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Journal articles on the topic 'EDCs impact'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Singh, Desh Deepak. "Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary Intake." Journal of Xenobiotics 15, no. 1 (2024): 1. https://doi.org/10.3390/jox15010001.

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Addressing the consequences of exposure to endocrine-disrupting chemicals (EDCs) demands thorough research and elucidation of the mechanism by which EDCs negatively impact women and lead to breast cancer (BC). Endocrine disruptors can affect major pathways through various means, including histone modifications, the erroneous expression of microRNA (miRNA), DNA methylation, and epigenetic modifications. However, it is still uncertain if the epigenetic modifications triggered by EDCs can help predict negative outcomes. Consequently, it is important to understand how different endocrine disrupter

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2

Park, SoMi, and ChaeWeon Chung. "How do mothers with young children perceive endocrine-disrupting chemicals?: an exploratory qualitative study." Korean Journal of Women Health Nursing 29, no. 4 (2023): 337–47. http://dx.doi.org/10.4069/kjwhn.2023.11.28.

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Purpose: Despite the health impacts of endocrine-disrupting chemicals (EDCs) beginning in the early stages of life, there is little research on the perception of EDCs among Korean mothers, who are primarily responsible for protecting children. This study aimed to explore how mothers with young children perceived EDCs for their concerns, the issues they faced, and the way they dealt with them.Methods: An exploratory qualitative design was utilized. Twelve mothers who were recruited from snowball sampling participated in voluntary interviews. Individual in-depth interviews lasting approximately

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Ghosh, Abhinandan, Adrija Tripathy, and Debidas Ghosh. "Impact of Endocrine Disrupting Chemicals (EDCs) on Reproductive Health of Human." Proceedings of the Zoological Society 75, no. 1 (2022): 16–30. http://dx.doi.org/10.1007/s12595-021-00412-3.

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AbstractAt present, endocrine disrupting chemicals (EDCs) have gained attention in human pathophysiology, and many studies have yet been conducted to explain the mechanism of these chemical compounds on endocrine and reproductive dysfunctions. In human the maximum studies focus towards the exposure to endocrine disrupting chemicals and their disorders on different endocrine axises though sufficient information are not available on reproductive systems in human. A huge number of EDCs resulting the interference of the normal functions of hypothalamic-pituitary–gonadal axis. There are several typ

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P, Nivedha. "The Impact of Environmental Endocrine Disruptors on Mammalian Endocrine Systems and Hormonal Changes." Technoarete Transactions on Recent Research in Applied Microbiology and Biotechnology 1, no. 1 (2022): 16–20. http://dx.doi.org/10.36647/ttrramb/01.01.a004.

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This study discusses the impact of the EDCS or environmental endocrine disruptors in the mammalian endocrine system and also in the hormonal changes. As the EDCs have a role to mimic the pathway and the activity of hormones then the detection method is the first and foremost important concern in this scenario. This study also reflects some detection assays of environmental endocrine disruptors by which their impact can be effectively understood. As EDCs alter the hormonal function then it can be said that beta lactamase activity is the main theme for detecting endocrine disruptors. Endocrine d

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Rodrigues, Vinicius Gonçalves, Guilherme Henrique, Érica Kássia Sousa-Vidal, et al. "Thyroid under Attack: The Adverse Impact of Plasticizers, Pesticides, and PFASs on Thyroid Function." Endocrines 5, no. 3 (2024): 430–53. http://dx.doi.org/10.3390/endocrines5030032.

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Endocrine-disrupting chemicals (EDCs) are synthetic or natural compounds that interfere with the endocrine system, inducing harmful effects on organisms depending on the dose and period of exposure. Numerous studies have identified concerning amounts of EDCs in environmental and human samples. The thyroid gland is essential for thyroid hormone production and controls several body functions. Several EDCs have been classified as thyroid disruptors, impairing thyroid hormone production, synthesis, metabolism, transport, and/or actions. Notably, thyroid disorders are the second most prevalent endo

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6

Bhattacharjee, Nandini, Susmita Sarkar, and Biplab Giri. "Impact of endocrine disrupting chemicals (EDCs) on the predisposition of cancer and polycystic ovary syndrome (PCOS): A Note." Journal of Drug Delivery and Therapeutics 12, no. 5 (2022): 3–7. http://dx.doi.org/10.22270/jddt.v12i5.5582.

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Endocrine Disrupting Chemicals (EDCs) or Endocrine Disruptors are unique assemblage or cluster of emerging pollutants as they affect the synthesis, release and transport of hormones. EDCs have been associated with a diverse array of health issues and diseases. EDCs can alter the endocrine system and are involved in carcinogenesis and inducing poly-cystic ovary syndrome (PCOS). The objective of this article is to furnish an outline of research on environmental aspects of EDCs and their effects on human health specially on cancer and PCOS based on evidence from animal and human studies. EDCs inc

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Gálvez-Ontiveros, Yolanda, Sara Páez, Celia Monteagudo, and Ana Rivas. "Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases." Nutrients 12, no. 4 (2020): 1158. http://dx.doi.org/10.3390/nu12041158.

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Endocrine disruptors (EDCs) have been associated with the increased incidence of metabolic disorders. In this work, we conducted a systematic review of the literature in order to identify the current knowledge of the interactions between EDCs in food, the gut microbiota, and metabolic disorders in order to shed light on this complex triad. Exposure to EDCs induces a series of changes including microbial dysbiosis and the induction of xenobiotic pathways and associated genes, enzymes, and metabolites involved in EDC metabolism. The products and by-products released following the microbial metab

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Farr, Brian D., Cynthia M. Otto, and Julia E. Szymczak. "Expert Perspectives on the Performance of Explosive Detection Canines: Operational Requirements." Animals 11, no. 7 (2021): 1976. http://dx.doi.org/10.3390/ani11071976.

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Explosive detection canines (EDC) play an important role in protecting people and property. The utilization of and research on EDCs is often based on personal experience or incomplete knowledge. EDC practitioners (handlers, trainers, and leaders) possess the institutional knowledge necessary to understand EDC operational requirements. This study utilized a qualitative approach with semi-structured interviews of EDC experts (n = 17) from across the employment spectrum. The interviews elicited EDC expert perceptions of the performance of the EDC team and the operational requirements in the physi

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9

Yang, Yinke, Jiang-Yong Min, Jamal S. Rana, et al. "VEGF enhances functional improvement of postinfarcted hearts by transplantation of ESC-differentiated cells." Journal of Applied Physiology 93, no. 3 (2002): 1140–51. http://dx.doi.org/10.1152/japplphysiol.00307.2002.

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Despite considerable advances in medicine, the incidence of heart failure remains high in patients after myocardial infarction (MI). This study investigated the effects of engrafted early-differentiated cells (EDCs) from mouse embryonic stem cells, with or without transfection of vascular endothelial growth factor (VEGF) cDNA (phVEGF165), on cardiac function in postinfarcted mice. EDCs were transfected with green fluorescent protein (GFP) cDNA and transplanted into infarcted myocardium. Compared with the MI mice receiving cell-free medium, cardiac function was significantly improved in the MI

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10

Ganesh, Harrish, James Moran, Saptarshi Roy, et al. "Impact of Persistent Endocrine-Disrupting Chemicals on Human Nuclear Receptors: Insights from In Silico and Experimental Characterization." International Journal of Molecular Sciences 26, no. 7 (2025): 2879. https://doi.org/10.3390/ijms26072879.

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Endocrine-disrupting chemicals (EDCs) are notable for their persistence, bioaccumulation, and associations with cancer. Human nuclear receptors (hNRs) are primary targets disrupted by these persistent EDCs, resulting in alterations to xenobiotic metabolism, lipid homeostasis, and endocrine function, which can lead to carcinogenic effects. Despite their hazardous effects, comprehensive studies on EDC interactions and their impacts on hNRs remain limited. Here, we profiled the interactions of persistent EDCs, including PFAS, plastic additives, bisphenols, polybrominated diphenyl ethers, and phth

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Pocar, Paola, Valeria Grieco, Lucia Aidos, and Vitaliano Borromeo. "Endocrine-Disrupting Chemicals and Their Effects in Pet Dogs and Cats: An Overview." Animals 13, no. 3 (2023): 378. http://dx.doi.org/10.3390/ani13030378.

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Over the past few decades, several pollutants classified as environmental endocrine-disrupting chemicals (EDCs) have become a matter of significant public health concern. Companion animals play a major role in human society, and pet ownership is substantially increasing worldwide. These intimate human–pet relationships imply sharing much of the same environment, thus including exposure to similar levels of EDCs in daily routine. Here, we review the current knowledge on the sources and routes of exposure to EDCs in domestic indoor and outdoor environments and discuss whether endocrine disruptio

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Kadhim, Sajjad Jawad, Mohsin Abbas Sahib, Salam Mohammed Khlaif, Mustafa Kareem AL-Azzawi, and Nabaa Abbas Zubaidi. "EVALUATING THE IMPACT OF ENDOCRINE-DISRUPTING CHEMICALS ON FERTILITY IN WILDLIFE: FROM AMPHIBIANS TO MAMMALS." European Journal of Medical Genetics and Clinical Biology 1, no. 8 (2024): 216–28. https://doi.org/10.61796/jmgcb.v1i8.841.

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Endocrine-disrupting chemicals are contaminants that interrelate with wildlife's endocrine systems, producing negative influences on reproductive health and growth. Industrial pollutants, medicines and pesticides are between the chemicals that have develop a main source of worry due to of their pervasiveness in the environment and capability to reason ecological damage. This study brings both present data on the effects of EDCs on reproductive health in a diversity of animal species, particularly birds, fish, frogs, and mammals. Amphibians, together their complex life cycles and pored skin are

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Hampl, Richard, Jana Kubátová, Vladimír Sobotka, and Jiří Heráček. "Steroids in semen, their role in spermatogenesis, and the possible impact of endocrine disruptors." Hormone Molecular Biology and Clinical Investigation 13, no. 1 (2013): 1–5. http://dx.doi.org/10.1515/hmbci-2013-0003.

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AbstractThe data on hormonal steroids in the human seminal plasma and their role in spermatogenesis are summarized. The seminal steroid levels need not correlate with the blood plasma levels. The recent reports showed that androgen, especially dihydrotestosterone, and the estrogen levels in the seminal fluid may be used as the markers of spermatogenesis impairment. The estradiol concentration in the seminal plasma was higher than in the blood plasma, and its levels were significantly increased in men with impaired spermatogenesis. A good indicator for predicting the normal spermatogenesis, the

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14

Balabanič, Damjan, Marjan Rupnik, and Aleksandra Krivograd Klemenčič. "Negative impact of endocrine-disrupting compounds on human reproductive health." Reproduction, Fertility and Development 23, no. 3 (2011): 403. http://dx.doi.org/10.1071/rd09300.

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There is increasing concern about chemical pollutants that are able to mimic hormones, the so-called endocrine-disrupting compounds (EDCs), because of their structural similarity to endogenous hormones, their ability to interact with hormone transport proteins or because of their potential to disrupt hormone metabolic pathways. Thus, the effects of endogenous hormones can be mimicked or, in some cases, completely blocked. A substantial number of environmental pollutants, such as polychlorinated biphenyls, dioxins, polycyclic aromatic hydrocarbons, phthalates, bisphenol A, pesticides, alkylphen

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15

Chen, Mei, Klas Ohman, Chris Metcalfe, Michael G. Ikonomou, Prasanna L. Amatya, and Jeffrey Wilson. "Pharmaceuticals and Endocrine Disruptors in Wastewater Treatment Effluents and in the Water Supply System of Calgary, Alberta, Canada." Water Quality Research Journal 41, no. 4 (2006): 351–64. http://dx.doi.org/10.2166/wqrj.2006.039.

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Abstract Due to a growing interest in the occurrence of pharmaceutically active compounds (PhACs) and endocrine disrupting compounds (EDCs) in the aquatic environment and their potential impacts on humans and the environment, a collaborative study was conducted on these emerging contaminants in the effluents from the wastewater treatment plants (WWTPs) and in the drinking water supply system of Calgary, Alberta. A number of PhACs and EDCs were detected in the WWTP effluents, at concentrations ranging from ng/L to low µ-g/L. Although these compounds were generally removed from WWTP effluents du

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Lakra, Anu Bela, Suryapratap Ray, and Tejasvi Bhatia. "Impact of Endocrine Disrupting Chemicals on Human Reproductive System: A Toxicological Perspective." Nature Environment and Pollution Technology 21, no. 1 (2022): 149–57. http://dx.doi.org/10.46488/nept.2022.v21i01.016.

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Recent clinical or epidemiological studies are reporting alarming results on the effects of certain groups of chemicals on the female reproductive system. These endocrine disrupting chemicals (EDCs) influence the normal activities of hormones secreted from the female hypothalamus, ovary, pituitary & uterus. The female reproductive disorders are mainly observed at embryonic or during fetal development and subsequently get matured during puberty. Various toxic chemicals and other pollutants interact with the chemical structure of the hormones and hence prolonged effects are seen at the cellu

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17

Svechnikov, K., G. Izzo, L. Landreh, J. Weisser, and O. Söder. "Endocrine Disruptors and Leydig Cell Function." Journal of Biomedicine and Biotechnology 2010 (2010): 1–10. http://dx.doi.org/10.1155/2010/684504.

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During the past decades, a large body of information concerning the effects of endocrine disrupting compounds (EDCs) on animals and humans has been accumulated. EDCs are of synthetic or natural origin and certain groups are known to disrupt the action of androgens and to impair the development of the male reproductive tract and external genitalia. The present overview describes the effects of the different classes of EDCs, such as pesticides, phthalates, dioxins, and phytoestrogens, including newly synthesized resveratrol analogs on steroidogenesis in Leydig cells. The potential impact of thes

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18

Cernasev, Alina, Amy Hall, Stacey Thomas-Gooch, and Devin Scott. "Empowering Student Pharmacists to Counsel Patients on Endocrine Disrupting Chemicals through Interactive Role-Play." Pharmacy 12, no. 2 (2024): 55. http://dx.doi.org/10.3390/pharmacy12020055.

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Preparing the next generation of pharmacists to succeed in practice and provide premier care starts with ensuring pharmacy education standards are met and align with innovative practices and that education incorporates topics that are important to promoting health. For example, recent reports link endocrine disrupting chemicals (EDCs) to numerous diseases such as reproductive disorders, metabolic diseases, and developmental abnormalities. Considering the suboptimal awareness and knowledge about EDCs, it is imperative to provide public health education through a pharmacy curriculum. The objecti

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Jiang, J. Q., Q. Yin, P. Pearce, and J. Zhou. "A survey of endocrine disrupting chemicals in sewage and a preliminary treatment trial." Water Science and Technology 52, no. 8 (2005): 1–7. http://dx.doi.org/10.2166/wst.2005.0212.

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This paper demonstrates that synthetic endocrine disrupting chemicals (EDCs) (e.g. bisphenol-A) and natural EDCs (e.g. estrone and 17β-estradiol) were found in the crude sewage from two sewage treatment works. Conventional biological processes can lower EDC concentrations to several hundred nanograms per litre. Because natural EDCs (e.g. estrone and 17β1-estradiol) have biological activity and an adverse impact on the environment at extremely low concentrations (several tens of nanograms per litre), and because the existing wastewater/sewage treatment processes are not adequate to reduce natur

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Gonsioroski, Andressa, Vasiliki E. Mourikes, and Jodi A. Flaws. "Endocrine Disruptors in Water and Their Effects on the Reproductive System." International Journal of Molecular Sciences 21, no. 6 (2020): 1929. http://dx.doi.org/10.3390/ijms21061929.

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Anthropogenic contaminants in water can impose risks to reproductive health. Most of these compounds are known to be endocrine disrupting chemicals (EDCs). EDCs can impact the endocrine system and subsequently impair the development and fertility of non-human animals and humans. The source of chemical contamination in water is diverse, originating from byproducts formed during water disinfection processes, release from industry and livestock activity, or therapeutic drugs released into sewage. This review discusses the occurrence of EDCs in water such as disinfection byproducts, fluorinated co

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Tong, Yuxiao, Manjun Xie, Hanwen Xv, Ruihua Sun, Qian Wang, and Juanying Li. "Microplastics and Endocrine Disruptors in Typical Wastewater Treatment Plants in Megacity Shanghai." Toxics 12, no. 5 (2024): 345. http://dx.doi.org/10.3390/toxics12050345.

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The fast development of China’s urbanization has led to a notable release of emerging pollutants, including microplastics (MPs) and endocrine disruptors (EDCs). Generally, these pollutants enter the coastal environment through the discharge of wastewater treatment plants (WWTPs) and finally threaten the organisms in the receiving waterbody. The study investigated the environmental behavior of MPs and EDCs in two typical WWTPs in one of the megacities in China, Shanghai. The abundance of MPs in the influent ranged from 321 to 976 items/L. Four shapes (films, fragments, fibers, and microbead) we

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Palanza, Paola, Silvia Paterlini, M. Maddalena Brambilla, et al. "Sex-biased impact of endocrine disrupting chemicals on behavioral development and vulnerability to disease: Of mice and children." Neuroscience & Biobehavioral Reviews 121 (June 12, 2021): 29–46. https://doi.org/10.5281/zenodo.13411542.

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(Uploaded by Plazi for the Bat Literature Project) Sex is a fundamental biological characteristic that influences many aspects of an organism' s phenotype, including neurobiological functions and behavior as a result of species-specific evolutionary pressures. Sex differences have strong implications for vulnerability to disease and susceptibility to environmental perturbations. Endocrine disrupting chemicals (EDCs) have the potential to interfere with sex hormones functioning and influence development in a sex specific manner. Here we present an updated descriptive review of findings from ani

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Palanza, Paola, Silvia Paterlini, M. Maddalena Brambilla, et al. "Sex-biased impact of endocrine disrupting chemicals on behavioral development and vulnerability to disease: Of mice and children." Neuroscience & Biobehavioral Reviews 121 (June 7, 2021): 29–46. https://doi.org/10.5281/zenodo.13411542.

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(Uploaded by Plazi for the Bat Literature Project) Sex is a fundamental biological characteristic that influences many aspects of an organism' s phenotype, including neurobiological functions and behavior as a result of species-specific evolutionary pressures. Sex differences have strong implications for vulnerability to disease and susceptibility to environmental perturbations. Endocrine disrupting chemicals (EDCs) have the potential to interfere with sex hormones functioning and influence development in a sex specific manner. Here we present an updated descriptive review of findings from ani

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Palanza, Paola, Silvia Paterlini, M. Maddalena Brambilla, et al. "Sex-biased impact of endocrine disrupting chemicals on behavioral development and vulnerability to disease: Of mice and children." Neuroscience & Biobehavioral Reviews 121 (June 19, 2021): 29–46. https://doi.org/10.5281/zenodo.13411542.

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(Uploaded by Plazi for the Bat Literature Project) Sex is a fundamental biological characteristic that influences many aspects of an organism' s phenotype, including neurobiological functions and behavior as a result of species-specific evolutionary pressures. Sex differences have strong implications for vulnerability to disease and susceptibility to environmental perturbations. Endocrine disrupting chemicals (EDCs) have the potential to interfere with sex hormones functioning and influence development in a sex specific manner. Here we present an updated descriptive review of findings from ani

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Palanza, Paola, Silvia Paterlini, M. Maddalena Brambilla, et al. "Sex-biased impact of endocrine disrupting chemicals on behavioral development and vulnerability to disease: Of mice and children." Neuroscience & Biobehavioral Reviews 121 (July 3, 2021): 29–46. https://doi.org/10.5281/zenodo.13411542.

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(Uploaded by Plazi for the Bat Literature Project) Sex is a fundamental biological characteristic that influences many aspects of an organism' s phenotype, including neurobiological functions and behavior as a result of species-specific evolutionary pressures. Sex differences have strong implications for vulnerability to disease and susceptibility to environmental perturbations. Endocrine disrupting chemicals (EDCs) have the potential to interfere with sex hormones functioning and influence development in a sex specific manner. Here we present an updated descriptive review of findings from ani

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Palanza, Paola, Silvia Paterlini, M. Maddalena Brambilla, et al. "Sex-biased impact of endocrine disrupting chemicals on behavioral development and vulnerability to disease: Of mice and children." Neuroscience & Biobehavioral Reviews 121 (July 10, 2021): 29–46. https://doi.org/10.5281/zenodo.13411542.

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(Uploaded by Plazi for the Bat Literature Project) Sex is a fundamental biological characteristic that influences many aspects of an organism' s phenotype, including neurobiological functions and behavior as a result of species-specific evolutionary pressures. Sex differences have strong implications for vulnerability to disease and susceptibility to environmental perturbations. Endocrine disrupting chemicals (EDCs) have the potential to interfere with sex hormones functioning and influence development in a sex specific manner. Here we present an updated descriptive review of findings from ani

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Palanza, Paola, Silvia Paterlini, M. Maddalena Brambilla, et al. "Sex-biased impact of endocrine disrupting chemicals on behavioral development and vulnerability to disease: Of mice and children." Neuroscience & Biobehavioral Reviews 121 (July 17, 2021): 29–46. https://doi.org/10.5281/zenodo.13411542.

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(Uploaded by Plazi for the Bat Literature Project) Sex is a fundamental biological characteristic that influences many aspects of an organism' s phenotype, including neurobiological functions and behavior as a result of species-specific evolutionary pressures. Sex differences have strong implications for vulnerability to disease and susceptibility to environmental perturbations. Endocrine disrupting chemicals (EDCs) have the potential to interfere with sex hormones functioning and influence development in a sex specific manner. Here we present an updated descriptive review of findings from ani

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Foster, Warren G. "Endocrine Disruption and Human Reproductive Effects: An Overview." Water Quality Research Journal 36, no. 2 (2001): 253–71. http://dx.doi.org/10.2166/wqrj.2001.015.

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Abstract Humans of all ages interact with their environment on a daily basis and are thus exposed to a variety of both man-made and naturally occurring chemicals through the air they breath, the water they drink and the food they eat. The potential for exposure to environmental contaminants to impact the function of the reproductive system and affect normal development of the reproductive tract has become an area of increasing concern at all levels of society. Environment Canada and Health Canada jointly organized a workshop to review the current state of knowledge on endocrine disrupting comp

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Lința, Adina V., Bogdan M. Lolescu, Cosmin A. Ilie, et al. "Liver and Pancreatic Toxicity of Endocrine-Disruptive Chemicals: Focus on Mitochondrial Dysfunction and Oxidative Stress." International Journal of Molecular Sciences 25, no. 13 (2024): 7420. http://dx.doi.org/10.3390/ijms25137420.

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In recent years, the worldwide epidemic of metabolic diseases, namely obesity, metabolic syndrome, diabetes and metabolic-associated fatty liver disease (MAFLD) has been strongly associated with constant exposure to endocrine-disruptive chemicals (EDCs), in particular, the ones able to disrupt various metabolic pathways. EDCs have a negative impact on several human tissues/systems, including metabolically active organs, such as the liver and pancreas. Among their deleterious effects, EDCs induce mitochondrial dysfunction and oxidative stress, which are also the major pathophysiological mechani

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Leung, Yuet-Kin. "A Silent Threat: Exploring the Impact of Endocrine Disruption on Human Health." International Journal of Molecular Sciences 24, no. 12 (2023): 9790. http://dx.doi.org/10.3390/ijms24129790.

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Endocrine-disrupting chemicals (EDCs) are chemicals, either natural or synthetic, that can interfere with the production, distribution, function, metabolism, or excretion of hormones in our body [...]

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Asenuga, E. R., and A. S. Olagunju. "EXPOSURE AND ASSOCIATED HEALTH RISK OF ENDOCRINE DISRUPTION COMPOUNDS." African Journal of Health, Safety and Environment 4, no. 1 (2023): 57–66. http://dx.doi.org/10.52417/ajhse.v4i1.332.

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Endocrine-disrupting chemicals (EDC) are an inevitable environmental pollutant due to their wide range of applications in the industrial sector. Deliberate or unkempt disposal of materials containing EDCs has also significantly contributed to its ecological exposure. Several natural and synthetic chemicals are recognized EDCs which at low doses are capable of eliciting abnormal responses in the body, this is a threat to life for both human and animal health. Due to the hormone-like nature of most of the EDCs, they have the ability to disrupt the hormone signaling pathways leading to alteration

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Banker, Margaret, Muraly Puttabyatappa, Patrick O’Day, et al. "Association of Maternal-Neonatal Steroids With Early Pregnancy Endocrine Disrupting Chemicals and Pregnancy Outcomes." Journal of the Endocrine Society 5, Supplement_1 (2021): A805. http://dx.doi.org/10.1210/jendso/bvab048.1637.

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Abstract Steroids are important for fetal development and parturition, and aberrant exposure during gestation can lead to abnormal fetal outcome. Gestational exposures to endocrine disrupting chemicals (EDCs) have the potential to alter pregnancy steroidal milieu. Most studies to date have focused on individual EDCs, when in real life humans are exposed to a host of EDCs in parallel, emphasizing the need to consider cumulative impact. To meet this goal, 121 pregnant women (18-42 years of age) were recruited between 8 and 14 weeks of gestation from Southeastern Michigan, and maternal samples at

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Jobling, S., and C. R. Tyler. "Endocrine disruption in wild freshwater fish." Pure and Applied Chemistry 75, no. 11-12 (2003): 2219–34. http://dx.doi.org/10.1351/pac200375112219.

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Endocrine disruption has been reported in freshwater fish populations around the world. This phenomenon ranges from subtle changes in the physiology and sexual behavior of fish to permanently altered sexual differentiation and impairment of fertility. Despite widespread reports of endocrine disruption in fish (and this is well characterized at the individual level), few studies have demonstrated population-level consequences as a result of exposure to endocrine-disrupting chemicals (EDCs). An exception to this is in Lake Ontario Lake trout where precipitous declines in the population have been

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Montjean, Debbie, Anne-Sophie Neyroud, Marina G. Yefimova, Moncef Benkhalifa, Rosalie Cabry, and Célia Ravel. "Impact of Endocrine Disruptors upon Non-Genetic Inheritance." International Journal of Molecular Sciences 23, no. 6 (2022): 3350. http://dx.doi.org/10.3390/ijms23063350.

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Similar to environmental factors, EDCs (endocrine-disrupting chemicals) can influence gene expression without modifying the DNA sequence. It is commonly accepted that the transgenerational inheritance of parentally acquired traits is conveyed by epigenetic alterations also known as “epimutations”. DNA methylation, acetylation, histone modification, RNA-mediated effects and extracellular vesicle effects are the mechanisms that have been described so far to be responsible for these epimutations. They may lead to the transgenerational inheritance of diverse phenotypes in the progeny when they occ

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Di Pietro, Giada, Francesca Forcucci, and Francesco Chiarelli. "Endocrine Disruptor Chemicals and Children’s Health." International Journal of Molecular Sciences 24, no. 3 (2023): 2671. http://dx.doi.org/10.3390/ijms24032671.

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We are all exposed to endocrine-disrupting chemicals (EDCs) starting from embryonic life. The fetus and child set up crucial developmental processes allowing adaptation to the environment throughout life: they are extremely sensitive to very low doses of hormones and EDCs because they are developing organisms. Considering the developmental origin of well-being and diseases, every adult organism expresses consequences of the environment in which it developed. The molecular mechanisms through which the main EDCs manifest their effects and their potential association with endocrine disorders, suc

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Amir, Saira, Syed Tahir Abbas Shah, Charalampos Mamoulakis, et al. "Endocrine Disruptors Acting on Estrogen and Androgen Pathways Cause Reproductive Disorders through Multiple Mechanisms: A Review." International Journal of Environmental Research and Public Health 18, no. 4 (2021): 1464. http://dx.doi.org/10.3390/ijerph18041464.

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Increasing contamination of the environment by toxic compounds such as endocrine disrupting chemicals (EDCs) is one of the major causes of reproductive defects in both sexes. Estrogen/androgen pathways are of utmost importance in gonadal development, determination of secondary sex characteristics and gametogenesis. Most of the EDCs mediate their action through respective receptors and/or downstream signaling. The purpose of this review is to highlight the mechanism by which EDCs can trigger antagonistic or agonistic response, acting through estrogen/androgen receptors causing reproductive defe

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Hug, Elisa, Pauline Villeneuve, Stephanie Bravard, et al. "Loss of Nuclear/DNA Integrity in Mouse Epididymal Spermatozoa after Short-Term Exposure to Low Doses of Dibutyl Phthalate or Bisphenol AF and Its Mitigation by Oral Antioxidant Supplementation." Antioxidants 12, no. 5 (2023): 1046. http://dx.doi.org/10.3390/antiox12051046.

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Routine exposure to chemicals omnipresent in the environment, particularly the so-called endocrine-disrupting chemicals (EDCs), has been associated with decreased sperm quality and increased anomalies in testis. The decline in semen quality and testicular abnormalities have been attributed to the disruption of endocrine signaling as well as oxidative stress. The present study set out to examine the effect of short-term exposure of two common EDCs widely used in the plastic industry: Dibutyl Phthalate (DBP) and Bisphenol AF (BPAF). Our research objective was to focus on the post-testicular comp

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Mentsiou Nikolaou, Evangelia, Ioanna Panagiota Kalafati, and George V. Dedoussis. "The Interplay between Endocrine-Disrupting Chemicals and the Epigenome towards Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review." Nutrients 16, no. 8 (2024): 1124. http://dx.doi.org/10.3390/nu16081124.

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Metabolic dysfunction-associated steatotic liver disease (MASLD), described as the most prominent cause of chronic liver disease worldwide, has emerged as a significant public health issue, posing a considerable challenge for most countries. Endocrine-disrupting chemicals (EDCs), commonly found in daily use items and foods, are able to interfere with nuclear receptors (NRs) and disturb hormonal signaling and mitochondrial function, leading, among other metabolic disorders, to MASLD. EDCs have also been proposed to cause transgenerationally inherited alterations leading to increased disease sus

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Petca, Aida, Nicoleta Maru, Mihai Cristian Dumitrascu, et al. "The Impact of Endocrine-Disrupting Chemicals on Female Fertility." Revista de Chimie 71, no. 6 (2020): 286–94. http://dx.doi.org/10.37358/rc.20.6.8194.

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Nowadays, infertility is a prevalent problem among couples. Exposure to endocrine-disrupting chemicals (EDCs) may influence the female reproductive outcomes through multiple mechanisms, being one of the important causes of infertility. These compounds may interfere with some fertility and fecundity markers, leading to increased time to pregnancy, increased risk of spontaneous abortion, shorter menstrual cycles, early age at menopause, anovulation or delayed ovulation, smaller preovulatory follicles, increased serum FSH, decreased synthesis of estradiol and progesterone, low plasma levels of an

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Bhapkar, Tejal, Swati Umap, A. P. Somkuwar, Alka Sawarkar, Gauri Deshmukh, and M. M. Purankar. "Swimming Through Science: Unveiling the Secrets of Endocrine Disruptors with Zebrafish Models." Chronicle of Aquatic Science 10, no. 01 (2024): 115–29. http://dx.doi.org/10.61851/coas.v1i10.11.

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The utilization of zebrafish (Danio rerio) as a model organism in studying endocrine disruptor chemicals (EDCs) has emerged as a powerful and versatile approach in toxicology research. This review highlights the numerous advantages that make zebrafish an ideal model for assessing the impact of EDCs on endocrine systems. Zebrafish, with their high fecundity, transparent embryos and rapid development, offer a cost-effective and time-efficient platform for observing the effects of EDC exposure on various endocrine-related pathways. Furthermore, the zebrafish’s amenability to genetic manipulation

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Shree, Nitya, Zehuan Ding, Jodi Flaws, and Mahua Choudhury. "Role of microRNA in Endocrine Disruptor-Induced Immunomodulation of Metabolic Health." Metabolites 12, no. 11 (2022): 1034. http://dx.doi.org/10.3390/metabo12111034.

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The prevalence of poor metabolic health is growing exponentially worldwide. This condition is associated with complex comorbidities that lead to a compromised quality of life. One of the contributing factors recently gaining attention is exposure to environmental chemicals, such as endocrine-disrupting chemicals (EDCs). Considerable evidence suggests that EDCs can alter the endocrine system through immunomodulation. More concerning, EDC exposure during the fetal development stage has prominent adverse effects later in life, which may pass on to subsequent generations. Although the mechanism of

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Nelson, William, Ding-Yuan Liu, Yin Yang, Zhao-Hui Zhong, Ying-Xiong Wang, and Yu-bin Ding. "In utero exposure to persistent and nonpersistent endocrine-disrupting chemicals and anogenital distance. A systematic review of epidemiological studies†." Biology of Reproduction 102, no. 2 (2019): 276–91. http://dx.doi.org/10.1093/biolre/ioz200.

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Abstract Anti-androgenic endocrine-disrupting chemicals (EDCs) can cross the placenta to modify early offspring sexual dimorphic markers. These changes are linked to anogenital distance (AGD), which is an androgen-sensitive anthropometric parameter used as a biomarker of perineal growth and caudal migration of the genital tubercle. This review aimed to summarize strength of evidence for associations of in utero exposure to EDCs with AGD and to identify gaps and limitations in the literature so as to inform future research. We performed an electronic search of English literature in September 20

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LOGAPRAKASH, P., and C. MONİCA. "Optimal control of diabetes model with the impact of endocrine-disrupting chemical: an emerging increased diabetes risk factor." Mathematical Modelling and Numerical Simulation with Applications 3, no. 4 (2023): 318–34. http://dx.doi.org/10.53391/mmnsa.1397575.

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Diabetes, a persistent pathological condition characterized by disruptions in insulin hormone regulation, has exhibited a noteworthy escalation in its prevalence over recent decades. The surge in incidence is notably associated with the proliferation of endocrine-disrupting chemicals (EDCs), which have emerged as primary contributors to the manifestation of insulin resistance and the consequent disruption of beta cell function, ultimately culminating in the onset of diabetes. Consequently, this study endeavors to introduce a model for diabetes that aims to elucidate the ramifications of exposu

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Joshi, Shreya N., and Purvi Bhatt. "Effects of bisphenol A, phthalates and triclosan on gut microbiome and its impact on host pathophysiology across different species." International Journal of Scientific Reports 9, no. 3 (2023): 80–91. http://dx.doi.org/10.18203/issn.2454-2156.intjscirep20230379.

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Environmental pollutants like endocrine disrupting chemicals (EDCs), unhealthy lifestyle and genetic predisposition have a major impact on the gut microbiota leading to dysbiosis, thus causing chronic diseases. This narrative review highlights the impact of three most common EDCs, bisphenol A (BPA), phthalates and triclosan in terms of increase in opportunistic pathogens, alterations in host metabolic profiles and immune response and associated pathophysiological changes across different species. BPA exposure led to a significant increase in Bacteroides, Firmicutes, Proteobacteria and Akkerman

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Gil, Moisés L., Estefan M. da Fonseca, Bruno S. Pierri, et al. "The Consequences of a Lack of Basic Sanitation in the Municipality of Maricá (Rio de Janeiro, Brazil) Resulting in Low Concentrations of Metals but Dissemination of Endocrine Disruptors Through Local Environments: Subsidies for Local Environmental Management." Eng 5, no. 4 (2024): 3467–87. https://doi.org/10.3390/eng5040181.

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Endocrine-disrupting compounds (EDCs) are emerging pollutants that can potentially accumulate in aquatic ecosystems at significant levels, with the potential to impact the health of both animals and humans. Many scientists have correlated human exposure to high concentrations of EDCs with critical physiological impacts, including infertility, thyroid imbalance, early sexual development, endometriosis, diabetes, and obesity. Several substances, such as heavy metals, belong to this family, ranging from natural to synthetic compounds, including pesticides, pharmaceuticals, and plastic-derived com

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Socha, Magdalena, Jarosław Chyb, Aleksandra Suder, and Bartosz Bojarski. "How endocrine disruptors affect fish reproduction on multiple levels: A review." Fisheries & Aquatic Life 32, no. 3 (2024): 128–36. https://doi.org/10.2478/aopf-2024-0012.

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Abstract This review paper presents fish reproductive toxicology studies with a specific focus on endocrine-disrupting chemicals (EDCs) present in the aquatic environment. These substances, including bisphenols, heavy metals, pesticides, phthalates, and polychlorinated biphenyls (PCBs), act as hormone mimics, receptor blockers, or enzyme inhibitors that affect hormonal regulation in the hypothalamic-pituitary-gonadal (HPG) axis. In this review, we provide an overview of the adverse effects of these pollutants on both female and male fish reproduction (i.e., hormonal disruption in the HPG axis,

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Pestana, Diogo, Diana Teixeira, Carla Sá, et al. "The Role of Endocrine Disruptors on Metabolic Dysfunction." Open Biotechnology Journal 10, no. 1 (2016): 108–21. http://dx.doi.org/10.2174/1874070701610010108.

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Abdominal obesity appears to be an important component of the metabolic syndrome (MetS), in which along with insulin resistance, hypertension and dyslipidaemia represents an increased risk for developing cardiovascular diseases and type 2 diabetes (T2D). The aetiology of obesity and its comorbidities is multifactorial, but despite the evidence of traditional contributing factors, the role of environmental toxicants with endocrine disrupting activity has been recently highlighted. Indeed, even small concentrations of these endocrine disrupting chemicals (EDCs) have the ability to cause severe h

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Dsouki, Nuha Ahmad, Bruno Fiorelini Pereira, Roberta Goes da Silva, et al. "The Interplay of the Mammalian Brain and Thyroid Hormones, and the Threat of Endocrine-Disrupting Chemicals." Endocrines 5, no. 4 (2024): 501–15. http://dx.doi.org/10.3390/endocrines5040036.

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Introduction: During the formation of neural circuits, the developing brain demonstrates extraordinary plasticity, heavily influenced by hormones. These chemical messengers interact with specific receptors to regulate vital physiological functions. The thyroid gland plays a pivotal role in maintaining hormonal balance and guiding brain development. However, emerging threats like endocrine-disrupting chemicals (EDCs) can interfere with this intricate system. EDCs are exogenous substances that can mimic, enhance, or block the actions of endogenous hormones, disrupting hormonal signaling in the b

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Virant-Klun, Irma, Senka Imamovic-Kumalic, and Bojana Pinter. "From Oxidative Stress to Male Infertility: Review of the Associations of Endocrine-Disrupting Chemicals (Bisphenols, Phthalates, and Parabens) with Human Semen Quality." Antioxidants 11, no. 8 (2022): 1617. http://dx.doi.org/10.3390/antiox11081617.

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Exposure to endocrine-disrupting chemicals (EDCs) may result in oxidative stress and endocrine system disturbance, which can have an impact on human reproduction and development. In male reproductive health, EDCs have been related to impaired reproductive function and male infertility, altered fetal development, and testicular germ-cell, prostate, and breast cancers. We conducted an electronic search using PubMed on endocrine disruptors related to oxidative stress and male infertility, and evaluated their association with endocrine-disrupting chemicals (bisphenols, phthalates, and parabens) in

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Rolfo, Alessandro, Anna Maria Nuzzo, Ramona De Amicis, Laura Moretti, Simona Bertoli, and Alessandro Leone. "Fetal–Maternal Exposure to Endocrine Disruptors: Correlation with Diet Intake and Pregnancy Outcomes." Nutrients 12, no. 6 (2020): 1744. http://dx.doi.org/10.3390/nu12061744.

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Endocrine-disrupting chemicals (EDCs) are exogenous substances able to mimic or to interfere with the endocrine system, thus altering key biological processes such as organ development, reproduction, immunity, metabolism and behavior. High concentrations of EDCs are found in several everyday products including plastic bottles and food containers and they could be easily absorbed by dietary intake. In recent years, considerable interest has been raised regarding the biological effects of EDCs, particularly Bisphenol A (BPA) and phthalates, on human pregnancy and fetal development. Several evide

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