quiros, Claudia V., Victor Garcia-Escalante, Alberto Sanchez-Medina, et al. "Croton stipulaceusKunth, a native Mexican medicinal plant with antioxidant and anti-inflammatory activities." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 23, no. 4 (2024): 523–33. http://dx.doi.org/10.37360/blacpma.24.23.4.35.

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Leaves of Croton stipulaceuswere extracted (EHex, ECHCl3and EEtOH extracts) to assesstheir antioxidant potential, anti-inflammatory activity in murine models and acute toxicity. EEtOH showed the highest effect in DPPH (37.80% inhibition), FRAP (1065.00 ± 55.30 μmolFe2+) and total polyphenols (231.24 ± 9.05 meq AG/gM). EHex was the most active, ~ 50% inhibition of TPA-induced ear edema; while EEtOH (dose of 2 mg/ear) showed the highest inhibition in the chronic model (97% inhibition), and inhibited MPO activity (48%). In carrageenan-induced edema, ECHCl3(dose 500 mg/kg) was the most active. Non

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Ohashi, Yoshihiro, Hiroshi Ikeoka, Yoshiaki Nakai, Hiroyuki Koshimo, Yusuke Esaki, and Yasuto Onoyama. "Acute Effects of Irradiation on Middle Ear Mucosa." Annals of Otology, Rhinology & Laryngology 97, no. 2 (1988): 173–78. http://dx.doi.org/10.1177/000348948809700215.

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Single field, fixed irradiation of bilateral tympanic cavities using 200-kV x-rays was administered to five guinea pigs. The irradiation dose was 30 Gy. They were killed immediately after irradiation, and bilateral middle ear mucosa was examined for ciliary activity and epithelial structure. Significant deterioration of the ciliary activity in the middle ear mucosa was observed, proximal as well as distal to the eustachian tube. Electron microscopy showed various changes in the irradiated middle ear mucosa. The most conspicuous findings were hyperreactivity in secretion, vacuolation of ciliate

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Liang, Jia-Li, Jia-Zhen Wu, Yu-Hong Liu та ін. "Patchoulene Epoxide Isolated from Patchouli Oil Suppresses Acute Inflammation through Inhibition of NF-κB and Downregulation of COX-2/iNOS". Mediators of Inflammation 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/1089028.

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According to the GC-MS analysis, compositional variation was observed between samples of patchouli oil, of which an unknown compound identified as patchoulene epoxide (PAO) was found only in the long-stored oil, whose biological activity still remains unknown. Therefore, the present study aimed to evaluate the potential anti-inflammatory activity with three in vivo inflammatory models: xylene-induced ear edema, acetic acid-induced vascular permeability, and carrageenan-induced paw edema. Further investigation into its underlying mechanism on carrageenan-induced paw edema was conducted. Results

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Sangchart, Pimpichaya, Panyada Panyatip, Teerasak Damrongrungruang, Aroonsri Priprem, Pramote Mahakunakorn, and Ploenthip Puthongking. "Anti-Inflammatory Comparison of Melatonin and Its Bromobenzoylamide Derivatives in Lipopolysaccharide (LPS)-Induced RAW 264.7 Cells and Croton Oil-Induced Mice Ear Edema." Molecules 26, no. 14 (2021): 4285. http://dx.doi.org/10.3390/molecules26144285.

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The pineal gland is a neuroendocrine organ that plays an important role in anti-inflammation through the hormone melatonin. The anti-inflammatory effects of melatonin and its derivatives have been reported in both in vitro and in vivo models. Our previous study reported the potent antioxidant and neuroprotective activities of bromobenzoylamide substituted melatonin. In silico analysis successfully predicted that melatonin bromobenzoylamid derivatives were protected from metabolism by CYP2A1, which is a key enzyme of the melatonin metabolism process. Therefore, the anti-inflammatory activities

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Fan, Chao, Hui-zi Jin, Lehao Wu, et al. "An Exploration of Traditional Chinese Medicinal Plants with Anti-Inflammatory Activities." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/1231820.

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In a continuing effort to discover more anti-inflammatory medicinal plants in China, the anti-inflammatory activities of 101 extracts from different parts of 84 traditional medicinal plants were evaluated by a panel of in vitro and in vivo assays. Nuclear factor-kappa B (NF-κB) inhibitory effects were determined by luciferase assay in stably transfected Hela cells. Cytotoxic activities were assessed using the MTT assay. Inhibitory effects on LPS-induced nitric oxide production and proinflammatory mediators were assessed by Griess reaction and Real-Time PCR analysis, respectively. In vivo anti-

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Chanshetti, R. R., and D. D. Bandawane. "Investigation of Flavonoids in Stereospermum suaveolens DC Leaves (Patala) Using HPTLC Analysis for Inflammatory Pain, Swelling, and Edema Treatment." Asian Pacific Journal of Health Sciences 9, no. 3 (2022): 80–85. http://dx.doi.org/10.21276/apjhs.2022.9.3.17.

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Background: As per extensive research study, it was observed that Stereospermum suaveolens DC (Patala) is rich sources of flavonoids. These phytoconstituents have played an important role in prevention and maintenance of acute and chronic diseases of pain and inflammation. There is need to explore method for identification and quantification of the presence of flavonoids in S. suaveolens DC leaves (SSL) by qualitatively and quantitatively and to establish its mechanism in pain, swelling and edema Aim: The aim of the study was to identify and assess role of flavonoids in SSL by high-performance

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Zhang, Mai, Jeffery M. Cowden, Paul J. Dunford, and Robin L. Thurmond. "The Histamine H4 Receptor (H4R) Mediates Inflammatory Responses in a Th2-dependent, FITC-induced Atopic Dermatitis Model (B199)." Journal of Immunology 178, no. 1_Supplement (2007): LB42. http://dx.doi.org/10.4049/jimmunol.178.supp.b199.

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Abstract Histamine is an important inflammatory mediator in atopic dermatitis. The histamine H4 receptor (H4R), primarily expressed on immune cells, affects Th2 responses, dendritic cell functions, eosinophil and mast cell chemotaxis. Recent studies also demonstrate its role in experimental pruritus. In this study, we investigated the function of H4R in a Th2-dependent mouse model of atopic dermatitis. Mice were sensitized with Fluorescein isothiocyanate (FITC) on the abdominal skin, and later challenged with FITC on the ear. Ear edema and pruritic response were then evaluated. The experimenta

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López, Alfonso, David E. Sims, Richard F. Ablett, et al. "Effect of emu oil on auricular inflammation induced with croton oil in mice." American Journal of Veterinary Research 60, no. 12 (1999): 1558–61. http://dx.doi.org/10.2460/ajvr.1999.60.12.1558.

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Abstract Objective To determine the acute anti-inflammatory effects of topically applied emu oil. Animals 96 male CD-1 mice assigned randomly to 4 groups, each comprising 24 mice. Procedure To induce auricular inflammation, 50 μl of a solution comprising 10 μl of croton oil dissolved in 1 ml of acetone was applied to the inner surface of the left auricle (pinna). One hour later, 3 or 5 μl of emu oil (low- and high-dose groups, respectively) or 5 μl of porcine oil (oil-control) was applied to the left pinna. Control mice remained untreated. Six mice per group were euthanatized 3, 6, 12, and 24

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Lim, Hyung Jin, Seon Gyeong Bak, Eun Jae Park та ін. "Retrofractamide C Derived from Piper longum Alleviates Xylene-Induced Mouse Ear Edema and Inhibits Phosphorylation of ERK and NF-κB in LPS-Induced J774A.1". Molecules 25, № 18 (2020): 4058. http://dx.doi.org/10.3390/molecules25184058.

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Many studies have reported the biological activities of retrofractamide C (RAC). However, few studies have investigated the anti-inflammatory effect of RAC. In the present study, we investigated the anti-inflammatory effect of RAC using lipopolysaccharide (LPS)-induced J774A.1 cells and a xylene-induced mouse ear edema model. Treatment with RAC decreased LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) secretion and inducible NO synthase (iNOS) and cyclooxygenase 2 (COX2) protein expression. It also downregulated the LPS-induced production of interleukin-1β (IL-1β) and interleukin-6 (

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Saidi, Odoma, Zezi A. Umar, Danjuma N. Muhammed, Ahmed Abubakar, M. Garba Magaji, and Munir A. Sani. "Preliminary Evaluation of the Acute and Sub-Acute Anti-Inflammatory Activities of Aqueous and Butanol Leaf Fractions of Olax subscorpioidea Oliv. (Olacaceae)." Journal of Phytomedicine and Therapeutics 19, no. 2 (2021): 398–409. http://dx.doi.org/10.4314/jopat.v19i2.5.

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Olax subscorpioidea (Oliv.) leaf is widely used as a traditional remedy for pain, reduction of small tumors, edema, painful swellings, and other inflammatory conditions. Its anti-inflammatory potential in experimental animals has been documented. Furthermore, an anti-inflammatory assay guided fractionation showed that the aqueous and butanol leaf fractions were the most active. This study is aimed at investigating further, the acute and sub-acute anti-inflammatory potentials of the aqueous and butanol leaf fractions in mice and rats.Carrageenan induced paw edema in rats, xylene induced ear ede

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Gonçalves, Gabriela Mastrangelo, Joyce Mattos de Oliveira, Thayane Ferreira da Costa Fernandes, et al. "Evaluation of the in vivo and in vitro anti-inflammatory activity of a new hybrid NSAID tetrahydropyran derivative." Canadian Journal of Physiology and Pharmacology 100, no. 4 (2022): 341–51. http://dx.doi.org/10.1139/cjpp-2021-0437.

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Evaluate the anti-inflammatory activity in vivo and in vitro of cis-(±)-acetate of 4-chloro-6-(naphtalene-1-yl)-tetrahydro-2H-pyran-2-yl) methyl 2-(2-(2,6-diclorofenylamine) phenyl (LS19). Male Swiss mice were analyzed in the paw edema, ear edema, and air pouch tests, and in vitro COX inhibition, cytotoxicity evaluation, and cytokine and nitric oxide determination tests. The compound showed effect on the carrageenan- and bradykinin-induced paw edema and capsaicin-induced ear edema tests. In addition, the compound was able to inhibit leukocyte migration to decrease the levels of the pro-inflamm

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Wu, Xiao-Li, Chu-Wen Li, Hai-Ming Chen, et al. "Anti-Inflammatory Effect of Supercritical-Carbon Dioxide Fluid Extract from Flowers and Buds ofChrysanthemum indicumLinnén." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/413237.

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The aim of this study was to analyze the chemical composition and investigate the anti-inflammatory property of the supercritical-carbon dioxide extract from flowers and buds ofC. indicum(CISCFE). The anti-inflammatory effect was evaluated in four animal models including xylene-induced mouse ear edema, acetic acid-induced mouse vascular permeability, carrageenan-induced mouse hind paw edema, and cotton pellet-induced rat granuloma formation. The results indicated that CISCFEsignificantly attenuated xylene-induced ear edema, decreased acetic acid-induced capillary permeability, reduced carragee

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