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Dissertations / Theses on the topic 'ED attentional set shifting'

Author: Grafiati

Published: 10 December 2022

Last updated: 31 July 2025

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1

Wang, Jiachao. "Bayesian analysis for quantification of individual rat and human behavioural patterns during attentional set-shifting tasks." Thesis, University of St Andrews, 2018. http://hdl.handle.net/10023/14843.

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Attentional set-shifting tasks, consisting of multiple stages of discrimination learning, have been widely used in animals and humans to investigate behavioural flexibility. However, there are several learning criteria (e.g., 6-correct-choice-in-a-row, or 10-out- of-12-correct) by which a subject might be judged to have learned a discrimination. Furthermore, the currently frequentist approach does not provide a detailed analysis of individual performance. In this PhD study, a large set of archival data of rats performing a 7-stage intra-dimensional/extra-dimensional (ID/ED) attentional set- sh

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2

Pershing, Michelle. "Acute elevations in kynurenic acid result in cognitive inflexibility in an attentinal set-shfiting task via an alpha 7-mediated mechanism." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354032404.

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3

Stanislaus-Carter, Rudi. "Behavioural examination of the role of the thalamic reticular nucleus in attention." Thesis, University of St Andrews, 2017. http://hdl.handle.net/10023/16298.

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The ability to selectively attend to aspects of the environment which signal opportunity or danger, while marginalising irrelevant stimuli is critical to an animal's survival. With finite cognitive resources, the brain must dedicate resources to only those stimuli that are biologically significant. Incoming thalamic information must therefore be filtered. The thalamic reticular nucleus has long been considered critically involved in modulating thalamic sensory processing. Sharing connections with both the thalamus and cortex, it is ideally located to modulate the transfer of pertinent incoming

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4

Crofts, Harriet Sarah. "Methodology for the repeated assessment of cognitive and physiological parameters within a home cage environment in the common marmoset (Callithrix jacchus) : assessment of repeated attentional set shifting and the sleep electroencephalogram." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299537.

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5

Foister, Nicola. "Behavioural phenotyping of mice with genetic alterations of the GABA[subscript A] receptor." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/988.

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GABA is the main inhibitory neurotransmitter of the central nervous system. GABA[subscript A]Rs are multimeric transmembrane receptors, which are composed of 5 subunits. It is known that there are 19 subunits that can make up the GABA[subscript A]Rs, allowing for a vast array of receptor subtypes. In addition to the GABA binding site GABA[subscript A]Rs have distinct allosteric binding sites for benzodiazepines, barbiturates, ethanol, certain general anaesthetics and neuroactive steroids. The molecular heterogeneity of the GABA[subscript A]R is accompanied by distinct pharmacological profiles

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6

Phenis, David Anthony. "Performance of Adult Rats Exposed to Elevated Levels of Kynurenic Acid during Gestation in a Rodent Target Detection Task: A Translational Model for Studying the Effects of Cognitive Training." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu154211727456543.

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7

Miguel, Patrícia Maidana. "Hipóxia-isquemia neonatal e o desenvolvimento de características relacionadas ao transtorno de déficit de atenção/hiperatividade em ratos wistar machos : análises comportamentais e dano tecidual cerebral." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/134839.

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A hipóxia-isquemia (HI) encefálica neonatal pode gerar sequelas neurológicas permanentes nos indivíduos que sobrevivem a este evento precoce. Dentre estas sequelas, o diagnóstico de Transtorno de déficit de atenção e hiperatividade (TDAH) já foi relacionado em pesquisa clínica. Sabendo que não há consenso de um modelo adequado para o estudo do TDAH em pesquisa experimental, novas abordagens que contribuam para o desenvolvimento desse modelo são necessárias. Assim, o objetivo do presente estudo foi investigar se a HI neonatal contribui para o desenvolvimento das características comportamentais

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8

García, Aguirre Ana I. "An evaluation of cognitive deficits in a rat-model of Huntington's disease." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/8827.

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The purpose of this thesis was to develop methodology by which treatments for the cognitive impairments in Huntington's disease (HD) could be tested. As such, the thesis focused mainly on evaluating rats with quinolinic acid (QA) lesions of the striatum, as this manipulation mimics some aspects of the neural damage in Huntington's disease, to try to identify cognitive deficits of HD resulting from cell loss in the striatum. In the first part (Chapters 3-5), the role of the striatum in implicit memory was investigated. Chapter 3 compared the performance of rats and humans on a reaction time tas

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9

Jeng, Ren-Tang, and 鄭任唐. "Attentional Set-shifting in Spontaneously Hypertensive Rats." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/13284139201871439196.

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碩士<br>國立中正大學<br>心理學研究所<br>99<br>Attention-deficit/hyperactivity disorder (ADHD), a common psychiatric disorder occurring in childhood and adolescence, is characterized by inattention, hyperactivity, and impulsivity. The spontaneously hypertensive rat (SHR) is a widely used animal model for ADHD research. A number of studies suggest that the prefrontal cortex dysfunctions can impair the inhibition system of ADHD patients, resulting in their impulsive behaviors. In human studies, the attentional set-shifting task (ASST) is frequently used to study the inhibition system, and its influences on att

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10

Ou, Hui-Shan, and 歐惠姍. "Deficit in attentional set shifting of MPTP-induced Parkinson's disease rat model." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/st9v8k.

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碩士<br>國立中正大學<br>心理學系研究所<br>105<br>Parkinson’s disease (PD) is a neurodegenerative disorder. In addition to the typical motor symptoms, some patients display cognitive deficits in the mid or later phases of the disease. To study the pathology and physiology of the disease, the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- lesioned rat has been widely used as an animal model. However, behavioral flexibility of MPTP-lesioned rats has not been thoroughly studied yet. Furthermore, previous studies on PD have been focused mostly on the dopaminergic innervation on the classic cortex-basal gan

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11

Millie, Lauren A. "An automated attentional set-shifting task in HAP, LAP, and alcohol-exposed cHAP mice." Thesis, 2018. https://doi.org/10.7912/C2NH28.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Alcoholics often experience difficulties ceasing drinking, potentially related to excessive behavioral inflexibility that either precedes or results from high alcohol consumption. Components of the Wisconsin Card-Sorting Task (WCST) a type of Attentional Set-Shifting (AttSS) task measuring impairments in behavioral flexibility have been modified to measure similar constructs within animals. Previous work has shown impaired AttSS in abstinent alcoholics and nonalcoholic individuals with a family history of alcoholism, as well as in mi

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12

McLean, Samantha L., Ben Grayson, M. Harris, et al. "Isolation rearing impairs novel object recognition and attentional set shifting performance in female rats." 2008. http://hdl.handle.net/10454/8486.

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Yes<br>It has been suggested that the isolation rearing paradigm models certain aspects of schizophrenia symptomatology. This study aimed to investigate whether isolation rearing impairs rats’ performance in two models of cognition: the novel object recognition (NOR) and attentional set-shifting tasks, tests of episodic memory and executive function, respectively. Two cohorts of female Hooded-Lister rats were used in these experiments. Animals were housed in social isolation or in groups of five from weaning, post-natal day 28. The first cohort was tested in the NOR test with inter-tri

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13

McLean, Samantha L., J. P. Beck, M. L. Woolley, and Joanna C. Neill. "A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats." 2007. http://hdl.handle.net/10454/8487.

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Yes<br>Rationale The NMDA receptor antagonist, phencyclidine (PCP), has been shown to induce symptoms characteristic of schizophrenia. A loss in executive function and the ability to shift attention between stimulus dimensions is impaired in schizophrenia; this can be assessed in rodents by the perceptual attentional set-shifting task. Objective The aim of this study was to investigate whether the deficits induced by sub-chronic PCP in attentional set-shifting could be reversed by sub-chronic administration of clozapine, risperidone or haloperidol. Methods Adult female hooded-Li

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14

Millie, Lauren A. "Examining Simultaneous Alcohol and ∆9-Tetrahydrocannabinol Self-Administration on Behavioral Flexibility and Dorsal Striatal CB1 Expression in cHAP Mice." Thesis, 2020. http://hdl.handle.net/1805/23134.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Although marijuana and alcohol are two of the most commonly used drugs in the United States, relatively little is understood about how these drugs interact to effect drug use, cognitive behaviors, and neurophysiological changes. Specific drug use patterns such as simultaneous use may produce differential effects for consumption and other behaviors in addition to unique neurobiological changes compared to singular drug use. In order to better understand the effects of simultaneous alcohol and marijuana (SAM) use, we used the selective

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15

McLean, Samantha L., Nagi F. Idris, Ben Grayson та ін. "PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidineinduced cognitive deficit in the attentional set-shifting task in female rats". 2011. http://hdl.handle.net/10454/8463.

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y<br>The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister rats received sub-chronic phencyclidine (PCP) (2mg/kg) or vehicle i.p. twice daily for 7 days, followed by 7 days’ washout. PCP-treated rats then received PNU-120596 (10mg/kg; s.c.) or saline and were tested in the attentional set-shifting task. Sub-chronic PCP produced a significant cognitive deficit in the extra-dimensional shift (EDS) phase of the task (p < 0.001, compared with vehicle). PNU-120596 significantly improved performan

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16

Huang, Jian-Yuan, and 黃建源. "Blockage of dopamine D2 receptor in orbitofrontal cortex fails to abolish the performance improving effects of atomoxetine on the spontaneusly hypertensive rat in an attentional set-shifting task." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/28686950979553036922.

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碩士<br>國立中正大學<br>心理學研究所<br>101<br>Attention-deficit hyperactivity disorder (ADHD) is a clinically heterogeneous disorder. The symptoms include inattention, hyperactivity and impulsivity. Atomoxetine (ATX) is a selective norepinephrine reuptake inhibitor which served as a non-psychostimulant drug for the treatment for ADHD. Previous studies found that ATX increases not only norepinephrine levels but also dopamine levels in prefrontal cortex. The effect of ATX on the dopamine system is similar to methylphenidate, the first-line treatment for ADHD. However, the neural mechanism of ATX treatment of

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17

(9008666), Lauren Millie. "EXAMINING SIMULTANEOUS ALCOHOL AND ∆9-TETRAHYDROCANNABINOL SELF-ADMINISTRATION ON BEHAVIORAL FLEXIBILITY AND DORSAL STRIATAL CB1 EXPRESSION IN CHAP MICE." Thesis, 2020.

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<div><div><div><p>Although marijuana and alcohol are two of the most commonly used drugs in the United States, relatively little is understood about how these drugs interact to effect drug use, cognitive behaviors, and neurophysiological changes. Specific drug use patterns such as simultaneous use may produce differential effects for consumption and other behaviors in addition to unique neurobiological changes compared to singular drug use. In order to better understand the effects of simultaneous alcohol and marijuana (SAM) use, we used the selectively bred crossed High Alcohol Preferring mic

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