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Journal articles on the topic 'EDST'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Touzene, A. R., and K. Day. "On Directed Edge-Disjoint Spanning Trees in Product Networks, An Algorithmic Approach." Journal of Engineering Research [TJER] 11, no. 2 (December 1, 2014): 79. http://dx.doi.org/10.24200/tjer.vol11iss2pp79-88.

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In (Ku et al. 2003), the authors have proposed a construction of edge-disjoint spanning trees EDSTs in undirected product networks. Their construction method focuses more on showing the existence of a maximum number (n1+n2-1) of EDSTs in product network of two graphs, where factor graphs have respectively n1 and n2 EDSTs. In this paper, we propose a new systematic and algorithmic approach to construct (n1+n2) directed routed EDST in the product networks. The direction of an edge is added to support bidirectional links in interconnection networks. Our EDSTs can be used straightforward to develo

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McEvoy, Matthew D., William R. Hand, Marjorie P. Stiegler, Amy N. DiLorenzo, Jesse M. Ehrenfeld, Kenneth R. Moran, Robert Lekowski, et al. "A Smartphone-based Decision Support Tool Improves Test Performance Concerning Application of the Guidelines for Managing Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy." Anesthesiology 124, no. 1 (January 1, 2016): 186–98. http://dx.doi.org/10.1097/aln.0000000000000885.

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Abstract Background The American Society of Regional Anesthesia and Pain Medicine (ASRA) consensus statement on regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy is the standard for evaluation and management of these patients. The authors hypothesized that an electronic decision support tool (eDST) would improve test performance compared with native physician behavior concerning the application of this guideline. Methods Anesthesiology trainees and faculty at 8 institutions participated in a prospective, randomized trial in which they completed a 20-question t

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Pawa, S., K. Van Aarsen, A. Dukelow, D. Lizotte, and M. Zheng. "MP04: Interim analysis of the impact of the Emergency Department Transformation System on ambulance offload delay." CJEM 19, S1 (May 2017): S66. http://dx.doi.org/10.1017/cem.2017.170.

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Introduction: Emergency Department Systems Transformation (EDST) is a bundle of Toyota Production System based interventions implemented in two London, Canada tertiary care Emergency Departments (ED) between April 2014 and July 2016 to improve patient care by increasing value and reducing waste. Some of the 17 primary interventions included computerized physician order entry optimization, staff schedule realignment, physician scorecards, and a novel initial assessment process. Offload delays are associated with longer hospital length of stay and delayed admission, and may increase morbidity an

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Danby, S., K. Van Aarsen, M. Columbus, and A. Dukelow. "LO06: Effects of emergency department system transformation (EDST) on patient experience of emergency department visits." CJEM 20, S1 (May 2018): S8. http://dx.doi.org/10.1017/cem.2018.68.

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Introduction: Emergency Department Systems Transformation (EDST) is a bundle of Toyota Production System based interventions partially implemented in two Canadian tertiary care Emergency Departments (ED) between June 2014- July 2016 with the goal to improve patient care by increasing value and reducing waste. Some of the 17 primary interventions included computerized physician order entry optimization, staff schedule realignment, physician scorecards and a novel initial assessment process. Some interventions have only been partially implemented due to persistent access block. This project was

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Tsuei, J. J., F. M. K. Lam, and Pesus Chou. "Clinical applications of the EDST." IEEE Engineering in Medicine and Biology Magazine 15, no. 3 (1996): 67–75. http://dx.doi.org/10.1109/51.499761.

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Stanczak, Magda, Teresa Fras, Ludovic Blanc, Piotr Pawlowski, and Alexis Rusinek. "Blast-Induced Compression of a Thin-Walled Aluminum Honeycomb Structure—Experiment and Modeling." Metals 9, no. 12 (December 15, 2019): 1350. http://dx.doi.org/10.3390/met9121350.

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The presented discussion concerns the behavior of a thin-walled hexagonal aluminum honeycomb structure subjected to blast loading. The shock wave affecting the structure is generated by detonation of the C4 charge in an explosive-driven shock tube (EDST). The EDST set-up is an instrumented device that makes it possible to study blast effects in more stable and repeatable conditions than those obtained in a free-air detonation. The formation of folds characteristic of a honeycomb deformation in the axial compression distributes the initial loading over a time period, which is considered as an e

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Dukelow, A., K. Van Aarsen, C. MacDonald, and V. Dagnone. "P036: Interim analysis of the impact of the emergency department transformation system on flow metrics." CJEM 20, S1 (May 2018): S69. http://dx.doi.org/10.1017/cem.2018.234.

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Introduction: Emergency Department Systems Transformation (EDST) is a bundle of Toyota Production System based interventions implemented in two Canadian tertiary care Emergency Departments (ED) between June 2014 to July 2016. The goals were to improve patient care by increasing value and reducing waste. Longer times to physician initial assessment (PIA), ED length of stays (LOS) and times to inpatient beds are associated with increased patient morbidity and potentially mortality. Some of the 17 primary interventions included computerized physician order entry optimization, staff schedule reali

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8

Kuo-Gen Chen. "Applying quantum interference to EDST medicine testing." IEEE Engineering in Medicine and Biology Magazine 15, no. 3 (1996): 64–66. http://dx.doi.org/10.1109/51.499760.

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A., Ademuyiwa J., and Adetunji A. A. "Impact of Some Economic Variables on the Real Gross Domestic Product of Nigeria." Budapest International Research and Critics Institute (BIRCI-Journal) : Humanities and Social Sciences 2, no. 4 (November 6, 2019): 12–19. http://dx.doi.org/10.33258/birci.v2i4.563.

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The influences of External Debt Service (EDS), External Debt Stock (EDSt), Government Expenditure (GE), Inflation Rate (InfR), Interest Rate (IntR) and Exchange Rate (ExR) of Nigeria on the Real Gross Domestic Product (RGDP) are examined. Results of the analysis using Stepwise Regression (Backward Elimination and Forward Selection) reveals that GE, EDS, and IntR have positive significant contributions to the RGDP of the country compared to other variables considered.

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Sun, Baoli, Luciana L. Prates, and Peiqiang Yu. "Interactive Curve-Linear Relationship Between Alteration of Carbohydrate Macromolecular Structure Traits in Hulless Barley (Hordeum vulgare L.) Grain and Nutrient Utilization, Biodegradation and Bioavailability." International Journal of Molecular Sciences 20, no. 6 (March 18, 2019): 1366. http://dx.doi.org/10.3390/ijms20061366.

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The aim of this study was to reveal an interactive curve-linear relationship between altered carbohydrate macromolecular structure traits of hulless barley cultivars and nutrient utilization, biodegradation, as well as bioavailability. The cultivars had different carbohydrate macromolecular traits, including amylose (A), amylopectin (AP), and β-glucan contents, as well as their ratios (A:AP). The parameters assessed included: (1) chemical and nutrient profiles; (2) protein and carbohydrate sub-fractions partitioned by the Cornell Net Carbohydrate and Protein System (CNCPS); (3) total digestibl

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Stanczak, M., T. Fras, L. Blanc, P. Pawlowski, and A. Rusinek. "Numerical and experimental study on mechanical behaviour of the AlSi10Mg aluminium structures manufactured additively and subjected to a blast wave." EPJ Web of Conferences 250 (2021): 02017. http://dx.doi.org/10.1051/epjconf/202125002017.

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The paper is related to energy absorptive properties of additively manufactured metallic cellular structures. The samples of Honeycomb, Auxetic, rhomboidal Lattice and a regular Foam are subjected to a dynamic compression due to the blast tests. The cuboidal samples are manufactured by the Direct Metal Laser Sintering (DMLS) method using AlSi10Mg aluminium powder. The experimental tests are performed by means of an Explosive Driven Shock Tube (EDST). The measured results of the transmitted forces in relation to the shortening of the samples allow to analyse the deformation processes of each se

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Bal, Harshawardhan P., and Janendra K. Batra. "Human Pancreatic Ribonuclease. Deletion of the Carboxyl-Terminal EDST Extension Enhances Ribonuclease Activity and Thermostability." European Journal of Biochemistry 245, no. 2 (April 15, 1997): 465–69. http://dx.doi.org/10.1111/j.1432-1033.1997.t01-1-00465.x.

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Love, Andrew J., Valérie Laval, Chiara Geri, Janet Laird, A. Deri Tomos, Mark A. Hooks, and Joel J. Milner. "Components of Arabidopsis Defense- and Ethylene-Signaling Pathways Regulate Susceptibility to Cauliflower mosaic virus by Restricting Long-Distance Movement." Molecular Plant-Microbe Interactions® 20, no. 6 (June 2007): 659–70. http://dx.doi.org/10.1094/mpmi-20-6-0659.

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We analyzed the susceptibility of Arabidopsis mutants with defects in salicylic acid (SA) and jasmonic acid (JA)/ethylene (ET) signaling to infection by Cauliflower mosaic virus (CaMV). Mutants cpr1-1 and cpr5-2, in which SA-dependent defense signaling is activated constitutively, were substantially more resistant than the wild type to systemic infection, implicating SA signaling in defense against CaMV. However, SA-deficient NahG, sid2-2, eds5-1, and pad4-1 did not show enhanced susceptibility. A cpr5 eds5 double mutant also was resistant, suggesting that resistance in cpr5 may function parti

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Khanuja, Harmeet Kaur, and Dr D. S. Adane. "Forensic Analysis of Databases by Combining Multiple Evidences." INTERNATIONAL JOURNAL OF COMPUTERS & TECHNOLOGY 7, no. 3 (June 10, 2013): 654–63. http://dx.doi.org/10.24297/ijct.v7i3.3446.

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The information security for securing enterprise databases from internal and external attacks and violations of mutual policy is an interminable struggle. With the growing number of attacks and frauds, the organizations are finding it difficult to meet various regulatory compliance requirements such as SOX, HIPAA, and state privacy laws. The aim here is to develop a methodology which monitors the database transactions on continuous basis and to make a decision whether the database transactions are legitimate or suspicious by combining multiple evidences gathered. The suspicious transactions ca

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Battikh, Dalia, Safwan El El Assad, Thang Manh Hoang, Bassem Bakhache, Olivier Deforges, and Mohamad Khalil. "Comparative Study of Three Steganographic Methods Using a Chaotic System and Their Universal Steganalysis Based on Three Feature Vectors." Entropy 21, no. 8 (July 30, 2019): 748. http://dx.doi.org/10.3390/e21080748.

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In this paper, we firstly study the security enhancement of three steganographic methods by using a proposed chaotic system. The first method, namely the Enhanced Edge Adaptive Image Steganography Based on LSB Matching Revisited (EEALSBMR), is present in the spatial domain. The two other methods, the Enhanced Discrete Cosine Transform (EDCT) and Enhanced Discrete Wavelet transform (EDWT), are present in the frequency domain. The chaotic system is extremely robust and consists of a strong chaotic generator and a 2-D Cat map. Its main role is to secure the content of a message in case a message

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Berrocal-Lobo, Marta, and Antonio Molina. "Ethylene Response Factor 1 Mediates Arabidopsis Resistance to the Soilborne Fungus Fusarium oxysporum." Molecular Plant-Microbe Interactions® 17, no. 7 (July 2004): 763–70. http://dx.doi.org/10.1094/mpmi.2004.17.7.763.

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Ethylene response factor 1 (ERF1) is a transcriptional factor from Arabidopsis thaliana that regulates plant resistance to the necrotrophic fungi Botrytis cinerea and Plectosphaerella cucumerina and whose overexpression enhances resistance to these fungi. Here, we show that ERF1 also mediates Arabidopsis resistance to the soilborne fungi Fusarium oxysporum sp. conglutinans and F. oxysporum f. sp. lycopersici, because its constitutive expression in Arabidopsis confers enhanced resistance to these pathogens. Expression of ERF1 was upregulated after inoculation with F. oxysporum f. sp. conglutina

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Kragt, J. J., J. M. Nielsen, F. AH van der Linden, B. MJ Uitdehaag, and C. H. Polman. "How similar are commonly combined criteria for EDSS progression in multiple sclerosis?" Multiple Sclerosis Journal 12, no. 6 (November 2006): 782–86. http://dx.doi.org/10.1177/1352458506070931.

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Introduction Measuring disease progression is an important aspect of multiple sclerosis (MS) clinical trials. Commonly applied disability endpoints include time to clinically meaningful Expanded Disability Status Scale (EDSS) change, or the number of patients in whom such a change has occurred. Typically, clinically meaningful EDSS change has been defined as a change of 1.0 point on Kurtzke’s EDSS in patients with an entry EDSS score of 5.5 or lower, or 0.5 point in patients with a higher EDSS score. Our goal was to evaluate whether these changes can be considered as similar. Therefore, we com

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Cho, Joong-Yang, Keun-Sik Hong, Ho Jin Kim, Su-Hyun Kim, Ju-Hong Min, Nam-Hee Kim, Suk-Won Ahn, et al. "Disability weight for each level of the Expanded Disability Status Scale in multiple sclerosis." Multiple Sclerosis Journal 20, no. 9 (January 7, 2014): 1217–23. http://dx.doi.org/10.1177/1352458513518259.

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Background: The Expanded Disability Status Scale (EDSS) is the most widely employed ordinal disability scale in multiple sclerosis (MS). However, how far apart the individual EDSS levels are along the disability spectrum has not been formally quantified. Objectives: The objective of this paper is to generate refined disability weights (DWs) for each of the ordinal EDSS levels. Methods: We performed the person trade-off (PTO) procedure to derive DWs of five representative EDSS categories (2, 4, 6, 7 and 9), and DWs of the remaining EDSS categories were assigned by linear interpolation. The modi

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Bove, Riley, Carolyn Bevan, Elizabeth Crabtree, Chao Zhao, Refujia Gomez, Priya Garcha, John Morrissey, et al. "Toward a low-cost, in-home, telemedicine-enabled assessment of disability in multiple sclerosis." Multiple Sclerosis Journal 25, no. 11 (August 24, 2018): 1526–34. http://dx.doi.org/10.1177/1352458518793527.

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Background: Remote assessment of neurological disability in people with multiple sclerosis (MS) could improve access to clinical care and efficiency of clinical research. Objective: To develop and validate a telemedicine-based MS disability examination that does not require an in-home examiner. Methods: Adults with MS were recruited after a standardized in-person Expanded Disability Status Scale (EDSS) evaluation, and within 1 week underwent a blinded televideo-enabled EDSS examination with a different clinician. EDSS and tele-EDSS scores were compared. Results: Overall, 41 adults participated

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Saccà, Francesco, Teresa Costabile, Antonio Carotenuto, Roberta Lanzillo, Marcello Moccia, Chiara Pane, Cinzia Valeria Russo, et al. "The EDSS integration with the Brief International Cognitive Assessment for Multiple Sclerosis and orientation tests." Multiple Sclerosis Journal 23, no. 9 (November 3, 2016): 1289–96. http://dx.doi.org/10.1177/1352458516677592.

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Objective: Despite cognitive tests have been validated in multiple sclerosis (MS), a neuropsychological evaluation is not implemented in the Expanded Disability Status Scale (EDSS) scoring. Methods: We used the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) and orientation tests (OTs) to measure the cerebral functional system (CFS) score and to evaluate its impact on the EDSS. We compared EDSS calculated as usual (Native-EDSS) and after the use of the BICAMS and OT (NPS-EDSS). Results: We tested 604 MS patients with BICAMS, OTs, and EDSS. In all, 384 patients (63.6%)

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Cheng, E. M., R. D. Hays, L. W. Myers, G. W. Ellison, M. Beckstrand, and B. G. Vickrey. "Factors related to agreement between self-reported and conventional Expanded Disability Status Scale (EDSS) scores." Multiple Sclerosis Journal 7, no. 6 (December 2001): 405–10. http://dx.doi.org/10.1177/135245850100700610.

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Background: Although the Expanded Disability Status Scale (EDSS) remains a widely used scale for evaluating impairments in people with multiple sclerosis (MS), EDSS assessments are infeasible in certain situations. A self-administered version of the EDSS would be potentially usefulif it yielded similar results as the conventional physician-based version. Methods: We developed a self-administered patient questionnaire to obtain ratings of neurologic impairments, and developed algorithms to estimate EDSS scores. We mailed the questionnaires to all new consecutive patients scheduled to be seen at

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Bowen, James, Laura Gibbons, Ann Gianas, and George H. Kraft. "Self-administered Expanded Disability Status Scale with functional system scores correlates well with a physician-administered test." Multiple Sclerosis Journal 7, no. 3 (June 2001): 201–6. http://dx.doi.org/10.1177/135245850100700311.

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Background: Patient-administered measures are needed to assess disability cost-effectively in large epidemiological studies. Setting: An outpatient clinic in a large multiple sclerosis center. Methods: A self-administered EDSS questionnaire was developed (EDSS-S). Consecutive patients with clinically definite multiple sclerosis completed the EDSS-S (n=95). During the same visit, a physician completed an EDSS (EDSS-P). Scores below 4.0 were determined using functional system (FS) scores. Scores above 4.0 were calculated by two methods, using gait alone and using gait and functional system score

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Wang, Xin, Hiromichi Tanaka, Masanori Baba, and Yung-chi Cheng. "Retention of Metabolites of 2′,3′-Didehydro-3′-Deoxy-4′-Ethynylthymidine, a Novel Anti-Human Immunodeficiency Virus Type 1 Thymidine Analog, in Cells." Antimicrobial Agents and Chemotherapy 53, no. 8 (May 26, 2009): 3317–24. http://dx.doi.org/10.1128/aac.00302-09.

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ABSTRACT 2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine (4′-Ed4T), a novel thymidine analog, has more potent anti-human immunodeficiency virus type 1 (HIV-1) activity than its progenitor, stavudine (d4T). The profile of the intracellular metabolites of 4′-Ed4T was qualitatively similar to that of zidovudine (AZT) but not to that of d4T, while after drug removal it showed more persistent anti-HIV activity than AZT or d4T in cell culture. When CEM cells were exposed to various concentrations of 4′-Ed4T, 4′-Ed4T was efficiently taken up by the cells and was readily phosphorylated to 4′-Ed4T monopho

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Wang, Jun, Shulan Li, and Bingshu He. "Chinese physicians’ attitudes toward eco-directed sustainable prescribing from the perspective of ecopharmacovigilance: a cross-sectional study." BMJ Open 10, no. 6 (June 2020): e035502. http://dx.doi.org/10.1136/bmjopen-2019-035502.

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IntroductionEco-directed sustainable prescribing (EDSP) is an effective upstream way to reduce the environmental footprints of active pharmaceutical ingredients (APIs), a kind of emerging contaminants, from the patients’ excretion. EDSP is one of the key steps in the programme of ecopharmacovigilance (EPV), a drug administration route on API pollution.ObjectiveTo assess the attitudes of physicians prescribing medicines regarding EDSP from the perspective of EPV.DesignA cross-sectional study conducted from March 2019 to June 2019.Setting5 government general hospitals in Hubei province, China.Pa

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Ravnborg, M., M. Blinkenberg, F. Sellebjerg, M. Ballegaard, S. Helweg Larsen, and P. Soelberg Sørensen. "Responsiveness of the Multiple Sclerosis Impairment Scale in comparison with the Expanded Disability Status Scale." Multiple Sclerosis Journal 11, no. 1 (February 2005): 81–84. http://dx.doi.org/10.1191/1352458505ms1120oa.

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The Multiple Sclerosis Impairment Scale (MSIS) is a measure of accumulated deficits assessed by means of a standard neurological examination. We compared the responsiveness of the MSIS with that of the Expanded Disability Status Scale (EDSS). We reviewed 4300 records collected systematically from 1995 to 2003 and identified 534 patients who had clinically definite multiple sclerosis and had had at least two clinical assessments with a time interval of 2-5 years. The rate of deterioration was significantly higher on the MSIS than on the EDSS. The annualized change in EDSS exhibited a maximum at

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Markowitz, Clyde E., Mary D. Hughes, Daniel D. Mikol, Lisa Shi, MerriKay Oleen-Burkey, and Douglas R. Denney. "Expanded Disability Status Scale Calculator for Handheld Personal Digital Assistant: Reliability Study." International Journal of MS Care 10, no. 2 (January 1, 2008): 33–39. http://dx.doi.org/10.7224/1537-2073-10.2.33.

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Through a standard neurological examination, the Expanded Disability Status Scale (EDSS) score is traditionally determined by a pen-and-paper method. The objectives of this study were to compare the interrater/method reliability of EDSS scores obtained through the pen-and-paper method with those obtained with the EDSS Calculator, evaluate test-retest reliability of the EDSS Calculator, and examine the validity of EDSS Calculator scores through correlation with the Ambulation Index (AI). During a single office visit, 62 subjects with multiple sclerosis (MS) from six study centers had disability

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Miller, Aaron, Vincent Spada, Dorothy Beerkircher, and Rivka Riven Kreitman. "Long-term (up to 22 years), open-label, compassionate-use study of glatiramer acetate in relapsing—remitting multiple sclerosis." Multiple Sclerosis Journal 14, no. 4 (January 21, 2008): 494–99. http://dx.doi.org/10.1177/1352458507085029.

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To evaluate the safety and efficacy of long-term glatiramer acetate (GA) therapy, 46 patients with relapsing—remitting multiple sclerosis (RRMS) were treated for up to 22 years in an ongoing, open-label study. Kurtzke expanded disability status scale (EDSS) was measured every six months, relapses were reported at occurrence and patients self-reported adverse events (AEs). At GA initiation, disease durations ranged from 0—20 years (median 6.0 years) and at data cut-off (October 2004), GA therapy duration ranged from 1—22 years (median 12.0 years). Mean EDSS score increased 0.9 ± 1.9 from the pr

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Patwardhan, M. B., D. B. Matchar, G. P. Samsa, D. C. McCrory, R. G. Williams, and T. T. Li. "Cost of multiple sclerosis by level of disability: a review of literature." Multiple Sclerosis Journal 11, no. 2 (April 2005): 232–39. http://dx.doi.org/10.1191/1352458505ms1137oa.

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We performed a review of the economic literature to identify what is known about the relationship between Expanded Disability Status Scale (EDSS) categories and cost of multiple sclerosis (MS). We sought cohort studies of patients with multiple sclerosis that described the costs attributed to each EDSS score and utilized specific inclusion criteria for the selection of 10 studies. We found that both direct and indirect costs rise continuously with increasing EDSS category, and this rise is qualitatively exponential. The rise in indirect costs appears at lower EDSS scores. The cost of a relapse

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Zhang, J., E. Waubant, G. Cutter, JS Wolinsky, and D. Leppert. "Composite end points to assess delay of disability progression by MS treatments." Multiple Sclerosis Journal 20, no. 11 (March 27, 2014): 1494–501. http://dx.doi.org/10.1177/1352458514527180.

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Background: The Expanded Disability Status Scale (EDSS) has low sensitivity and reliability for detecting sustained disability progression (SDP) in multiple sclerosis (MS) trials. Objective: This study evaluated composite disability end points as alternatives to EDSS alone. Methods: SDP rates were determined using 96-week data from the Olympus trial (rituximab in patients with primary progressive MS). SDP was analyzed using composite disability end points: SDP in EDSS, timed 25-foot walk test (T25FWT), or 9-hole peg test (9HPT) (composite A); SDP in T25FWT or 9HPT (composite B); SDP in EDSS an

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Kaufmann, Marco, Claude Vaney, Laura Barin, Xinglu Liu, and Viktor von Wyl. "Long-term worsening of different body functions in persons with progressive multiple sclerosis." Multiple Sclerosis Journal - Experimental, Translational and Clinical 6, no. 4 (October 2020): 205521732096451. http://dx.doi.org/10.1177/2055217320964514.

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Background It is unclear whether EDSS is responsive to disability worsening in advanced MS. Objective To explore the dynamics of disability worsening in persons with advanced-stage MS (EDSS ≥5.5) using three disability worsening definitions (EDSS, Rivermead Mobility Index (RMI), 9-Hole Peg Test (9-HPT)). Methods EDSS-, RMI- and 9-HPT-based disability worsening were assessed over a minimum of two years in a cohort of 286 persons with advanced MS attending inpatient rehabilitation using Kaplan-Meier Curves and multivariable Cox regression. Furthermore, the correspondence between EDSS-, RMI- and

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Rojas, Juan Ignacio, Liliana Patrucco, Cristina Besada, Laura Bengolea, and Edgardo Cristiano. "Brain atrophy at onset and physical disability in multiple sclerosis." Arquivos de Neuro-Psiquiatria 70, no. 10 (October 2012): 765–68. http://dx.doi.org/10.1590/s0004-282x2012001000003.

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The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS: MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categorized in three groups, EDSS=0, EDSS=1 and 2.5 and EDSS>2.5, and used as disability measure. RESULTS: Twenty-six patients were included. Mean atrophy during the first year in patients that reached an EDSS≥3 was -0.

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Alonso, Ricardo N., Maria B. Eizaguirre, Berenice Silva, Maria C. Pita, Cecilia Yastremiz, Sandra Vanotti, Fernando Cáceres, and Orlando Garcea. "Brain Function Assessment of Patients with Multiple Sclerosis in the Expanded Disability Status Scale." International Journal of MS Care 22, no. 1 (January 1, 2020): 31–35. http://dx.doi.org/10.7224/1537-2073.2018-084.

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Abstract Background: There is no consensus regarding assessment of the brain function functional system (FS) of the Expanded Disability Status Scale (EDSS) in patients with multiple sclerosis (MS). We sought to describe brain function FS assessment criteria used by Argentinian neurologists and, based on the results, propose redefined brain function FS criteria. Methods: A structured survey was conducted of 113 Argentinian neurologists. Considering the survey results, we decided to redefine the brain function FS scoring using the Brief International Cognitive Assessment for MS (BICAMS) battery.

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Dujmovic, Irena, Simon Demetz, Alban Millonig, and Florian Deisenhammer. "The effect of fatigability on expanded disability status scale components in multiple sclerosis." Srpski arhiv za celokupno lekarstvo 144, no. 5-6 (2016): 262–65. http://dx.doi.org/10.2298/sarh1606262d.

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Introduction. The Expanded Disability Status Scale (EDSS) is the most widely used disability measure in multiple sclerosis (MS). The effect of fatigability on EDSS components has been underreported to date. Objective We investigated daytime variability in EDSS score and EDSS components - functional scores (FS) and walking distance (WD) up to 500 m, in MS patients who underwent a standardized fatiguing exercise. Methods. Twenty-four patients with relapsing-remitting MS (n = 7), secondary-progressive MS (n = 8) and primary-progressive MS (n = 9) were included. Exclusion criteria were as follows:

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Ysrraelit, Celica, Fernando Caceres, Andres Villa, Marcela Parada Marcilla, Jorge Blanche, Marcos Burgos, Ignacio Casas Parera, et al. "ENCOMS: Argentinian survey in cost of illness and unmet needs in multiple sclerosis." Arquivos de Neuro-Psiquiatria 72, no. 5 (May 2014): 337–43. http://dx.doi.org/10.1590/0004-282x20140016.

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The objective of the study was to assess the cost of multiple sclerosis (MS) patients in Argentina categorized by disease severity using a societal perspective.Method:Cross-sectional study including MS patients from 21 MS centers in 12 cities of Argentina. Patients were stratified by disease severity using the expanded disability status scale (EDSS) (group 1 with EDSS score between 0 and 3; group 2 with EDSS >3 and <7; group 3 with EDSS ≥7). Direct and indirect costs were analyzed for the second quarter of 2012 from public sources and converted to US Dollars.Results:266 patients were inc

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Garcia-Hernandez, Carlos, Alberto Fernández, and Francesc Serratosa. "Learning the Edit Costs of Graph Edit Distance Applied to Ligand-Based Virtual Screening." Current Topics in Medicinal Chemistry 20, no. 18 (August 24, 2020): 1582–92. http://dx.doi.org/10.2174/1568026620666200603122000.

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Background: Graph edit distance is a methodology used to solve error-tolerant graph matching. This methodology estimates a distance between two graphs by determining the minimum number of modifications required to transform one graph into the other. These modifications, known as edit operations, have an edit cost associated that has to be determined depending on the problem. Objective: This study focuses on the use of optimization techniques in order to learn the edit costs used when comparing graphs by means of the graph edit distance. Methods: Graphs represent reduced structural representati

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Ford, C. C., K. P. Johnson, R. P. Lisak, H. S. Panitch, G. Shifroni, and J. S. Wolinsky. "A prospective open-label study of glatiramer acetate: over a decade of continuous use in multiple sclerosis patients." Multiple Sclerosis Journal 12, no. 3 (June 2006): 309–20. http://dx.doi.org/10.1191/135248506ms1318oa.

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A decade of continuous glatiramer acetate (GA) use by relapsing remitting multiple sclerosis (RRMS) patients was evaluated in this ongoing, prospective study, and the neurological status of ‘Withdrawn’ patients was assessed at a 10-year long-term follow-up (LTFU) visit. Modified intention-to-treat (mITT, n=232) patients received ≥ 1 GA dose since 1991; ‘Ongoing’ patients ( n=108) continued in November 2003. Of 124 patients, 50 Withdrawn patients returned for LTFU. Patients were evaluated every six months (EDSS). Mean GA exposure was 6.99, 10.1 and 4.26 years for mITT, Ongoing, and Withdrawn/LT

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Chitnis, Tanuja, Greg Aaen, Anita Belman, Leslie Benson, Mark Gorman, Manu S. Goyal, Jennifer S. Graves, et al. "Improved relapse recovery in paediatric compared to adult multiple sclerosis." Brain 143, no. 9 (August 18, 2020): 2733–41. http://dx.doi.org/10.1093/brain/awaa199.

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Abstract Incomplete relapse recovery contributes to disability accrual and earlier onset of secondary progressive multiple sclerosis. We sought to investigate the effect of age on relapse recovery. We identified patients with multiple sclerosis from two longitudinal prospective studies, with an Expanded Disability Status Scale (EDSS) score within 30 days after onset of an attack, and follow-up EDSS 6 months after attack. Adult patients with multiple sclerosis (n = 632) were identified from the Comprehensive Longitudinal Investigations in Multiple Sclerosis at Brigham study (CLIMB), and paediat

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Skjerbæk, Anders Guldhammer, Finn Boesen, Thor Petersen, Peter Vestergaard Rasmussen, Egon Stenager, Michael Nørgaard, Peter Feys, Marie Louise Kjeldgaard-Jørgensen, Lars Grøndahl Hvid, and Ulrik Dalgas. "Can we trust self-reported walking distance when determining EDSS scores in patients with multiple sclerosis? The Danish MS hospitals rehabilitation study." Multiple Sclerosis Journal 25, no. 12 (August 20, 2018): 1653–60. http://dx.doi.org/10.1177/1352458518795416.

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Background: In multiple sclerosis (MS), the Expanded Disability Status Scale (EDSS) reflects disease severity. Although parts of the EDSS are dependent on actual walking distance, self-reported statements are often applied. Objectives: The purpose of the present study was, therefore, to compare self-reported walking distance to actual walking distance to outline how this influences EDSS scoring. Methods: MS patients with EDSS 4.0–7.5 ( n = 273) were included from the Danish MS hospitals rehabilitation study ( n = 427). All patients subjectively classified their maximal walking distance accordi

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Bosma, Libertje VAE, Jolijn J. Kragt, Dirk L. Knol, Chris H. Polman, and Bernard MJ Uitdehaag. "Clinical scales in progressive MS: predicting long-term disability." Multiple Sclerosis Journal 18, no. 3 (August 25, 2011): 345–50. http://dx.doi.org/10.1177/1352458511419880.

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Background: To determine which short-term changes on clinical scales including the Expanded Disability Status Scale (EDSS), Timed 25-Foot Walk (T25FW), 9-Hole Peg test (9HPT) and Guy’s Neurological Disability Scale (GNDS) are most predictive of long-term outcome of disability as rated by the EDSS in progressive multiple sclerosis (MS). Methods: From a longitudinal database, all progressive patients, both primary (PP) and secondary (SP), were selected on the basis of at least two complete examinations being available within a time interval of 1–2 years (short-term change). All patients who fulf

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Hyyrö, Heikki, and Shunsuke Inenaga. "Dynamic RLE-Compressed Edit Distance Tables Under General Weighted Cost Functions." International Journal of Foundations of Computer Science 29, no. 04 (June 2018): 623–45. http://dx.doi.org/10.1142/s0129054118410083.

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Kim and Park [A dynamic edit distance table, J. Disc. Algo., 2:302–312, 2004] proposed a method (KP) based on a “dynamic edit distance table” that allows one to efficiently maintain unit cost edit distance information between two strings [Formula: see text] of length [Formula: see text] and [Formula: see text] of length [Formula: see text] when the strings can be modified by single-character edits to their left or right ends. This type of computation is useful e.g. in cyclic string comparison. KP uses linear time, [Formula: see text], to update the distance representation after each single edi

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Cohen, Y. C., S. Hassin-Baer, L. Olmer, R. Barishev, Y. Goldhammer, L. Freedman, and B. Mozes. "MS-CANE: a computer-aided instrument for neurological evaluation of patients with multiple sclerosis: enhanced reliability of expanded disability status scale (EDSS) assessment." Multiple Sclerosis Journal 6, no. 5 (October 2000): 355–61. http://dx.doi.org/10.1177/135245850000600511.

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Kurtzke's EDSS remains the most widely-used measure for clinical evaluation of MS patients. However, several studies have demonstrated the limited reliability of this tool. We introduce a computerized instrument, MS-CANE (Multiple Sclerosis Computer-Aided Neurological Examination), for clinical evaluation and follow up of patients with multiple sclerosis (MS) and to compare its reliability to that of conventional Expanded Disability Status Scale (EDSS) assessment. We developed a computerized interactive instrument, based on the following principles: structured gathering of neurological finding

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Zhang, Jiameng, Emmanuelle Waubant, Gary Cutter, Jerry S. Wolinsky, and Robert Glanzman. "EDSS variability before randomization may limit treatment discovery in primary progressive MS." Multiple Sclerosis Journal 19, no. 6 (October 1, 2012): 775–81. http://dx.doi.org/10.1177/1352458512459685.

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Background: Baseline Expanded Disability Status Scale (EDSS) is usually based on a single measurement. Here we evaluated whether using a baseline EDSS derived from two pre-treatment measurements improves the detection of progression events and the ability to demonstrate a therapeutic effect in delaying MS disability progression. Methods: Real data from OLYMPUS, a phase II/III randomized, placebo-controlled trial of rituximab in patients with primary progressive multiple sclerosis (PPMS), as well as simulated data were analyzed. Several definitions of baseline EDSS were used to capture sustaine

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Lavorgna, L., S. Bonavita, D. Ippolito, R. Lanzillo, G. Salemi, F. Patti, P. Valentino, et al. "Clinical and magnetic resonance imaging predictors of disease progression in multiple sclerosis: a nine-year follow-up study." Multiple Sclerosis Journal 20, no. 2 (July 9, 2013): 220–26. http://dx.doi.org/10.1177/1352458513494958.

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Objective: The objective of this paper is to identify clinical or magnetic resonance imaging (MRI) predictors of long-term clinical progression in a large cohort of multiple sclerosis (MS) patients. Methods: A total of 241 relapsing–remitting (RR) MS patients were included in a nine-year follow-up (FU) study. The reference MRIs were acquired at baseline (BL) as part of a multicenter, cross-sectional, clinical-MRI study. Volumetric MRI metrics were measured by a fully automated, operator-independent, multi-parametric segmentation method. Clinical progression was evaluated as defined by: convers

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Freilich, Jonatan, Ali Manouchehrinia, Mark Trusheim, Lynn G. Baird, Sophie Desbiens, Ernst Berndt, and Jan Hillert. "Characterization of annual disease progression of multiple sclerosis patients: A population-based study." Multiple Sclerosis Journal 24, no. 6 (May 8, 2017): 786–94. http://dx.doi.org/10.1177/1352458517706252.

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Background: Previous research characterizing factors influencing multiple sclerosis (MS) disease progression has typically been based on time to disease milestones (Kaplan–Meier, Cox hazard regression, etc.). A limitation of these methods is the handling of the often large groups of patients not reaching the milestone. Objective: To characterize clinical factors influencing MS disease progression as annual transitions from each Expanded Disability Status Scale (EDSS). Method: The annual progression of 11,964 patients from the Swedish MS Registry was analysed with 10 multinomial logistic regres

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Koch, Marcus W., Jop Mostert, Bernard Uitdehaag, and Gary Cutter. "Clinical outcome measures in SPMS trials: An analysis of the IMPACT and ASCEND original trial data sets." Multiple Sclerosis Journal 26, no. 12 (September 13, 2019): 1540–49. http://dx.doi.org/10.1177/1352458519876701.

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Background: Still too little is known about the natural history of clinical outcome measures beyond the Expanded Disability Status Scale (EDSS), such as the timed 25-foot walk (T25FW) and nine-hole peg test (9HPT) in secondary progressive multiple sclerosis (SPMS). Objective: To describe progression on the EDSS, T25FW, 9HPT, and their combinations. To investigate the association of the baseline characteristics age, sex, EDSS, T25FW, gadolinium-enhancing lesions, and relapse activity with EDSS and T25FW progression. Methods: Using original trial data from the placebo arms of the IMPACT and ASCE

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Grima, D. T., G. W. Torrance, G. Francis, G. Rice, A. J. Rosner, and L. Lafortune. "Cost and health related quality of life consequences of multiple sclerosis." Multiple Sclerosis Journal 6, no. 2 (April 2000): 91–98. http://dx.doi.org/10.1177/135245850000600207.

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Objectives: To (i) quantify the cost of multiple sclerosis (MS) to the Canadian health care system and society; (ii) measure health utility in MS patients, and (iii) examine the influence of disability on patient utility and health care costs.Materials and methods: A comprehensive patient survey and chart review of relapsing MS patient in remission, relapse and recalling a relapse.Results: Annual remission costs increased with EDSS level ($7596 at EDSS 1, $33 206 at EDSS 6). At all EDSS levels the largest costs were due to inability to work, which increased with EDSS. The average relapse cost

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Prados, Nicolás, Rocío Quiroga, Cinzia Caligara, Myriam Ruiz, Víctor Blasco, Antonio Pellicer, and Manuel Fernández-Sánchez. "Elective single versus double embryo transfer: live birth outcome and patient acceptance in a prospective randomised trial." Reproduction, Fertility and Development 27, no. 5 (2015): 794. http://dx.doi.org/10.1071/rd13412.

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The purpose of this study was to determine which strategy of embryo transfer has a better trade-off in live birth delivery rate versus multiple pregnancy considering patient acceptance: elective single embryo transfer (eSET) or elective double embryo transfer (eDET). In all, 199 women <38 years of age undergoing their first IVF treatment in a private centre were included in a prospective open-label randomised controlled trial. Patients were randomised into four groups: (1) eSET on Day 3; (2) eSET on Day 5; (3) eDET on Day 3; and (4) eDET on Day 5. Per patient, main analysis included accepta

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Pan, Yanhui, Faqiong Zhao, and Baizhao Zeng. "Electrochemical sensors of octylphenol based on molecularly imprinted poly(3,4-ethylenedioxythiophene) and poly(3,4-ethylenedioxythiophene–gold nanoparticles)." RSC Advances 5, no. 71 (2015): 57671–77. http://dx.doi.org/10.1039/c5ra08094k.

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Two molecularly imprinted electrochemical sensors are fabricated by using EDOT and EDOT–AuNPs as monomers, respectively. The sensors show good analytical performance for OP sensing. Note: graphene nanoribbons (GNRs), 3,4-ethylenedioxythiophene (EDOT), 4-tert-octyl-phenol (OP).

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Nagane, Samadhan, Peter Sitarik, Yuhang Wu, Quintin Baugh, Shrirang Chhatre, Junghyun Lee, and David C. Martin. "Functionalized Polythiophene Copolymers for Electronic Biomedical Devices." MRS Advances 5, no. 18-19 (2020): 943–56. http://dx.doi.org/10.1557/adv.2020.3.

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ABSTRACTWe continue to investigate the design, synthesis, and characterization of electrically and ionically active conjugated polythiophene copolymers for integrating a variety of biomedical devices with living tissue. This paper will describe some of our most recent results, including the development of several new monomers that can tailor the surface chemistry, adhesion, and biointegration of these materials with neural cells. Our efforts have focused on copolymers of 3,4 ethylenedioxythiophene (EDOT), functionalized variants of EDOT (including EDOT-acid and the trifunctional EPh), and dopa

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Lapin, Dmitry, Deepak D. Bhandari, and Jane E. Parker. "Origins and Immunity Networking Functions of EDS1 Family Proteins." Annual Review of Phytopathology 58, no. 1 (August 25, 2020): 253–76. http://dx.doi.org/10.1146/annurev-phyto-010820-012840.

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The EDS1 family of structurally unique lipase-like proteins EDS1, SAG101, and PAD4 evolved in seed plants, on top of existing phytohormone and nucleotide-binding–leucine-rich-repeat (NLR) networks, to regulate immunity pathways against host-adapted biotrophic pathogens. Exclusive heterodimers between EDS1 and SAG101 or PAD4 create essential surfaces for resistance signaling. Phylogenomic information, together with functional studies in Arabidopsis and tobacco, identify a coevolved module between the EDS1–SAG101 heterodimer and coiled-coil (CC) HET-S and LOP-B (CCHELO) domain helper NLRs that i

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