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Journal articles on the topic 'Early onset cataract'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Irfanur, Rahman, Kumari Pallavi, Karak Pradeep, and Prasad Vivek. "Clinical Evaluation of Cataract and its Management in Paediatric Patients." International Journal of Pharmaceutical and Clinical Research 16, no. 4 (2024): 453–58. https://doi.org/10.5281/zenodo.11177638.

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<strong>Background and Objectives:</strong> Paediatric cataracts account visual loss in childhood. Early diagnosis and timely intervention is of at most importance as cataracts interfere with normal visual development. To evaluate the visual results after cataract surgery in children aged below 15 years and to evaluate the different causes of visual impairment following cataract surgery. <strong>Methods:</strong> A prospective study of 30 cases of paediatric cataract was conducted in Nalanda Medical College and Hospital Patna. A detailed ophthalmic and systemic examination was d

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2

A, Gupta, and Verma AK. "Association of Serum 25-Hydroxyl Vitamin D Deficiency and Idiopathic Presenile Cataract -A Hospital Based Study." Open Access Journal of Ophthalmology 10, no. 2 (2025): 1–5. https://doi.org/10.23880/oajo-16000340.

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Background: Cataract is the leading cause of blindness in India mainly due to age related changes in the lens. Early onset cataract can be visually debilitating having high societal burden requiring early surgical intervention. Identifying modifiablerisk factors can delay or prevent early onset cataractous changes.Aim of the study: The aim of this study was to determine any association between Serum 25-Hydroxyl (25-OH ) Vitamin D Deficiency and Idiopathic Presenile CataractMaterials and Methods: The study was undertaken at Tertiary care hospital in hilly state of India. A detailed medical hist

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Gunaratne, Naiomi C., Tara Rajiyah, Dianne Deplewski, et al. "LBODP084 Bilateral Cataracts In A 15-year-old Girl With New-onset Type 1 Diabetes Mellitus." Journal of the Endocrine Society 6, Supplement_1 (2022): A595. http://dx.doi.org/10.1210/jendso/bvac150.1232.

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Abstract Background Cataracts secondary to Type 1 or Type 2 Diabetes is not uncommon in adults, however, it is a rare finding in pediatrics patients with Type 1 Diabetes. Clinical Case A 15-year-old girl presented with progressively worsened bilateral vision for 6 months, however, vision rapidly deteriorated over the previous month, prompting visit to optometrist. No history of weight loss, however, did report 1.5 years of polydipsia, polyuria, and polyphagia. Outside optometrist reported concerns for cataracts. She presented to our Ophthalmology department one week later, who found bilateral

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Murthy, Sowmya Raveendra, Kirtika Jain, and Simran Hundlani. "Bilateral developmental cataracts in a child with familial lipodystrophy." Indian Journal of Ophthalmology - Case Reports 4, no. 3 (2024): 652–54. http://dx.doi.org/10.4103/ijo.ijo_2120_23.

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Bilateral developmental cataracts are usually caused due to hereditary metabolic disorder or intrauterine infections. Familial lipodystrophy type 7 has variable phenotypes with early-onset cataracts and lower limb spasticity, with most reports showing the onset of cataracts in the second decade of life. We report a rare case of bilateral congenital cataract in a child aged 3 years and 9 months with genetically proven familial partial lipodystrophy type 7. Bilateral developmental cataracts need complete physical examination and genetic analysis to detect unusual and rare causes like familial pa

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Singh, Kaushal Deep, Shahbaz Habib Faridi, and Mehershree Lodhi. "Possible mechanisms of development of carcinoma of breast in patients with early-onset cataract." International Surgery Journal 4, no. 4 (2017): 1394. http://dx.doi.org/10.18203/2349-2902.isj20171149.

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Background: A nation-wide population based retrospective cohort study from Taiwan in 2014 suggested a propensity of developing breast cancer in young females with early-onset cataract. One such patient presented to us who was a young non-obese female with a large lump in the right breast with skin nodules and bilateral painless progressive diminution of vision. Patient was diagnosed as locally advanced carcinoma of right breast with axillary metastasis (stage IIIB) and bilateral early-onset nuclear cataract. Mechanism of this possible association has never been described.Methods: A comprehensi

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Wong, Karen, Yousef Barbin, Subrata Chakrabarti, and Paul Adams. "A Point Mutation in the Iron-Responsive Element of the L-Ferritin in a Family with Hereditary Hyperferritinemia Cataract Syndrome." Canadian Journal of Gastroenterology 19, no. 4 (2005): 253–55. http://dx.doi.org/10.1155/2005/796963.

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BACKGROUND: Hereditary hyperferritinemia cataract syndrome is an autosomal dominant condition that is characterized by a high serum ferritin level and bilateral early-onset cataracts in the absence of iron overload. The genetic abnormality is identified as a mutation in the 5' regulatory region of the L-ferritin messenger RNA known as the iron-responsive element (IRE). The IRE controls ferritin synthesis in response to cytoplasmic iron pools by interacting with regulatory proteins called iron responsive proteins. Mutations in the IRE decrease its affinity for iron responsive proteins, leading

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Ferreira, Rosane C., Elizabeth R. Roeder, and J. Bronwyn Bateman. "Cataract in early onset and classic Cockayne syndrome." Ophthalmic Genetics 18, no. 4 (1997): 193–97. http://dx.doi.org/10.3109/13816819709041434.

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Tsai, Lung-Hui, Ching-Chung Chen, Chien-Ju Lin, Sheng-Pei Lin, Ching-Ying Cheng, and Hsi-Pao Hsieh. "Risk Factor Analysis of Early-Onset Cataracts in Taiwan." Journal of Clinical Medicine 11, no. 9 (2022): 2374. http://dx.doi.org/10.3390/jcm11092374.

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Purpose: According to previous studies, the prevalence rate of cataracts has increased in recent years. This study aims to investigate and analyze the risk factors of early-onset cataracts in Taiwan. Methods: A total of 71 subjects aged between 20 and 55 were diagnosed with cataracts in a medical center. Participants were divided into three groups: control, early-onset cataract (EOC), and combined (EOC combined with dry eye) groups. Eye examinations including autorefraction, best-corrected visual acuity (BCVA), subjective refraction, axial length, fundus, slit lamp, and reactive oxygen species

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Mutlu, Fatih Mehmet, Haluk Duman, and Yakup Çİl. "Early-Onset Unilateral Electric Cataract: A Rare Clinical Entity." Journal of Burn Care & Rehabilitation 25, no. 4 (2004): 363–65. http://dx.doi.org/10.1097/01.bcr.0000132167.03930.db.

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10

Grigoryeva, Y. V., and S. Y. Kopaev. "Surgical treatment of complicated cataract in patients with high-grade ametropia." POINT OF VIEW. EAST – WEST, no. 3 (October 27, 2023): 33–37. http://dx.doi.org/10.25276/2410-1257-2023-3-33-37.

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Purpose. To present a review of current literature data on cataract surgery in patients with high-grade ametropia. Material and methods. In order to achieve this purpose, we searched PubMed abstract databases for publications using the key words «cataract», «high hyperopia», «high myopia» for the period from 2000 to 2023 inclusive. Conclusion. The review reflects increased attention to problems of phacoemulsification in patients with complicated cataracts and high-grade ametropias, which is associated with their high prevalence, early onset cataracts, tendencies to progress and develop complic

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Jarwar, Priya, Shakeel Ahmed Sheikh, Yar Muhammad Waryah, et al. "Biallelic Variants in EPHA2 Identified in Three Large Inbred Families with Early-Onset Cataract." International Journal of Molecular Sciences 22, no. 19 (2021): 10655. http://dx.doi.org/10.3390/ijms221910655.

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Hereditary congenital cataract (HCC) is clinically and genetically heterogeneous. We investigated HCC that segregates in three inbred families (LUCC03, LUCC16, and LUCC24). Ophthalmological examinations revealed cataracts with variability related to the age of onset segregating in a recessive manner in these families. Exome sequencing of probands identified a novel homozygous c.2710delG;p.(Val904Cysfs*36) EPHA2 variant in LUCC03 and a known homozygous c.2353G>A;p.(Ala785Thr) EPHA2 variant in the other two recessive families. EPHA2 encodes a transmembrane tyrosine kinase receptor, which is p

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Kang, Kui Dong, Hye Bin Yim, and Albert W. Biglan. "Comparison of Delayed-Onset Glaucoma and Early-Onset Glaucoma after Infantile Cataract Surgery." Korean Journal of Ophthalmology 20, no. 1 (2006): 41. http://dx.doi.org/10.3341/kjo.2006.20.1.41.

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13

Achyut, N. Pandey. "Traumatic Cataract." Ophthalmology Research: An International Journal 7, no. 1 (2017): 1–8. https://doi.org/10.9734/OR/2017/32631.

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Traumatic cataract is more common in younger individuals. Traumatic cataract is an important cause of uniocular visual loss and is often sudden in onset. Traumatic lens damage may be caused by mechanical or non-mechanical injury. Traumatic cataract is an indication of intraocular lens (IOL) implantation in children. In trauma visual outcome depends on the interval from injury to the surgery. Early intervention provides better visual outcome and less chance of developing amblyopia and strabismus. Intraocular lens implantation for unilateral cataract in children has a definite role in correcting

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Papadopoulos, Constantinos, Grigoris Panagopoulos, Kyriaki Kekou, Vassilios Fardis, Sofia Kitsiou-Tzeli, and GeorgeK Papadimas. "Author's Reply: Myotonic dystrophy: The occurrence of early-onset cataract." Neurology India 65, no. 4 (2017): 923. http://dx.doi.org/10.4103/neuroindia.ni_481_17.

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Papadopoulos, C., S. Xirou, K. Kekou, S. Kitsiou-Tzeli, E. Kararizou, and G. Papadimas. "Early onset cataract: prominent feature in myotonic dystrophy type 2." Neuromuscular Disorders 27 (October 2017): S179—S180. http://dx.doi.org/10.1016/j.nmd.2017.06.313.

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Callanan, David, Ingrid U. Scott, Timothy G. Murray, Karen W. Oxford, C. Bradley Bowman, and Harry W. Flynn. "Early Onset Endophthalmitis Caused by Aspergillus Species Following Cataract Surgery." American Journal of Ophthalmology 142, no. 3 (2006): 509–11. http://dx.doi.org/10.1016/j.ajo.2006.03.053.

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Bajraktari, Gentian, Tomislav Jukić, Miro Kalauz, Martin Oroz, Andrea Radolović Bertetić, and Nenad Vukojević. "Early and Late Complications after Cataract Surgery in Patients with Uveitis." Medicina 59, no. 10 (2023): 1877. http://dx.doi.org/10.3390/medicina59101877.

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Background and Objectives: Uveitis, a prevalent eye disorder characterized by inflammatory processes, often leads to cataract formation and significant visual impairment. This study aimed to evaluate preoperative conditions and postoperative outcomes following cataract surgery in uveitis patients. Materials and Methods: A retrospective study was conducted at the University Hospital Center Rebro Zagreb, Croatia, involving uveitis patients who underwent cataract surgery between 2013 and 2022. Eligible patients had uveitic cataracts affecting visual acuity or posterior segment visualization in a

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Ali, Syed M., Abdulrahman Gharkan, Thomas M. Bosley, and Igor Kozak. "Novel Ocular Features in a Child with Marinesco-Sjögren Syndrome: Case Report and Literature Review." SN Comprehensive Clinical Medicine 3, no. 9 (2021): 1968–72. http://dx.doi.org/10.1007/s42399-021-00974-5.

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AbstractTo report novel ocular findings in unique Marinesco-Sjögren syndrome (early-onset cataracts, cerebellar ataxia, and a progressive myopathy), review literature, and discuss causes of vision decrease in this rare entity. A 3-year-old girl diagnosed with Marinesco-Sjögren syndrome underwent uneventful cataract surgery in both eyes within 1 week of her 2nd birthday. This was exactly similar to her sister and other two related family members. Additionally, she had prominent corneal nerves and subtle corneal subepithelial deposits in both eyes. Cataracts are one of the primary diagnostic cri

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Gawdat, Ghada I., Maha M. Youssef, Nermeen M. Bahgat, Dina M. Elfayoumi, and Mohamed AS Eddin. "Incidence and Risk Factors of Early-onset Glaucoma following Pediatric Cataract Surgery in Egyptian Children: A One-year Study." Journal of Current Glaucoma Practice 11, no. 3 (2017): 80–85. http://dx.doi.org/10.5005/jp-journals-10028-1229.

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ABSTRACT Aim To study the incidence and risk factors of glaucoma occurring within 1 year following pediatric cataract surgery in Egyptian children. Materials and methods This is a prospective nonrandomized study conducted at Aburich Children's Hospital, over a period of 1 year on a cohort of Egyptian patients with congenital and infantile cataract. One hundred and fifty eyes of 88 patients were enrolled in this study. All the patients underwent anterior approach removal of lens matter, whereas primary intraocular lens (IOL) implantation was carried at the age of 1 and 2 years for unilateral an

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20

Volkmann, Martin, Rudolf Richter, Thomas Herrmann, et al. "Hereditary hyperferritinaemia-cataract syndrome (HHCS) – an underestimated condition: ferritin light chain variant spectrum in German families." Clinical Chemistry and Laboratory Medicine (CCLM) 57, no. 12 (2019): 1837–45. http://dx.doi.org/10.1515/cclm-2018-1354.

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Abstract Background In hereditary hyperferritinaemia-cataract syndrome (HHCS), single nucleic acid alterations in the ferritin light chain (L-ferritin) iron response element (IRE) constitutively derepress ferritin synthesis, resulting in hyperferritinaemia, L-ferritin deposits in the lens of the eye and early bilateral cataract onset. Methods In this study, six German families with putative HHCS were analysed. Clinical diagnosis of HHCS was based on medical history, evaluation of ferritin serum levels, transferrin saturation and clinical ophthalmological examination. Diagnosis was confirmed by

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21

Nguyen, Xuan-Thanh-An, Hind Almushattat, Ine Strubbe, et al. "The Phenotypic Spectrum of Patients with PHARC Syndrome Due to Variants in ABHD12: An Ophthalmic Perspective." Genes 12, no. 9 (2021): 1404. http://dx.doi.org/10.3390/genes12091404.

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This study investigated the phenotypic spectrum of PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa and early-onset cataract) syndrome caused by biallelic variants in the ABHD12 gene. A total of 15 patients from 12 different families were included, with a mean age of 36.7 years (standard deviation [SD] ± 11.0; range from 17.5 to 53.9) at the most recent examination. The presence and onset of neurological, audiological and ophthalmic symptoms were variable, with no evident order of symptom appearance. The mean best-corrected visual acuity was 1.1 logMAR (SD ± 0.9; range from 0.

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Hetet, Gilles, Isabelle Devaux, Nadem Soufir, Bernard Grandchamp, and Carole Beaumont. "Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (slc11A3) mutations." Blood 102, no. 5 (2003): 1904–10. http://dx.doi.org/10.1182/blood-2003-02-0439.

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AbstractUnexplained hyperferritinemia is a common clinical finding, even in asymptomatic persons. When early onset bilateral cataracts are also present, the hereditary hyperferritinemia-cataract syndrome (HHCS), because of heterozygous point mutation in the L ferritin iron-responsive element (IRE) sequence, can be suspected. We sequenced the L ferritin exon 1 in 52 DNA samples from patients referred to us for molecular diagnosis of HHCS. We identified 24 samples with a point mutation/deletion in the IRE. For the 28 samples in which no IRE mutation was present, we also genotyped HFE mutations a

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Imelda, Eva, and Vania Ghassani. "Innovative Strategies in Managing Early-Onset Primary Congenital Glaucoma." Indonesian Journal of Case Reports 2, no. 2 (2024): 33–36. https://doi.org/10.60084/ijcr.v2i2.190.

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Congenital glaucoma has the potential to damage the visual nerve fibers, leading to permanent blindness. This case report aims to provide timely and appropriate management upon diagnosis. The case involves a 5-month-old baby girl delivered via spontaneous normal delivery at 36-37 weeks, with a birth weight of 3100 grams, who presented with complaints of left eye enlargement since one month of age, persistent watery eyes, and photophobia when exposed to sunlight. Diagnoses included Primary Congenital Glaucoma, Congenital Cataract, and Exotropia Oculi Sinistra. The patient received preoperative

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Khan, Arif O., Carsten Bergmann, Christine Neuhaus, and Hanno J. Bolz. "A Distinct Vitreo-retinal Dystrophy with Early-onset Cataract from RecessiveKCNJ13Mutations." Ophthalmic Genetics 36, no. 1 (2014): 79–84. http://dx.doi.org/10.3109/13816810.2014.985846.

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Çakır, Mehmet, Serhat İmamoğlu, Osman Çekiç, et al. "An Outbreak of Early-Onset Endophthalmitis Caused byFusariumSpecies following Cataract Surgery." Current Eye Research 34, no. 11 (2009): 988–95. http://dx.doi.org/10.3109/02713680903254822.

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Armitage, Marlene M., Jane D. Kivlin, and Robert E. Ferrell. "A progressive early onset cataract gene maps to human chromosome 17q24." Nature Genetics 9, no. 1 (1995): 37–40. http://dx.doi.org/10.1038/ng0195-37.

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Shiels, Alan. "Through the Cat-Map Gateway: A Brief History of Cataract Genetics." Genes 15, no. 6 (2024): 785. http://dx.doi.org/10.3390/genes15060785.

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Clouding of the transparent eye lens, or cataract(s), is a leading cause of visual impairment that requires surgical replacement with a synthetic intraocular lens to effectively restore clear vision. Most frequently, cataract is acquired with aging as a multifactorial or complex trait. Cataract may also be inherited as a classic Mendelian trait—often with an early or pediatric onset—with or without other ocular and/or systemic features. Since the early 1990s, over 85 genes and loci have been genetically associated with inherited and/or age-related forms of cataract. While many of these underly

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Shenoy, Rathika D., Deepthi R. V., Nutan Kamath, and Sumana J. Kamath. "DEVELOPMENTAL DELAY IN CHILDHOOD CATARACT: A CAVEAT MARINESCO-SJÖGREN SYNDROME." Journal of Health and Allied Sciences NU 04, no. 03 (2014): 121–23. http://dx.doi.org/10.1055/s-0040-1703818.

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AbstractWe report on a child with Marinesco-Sjögren Syndrome, a rare autosomal recessive disorder characterised by early onset cataract, psychomotor delay, cerebellar hypoplasia and myopathy. The presentation, neuro-imaging and muscle biopsy features are discussed.

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Siddam, Archana D., Matthieu Duot, Sarah Y. Coomson, et al. "High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology." Cells 12, no. 7 (2023): 1070. http://dx.doi.org/10.3390/cells12071070.

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Defects in the development of the ocular lens can cause congenital cataracts. To understand the various etiologies of congenital cataracts, it is important to characterize the genes linked to this developmental defect and to define their downstream pathways that are relevant to lens biology and pathology. Deficiency or alteration of several RNA-binding proteins, including the conserved RBP Celf1 (CUGBP Elav-like family member 1), has been described to cause lens defects and early onset cataracts in animal models and/or humans. Celf1 is involved in various aspects of post-transcriptional gene e

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Barnum, Carrie E., Salma Al Saai, Shaili D. Patel, et al. "The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology." Human Molecular Genetics 29, no. 12 (2020): 2076–97. http://dx.doi.org/10.1093/hmg/ddaa096.

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Abstract Mutations of the RNA granule component TDRD7 (OMIM: 611258) cause pediatric cataract. We applied an integrated approach to uncover the molecular pathology of cataract in Tdrd7−/− mice. Early postnatal Tdrd7−/− animals precipitously develop cataract suggesting a global-level breakdown/misregulation of key cellular processes. High-throughput RNA sequencing integrated with iSyTE-bioinformatics analysis identified the molecular chaperone and cytoskeletal modulator, HSPB1, among high-priority downregulated candidates in Tdrd7−/− lens. A protein fluorescence two-dimensional difference in-ge

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Horga, Alejandro, Enrico Bugiardini, Andreea Manole, et al. "Autosomal dominant optic atrophy and cataract “plus” phenotype including axonal neuropathy." Neurology Genetics 5, no. 2 (2019): e322. http://dx.doi.org/10.1212/nxg.0000000000000322.

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ObjectiveTo characterize the phenotype in individuals with OPA3-related autosomal dominant optic atrophy and cataract (ADOAC) and peripheral neuropathy (PN).MethodsTwo probands with multiple affected relatives and one sporadic case were referred for evaluation of a PN. Their phenotype was determined by clinical ± neurophysiological assessment. Neuropathologic examination of sural nerve and skeletal muscle, and ultrastructural analysis of mitochondria in fibroblasts were performed in one case. Exome sequencing was performed in the probands.ResultsThe main clinical features in one family (n = 7

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Anindi Putri Harjanti and Diana Putri. "The Analysis Study of Association of Myopia and Age-Related Cataract : A Comprehensive Systematic Review." International Journal of Medical Science and Health Research 7, no. 3 (2024): 23–41. https://doi.org/10.70070/pcdfr347.

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Background: Myopia is a refractive error characterized by the inability to focus on distant objects due to an elongated axial length of the eye. Several studies have suggested that myopia, especially high myopia, may be a risk factor for early-onset cataracts. This systematic review aims to evaluate the association between myopia and age-related cataracts based on literatures of the last decade. Methods: The study followed PRISMA 2020 guidelines, reviewing English-language publications from 2014 to 2024. Editorials, duplicate reviews from the same journal, and papers lacking a DOI were exclude

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Rostami, Benjamin, Jack Tian, Nicholas Jackson, Rustum Karanjia, and Kenneth Lu. "High Rate of Early Posterior Capsule Opacification following Femtosecond Laser-Assisted Cataract Surgery." Case Reports in Ophthalmology 7, no. 3 (2016): 491–95. http://dx.doi.org/10.1159/000449124.

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Purpose: To compare the rates of rapid posterior capsule opacification (PCO) formation in the first 3 months following femtosecond laser-assisted cataract surgery (FLACS) to manual anterior capsulorhexis. Methods: Retrospective review of 29 cases of FLACS, comparing the rates of PCO in the first 3 months following surgery to 50 consecutive cases of manual anterior capsulorhexis. Results: Seven of the 29 FLACS cases developed PCO requiring capsulotomy at 3 months, while none of the control cases required a capsulotomy over the same time period (p < 0.05). Conclusion: There is an increased in

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Nygren, Karin, Sari Jalomäki, Lena Karlstam, and Kristina Narfström. "Hereditary cataracts in Russian Blue cats." Journal of Feline Medicine and Surgery 20, no. 12 (2018): 1105–9. http://dx.doi.org/10.1177/1098612x17752197.

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Objectives The purpose of this study was to investigate the prevalence of cataracts in the Russian Blue breed of cats in Sweden, and to describe the clinical appearance of this presumed inherited form of cataract. Methods A total of 66 Russian Blue cats were examined in Sweden, between March and October 2014, using standard examination techniques. The examined cats were between 3 months and 14 years of age. Pedigrees were collected from all examined cats for genetic studies. Results Mild-to-severe forms of mainly bilateral cataracts were observed in 22/66 examined Russian Blue cats of both sex

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Lodhi, Sikander A. K., G. Ashok Kumar Reddy, and C. Aruna Sunder. "PostoperativeNocardiaEndophthalmitis and the Challenge of Managing with Intravitreal Amikacin." Case Reports in Ophthalmological Medicine 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/2365945.

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Nocardiais a rare cause of delayed onset postoperative endophthalmitis after cataract surgery and it usually carries a guarded visual prognosis.Purpose. To highlight the clinical presentation, microbiological profile, and treatment outcome in a case of nocardial endophthalmitis after manual small incision cataract surgery.Methods. This case report highlights the typical features ofNocardiaendophthalmitis, which presented six weeks after undergoing small incision cataract surgery. The case was managed by pars plana vitrectomy with intravitreal antibiotics. Intravitreal amikacin was used based o

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Sobol, R. "Regulated over-expression of DNA polymerase β mediates early onset cataract in mice". DNA Repair 2, № 5 (2003): 609–22. http://dx.doi.org/10.1016/s1568-7864(03)00026-0.

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Utke Rank, Cecilie, Jesper Petersen, Henrik Birgens, and Ove Juul Nielsen. "Hereditary Hyperferritinemia-cataract Syndrome." European Oncology & Haematology 11, no. 2 (2015): 147. http://dx.doi.org/10.17925/eoh.2015.11.02.147.

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Hereditary hyperferritinemia-cataract syndrome (HHCS) is a rare autosomal dominant disorder associated with high plasma ferritin concentration without iron overload and early-onset bilateral cataract. The deregulation of ferritin production in HHCS is caused by mutations in the iron-responsive elements (IREs) of the ferritin L-subunit gene (FTLgene) – interfering with the high-affinity interaction between IREs and iron regulatory proteins (IRPs), disturbing the negative regulatory control of ferritin synthesis and resulting in excessive production of L-ferritin. We report a 44-year-old woman i

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Crisostomo, Ricardo H., and Christian P. Docena. "Too Much Ferritin, Too Little Overload." Blood 116, no. 21 (2010): 5154. http://dx.doi.org/10.1182/blood.v116.21.5154.5154.

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Abstract Abstract 5154 A healthy 42y/o, White, male, without any systemic illnesses or complaints presents with a serum ferritin of 1800ng/mL; the discrepancy between his optimal physical status and the laboratory result, poses a challenge to the most astute clinician. The fundamental goal of this abstract is to provide recognition and prevention to torment that patients with Hereditary Hyperferritinemia Cataract Syndrome (HHCS) are exposed to. The history will offer an important clue, of early onset cataracts. Our patient was guided by an older sibling who herself for many years underwent unn

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Papadopoulos, C., K. Kekou, S. Xirou, S. Kitsiou-Tzeli, E. Kararizou, and G. K. Papadimas. "Early onset posterior subscapular cataract in a series of myotonic dystrophy type 2 patients." Eye 32, no. 3 (2017): 622–25. http://dx.doi.org/10.1038/eye.2017.280.

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Smith, Patricia Joan, Dennis Eugene Brooks, Jarrod Andrew Lazarus, Paul Scott Kubilis, and Kirk Norman Gelatt. "Ocular hypertension following cataract surgery in dogs: 139 cases (1992-1993)." Journal of the American Veterinary Medical Association 209, no. 1 (1996): 105–11. http://dx.doi.org/10.2460/javma.1996.209.01.105.

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Objective To document the incidence of postoperative ocular hypertension (POH) after cataract surgery in dogs. Design Retrospective analysis of medical records. Sample Population 88 dogs that had had cataract surgery. Procedure The effect of several categorical variables on the development of POH was evaluated statistically. Postoperative ocular hypertension was defined as intraocular pressure > 25 and > 30 mm of Hg. Results The incidence of POH > 25 mm of Hg was 48.9%; > 30 mm of Hg, 33.8%; > 40 mm of Hg, 20.1%; and > 50 mm of Hg, 5.8%. Mean onset of POH > 25 mm of Hg was

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Zafeiropoulos, Paraskevas, Andreas Katsanos, Konstantina Gorgoli, Ioannis Asproudis, and Miltiadis Aspiotis. "LATE-ONSET CAPSULAR BAG DISTENSION SYNDROME: A REPORT OF TWO CASES." Acta Medica (Hradec Kralove, Czech Republic) 57, no. 4 (2014): 165–67. http://dx.doi.org/10.14712/18059694.2015.83.

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Capsular bag distension syndrome is a very rare complication of cataract surgery. Most cases occur after uneventful phacoemulsification with continuous curvilinear capsulorhexis and implantation of an intraocular lens in the capsular bag. The entity presents with reduction of visual acuity and myopic shift in the early-to-late postoperative period. Characteristic findings include the distension of the capsular bag due to the accumulation of milky material and the forward displacement of the intraocular lens. We present two cases with an unusually delayed presentation of 6 and 8 years respectiv

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Mackenbrock, Lars H. B., Jan N. Weindler, Grzegorz Labuz, Isabella D. Baur, Gerd U. Auffarth, and Ramin Khoramnia. "Change in Subfoveal Choroidal Thickness following Cataract Surgery Imaged with Enhanced Depth Imaging Optical Coherence Tomography." Klinische Monatsblätter für Augenheilkunde 240, no. 08 (2023): 989–96. http://dx.doi.org/10.1055/a-2120-7415.

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Abstract Background Due to its invasive nature, cataract surgery can lead to inflammatory processes in the posterior segment, which can result in prolonged recovery times, reduced functional outcomes, and late-onset complications. The aim of the current study was to identify wherever phacoemulsification parameters play a role in choroidal thickness change following cataract surgery. Methods This prospective single-center study enrolled 31 patients (31 eyes) scheduled to undergo routine cataract surgery. Patients with previous ocular surgeries, pathologies or general disorders affecting vision

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Liu, Xiaojing, Jie Yang, Yuhan Zhen, et al. "Rapid contraction of the anterior capsule after phacoemulsification in uveitis: A case report." Medicine 104, no. 28 (2025): e43129. https://doi.org/10.1097/md.0000000000043129.

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Rationale: While capsular contraction syndrome (CCS) typically develops months after cataract surgery, its potential for rapid progression in uveitis patients remains poorly characterized. This case addresses the critical knowledge gap regarding ultra–early-onset CCS and its diagnostic challenges in inflammatory eye disease. Patient concerns: A 63-year-old male with controlled uveitis reported rapidly worsening blurred vision (15 days postphacoemulsification) despite initially good postoperative visual acuity (0.4 at 1 week). The vision deteriorated to hand motion at 10 cm, unresponsive to ant

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Chen, Hsiao-Ling, Hsiu-Mei Chang, Horng-Jiun Wu, et al. "Effect of hydrophilic and lipophilic statins on early onset cataract: A nationwide case-control study." Regulatory Toxicology and Pharmacology 124 (August 2021): 104970. http://dx.doi.org/10.1016/j.yrtph.2021.104970.

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Wong, I. B. Y., V. D. Sukthankar, M. Cortina-Borja, and K. K. Nischal. "Incidence of early-onset glaucoma after infant cataract extraction with and without intraocular lens implantation." British Journal of Ophthalmology 93, no. 9 (2009): 1200–1203. http://dx.doi.org/10.1136/bjo.2008.155200.

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Praveen, M. R., G. D. Shah, A. R. Vasavada, P. G. Mehta, C. Gilbert, and G. Bhagat. "A study to explore the risk factors for the early onset of cataract in India." Eye 24, no. 4 (2009): 686–94. http://dx.doi.org/10.1038/eye.2009.137.

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Huang, Chih-Yang, Tung-Sheng Chen, Cheng-Li Lin, and Wei-Syun Hu. "Does early onset cataract increase the risk of ischemic stroke? A nationwide retrospective cohort study." Internal and Emergency Medicine 12, no. 4 (2016): 461–65. http://dx.doi.org/10.1007/s11739-016-1591-7.

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Hatzinicolaou, Stamatia-Lydia, Danai Palaiologou, Antonios G. Antoniadis, et al. "A Study of the Hereditary Hyperferritinemia Cataract Syndrome in Patients of Greek Origin." Blood 120, no. 21 (2012): 3205. http://dx.doi.org/10.1182/blood.v120.21.3205.3205.

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Abstract Abstract 3205 Background: Hereditary hyperferritinemia cataract syndrome (HHCS) is an autosomal dominant disorder characterized by elevated serum L-ferritin and early onset bilateral cataracts. The syndrome, first described in Italy and France in 1995, is caused by mutations in the iron responsive element (IRE) of the L-ferritin gene (FTL-ferritin light chain) on chromosome 19q13.3. The conformational changes in the mutated IRE disrupt the binding of the iron regulatory proteins (IRPs) to the IRE, resulting in loss of the posttranscriptional control in L-ferritin synthesis. L-ferritin

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Yamini K and Rashmi G. "Risk factors for presenile cataract." Indian Journal of Clinical and Experimental Ophthalmology 10, no. 4 (2024): 684–87. https://doi.org/10.18231/j.ijceo.2024.120.

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To assess the risk factors causing presenile cataract.: This was a cross sectional study comprised of 80 patients in a tertiary care centre in kolar district, who underwent comprehensive eye examination with detailed history including systemic diseases and usage of medication. Complete ophthalmological examination included best corrected visual acuity using Snellens visual acuity chart, anterior segment evaluation with slit-lamp biomicroscopy and intraocular pressure measurement using non-contact tonometer. After pupillary dilatation with topical phenylephrine-tropicamide eye drops, cataract w

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Tudu, KC, and B. Padhan. "Visual Outcome in Patients of Lens Induced Glaucoma by Surgical Management." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 82–88. https://doi.org/10.5281/zenodo.11397047.

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<strong>Background: </strong>Lens induced glaucoma (LIG) is a type of secondary glaucoma and sight threatening disease. It is common in India and seen in the patient with senile cataract, requiring immediate attention and management to restore vision and prevent blindness. <strong>Aim: </strong>To study the visual outcome and intraocular pressure control following surgical management of lens induced glaucoma. <strong>Materials and Methods: </strong>A total of 64 cases of lens induced glaucoma were included after taking prior consent. The evaluation included best correc

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