Log in

Relevant bibliographies by topics / Economic aspects of Cerebrovascular disease / Journal articles

To see the other types of publications on this topic, follow the link: Economic aspects of Cerebrovascular disease.

Journal articles on the topic 'Economic aspects of Cerebrovascular disease'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Economic aspects of Cerebrovascular disease.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Geltser, B. I., I. G. Kurpatov, V. N. Kotelnikov, and Yu V. Zayats. "Chronic obstructive pulmonary disease and cerebrovascular diseases: functional and clinical aspect of comorbidity." Terapevticheskii arkhiv 90, no. 3 (March 15, 2018): 81–88. http://dx.doi.org/10.26442/terarkh201890381-88.

Full text

Abstract:

Literature data of chronic obstructive pulmonary disease (COPD) and cerebrovascular diseases (CVD) comorbidity are represented in this review. Key aspects of this interaction and its importance for clinical medicine have been considered. CVD and COPD are the main mortality factors in adults, which contribute to great economic wastes. The incidence of chronic cerebral ischemia for COPD patients is almost three times as high as for general population. The incidence of ischemic stroke for COPD patients is 1,2 times higher than in general population. For hemorrhagic stroke and subarachnoid haemorrhages, this figures are 1,3 and 1,46 respectively. Chronic systemic inflammation, tissue hypoxia and oxidative stress play the crucial role in respiratory and cerebrovascular comorbidity. Metabolites of these processes (especially proinflammatory cytokines, reactive oxygen species, C-reactive protein and some neurotrophins) increase the permeability of blood-brain barrier, destroy brain cells and activate atherogenesis in pre - and intracerebral arteries. Endothelial dysfunction affects autoregulation of cerebral circulation. Systemic symptoms of COPD are closely associated with different structural-functional disorders of the brain such as reduction in white matter integrity, grey matter volume reduction and cerebral microbleeds. Also, venous encephalopathy is developed as a result of intrathoracic pressure elevation and stasis in superior vena cava system. These processes result in neurological symptomatology. The intensity of symptoms depends on COPD severity. The occurrence of cognitive impairment, psychic tension, depression, panic disorders also increases. However COPD and CVD comorbidity is an important problem of modern medicine, pathophysiologic mechanisms and clinic aspects of this problem remain unresolved. Understanding of their role opens perspectives for rational pharmacotherapy.

APA, Harvard, Vancouver, ISO, and other styles

2

Gayfullina, R. F., M. N. Katina, F. F. Rizvanova, O. A. Kravtsova, and A. A. Rizvanov. "Role of genetic polymorphism in the pathogenesis of cerebrovascular disease." Kazan medical journal 93, no. 4 (August 15, 2012): 663–67. http://dx.doi.org/10.17816/kmj1567.

Full text

Abstract:

Presented was a review of the most recent literature devoted to the main genes responsible for the formation of atherothrombosis of the cerebral vessels. The aim was to analyze the data in the literature regarding several genetic factors responsible for the development of cerebrovascular disease, particularly ischemic stroke. Conducted was an electronic search of full-text and abstract-only versions of articles, which cover the aspects of genetic susceptibility to ischemic stroke, according to the databases PUBMED, OMIM and GENE using the following main keywords: «cerebrovascular disease», «ischemic stroke», «cerebral atherosclerosis», «gene polymorphism», «mutation». Medical diagnostics today has modern technologies of genotyping, which make it possibe to accurately determine the genotype of a person, thus opening up wide prospects for the development of personalized medicine. The majority of genetic variations is due to single nucleotide substitutions that lead to quantitative changes in expression or affect the biological properties of the proteins. Approximately 10 million single nucleotide polymorphisms are known, however their biological significance is not always obvious. Currently hereditary predisposition to atherosclerosis is being actively studied, identified were the genetic variants of genes of blood lipid metabolism, endothelial dysfunction, hemostatic system, and proteins involved in platelet aggregation and thrombosis. An individual «genetic passport» makes it possible to determine the risk factors for atherosclerotic lesions of blood vessels in a specific individual long before the development of the disease. Determination and investigation of groups of genes that are responsible for the development of atherosclerosis in people living in specific areas is still of utmost relevance. Based on these studies it is possible to establish specific test systems for the Republic of Tatarstan for diagnosing predisposition to the development of certain forms of atherosclerosis, the widespread introduction of which will significantly reduce the mortality and disability of the population, the economic and social damage.

APA, Harvard, Vancouver, ISO, and other styles

3

M., Sarin S., and Jayasree A. K. "Health problems in geriatric population of age group ≥70 years in rural Kerala, India: a cross sectional study." International Journal of Research in Medical Sciences 7, no. 9 (August 27, 2019): 3486. http://dx.doi.org/10.18203/2320-6012.ijrms20193933.

Full text

Abstract:

Background: The proportion of elderly population is increasing considerably world over. The health and socio-economic issues of this section is to be considered separately and in depth insights about them is needed for formulating elderly friendly health policy. This study intends toidentify the important health concerns of elderly population above the age group of 70 years in a rural area in North Kerala, India.Methods: It is a community based cross-sectional descriptive study involving all individuals above the age group of 70 years in a randomly selected panchayath ward from rural North Kerala. The data regarding demography, socioeconomic aspects, medical history, access to health care and treatment of chronic illnesses were collected through interview of study participants by a trained health care volunteer using a pre-validated questionnaire.Results: A total of 93 individuals above the age group of 70 years were included in the study out of which 63% were females and 37% males. In the study population 55.9% of the elderly were widowed and 87.1 % were staying along with their children. Almost 75% of the elderly received social welfare pension from government agencies and 14.3% received service pensions. 67.74% of the study population were hypertensive and 35.56% were diabetic. Other health issues included arthritis, coronary artery disease, chronic kidney disease, genito urinary symptoms and cerebrovascular accident.Conclusion: The study provide valuable insights into the health and social issues of elderly in Kerala and points to the importance of formulating an elderly friendly health policy in the state.

APA, Harvard, Vancouver, ISO, and other styles

4

Radovic, Vesna. "Use of beta blockers in various clinical states." Medical review 64, no. 1-2 (2011): 55–60. http://dx.doi.org/10.2298/mpns1102055r.

Full text

Abstract:

Introduction. According to the convincing evidence, a decline in mortality rate has been achieved with beta-blockers in patients with an acute myocardial infarction and in post-infarction follow-up. In fact, there has been a clear reduction of sudden coronary death. The necessary condition for the efficiency of beta-blockers is an early use. They are also a medication of choice for angina after an infarction. The objective of this work was to evaluate the use of beta-blockers after a myocardial infarction in various clinical states and to eliminate doubts concerning their prescription. Beta blockers Even in conditions considered contraindications for administration of beta blockers such as old age, diabetes, non-Q-wave myocardial infarction, peripheral vascular disease, arterial disease, heart insufficiency, ventricular arrhythmias, renal disease, chronic obstructive pulmonary disease, asthma and depression, patients benefit from beta blockers when they are given along with a right choice of the medication and a regular follow-up of the patient. Preference is given to cardioselective beta blockers in patients with diabetes or lung disease. Beta-blockers do not cause long-term lipid alterations. Therefore, the matter of clinically significant alterations of lipids or blood glucose levels should not need further consideration as a problem of the treatment of diabetics. Discussion and conclusion. Investigations have proved that the use of beta-blockers reduces the development of cerebrovascular accidents, heart insufficiency and hypertension. Despite strong arguments and numerous recommendations, beta-blockers have not been accepted to a sufficient extent as an integral part of treatment of acute coronary syndrome and related diseases, to the detriment of many lost lives and in spite of favourable pharmaco-economic aspect.

APA, Harvard, Vancouver, ISO, and other styles

5

Schwartz, Joseph A. "Neurobehavioral Aspects of Cerebrovascular Disease." Psychosomatics 33, no. 3 (August 1992): 358. http://dx.doi.org/10.1016/s0033-3182(92)71981-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Alberts, M. J. "Genetic aspects of cerebrovascular disease." Stroke 22, no. 2 (February 1991): 276–80. http://dx.doi.org/10.1161/01.str.22.2.276.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Neuren, A. P. "Neurobehavioral Aspects of Cerebrovascular Disease." Neurology 41, no. 12 (December 1, 1991): 2016. http://dx.doi.org/10.1212/wnl.41.12.2016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Folstein, Marshal F. "Neurobehavioral Aspects of Cerebrovascular Disease." Journal of Nervous and Mental Disease 181, no. 2 (February 1993): 141. http://dx.doi.org/10.1097/00005053-199302000-00016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Toole, James F. "Neurobehavioral aspects of cerebrovascular disease." Journal of the Neurological Sciences 108, no. 1 (March 1992): 118. http://dx.doi.org/10.1016/0022-510x(92)90198-t.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Marshall, J. "BOOK REVIEWS: Neurobehavioural Aspects of Cerebrovascular Disease." Journal of Neurology, Neurosurgery & Psychiatry 54, no. 12 (December 1, 1991): 1125–26. http://dx.doi.org/10.1136/jnnp.54.12.1125-a.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Shovlin, C. L. "Genetic Aspects of Cerebrovascular Malformations." Interventional Neuroradiology 6, no. 2 (June 2000): 107–11. http://dx.doi.org/10.1177/159101990000600204.

Full text

Abstract:

In the last decade there have been fundamental advances in our understanding of the pathogenesis of vascular malformations. These advances have resulted from the application of molecular methods to identify disease genes, rather than from immunohistochemical or physiological studies. This presentation reviews the genetic basis of a variety of cerebral vascular malformations which occur as part of well-characterised diseases inherited in an autosomal dominant manner. These highlight the diversity of mechanisms which can perturb vascular development, and should have significant implications for the development of new therapies.

APA, Harvard, Vancouver, ISO, and other styles

12

Kim, I. V., E. V. Bochkareva, and Yu Ya Varakin. "Cerebrovascular disease screening in general medical practice: methodological aspects." Profilakticheskaya meditsina 20, no. 5 (2017): 59. http://dx.doi.org/10.17116/profmed201720559-64.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Pula, John H., and Carlen A. Yuen. "Eyes and stroke: the visual aspects of cerebrovascular disease." Stroke and Vascular Neurology 2, no. 4 (July 6, 2017): 210–20. http://dx.doi.org/10.1136/svn-2017-000079.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Catto, A. J. "Genetic aspects of the hemostatic system in cerebrovascular disease." Neurology 57, Supplement 2 (September 1, 2001): S24—S30. http://dx.doi.org/10.1212/wnl.57.suppl_2.s24.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Hennerici, Michael G. "New Aspects of Calcium Antagonists for Treatment of Cerebrovascular Disease." Journal of Cardiovascular Pharmacology 18 (1991): S59—S63. http://dx.doi.org/10.1097/00005344-199106191-00011.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Hennerici, Michael G. "New Aspects of Calcium Antagonists for Treatment of Cerebrovascular Disease." Journal of Cardiovascular Pharmacology 18 (1991): S59—S63. http://dx.doi.org/10.1097/00005344-199118101-00011.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Maresova, Petra, Hana Mohelska, Josef Dolejs, and Kamil Kuca. "Socio-economic Aspects of Alzheimer's Disease." Current Alzheimer Research 12, no. 9 (October 19, 2015): 903–11. http://dx.doi.org/10.2174/156720501209151019111448.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Reckless, J. P. D. "Economic aspects of cardiovascular disease prevention." Atherosclerosis 109, no. 1-2 (September 1994): 81. http://dx.doi.org/10.1016/0021-9150(94)93340-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Magalhães, Nathalia Noyma Sampaio, Tássia Mariana Moreira da Paz, Renato Lourenço de Medeiros, Thais Sette Espósito, Olivia Franco dos Santos, Ianka Cristina Ernesto, Marina Schuffner Silva, and Daniela de Oliveira Werneck Rodrigues. "Doença Cerebrovascular: Aspectos de uma população com Doença Falciforme / Cerebrovascular Disease: Aspects of a population with sickle cell disease." Brazilian Journal of Health Review 3, no. 5 (2020): 15440–50. http://dx.doi.org/10.34119/bjhrv3n5-320.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Grotta, James C. "Clinical Aspects of the Use of Calcium Antagonists in Cerebrovascular Disease." Clinical Neuropharmacology 14, no. 5 (October 1991): 373–90. http://dx.doi.org/10.1097/00002826-199110000-00001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Griessenauer, Christoph J., Sean Farrell, Atom Sarkar, Ramin Zand, Vida Abedi, Neil Holland, Andrew Michael, et al. "Genetic susceptibility to cerebrovascular disease: A systematic review." Journal of Cerebral Blood Flow & Metabolism 38, no. 11 (September 5, 2018): 1853–71. http://dx.doi.org/10.1177/0271678x18797958.

Full text

Abstract:

Investigation of genetic susceptibility to cerebrovascular disease has been of growing interest. A systematic review of human studies assessing neurogenomic aspects of cerebrovascular disease was performed according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. Any association study exploring genetic variants located in the exome associated with one of the major cerebrovascular diseases with at least 500 subjects was eligible for inclusion. Of 6874 manuscripts identified, 35 studies met the inclusion criteria. Most studies of interest focused on ischemic stroke and cerebrovascular occlusive disease. Large cohort genetic association studies on hemorrhagic cerebrovascular disease were less common. In addition to rare, well-established monogenic conditions with significant risk for cerebrovascular disease, a number of genetic variants are also relevant to cerebrovascular pathogenesis as part of a multifactorial process. The 45 polymorphisms identified were located in genes involved in processes related to endothelial and vascular health (15 (33.4%) variants), plasma lipid metabolism (10 (22.2%) variants), inflammation (9 (20%) variants), coagulation (3 (6.7%) variants), and blood pressure modulation (2 (4.4%) variants), and other (6 (13.3%) variants). This work represents a comprehensive overview of genetic variants in the exome relevant to ischemic and hemorrhagic stroke pathophysiology.

APA, Harvard, Vancouver, ISO, and other styles

22

Levy, E. I., A. S. Boulos, B. R. Bendok, M. B. Horowitz, S. H. Kim, A. I. Qureshi, L. R. Guterman, and L. N. Hopkins. "Intracranial Stenting for Cerebrovascular Pathology." Rivista di Neuroradiologia 16, no. 1 (February 2003): 139–48. http://dx.doi.org/10.1177/197140090301600118.

Full text

Abstract:

After reading this article, the participant should be able to: Describe the use of stent-assisted angioplasty for intracranial atherosclerotic disease. Recall the present status of stent-assisted managment of intracranial aneurysms. Describe the role of stenting and its technical aspects in the treatment of arteriovenous fistulae and acute stroke.

APA, Harvard, Vancouver, ISO, and other styles

23

Maslarov, D., D. Drenska, and J. Petrova. "Early Cerebrovascular Disease—Clinical Characteristics and Aspects. Description of a Clinical Case." American Journal of Neuroprotection and Neuroregeneration 2, no. 1 (June 1, 2010): 71–77. http://dx.doi.org/10.1166/ajnn.2010.1013.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Berrios, G. E. "Presbyophrenia: Clinical Aspects." British Journal of Psychiatry 147, no. 1 (July 1985): 76–79. http://dx.doi.org/10.1192/bjp.147.1.76.

Full text

Abstract:

SummaryFifteen cases meeting the diagnostic criteria for presbyophrenia are reported and compared with a control sample of patients suffering from dementia. The presbyophrenic patients exhibited more elevated mood, more hyperactivity, more disorientation, and had lower information scores than the controls. Traditional explanations of ‘presbyophrenic behaviour’ such as delirium, pathoplastic effect of personality, or superimposed cerebrovascular disease are not adequate. Instead, presbyophrenia may constitute a sub-type of dementia characterised by severe atrophy of the locus coeruleus, marked impairment of noradrenergic transmission, and uninhibited behaviour.

APA, Harvard, Vancouver, ISO, and other styles

25

Reisberg, Barry, Steven H. Ferris, Thet Oo, and Emile Franssen. "Staging: Relevance for Trial Design in Vascular Burden of the Brain." International Psychogeriatrics 15, S1 (July 2003): 231–39. http://dx.doi.org/10.1017/s1041610203009256.

Full text

Abstract:

Cerebrovascular small vessel disease is now believed to be the major source of vascular burden of the brain. Cerebrovascular small vessel disease and Alzheimer's disease appear to represent pathophysiologic and clinical continua, rather than dichotomous entities. It appears that common etiopathologic mechanisms underlie the clinical presentation of both of these conditions. Therefore, the staging procedures that have been developed for the clinical continuum of age-associated memory impairment, mild cognitive impairment, and the progressive dementia of Alzheimer's disease appear to be applicable for the same continua in cerebrovascular small vessel disease. Although temporal and prognostic aspects have been studied for the Alzheimer's-related portions of this clinical staging continuum, they remain to be elucidated for cerebrovascular small vessel disease.

APA, Harvard, Vancouver, ISO, and other styles

26

Chan, Chee M., and Andrew F. Shorr. "Economic and Outcomes Aspects of Venous Thromboembolic Disease." Critical Care Clinics 28, no. 1 (January 2012): 113–23. http://dx.doi.org/10.1016/j.ccc.2011.09.005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Sockett, Paul. "Social and economic aspects of food-borne disease." Food Policy 18, no. 2 (April 1993): 110–19. http://dx.doi.org/10.1016/0306-9192(93)90019-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Khasanova, D. R., T. V. Danilova, and Z. K. Latypova. "Epilepsy in patients with ischemic brain disease." Kazan medical journal 94, no. 2 (April 15, 2013): 235–39. http://dx.doi.org/10.17816/kmj1595.

Full text

Abstract:

Epilepsy is one of the most actual social problems in modern neurology and psychiatry. According to the results of the domestic and foreign studies, the risk of developing epilepsy increases with age. The increased rate of nervous system vascular and degenerative diseases as well as brain tumors and head injuries in elderly patients is one of the reasons for it. The review is devoted to the development of epilepsy in adults having an active cerebrovascular disease. Epilepsy is the disease with multiple causative factors. Among the etiological factors of epilepsy development in adults, the predominant place belongs to vascular diseases. The article presents the epidemiological aspects of the problem, the questions of pathophysiology, the variability of epileptic syndromes developing as a result of ischemic brain disease. It describes the characteristics of epileptic process as a result of a vascular lesion. The role of the cerebrovascular reactivity in brain vascular diseases development is described. A place of different research methods (such as electroencephalography, transcranial and extracranial duplex ultrasonography scanning of the major brain vessels, different modes of magnetic resonance imaging, functional magnetic resonance imaging and magnetic resonance spectroscopy) in identifying risk factors for seizures in patients with cerebrovascular pathology is reported. Possible exogenous and endogenous precipitants (cerebral atherosclerotic vascular disease, hypertension, cerebrovascular deregulation, increased convulsive predisposition, the external epileptic triggers, etc.) are described.

APA, Harvard, Vancouver, ISO, and other styles

29

RUSHTON, J. "Economic aspects of foot and mouth disease in Bolivia." Revue Scientifique et Technique de l'OIE 27, no. 3 (December 1, 2008): 759–69. http://dx.doi.org/10.20506/rst.27.3.1837.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Bommer, J. "Prevalence and socio-economic aspects of chronic kidney disease." Nephrology Dialysis Transplantation 17, suppl 11 (November 1, 2002): 8–12. http://dx.doi.org/10.1093/ndt/17.suppl_11.8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Puddu, Paolo, Giovanni M. Puddu, Luciana Bastagli, Giorgio Massarelli, and Antonio Muscari. "Coronary and cerebrovascular atherosclerosis: two aspects of the same disease or two different pathologies?" Archives of Gerontology and Geriatrics 20, no. 1 (January 1995): 15–22. http://dx.doi.org/10.1016/0167-4943(94)00600-c.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Ramasubbu, Rajamannar, and Sidney H. Kennedy. "Factors Complicating the Diagnosis of Depression in Cerebrovascular Disease, Part I — Phenomenological and Nosological Issues*." Canadian Journal of Psychiatry 39, no. 10 (December 1994): 596–600. http://dx.doi.org/10.1177/070674379403901003.

Full text

Abstract:

Depression is frequently associated with cerebrovascular disease. Early detection and intervention in depression may enhance rehabilitation potential. Difficulties encountered by clinicians in identifying depression in patients with cerebrovascular disease are numerous. This two part review focuses on issues related to the diagnosis of depression with emphasis on recognition of depressive symptoms and their relevance to the diagnosis of depressive syndromes in the presence of vascular lesions and associated neurological deficits. Furthermore, the value of diagnostic instruments and biological markers in identifying depression following stroke has been critically evaluated. In this first part of this two part paper, phenomenological and nosological aspects are considered with an emphasis on symptom profile, significance of vegetative symptoms and other related emotional responses such as catastrophic reaction, emotionalism and apathy in the diagnosis of depression following stroke. The applicability of diagnostic subcategories to define depressive syndromes associated with cerebrovascular disease and its clinical relevance is also discussed. The authors stress that knowledge on phenomenology of depression and other emotional responses related to cerebrovascular disease will facilitate better understanding of its clinical presentation and may improve diagnostic acumen.

APA, Harvard, Vancouver, ISO, and other styles

33

Gaab, M. R., K. Holl, M. N. Nemati, E. Rzesacz, H. Becker, and H. Dietz. "Mapping of rCBF and cerebrovascular reserve capacity by stable xenon CT in cerebrovascular disease: Pathophysiological aspects and effects of operative therapy." Psychiatry Research 29, no. 3 (September 1989): 309–12. http://dx.doi.org/10.1016/0165-1781(89)90074-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Oliveira, Carolina Camargo de, Sylvia Maria Ciasca, and M. Valeriana L. Moura-Ribeiro. "Stroke in patients with sickle cell disease: clinical and neurological aspects." Arquivos de Neuro-Psiquiatria 66, no. 1 (March 2008): 30–33. http://dx.doi.org/10.1590/s0004-282x2008000100008.

Full text

Abstract:

The aim of this study was to characterize a group of patients (n=8) with sickle cell disease (SCD) and ischemic stroke concerning the clinical, neurological, imaging and progressive aspects. Data were collected from records and completed with an interview of patients and their parents. In this study there were 8 patients with ages ranging from 10 to 23 years old; SCD diagnosis was given between one and two years of age with clinical features of fatigue and anemia. The stroke was ischemic in all individuals and the first cerebrovascular event occurred before 6 years of age; 3 patients had recurrence of stroke despite prophylactic blood transfusion therapy and both cerebral hemispheres were affected in 4 patients. Clinical and neurological current features observed were: acute pain crises, sialorrhea, mouth breathing, motor, and neuropsychological impairments resulting from cortical-subcortical structure lesions.

APA, Harvard, Vancouver, ISO, and other styles

35

Robson, Joanna C., Amit Kiran, Joe Maskell, Andrew Hutchings, Nigel Arden, Bhaskar Dasgupta, William Hamilton, Akan Emin, David Culliford, and Raashid Luqmani. "Which Patients with Giant Cell Arteritis Will Develop Cardiovascular or Cerebrovascular Disease? A Clinical Practice Research Datalink Study." Journal of Rheumatology 43, no. 6 (April 15, 2016): 1085–92. http://dx.doi.org/10.3899/jrheum.151024.

Full text

Abstract:

Objective.To evaluate the risk of cerebrovascular disease and cardiovascular disease (CVD) in patients with giant cell arteritis (GCA), and to identify predictors.Methods.The UK Clinical Practice Research Datalink 1991–2010 was used for a parallel cohort study of 5827 patients with GCA and 37,090 age-, sex-, and location-matched controls. A multivariable competing risk model (non-cerebrovascular/CV-related death as the competing risk) determined the relative risk [subhazard ratio (SHR)] between patients with GCA compared with background controls for cerebrovascular disease, CVD, or either. Each cohort (GCA and controls) was then analyzed individually using the same multivariable model, with age and sex now present, to identify predictors of CVD or cerebrovascular disease.Results.Patients with GCA, compared with controls, had an increased risk SHR (95% CI) of cerebrovascular disease (1.45, 1.31–1.60), CVD (1.49, 1.37–1.62), or either (1.47, 1.37–1.57). In the GCA cohort, predictors of “cerebrovascular disease or CVD” included increasing age, > 80 years versus < 65 years (1.98, 1.62–2.42), male sex (1.20, 1.05–1.38), and socioeconomic status, most deprived quintile versus least deprived (1.34, 1.01–1.78). These predictors were also present within the non-GCA cohort.Conclusion.Patients with GCA are more likely to develop cerebrovascular disease or CVD than age-, sex-, and location-matched controls. In common with the non-GCA cohort, patients who are older, male, and from the most deprived compared with least deprived areas have a higher risk of cerebrovascular disease or CVD. Further work is needed to understand how this risk may be mediated by specific behavioral, social, and economic factors.

APA, Harvard, Vancouver, ISO, and other styles

36

Strickland, Sidney. "Impact of the Coagulation System on the Pathogenesis of Alzheimer's Disease." Blood 130, Suppl_1 (December 7, 2017): SCI—3—SCI—3. http://dx.doi.org/10.1182/blood.v130.suppl_1.sci-3.sci-3.

Full text

Abstract:

Abstract Alzheimer's disease (AD) leads to cognitive impairment and is eventually fatal. The cognitive decline is associated with extensive neuronal degeneration. The most well-known pathological features of AD are extracellular Aβ plaques, intracellular tau tangles, neuroinflammation, and neuronal loss. Less discussed is that AD is often associated with cerebrovascular abnormalities. The symptoms of AD and cerebrovascular pathology could be independent co-morbidities, with both being increased in aging populations. However, it is also possible that there is a mechanistic link between AD and vascular pathology. The interaction of Aβ with fibrin(ogen) can lead to increased fibrin deposition in cerebral blood vessels, and these accumulated fibrin deposits may disrupt cerebral blood flow and induce microinfarcts, inflammation, and BBB damage, all of which are aspects of cerebrovascular dysfunction observed in AD. At the same time, Ab's ability to activate FXII may contribute to increased fibrin generation through the intrinsic coagulation pathway as well as to increased inflammation and vascular permeability through bradykinin release from HK. These possible roles of Aβ in thrombosis, fibrinolysis, and inflammation via its interaction with fibrinogen and FXII, summarized in Figure 1, will be discussed. Disclosures No relevant conflicts of interest to declare.

APA, Harvard, Vancouver, ISO, and other styles

37

Harbaugh, Robert E., and Akash Agarwal. "Training Residents in Endovascular Neurosurgery." Neurosurgery 59, suppl_5 (November 1, 2006): S3–277—S3–281. http://dx.doi.org/10.1227/01.neu.0000237355.55265.03.

Full text

Abstract:

Abstract NEUROSURGEONS HAVE A long history of treating cerebrovascular disease. Understanding the vascular anatomy and physiology of the nervous system and management of patients with abnormalities of theses vascular structures are vitally important aspects of neurosurgery resident training. Over the past decade, the treatment of cerebrovascular disease has been evolving toward endovascular strategies for many patients. Interventional neuroradiologists were the pioneers in developing this area of therapy, but the number of neurosurgical trainees in neuroendovascular treatment is increasing, and other specialties, including neurology, vascular surgery, and cardiology, are now entering the field of neuroendovascular treatment. The purpose of this article is to review the current credentialing guidelines for neurosurgeons to use endovascular techniques in the treatment of cerebrovascular disease and to consider options for resident training in the rapidly evolving field of endovascular neurosurgery.

APA, Harvard, Vancouver, ISO, and other styles

38

Di Napoli, Mario, and Imtiaz M. Shah. "Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective." Journal of Aging Research 2011 (2011): 1–18. http://dx.doi.org/10.4061/2011/857484.

Full text

Abstract:

The incidence of cerebrovascular disease is highest in the elderly population. However, the pathophysiological mechanisms of brain response to cerebral ischemia in old age are currently poorly understood. Ischemic changes in the commonly used young animal stroke models do not reflect the molecular changes associated with the aged brain. Neuroinflammation and oxidative stress are important pathogenic processes occurring during the acute phase of cerebral ischemia. Free radical generation is also implicated in the aging process, and the combination of these effects in elderly stroke patients could explain the higher risk of morbidity and mortality. A better understanding of stroke pathophysiology in the elderly patient would assist in the development of new therapeutic strategies for this vulnerable age group. With the increasing use of reperfusion therapies, inflammatory pathways and oxidative stress remain attractive therapeutic targets for the development of adjuvant neuroprotective agents. This paper will discuss these molecular aspects of acute stroke and senescence from a bench-to-bedside research perspective.

APA, Harvard, Vancouver, ISO, and other styles

39

Creese, Andrew L. "Economic aspects of tropical disease: What is better health worth?" Transactions of the Royal Society of Tropical Medicine and Hygiene 79, no. 2 (January 1985): 143–48. http://dx.doi.org/10.1016/0035-9203(85)90317-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Rossi, A., R. Biancheri, E. Lanino, M. Faraci, R. Haupt, C. Micalizzi, and P. Tortori-Donati. "Neuroradiology of Pediatric Hemolymphoproliferative Disease." Rivista di Neuroradiologia 16, no. 2 (April 2003): 221–50. http://dx.doi.org/10.1177/197140090301600203.

Full text

Abstract:

Hemolymphoproliferative diseases (HLD) are among the most common causes of morbidity and mortality in children. In the past few years, the increased effectiveness of treatment modalities has significantly increased overall survival, but has also disclosed new aspects of the natural history of these disorders, among which central nervous system (CNS) involvement. CNS complications of HLD can basically be categorized into direct localization of primary disease, indirect effects of malignancy such as cerebrovascular or infectious complications, and iatrogenic side effects. Magnetic resonance imaging plays an important, often crucial role in the diagnosis of several of these disorders. Close interdisciplinary collaboration between hemato-oncologists and neuroradiologists is of paramount importance to provide affected children with an early diagnosis and proper treatment.

APA, Harvard, Vancouver, ISO, and other styles

41

Malgor, Rafael D., Emily A. Wood, Otavio A. Iavarone, and Nicos Labropoulos. "Stratifying risk: asymptomatic carotid disease." Jornal Vascular Brasileiro 11, no. 1 (March 2012): 43–52. http://dx.doi.org/10.1590/s1677-54492012000100008.

Full text

Abstract:

Stroke generates significant healthcare expenses and it is also a social and economic burden. The carotid artery atherosclerotic plaque instability is responsible for a third of all embolic strokes. The degree of stenosis has been deliberately used to justify carotid artery interventions in thousands of patients worldwide. However, the annual risk of stroke in asymptomatic carotid artery disease is low. Plaque morphology and its kinetics have gained ground to explain cerebrovascular and retinal embolic events. This review provides the readers with an insightful and critical analysis of the risk stratification of asymptomatic carotid artery disease in order to assist in selecting potential candidates for a carotid intervention.

APA, Harvard, Vancouver, ISO, and other styles

42

Gertsev, V. N., A. N. Stoyanov, S. S. Mashchenko, and S. A. Antonenko. "New pathogenetic aspects of the relationship between some risk factors of cerebrovascular diseases and Parkinson’s disease." INTERNATIONAL NEUROLOGICAL JOURNAL, no. 7.109 (November 20, 2019): 37–42. http://dx.doi.org/10.22141/2224-0713.7.109.2019.183011.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Slabkiy, G. О., and М. М. Prokopiv. "The results of the risk factors study for the development of cerebrovascular diseases in women in Kyiv city." HEALTH OF WOMAN, no. 5-6(151-152) (July 30, 2020): 54–57. http://dx.doi.org/10.15574/hw.2020.151-152.54.

Full text

Abstract:

Cerebrovascular diseases in the leading countries of the world occupy the second place among all the causes of death and become the main cause of disability of the population in working age. Preventive measures for the development of cerebrovascular disease are directed at eliminating or reducing the impact of risk factors of disease. The objective: to define risk factors for the development of cerebrovascular disease in women under the age of 40 years residing in Kyiv. Materials and methods. 420 women under the age of 40 years residing in Kyiv were questioned with the use of sociological method. A universal adapted questionnaire was used to conduct the research. The results were processed with the application of statistical method and the method of structural-and-logical analysis. Results. It has been defined that up to 32.0% of women have risk factors for developing cerebrovascular diseases of medical nature, up to 69.0% – of hereditary nature, up to 69.0% – of those associated with lifestyle and 32.0% – of socio-economic nature. Among women who did not have a diagnosis of cerebrovascular disease 24.6±2.2% of the polled have hypertensive disease. At the same time, 21.9±2.1% of them do not follow the doctor’s recommendations on healthy lifestyle and 13.8±1.7% of them do not follow the recommendations of the doctor on taking medications. Among women who have been diagnosed with cerebrovascular disease 31.7±2.3% of the polled have hypertensive disease. At the same time, 48.7±2.5% of them do not follow the doctor’s recommendations on healthy lifestyle and 38.5±2.4% do not follow the recommendations of the doctor regarding the intake of medicines. All that leads to high risks of developing a cerebral stroke. Conclusions. A high level of risk factors for cerebrovascular disease was defined among women aged up to 40 years of life residing in Kyiv that requires the introduction of comprehensive information and sanitary preventive programs. Keywords: Kyiv, women, cerebrovascular diseases, risk factors.

APA, Harvard, Vancouver, ISO, and other styles

44

Mohelska, Hana, and Petra Maresova. "Economic and Managerial Aspects of Alzheimer's Disease in The Czech Republic." Procedia Economics and Finance 23 (2015): 521–24. http://dx.doi.org/10.1016/s2212-5671(15)00343-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Paisley, Larry G. "Economic Aspects of Disease Monitoring with Special Reference to Bovine Paratuberculosis." Acta Veterinaria Scandinavica 42, Suppl 1 (2001): S17. http://dx.doi.org/10.1186/1751-0147-42-s1-s17.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Grosse, Gerrit M., Edzard Schwedhelm, Hans Worthmann, and Chi-un Choe. "Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications." International Journal of Molecular Sciences 21, no. 5 (March 5, 2020): 1798. http://dx.doi.org/10.3390/ijms21051798.

Full text

Abstract:

The amino acid L-arginine serves as substrate for the nitric oxide synthase which is crucial in vascular function and disease. Derivatives of arginine, such as asymmetric (ADMA) and symmetric dimethylarginine (SDMA), are regarded as markers of endothelial dysfunction and have been implicated in vascular disorders. While there is a variety of studies consolidating ADMA as biomarker of cerebrovascular risk, morbidity and mortality, SDMA is currently emerging as an interesting metabolite with distinct characteristics in ischemic stroke. In contrast to dimethylarginines, homoarginine is inversely associated with adverse events and mortality in cerebrovascular diseases and might constitute a modifiable protective risk factor. This review aims to provide an overview of the current evidence for the pathophysiological role of arginine derivatives in cerebrovascular ischemic diseases. We discuss the complex mechanisms of arginine metabolism in health and disease and its potential clinical implications in diverse aspects of ischemic stroke.

APA, Harvard, Vancouver, ISO, and other styles

47

Tsilimigras, Diamantis I., Demetrios Moris, Georgios Karaolanis, Stavros K. Kakkos, Konstantinos Filis, and Fragiska Sigala. "Rivaroxaban versus Clopidogrel for Peripheral Artery Disease: A Clinico-Economic Approach of the COMPASS Trial." Current Pharmaceutical Design 24, no. 38 (February 27, 2019): 4516–17. http://dx.doi.org/10.2174/1381612825666190101100832.

Full text

Abstract:

Peripheral artery disease (PAD) is the third most common manifestation of atherosclerosis after coronary artery (CAD) and cerebrovascular disease (CVD). People with PAD have plaque findings in other vascular territories as well and, thus, are at increased risk of major adverse cardiovascular or cerebrovascular events (MACCE), including myocardial infarction, and stroke. In that context, the COMPASS multicenter, randomized controlled trial showed that the risk of MACCE was significantly reduced by 24% in the rivaroxaban plus aspirin arm compared with aspirin alone (4.1% vs 5.4% respectively; HR: 0.76, 95% CI: 0.66 to 0.86). Interestingly, the rivaroxaban/aspirin arm also showed a reduction in cardiovascular death (HR: 0.78; 95% CI: 0.64-0.96]) and allcause mortality (HR: 0.82; 95% CI: 0.71-0.96) by 22% and 18%, respectively. Recently, the FDA approved the use of the dual pathway approach, rivaroxaban 2.5 mg twice daily plus aspirin 75-100mg once daily, to reduce the risk of major cardiovascular (CV) events, such as CV death, myocardial infarction and stroke, in people with CAD as well as PAD. In comparing rivaroxaban plus aspirin versus aspirin alone, a preliminary economic analysis showed that saving per patient was USD 462 for events and USD 220 for procedures with a total reduction of USD 682 per participant in the US with the combination group (rivaroxaban plus aspirin). The data from COMPASS trial suggest that low dose rivaroxaban plus aspirin may be a preferred treatment strategy in PAD patients in whom the bleeding risk is deemed to be favourable.

APA, Harvard, Vancouver, ISO, and other styles

48

Levine, SR, and RL Brey. "Neurological Aspects of Antiphospholipid Antibody Syndrome." Lupus 5, no. 5 (October 1996): 347–53. http://dx.doi.org/10.1177/096120339600500503.

Full text

Abstract:

Antiphospholipid antibodies (aPL) have been associated with a variety of neurological disorders, mostly linked to focal neuroparenchymal ischemia or infarction. Cerebral ischemia associated with the antiphospholipid syndrome (APS) occurs at a younger age than typical atherothrombotic cerebrovascular disease, is often recurrent, and high positive GPL values are usually linked to the presence of a lupus anticoagulant. When other features of the syndrome are not present and cerebral ischemia occurs only associated with anticardiolipin immunoreactivity, there appears to be no discerning features of these patients unless GPL > 40 for which recurrent thrombo-occlusive events appear to occur more frequently. Other neurological manifestations associated with aPL include cerebral venous sinus thrombosis, ocular ischemia, dementia, including ischemic encephalopathy, and chorea. The role of aPL in migrainous events is controversial and may not play a role in recent, large case-controlled studies. Most seizures in patients harboring aPL are associated with focal brain infarction.

APA, Harvard, Vancouver, ISO, and other styles

49

Dvornichenko, G. B., A. B. Yaschenko, S. V. Grynjuk, P. S. Bazovkin, and T. D. Matviychuk. "Epidemiological aspects of cerebrovascular diseases in miners with vibration disease due to action of the general vibration." Ukrainian Journal of Occupational Health 2014, no. 2 (June 30, 2014): 6–12. http://dx.doi.org/10.33573/ujoh2014.02.006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Kopchak, Oksana O., Natalia Yu Bachinskaya, and Oleksandr R. Pulyk. "VASCULAR RISK FACTORS AND COGNITIVE FUNCTIONS IN THE PATIENTS WITH CEREBROVASCULAR DISEASE." Wiadomości Lekarskie 73, no. 10 (2020): 2250–54. http://dx.doi.org/10.36740/wlek202010128.

Full text

Abstract:

The aim: To assess the severity of cognitive impairment (CI) in patients with cerebrovascular disease (CVD) depending on the number of vascular risk factors (VRF). Materials and methods: The study consisted of five hundred and eighty patients with CVD (247 females and 333 males) aged from 45 to 89 years (mean age: 64,1±8,9 years). The patients were divided into 6 groups (I, II, III, IV, V, VI) depending on the number of VRF. The examination consisted of a standard clinical evaluation, neurological examination, the application of neuropsychological tests (the MMSE; the PALT/The Paired Associates Learning Test; clock drawing test), laboratory tests, MRI of brain. Results: According to ANOVA, the greater the number of VRF the patients had, the lower was their total MMSE score corresponding to more pronounced cognitive decline (F=2,97, p=0,012). A significant negative correlation between patients’ age and their MMSE score was detected regardless of their VRF count. The patients of the V and VI groups had substantially lower parameters of immediate, delayed memory and clock drawing test score comparing to the patients of the I group. Conclusions: The presence of 4 and more VRF was related to more pronounced CI in the patients with CVD. Decline of different aspects of memory, attention, spatial orientation, abstract thinking, planning, concentration, executive and visuospatial skills in groups of patients with 4,5 and 6 vascular risk factors was established. Age was substantially associated with cognitive decline in all the group of patients.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!