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Dissertations / Theses on the topic 'ECM proteiny'

Author: Grafiati

Published: 28 June 2021

Last updated: 29 July 2025

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1

Dvořák, Pavel. "Biomedicínské aplikace polykaprolaktonových nanovlákenných membrán." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-444549.

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The diploma thesis deals with the treatment of polycaprolactone (PCL) nanofibers. PCL fibers were subjected to the deposition of plasma amine polymers in a low pressure pulsed radiofrequency capacitively coupled discharge using cyclopropylamine monomer (CPA). Collagen as an extracellular matrix (ECM) protein was immobilized and cell proliferation on the modified nanofiber surface was monitored. Untreated PCL fibers were also subjected to the deposition of an antibacterial copper layer, and the fibers were characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XP

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2

Tan, Yu Pei. "The development of Lactococcus lactis as an antimicrobial agent." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/39143/1/Yu_Pei_Tan_Thesis.pdf.

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Non-pathogenic lactic acid bacteria are economically important Gram-positive bacteria used extensively in the food industry. Due to their “generally regarded as safe” status, certain species from the genera Lactobacillus and Lactococcus are also considered desirable as candidates for the production and secretion of recombinant proteins, particular those with therapeutic applications. The hypothesis examined by this thesis is that Lactococcus lactis can be modified to be an effective antimicrobial agent. Therefore, the aims of this thesis were to investigate the optimisation of the express

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3

Gründel, Anne. "Funktion glykolytischer Enzyme von Mycoplasma pneumoniae in der Wirt-Erreger-Interaktion." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-213500.

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Mycoplasma pneumoniae ist ein parasitär lebendes Bakterium, das eine atypische Pneumonie beim Menschen verursacht. Aufgrund seiner geringen Genomgröße besitzt dieser Organismus einen eingeschränkten Metabolismus sowie eine limitierte Zahl an Pathogenitätsfaktoren. Dennoch ist dieser Mikroorganismus perfekt an seinen Wirt angepasst und es war zu vermuten, dass neben dem komplexen Adhäsionsapparat von M. pneumoniae auch glykolytische Enzyme eine Rolle bei der Interaktion mit humanen Zellen spielen. Diese Enzyme sind maßgeblich bei intrazellulär ablaufenden Stoffwechselprozessen beteiligt. Es wur

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4

Owen, Jo. "Structural and functional studies of fibulin-1 EGF domains." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270656.

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5

McCosker, Helen Clare. "Prognostic significance of IGF and ECM induced signalling proteins in breast cancer patients." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/53580/1/Helen_McCosker_Thesis.pdf.

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Breast cancer is a leading contributor to the burden of disease in Australia. Fortunately, the recent introduction of diverse therapeutic strategies have improved the survival outcome for many women. Despite this, the clinical management of breast cancer remains problematic as not all approaches are sufficiently sophisticated to take into account the heterogeneity of this disease and are unable to predict disease progression, in particular, metastasis. As such, women with good prognostic outcomes are exposed to the side effects of therapies without added benefit. Furthermore, women with aggres

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6

López, Ceballos Pablo. "Elucidating how protein turnover in cell-ECM adhesion stabilizes tissue structure during development." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57622.

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Morphogenesis is the process by which cells rearrange to form complex three dimensional structures. Cell to extracellular matrix (ECM) adhesion, primarily mediated by Integrins, is essential for the formation and maintenance of tissue architecture. A critical way to regulate cell-ECM adhesion is by modulating the turnover of Integrins and their adhesion complex, and thereby modulating the stability of Integrin-based adhesions. We previously showed that mechanical force stabilizes Integrin-based adhesions during development by modulating Integrin turnover. Here, we extend our studies to underst

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7

Osta, Muhammad Samir Ahmed. "Characterisation of ECM protein processing mechanisms underlying simple peritoneal sclerosis and encapsulating peritoneal sclerosis." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/11406/.

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Introduction and hypothesis: Peritoneal dialysis (PD) is an important option for renal replacement therapy. Peritoneal sclerosis (PS) limits PD duration due to loss of ultrafiltration (UF) capacity, while about 3% of PD patients experience a condition termed encapsulating peritoneal sclerosis (EPS). In many fibrotic diseases reduced Extracellular matrix (ECM) breakdown due to lowered matrix metalloproteinase (MMP) activity occurs, often from over-expression of tissue inhibitors of MMP (TIMPs) that underlie fibrotic remodeling. Furthermore, recent application of 2D gel proteomics on peritoneal

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8

Gandhi, Neha Sureshchandra. "Molecular modelling of the interactions of complex carbohydrates with proteins." Thesis, Curtin University, 2011. http://hdl.handle.net/20.500.11937/2027.

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Glycosaminoglycans (GAGs) are ubiquitous complex carbohydrate molecules present on the cell surfaces and in extracellular matrices (ECM) of vertebrate and invertebrate tissues. The interactions of sulphated GAGs such as heparin and heparan sulphate (HS) with numerous immunologically-relevant proteins is now attracting considerable interest as a source of new therapeutics for the treatment of infectious diseases, inflammation and allergies, and cancers. Various computational molecular modelling methods are being employed to determine the nature of the interactions of heparin oligosaccharides wi

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9

Lundberg, Ida. "Fibroblasts and ECM in colorectal cancer : Analysis of subgroup specific protein expression and matrix arrangement." Thesis, Umeå universitet, Patologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-85606.

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The tumor microenvironment is important for tumor growth and progression, where the cancer associated fibroblast (CAF) is one central cell type. The CpG island methylator phenotype (CIMP) divides colorectal cancer (CRC) into three subgroups and in this study we investigate how the different CIMP-groups and adjacent fibroblasts affect each other. This was done with the aim of finding CIMP-specific markers and to see if different tumor-fibroblast interactions result in differently invasive tumors. Here we report that CIMP-negative tumors have increased expression of fibronectin, while CIMP-high

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10

Waters, Timothy Richard. "Studies on the Eco RV restriction endonuclease using oligodeoxynucleotides containing modified bases." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385336.

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11

Chan, Ien. "The role of extracellular matrix protein 1 (ECM1) in human skin." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423043.

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12

Tian, Wang, la Vega Montserrat Rojo de, Cody J. Schmidlin, Aikseng Ooi, and Donna D. Zhang. "Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2–related factors 1 and 2 (NRF1 and NRF2)." AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2018. http://hdl.handle.net/10150/627124.

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Nuclear factor erythroid-2-related factor 1 (NRF1) and NRF2 are essential for maintaining redox homeostasis and coordinating cellular stress responses. They are highly homologous transcription factors that regulate the expression of genes bearing antioxidant-response elements (AREs). Genetic ablation of NRF1 or NRF2 results in vastly different phenotypic outcomes, implying that they play different roles and may be differentially regulated. Kelch-like ECH-associated protein 1 (KEAP1) is the main negative regulator of NRF2 and mediates ubiquitylation and degradation of NRF2 through its NRF2-ECH

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13

ZANUT, ALESSANDRA. "Development of microarrays for protein and genetic screening with an Electrochemical and Elctrochemiluminescence-based transduction scheme." Doctoral thesis, Università degli Studi di Trieste, 2017. http://hdl.handle.net/11368/2908111.

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Considering the increasing need for sensing elements that is emerging in different fields and applications, particularly in relation to the Internet of Things, electrochemical sensors and biosensors, also for their exceptional attributes, such as being easy-to-operate, economical, sensitive, portable, are candidates to become essential pillars in future scenarios and to play a significant role biomedical and environmental monitoring. Electrochemical and electrochemiluminescent sensors, are devices capable of detecting molecules and biomolecules in solutions and determining the concentration th

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Thorogood, Harry. "The Eco RV restriction endonuclease : an investigation using resonance raman spectroscopy and oligonucleotide phosphorothioates." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361576.

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15

Khaghani, Seyed Ali. "Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins : effect of transforming growth factor-beta (TGF-β1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins". Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/5371.

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Articular cartilage is an avascular and flexible connective tissue found in joints. It produces a cushioning effect at the joints and provides low friction to protect the ends of the bones from wear and tear/damage. It has poor repair capacity and any injury can result pain and loss of mobility. One of the common forms of articular cartilage disease which has a huge impact on patient's life is arthritis. Research on cartilage cell/tissue engineering will help patients to improve their physical activity by replacing or treating the diseased/damaged cartilage tissue. Cartilage cell, called chond

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16

Sefat, Farshid. "Cell engineering of human bone monolayers and the effect of growth factors and microcontact printed ECM proteins on wound healing : the role of ECM proteins, TGFβ-1, 2 and 3 and HCl/BSA in cellular adhesion, wound healing and imaging of the cell surface interface with the widefield surface plasmon microscope". Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/5758.

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Bone repair is modulated by different stimuli. There is evidence that the Transforming Growth Factor-beta (TGF-β) super-family of cytokines have significant effects on bone structure by regulating the replication and differentiation of chondrocytes, osteoblasts and osteoclasts. There is also significant evidence that interactions with extracellular matrix molecules also influence cell behaviour. This study aimed at determining the role of the TGF-βs, Collagen type I, Fibronectin and Laminin in bone cell behaviour. To do this MG63 bone cells were used to examine cell adhesion and alignment to d

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17

Khaghani, Seyed A. "Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins. Effect of transforming growth factor-beta (TGF-¿1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/5371.

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Articular cartilage is an avascular and flexible connective tissue found in joints. It produces a cushioning effect at the joints and provides low friction to protect the ends of the bones from wear and tear/damage. It has poor repair capacity and any injury can result pain and loss of mobility. One of the common forms of articular cartilage disease which has a huge impact on patient¿s life is arthritis. Research on cartilage cell/tissue engineering will help patients to improve their physical activity by replacing or treating the diseased/damaged cartilage tissue. Cartilage cell, called chon

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18

Sefat, Farshid. "Cell engineering of human bone monolayers and the effect of growth factors and microcontact printed ECM proteins on wound healing. The role of ECM proteins, TGF¿-1, 2 and 3 and HCl/BSA in cellular adhesion, wound healing and imaging of the cell surface interface with the widefield surface plasmon microscope." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/5758.

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Bone repair is modulated by different stimuli. There is evidence that the Transforming Growth Factor-beta (TGF-¿) super-family of cytokines have significant effects on bone structure by regulating the replication and differentiation of chondrocytes, osteoblasts and osteoclasts. There is also significant evidence that interactions with extracellular matrix molecules also influence cell behaviour. This study aimed at determining the role of the TGF-¿s, Collagen type I, Fibronectin and Laminin in bone cell behaviour. To do this MG63 bone cells were used to examine cell adhesion and alignment to

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19

Fátima, Luciana Alves de. "Análise diferencial da expressão gênica e proteica no corpo lúteo de bovinos submetidos a tratamentos com eCG." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-05082013-174714/.

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A gonadotrofina coriônica equina (eCG) tem sido utilizada em programas de sincronização para inseminação artificial em tempo fixo e normalmente promove o aumento do volume do corpo lúteo e a da produção de progesterona. Além disso, esta mesma gonadotrofina pode ser utilizada para superovulação. Desse modo, hipóteses relativas aos mecanismos pelos quais gonadotrofinas exógenas alteram as funções celulares nos corpos lúteos resultantes foram formuladas. Para testar tais hipóteses, 18 vacas (Bos indicus) foram divididas em grupos: controle (n=5), estimulado (n=6) e superovulado (n=7) e a ovulação

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20

Cruz, Juliana Nunes da. "Hidrolisado proteico da semente de cupuaçu como fonte de peptídeos inibidores da enzima conversora da angiotensina I." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/9/9131/tde-29042015-100916/.

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Peptídeos com ação inibitória da enzima conversora da angiotensina I (ECA) podem ser obtidos a partir de diversos alimentos e exercer efeito anti-hipertensivo. O cupuaçu (Theobroma grandiflorum S.), fruto nativo da Amazônia, possui sementes comestíveis contendo proteína de reserva similar à do cacau (Theobroma cacao L.), as quais parecem ser fonte de peptídeos inibidores da ECA. Desse modo, o objetivo deste trabalho foi investigar in vitro a ocorrência de peptídeos inibidores da ECA no hidrolisado proteico da semente de cupuaçu obtido por ação da Alcalase. O hidrolisado revelou o desaparecimen

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21

Eriksson, Jenny. "Studies of Eosinophil Cationic Protein (ECP) in vivo and in vitro : Impact of Genetic and Posttranslational Modifications." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8261.

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22

Karawajczyk, Malgorzata. "Mechanisms of granule protein mobiliation in blood eosinophils." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-502.

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<p>Serum levels of eosinophil granule proteins namely ECP, EPO and EPX, which are stored in the matrix of specific granules, were shown to correlate with the course of disease in disorders involving eosinophils. The concentration of eosinophil proteins in serum is the result of their release <i>in vivo</i> and <i>ex vivo</i> during the sampling procedure. Generally, eosinophils release the content of their specific granules in three ways: exocytosis, piecemeal degranulation (PM) or cytolysis. Which of them is operating in circulating eosinophils has not yet been defined. The aim of this thesis

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23

Silva, Daniel João Pires de Mendonça. "Crosslinking strategies to improve properties of protein-based nanofibrous membranes." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22780.

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Mestrado em Biotecnologia<br>O objetivo deste estudo foi desenvolver uma matriz nanofibrosa e ecológica de gliadina de trigo para ser submetida e testada a agentes de reticulação alternativos, calor, genipina, ácido cítrico e o convencional e tóxico glutaraldeído, de modo a que as conhecidas limitações estruturais e de resistência mecânica de fibras proteicas pudessem ser ultrapassadas, nomeadamente quando utilizadas em ambiente aquoso. Nanofibras lisas, bem definidas e sem grânulos de gliadina, com um diâmetro médio de 665 nm, foram produzidas por eletrofiação a uma concentração otimizada de

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24

Xu, Xiaoyan. "Granulocyte Adhesion to Matrix Proteins and the Effect on the Release of Granule Proteins : Development of a Simple Method and its Application in Experimental and Clinical Studies." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5112-8/.

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Krauspenhar, Bruna. "Polimorfismos gen?tico e proteico da enzima conversora de angiotensina na s?ndrome de pr?-ecl?mpsia." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2015. http://tede2.pucrs.br/tede2/handle/tede/6064.

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Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2015-05-28T11:40:36Z No. of bitstreams: 1 469525 - Texto Completo.pdf: 2925199 bytes, checksum: d0ce1f2f0c3cdc1d309d3f09e9a7d239 (MD5)<br>Made available in DSpace on 2015-05-28T11:40:36Z (GMT). No. of bitstreams: 1 469525 - Texto Completo.pdf: 2925199 bytes, checksum: d0ce1f2f0c3cdc1d309d3f09e9a7d239 (MD5) Previous issue date: 2015-03-02<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES<br>Introduction: Preeclampsia is a disease characterized as high maternal and fetal morbidity and mortality,

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Grasman, Jonathan M. "Designing Fibrin Microthread Scaffolds for Skeletal Muscle Regeneration." Digital WPI, 2015. https://digitalcommons.wpi.edu/etd-dissertations/18.

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Volumetric muscle loss (VML) typically results from traumatic incidents; such as those presented from combat missions, where soft-tissue extremity injuries account for approximately 63% of diagnoses. These injuries lead to a devastating loss of function due to the complete destruction of large amounts of tissue and its native basement membrane, removing important biochemical cues such as hepatocyte growth factor (HGF), which initiates endogenous muscle regeneration by recruiting progenitor cells. Clinical strategies to treat these injuries consist of autologous tissue transfer techniques, re

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Sánchez, Tatiana Marlene Galvez. "Avaliação comparativa das proteinas de fusão cmx e ecmx no teste de mantoux para o diagnóstico de tuberculose." Universidade Federal de Goiás, 2017. http://repositorio.bc.ufg.br/tede/handle/tede/7004.

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Submitted by Cássia Santos (cassia.bcufg@gmail.com) on 2017-03-24T11:22:47Z No. of bitstreams: 2 Dissertação - Tatiana Marlene Galvez Sánchez - 2017.pdf: 3124839 bytes, checksum: 942aa6d4fa9aa30babb4eb0d7e04a805 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-03-24T12:39:25Z (GMT) No. of bitstreams: 2 Dissertação - Tatiana Marlene Galvez Sánchez - 2017.pdf: 3124839 bytes, checksum: 942aa6d4fa9aa30babb4eb0d7e04a805 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427

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Cunha, Hilda Helena Souza da. "Protein?ria e ?cido ?rico s?rico maternos em pacientes com s?ndrome de HELLP." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2012. http://tede2.pucrs.br/tede2/handle/tede/1708.

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Made available in DSpace on 2015-04-14T13:35:36Z (GMT). No. of bitstreams: 1 443764.pdf: 1879751 bytes, checksum: a84345f48429752c882a6b33df97af04 (MD5) Previous issue date: 2012-08-28<br>Objective: To evaluate the association of maternal serum uric acid (UA) and proteinuria with clinical and demographic data of pregnant women with preeclampsia syndrome (PES) complicated by HELLP syndrome. Methods: One hundred and nine pregnant women were divided into two groups: group 1 - HELLP pregnant women with PES complicated by HELLP syndrome (n=64); group 2 PES pregnant women with PES but no HEL

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Pozza, Roberta. "Acur?cia diagn?stica da raz?o protein?ria/creatinin?ria em pacientes com suspeita de s?ndrome de pr?-ecl?mpsia : revis?o sistem?tica e metan?lise de estudos diagn?sticos." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2010. http://tede2.pucrs.br/tede2/handle/tede/1649.

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Made available in DSpace on 2015-04-14T13:35:20Z (GMT). No. of bitstreams: 1 435056.pdf: 575781 bytes, checksum: f9580c906dcf3a01a8f3076eee53e643 (MD5) Previous issue date: 2010-12-17<br>Background: The laboratory gold standard test for identification of proteinuria in pregnant women is its measurement in a 24-hour urine sample. Urine protein-to-creatinine ratio in an isolated sample has been suggested as an option to a 24-hour urine collection. Proteinuria is a key feature of the preeclampsia syndrome. The current study aims at estimating the diagnostic accuracy of urine protein-to-creatini

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Chan, Grace Lap-Yu. "Propafenone pharmacokinetics : GLC-ECD analysis, metabolic induction by phenobarbital in non-smoking and smoking healthy volunteers, protein binding, pharmacodynamics in patients." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/29064.

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Propafenone (PF) is a new class I antiarrhythmic agent used to treat supraventricular and ventricular tachyarrhythmias. This thesis reports: a) an in vitro protein binding study of PF in normal and uremic sera; b) a drug-drug interaction study of PF and phenobarbital in healthy human subjects and c) a concentration-response relationship study of PF in patients. In order to conduct these studies, it was necessary to develop a sensitive and accurate assay method for the measurement of PF in biological fluids. A capillary column electron-capture detection gas-liquid chromatographic (GLC-ECD) as

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Hebestreit, Johann Philipp. "Untersuchungen zum Synergismus von Saponinen und Toxinen bei in vitro kultivierten Säugetierzellen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2005. http://dx.doi.org/10.18452/15180.

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Im Verlauf der Untersuchungen von Agrostemma githago L. var. githago, eines bekannten giftigen Vertreters der Caryophyllaceae, verwendeten wir neben Agrostemmasaponin das Saponinum album aus Gypsophila paniculata L., ebenfalls mit Gypsogenin (3b-Hydroxy-Olean-12-en-23-al-28-Säure) als Aglykon. Eine Kombination dieser Saponinderivate (3 µg/ml) mit einer Formylfunktion an Position C4 des Aglykons in Kombination mit RIPs und anderen natürlichen Toxinen zeigte eine kooperative Toxizität an ECV 304-Zellen. Ribosomen-inaktivierende Proteine (RIPs; EC Nr. 3.2.2.22) sind eine heterogene Familie von st

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Huang, Kai Ting, and 黃楷婷. "The Structure and Function of ECM Protein in Mitochondrial Enlargement and Clustering." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/17811912851655273254.

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碩士<br>國立清華大學<br>生物科技研究所<br>103<br>Drosophila ECM is a CDGSH Ion-Sulfur binding domain containing protein that contains a CDGSH in C-terminal region. In this study, ECM is located on mitochondria at same direction. Overexpression of ECM dramatically causes Enlarged and Clustering Mitochondria in Drosophila S2 cell and mammalian HeLa cell so that we named it as ECM. We defined four regions in ECM, ECM-MH-1 and ECM-MH-2 from their similar and different region as N-terminal, transmembrane region, hinge region and CDGSH region. From the domain swap among ECM-MH-1, ECM-MH-2 and ECM, we found N-termi

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Lu, Yung-Yu. "Functional Studies of a Stress Protein Family: Subcellular Localizations of AtHVA22a-e Proteins in Arabidopsis." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2507200800293900.

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Leu, Jiann-Horng. "Cloning and characterization of apoptosis-related proteins from Penaeus monodon: Inhibitor of apoptosis protein (IAP) and caspase." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2405200713435400.

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Chen, Chung-Hong, and 陳俊宏. "The study of the effects of biodegradable polymers and ECM proteins on chondrocyte adhesion, proliferation and gene expression." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/27310293409062892297.

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碩士<br>國立臺灣大學<br>化學工程學研究所<br>92<br>The goal of this study was to compare the performance of chondro- cytes in adhesion, proliferation and gene expression of chondrocytes when they were cultivated on different biodegradable polymers. Four kinds of biodegradable polymers was used in this study, including PDLLA, PLLA, PLGA, and PCL, which were made by using the solvent- casting method, and chondrocytes were cultured on the polymer films. Cell adhesion on day 1, cell proliferation and gene expression on day 4 and day 7 were investigated. The results show that chondrocytes prolife- rated better on P

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Hsieh, Hui-Min, and 謝惠泯. "The Influence of ECM Protein by Adding High Concentration Glucose and Vitamin C、E in Culture Endothelial Cell Study." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/97997969237905290639.

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碩士<br>中山醫學院<br>營養科學研究所<br>87<br>Abstract In this study is to explore the influence of adding high concentrated glucose and antioxidant C、E to Fibronectin(FN) a ECM protein and Quantitative changed of total cellular protein. Furthermore to examine the relationship of TGF-s and AGE to biosynthesis of FN in culture study. Methodology of experiment: 105/well cells were incubated in 24 well plate. Each well contains M-199+10%FCS. M-199+10%FCS+30mM glucose (high physiological conc.) M-199+10%FCS+5mM glucose (normal physiological conc.) vitamin C (0.01mM.、0.05mM) and vitamin E(0

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佐藤, 好隆, and Yoshitaka Sato. "Degradation of Phosphorylated p53 by Viral Protein-ECS E3 Ligase Complex." Thesis, 2013. http://hdl.handle.net/2237/18598.

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Kai-Fa, Huang. "Post-Translationally Pyroglutamate Formation on Proteins: Studies on protein production, crystal structures, catalysis mechanism, inhibition and pathophysiology of human glutaminyl cyclase." 2006. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2501200613275100.

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GIARDINA, MARIA MIRIAM. "Analysis of “Streptococcal SUrface REpeat” domain (SSURE) from Streptococcus surface proteins and investigation of their binding properties to Extracellular Matrix (ECM) molecules." Doctoral thesis, 2020. http://hdl.handle.net/11570/3182323.

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SSURE are domains found in proteins expressed by various streptococcal species that were initially described by their ability to bind extracellular matrix protein (Bumbaca, 2004, Jedrzajas,2007). The scope of this thesis is to examine the interactions between different SSURE domains and ECM in comparison with other ECM components. In particular, in the course of these studies, I have focused on the use of Atomic Force Microscopy to study interactions between recombinant SSURE domains of S. pneumoniae and S. gordonii .

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Hsu, Chia-Ming. "Mining Dense Overlapping Subgraphs in Weighted Protein-Protein Interaction Networks." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1807200716394500.

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Tsai, Meng-Jia. "Protein-Protein Interaction Prediction with Identification of Putative Interaction Patterns." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2208200715581500.

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Huang, Tao-Wei. "Prediction of Human Protein-Protein Interactions Using Support Vector Machines." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-0910200714331600.

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Li, Chia-Feng, and 李嘉峰. "The Mechanism of Kelch-Like ECH-Associated Protein 1( Keap1) in Lung Adenocarcinoma Migration." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/54783667330135466675.

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碩士<br>國立臺灣大學<br>毒理學研究所<br>99<br>Kelch-loke ECH-associated protein 1(KEAP1) is a redox-dependent substrate adaptor protein which interact with cul3 ubiquitin ligase complex to degradate NRF2(NF-E2-related factor 2). The decreased expression of KEAP1 will enhance NRF2 expression and accumulate in the nucleus, where binding with antioxidant responsive element(ARE) and activate the antioxidative enzyme expression. Here we observed the KEAP1 expression had inversely correlation with cell migration ability. So we suggesting that the NRF2 target gene may provide advantage for cancer cell progression

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Chung, Amy S. "Macrophage matrix metalloproteinase-2/-9 and interleukin-1[beta] gene and protein expression following adhesion to ECM-derived multifunctional matrices via integrin complexation." 2006. http://catalog.hathitrust.org/api/volumes/oclc/71354916.html.

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Thesis (M.S.)--University of Wisconsin--Madison, 2006.<br>Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 59-63).

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Chen, Chiuan-Jung. "Protein Loop Modeling." 2004. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1507200400502700.

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Fang, Chiung-Ying. "Characterization of post-translational modification and protein-protein interaction of RNA-binding protein 1, Rbp1p, in Saccharomyces cerevisiae." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2307200711033800.

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Huang, Pei-Yi, and 黃珮儀. "Functional Association of SNP/InDel Variations in Human Reference Proteins by Evidence-Based Mining (EBM)." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/84502866398962494459.

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碩士<br>國立陽明大學<br>衛生資訊與決策研究所<br>92<br>Identification of genes, whose products play a major role in human disease, is a major aim in the analysis of human genome. Genotypic variations have been proved to be the major cause of genetic disease and cancer. Recently, the common variations of gene sequence, such as SNP and InDel, have been proved to be related to phenotypical alterations or disorders as well. Proteins are the elements contributing to our physiology and molecular function. Their function might be altered if primary amino acid had changed. There are various techniques used to discover

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Peng, Chin-Lin. "ProtExt: a Web-based Protein-protein Interaction Extraction System for PubMed Abstracts." 2004. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1407200403401600.

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Wu, Tsung-Shung. "Functional characterization of Arf-like protein, ARL5 and its interacting protein EB1." 2005. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-0908200521130700.

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Yan, Min-Zhe. "Web-Based Information Extraction System - A Case Study on Protein-Protein Interactions." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0020-3107200808135500.

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