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Journal articles on the topic 'Editing genetico germinale'

Author: Grafiati

Published: 9 March 2023

Last updated: 19 July 2025

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1

Sutton, Agneta. "Editing della linea germinale: quali sono i rischi sociali e morali? / Germ-line gene editing: What are the social and moral risks?" Medicina e Morale 65, no. 2 (2016): 123–30. http://dx.doi.org/10.4081/mem.2016.430.

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Dovremmo accogliere tutti i possibili sviluppi dell’editing genetico? L’editing genetico delle cellule somatiche potrebbe essere considerato alla pari delle terapie convenzionali volte a trattare particolari patologie o ad alleviarne i sintomi. Tale intervento interesserebbe esclusivamente il singolo paziente trattato. Esso potrebbe quindi essere ben accolto come un nuovo tipo di trattamento per i tumori e le malattie del sangue, come ad esempio la beta-talassemia. Diversamente, l’editing della linea germinale avrebbe effetti ereditari. Ciò solleva preoccupazioni particolari riguardo al rischi

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2

Iqbal, Gowhar, Nahida Quyoom, Lukram Sushil Singh, et al. "Genome Editing Technology in Fishes." Current Journal of Applied Science and Technology 42, no. 23 (2023): 20–26. http://dx.doi.org/10.9734/cjast/2023/v42i234170.

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Genome editing and silencing techniques can transform the biology that we understand, diseases affecting fish and other aquatic animals. Gene editing is now being tested in aquaculture, reproduction control, sterility, and disease resistance aspects. More money must be invested in innovative technology to solve these issues in this industry. So gene silencing and genomic DNA editing have the potential significant impact on aquatic animal treatment in the future. Genome editing in fish is an interested part of research that has the potential to revolutionize aquaculture and aid in the understan

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3

Ben Shlush, Ilan Ben, Aviva Samach, Cathy Melamed-Bessudo, et al. "CRISPR/Cas9 Induced Somatic Recombination at the CRTISO Locus in Tomato." Genes 12, no. 1 (2020): 59. http://dx.doi.org/10.3390/genes12010059.

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Homologous recombination (HR) in somatic cells is not as well understood as meiotic recombination and is thought to be rare. In a previous study, we showed that Inter-Homologous Somatic Recombination (IHSR) can be achieved by targeted induction of DNA double-strand breaks (DSBs). Here, we designed a novel IHSR assay to investigate this phenomenon in greater depth. We utilized F1 hybrids from divergent parental lines, each with a different mutation at the Carotenoid isomerase (CRTISO) locus. IHSR events, namely crossover or gene conversion (GC), between the two CRTISO mutant alleles (tangerine

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4

Henderson, Sam W., Steven T. Henderson, Marc Goetz, and Anna M. G. Koltunow. "Efficient CRISPR/Cas9-Mediated Knockout of an Endogenous PHYTOENE DESATURASE Gene in T1 Progeny of Apomictic Hieracium Enables New Strategies for Apomixis Gene Identification." Genes 11, no. 9 (2020): 1064. http://dx.doi.org/10.3390/genes11091064.

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Most Hieracium subgenus Pilosella species are self-incompatible. Some undergo facultative apomixis where most seeds form asexually with a maternal genotype. Most embryo sacs develop by mitosis, without meiosis and seeds form without fertilization. Apomixis is controlled by dominant loci where recombination is suppressed. Loci deletion by γ-irradiation results in reversion to sexual reproduction. Targeted mutagenesis of genes at identified loci would facilitate causal gene identification. In this study, the efficacy of CRISPR/Cas9 editing was examined in apomictic Hieracium by targeting mutatio

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5

Barberini, Sara, Chiara Forti, Marina Laura, et al. "An Optimized Protocol for In Vitro Regeneration of Ocimum basilicum cv. FT Italiko." Horticulturae 9, no. 3 (2023): 407. http://dx.doi.org/10.3390/horticulturae9030407.

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Sweet basil (Ocimum basilicum L.; Fam. Lamiaceae) is an annual herbaceous plant with a high economic value used in folk medicine, pharmacology, and food production. In Italy, most of the varieties are used to produce the famous “pesto” sauce; however, almost all of them are susceptible to basil downy mildew (BDM) disease, strongly decreasing the growth of the fresh leaves and the survival of the whole plant. Nowadays, CRISPR/Cas9 technology is recognized to be a prominent way to enhance basil genetic breeding. In this work, we present an optimized protocol for in vitro direct regeneration of a

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6

Hoang, Doan, and Simon Hoang. "Deep learning - cancer genetics and application of deep learning to cancer oncology." Vietnam Journal of Science and Technology 60, no. 6 (2022): 885–928. http://dx.doi.org/10.15625/2525-2518/17256.

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Arguably the human body has been one of the most sophisticated systems we encounter but until now we are still far from understanding its complexity. We have been trying to replicate human intelligence by way of artificial intelligence but with limited success. We have discovered the molecular structure in terms of genetics, performed gene editing to change an organism’s DNA and much more, but their translatability into the field of oncology has remained limited. Conventional machine learning methods achieved some degree of success in solving problems that we do not have an explicit algorithm.

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7

Pasqualucci, Laura, Mara Compagno, Tongwei Mo, et al. "Activation Induced Cytidine Deaminase (AID) Is Required for Germinal-Center Derived Lymphomagenesis." Blood 108, no. 11 (2006): 223. http://dx.doi.org/10.1182/blood.v108.11.223.223.

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Abstract Most B cell non-Hodgkin’s lymphomas (B-NHL) derive from germinal center (GC) B cells and their pathogenesis is associated with the accumulation of distinct genetic lesions, including chromosomal translocations and a more recently identified mechanism of genomic instability, termed aberrant somatic hypermutation. These alterations are thought to be due to mistakes occurring during two GC-associated immunoglobulin (Ig) genes remodeling processes: class switch recombination (CSR) and somatic hypermutation (SHM). However, this model has never been formally proven. To conclusively investig

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8

Patel, Amit K., Risa M. Broyer, Cassidy D. Lee, et al. "Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons." Proceedings of the National Academy of Sciences 117, no. 52 (2020): 33597–607. http://dx.doi.org/10.1073/pnas.2004683117.

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Axon injury is a hallmark of many neurodegenerative diseases, often resulting in neuronal cell death and functional impairment. Dual leucine zipper kinase (DLK) has emerged as a key mediator of this process. However, while DLK inhibition is robustly protective in a wide range of neurodegenerative disease models, it also inhibits axonal regeneration. Indeed, there are no genetic perturbations that are known to both improve long-term survival and promote regeneration. To identify such a neuroprotective target, we conducted a set of complementary high-throughput screens using a protein kinase inh

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9

Ross, Aisling M., Ciara I. Leahy, Fiona Neylon, et al. "Epstein–Barr Virus and the Pathogenesis of Diffuse Large B-Cell Lymphoma." Life 13, no. 2 (2023): 521. http://dx.doi.org/10.3390/life13020521.

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Epstein–Barr virus (EBV), defined as a group I carcinogen by the World Health Organization (WHO), is present in the tumour cells of patients with different forms of B-cell lymphoma, including Burkitt lymphoma, Hodgkin lymphoma, post-transplant lymphoproliferative disorders, and, most recently, diffuse large B-cell lymphoma (DLBCL). Understanding how EBV contributes to the development of these different types of B-cell lymphoma has not only provided fundamental insights into the underlying mechanisms of viral oncogenesis, but has also highlighted potential new therapeutic opportunities. In this

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10

Ten Hacken, Elisa, Shanye Yin, Kendell Clement, et al. "Interrogation of Individual CLL Loss-of-Function Lesions By CRISPR In Vivo Editing Reveals Common and Unique Pathway Alterations." Blood 134, Supplement_1 (2019): 684. http://dx.doi.org/10.1182/blood-2019-127673.

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Mouse models represent invaluable tools for the systematic evaluation of cancer drivers, yet models that address the impact of putative genetic drivers of chronic lymphocytic leukemia (CLL) on B cell development and function are largely lacking. To study recurrent loss-of-function (LOF) mutations observed in human CLL, we established a transplant model that can rapidly evaluate genetic lesions. First, we crossed mice carrying B-cell restricted Cre expression (Cd19-cre) with mice carrying conditional Cas9-GFP, to generate a strain expressing B cell-restricted Cas9 (Cd19-Cas9). Next, we optimize

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11

Barbati, Zachary R., and Yann Charli-Joseph. "Unveiling Primary Cutaneous B-Cell Lymphomas: New Insights into Diagnosis and Treatment Strategies." Cancers 17, no. 7 (2025): 1202. https://doi.org/10.3390/cancers17071202.

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Background/Objectives: Primary cutaneous B-cell lymphomas (PCBCL) are a rare and heterogeneous group of non-Hodgkin lymphomas that are confined to the skin at diagnosis and exhibit a tendency for cutaneous recurrence. The 5th edition of the World Health Organization and the 2022 International Consensus Classification recognize three main subtypes: primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma/lymphoproliferative disorder (PCMZL/LPD), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL,LT). These subtypes differ in clinical behav

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12

Takata, Katsuyoshi, Daisuke Ennishi, Ali Bashashati, et al. "Somatic PRAME Deletions Are Associated with Decreased Immunogenicity, Apoptosis Resistance and Poor Outcomes in Diffuse Large B-Cell Lymphoma." Blood 132, Supplement 1 (2018): 667. http://dx.doi.org/10.1182/blood-2018-99-113516.

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Abstract Background: The current standard of care in diffuse large B-cell lymphoma (DLBCL) consists of chemotherapy and therapeutic monoclonal antibodies that have significantly improved patient outcomes over the past 15 years. However, a large proportion of patients suffer from refractory or relapsed disease. Therefore, the development of new therapeutic strategies for this subgroup of patients, who are threatened by a high chance of disease-related death, represents an important unmet clinical need. Methods: We enrolled into our study 347 de novo DLBCL patients uniformly treated with R-CHOP

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13

Navarro, M., C. Bluguermann, M. Von Meyeren, V. Bariani, C. Osycka, and A. Mutto. "2 Role of histone H3 lysine 9 trimethylation during bovine pre-implantation embryonic development." Reproduction, Fertility and Development 31, no. 1 (2019): 126. http://dx.doi.org/10.1071/rdv31n1ab2.

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Histones play an important role in DNA’s compaction and organisation into the cellular nucleus. Depending on which histone modification occurs, chromatin can take a conformation of heterochromatin or euchromatin, which are associated with gene repression or expression, respectively. Histone H3 lysine 9 (H3K9) trimethylation (H3K9me3) is associated with gene silencing. At least 3 methyltransferases are able to change the methylation status of H3K9: SUV39H1, SUV39H2, and SETDB1. In several mammalian species, modulation of H3K9 methylation status has been demonstrated to be necessary to achieve a

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14

Li, Michael Y., Lauren C. Chong, Elizabeth Chavez та ін. "TRAF3 Loss Drives Alternative NF-κB Pathway Activation in Diffuse Large B-Cell Lymphoma". Blood 136, Supplement 1 (2020): 22–23. http://dx.doi.org/10.1182/blood-2020-141126.

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Introduction: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor family that regulates gene expression programs contributing to inflammation and cell survival. NF-κB signaling occurs via two branches: classical and alternative, and is often enriched in somatic mutations of key pathway members in several lymphoid malignancies. Here, we reveal deregulation and constitutive activation of the alternative NF-κB pathway in a subset of DLBCL patients with recurrent genomic loss of the gene encoding tumor necrosis factor receptor-associated factor 3 (TRAF3

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15

Pasqualucci, Laura, Mara Compagno, Wei Keat Lim, et al. "Mutations in Multiple Genes Cause Deregulation of the NFkB Pathway in Diffuse Large B-Cell Lymphoma." Blood 112, no. 11 (2008): 801. http://dx.doi.org/10.1182/blood.v112.11.801.801.

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Abstract Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease comprising multiple biologically and clinically distinct subgroups, including germinal center B cell-like (GCB) and activated B cell-like (ABC) DLBCL. Gene expression profile studies have shown that a key feature of its most aggressive subtype, ABC-DLBCL, is the constitutive activation of the NF-kB transcription complex. However, except for a small fraction of cases (Lenz et al., Science 2008), it remains unclear whether NF-kB activation in these tumors reflects an intrinsic program of the cell of origin or represents a

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16

Anubha, Bajaj*. "The Remedial Anabasis- Cancer Stem Cells." Biomedical Research and Reviews (ISSN:2631-3944) 2, no. 2 (2019): 1–3. https://doi.org/10.31021/brr.20192111.

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<strong>Premise and Principle</strong> Emergence of cancer is contemplated as a genetic phenomenon wherein genetic evolution of malignant cells modifies the progression of individual tumour. Genetic mutations are a conjectural phenomenon and unsynchronized mutational configurations can appear. Accumulations of cancer cells articulate a dynamic environment comprised of multiple, heterogeneous tumour cell territories and distinctive molecular signatures pertaining to diverse malignancies with cogent genomic mutations. Fundamental biological processes as designated with committed cancer stem cell

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17

Takata, Katsuyoshi, Lauren C. Chong, Daisuke Ennishi, et al. "The Tumor Associated Antigen PRAME Exhibits Dualistic Functions That Are Targetable in Diffuse Large B-Cell Lymphoma." Blood 136, Supplement 1 (2020): 34. http://dx.doi.org/10.1182/blood-2020-141168.

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Background: With the goal of translating biological discovery into clinical actionability, deciphering crosstalk in the cellular ecosystem of the tumor microenvironment (TME) has emerged as a research focus. Although comparatively little is known about the immune biology of diffuse large B-cell lymphoma (DLBCL), as reflected in clonal selection of specific somatic gene mutations in response to immune system pressure and the specific composition of the TME, PRAME has emerged as a prominent member of the cancer germline antigen/ tumor associated antigen (TAA) family of proteins. It is expressed

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18

Maffei, Rossana, Stefania Fiorcari, Claudio Giacinto Atene, et al. "The dynamic functions of IRF4 in B cell malignancies." Clinical and Experimental Medicine, December 10, 2022. http://dx.doi.org/10.1007/s10238-022-00968-0.

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AbstractThe trajectory of B cell development goes through subsequent steps governed by complex genetic programs, strictly regulated by multiple transcription factors. Interferon regulatory factor 4 (IRF4) regulates key points from pre-B cell development and receptor editing to germinal center formation, class-switch recombination and plasma cell differentiation. The pleiotropic ability of IRF4 is mediated by its “kinetic control”, allowing different IRF4 expression levels to activate distinct genetic programs due to modulation of IRF4 DNA-binding affinity. IRF4 is implicated in B cell malignan

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19

Li, Quanlin, Wenxue Zhai, Jiaping Wei, and Yanfeng Jia. "Rice lipid transfer protein, OsLTPL23, controls seed germination by regulating starch-sugar conversion and ABA homeostasis." Frontiers in Genetics 14 (January 16, 2023). http://dx.doi.org/10.3389/fgene.2023.1111318.

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Seed germination is vital for ensuring the continuity of life in spermatophyte. High-quality seed germination usually represents good seedling establishment and plant production. Here, we identified OsLTPL23, a putative rice non-specific lipid transport protein, as an important regulator responsible for seed germination. Subcellular localization analysis confirmed that OsLTPL23 is present in the plasma membrane and nucleus. The knockout mutants of OsLTPL23 were generated by CRISPR/Cas9-mediated genome editing, and osltpl23 lines significantly germinated slower and lower than the Nipponbare (NI

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20

Ross, AM, CI Leahy, F. Neylon, et al. "Epstein–Barr Virus and the Pathogenesis of Diffuse Large B-Cell Lymphoma." February 14, 2023. https://doi.org/10.5281/zenodo.8157492.

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Epstein–Barr virus (EBV), defined as a group I carcinogen by the World Health Organization (WHO), is present in the tumour cells of patients with different forms of B-cell lymphoma, including Burkitt lymphoma, Hodgkin lymphoma, post-transplant lymphoproliferative disorders, and, most recently, diffuse large B-cell lymphoma (DLBCL). Understanding how EBV contributes to the development of these different types of B-cell lymphoma has not only provided fundamental insights into the underlying mechanisms of viral oncogenesis, but has also highlighted potential new therapeutic opportunities. I

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21

Poddar, Snigdha, Jaclyn Tanaka, Jamie H. D. Cate, Brian Staskawicz, and Myeong-Je Cho. "Efficient isolation of protoplasts from rice calli with pause points and its application in transient gene expression and genome editing assays." Plant Methods 16, no. 1 (2020). http://dx.doi.org/10.1186/s13007-020-00692-4.

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Abstract Background An efficient in vivo transient transfection system using protoplasts is an important tool to study gene expression, metabolic pathways, and multiple mutagenesis parameters in plants. Although rice protoplasts can be isolated from germinated seedlings or cell suspension culture, preparation of those donor tissues can be inefficient, time-consuming, and laborious. Additionally, the lengthy process of protoplast isolation and transfection needs to be completed in a single day. Results Here we report a protocol for the isolation of protoplasts directly from rice calli, without

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22

Murugan, Theivanai, Om Prakash Awasthi, Sanjay Kumar Singh, et al. "Molecular and histological validation of modified in ovulo nucellus culture based high-competency direct somatic embryogenesis and amplitude true-to-the-type plantlet recovery in Kinnow mandarin." Frontiers in Plant Science 14 (March 8, 2023). http://dx.doi.org/10.3389/fpls.2023.1116151.

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Kinnow (Citrus nobilis Lour. × Citrus deliciosa Ten.) needs to be genetically improved for traits such as seedlessness using biotechnological tools. Indirect somatic embryogenesis (ISE) protocols have been reported for citrus improvement. However, its use is restricted due to frequent occurrences of somaclonal variation and low recovery of plantlets. Direct somatic embryogenesis (DSE) using nucellus culture has played a significant role in apomictic fruit crops. However, its application in citrus is limited due to the injury caused to tissues during isolation. Optimization of the explant devel

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