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Journal articles on the topic 'ECM-model'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Sciumè, G., R. Santagiuliana, M. Ferrari, P. Decuzzi, and B. A. Schrefler. "A tumor growth model with deformable ECM." Physical Biology 11, no. 6 (2014): 065004. http://dx.doi.org/10.1088/1478-3975/11/6/065004.

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Raschke, S., L. Nehrenheim, M. Barth, A. Barbian, A. Lichtenberg, and P. Akhyari. "Novel Three-Dimensional Hydrogel Model from Ovine Aortic Valve ECM to Study ECM Remodeling." Thoracic and Cardiovascular Surgeon 65, S 01 (2017): S1—S110. http://dx.doi.org/10.1055/s-0037-1598740.

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3

He, Hongxing, Astrid Meyer, Per-Erik Jansson, Magnus Svensson, Tobias Rütting, and Leif Klemedtsson. "Simulating ectomycorrhiza in boreal forests: implementing ectomycorrhizal fungi model MYCOFON in CoupModel (v5)." Geoscientific Model Development 11, no. 2 (2018): 725–51. http://dx.doi.org/10.5194/gmd-11-725-2018.

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Abstract. The symbiosis between plants and Ectomycorrhizal fungi (ECM) is shown to considerably influence the carbon (C) and nitrogen (N) fluxes between the soil, rhizosphere, and plants in boreal forest ecosystems. However, ECM are either neglected or presented as an implicit, undynamic term in most ecosystem models, which can potentially reduce the predictive power of models.In order to investigate the necessity of an explicit consideration of ECM in ecosystem models, we implement the previously developed MYCOFON model into a detailed process-based, soil–plant–atmosphere model, Coup-MYCOFON,

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Kumar Mittal, Varinder, and Kuldip Singh Sangwan. "Development of a structural model of environmentally conscious manufacturing drivers." Journal of Manufacturing Technology Management 25, no. 8 (2014): 1195–208. http://dx.doi.org/10.1108/jmtm-02-2013-0012.

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Purpose – Manufacturing firms consume energy and natural resources in highly unsustainable manner and release huge amounts of green house gases leading to many economic, environmental and social problems; from local waste disposal to climate change. Consciousness about these issues has lead to a new manufacturing paradigm of environmentally conscious manufacturing (ECM). There exist many social, legislative, policy, economic, internal, and environmental factors which can motivate and/or force industry to adopt ECM. The purpose of this paper is to identify the drivers for ECM, developing a mode

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Huang, Xiaoqi, Honggui Han, and Junfei Qiao. "Energy consumption model for wastewater treatment process control." Water Science and Technology 67, no. 3 (2013): 667–74. http://dx.doi.org/10.2166/wst.2012.563.

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Wastewater treatment must satisfy discharge requirements under specified constraints and have minimal operating costs (OC). The operating results of wastewater treatment processes (WWTPs) have significantly focused on both the energy consumption (EC) and effluent quality (EQ). To reflect the relationship between the EC and EQ of WWTPs directly, an extended Elman neural network-based energy consumption model (EENN-ECM) was studied for WWTP control in this paper. The proposed EENN-ECM was capable of predicting EC values in the treatment process. Moreover, the self-adaptive characteristic of the

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Kim, Min-Cheol, Yaron R. Silberberg, Rohan Abeyaratne, Roger D. Kamm, and H. Harry Asada. "Computational modeling of three-dimensional ECM-rigidity sensing to guide directed cell migration." Proceedings of the National Academy of Sciences 115, no. 3 (2018): E390—E399. http://dx.doi.org/10.1073/pnas.1717230115.

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Filopodia have a key role in sensing both chemical and mechanical cues in surrounding extracellular matrix (ECM). However, quantitative understanding is still missing in the filopodial mechanosensing of local ECM stiffness, resulting from dynamic interactions between filopodia and the surrounding 3D ECM fibers. Here we present a method for characterizing the stiffness of ECM that is sensed by filopodia based on the theory of elasticity and discrete ECM fiber. We have applied this method to a filopodial mechanosensing model for predicting directed cell migration toward stiffer ECM. This model p

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Sun, Ruiqin, Guanzhong Yang, Dafang Zhang, and Bowen Yang. "ECM: An Formal Embedded Component Model for Embedded System." International Journal of Control and Automation 8, no. 6 (2015): 293–306. http://dx.doi.org/10.14257/ijca.2015.8.6.29.

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8

Rajurkar, K. P., B. Wei, and C. L. Schnacker. "Monitoring and Control of Electrochemical Machining (ECM)." Journal of Engineering for Industry 115, no. 2 (1993): 216–23. http://dx.doi.org/10.1115/1.2901652.

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The main advantages of the electrochemical machining (ECM) process, such as high material removal rates and smooth, damage-free machined surface, are often offset by the poor dimensional control and process stability resulting from the complex and stochastic nature of the interelectrode gap (IEG) states. Full economic utilization of ECM will be realized only when reliable dimensional and process control systems are developed. This paper presents an ECM control model based on the basic ECM dynamics that accounts for the dynamic nature of the ECM process. The state space methodology is applied t

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Liu, Wei, Jie Huang, Yong Shen, and Jiazheng Cheng. "Theoretical Modeling of Piezoelectric Cantilever MEMS Loudspeakers." Applied Sciences 11, no. 14 (2021): 6323. http://dx.doi.org/10.3390/app11146323.

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Piezoelectric microelectromechanical system (MEMS) loudspeakers have received extensive attention in recent years. In particular, the piezoelectric cantilever MEMS loudspeaker, which uses multilayer piezoelectric cantilever actuators (MPCAs), has attracted attention because of its small size, low cost, ease of manufacture, and desirable piston movement. However, owing to the complex driving principles of MPCAs, no adequately efficient and appropriate method currently exists that can be used to analyze and predict the performance of piezoelectric cantilever MEMS loudspeakers. In this study, the

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10

Lugo-Cintrón, Karina M., Max M. Gong, José M. Ayuso, et al. "Breast Fibroblasts and ECM Components Modulate Breast Cancer Cell Migration through the Secretion of MMPs in a 3D Microfluidic Co-Culture Model." Cancers 12, no. 5 (2020): 1173. http://dx.doi.org/10.3390/cancers12051173.

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The extracellular matrix (ECM) composition greatly influences cancer progression, leading to differential invasion, migration, and metastatic potential. In breast cancer, ECM components, such as fibroblasts and ECM proteins, have the potential to alter cancer cell migration. However, the lack of in vitro migration models that can vary ECM composition limits our knowledge of how specific ECM components contribute to cancer progression. Here, a microfluidic model was used to study the effect of 3D heterogeneous ECMs (i.e., fibroblasts and different ECM protein compositions) on the migration dist

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Wu, Rui, Dan Wen Zhang, and Juan Sun. "Shaping Law and Motion Design in NC-ECM under Effect of Twiste Angle." Applied Mechanics and Materials 128-129 (October 2011): 1010–14. http://dx.doi.org/10.4028/www.scientific.net/amm.128-129.1010.

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The twiste angle has a great effect on shaping law and stability of Numerical Controlled Electrochemical Machining (NC-ECM) process. In order to avoid the disadvantages caused by twiste angle, a methode of study shaping law by dispersing cathode working face in NC-ECM was proposed, and a mathematical model of the shaping law with the effects of twiste angle has been established in this paper. The mathematical model disclosed the relationship of twiste angle β, feeding velocity vf and thickness of removal material h in NC-ECM. Theoretical and experimental results show the the mathematical model

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Ariyasinghe, Nethika R., Davi M. Lyra-Leite, and Megan L. McCain. "Engineering cardiac microphysiological systems to model pathological extracellular matrix remodeling." American Journal of Physiology-Heart and Circulatory Physiology 315, no. 4 (2018): H771—H789. http://dx.doi.org/10.1152/ajpheart.00110.2018.

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Many cardiovascular diseases are associated with pathological remodeling of the extracellular matrix (ECM) in the myocardium. ECM remodeling is a complex, multifactorial process that often contributes to declines in myocardial function and progression toward heart failure. However, the direct effects of the many forms of ECM remodeling on myocardial cell and tissue function remain elusive, in part because conventional model systems used to investigate these relationships lack robust experimental control over the ECM. To address these shortcomings, microphysiological systems are now being devel

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Katuu, Shadrack. "Assessing the functionality of the enterprise content management maturity model." Records Management Journal 26, no. 2 (2016): 218–38. http://dx.doi.org/10.1108/rmj-08-2015-0030.

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Purpose The implementation of enterprise content management (ECM) software applications has been a subject of extensive discussion. Although a number of ECM scholars have provided guidance on ECM implementation, there is a gap in how to assess benefits accruing from the implementation. One of the approaches of assessment is the use of maturity models. This paper aims to examine the utility of other ECM maturity model (ECM3) as an assessment tool. Design/methodology/approach The study was undertaken based on two related research questions, the first explored ECM3 assessment within a South Afric

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Kumar Mittal, Varinder, and Kuldip Singh Sangwan. "Modeling drivers for successful adoption of environmentally conscious manufacturing." Journal of Modelling in Management 9, no. 2 (2014): 127–40. http://dx.doi.org/10.1108/jm2-03-2013-0011.

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Purpose – This paper aims at developing an interpretive structural model of drivers for environmentally conscious manufacturing (ECM). It will demonstrate how interpretive structural modeling (ISM) supports policy makers in the government and industry in identifying and understanding interdependencies among drivers for ECM. Interdependencies among drivers will be derived and structured into a hierarchy to derive subsystems of interdependent elements with corresponding driving power and dependency. Design/methodology/approach – ISM has been used to identify hierarchy and inter-relationships amo

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Sun, Mingliang, Yunfan He, Tao Zhou, Pan Zhang, Jianhua Gao, and Feng Lu. "Adipose Extracellular Matrix/Stromal Vascular Fraction Gel Secretes Angiogenic Factors and Enhances Skin Wound Healing in a Murine Model." BioMed Research International 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/3105780.

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Mesenchymal stem cells are an attractive cell type for cytotherapy in wound healing. The authors recently developed a novel, adipose-tissue-derived, injectable extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) for stem cell therapy. This study was designed to assess the therapeutic effects of ECM/SVF-gel on wound healing and potential mechanisms. ECM/SVF-gel was prepared for use in nude mouse excisional wound healing model. An SVF cell suspension and phosphate-buffered saline injection served as the control. The expression levels of vascular endothelial growth factor (VEGF), bas

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16

Akimoto, Benjamin, and Wataru Natsu. "Study on Parameter Determination for ECM Equivalent Circuit." Applied Mechanics and Materials 220-223 (November 2012): 1990–94. http://dx.doi.org/10.4028/www.scientific.net/amm.220-223.1990.

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The analysis of the ECM model expressed by an equivalent circuit is helpful to understand the ECM characteristics, such as the removal rate and machining accuracy. However, the parameters in the ECM equivalent circuit have not been determined yet, although several kinds of equivalent circuits were proposed. In this research, the parameters of the ECM equivalent circuit were determined experimentally, and the determination reliability was discussed.

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Anwar, A. I., Kurniaty, N. R. S. Wulandari, and R. Fitrianti. "Application of Error Correction Model (ECM) in stabilizing financial inclusion." IOP Conference Series: Earth and Environmental Science 473 (May 14, 2020): 012117. http://dx.doi.org/10.1088/1755-1315/473/1/012117.

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Liu, Binghui, Ling Leng, Xuer Sun, Yunfang Wang, Jie Ma, and Yunping Zhu. "ECMPride: prediction of human extracellular matrix proteins based on the ideal dataset using hybrid features with domain evidence." PeerJ 8 (April 29, 2020): e9066. http://dx.doi.org/10.7717/peerj.9066.

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Extracellular matrix (ECM) proteins play an essential role in various biological processes in multicellular organisms, and their abnormal regulation can lead to many diseases. For large-scale ECM protein identification, especially through proteomic-based techniques, a theoretical reference database of ECM proteins is required. In this study, based on the experimentally verified ECM datasets and by the integration of protein domain features and a machine learning model, we developed ECMPride, a flexible and scalable tool for predicting ECM proteins. ECMPride achieved excellent performance in pr

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Zhang, Hong, Yaobin Lu, Sumeet Gupta, and Ping Gao. "Understanding group-buying websites continuance." Internet Research 25, no. 5 (2015): 767–93. http://dx.doi.org/10.1108/intr-05-2014-0127.

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Purpose – Sustainable success of group-buying web sites implies that consumers not only accept them initially but also use them continuously. Most group-buying web sites, however, are unable to achieve such sustainable success. Drawing on expectation-confirmation model (ECM), the purpose of this paper is to examine the factors that influence group-buying web sites continuance. Design/methodology/approach – In total, 605 valid responses were collected via a survey of a leading group-buying web site in China. Structural equation modeling was used to test the research model. This study also compa

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Martinez-Garcia, Francisco Drusso, Roderick Harold Jan de Hilster, Prashant Kumar Sharma, et al. "Architecture and Composition Dictate Viscoelastic Properties of Organ-Derived Extracellular Matrix Hydrogels." Polymers 13, no. 18 (2021): 3113. http://dx.doi.org/10.3390/polym13183113.

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The proteins and polysaccharides of the extracellular matrix (ECM) provide architectural support as well as biochemical and biophysical instruction to cells. Decellularized, ECM hydrogels replicate in vivo functions. The ECM’s elasticity and water retention renders it viscoelastic. In this study, we compared the viscoelastic properties of ECM hydrogels derived from the skin, lung and (cardiac) left ventricle and mathematically modelled these data with a generalized Maxwell model. ECM hydrogels from the skin, lung and cardiac left ventricle (LV) were subjected to a stress relaxation test under

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Santos, Angelo Gabrielle. "Forecasting residential electricity demand in the Philippines using an error correction model." Philippine Review of Economics 57, no. 1 (2021): 121–51. http://dx.doi.org/10.37907/6erp0202j.

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This study uses an Error Correction Model (ECM) to forecast residential electricity demand in the Philippines using household final consumption expenditure, residential electricity price, and temperature as explanatory variables. Results show that there is a long-run relationship between household final consumption expenditure and residential electricity demand. Estimates from the ECM are consistent with economic theory, and the model passed standard diagnostic and parameter stability tests. Forecast performance based on within-sample and out-of-sample forecasts of the ECM is also shown to be

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Ge, Yuan Yuan, Fu Yuan Wang, Ai Mei Zhang, and Su Tao Zhuang. "Analysis and Research of Mathematical-Physical Models on Simulation of Electrochemical Machining." Advanced Materials Research 314-316 (August 2011): 473–76. http://dx.doi.org/10.4028/www.scientific.net/amr.314-316.473.

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In this paper, in order to make the simulation of the whole process of electrochemical machining(ECM), the characteristic of electric field and flow field is made detailed analysis in the gap of ECM. Mathematical-physical models of ECM simulation is set up based on the basic theories of electrochemistry, electric field and flow field. And the method of model solution is discussed and researched. So the theoretical base is established of the full process of ECM simulation.

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Gao, Yingxin, Alan S. Wineman, and Anthony M. Waas. "Time-dependent lateral transmission of force in skeletal muscle." Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences 465, no. 2108 (2009): 2441–60. http://dx.doi.org/10.1098/rspa.2009.0059.

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There is experimental evidence to suggest that extensible connective tissues are mechanically time-dependent. In view of this, the mechanics of time-dependent lateral stress transfer in skeletal muscle is investigated by employing a viscoelastic shear lag model for the transfer of tensile stress between muscle fibres and the surrounding extracellular matrix (ECM) by means of shear stresses at the interface between the muscle fibre and the ECM. The model allows for both mechanical strains in the muscle as well as the strain owing to muscle contraction. Both the ECM and the muscle fibre are mode

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Bogunovic, Natalija, Jorn P. Meekel, Jisca Majolée, et al. "Patient-Specific 3-Dimensional Model of Smooth Muscle Cell and Extracellular Matrix Dysfunction for the Study of Aortic Aneurysms." Journal of Endovascular Therapy 28, no. 4 (2021): 604–13. http://dx.doi.org/10.1177/15266028211009272.

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Introduction: Abdominal aortic aneurysms (AAAs) are associated with overall high mortality in case of rupture. Since the pathophysiology is unclear, no adequate pharmacological therapy exists. Smooth muscle cells (SMCs) dysfunction and extracellular matrix (ECM) degradation have been proposed as underlying causes. We investigated SMC spatial organization and SMC-ECM interactions in our novel 3-dimensional (3D) vascular model. We validated our model for future use by comparing it to existing 2-dimensional (2D) cell culture. Our model can be used for translational studies of SMC and their role i

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Horne, Stephanie Burnett, and Suliman Hawamdeh. "Factors Impacting the Implementation of Enterprise Content Management Systems." Journal of Information & Knowledge Management 14, no. 01 (2015): 1550008. http://dx.doi.org/10.1142/s0219649215500082.

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Enterprise content management (ECM) is a new and fast growing area. It is still undergoing the same defining process as predecessor systems such as decision support and enterprise resource systems. A qualitative case study was conducted to identify key factors that impact the success of ECM systems implementations. A theoretical framework was developed from the information systems (ISs) literature resulting in a research model defining five categories of factors that impact ECM implementation success with these questions: Are there managerial, user, task, technological and content related fact

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Anil Kumar, K., and Subhashree Natarajan. "An extension of the Expectation Confirmation Model (ECM) to study continuance behavior in using e-Health services." Innovative Marketing 16, no. 2 (2020): 15–28. http://dx.doi.org/10.21511/im.16(2).2020.02.

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Given the negative utilitarianism and difficulty in maintaining long-term loyalty, hospitals resort to a variety of images that define and redefine their relationship strategies in order to stay patient-centric. As in any other sector, in healthcare, patients play an important role in service design and delivery. The basic services of medical appointment scheduling, online payment and health information search are recognized as one of the most important elements that increase patient footfall, service planning, patient satisfaction and their continued usage, in particular in developing economi

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Saragih, Ansheila Yunian, and Lavlimattria Esya. "PENGARUH KINERJA MAKROEKONOMI TERHADAP DANA PIHAK KETIGA BANK SYARIAH INDONESIA." Media Ekonomi 24, no. 2 (2016): 151. http://dx.doi.org/10.25105/me.v24i2.3801.

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<p><em>This study Aimed to analyze the influence of GDP, SBIS and inflation on third-party funds (DPK), in the short term and long term in the period quarterely 2008: 1 until 2014: 4. The variables used are third party funds (DPK), Gross Domestic Product (GDP), inflation, and Bank Indonesia Certificates Sharia (SBIS). Mmethodology used is a method of Error Correction Model (ECM). Before the test of Error Correction Model (ECM), the models must pass the prerequisite test unit root, integration and Co integration. The results showed the models Prerequisites Error Correction Model (EC

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Tran, Quyen A., Visar Ajeti, Brian T. Freeman, Paul J. Campagnola, and Brenda M. Ogle. "Developmental Pathways Pervade Stem Cell Responses to Evolving Extracellular Matrices of 3D Bioprinted Microenvironments." Stem Cells International 2018 (2018): 1–15. http://dx.doi.org/10.1155/2018/4809673.

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Developmental studies and 3D in vitro model systems show that the production and engagement of extracellular matrix (ECM) often precede stem cell differentiation. Yet, unclear is how the ECM triggers signaling events in sequence to accommodate multistep process characteristic of differentiation. Here, we employ transcriptome profiling and advanced imaging to delineate the specificity of ECM engagement to particular differentiation pathways and to determine whether specificity in this context is a function of long-term ECM remodeling. To this end, human mesenchymal stem cells (hMSCs) were cultu

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Zhu, Jie, and Alex Mogilner. "Comparison of cell migration mechanical strategies in three-dimensional matrices: a computational study." Interface Focus 6, no. 5 (2016): 20160040. http://dx.doi.org/10.1098/rsfs.2016.0040.

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Cell migration on a two-dimensional flat surface has been extensively studied and is generally characterized by a front-protrusion–rear-contraction process. In a three-dimensional (3D) environment, on the other hand, cells adopt multiple migration strategies depending on the cell type and the properties of the extracellular matrix (ECM). By using computer simulations, we find that these migration strategies can be classified by various spatial–temporal dynamics of actin protrusion, actin–myosin contraction and actin–ECM adhesion. We demonstrate that if we include or exclude proteolysis of ECM,

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Wei, Xu, Ying Li, Xiaodan Sun, et al. "Erythropoietin Protects against Murine Cerebral Malaria through Actions on Host Cellular Immunity." Infection and Immunity 82, no. 1 (2013): 165–73. http://dx.doi.org/10.1128/iai.00929-13.

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ABSTRACTCerebral malaria (CM) is associated with excessive host proinflammatory responses and endothelial activation. The hematopoietic hormone erythropoietin (EPO) possesses neuroprotective functions in animal models of ischemic-hypoxic, traumatic, and inflammatory injuries. In thePlasmodium bergheiANKA model of experimental CM (ECM), recombinant human EPO (rhEPO) has shown evident protection against ECM. To elucidate the mechanism of EPO in this ECM model, we investigated the effect of rhEPO on host cellular immune responses. We demonstrated that improved survival of mice with ECM after rhEP

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McCarthy, J., and E. A. Turley. "Effects of Extracellular Matrix Components on Cell Locomotion." Critical Reviews in Oral Biology & Medicine 4, no. 5 (1993): 619–37. http://dx.doi.org/10.1177/10454411930040050101.

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The extracellular matrix (ecm), which is composed of collagens, glycoproteins, and proteoglycans, has emerged as an important regulator of cell locomotion. This review describes some of the mechanisms by which the ecm may regulate locomotion, focusing primarily on cell extension and lamellae formation. Ecm-receptor interactions form an important part of cell recognition of ecm. Such interactions can result in altered cell adhesion, signal transduction, and cytoskeletal organization, all of which impact on cell locomotion. It is important to note that although the effects of single ecm componen

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Bidan, Cécile M., Philip Kollmannsberger, Vanessa Gering, et al. "Gradual conversion of cellular stress patterns into pre-stressed matrix architecture during in vitro tissue growth." Journal of The Royal Society Interface 13, no. 118 (2016): 20160136. http://dx.doi.org/10.1098/rsif.2016.0136.

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The complex arrangement of the extracellular matrix (ECM) produced by cells during tissue growth, healing and remodelling is fundamental to tissue function. In connective tissues, it is still unclear how both cells and the ECM become and remain organized over length scales much larger than the distance between neighbouring cells. While cytoskeletal forces are essential for assembly and organization of the early ECM, how these processes lead to a highly organized ECM in tissues such as osteoid is not clear. To clarify the role of cellular tension for the development of these ordered fibril arch

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Mansour, Dina, and Hortensia Barandas. "High-tech entrepreneurial content marketing for business model innovation." Journal of Research in Interactive Marketing 11, no. 3 (2017): 296–311. http://dx.doi.org/10.1108/jrim-03-2016-0022.

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Purpose The purpose of this paper is to advance the theoretical development of the content marketing concept and its integration into high-tech marketing theory, in entrepreneurial contexts and from a business model innovation perspective. Design/methodology/approach The paper provides a conceptual overview of content marketing and business model innovation concerning high-tech entrepreneurs. Findings The high-tech entrepreneurial content marketing (HIT-ECM) framework has five delineating elements with a small high-tech firm as the focal point: adapting content marketing in the business model,

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Fang, Liu, Liu Xinyi, Su Weixing, Chen Hanning, He Maowei, and Liang Xiaodan. "State-of-Health Online Estimation for Li-Ion Battery." SAE International Journal of Electrified Vehicles 9, no. 2 (2020): 185–96. http://dx.doi.org/10.4271/14-09-02-0012.

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To realize a fast and high-precision online state-of-health (SOH) estimation of lithium-ion (Li-Ion) battery, this article proposes a novel SOH estimation method. This method consists of a new SOH model and parameters identification method based on an improved genetic algorithm (Improved-GA). The new SOH model combines the equivalent circuit model (ECM) and the data-driven model. The advantages lie in keeping the physical meaning of the ECM while improving its dynamic characteristics and accuracy. The improved-GA can effectively avoid falling into a local optimal problem and improve the conver

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Wang, Linhao, Fang Wang, Liling Zhao, et al. "Mesenchymal Stem Cells Coated by the Extracellular Matrix Promote Wound Healing in Diabetic Rats." Stem Cells International 2019 (January 28, 2019): 1–7. http://dx.doi.org/10.1155/2019/9564869.

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Objective. To investigate the effects of mesenchymal stem cells (MSCs) coated by the extracellular matrix (ECM) on wound healing in diabetic rats. Methods. Mesenchymal stem cells were cocultured with ECM. Cell viabilities were evaluated using MTT assay. The diabetes model was established using both STZ and high-glucose/fat methods in SD rats. A wound area was made on the middle of the rats’ back. MSCs or ECM-MSCs were used to treat the rats. HE staining and CD31 immunohistochemistry were used to detect the skin thickness and angiogenesis. Western blotting and qRT-PCR were conducted to determin

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DING, YAN, WENYUE XU, TAOLI ZHOU, TAIPING LIU, HONG ZHENG, and YONG FU. "Establishment of a murine model of cerebral malaria in KunMing mice infected with Plasmodium berghei ANKA." Parasitology 143, no. 12 (2016): 1672–80. http://dx.doi.org/10.1017/s0031182016001475.

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SUMMARYMalaria remains one of the most devastating diseases. Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection resulting in high mortality and morbidity worldwide. Analysis of precise mechanisms of CM in humans is difficult for ethical reasons and animal models of CM have been employed to study malaria pathogenesis. Here, we describe a new experimental cerebral malaria (ECM) model with Plasmodium berghei ANKA infection in KunMing (KM) mice. KM mice developed ECM after blood-stage or sporozoites infection, and the development of ECM in KM mice has a dose-dependen

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Badylak, Stephen F., David A. Vorp, Alan R. Spievack, et al. "Esophageal Reconstruction with ECM and Muscle Tissue in a Dog Model." Journal of Surgical Research 128, no. 1 (2005): 87–97. http://dx.doi.org/10.1016/j.jss.2005.03.002.

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Cao, Xuan, Ehsan Ban, Brendon M. Baker, et al. "Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices." Proceedings of the National Academy of Sciences 114, no. 23 (2017): E4549—E4555. http://dx.doi.org/10.1073/pnas.1620486114.

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We describe a multiscale model that incorporates force-dependent mechanical plasticity induced by interfiber cross-link breakage and stiffness-dependent cellular contractility to predict focal adhesion (FA) growth and mechanosensing in fibrous extracellular matrices (ECMs). The model predicts that FA size depends on both the stiffness of ECM and the density of ligands available to form adhesions. Although these two quantities are independent in commonly used hydrogels, contractile cells break cross-links in soft fibrous matrices leading to recruitment of fibers, which increases the ligand dens

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Maddineni, Prabhavathi, Ramesh B. Kasetti, Bindu Kodati, Sam Yacoub, and Gulab S. Zode. "Sodium 4-Phenylbutyrate Reduces Ocular Hypertension by Degrading Extracellular Matrix Deposition via Activation of MMP9." International Journal of Molecular Sciences 22, no. 18 (2021): 10095. http://dx.doi.org/10.3390/ijms221810095.

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Ocular hypertension (OHT) is a serious adverse effect of the widely prescribed glucocorticoid (GC) therapy and, if left undiagnosed, it can lead to glaucoma and complete blindness. Previously, we have shown that the small chemical chaperone, sodium-4-phenylbutyrate (PBA), rescues GC-induced OHT by reducing ocular endoplasmic reticulum (ER) stress. However, the exact mechanism of how PBA rescues GC-induced OHT is not completely understood. The trabecular meshwork (TM) is a filter-like specialized contractile tissue consisting of TM cells embedded within extracellular matrix (ECM) that controls

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Gildner, Candace D., Amy L. Lerner, and Denise C. Hocking. "Fibronectin matrix polymerization increases tensile strength of model tissue." American Journal of Physiology-Heart and Circulatory Physiology 287, no. 1 (2004): H46—H53. http://dx.doi.org/10.1152/ajpheart.00859.2003.

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The composition and organization of the extracellular matrix (ECM) contribute to the mechanical properties of tissues. The polymerization of fibronectin into the ECM increases actin organization and regulates the composition of the ECM. In this study, we examined the ability of cell-dependent fibronectin matrix polymerization to affect the tensile properties of an established tissue model. Our data indicate that fibronectin polymerization increases the ultimate strength and toughness, but not the stiffness, of collagen biogels. A fragment of fibronectin that stimulates mechanical tension gener

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Nan, Hanqing, Yu Zheng, Yiheng H. Lin, et al. "Absorbing–active transition in a multi-cellular system regulated by a dynamic force network." Soft Matter 15, no. 35 (2019): 6938–45. http://dx.doi.org/10.1039/c9sm01244c.

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Migrating cells in 3D ECM can generate a dynamically evolving force network in the system. The role of active force network in regulating collective cell behaviors in 3D ECM is investigated using a minimal active-particle-on-network model.

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Wen, An, Jinhao Meng, Jichang Peng, Lei Cai, and Qian Xiao. "Online Parameter Identification of the Lithium-Ion Battery with Refined Instrumental Variable Estimation." Complexity 2020 (September 30, 2020): 1–12. http://dx.doi.org/10.1155/2020/8854618.

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Refined Instrumental Variable (RIV) estimation is applied to online identify the parameters of the Equivalent Circuit Model (ECM) for Lithium-ion (Li-ion) battery in this paper, which enables accurate parameters estimation with the measurement noise. Since the traditional Recursive Least Squares (RLS) estimation is extremely sensitive to the noise, the parameters in the ECM may fail to converge to their true values under the measurement noise. The RIV estimation is implemented in a bootstrap form, which alternates between the estimation in the system model and the noise model. The Box-Jenkins

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Haskett, Darren G., David Maestas, Stephen J. Howerton, et al. "2-Photon Characterization of Optical Proteolytic Beacons for Imaging Changes in Matrix-Metalloprotease Activity in a Mouse Model of Aneurysm." Microscopy and Microanalysis 22, no. 2 (2016): 349–60. http://dx.doi.org/10.1017/s1431927616000088.

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AbstractAbdominal aortic aneurysm is a multifactorial disease that is a leading cause of death in developed countries. Matrix-metalloproteases (MMPs) are part of the disease process, however, assessing their role in disease initiation and progression has been difficult and animal models have become essential. Combining Förster resonance energy transfer (FRET) proteolytic beacons activated in the presence of MMPs with 2-photon microscopy allows for a novel method of evaluating MMP activity within the extracellular matrix (ECM). Single and 2-photon spectra for proteolytic beacons were determined

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Kozak, Jerzy. "Quasi-Homogenous Model of Electrochemical Machining of Turbine Engine Parts." Journal of KONES 26, no. 3 (2019): 91–104. http://dx.doi.org/10.2478/kones-2019-0062.

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Abstract In order to increase the efficiency of jet engines hard to machine nickel-based and titanium-based alloys are in common use for aero engine components such as blades and blade integrated disks (BLISK). Electrochemical Machining (ECM) provides an economical and effective method for machining high strength and heat-resistant materials into complex shapes with high material removal rate without tool wear and without inducing residual stress. This article presents the physical and mathematical models of electrochemical shaping used in the manufacture of turbine engine parts. The modelling

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Du, Hui-Cong, Lin Jiang, Wen-Xin Geng, et al. "Growth Factor-Reinforced ECM Fabricated from Chemically Hypoxic MSC Sheet with Improved In Vivo Wound Repair Activity." BioMed Research International 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/2578017.

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MSC treatment can promote cutaneous wound repair through multiple mechanisms, and paracrine mediators secreted by MSC are responsible for most of its therapeutic benefits. Recently, MSC sheet composed of live MSCs and their secreted ECMs was reported to promote wound healing; however, whether its ECM alone could accelerate wound closure remained unknown. In this study, Nc-ECM and Cc-ECM were prepared from nonconditioned and CoCl2-conditioned MSC sheets, respectively, and their wound healing properties were evaluated in a mouse model of full-thickness skin defect. Our results showed that Nc-ECM

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Ramirez-San Juan, G. R., P. W. Oakes, and M. L. Gardel. "Contact guidance requires spatial control of leading-edge protrusion." Molecular Biology of the Cell 28, no. 8 (2017): 1043–53. http://dx.doi.org/10.1091/mbc.e16-11-0769.

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In vivo, geometric cues from the extracellular matrix (ECM) are critical for the regulation of cell shape, adhesion, and migration. During contact guidance, the fibrillar architecture of the ECM promotes an elongated cell shape and migration along the fibrils. The subcellular mechanisms by which cells sense ECM geometry and translate it into changes in shape and migration direction are not understood. Here we pattern linear fibronectin features to mimic fibrillar ECM and elucidate the mechanisms of contact guidance. By systematically varying patterned line spacing, we show that a 2-μm spacing

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Klegová, Jaroslava, and Ivana Rábová. "Enterprise content management in the cloud." Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis 61, no. 7 (2013): 2295–301. http://dx.doi.org/10.11118/actaun201361072295.

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At present the attention of many organizations concentrates to the Enterprise Content Management system (ECM). Unstructured content grows exponentially, and Enterprise Content Management system helps to capture, store, manage, integrate and deliver all forms of content across the company. Today, decision makers have possibility to move ECM systems to the cloud and take advantages of cloud computing. Cloud solution can provide a crucial competitive advantage. For example, it can reduce fixed IT department cost and ensure faster ECM implementation.To achieve the maximum level of benefits from im

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Blanco-Romero, Esther, Daniel Garrido-Sanz, Rafael Rivilla, Miguel Redondo-Nieto, and Marta Martín. "In Silico Characterization and Phylogenetic Distribution of Extracellular Matrix Components in the Model Rhizobacteria Pseudomonas fluorescens F113 and Other Pseudomonads." Microorganisms 8, no. 11 (2020): 1740. http://dx.doi.org/10.3390/microorganisms8111740.

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Biofilms are complex structures that are crucial during host–bacteria interaction and colonization. Bacteria within biofilms are surrounded by an extracellular matrix (ECM) typically composed of proteins, polysaccharides, lipids, and DNA. Pseudomonads contain a variety of ECM components, some of which have been extensively characterized. However, neither the ECM composition of plant-associated pseudomonads nor their phylogenetic distribution within the genus has been so thoroughly studied. In this work, we use in silico methods to describe the ECM composition of Pseudomonas fluorescens F113, a

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Karimi, Danial, Hamidreza Behi, Mohsen Akbarzadeh, Joeri Van Mierlo, and Maitane Berecibar. "Holistic 1D Electro-Thermal Model Coupled to 3D Thermal Model for Hybrid Passive Cooling System Analysis in Electric Vehicles." Energies 14, no. 18 (2021): 5924. http://dx.doi.org/10.3390/en14185924.

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Thermal management is the most vital element of electric vehicles (EV) to control the maximum temperature of module/pack for safety reasons. This paper presents a novel passive thermal management system (TMS) composed of a heat sink (HS) and phase change materials (PCM) for lithium-ion capacitor (LiC) technology under the premise that the cell is cycled with a continuous 150 A fast charge/discharge current rate. The experiments are validated against numerical analysis through a computational fluid dynamics (CFD) model. For this purpose, a comprehensive electro-thermal model based on an equival

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Pigeot, Sébastien, Paul Emile Bourgine, Jaquiery Claude, et al. "Orthotopic Bone Formation by Streamlined Engineering and Devitalization of Human Hypertrophic Cartilage." International Journal of Molecular Sciences 21, no. 19 (2020): 7233. http://dx.doi.org/10.3390/ijms21197233.

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Most bones of the human body form and heal through endochondral ossification, whereby hypertrophic cartilage (HyC) is formed and subsequently remodeled into bone. We previously demonstrated that HyC can be engineered from human mesenchymal stromal cells (hMSC), and subsequently devitalized by apoptosis induction. The resulting extracellular matrix (ECM) tissue retained osteoinductive properties, leading to ectopic bone formation. In this study, we aimed at engineering and devitalizing upscaled quantities of HyC ECM within a perfusion bioreactor, followed by in vivo assessment in an orthotopic

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