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1
Groll, Bettina. "Charakterisierung der Ebf-Faktoren Ebf3 und Ebf4 in vivo und in vitro." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-151125.
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Groll, Bettina [Verfasser], and Josef [Akademischer Betreuer] Mautner. "Charakterisierung der Ebf-Faktoren Ebf3 und Ebf4 in vivo und in vitro / Bettina Groll. Betreuer: Josef Mautner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1028738293/34.
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Kuriki, Mao. "Transient and lineage-restricted requirement of Ebf3 for sternum ossification." Doctoral thesis, Kyoto University, 2020. http://hdl.handle.net/2433/253491.
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京都大学0048
新制・課程博士
博士(医学)
甲第22646号
医博第4629号
新制||医||1044(附属図書館)
京都大学大学院医学研究科医学専攻
(主査)教授 篠原 隆司, 教授 松田 秀一, 教授 安達 泰治
学位規則第4条第1項該当
Doctor of Medical Science
Kyoto University
DFAM
4
Seike, Masanari. "Stem cell niche-specific Ebf3 maintains the bone marrow cavity." Kyoto University, 2018. http://hdl.handle.net/2433/235055.
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Waters, Brent R. "Mechanical Properties of Inconel 718 Processed Using Electron Beam Free Form Fabrication (EBF3)." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/6717.
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Electron beam freeform fabrication (EBF3) is a rapid metal deposition process that works efficiently with the wieldable alloy Inconel 718 (IN 718). EBF3 is a developing additive manufacturing (AM) process that can manufacture IN 718 parts directly from computer aided design (CAD) data. EBF3 can produce parts significantly faster and more energy efficient than competing IN 718 AM technologies. The EBF3 process utilizes metal wire feedstock which is induced into a molten pool using a focused electron beam in a vacuum environment. This allows parts to be built layer by layer, creating intricate shapes that can be produced cheaper and faster than traditionally manufactured IN 718 parts. Furthermore, it allows traditionally manufactured parts to be modified as additional form is added to them using EBF3. Multiple industries rely on IN 718 parts and can utilize this technology including aerospace engineering, oil refinery, nuclear power generation, and food processing.A main drawback of EBF3 is the lack of knowledge of the effect different EBF3 build techniques will have on the properties of the deposited materials. Most of the reliable data on the mechanical properties relate to a linear build-up strategy and focus on the mechanical properties in the deposition direction (DD). There is no data related to other build-up techniques such as rotation build-up or transitional builds from forged material to EBF3 material. Reliable data on the behavior and microstructure of EBF3 material in a direction other than the DD is also difficult to find. Previous studies showed build-up height influenced mechanical properties but its role is not fully understood yet. This paper presents the mechanical properties and microstructure of an IN 718 plate built using a EBF3 rotational build-up strategy through utilizing a forged plug in the center. The tensile properties of samples at the transition from forged to EBF3 material showed higher ductility and reduced strength than pure EBF3 material. This is likely due the influence of the forge material in one half of the specimen. Samples taken at approximately 15 degree increments from 0 to 90 degrees rotation to the DD in the additive portion of the plate were subjected to tensile testing. Along the build height, or the transverse direction (TD), the lowest strength was demonstrated and the TD aligned strongly to a <001> texture. Samples 45 degrees to the DD showed the greatest strength due to their preference for aligning to a <111> texture. Samples low on the build height demonstrated a higher strength than those on the top and displayed grain structures along the TD which were long, linear, and narrow across multiple deposition layers.
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Bennett, Kristi Lynn. "Methylation in head and neck squamous cell carcinoma." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1194544327.
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Ludenberg, Inga. "Regulation der B-Zell-Differenzierung anhand posttranslationaler Modifikationen von Ebf1 und Untersuchungen zur Redundanz von Ebf-Proteinen." Diss., Ludwig-Maximilians-Universität München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-160142.
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Ludenberg, Inga [Verfasser], and Daniel [Akademischer Betreuer] Krappmann. "Regulation der B-Zell-Differenzierung anhand posttranslationaler Modifikationen von Ebf1 und Untersuchungen zur Redundanz von Ebf-Proteinen / Inga Ludenberg. Betreuer: Daniel Krappmann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1038152631/34.
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Corradi, Anna. "Ebf2, a new regulator of neuronal differentiation : from gene identification to analysis of the Ebf2 -/- mouse." Thesis, Open University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342889.
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Kottman, Michael Andrew. "Additive Manufacturing of Maraging 250 Steels for the Rejuvenation and Repurposing of Die Casting Tooling." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1416854466.
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Hiechinger, Silvia. "Die Rolle von EBF2 in der haematopoietischen Stammzellnische." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-110169.
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Rochat, Joël. "Environnement de cross-développement libre pour ARM EBS3 /." Sion, 2007. http://doc.rero.ch/record/10781?ln=fr.
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Hinzen, Christoph. "The role of Ebf2 in normal and malignant hematopoiesis." Diss., Ludwig-Maximilians-Universität München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-178542.
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Luvizotto, Jessica. "Caracterização do filme radiocrômico GAFCHROMIC modelo EBT3 para uso em braquiterapia." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/85/85133/tde-19012016-132131/.
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A braquiterapia é a modalidade de tratamento radioterápico que utiliza fontes radioativas seladas a uma distância curta do tumor, diminuindo o risco de aplicação de uma dose indesejável em tecidos sadios adjacentes. Para que a braquiterapia seja confiável, é necessário estabelecer um programa de práticas dosimétricas visando a determinação da dose ideal de radiação para esta prática radioterápica. Neste trabalho apresenta a aplicação de duas metodologias destinadas à dosimetria utilizando filmes radiocrômicos. Medidas experimentais foram realizadas com filmes EBT3 em objetos simuladores composto de material homogêneo e heterogêneo (pulmão, osso e tecidos moles) construídos especialmente para medidas de dose em braquiterapia. Os processamentos e analises das imagens resultantes do procedimento experimental foram realizados com o software IMAGEJ e MATLAB. Os resultados foram avaliados a partir de comparações medidas experimentais de dose e obtidas por simulações pelo Método de Monte Carlo.Brachytherapy is a radiotherapy treatment modality using radioactive sealed sources within walking distance of the tumor, reducing the risk of applying an unwanted dose to adjacent healthy tissues. For brachytherapy is reliable, it is necessary to establish a dosimetric practices program aimed at determining the optimal dose of radiation for this radiotherapy practice. This paper presents the application of two methodologies for the dosimetry using radiochromic movies. Experimental measurements were performed with EBT3 movies phantoms consisting of homogeneous and heterogeneous material (lung, bone and soft tissue) built especially for dose measurements in brachytherapy. The processing and analysis of the resulting images of the experimental procedure were performed with ImageJ software and MATLAB. The results were evaluated from comparisons dose of experimental measurements and simulations obtained by the Monte Carlo method.
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LUVIZOTTO, JESSICA. "Caracterização do filme radiocrômico GAFCHROMIC modelo EBT3 para uso em braquiterapia." reponame:Repositório Institucional do IPEN, 2015. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26082.
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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2016-04-08T12:52:45Z
No. of bitstreams: 0Made available in DSpace on 2016-04-08T12:52:45Z (GMT). No. of bitstreams: 0
Dissertação (Mestrado em Tecnologia Nuclear)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Sabetti, Michela. "Controlli di qualita in radioterapia a fasci esterni con pellicole Gafchromic EBT3." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9434/.
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Il lavoro svolto per questa tesi è stato effettuato presso il reparto di Fisica Medica dell’Ospedale Bellaria di Bologna, e ha lo scopo di mettere in evidenza l’efficacia dell’utilizzo di pellicole Gafchromic EBT3 nei controlli di qualità effettuati sull’acceleratore lineare LINAC SynergyS per radioterapia a fasci esterni.
L’utilizzo continuo e prolungato dell’acceleratore durante i trattamenti radianti può causare nel tempo una perdita della calibrazione iniziale dei suoi componenti meccanici e dosimetrici: per questo è necessario controllarne periodicamente lo stato di funzionamento.
Lo scopo dei controlli di qualità è quindi quello di verificare che tale fenomeno non sia avvenuto, per garantire precisione e sicurezza durante l’irradiazione del paziente (essenziale per i trattamenti ad alta precisione come l’IMRT e il VMAT), richiedendo che il fascio erogato colpisca il tessuto malato e riducendo al minimo l’errore per evitare il danneggiamento dei tessuti sani circostanti.
I test effettuati sull’acceleratore lineare rientrano nel programma di assicurazione di qualità elaborato ed implementato a cura dei reparti di Fisica Medica e Radioterapia dell' Ospedale Bellaria di Bologna. Tale programma di assicurazione di qualità, è attuato per garantire che i risultati dei test rientrino nelle tolleranze meccaniche e dosimetriche previste dal protocollo dei controlli di qualità per le prove di stato e periodiche sull’acceleratore lineare in vigore all' AUSL di Bologna.
In particolare in questo lavoro di tesi sono state effettuate prove dosimetriche, quali la verifica dell’omogeneità e della simmetria del fascio radiante, e prove meccaniche quali la verifica della corrispondenza tra isocentro meccanico ed isocentro radiante.
Per queste verifiche sperimentali sono state utilizzate le pellicole radiocromiche Gafchromic EBT3; si tratta di dosimetri bidimensionali particolarmente adatti alla verifica dei trattamenti ad intensità modulata (IMRT, VMAT) che consentono un’accurata stima della distribuzione e dei gradienti di dose assorbita.
L'utilizzo delle pellicole Gafchromic EBT3 insieme al software FilmQA Pro si è rivelato uno strumento dosimetrico preciso, accurato e pratico per effettuare i controlli di qualità di base su un acceleratore lineare per radioterapia.
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Tzec, Quiñones Irving Ubaldo, and Cortes Jeanette Rodríguez. "Control de calidad en tratamientos de IMRT con película radiocrómica Gafchromic EBT3." Tesis de maestría, Universidad Autónoma del Estado de México, 2017. http://hdl.handle.net/20.500.11799/66163.
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Resumen
En la actualidad, la IMRT gana cada vez mayor aceptación y difusión para el tratamiento de cáncer, debido a las ventajas respecto a otras técnicas de tratamiento, como aumento de la dosis absorbida al tejido a irradiar y menor dosis al tejido circundante y órganos de riesgo. Sin embargo, debido a la naturaleza de la conformación de la dosis total, es común la formación de zonas de alto gradiente, por lo que es importante asegurar que el plan de tratamiento realizado con el sistema de planeación sea suministrado al paciente con la exactitud y precisión necesarias para cumplir con los parámetros de dosis absorbida y protección al tejido sano.
En este trabajo se evaluó la película radiocrómica EBT3 con miras a su utilización para el aseguramiento de la calidad en los tratamientos de radioterapia con la técnica IMRT en el Hospital General de México. Para esto se compararon las distribuciones de dosis en un plano medidas con estas películas y con las películas radiográficas EDR2, con los datos calculados por el sistema de planeación, utilizando el índice gamma como criterio de evaluación. Se estudiaron los planes de nueve pacientes, para lo cual se caracterizaron las curvas de calibración correspondientes a cada tipo de película, se realizaron mediciones de dosis puntuales con cámara de ionización, y se realizó el análisis gamma con criterios de 3%/3 mm, 4%/3 mm y 5%/3 mm para la diferencia de dosis y la distancia en concordancia.
El 100% de las distribuciones medidas con las películas radiocrómicas tuvieron un porcentaje de puntos con γ<1 mayor al 90% con el criterio de 3%/3 mm, mientras que dos tercios de los planes analizados con las películas radiográficas cumplieron con esta restricción. Las mediciones con cámara de ionización mostraron una diferencia entre la dosis medida y calculada menor al 3% en ocho de los nueve planes analizados.
Los resultados indican que las películas radiocrómicas EBT3 son adecuadas para el análisis de distribución de dosis en el control de calidad paciente especifico en tratamientos de IMRT en la institución.
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Maleka, Sechaba. "Targeting the EBFR and PI3K pathways as a therapeutic strategy for prostate cancer." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96854.
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Thesis (MSc)--Stellenbosch University, 2015.ENGLISH ABSTRACT: Targeted therapy for prostate cancer may offer potential improvement over current conventional therapies because of its specificity. Although conventional treatments are effective, they are not curative and have several limitations. In prostate cancer, activation of both the epidermal growth factor receptor (EGFR) and the phosphatidylinositol 3 – kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway have been implicated in tumorigenesis and resistance to both conventional and targeted anticancer therapies. Having a better understanding of the molecular mechanisms involved in PCa development, progression and resistance to therapy, could assist in the design of novel therapeutic strategies. The objective of this study was to inhibit key molecular targets of the human epidermal growth factor receptor signalling pathway and expose prostate cell lines to doses of radiation, so as to establish potential therapeutic targets that may be amenable to combined modality therapy, and formulate a cocktail of inhibitors to evaluate its radiosensitising capability. The EGFR/PI3K/mTOR pathway plays an important role in the radiosensitivity of the human prostate carcinoma cell line (DU145) and the normal cell line (1542N). In our study we have shown that AG-1478, an EGFR inhibitor, and BEZ-235, a dual inhibitor of the PI3K/mTOR pathway, singly or in combination, at low and relatively high radiation doses, resulted in radiosensitisation of DU145 cells. Radio-protection was achieved in 1542N cells. AG-1478 had no effect on radiosensitivity.
AFRIKAANSE OPSOMMING: Geteikende terapies wens hul spesifisiteit teenoor konvensionele terapies vir prostaat kanker, mag potensieel verbetering offer. Konvensionele behandeling is wel effektief maar nie genesend nie wens ‘n aantal beperkings, sowel as die toksisiteit vir normale selle. In prostaat kanker is die aktivering van beide die epidermiese groei faktor reseptor (EGFR) en fosfatidielinositol 3-kinase/Akt/soogdier teiken vir rapamisien (mTOR) seingewing baan sterk betrek by tumor groeisel en weerstand teen konvensionele en geteikende anti-kanker terapies. Beter begrip van die molekulêre meganismes betrokke by prostaat kanker ontwikkeling, bevordering en weerstand teen terapie, kan die ontwerp van nuwe terapeutiese strategies ondersteun. Die doelwit van hierdie studie was om sleutel molekulêre teikens van die epidermiese groei faktor reseptor seingewing baan te inhibeer en om prostaat selle bloot te stel aan dosisse bestraling, om potensiële terapeutiese teikens te vestig wat vatbaar is vir gekombineerde modaliteit terapie, om ‘n mengsel van stremmiddels te formuleer, en om die straling gevoeligmaking bekwaamheid daarvan te evalueer. Die EGFR/PI3K/mTOR seingewingbaan speel ‘n belangrike rol in the radiosensitiwiteit van die menslike prostaat kanker sellyn (DU145) en die normale prostaat sellyn (1542N). Die studie bevind dat AG-1478, ‘n EGFR stremmer, en BEZ-235, ‘n tweevoudige beperker van die fosforinositied 3-kinase (PI3K) en soogdier teiken vir rapamisien (mTOR) seingewingbaan, enkel of in kombinasie die DU145 selle radiosensitiseer vir straling dosisse van 2 en 6 Gy. Stralings beskerming was verkry met die 1542N sellyn. AG-1478 het geen effek getoon op radiosensitiwiteit nie.
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Bergström, Madeleine. "Skin dose measurement during radiation therapy of mastectomy patients using GafChromicTM EBT3 films." Thesis, Linköpings universitet, Institutionen för medicinsk teknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-144289.
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Purpose: The aim of this study was to develop a method of measuring changes in the skin microcirculation and skin dose for mastectomy patients in connection with the radiation treatment. The distribution of the skin dose, its dependence on the energy of the beam, field geometry and bolus material and the accuracy of the given skin dose in the treatment planning system were studied. Finally, the correlation between the given dose and the changes in skin microcirculation was evaluated. Methods: Skin dose was measured using GafChromic EBT3 films. To evaluate the impact of different energies and field geometry measurements on a PMMA phantom were done. Dose measurements were done using an anthropomorphic phantom and in patients. The measured skin doses were compered to the doses calculated using the treatment planning system. Before and after treatment, skin blood perfusion was measured using laser speckle contrast imaging. In connection with the last measurement also methyl nicotinate was used to increase the perfusion for the measurement. Results: The measurements on the PMMA-phantom indicate that a larger photon energy results in a lower dose to the skin, but a higher exit dose. Furthermore a more oblique angle results in a higher skin dose and a larger field size also results in an increased skin dose. The patient measurements showed that the skin dose was significantly different in different areas of the irradiated field. The highest dose was measured in the area in which a bolus was applied. All patients showed a significant increase in skin blood of the perfusion within the irradiated area. The comparison between the measured doses and the doses calculated using the treatment planning system shows an underestimation of the skin dose by the treatment planning system depending on the incident angle and the presence of bolus material. Conclusion: The distribution of the skin dose during breast cancer radiotherapy in mastectomy patients is heterogeneous with the highest dose in the area of the mastectomy scar, due to the presence of bolus material. A correlation can be noticed between the changed in microcirculation and the radiation dose to the skin. Estimation of the skin dose using the treatment planning system is inaccurate, but film doseimetry offers an easy-to use method to accurately measure the dose to different areas of the irradiated skin.
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Martínez, Quiroz Cesar Alejandro. "Análisis de la no uniformidad de películas radiocrómicas EBT3 mediante espectroscopia de absorción." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2017. http://hdl.handle.net/20.500.11799/68405.
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Las PR EBT3 presentan una falta de uniformidad en su capa activa que llega a ser de un 2.2% antes de ser irradiadas, este fenómeno de no uniformidad de las PR EBT3 se atenúa después de irradiar las películas disminuyendo hasta un 1.4% en la zona de interés dosimétrico correspondiente al canal rojo de 636 nm.
Se puede observar que la falta de uniformidad en la capa activa de la PR EBT3 es menor cuando esta es irradiada, esto se puede atribuir a que un campo de radiación homogénea tiende a producir una densidad de polímeros homogénea.
El espectrofotómetro es más sensible a la falta de uniformidad en la capa activa de las PR EBT3 proporcionando valores más apegados a la realidad de este fenómeno. La falta de uniformidad que presenta la capa activa de las PR EBT3 debe considerarse en la determinación de la dosis, ya que en un tratamiento convencional de radioterapia la incertidumbre total debe ser menor al 5% (28) y en uno de radiocirugía menor al 2% .Actualmente, las películas radiocrómicas se han convertido en una herramienta útil para la determinación de la dosis y el control de calidad en los tratamientos de radioterapia, esto se debe a características que presenta, como la alta resolución espacial, tejido-equivalencia y que no requieren proceso químico posterior. Sin embargo, se ha reportado una falta de uniformidad de algunos casos de 1.5%(4,5) en la capa activa de la película que influye directamente en la incertidumbre de la determinación de la dosis. Por lo tanto, es de gran importancia el estudio y cuantificación de la no-uniformidad de la PR EBT3.
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Kim, Jeehee. "Biological role and genetic redundancy within the ebf gene family." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-182813.
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Rossi, Eleonora. "Dosimetric characterization of GafChromic EBT3 films in Volumetric Modulated Arc Therapy (VMAT) radiotherapy treatments." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14245/.
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Questo lavoro di tesi, svolto presso l'Unità Operativa di Radioterapia dell'Ospedale Bellaria di Bologna, si pone l'obiettivo di caratterizzare dosimetricamente i film radiocromici GafChromic EBT3 al fine di implementarne l'utilizzo clinico nell'ambito dei controlli di qualità su piani di trattamento radioterapici VMAT (Volumetric Modulated Arc Therapy). I controlli di qualità per trattamenti VMAT sono attualmente effettuati grazie ad un sistema fantoccio-detector a camere a ionizzazione, Octavius 4D, in grado di ricostruire in maniera accurata la distribuzione di dose tridimensionale depositata su tutto il volume del fantoccio stesso. Nonostante ciò, la risoluzione spaziale offerta da questo strumento è limitata in particolari casi in cui è necessario conoscere la distribuzione di dose rilasciata ai tessuti con precisione inferiore a qualche millimetro, mentre il punto di forza della dosimetria a film risiede proprio nella elevata risoluzione spaziale. Con il seguente lavoro abbiamo voluto testare le pellicole EBT3 nella pratica della dosimetria clinica su piani altamente modulati come i VMAT, osservando la risposta del film rispetto a quella del sistema Octavius procedendo per crescenti livelli di difficoltà dei piani irradiati, per consolidare la procedura sperimentale. Abbiamo osservato che, in termini di indice gamma, il più usato per comparare quantitativamente mappe di dose, il passing rate nel confronto tra piani di trattamento calcolati e misurati con il sistema Octavius è del 100% per proiezioni bidimensionali e del 99.7% su ricostruzioni tridimensionali (entro limiti descritti dettagliatamente nel paragrafo 3.1). I film invece raggiungono in un solo caso un passing rate superiore al 95%, soglia di accettabilità nella pratica clinica. Tuttavia, è stato possibile mostrare l'efficacia dei film nella ricostruzione di profili di dose accurati, evidenziando la loro superiorità in risoluzione spaziale rispetto alla tecnica dosimetrica correntemente impiegata.
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Hinzen, Christoph [Verfasser], and Berit [Akademischer Betreuer] Jungnickel. "The role of Ebf2 in normal and malignant hematopoiesis / Christoph Hinzen. Betreuer: Berit Jungnickel." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/106518039X/34.
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Chiara, F. "Role of early B-cell factors (EBFs) in the development of the cerebral cortex." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1317734/.
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Early B-cell factor 2 (Ebf2) is one of four mammalian members of the helix-loophelix transcription factor family Collier/Olf/Ebf (COE). COE proteins EBF1, EBF2 and EBF3 have been implicated in various aspects of neural development including neurogenesis, cell differentiation, neuronal migration and axonal fasciculation. Here, I examined the role of one of these proteins, EBF2, on the development of the cerebral cortex. Ebf2 mRNA, detected by in situ hybridisation, was transiently expressed in the developing mouse cerebral cortex. In particular, it was found in the cortical hem, septum and preplate/marginal zone, which are known sites of origin and migration for Cajal-Retzius cells, respectively. In order to permanently label Ebf2 positive cells even after the downregulation of the gene expression, the transgenic line Ebf2GFPiCre was crossed with the reporter line Rosa26RYFP. It was found that the expression of Ebf2 matched the expression of markers for Cajal-Retzius cells, subplate cells and a subpopulation of layer V pyramidal neurons. Although Ebf2-/- mice showed a delay in the migration of Cajal-Retzius cells at early stages of development, which was rescued by the end of gestation, they did not present any other gross defect in cortical topography and cellular organisation. In vivo and in vitro studies have suggested that Ebf1 and Ebf3, also expressed in the cortical hem and septum, may be involved in complementing the lack of Ebf2 function. These results suggest a role for the EBF family in controlling Cajal-Retzius cell development.
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Dias, Dos Santos Sheila. "Molecular mechanisms of early B cell differentiation : the role of Interleukin-7." Paris 6, 2005. http://www.theses.fr/2005PA066131.
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Abu, El-Madg Mohammed El-Sayed Rizk. "The function and regulation of chick Ebf genes in somite development." Thesis, Royal Veterinary College (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522148.
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Kim, Young-Jin. "Impacts of evaluation-based funding (EBF) on academic work : Korean perspectives." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440265.
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Mazza, Alessandro. "Set up of a procedure for correlation analysis between current discharge and dose delivery in a pulsed power plasma device for medical application." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/10233/.
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This thesis work aims to find a procedure for isolating specific features of the current signal from a plasma focus for medical applications. The structure of the current signal inside a plasma focus is exclusive of this class of machines and a specific analysis procedure has to be developed. The hope is to find one or more features that shows a correlation with the dose erogated. The study of the correlation between the current discharge signal and the dose delivered by a plasma focus could be of some importance not only for the practical application of dose prediction but also for expanding the knowledge anbout the plasma focus physics. Vatious classes of time-frequency analysis tecniques are implemented in order to solve the problem.
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Wang, Qiongman [Verfasser], and Dirk [Akademischer Betreuer] Eick. "Regulation of B cell development by posttranslational modification of Ebf1 / Qiongman Wang ; Betreuer: Dirk Eick." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1117474240/34.
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Archambault, Laurie. "Validation of XiO's electron Monte Carlo module using GafChromic EBT3 films and triple channel dosimetry." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114541.
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Treatment planning in radiation therapy is based on the calculation of dose distributions, aimed at best representing the physical dose distributions. The most promising avenue towards this goal is the Monte Carlo technique, whereby particle trajectories are simulated from a modelled radiation source into a patient volume. Following the trend of incorporating fast Monte Carlo algorithms in clinical electron beam dosimetry, Elekta CMS inc. commercialized an electron Monte Carlo (eMC) module implemented in the treatment planning system XiO. The algorithm is based on the XVMC code and allows for fast calculations in voxelized heterogeneous media. This thesis reports its validation as a first step towards clinical implementation for an Elekta SL25 linear accelerator. Simulations with the eMC module were performed for 12 MeV beams in different CT scanned phantoms and beam setups. Concurrently, GafChromic® EBT3 film measurements were performed and the two dose distributions were compared, using mainly three-dimensional gamma agreements. Film measurements were analysed through a novel method using the triple channel dosimetry function of Film QA Pro, thus yielding absolute dose readings with an uncertainty of ±1.5% over the range of [75, 700] cGy. The results indicate that beam models generated by CMS should be validated prior to any more complex investigation as they strongly impact on the accuracy of dose distributions. Provided that the beam models are valid, the comparisons are very promising : a 2%/3 mm agreement was found between measurements and calculations at different depths in a three-dimensional heterogeneous phantom.La planication de traitements en radiothérapie est basée sur des calculs de distributions de dose visant à reproduire les distributions réelles. À cet effet, la méthode Monte Carlo simulant les trajectoires des particules et la déposition de dose à partir d'une source de radiation modélisée s'avère des plus prometteuses. Suivant le mouvement d'intégration clinique des méthodes Monte Carlo dites rapides pour les traitements par électrons, la compagnie Elekta CMS inc. a commercialisé un module électron Monte Carlo (eMC) implémenté dans le système de planification de traitement XiO. L'algorithme est basé sur le code XVMC et permet d'effectuer des calculs rapides de la dose dans des milieux hétérogènes voxelisés. Ce mémoire rapporte une première étape de l'implémentation clinique de l'algorithme pour un accélérateur Elekta SL25. Des simulations eMC ont été effectuées pour des faisceaux de 12 MeV dans différents fantômes et conditions d'irradiation. Parallèlement, des mesures ont été réalisées à l'aide de films GafChromic® EBT3 et les distributions de dose ont été comparées grâce à outil de comparaison gamma 3D. Les films ont été analysés via unenouvelle méthode employant la technique de dosimétrie à trois canaux de Film QA Pro. Celle-ci fournit des lectures de dose absolue entre 75 et 700 cGy avec une incertitude de ±1.5%. Les résultats indiquent que les modèles de faisceaux générés par CMS ont un impact considérable sur les distributions de dose ; ainsi, ils doivent être validés en premierlieu. Lorsque les faisceaux soient bien modélisés, les comparaisons de dose obtenues sont prometteuses : un accord de 2%/3 mm entre les mesures et les calculs a été déterminé à différentes profondeurs dans un fantôme hétérogène complexe.
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Molina, Romero Marisol. "Propiedades dosimétricas de las películas de tinte radiocrómico EBT3 irradiadas con electrones de alta energía." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2017. http://hdl.handle.net/20.500.11799/66087.
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La capacidad de hacer dosimetría en dos dimensiones es una herramienta para la medicina. En particular, en la terapia de irradiación de cuerpo entero con electrones de alta energía, utilizada para el tratamiento de la micosis fungoide, se debe determinar, de manera adecuada y en un tiempo razonablemente corto, el porcentaje de dosis en profundidad y la distribución de dosis en el plano del tratamiento (80 x 190 cm2), para ello se pueden usar diferentes dosímetros tales como las cámaras de ionización (CI), las películas de tinte radicrómico o
radiocrómicas (PTR) y los dosímetros termoluminiscentes (TLD), entre otros. Sin embargo usar CI o TLD, es bastante tardado y requiere de un sistema de control de movimiento para tener mayor precisión, de ahí que la película radiocrómica es una alternativa para medir el campo de radiación ya que cuenta con las características de ser relativamente barata, archiva los datos adquiridos al ser irradiada y es sensible a la radiación.
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De, la Cruz Pérez Diego. "Estudio de la Generacion de Bandas de Interferencia Fabry-Perot en las Peliculas Radiocromaticas EBT3." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2017. http://hdl.handle.net/20.500.11799/68434.
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Se observaron bandas adicionales a las que presentan los espectros de absorción neta de las PR EBT2, en los espectros de absorción neta de las películas radicromicas EBT3.
Proponiendo un modelo de interferometro de Fabry-Perot, donde las caras de las películas radicromicas actúan como espejos y la capa activa de estas películas compuesta principalmente de polidiacetilenos como una cavidad resonante, se logro la reproducir las bandas presentes en el espectro de absorcion neta de las PR EBT3.En los últimos años, el uso de las películas radiocrómicas (PR) se ha incrementado considerablemente, convirtiéndose en una herramienta importante en los tratamientos de radioterapia. Las PR, han sido diseñadas para cubrir las necesidades dosimétricas tanto en la verificacion de la dosis, como en los procedimientos de control de calidad. Cuando las PR interactuan con la radiación ionizante presentan un cambio de color que se cuantifica con la magnitud física denominada densidad óptica. Por lo tanto, las PR requieren de un sistema optico para leerlas.
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Barreto, Suzana Maria. "Towards autonomous sample positioning for ultra high vacuum chambers." Thesis, Aberystwyth University, 2018. http://hdl.handle.net/2160/77e7f40d-eb63-4062-bc1f-e5e4e7d102a9.
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Materials Science has in recent years become a high priority research area, having been identified as a growth sector for the UK economy over the next decade. Breakthroughs in this field are likely to have a significant impact on every area of our lives. There has recently been a trend toward automation at beamlines which is driven by rapid technology advancement. This technology advancement has improved the quality of experiment data and has allowed data collection times to improve exponentially. The Materials Science Research Group in the Institute of Mathematics, Physics and Computer Science, at Aberystwyth University have achieved international recognition for their research on materials under extreme conditions. They have a rich history in the development and use of specialist instruments to conduct real time surface analysis. Their custom made instrumentation has allowed them to greatly improve experiment throughput. Automation of the group's ultra high vacuum chambers is therefore a further enhancement that is advantageous, important, necessary and inevitable. This thesis presents the research undertaken to study what is required to provide automated sample positioning inside vacuum chambers that are operated under ultra high vacuum conditions, as the first step towards automation. As part of the research, a prototype automated positioning system that employs state of the art model based visual tracking techniques was developed to gain an understanding of the challenges the ultra high vacuum environment presents. Experimentation was carried out to assess the effects of different lighting conditions on tracking, evaluate the tracking library, extract suitable extrinsic parameters for tracker initialisation, and evaluate both monocular and stereo mode tracking. Key findings were that the model based tracking is a suitable approach for an automated positioning system but that performance depends on having suitable port placement for the cameras. Stereo tracking provided the best performance but was still prone to divergence at certain relative positions of the manipulator. On linear runs the average error was 0.06mm. On rotational runs, anti-clockwise runs proved better with an average error of 2o to 3o. The high errors of mixed rotational and linear tracking runs did not match the visual outputs indicating that there were inherent errors in the data evaluation. Tracking output video footage is available at [8]. More work is needed to take the system forward and close the tracking loop. Recommendations for improvements were provided.
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Grant, Sean Patrick. "Development of a CONSORT extension for social and psychological interventions." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:c1bd46df-eb3f-4dc6-9cc1-38c26a5661a9.
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Background: Defined by their mechanisms, social and psychological interventions are those interventions that work through mental processes and social phenomena. They are often complex and challenging to evaluate, so understanding randomised controlled trials (RCTs) of these interventions requires detailed reports of the interventions tested and the methods used to assess them. However, reports of these RCTs often omit important information. Poor reporting hinders critical appraisal and synthesis of RCTs in systematic reviews, thereby impeding the effective transfer of research evidence to policy and practice. The Consolidated Standards for Reporting Trials (CONSORT) Statement is a reporting guideline that has contributed to improvements in the quality of RCT manuscripts in journals publishing medical research. However, studies have shown persistent deficiencies in the reporting quality of social and psychological intervention trials. A new CONSORT extension for these interventions may be needed given their distinct and complex features. This DPhil thesis reports on a project to develop and disseminate an official CONSORT Extension for Social and Psychological Interventions: CONSORT-SPI. Structure: Following a preface, this DPhil thesis includes eight chapters. Chapter 1 provides an overview of the conceptual rationale that prompted the CONSORT-SPI project. Chapter 2 details the project protocol, which consists of a five-phase methodology that follows current best practices for reporting guideline development and dissemination. Chapter 3 discusses systematic literature reviews to assess reporting guidelines for and the reporting quality of publications of social and psychological intervention RCTs. Chapter 4 discusses an online, international Delphi process to generate a prioritised list of possible items to include in the CONSORT-SPI extension. Chapter 5 discusses a formal consensus meeting to select reporting items to add to or modify for the CONSORT-SPI Extension checklist. Chapter 6 involves drafts of the CONSORT-SPI checklist as well as a template for the Explanation and Elaboration (E&E) document providing detailed advice and examples of good reporting for each checklist item. These drafts have not yet been circulated to co-authors or other members of the project team; their purpose in this thesis is to give an indication of how previous project phases have led into initial prototypes of the checklist and E&E, which will undergo further development and revision by the project team before publication. Chapter 7 proposes a coordinated dissemination and implementation strategy informed by theoretical frameworks and tools used to guide the implementation of clinical guidelines and empirically-supported interventions. The final chapter summarises the information gained from the CONSORT-SPI project to date, assesses strengths and limitations of the project methodology, and discusses implications for future research. Conclusion: A CONSORT-SPI Extension could improve the reporting quality of social and psychological intervention RCTs. This extension could also facilitate better critical appraisal of this body of research and its use in evidence-based decision-making. With successful dissemination and implementation, the guideline will hopefully contribute to the improvement of intervention evaluations—as well as the methodology underpinning these studies—within the social and behavioural sciences.
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Huntley, James Seymour. "Vibro toxins : perturbations of membrane function." Thesis, University of Oxford, 1994. http://ora.ox.ac.uk/objects/uuid:201b4c22-eb53-4214-8f67-76acfb82d6f5.
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Many bacterial toxins are important virulence factors, capable of instigating marked changes in the physiology of susceptible cells and tissues. Mechanisms of membrane attack by Vibrio toxins were examined on target cells, using cell physiological techniques, in particular, assays of haemolysis and radioisotope movement. Kanagawa haemolysin (KH; commercially available preparation of the thermostable direct haemolysin (TDH)) of V. parahaemolyticus caused lysis of human (but not horse or hagfish) erythrocytes that occurred (a) after colloid osmosis due to raised cation permeability, (b) independently of the KH:red cell ratio, and (c) with a monovalent cation selectivity series (reversed Eisenman VIII with a small K+ anomaly). The binding phase of KH was longer than the 1 - 2 minutes suggested by other workers. The KH-induced cation leak was (a) rapid in onset, (b) of a magnitude higher in the first ten minutes of treatment than subsequently, (c) of a multi-hit nature, (d) unaffected by a variety of membrane-active agents, and (e) inhibited by Zn2+, Cd2+ or mixing of toxin with dibutyl phthalate. Neuraminidase treatment of HRBC enhanced KH-induced cation influx and haemolysis, suggesting that additional receptors for TDH were unmasked by this treatment. In the presence of subhaemolytic KH, physiological levels of extracellular Ca2+ increased K+ influx by the Gardos channel, and Mg2+ (1.5 mM) decreased flux by the Na+/KV2Cr cotransporter. There were no significant changes to sodium pump activity. TDH and El Tor haemolysin (ETH) were purified from culture supernatants of V. parahaemolyticus and non-Ol V. cholerae, respectively. Highly purified TDH was derived from KH and used to confirm that the identified features of KH action were attributable to TDH. Although ETH also caused haemolysis by colloid osmosis secondary to increased cation permeability, it differed from TDH in its lability to air/vibration, relative magnitude of induced influx with respect to time, and selectivity series of induced lesion. Concentrated supernatants, from V. cholerae strains deleted of known virulence factors, caused morphological changes of Chinese hamster ovary cells, suggesting the presence of unidentified factors capable of perturbing cell physiology. Confirming its potential as an enterotoxin, KH (albeit at a high dose) increased the efflux rate constant for 86Rb+ from rabbit jejunocytes. These findings are discussed in the context of a possible pathogenic role for TDH in the gastrointestinal tract.
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Hutton-Smith, Laurence. "Modelling the pharmacokinetics and pharmacodynamics of macromolecules for the treatment of wet AMD." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:5c6d908f-ebf1-4006-8666-862a17c3f799.
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Wet age related macular degeneration (wet AMD) is a highly debilitating retinal disease, the third leading cause of blindness in the world and one the most expensive ocular conditions to care for. Wet AMD is characterised by the proliferation of neovasculature through the retinal posterior and theorised to be, at least in part, induced and driven by excess vascular endothelial growth factor (VEGF). Many current treatments for wet AMD utilise anti-VEGF macromolecules that bind to VEGF. The retina, however, remains a largely inaccessible, and delicate, anatomical region. Due to difficulties in collecting clinical and experimental data, mathematical modelling is playing an increasingly prominent role in understanding the distribution (Pharmacokinetics, PK) and drug-to-target interactions (Pharmacodynamics, PD) for treatments of wet AMD. This thesis will focus on ordinary/partial differential equation (ODE/PDE) models for the PK/PD of anti-VEGF therapeutics, administered via intravitreal (IVT) injection into the mammalian eye. We start in Chapter 2 with a 2-compartment PK/PD ODE model of drug-VEGF interactions in the eye, analysing a clinical dataset to estimate key binding parameters between VEGF and the typical anti-VEGF molecule, ranibizumab. In Chapter 3, we extend the PK ODE framework of the 2-compartment model to include a mechanistic description of the retina, to estimate retinal permeability to macromolecules used for treating wet AMD. In Chapter 4, using the retinal PK model, we reintroduce VEGF to predict concentrations of free VEGF in the retina post-IVT injection. Chapters 5 and 6 model a hypothetical class of anti-VEGF molecules designed to bind not only VEGF but also existing vitreal superstructures, analysing how dose and binding kinetics impact ocular retention. Alongside these models we present analogous PDE models, addressing whether the assumption that concentrations are homogeneous across anatomical regions, as implicit in ODE models, is appropriate for macromolecular PK/PD in the mammalian eye.
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Cooper, Merlin Frederick Wilmot. "Measurement and manipulation of quantum states of travelling light fields." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:79164748-ebb3-48e2-b4d4-1a4766d29217.
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This thesis is concerned with the generation of non-classical quantum states of light, the photon-level manipulation of quantum states and the accurate tomography of both quantum states and quantum processes. In optics, quantum information can be encoded and processed in both discrete and continuous variables. Hybrid approaches combining for example homodyne detection with conditional state preparation and manipulation are gaining increasing prominence. The development and characterization of a time-domain balanced homodyne detector (BHD) is presented. The detector has a bandwidth of 80 MHz, a signal-to-noise ratio of 14.5 dB and an efficiency of 86% making it well-suited to pulse-to-pulse measurement of quantum optical states. The BHD is employed to perform quantum state tomography (QST) of non-classical multi-photon Fock states generated by spontaneous parametric down-conversion. A detailed investigation of the mode-matching between the local oscillator used for homodyne detection and the generated Fock states is presented. The one-, two- and three-photon Fock states are reconstructed with a combined preparation and detection efficiency exceeding 50%. Fock states have a number of applications in quantum state engineering, where non-classical ancilla states and conditional measurements enable photon-level manipulation of quantum states. Fock state filtration (FSF) is investigated - an example of a post-selected beam splitter which is a basic building block for many quantum state engineering protocols. A model is developed incorporating the effect of experimental imperfections. An experimental implementation of a Fock state filter is fully characterized by means of coherent-state quantum process tomography (QPT). The reconstructed process is found to be consistent with the model. The filter preferentially removes the single-photon component from an arbitrary input quantum state. Calibration of optical detectors in the quantum regime is discussed. Quantum detector tomography (QDT) is reviewed and contrasted with a new technique for performing QST with a calibrated detector known as the fitting of data patterns (FDP). The first experimental characterization of a BHD is performed by probing the detector with phase-averaged coherent states. The FDP method is shown to be applicable to the estimation of quantum processes, where a detector response is not assumed - thus demonstrating the versatility of the FDP approach as a new method in the quantum tomography toolbox.
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Sahlström, Leena. "Linking exposure pathways to internal concentrations of brominated flame retardants in Swedish mothers and their toddlers." Doctoral thesis, Stockholms universitet, Institutionen för tillämpad miljövetenskap (ITM), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-107592.
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Brominated flame retardants (BFRs) have been used in a variety of consumer products to enhance their fire safety. This has resulted in exposure of the environment, wildlife and humans causing risks of endocrine disruption. The use restrictions of many BFRs have resulted in the introduction of other brominated chemicals (emerging BFRs) on the market. Humans are exposed to BFRs primarily via diet and dust ingestion, but the importance of the different exposure pathways has scarcely been studied. Children in particular have not been studied well due to lack of biomonitoring data. In this thesis, a mother-toddler cohort (n=24) from Uppsala was studied for their exposure to tri-decabrominated diphenyl ethers (tri-decaBDEs), isomer-specific hexabromocyclododecanes (HBCDs) and emerging BFRs (EBFRs). A clean-up and fractionation method was developed for determination of the above-mentioned BFRs in the same sample without dividing the sample. Measures of external exposure from dietary intake and dust ingestion were estimated. These were compared to internal concentrations (serum, feces) to determine which exposure pathways were most important for explaining the different BFR concentrations and patterns found in mothers and toddlers. Taking all the results into account, the toddlers’ higher serum levels of tetra-pentaBDEs seem to be the result of previous breastfeeding and those of octa-decaBDEs from exposure to house dust. For mothers, diet was estimated to be the main exposure route of tri-hexaBDEs and HBCDs. Dust ingestion was estimated to be the main route for BDE-209 exposure in mothers. Significant correlations were found between the tetra-decaBDE concentrations in matched serum and feces samples indicating that feces could be used as a non-invasive sample matrix for biomonitoring of PBDEs in toddlers. EBFRs were detected in the feces of toddlers and in a few serum samples from both mothers and toddlers indicating that exposure to these replacement chemicals occurs.At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: Submitted. Paper 4: Manuscript.
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LEON, MARROQUIN ELSA YAZMIN 473018, and MARROQUIN ELSA YAZMIN LEON. "Caracterización y validación de la película Gafchromic EBT3 para control de calidad en tratamientos de radiocirugía utilizando dos sistemas ópticos." Tesis de doctorado, Universidad Autónoma del Estado de México, 2016. http://hdl.handle.net/20.500.11799/65470.
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En los últimos años, se han desarrollado técnicas de RT para mejorar la dosis suministrada al blanco, mientras se reduce la dosis a los tejidos circundantes. Esto permite que la entrega de los tratamientos de RT se ajustan con mayor exactitud a la región blanco de irradiación. La dosimetría en los tratamientos de RC puede ser complicada e inexacta debido los altos gradientes de dosis que los caracteriza, por lo que es necesario un detector con alta resolución espacial. Por otro lado, las PR son detectores bidimensionales que, además de la alta resolución espacial, presentan equivalencia a tejido, proceso de autorrevelado, independencia con la tasa de dosis, poca dependencia con la energía en el intervalo de megavoltaje y técnicas de bajo costo para la lectura usando escáneres de documentos. El sistema dosimétrico formado por la PR y el escáner permite la dosimetría bidimensional en un amplio intervalo de dosis (utilizando los tres canales de color, rojo, verde y azul) muy útil para la verificación de la dosis y el control de calidad en los tratamientos de RC. Sin embargo, este sistema dosimétrico tiene algunos inconvenientes como son la dependencia con la orientación relativa película-escáner, la falta de uniformidad en el área útil de escaneo, los parámetros de escaneo, la estabilidad del escáner, la incertidumbre del escáner y la curva de calibración. Todos estos factores se han estudiado y considerado en la evaluación de los planes de tratamiento para tener una dosimetría que cumpla con los requerimientos de control de calidad de los tratamientos en RC. El desempeño de los modelos de PR EBT y EBT2 ha sido ampliamente estudiado y reportado. La mayoría de los estudios sobre la caracterización y el uso de las PR EBT y EBT2 se realizaron con los datos proporcionados por el canal rojo de un escáner comercial en PR irradiadas hasta 8 Gy basándose en las características espectrales de la PR, ya que el espectro de absorción de estos modelos de PR presentan una banda de absorción de máxima sensibilidad en 636 nm. Sin embargo, en los tratamientos de RC se entregan dosis de radiación mayores a 12 Gy y, por la naturaleza de la técnica del tratamiento, requiere de un alto control de calidad. Por lo tanto, es necesario un estudio riguroso de las características del sistema dosimétrico para dosis mayores a 8 Gy, ya que la falta de información puede 23 impedir la precisión y exactitud en el cálculo de la determinación de la dosis y/o, como consecuencia, afectar el control de calidad del tratamiento. Además, se han encontrado pocos estudios sobre la caracterización de la PR EBT3, ya que se asume que el comportamiento dosimétrico es similar que el de la PR EBT2, basándose en el hecho de que la PR EBT3 conserva la composición de la capa activa de su predecesora, la PR EBT2.La radiocirugía (RC) es un procedimiento que consiste en el depósito de altas dosis de radiación ionizante en una sola sesión a blancos específicos, cuya dosis de prescripción depende de la patología a tratar y la protección a los órganos de riesgo circundantes. Debido a que este procedimiento deposita altas dosis de radiación ionizante (>12 Gy) en volúmenes de dimensiones reducidas (<3 cm) es necesario tener alta exactitud mecánica y dosimétrica durante el tratamiento, pues cualquier imprecisión en la determinación de la dosis magnífica el riesgo de complicaciones en tejido sano. Por lo tanto, los campos empleados en RC requieren, para su caracterización y comisionamiento, dosímetros con alta resolución espacial. La película radiocrómica (PR) juega un papel importante en RC debido a su alta resolución espacial. La PR ha sido diseñada para satisfacer las necesidades de la dosimetría en radioterapia (RT). Además, presenta otras características que las hacen útiles en estos casos, tales como: equivalencia a tejido, poca dependencia con la energía de megavoltaje y fácil manejo en clínica (ya que no requieren procesamiento de revelado y tiene poca sensibilidad a la luz UV), pueden sumergirse en agua y su respuesta es independiente a la tasa de dosis. Entre las novedades que presenta la nueva película, EBT3, está su construcción simétrica y un revestimiento anti anillos de Newton para una mayor facilidad de uso y precisión, sin embargo, la composición química de la capa activa no cambia con respecto a la PR EBT2. Otra característica de la PR que la hace factible para dosimetría en RT es que las técnicas para su análisis son de bajo costo al utilizar escáneres de documentos. Sin embargo, cuando se realiza dosimetría relativa con PR y escáner existen muchas fuentes de incertidumbre cuando convertimos la respuesta de la película (densidad óptica neta, DOneta) a dosis. Estas fuentes de incertidumbre se deben estudiar y cuantificar para minimizar su contribución a la incertidumbre total en la determinación de la dosis, entre ellas se encuentran falta de uniformidad de la respuesta de la película, la reproducibilidad de la respuesta en la película, la dependencia con la orientación relativa película-escáner, la reproducibilidad en la respuesta del escáner, la falta de uniformidad en la respuesta del 10 escáner, los parámetros de escaneo, la estabilidad del escáner, la determinación del intervalo dinámico de la película, la resolución del sistema y la curva de calibración. Para un tratamiento de RT, la incertidumbre total en la deposición de la dosis no debe ser mayor del 5%, por lo tanto, la incertidumbre total en la determinación de la dosis para el sistema dosimétrico con PR es mayor que 3.3
UAEMéx
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Kim, Jeehee [Verfasser], and Barbara [Akademischer Betreuer] Conradt. "Biological role and genetic redundancy within the ebf gene family / Jeehee Kim. Betreuer: Barbara Conradt." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1073825779/34.
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Sefa-Dapaah, Daniel. "An investigation into the relationship between John the Baptist and Jesus of Nazareth : a socio-historical study." Thesis, Coventry University, 1995. http://curve.coventry.ac.uk/open/items/c882b9b9-f1d9-e999-ebf8-c97928f7a66f/1.
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The aim of this thesis is to examine and critically evaluate the relationship between John the Baptist and Jesus of Nazareth, with special reference to baptism and to the question of whether Jesus practised a baptising ministry in Galilee. This involves us taking a fresh look at the Gospel texts on John and Jesus and considering the possible relevance of the Dead Sea Scrolls. Part I provides a preliminary examination of our sources. Part II focuses on possible links between John, the Essenes and the early Church. We argue: (i) that after his birth into a priestly family, John was probably brought up by the Essenes at Qumran, whom he later left to conduct an independent prophetic and baptising ministry by the Jordan; (ii) that the Qumran immersions provide the matrix to John's baptismal rite; (iii) that the affinity between the Essenes and the early Church in ideology and praxis may be owing to the influence of the former upon the latter, with John as the mediator between the two. Against this background, John and Jesus are directly related to each other in Part III. We conclude: (i) that after his baptism by John, Jesus remained a follower of John for a time, and practised a baptising ministry concurrent with that of John in Judea (John 3.22-26; 4.1-2); (ii) that Jesus continued this ministry in Galilee; (iii) that the synoptists' silence about Jesus' baptising (e.g. Mk 6.7-13 and par; Matt 10.5-16; Q=Matt 9.37-38//Lk 10.1-12) may indicate that they took it for granted, or that they were embarrassed by it; (iv) that unlike fasting, sabbath observance, tithes and offerings, purity, etc, baptism was not among the contentious issues relating to Jewish law; (v) that the emphasis on baptism in the post-Easter context of the Church was necessitated by its redefinition in the name of Jesus (Acts 2.38; 19.1-7; Rom 6.3; Gal 3.27; cf. the Trinitarian formula in Matt 28.19 [cf. Mk 16.15-16]); and (vi) that perhaps the strongest argument for John as mediator between the Essenes, Jesus and the early Church is precisely the ambivalence of the New Testament writers' attitude toward him.
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Herbst, Walter Brown. "Can current design and development management pedagogy respond better in reflecting industry needs?" Thesis, Coventry University, 2017. http://curve.coventry.ac.uk/open/items/a7d302d5-ebfc-40ee-9d95-f2e06ef4ebb2/1.
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The purpose of this study is to bring clarity and consistency to the academic field that concentrates on management of product design and development. The research explores the assumption that no common standards exist for the education of those wishing to assume a managerial position in that field. The findings have shown a significant lack of consistency in both the subjects offered as well as the naming of the subject in terms of the public presentation. As such, those who wish to enter the field, as well as those wishing to hire leadership, are met with dramatically varied educational background and degree titles. This study presents a review of all identified existing graduate programmes —of which there are 35 institutions worldwide, teaching 60 different courses, with 24 separate degree names. This research explores and identifies the most relevant courses in response to leaders in industry. In his work, Schön (1983) references relevancy in terms of competence that is valued in professional practise as opposed to knowledge taught in academia, and this thesis explores what is practiced and what should be taught. Three distinct groups within the USA were interviewed, including the following: 1) eleven educators responsible for these programme , 2) twenty design-centric industry leaders who hire managers for professional practice, and 3) ninety alumni who have graduated from one particular programme. The tacit knowledge of key leaders needs and the general references made to relevance over rigour are the impetus for the study. Valuing and addressing industry needs and ultimately recommending a course of action that aligns academic training with a more industry relevant content has been the overriding direction for this work. It is that debate that this research, for the first time, addresses the wants of industry, through clarifying eight specific courses to satisfy the need for trained graduate students in the role of management of product design and development within the context of the USA.
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Fair, Jenna Leigh. "Spatially fractionated proton therapy: A Monte Carlo verification." Thesis, Georgia Institute of Technology, 2016. http://hdl.handle.net/1853/55045.
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Spatially fractionated radiation therapy (or grid) using megavoltage x-rays is a relatively new method of treating bulky (>8 cm) malignant tumors. Unlike the conventional approach in which the entire tumor is targeted with a nearly uniform radiation field, in grid the incident radiation is collimated with a special grid collimator. As such, only the volume under the open areas of the grid receives direct irradiation from the incident beam; the rest only sees scattered radiation and hence receives significantly less dose. Those regions seeing less dose serve as regrowth areas for normal tissues, thus reducing the normal tissue complication probability after the treatment. Although the grid dose distribution in a tumor is non-uniform, the regression of tumor mass has exhibited uniform regression clinically. Protons have two advantages over megavoltage x-rays which are typically used for grid: (1) protons scatter less in tissue, and (2) they have a fixed range in tissue (the Bragg peak) that can be used to target a tumor. The goal of this thesis is to computationally and experimentally assess the feasibility of grid using clinical proton beams. The proton pencil beams at the Provision Cancer Center in Knoxville, Tennessee, are used to create an array of beams mimicking the arrangement of beams in grid therapy. The dose distributions at various depths in a solid-water phantom are obtained computationally by the Monte Carlo code MCNP and validated by RayStation experimental Gafchromic film EBT3. The results are compared with those of the grid using megavoltage x-rays.
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Masserdotti, Giacomo. "ZFP423 coordinates Notch Pathway, Bmp Signaling and EBF/COE transcription factors to regulate Hes5 Gene Expression." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527455.
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Romanow, William Joseph Jr. "The roles of E2A and EBF in the regulation of the recombination of the immunoglobulin loci /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2000. http://wwwlib.umi.com/cr/ucsd/fullcit?p9963660.
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Narasimhan, Srivatsan. "Reliable, Efficient and Distributed Cooperative Caching for Improving File System Performance." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin985880302.
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Bohle, Verena [Verfasser], Ralf [Akademischer Betreuer] Küppers, and Shirley [Akademischer Betreuer] Knauer. "Bedeutung von B-Zell-spezifischen Transkriptionsfaktoren, insbesondere EBF1, für die Tumorzellen des Hodgkin-Lymphoms / Verena Bohle. Gutachter: Shirley Knauer. Betreuer: Ralf Küppers." Duisburg, 2012. http://d-nb.info/1022790994/34.
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Larousserie, Frédérique. "Analyse de l'expression d'une nouvelle cytokine, l'interleukine-27, dans les lymphocytes normaux et tumoraux et de son rôle au cours de la différenciation lymphocytaire B normale." Phd thesis, Université René Descartes - Paris V, 2005. http://tel.archives-ouvertes.fr/tel-00101553.
Full textAbstract:
L'interleukine (IL)-27, constituée de EBV-induced gene 3 (EBI3) et de p28, joue un rôle important dans la régulation des réponses T. Son rôle dans la réponse B est peu connu. EBI3 est une protéine induite in vitro par l'oncogène viral LMP1 via l'activation de NF-kB. Ce travail montre qu'EBI3 est également induite par l'oncogène Tax du virus HTLV-1, de façon dépendante de NF-kB, et est exprimée in situ par les cellules tumorales dans les lymphomes EBV+ LMP1+ et dans certains lymphomes associés à l'HTLV-1, en l'absence de détection de p28. Nous montrons que l'IL-27 a des effets directs sur le lymphocyte B humain, modulés au cours de la différenciation et dépendants du type de co-stimulation. EBI3, mais pas p28, est exprimée par des cellules B du centre germinatif (CG) et par les cellules tumorales de lymphomes B d'origine du CG. Ces résultats suggèrent un rôle d'EBI3 indépendamment de son association à p28.
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Garel, Sonia. "Clonage, expression et fonction d'une famille multigenique apparentee a ebf/olf-1 dans le systeme nerveux central embryonnaire." Paris 6, 1999. http://www.theses.fr/1999PA066204.
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Le but de mon travail a ete de determiner le role de genes apparentes a ebf/olf-1/collier, qui code pour un facteur de transcription helix-loop-helix, dans la formation du systeme nerveux central (snc) embryonnaire de la souris. Nous avons tout d'abord isole deux nouveaux genes apparentes a ebf/olf-1, nommes ebf2 et ebf3. Les trois genes ebf presentent de fortes similitudes de sequences indiquant qu'ils forment une nouvelle famille multigenique. L'etude comparative du profil d'expression de ebf (rebaptise ebf1), ebf2 et ebf3 suggere que cette nouvelle famille pourrait participer au controle de la differenciation de sous-populations neuronales. Dans le but de caracteriser le role de l'un des membres de cette famille, nous avons analyse le developpement embryonnaire chez des souris ebf1 - / -. Il avait ete montre que l'inactivation de ebf1 n'affecte pas de maniere dramatique la formation du snc, suggerant que ebf2 et ebf3 pourraient compenser la perte de fonction de ebf1. L'analyse comparative du profil d'expression des trois genes nous a permis d'identifier deux structures dans lesquelles ebf1 est le seul membre de la famille exprime : le striatum et le noyau moteur facial. Nous avons montre que l'inactivation de ebf1 affecte la differenciation des cellules striatales au moment ou elles migrent des zones proliferatives vers le manteau. Chez les nouveaux-nes ebf1 - / -, le striatum est fortement reduit et des faisceaux de fibres qui traversent le striatum presentent des defauts de navigation axonale. L'inactivation de ebf1 affecte donc une etape precise de differenciation des cellules striatales et perturbe severement la formation du striatum mature. De plus, nous avons montre que la migration des motoneurones faciaux est affectee dans les embryons ebf1 - / -. Ces analyses montrent que ebf1 joue un role majeur dans la differenciation neuronale dans deux structures du cerveau et suggerent un role plus general pour la famille ebf dans la differenciation neuronale.
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Milhau, Jérémy. "Un processus formel d'intégration de politiques de contrôle d'accès dans les systèmes d'information." Phd thesis, Université Paris-Est, 2011. http://tel.archives-ouvertes.fr/tel-00674865.
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La sécurité est un élément crucial dans le développement d'un système d'information. On ne peut pas concevoir un système bancaire sans préoccupation sécuritaire. La sensibilité des données d'un système hospitalier nécessite que la sécurité soit la composante majeure d'un tel logiciel. Le contrôle d'accès est un des nombreux aspects de la sécurité. Il permet de définir les conditions de l'exécution d'actions dans un système par un utilisateur. Entre les différentes phases de conception d'une politique de contrôle d'accès et son application effective sur un système déployé, de nombreuses étapes peuvent introduire des erreurs ou des failles non souhaitables. L'utilisation de méthodes formelles est une réponse à ces préoccupations dans le cadre de la modélisation de politiques de contrôle d'accès. L'algèbre de processus EB3 permet une modélisation formelle de systèmes d'information. Son extension EB3SEC a été conçue pour la spécification de politiques de contrôle d'accès. Le langage ASTD, combinaison des statecharts de Harel et des opérateurs de EB3, permet de modéliser graphiquement et formellement un système d'information. Cependant, ces deux méthodes manquent d'outils de vérification et de validation qui permettent de prouver ou de vérifier des propriétés de sécurité indispensables à la validation de politiques de contrôle d'accès. De plus, il est important de pouvoir prouver que l'implémentation d'une politique correspond bien à sa spécification abstraite. Cette thèse définit des règles de traduction de EB3 vers ASTD, d'ASTD vers event-B et vers B. Elle décrit également une architecture formelle exprimée en B d'un filtre de contrôle d'accès pour les systèmes d'information. Cette modélisation en B permet de prouver des propriétés à l'aide du prouveur B ou de vérifier des propriétés avec ProB, un vérificateur de modèles. Enfin, une stratégie de raffinement B pour obtenir une implémentation de ce filtre de contrôle d'accès est présentée. Les raffinements B étant prouvés, l'implémentation correspond donc au modèle initial de la politique de contrôle d'accès