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1
Francisco, Diez de Velasco. "Prisciliano y Eduardo Alfonso." Cultura masónica XIII, no. 45 (2021): 47–59. https://doi.org/10.5281/zenodo.4708018.
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Eduardo Alfonso Hemán (1894-1991) es muy conocido como pionero del naturismo en España, pero de entre los múltiples temas de estudio que cultivó en su muy larga vida, resulta destacable el que nombra como historia comparada de las religiones. Se repasará la figura de Prisciliano en esa obra y la autoidentificación con ese nombre por parte del autor analizado.
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Fernández Ruiz, Jorge. "LIMINAR." Revista de la Facultad de Derecho de México 67, no. 268 (2017): 11. http://dx.doi.org/10.22201/fder.24488933e.2017.268.60980.
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Durante más de medio siglo la Revista de la Facultad de<br />Derecho de México fue escaparate del producto de la investigación científica realizada por sus profesores en afán de contribuir al avance y perfeccionamiento de la ciencia jurídica, de ello dan constancia espléndidos artículos de los juristas Eduardo García Máynez, Niceto Alcalá-Zamora, Alfonso García Robles, Luis Recasens Siches, Eduardo Pallares Portillo, Gabino Fraga Magaña, Alfonso Noriega Cantú, Andrés Serra Rojas, Antonio Martínez Báez, Raúl Cervantes Ahumada, Mario de la Cueva, Rafael Rojina Villegas, Alberto Vázquez del Mercado, Martha Chávez Padrón, Lucio Mendieta y Núñez, Aurora Arnaiz Amigo, Ignacio Burgoa Orihuela, Héctor González Uribe, Jorge Mario Magallón Ibarra, Héctor Fix-Zamudio, Sergio García Ramírez, Jorge Carpizo Mc- Gregor, Rolando Tamayo y Salmorán, Sara Bialostosky, Diego Valadés Ríos, Olga Islas de González Mariscal, Eduardo López Betancourt y Olga Sánchez Cordero, por citar solo algunos de sus autores.
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Castillón, Eduardo Estrada, José Ángel Villarreal Quintanilla, and Alfonso Delgado Salinas. "A new section of Astragalus (Fabaceae: Galegeae) from Mexico." Phytotaxa 545, no. 1 (2022): 79–86. https://doi.org/10.11646/phytotaxa.545.1.6.
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Castillón, Eduardo Estrada, Quintanilla, José Ángel Villarreal, Salinas, Alfonso Delgado- (2022): A new section of Astragalus (Fabaceae: Galegeae) from Mexico. Phytotaxa 545 (1): 79-86, DOI: 10.11646/phytotaxa.545.1.6, URL: http://dx.doi.org/10.11646/phytotaxa.545.1.6
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Rodriguez Lajusticia, Francisco Saulo. "relación de Alfonso III de Aragón (1285-1291) con la monarquía inglesa." Aragón en la Edad Media, no. 30 (June 1, 2020): 325–49. http://dx.doi.org/10.26754/ojs_aem/aem.2019304431.
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Resumen: La relación entre Aragón e Inglaterra durante el reinado de Alfonso III de Aragón (1285-1291), también conocido por la historiografía como «el Franco» o «el Liberal», fue muy cercana y no solo con Eduardo I, sino también con su esposa la reina Leonor de Castilla. Como fruto de esa alianza se firmaron los tratados de Olorón (1287) y Canfranc (1288) en el seno de unas turbulentas relaciones entre los reinos europeos. Aunque Thomas Rymer transcribió la mayoría de los documentos de esta relación entre los siglos xvii y xviii, no incluyó todos los diplomas existentes y se equivocó en la datación de algunos de ellos. Este artículo completa el trabajo de Rymer y analiza qué temas se trataron entre los reyes de Aragón e Inglaterra durante sus muy habituales contactos. Palabras clave: Alfonso III de Aragón, Eduardo I de Inglaterra, Leonor de Castilla, relaciones internacionales, siglo XIII. Abstract: The relationship between Aragon and England during the reign of Alfonso III of Aragon (1285-1291), also known by historians as «the Franco» or «the Liberal», was very close and not only with Eduardo I, but also with his wife Eleanor of Castile. As a result of this alliance, the treaties of Oloron-Sainte-Marie (1287) and Canfranc (1288) were signed within a lot of turbulent relations between the European kingdoms. Although Thomas Rymer transcribed the most of the documents about this relationship between the 17th and 18th centuries, he didn’t include all the existing documents and he was wrong in the dating of some of them. This work completes Rymer's study and analyzes which topics were discussed between the kings of Aragon and England during their very regular contacts. Key words: Alfonso III of Aragon, Edward I of England, Eleanor of Castile, international relations, 13th century.
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Castillón, Eduardo Estrada, José Ángel Villarreal Quintanilla, Alfonso Delgado-Salinas, and Jon P. Rebman. "The genus Astragalus (Leguminosae: Papilionoideae: Galegeae) in Mexico." Phytotaxa 586, no. 1 (2023): 1921–35. https://doi.org/10.11646/phytotaxa.586.1.1.
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Castillón, Eduardo Estrada, Quintanilla, José Ángel Villarreal, Delgado-Salinas, Alfonso, Rebman, Jon P. (2023): The genus Astragalus (Leguminosae: Papilionoideae: Galegeae) in Mexico. Phytotaxa 586 (1): 1921-1935, DOI: 10.11646/phytotaxa.586.1.1, URL: http://dx.doi.org/10.11646/phytotaxa.586.1.1
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Montero, Santiago. "Alfonso Álvarez-Ossorio Rivas – Eduardo Ferrer Albelda – Álvaro Delgado Pereira (coords.), Guerra y Paz. Las religiones ante los conflictos bélicos en la Antigüedad (=SPAL Monografías XXIII), Sevilla, Editorial Universidad de Sevilla–Servicio de asistenci." Gerión. Revista de Historia Antigua 38, no. 1 (2020): 404–6. http://dx.doi.org/10.5209/geri.68625.
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Reseña del libro de Alfonso Álvarez-Ossorio Rivas – Eduardo Ferrer Albelda – Álvaro Delgado Pereira (coords.), Guerra y Paz. Las religiones ante los conflictos bélicos en la Antigüedad (=SPAL Monografías XXIII), Sevilla, Editorial Universidad de Sevilla–Servicio de asistencia religiosa de la Universidad de Sevilla, 2016, 237 pp. [ISBN: 978-84-472-1854-7].
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Becerra, Jesus Duenas. "Doctor Eduardo Bernabé Ordaz: An Exemplary Father for Cuban Psychologists." Psychology & Psychological Research International Journal 8, no. 3 (2023): 1–2. http://dx.doi.org/10.23880/pprij-16000352.
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There are figures that the passage of time is blurring from the memory archive of peoples. Others, on the contrary, take root with such force that they remain registered forever in the poetic memory of humanity». That is the case of Dr. Eduardo Bernabé Ordaz Ducungé (1921-2006), described by professor and senior researcher Raúl Fuillerat Alfonso (1950-2015) as the «intellectual and spiritual father of island psychologists» This chronicle evokes the sacred memory of the founding director of the Havana Psychiatric Hospital, on the occasion of Parents’ Day, in the year of the 101st anniversary of his birth.
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Botti, Alfonso, Eduardo González Calleja, and Teresa María Ortega López. "Regímenes fascistas y autoritarios: usos de la historia." Ayer. Revista de Historia Contemporánea 124, no. 4 (2021): 349–74. http://dx.doi.org/10.55509/ayer/124-2021-14.
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En este debate, los historiadores Alfonso Botti, de la Universidad de Modena-Reggio Emilia; Eduardo González Calleja, de la Universidad Carlos III de Madrid, y Teresa M. Ortega, de la Universidad de Granada, reflexionan sobre el auge de la nueva derecha populista, sus eventuales causas y referentes históricos y las respuestas culturales, políticas e historiográficas que se han ido configurando al respecto.
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Cantavella Blasco, Juan. "La columna en verso: recuerdo y presencia de poetas y versificadores." Doxa Comunicación. Revista interdisciplinar de estudios de comunicación y ciencias sociales, no. 13 (2011): 67–88. http://dx.doi.org/10.31921/doxacom.n13a3.
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A veces, entre la uniformidad de las columnas periodísticas, surgen formas singulares que tienen sus cultivadores y sus seguidores. Ocurre con la columna en verso, de la que encontramos muestras en el siglo XIX (Eduardo Marquina, José del Río Sáinz, Salvador M. Granés, Manuel del Palacio…) y en el XX (Luis de Tapia,Raimundo de los Reyes, Félix Antonio González, Jaime Campmany, Alfonso Ussía…). Aquí repasamos la historia de esta modalidad opinativa y las peculiaridades que estos autores aporta (sátira, humor y amenidad).
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Anduaga, Aitor. "Earthquakes, Damage, and Prediction: the Spanish Seismological Service, 1898-1930." Earth Sciences History 23, no. 2 (2004): 175–207. http://dx.doi.org/10.17704/eshi.23.2.f47560027108w202.
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The creation and development of the Servicio Sismológico Español (1906-1930) clearly illustrates the complexity of the organisation of seismological networks in Spain during the Restauración and the reign of Alfonso XIII. A unique combination of technical advances, seismological knowledge and the need for safety and seismic prediction gave rise to the emergence of both state and private observatories, an important aspect of the process of scientific modernisation after the Spanish-American war of 1898. This paper aims to show how the engineer Eduardo Mier y Miura (1858-1917) played a key role in the foundation of the Servicio, despite the fact that some of his decisions and contributions were highly criticised by the next generation of seismologists. Figures such as Vicente Inglada, José Galbis, and Alfonso Rey Pastor carried out a complete reorganisation of the Servicio. These events did not stem from the well-known regeneracionismo movement which took place at the turn of the century, but were rather the result of internal dynamics.
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López Azorín, Fernando. "Constitution and brief history of the College of Pharmacists of Cartagena and La Unión (1900-1904)." Anales de la Real Academia Nacional de Farmacia 90, no. 90(04) (2025): 471–88. https://doi.org/10.53519/analesranf.2024.90.04.04.
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On June 6, 1900, a Royal Order authorized the creation of a College of Physicians and another of Pharmacists for the towns of Cartagena and La Unión in the province of Murcia. The College of Pharmacists was established on September 1, 1900 with a Governing Board chaired by Eduardo Romero Germes, Gonzalo Robles Fernández as secretary, first member Antonio Rodríguez Comellas, second member Alfonso Carrión Inglés and treasurer José Díaz Benzal. Starting from the pharmacists of both towns in the last third of the 19th century, the history of the application for the College, the constitution process, the news about its operation and the cause of its dissolution on May 30, 1904 are reviewed. In addition to the list of registered pharmacists, the biography of the five members of its Governing Board is recalled and the constitution of the College is analyzed in relation to the cantonal uprising of 1873. Keywords: College of Pharmacists of Cartagena and La Unión; Medical-Pharmaceutical Academy of Cartagena; Government Board; Eduardo Romero Germes
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Caiceo Escudero, Jaime. "Filosofía franciscana en Chile: dos principales exponentes." Revista Guillermo de Ockham 17, no. 2 (2019): 81–90. http://dx.doi.org/10.21500/22563202.4365.
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La Orden Franciscana está presente en Chile desde 1553 y en este artículo se destacan dos principales filósofos: Alfonso Briceño Arias (1587-1668) y Eduardo Rosales Rojas (1906-1970). Al primero se le conoce como el Segundo Escoto, pues su pensamiento se inspira en el famoso beato inglés. El segundo se doctora en la Universidad Católica de Chile, en donde será académico de Teología Moral.
 El objeto de este artículo es desarrollar el pensamiento filosófico de ambos pensadores franciscanos chilenos. Este trabajo es fruto de una investigación más amplia acerca de la Filosofía Franciscana. Para realizarla se ha recurrido a la metodología histórica -revisando fuentes primarias y secundarias- y al análisis filosófico de los escritos de los pensadores.
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Amslinger, Sabine, and Kirsten Zeitler. "Asymmetric Organic Synthesis with Enzymes. Edited by Vicente Gotor, Ignacio Alfonso, and Eduardo García-Uridiales." ChemSusChem 1, no. 12 (2008): 1026–27. http://dx.doi.org/10.1002/cssc.200800148.
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Berglund, Per. "Asymmetric Organic Synthesis with Enzymes. Edited by Vicente Gotor, Ignacio Alfonso and Eduardo García-Urdiales." Angewandte Chemie International Edition 47, no. 35 (2008): 6514–15. http://dx.doi.org/10.1002/anie.200885614.
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Berglund, Per. "Asymmetric Organic Synthesis with Enzymes. Herausgegeben von Vincente Gotor, Ignacio Alfonso und Eduardo García-Urdiales." Angewandte Chemie 120, no. 35 (2008): 6614–15. http://dx.doi.org/10.1002/ange.200885614.
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Maraña, Félix, and Ana Urrutia Jordana. "Eduardo Ortega y Gasset: el amigo (casi) invisible de Unamuno en el destierro de París y Hendaya (1924-1930)." Cuadernos de la Cátedra Miguel de Unamuno, no. 52 (July 8, 2025): 147–81. https://doi.org/10.14201/ccmu202452147181.
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El destierro de Unamuno (1924-1930) comprende un trecho decisivo en su vida y en la de España, determinado por la dictadura de Primo de Rivera y el declive de la monarquía de Alfonso XIII. Tanto en París como en Hendaya, Unamuno recibió el apoyo intelectual y material de Eduardo Ortega y Gasset (1882-1965). Este periodista, político y jurista ayudó al escritor en su campaña política contra el Directorio y a resistir en el exilio. La casa de Ortega y Gasset en Hendaya fue para Unamuno el domicilio familiar del que carecía, y el lugar en el que se editó Hojas Libres (1927-1930), revista clandestina y extremadamente crítica contra el Directorio, que dirigía Ortega y en la que ambos fueron los principales colaboradores. Este clima afectivo le procuró a Unamuno asimismo la escritura de una parte fundamental de su obra poética.
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Navarro, Jesús Raúl. "Las independencias iberoamericanas en su laberinto. Controversias, cuestiones, interpretaciones." Revista de Historia Iberoamericana 4, no. 2 (2011): 141–44. http://dx.doi.org/10.3232/rhi.2011.v4.n2.08.
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Es reseña de: Las independencias iberoamericanas en su laberinto: Controversias, cuestiones, interpretaciones John H. Elliott, John Lynch, Tulio Halperin Donghi, Josep Fontana Lázaro, Jaime E. Rodríguez O., Eric Van Young, Carlos Marichal, Germán Carrera Damas, Brian Hamnett, Alberto Gil Novales, David Bushnell, Ana Ribeiro, Ana Frega Novales, Armando Martínez Garnica, Beatriz Bragoni, Enrique Ayala Mora, Carlos Contreras, Clement Thibaud, Oscar Almario García, Geneviève Verdo, João Paulo G. Pimenta, Jorge Daniel Gelman, Julio Sanchez Gomez, Marta Irurozqui Victoriano, Miquel Izard, Nidia R. Areces, Sara Emilia Mata de López, Tomás Straka, Víctor Peralta Ruiz, Alfonso Múnera, Mónica Quijada Mauriño, Xiomara Avendaño Rojas, Michael Zeuske, Juan Marchena Fernández, María Luisa Soux, Federica Morelli, Patricia Galeana de Valadés, Sajid Alfredo Herrera Mena, Véronique Hérbrad, Juan Andreo García, Eduardo Cavieres Figueroa, Ivana Frasquet Miguel; Manuel Chust Calero (ed. lit.) Universitat de València, Servei de Publicacions, 2010. ISBN 978-84-370-7900-4
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Benoit, Alexandre. "Le Corbusier y la construcción del espacio (visual) moderno en Brasil." A&P Continuidad 5, no. 8 (2018): 48–57. http://dx.doi.org/10.35305/23626097v5i8.103.
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Este texto procura demostrar cómo Le Corbusier, a través de los viajes de 1929 y 1936 a Río de Janeiro, no solo proporciona las bases de la arquitectura moderna en el país, sino que también problematiza la relación entre espacio construido y naturaleza. Frente a una realidad completamente distinta de aquella del Viejo Mundo, puesto que la naturaleza tropical se impone, el arquitecto franco-suizo se ve impulsado a jugar una partida entre afirmación-hombre y presencia-naturaleza. Tanto Lucio Costa como la primera generación de arquitectos modernos cariocas (Oscar Niemeyer, Alfonso Eduardo Reidy, Jorge Moreira, los hermanos Roberto, entre otros) realizan significativos aportes hacia interpretaciones originales que subvierten y amplían las categorías propuestas por Le Corbusier. Tal empeño –que desarrolla medios diversos de una fluidez entre adentro y afuera, edificio y paisaje– tiene al final una repercusión en la propia aprehensión visual del edificio con los elementos icónicos de ese paisaje: la selva tropical, el morro del Pan de azúcar y la Bahía de Guanabara.
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De Medicina de Colombia, Academia Nacional. "Recapitulación. Centenario de la Academia Nacional de Medicina en 1973." Medicina 45, no. 1 (2023): 13–30. http://dx.doi.org/10.56050/01205498.2214.
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Fragmento:
 En la ciudad de Bogotá a los 23 días del mes de agosto de 1973 se reunió en Sesión Solemne la Academia Nacional de Medicina en el Salón de Actos de la Academia Colombiana de la Lengua, para conmemorar el Primer Centenario de su Fundación (1873-1973).
 La Mesa Directiva estuvo integrada por el Señor Presidente de la República, Dr Misael Pastrana Borrero; los Académicos Juan Pablo Llinás, Presidente; Jorge Cavelier, Presidente Honorario; Mario Gaitán Yanguas, Vicepresidente; Julio Araújo Cuéllar, Secretario; Alberto Albornoz Plata, Tesorero y César A. Pantoja, Presidente del Comité Organizador del Centenario, acompañados por los Ministros de Salud Pública y Educación, Doctores José María Salazar Buchelli y Juan Jacobo Muñoz; El Gobernador de Cundinamarca, Doctor Alfonso Dávila Ortiz; el Alcalde Mayor de la ciudad doctor Aníbal Fernández de Soto; el Expresidente de la República Doctor Julio César Turbay Ayala; los doctores Eduardo Guzmán Esponda y Joaquín Piñeros Corpas, Presidente y Secretario Ejecutivo del Colegio Máximo de las Academias; el doctor Germán Zea Hernández y el doctor Armando Roa de Chile, Representante de la Asociación Latinoamericana de Academias Nacionales de Medicina (ALANAM).
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Fernández-Arata, Manuel. "Editorial." LIBERABIT. Revista Peruana de Psicología 28, no. 1 (2022): e601. http://dx.doi.org/10.24265/liberabit.2022.v28n1.01.
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Liberabit, Revista Peruana de Psicología, comparte con la comunidad académica nacional e internacional el presente volumen conformado por seis artículos de investigación, cuatro empíricos y dos teóricos.
 Iniciamos esta presentación con el trabajo realizado por Gutemberg de Sousa Lima Filho, Jéssica Gomes de Alcántara, Mateus Egilson da Silva Alves, Ludgleydson Fernandes de Araujo, Evair mendes da Silva Sousa, Igor Eduardo de Lima Bezerra y Maria Fernanda Lima Silva, realizan un estudio sobre las representaciones sociales de la vejez LGTB, considerando la comprensión social de la vejez, los estigmas sobre los géneros y las orientaciones sexuales y los cambios físicos y los obstáculos, reportando que las representaciones sociales están asociadas con las dificultades que existen para envejecer en sociedad y para discutir sobre la vejez LGTB, siendo estas mayores en las mujeres profesionales. Asimismo, presentamos el estudio realizado por Alfonso Elías-Risco y Gina Chávez-Ventura acerca de la eficacia de un programa biográfico profesional, que tiene como propósito disminuir las conductas sexuales de riesgo en hombres que tienen sexo con hombres, encontrando que el programa reduce las conductas sexuales de riesgo de los participantes, pero que en el caso de aquellos que padecen de una enfermedad de transmisión sexual, se presenta la disminución, pero sin extinguirse.
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Jesús, Miguel Delgado Del Aguila. "Panorama del teatro peruano contemporáneo. Entrevista a César Ernesto Arenas Ulloa." Argus-a. Artes & Humanidades XI, no. 42 (2021): 1–15. https://doi.org/10.5281/zenodo.6950918.
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Este trabajo expone la entrevista realizada al docente peruano y licenciado en Literatura, César Ernesto Arenas Ulloa, que fue desarrollada y transcrita por el investigador Jesús Miguel Delgado Del Aguila. Para abordar ese intercambio de conocimientos, se tomó como referente los estudios hechos acerca del teatro peruano contemporáneo. Asimismo, fue de utilidad reanudar la tesis Autonomía y especificidad de la obra dramática: una lectura semiológica de El sistema Solar de Mariana de Althaus para detectar los factores, los componentes, el contexto y algunas definiciones medulares, tales como la “dramaturgia del 900” y el “teatro del cambio de siglo” (acontecimientos que ocurren en el Perú). Para este propósito, el autor hizo una mención didáctica de los referentes teóricos principales que empleó, tales como Jiri Veltrusky, Anne Ubersfeld, Jorge Dubatti, Antonio Cornejo Polar, Jacques Lacan o Louis Althusser, así como aludió a dramaturgos que utilizó para sus análisis, como a Rafael Dumett, Alfonso Santistevan, César de María, Eduardo Adrianzén, Daniel Dillon, Patricia Biffi, entre otros.
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Martínez Peñín, Raquel. "Presentación. Evolución de los espacios urbanos y sus territorios en el noroeste de la Península Ibérica (II)." Estudios Humanísticos. Historia, no. 17 (December 15, 2020): 11. http://dx.doi.org/10.18002/ehh.i17.7650.
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El presente monográfico contiene una serie de investigaciones especializadas que, sin duda, contribuirán a ampliar sustancialmente el conocimiento científico que tenemos sobre determinadas realidades habitacionales y materiales del área septentrional de la Península Ibérica. Además, los sitios arqueológicos recogidos en este volumen responden a contextos tanto de carácter rural como urbano y con un amplio abanico cronológico que abarca realidades que van desde la Protohistoria hasta la Edad Media. Así pues, el primero de los trabajos de este número se inicia con el estudio realizado por Hugo Lozano Hermida, Eduardo Ramil Rego, José Manuel Caamaño Gesto y Sara Barbazán Domínguez titulado “Castreños y romanos en el occidente cantábrico: estado de la cuestión y algunas reflexiones”, centrado en el estudio de una serie de zonas arqueológicas emplazados en el área geográfica sita entre Punta de Estaca de Bares y la Ría de Ribadeo que datan de entre la Edad de Hierro y el periodo romano. Seguidamente, el equipo dirigido por Alfonso Fanjul Pereza nos ofrece un análisis sobre la realidad socio-económica del asentamiento asturianos de Las Vallinas, de fines de la Prehistoria e inicios de la dominación romana, comparándolo además con otros sitios conocidas en la costa del Golfo de Vizcaya. Por otro lado, Mario César Vila y Manuela Pérez Mato en su artículo “El yacimiento de San Esteban (Cacabelos, León) y su relación con Bergidum Flavium: síntesis y resultado de la intervención arqueológica realizada en 2014”, nos muestras el resultado de los trabajos de campo desarrollos con motivo de las obras de modernización de regadíos del Canal Alto del Bierzo. También se incluye en este número el análisis que Carlos Fernández Rodríguez, Eduardo González Gómez de Agüero, Natividad Fuertes Prieto y Víctor Bejega García han realizado sobre los productos del mar localizados en una serie de asentamiento del interior del noroeste de la Península Ibérica durante el periodo de dominación romana. En esta misma línea, el artículo que encabeza Esteban Álvarez Fernández está dedicado al análisis de los restos faunísticos exhumados en el poblado zamorano de El Castillón que data de entre los siglos V y VI.
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Pérez Samper, María de los Ángeles. "Jean-Anthelme BRILLAT SAVARIN, «Fisiología del gusto» (trad. Pablo Batalla Cueto; pról. Eduardo Méndez Riestra; ilust. Alfonso Fernández). Gijón, Ediciones Trea/Fundación Alimerka, 2012, 336 págs." Cuadernos de Estudios del Siglo XVIII, no. 23 (October 20, 2013): 213–16. http://dx.doi.org/10.17811/cesxviii.23.2013.213-216.
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Reyes-Rodríguez, Mae Lynn. "Agradecimiento a personas que contribuyeron en procesos de revisión: Volumen 34, Número 3." Revista Puertorriqueña de Psicologia 34, no. 3 (2024): 468. http://dx.doi.org/10.55611/reps.3403.13.
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Este número especial ha sido posible gracias a la contribución de las personas que asistieron en el proceso de revisión de pares con el propósito de garantizar publicaciones de alta calidad. A continuación, presentamos aquellas personas que colaboraron con la revisión de artículos, publicados o no publicados, que fueron considerados para este número.
 
 Adalberto Campo-Arias, MD, MSc
 Frances L. Centeno Morales, PhD
 Sonia L. Cepeda Hernández, PhD
 Ángel Comas Nazario, PhD
 Giselle Cordero-Arroyo, PhD
 Caroline Correa, PhD
 Irmarie Cruz López, PhD
 Marilis Cuevas Torres, PhD
 Eduardo Cumba Avilés, PhD
 Elixmahir Dávila Marrero, PhD
 Isabel Delgado Quiñones, Ed. D
 Roberto O. Díaz-Juarbe, PhD
 Tania García Ramos, PhD
 Juan A. González Rivera, PsyD
 Aida L. Jiménez Torres, PhD
 Minoshka Liquet Suarez, PhD
 José A. Maldonado Martínez, PhD
 Cristian R. Marrero Díaz, PhD
 Mayra R. Martínez Plana, PhD
 Alfonso Martínez Taboas, PhD
 Jennifer Morales Cruz, PhD
 Inmaculada Muñiz Franceschi, PhD
 Patricia Noboa Ortega, PhD
 Nydia Ortiz Nolasco, PhD
 Lymaries Padilla Cotto, PhD
 Sheila Pérez López, PhD
 Carla Pierri, PhD
 Eriel O. Ramos Méndez, MPH, MA, BBA
 Mario A. Rodríguez Cancel, PhD
 Soélix M. Rodríguez Medina, PhD
 Adam Rosario Rodríguez, PhD
 Solana Salessi, PhD
 Antonio Samaniego Pinho, MSc
 Alejandro Sanín Posada, PhD
 Ana V. Soto-Sánchez, MS
 Natania Tommasino Comesaña, M.S.
 Ivelisse Torres Fernández, PhD
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Administración, Revista Barataria. "Textos y glosas nº 21 - Barataria." Barataria. Revista Castellano-Manchega de Ciencias Sociales, no. 21 (October 31, 2016): 231–42. http://dx.doi.org/10.20932/barataria.v0i21.305.
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Autor de la reseña: César García Álvarez, Universidad de León 
 Obra de: Ignacio GÓMEZ DE LIAÑO 
 El Reino de las Luces. Carlos III entre el viejo y el nuevo mundo 
 Madrid: Alianza Editorial. 2016. 440 pp.
 
 
 Autora de la reseña: Irene Belmonte Martín, Universidad Miguel Hernández. Elche
 Obra de: Marta MÉNDEZ JUEZ
 La economía de los datos públicos en democracia: una visión neoinstitucional
 Navarra: Thomson Reuters Aranzadi. 2016. 324 pp.
 
 Autor de la reseña: Carlos Jiménez Pérez, ACMS 
 Obra de: Álvaro MORCILLO LAIZ y 
 Eduardo WEISZ (Eds.)
 Max Weber en Iberoamérica. Nuevas interpretaciones, estudios empíricos y recepción
 México, D.F.: FCE. 2015. 704 pp.
 
 Autor de la reseña: Alfonso Ortega Giménez, Universidad Miguel Hernández. Elche, Alicante
 Obra de: Fernando GÓMEZ DE LIAÑO GONZÁLEZ 
 Casos y cosas del derecho. Crónicas de un tiempo 
 Oviedo: Editorial Fórum. 2015. 210 pp. 
 
 Autor de la reseña: Eulogio Sánchez Navarro, Universidad Rey Juan Carlos, Madrid 
 Obra de: Giuliano TARDIVO
 Los socialismos de Bettino Craxi y Felipe González. ¿Convergencia o divergencia?
 Madrid: Fragua. 2016. 514 pp.
 
 Autor de la reseña: Santiago Donoso García, ACMS
 Obra de: Francisco ALÍA MIRANDA y 
 Jerónimo ANAYA FLORES (Dirs.)
 I Congreso Ciudad Real y su provincia
 Ciudad Real: Instituto de Estudios Manchegos (CSIC). 2015. 574 pp. (Vol I), 544 pp. (Vol II) y 543 pp. (Volumen III).
 
 Autora de la reseña: Carla Aguilar-Cunill, Universidad Rovira i Virgili 
 Obra de: Ignasi BRUNET, Alejandro PIZZI y David MORAL. 
 Sistemas laborales comparados. Las transformaciones de las relaciones de empleo en la era neoliberal
 Madrid: Anthropos. 2016. 381 pp.
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Mastroianni, Roberto. "Joined Cases C-200/07 and C-201/07, Alfonso Luigi Marra v. Eduardo De Gregorio and Antonio Clemente, Judgment of the Court (Grand Chamber) of 21 October 2008, [2008] ECR I-7929." Common Market Law Review 47, Issue 5 (2010): 1541–55. http://dx.doi.org/10.54648/cola2010065.
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Toledo, Lourdes. "Ressenya a Eduard López-Chavarri, Memorias de un viaje a Italia. Introducció i edició de Rafael Roca, València, Institució Alfons el Magnànim-Centre Valencià d’Estudis i d’Investigació, 2019." SCRIPTA. Revista Internacional de Literatura i Cultura Medieval i Moderna 16 (December 13, 2020): 471. http://dx.doi.org/10.7203/scripta.16.19273.
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Ressenya a Eduard López-Chavarri, Memorias de un viaje a Italia, introducció i edició de Rafael Roca, València, Institució Alfons el Magnànim-Centre Valencià d’Estudis i d’Investigació, 2019, 190 pp. ISBN: 978-84-7822-814-0
 Review to Eduard López-Chavarri, Memorias de un viaje a Italia, introducció i edició de Rafael Roca, València, Institució Alfons el Magnànim-Centre Valencià d’Estudis i d’Investigació, 2019, 190 pp. ISBN: 978-84-7822-814-0
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González, A., J. L. Patier, M. López-Rodríguez, et al. "SAT0322 PREVALENCE AND RISK FACTORS FOR LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN SYSTEMIC SCLEROSIS: RESULTS FROM RESCLE REGISTRY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1106.2–1107. http://dx.doi.org/10.1136/annrheumdis-2020-eular.963.
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Background:Left ventricular diastolic dysfunction (LVDD) is a very common finding in heart involvement in Systemic Sclerosis (SSc).Objectives:To determine the prevalence, risk factors and mortality associated with LVDD in a cohort of patients with SSc.Methods:A retrospective study was conducted with data from the multicentre Spanish Scleroderma Registry (RESCLE). A case-control study was performed to identify factors associated with LVDD.Results:Out of 1517 cases of SSc, 319 (21%) developed LVDD. Basal characteristics are shown in Table 1. In multivariate analysis, LVDD was associated to older age at diagnosis of SSc [54 vs 44 years, OR 1.05 (1,04-1.06)], presence of telangiectasia [67 vs 59%, OR 1.42 (1,88-1.08)], and treatment with calcium channel blockers [50 vs. 45%, OR 1.55 (1.16-1.96)], and inversely correlated to treatment with ACE inhibitors [74 vs. 83%, OR 0.59 (0.44-0.8)]. Mortality was increased in patients with LVDD (24 vs 17%, OR 1.4, p = 0.01). Kaplan–Meier cumulative survival for the SSc cohort, according to the presence or absence of LVDD showed significant differences in 30 years from the first SSc symptom (59 vs. 70%, p = 0.04).Table 1.Number of patients1517319 (21%)1198 (79%)PLimited SSc923 (61%)201 (63%)722 (60%)0.438Diffuse SSc304 (20%)51 (16%)253 (21%)0.041Sine Sclerodema SSc174 (11%)47 (15%)127 (11%)0.048Age at disease onset(years) med±SD46.4±16.554.1±15.944.5±16.1<0.001Arterial hypertensión491 (33%)148 (48%)343 (30%)<0.001Digital ulcers615 (41%)108 (34%)507 (42%)0.006Telangiectasia918 (61%)212 (67%)706 (59%)0.011Interstitial lung disease645 (43%)153 (48%)492 (41%)0.021Pulmonary hypertension139 (9.2%)34 (11%)105 (8.8%)0.325Capillaroscopy Slow pattern673 (51%)130 (46%)543 (53%)0.038Centromere Antibodies679 (49%)154 (55%)525 (48%)0.032Conclusion:In our cohort, LVDD is relative common in SSc patients, and it is associated with older age at diagnosis, treatment with calcium channel blockers and telangiectasia. ACE inhibitors could play a protective role against the development of LVDD. Mortality is higher in SSc patients with LVDD, and is more significative over time.References:[1]Tennøe AHet al. Left Ventricular Diastolic Dysfunction Predicts Mortality in Patients with Systemic Sclerosis. J Am Coll Cardiol. 2018;72:1804-13Disclosure of Interests:Andrés González: None declared, Jose Luis Patier: None declared, Mónica López-Rodríguez: None declared, Alfredo Guillén del Castillo: None declared, Manuel Rubio-Rivas: None declared, Ana Argibay: None declared, Begoña Marí-Alfonso: None declared, Antonio-J Chamorro: None declared, Ana Belén Madroñero-Vuelta: None declared, Eduardo L. Callejas-Moraga: None declared, Cristina González-Echávarri: None declared, Norberto Ortego: None declared, Vicent Fonollosa-Pla Consultant of: Actelion pharmaceuticals, GSK, MSD., Carmen Pilar Simeón-Aznar Consultant of: Actelion pharmaceuticals, GSK, MSD., on behalf of RESCLE Investigators, Autoimmune Diseases Study Group (GEAS): None declared
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Mahmoud Abdelkader, Mohamed, and Óscar Barrero Pérez. "El conocimiento y la relación con Egipto en la cultura española desde 1850 hasta 1900." SIGLO DIECINUEVE (Literatura hispánica), no. 23 (October 31, 2019): 93–146. http://dx.doi.org/10.37677/sigloxix.v0i23.40.
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En este trabajo he abordado la relación cultural de España con Egipto, relación que se remonta a tiempos muy lejanos; de modo que se quedó grabada en la memoria de viajeros, estudiosos españoles y gobernantes egipcios. Partieron desde España en dirección al oriente islámico muchos viajeros, misioneros, conferenciantes del Ateneo de Madrid y escritores que visitaron Egipto, además de fantasiosos que nunca estuvieron allí, como José de Castro y Serrano. Todos ellos redactaron libros, ensayos, cuentos, novelas y memorias que fueron impresas entre 1850 y1914, en las que el tema egipcio encontró un buen asiento y un mejor cultivo. En este clima, emprendió desde España su aventura hacia Egipto don Antonio de orleáns, duque de Montpensier, afincado en Sevilla; era el hijo menor del rey de Francia Luis Felipe de orleáns y estaba casado con la infanta María Luisa, matrimonio del que nacería María de las Mercedes (1860-1878), primera esposa de Alfonso XII (1857-1885). Este viaje de don Antonio de orleáns fue realizado en 1845 según el relato de su secretario Antonio Latour, publicado en 1849. Aquel viaje coincidió en el tiempo con la magnífica expedición prusiana dirigida por el egiptólogo, lingüista y museógrafo Richard Carl Lepsius (1810-1884), que contaba con la aprobación y el apoyo de Federico Guillermo III de Prusia (1770-1840), quien consiguió para las colecciones de sus museos más de quince mil objetos antiguos que fueron llevados a Berlín y regalados oficialmente por Mohamed Alí Bajá de Egipto entre 1805 y 1848. Los orientalistas que pudieron visitar Egipto desde 1840 hasta 1900 pretendían describir la imagen de un Egipto “oriental”, es decir, su objetivo se centraba en destacar los barrios populares, los zocos con carpas, las gentes rezando en las mezquitas y la descripción de los maravillosos monumentos de la civilización faraónica. A mediados del siglo XIX, concretamente en vísperas de la apertura del canal de Suez, España aspiraba a mantener estrechas relaciones con Egipto, basadas principalmente en fines exploratorios, científicos, culturales, y sobre todo, objetivos comerciales y económicos, ya que en aquel entonces Egipto representaba el acceso a las rutas de las especias, extensión y difusión del cristianismo, hegemonía política, etc. España nunca fue ajena a la fascinación por la civilización de Egipto, y desde los primeros años del siglo XIX existieron muchos viajeros y escritores españoles que recorrieron el oriente Próximo y Egipto. Entre ellos, destacamos los nombres de José de Castro y Serrano, José Ramón Mélida, Eduardo Toda y Güell, Antonio Bernal, Arturo Baldasano y Topete, Lázaro Bardón y Gómez.
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Andon, Fernando Torres, Alba Pensado-López, Clement Anfray, et al. "Abstract 715: Nanomedicines loaded with TLR agonists and inhibitors of immunosuppression to reprogram the tumor microenvironment." Cancer Research 84, no. 6_Supplement (2024): 715. http://dx.doi.org/10.1158/1538-7445.am2024-715.
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Abstract The stroma of solid tumors is populated by myeloid cells, which mostly represent macrophages. Tumor-associated macrophages (TAMs), strongly influenced by cancer cell-derived factors, are key drivers of immunosuppression and support tumor growth and spread to distant sites. Increasing evidence demonstrates their ability to hamper cancer patients' response to most treatments currently applied in the clinic, including immunotherapy. Therefore, strategies to counteract negative effects of TAMs are nowadays gaining momentum at preclinical, translational, and clinical levels. Here, we present the development and evaluation of nanoparticles (NPs) loaded with TLR agonists and/or inhibitors of immunosuppressive pathways to reprogram TAMs and the tumor microenvironment (TME) to unleash an effective immune response to fight against the tumor. Firstly, we have evaluated in vitro the ability of poly(I:C) and/or R848, agonists of TLR3 and TLR7/8 respectively, to reprogram TAMs into antitumor effector cells, and also the efficacy of Stattic and/or Galunisertib, inhibitors of STAT3 and TGF-β pathways respectively, to inhibit immunosuppression by cancer cells and/or TAMs. The best combinations of these drugs were encapsulated in nanoemulsions or polymeric nanocapsules for improved TAM-targeting and pharmacokinetics in vivo. These NPs were characterized for their physicochemical properties and also tested in vitro using primary human macrophages. For in vivo evaluation, subcutaneous and orthotopic murine models of lung cancer (CMT167) were used, showing antitumoral efficacy and TME reprogramming as evaluated by FACS, RNA analysis and multiplex immunofluorescence. Protamine-NCs-loaded with poly(I:C)+R848 and coated with an additional layer of hyaluronic acid functionalized with mannose were used to target the CD206 receptors, showing antitumoral efficacy mediated by TAM reprogramming, evaluated as higher CD86 while lower CD206 and Arg1 expression. Nanoemulsions with a PEGylated surfactant, encapsulating Stattic+Galunisertib+R848 showed faster antitumoral activity versus the free drugs. Experiments performed in IFN-γ KO mice and immune deficient mice (NSG and Balb/c nude) revealed that a fully functional immune system is crucial for the response to the treatment. In conclusion, our work demonstrates the antitumoral efficacy and reprogramming of the tumor microenvironment by combinations of TLR agonists and/or inhibitors of immunosuppression, which can be improved by nanotechnological approaches. Further investigations are ongoing to assess their antitumoral efficacy in other tumor models (i.e. breast and pancreatic cancer), with the final aim of clinical translation. Citation Format: Fernando Torres Andon, Alba Pensado-López, Clement Anfray, Aldo Ummarino, Iago Fernández-Mariño, Lucia Sanjurjo, Jose Crecente-Campo, Eduardo Fernández-Megía, Flavia Castro, Maria Jose Oliveira, Alfonso Calvo, Rosario García Campelo, Alberto Mantovani, Maria Jose Alonso, Paola Allavena. Nanomedicines loaded with TLR agonists and inhibitors of immunosuppression to reprogram the tumor microenvironment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 715.
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Melian, Emma, Ana García García de Paredes, Mercedes Rodríguez, et al. "Abstract A012: The Spanish Familial Pancreatic Cancer Registry (PANGENFAM): Genetic testing and follow-up of high risk individuals." Cancer Research 84, no. 2_Supplement (2024): A012. http://dx.doi.org/10.1158/1538-7445.panca2023-a012.
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Abstract Introduction: The Spanish familial pancreatic cancer registry (PANGENFAM) was established in 2009, with the main objective to study the genetic and phenotypic characteristics of familial pancreatic cancer families and offer screening of high-risk individuals for early detection. Methods: Targeted panel and exome sequencing of 52 FPC and 33 sporadic PDAC cases was performed to identify genes and novel variants related to PDAC risk. Healthy high-risk relatives of FPC cases enter into a screening that consists of an annual MRI, echo-endoscopy and routine blood tests, which is followed by a biopsy if a suspicious lesion is identified. Results: The registry and associated biobank is maintained thanks to a stable collaboration between the departments of Medical Oncology, Gastroenterology, Radiology General Surgery and Pathology. The registry currently includes over 150 families and 350 individuals, including PDAC cases and high risk individuals. Targeted sequencing analysis of DNA repair genes involved in familial cancer identified pathogenic variants in 7.5% of FPC cases in the MLH1 and CDKN2A genes, likely pathogenic variants were found in 5.7% of cases in the genes MUTYH, TERT and ATM. Likely pathogenic variants were found in 9.4% of sporadic cases in the genes POLQ, CHEK2 and FANCM and no pathogenic variants were identified. By exome sequencing, missense variants with a damaging effect were found in 11 FPC cases, including stop gain, stop loss or frameshift variants in 5 FPC cases (45.45%), affecting WWOX, C2orf83, CYP3A5 and TANGO2. KRAS somatic mutations in codon 12 and 13 were more frequently detected in sporadic PDAC cases (70%) compared to familial cases (16%) via the liquid biopsy. Interestingly, the median overall survival for sporadic and familial PDAC cases in our cohort was 10.2 vs. 21.7 months (p⇒0.01), respectively, even when adjusted for stage at diagnosis and first line adjuvant therapy. From all the families included in the registry, 185 were offered the high-risk screening program for early detection. Currently 129 individuals are actively participating in the screening program, of which, 72% of these individuals have a non-normal looking pancreas via MRI or EUS. The most commonly detected lesions were cysts and IPMN found in 32% and 12% individuals, respectively. Screening has successfully detected and treated solid lesions in 4 high-risk individuals, including 3 early PDAC and 1 neuroendocrine tumor. An additional 11 individuals with lesions with worrisome features are under close follow-up. Conclusions: Panel sequencing has identified pathogenic variants in known familial cancer genes that are also associated with FPC risk. Exome sequencing in panel negative FPC cases has identified novel risk associated genes. The molecular and clinical profile of FPC and sporadic cases are distinct which should be taken into account in the clinic. Citation Format: Emma Melian, Ana García García de Paredes, Mercedes Rodríguez, Jorge Villalón López, María Muñoz, Javier Blaquez, Ignacio Ruz, Alfonso Sanjuanbenito, Eduardo Lobo, Victoria Lopéz, Carmen Guillen Ponce, José Ramón Foruny Olcina, Sergio López Durán, Alfredo Carrato, Julie Earl. The Spanish Familial Pancreatic Cancer Registry (PANGENFAM): Genetic testing and follow-up of high risk individuals [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Pancreatic Cancer; 2023 Sep 27-30; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84(2 Suppl):Abstract nr A012.
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Cooper, Declan L. M., Simon L. Lewis, Martin J. P. Sullivan, et al. "Consistent patterns of common species across tropical tree communities." Nature CLXVI, no. CLXVI (2024): 1–25. https://doi.org/10.1038/s41586-023-06820-z.
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Cooper, Declan L. M., Lewis, Simon L., Sullivan, Martin J. P., Prado, Paulo I., ter Steege, Hans, Barbier, Nicolas, Slik, Ferry, Sonké, Bonaventure, Ewango, Corneille E. N., Adu-Bredu, Stephen, Affum-Baffoe, Kofi, de Aguiar, Daniel P. P., Ahuite Reategui, Manuel Augusto, Aiba, Shin-Ichiro, Albuquerque, Bianca Weiss, de Almeida Matos, Francisca Dionízia, Alonso, Alfonso, Amani, Christian A., do Amaral, Dário Dantas, do Amaral, Iêda Leão, Andrade, Ana, de Andrade Miranda, Ires Paula, Angoboy, Ilondea B., Araujo-Murakami, Alejandro, Arboleda, Nicolás Castaño, Arroyo, Luzmila, Ashton, Peter, Aymard C, Gerardo A., Baider, Cláudia, Baker, Timothy R., Balinga, Michael Philippe Bessike, Balslev, Henrik, Banin, Lindsay F., Bánki, Olaf S., Baraloto, Chris, Barbosa, Edelcilio Marques, Barbosa, Flávia Rodrigues, Barlow, Jos, Bastin, Jean-Francois, Beeckman, Hans, Begne, Serge, Bengone, Natacha Nssi, Berenguer, Erika, Berry, Nicholas, Bitariho, Robert, Boeckx, Pascal, Bogaert, Jan, Bonyoma, Bernard, Boundja, Patrick, Bourland, Nils, Boyemba Bosela, Faustin, Brambach, Fabian, Brienen, Roel, Burslem, David F. R. P., Camargo, José Luís, Campelo, Wegliane, Cano, Angela, Cárdenas, Sasha, Cárdenas López, Dairon, de Sá Carpanedo, Rainiellen, Carrero Márquez, Yrma Andreina, Carvalho, Fernanda Antunes, Casas, Luisa Fernanda, Castellanos, Hernán, Castilho, Carolina V., Cerón, Carlos, Chapman, Colin A., Chave, Jerome, Chhang, Phourin, Chutipong, Wanlop, Chuyong, George B., Cintra, Bruno Barçante Ladvocat, Clark, Connie J., Coelho de Souza, Fernanda, Comiskey, James A., Coomes, David A., Cornejo Valverde, Fernando, Correa, Diego F., Costa, Flávia R. C., Costa, Janaina Barbosa Pedrosa, Couteron, Pierre, Culmsee, Heike, Cuni-Sanchez, Aida, Dallmeier, Francisco, Damasco, Gabriel, Dauby, Gilles, Dávila, Nállarett, Dávila Doza, Hilda Paulette, De Alban, Jose Don T., de Assis, Rafael L., De Canniere, Charles, De Haulleville, Thales, de Jesus Veiga Carim, Marcelo, Demarchi, Layon O., Dexter, Kyle G., Di Fiore, Anthony, Din, Hazimah Haji Mohammad, Disney, Mathias I., Djiofack, Brice Yannick, Djuikouo, Marie-Noël K., Do, Tran Van, Doucet, Jean-Louis, Draper, Freddie C., Droissart, Vincent, Duivenvoorden, Joost F., Engel, Julien, Estienne, Vittoria, Farfan-Rios, William, Fauset, Sophie, Feeley, Kenneth J., Feitosa, Yuri Oliveira, Feldpausch, Ted R., Ferreira, Cid, Ferreira, Joice, Ferreira, Leandro Valle, Fletcher, Christine D., Flores, Bernardo Monteiro, Fofanah, Alusine, Foli, Ernest G., Fonty, Émile, Fredriksson, Gabriella M., Fuentes, Alfredo, Galbraith, David, Gallardo Gonzales, George Pepe, Garcia-Cabrera, Karina, García-Villacorta, Roosevelt, Gomes, Vitor H. F., Gómez, Ricardo Zárate, Gonzales, Therany, Gribel, Rogerio, Guedes, Marcelino Carneiro, Guevara, Juan Ernesto, Hakeem, Khalid Rehman, Hall, Jefferson S., Hamer, Keith C., Hamilton, Alan C., Harris, David J., Harrison, Rhett D., Hart, Terese B., Hector, Andy, Henkel, Terry W., Herbohn, John, Hockemba, Mireille B. N., Hoffman, Bruce, Holmgren, Milena, Honorio Coronado, Euridice N., Huamantupa-Chuquimaco, Isau, Hubau, Wannes, Imai, Nobuo, Irume, Mariana Victória, Jansen, Patrick A., Jeffery, Kathryn J., Jimenez, Eliana M., Jucker, Tommaso, Junqueira, André Braga, Kalamandeen, Michelle, Kamdem, Narcisse G., Kartawinata, Kuswata, Kasongo Yakusu, Emmanuel, Katembo, John M., Kearsley, Elizabeth, Kenfack, David, Kessler, Michael, Khaing, Thiri Toe, Killeen, Timothy J., Kitayama, Kanehiro, Klitgaard, Bente, Labrière, Nicolas, Laumonier, Yves, Laurance, Susan G. W., Laurance, William F., Laurent, Félix, Le, Tinh Cong, Le, Trai Trong, Leal, Miguel E., Leão de Moraes Novo, Evlyn Márcia, Levesley, Aurora, Libalah, Moses B., Licona, Juan Carlos, Lima Filho, Diógenes de Andrade, Lindsell, Jeremy A., Lopes, Aline, Lopes, Maria Aparecida, Lovett, Jon C., Lowe, Richard, Lozada, José Rafael, Lu, Xinghui, Luambua, Nestor K., Luize, Bruno Garcia, Maas, Paul, Magalhães, José Leonardo Lima, Magnusson, William E., Mahayani, Ni Putu Diana, Makana, Jean-Remy, Malhi, Yadvinder, Maniguaje Rincón, Lorena, Mansor, Asyraf, Manzatto, Angelo Gilberto, Marimon, Beatriz S., Marimon-Junior, Ben Hur, Marshall, Andrew R, Martins, Maria Pires, Mbayu, Faustin M., de Medeiros, Marcelo Brilhante, Mesones, Italo, Metali, Faizah, Mihindou, Vianet, Millet, Jerome, Milliken, William, Mogollón, Hugo F., Molino, Jean-François, Mohd. Said, Mohd. Nizam, Monteagudo Mendoza, Abel, Montero, Juan Carlos, Moore, Sam, Mostacedo, Bonifacio, Mozombite Pinto, Linder Felipe, Mukul, Sharif Ahmed, Munishi, Pantaleo K. T., Nagamasu, Hidetoshi, Nascimento, Henrique Eduardo Mendonça, Nascimento, Marcelo Trindade, Neill, David, Nilus, Reuben, Noronha, Janaína Costa, Nsenga, Laurent, Núñez Vargas, Percy, Ojo, Lucas, Oliveira, Alexandre A., de Oliveira, Edmar Almeida, Ondo, Fidèle Evouna, Palacios Cuenca, Walter, Pansini, Susamar, Pansonato, Marcelo Petratti, Paredes, Marcos Ríos, Paudel, Ekananda, Pauletto, Daniela, Pearson, Richard G., Pena, José Luis Marcelo, Pennington, R. Toby, Peres, Carlos A., Permana, Andrea, Petronelli, Pascal, Peñuela Mora, Maria Cristina, Phillips, Juan Fernando, Phillips, Oliver L., Pickavance, Georgia, Piedade, Maria Teresa Fernandez, Pitman, Nigel C. A., Ploton, Pierre, Popelier, Andreas, Poulsen, John R., Prieto, Adriana, Primack, Richard B., Priyadi, Hari, Qie, Lan, Quaresma, Adriano Costa, de Queiroz, Helder Lima, Ramirez-Angulo, Hirma, Ramos, José Ferreira, Reis, Neidiane Farias Costa, Reitsma, Jan, Revilla, Juan David Cardenas, Riutta, Terhi, Rivas-Torres, Gonzalo, Robiansyah, Iyan, Rocha, Maira, Rodrigues, Domingos de Jesus, Rodriguez-Ronderos, M. Elizabeth, Rovero, Francesco, Rozak, Andes H., Rudas, Agustín, Rutishauser, Ervan, Sabatier, Daniel, Sagang, Le Bienfaiteur, Sampaio, Adeilza Felipe, Samsoedin, Ismayadi, Satdichanh, Manichanh, Schietti, Juliana, Schöngart, Jochen, Scudeller, Veridiana Vizoni, Seuaturien, Naret, Sheil, Douglas, Sierra, Rodrigo, Silman, Miles R., Silva, Thiago Sanna Freire, da Silva Guimarães, José Renan, Simo-Droissart, Murielle, Simon, Marcelo Fragomeni, Sist, Plinio, Sousa, Thaiane R., de Sousa Farias, Emanuelle, de Souza Coelho, Luiz, Spracklen, Dominick V., Stas, Suzanne M., Steinmetz, Robert, Stevenson, Pablo R., Stropp, Juliana, Sukri, Rahayu S., Sunderland, Terry C. H., Suzuki, Eizi, Swaine, Michael D., Tang, Jianwei, Taplin, James, Taylor, David M., Tello, J. Sebastián, Terborgh, John, Texier, Nicolas, Theilade, Ida, Thomas, Duncan W., Thomas, Raquel, Thomas, Sean C., Tirado, Milton, Toirambe, Benjamin, de Toledo, José Julio, Tomlinson, Kyle W., Torres-Lezama, Armando, Tran, Hieu Dang, Tshibamba Mukendi, John, Tumaneng, Roven D., Umaña, Maria Natalia, Umunay, Peter M., Urrego Giraldo, Ligia Estela, Valderrama Sandoval, Elvis H., Valenzuela Gamarra, Luis, Van Andel, Tinde R., van de Bult, Martin, van de Pol, Jaqueline, van der Heijden, Geertje, Vasquez, Rodolfo, Vela, César I. A., Venticinque, Eduardo Martins, Verbeeck, Hans, Veridiano, Rizza Karen A., Vicentini, Alberto, Vieira, Ima Célia Guimarães, Vilanova Torre, Emilio, Villarroel, Daniel, Villa Zegarra, Boris Eduardo, Vleminckx, Jason, von Hildebrand, Patricio, Vos, Vincent Antoine, Vriesendorp, Corine, Webb, Edward L., White, Lee J. T., Wich, Serge, Wittmann, Florian, Zagt, Roderick, Zang, Runguo, Zartman, Charles Eugene, Zemagho, Lise, Zent, Egleé L., Zent, Stanford (2024): Consistent patterns of common species across tropical tree communities. Nature CLXVI (CLXVI): 1-25, DOI: 10.1038/s41586-023-06820-z, URL: http://dx.doi.org/10.1038/s41586-023-06820-z
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Carbonell, C., A. J. Chamorro, M. Marcos, et al. "AB0558 RISK FACTORS FOR THE DEVELOPMENT OF BREAST CANCER IN SYSTEMIC SCLEROSIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1575.1–1576. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2016.
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Background:Prior literature shows a global increase of cancer risk among patients with systemic sclerosis (SSc). Although breast cancer (BC) is one of the most frequent malignancies in SSc patients, the characteristics of this neoplasm among SSc patients is not well established and it is uncertain whether SSc significantly increases the risk of this cancer.Objectives:Describe the characteristics and risk factors for BC among Spanish patients with SSc.Methods:Ambispective and multicenter study of patients with a diagnosis of SSc according to ACR/EULAR criteria and/or LeRoy classification included in the Spanish Scleroderma Registry (RESCLE) from 2006 to 2018. Characteristics of patients with BC were described and incidence was compared with that of the general population.Results:Among 1930 patients with SSc, 206 (10.7%) had cancer. BC was the most frequent tumor location (47 patients of 206 with cancer [22.8%]), followed by lung cancer (29, 14.1%). The risk of BC was increased in patients with SSc compared to the general population (standardized incidence ratio [SIR] 1.31; 95% CI 1.10-1.54;P= 0.003).The comparison of patients with BC and those without cancer showed that patients with BC had older age at diagnosis of SSc (50.9 vs 45.9 years, respectively;P=0.004), were more frequently diagnosed of interstitial lung disease (ILD) (30/47 [63.8%] vs 694/1714 [40.5];P= 0.002) and pulmonary hypertension (12/24 [50.0%] vs 262/917 [28.6%];P= 0.037), had higher frequency of puffy hands as the first manifestation of SSc (4/45 [8.9%] vs 38/1664 [2.3 %];P= 0.023) and had more frequently primary biliary colangitis (PBC) (7 /46 [15.2%] vs 72 /1708 [4.2%];P= 0.004). Regarding autoimmunity profile, patients with SSc and BC had a significantly higher presence of anti-Ro (11/44 [25.0%] vs 214/1528 [14.0%];P= 0.049) and anti-mitochondrial antibodies (7/28 [25.0%] vs 96/837 [11.5%];P= 0.039). Multivariable regression analysis showed an independent association between the puffy hands (OR = 6.40; 95% CI 1.73-23.60;P= 0.005), diagnosis of PBC (OR = 5.70; 95% CI 2.16-15.07;P= 0.001), presence of ILD (OR = 3.29, 95% CI 1.69-6.39;P<0.001) and the presence of the anti-Ro antibody (OR 2.14; 95% CI 1.01-4.56;P= 0.048) with the presence of BC.Conclusion:BC risk was increased in patients with SSc. The development of ILD, PBC, the presence of anti Ro and puffy hands as the first clinical manifestation of SSc were identified as independent factors associated with the development of BC in our cohort.References:Colaci M et al. Breast cancer in systemic sclerosis: results of a cross-linkage of an Italian Rheumatologic Center and a population-based Cancer Registry and review of the literaure. Autoimmun Rev. 2014;13(2):132-7.Zhang JQ et al. The risk of cancer development in systemic sclerosis: a meta-analysis. Cancer Epidemiol. 2013;37(5):523-7.Disclosure of Interests:Cristina Carbonell: None declared, Antonio-J Chamorro: None declared, Miguel Marcos: None declared, Alfredo Guillén del Castillo: None declared, Dolores Colunga Argüelles Consultant of: Actelion pharmaceuticals, GSK, MSD., Manuel Rubio-Rivas: None declared, Ana Argibay: None declared, Begoña Marí-Alfonso: None declared, Adela Marín Ballvé: None declared, Antoni Castro Consultant of: Actelion pharmaceuticals, GSK, MSD., Ana Belén Madroñero-Vuelta: None declared, Eduardo L. Callejas-Moraga: None declared, Vicent Fonollosa-Pla Consultant of: Actelion pharmaceuticals, GSK, MSD., Carmen Pilar Simeón-Aznar Consultant of: Actelion pharmaceuticals, GSK, MSD., on behalf of RESCLE Investigators, Autoimmune Diseases Study Group (GEAS): None declared
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Garneau-Tsodikova, Sylvie. "Book Review of Asymmetric Organic Synthesis with Enzymes Asymmetric Organic Synthesis with Enzymes . Edited by Vicente Gotor (Universidad de Oviedo, Spain), Ignacio Alfonso (Universidad Jaume I, Castellón, Spain), and Eduardo García-Urdiales (EMBL-Biocomputing, Heidelberg, Germany). Wiley-VCH Verlag GmbH & Co. KGaA : Weinheim . 2008 . xiv + 326 pp. $215.00. ISBN 978-3-527-31825-4 ." Journal of the American Chemical Society 130, no. 32 (2008): 10829–30. http://dx.doi.org/10.1021/ja8049047.
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Rummel, Erika. "Political and Religious Propaganda at the Court of Charles V: a Newly‐Identified Tract by Alfonso Valdés." Historical Research 70, no. 171 (1997): 23–33. http://dx.doi.org/10.1111/1468-2281.00029.
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Abstract An anonymous response on behalf of Charles V to statements made by Edward Lee, English ambassador to the imperial court (published in Exhibita quaedam per Eduardum Leum …, Antwerp, 1528), is ascribed to the imperial secretary Alfonso Valdés. There are verbal and contextual parallels between the anonymous response and Valdés's Diálogo de Mercurio y Carón. Both works, moreover, contain references to Erasmus, with whom Lee had engaged in a polemic over the text and interpretation of the new Testament. The exchange, therefore, transcends the political sphere, and pits Valdés, an admirer of Erasmian humanism, against Lee, a defender of the scholastic method.
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Gracia Tello, B., E. Ramos, C. P. Simeón-Aznar, et al. "POS1408 REPRODUCIBILITY OF A NEW AUTOMATIC SYSTEM (CAPILLARY.IO) IN THE ANALYSIS OF NAILFOLD CAPILLAROSCOPY IMAGES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 987.1–987. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4063.
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Background:Nailfold Capillaroscopy is a simple, inexpensive and non-invasive technique that allows microvascular damage to be observed, gaining recent importance in the diagnosis, monitoring and prognosis of many diseases with microangiopathy. However, the variability in the results interpretation has led to the development of new computerized systems that allow the automatic analysis of capillaroscopic images.Objectives:to compare the degree of agreement between the automatic system Capillary.io and a gold standard obtained from the agreement of 9 expert capillaroscopists and to know the degree of the interobserver reliability To demonstrate the validity of the system to detect normal and enlarged capillaries, hemorrhages, megacapillaries, ramifications and tortuosities.Methods:a cross-sectional study was performed in which 300 random and anonymous nailfold capillaroscopic images (1165 capillaries) were analyzed by 9 experienced observers. The degree of interobserver agreement was calculated from the 5 users. Likewise, the system performed an automatic assessment of the images and their agreement with the gold standard was calculated (interobserver agreement greater than 5, 6, 7, 8 and 9 successively). The validity of the program for each variable was also analyzed using sensitivity and specificity, positive and negative predictive values, and likelihood ratios, as well as their degree of agreement using the weighted kappa statistic (95% CI, p <0.05). The programs used for statistical calculations were SPSS 22.0 and EPIDAT 3.0.Results:the degree of interobserver agreement was 76.5% for the agreement of 5 or more observers, progressively decreasing to 15.4% for the 9 observers. Capillary.io obtained higher levels of agreement, reaching 97.7% for the 9 observers. Statistically significant results were obtained in the automated detection of all the morphological alterations analyzed Capillary.io presented a sensitivity (S) of 79.82% and a specificity (E) of 82% in the recognition of normal capillaries. The automatized system was able to recognize enlarged capillaries with a sensitivity of 86.97% and a specificity of 81.38%. Megacapillaries were detected with 89.41% sensitivity and 78.75% specificity. Similarly, the system was able to detect tortuosities (S 66.94%; E 67.71%), ramifications (S 54.34%; E 58.61%) and hemorrhages (S 71.36; E 73.97%).Conclusion:Capillary.io demonstrated a high degree of agreement with the gold standard, stronger with greater consensus among observers. It was able to detect with great sensitivity and specificity hemorrhages and megacapillaries, very relevant alterations in microangiopathies.References:[1]Roldán LMC, Franco CJV, Navas MAM. Capillaroscopy in systemic sclerosis: A narrative literature review. Rev Colomb Reumatol; 2016; 23: 250-8.[2]Ingegnoli F, Gualtierotti R, Lubatti C, Bertolazzi C, Gutierrez M, Boracchi P, et al. Nailfold capillary patterns in healthy subjects: A real issue in capillaroscopy. Microvasc Res. 2013;90:90-5.[3]Cutolo M, Pizzorni C, Secchi ME, Sulli A. Capillaroscopy. Best Pract Res Clin Rheumatol. 2008; 22:1093-108.[4]Tavakol ME, Fatemi A, Karbalaie A, Emrani Z, Erlandsson BE. Nailfold Capillaroscopy in Rheumatic Diseases: Which Parameters Should Be Evaluated? BioMed Res Int. 2015; 2015: 974530.[5]Smith V, Herrick AL, Ingegnoli F, Damjanov N, De Angelis R, Denton CP, et al. Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud’s phenomenon and systemic sclerosis. Autoimmunity Reviews. 2020; 19: 102458.Disclosure of Interests:Borja Gracia Tello Shareholder of: Co-founder and shareholder of Capillary.io., Eduardo Ramos Shareholder of: Co-founder and shareholder of Capillary.io., Carmen Pilar Simeón-Aznar: None declared, Vicent Fonollosa Pla: None declared, Alfredo Guillén-Del-Castillo: None declared, Albert Selva-O’Callaghan: None declared, Luis Sáez-Comet: None declared, Elena Martínez Robles: None declared, Juan José Rios: None declared, Gerard Espinosa: None declared, Jose Antonio Todolí Parra: None declared, Jose Luis Callejas-Rubio: None declared, Norberto Ortego: None declared, Begoña Marí-Alfonso: None declared, Mayka Freire: None declared, Patricia Fanlo: None declared
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Moreno, Paula, Philippe Saiag, Luis de la Cruz Merino, et al. "Abstract CT109: Radiomic features in tumor assessment, preliminary results from a phase 2 study of intratumoral administration of BO-112 with pembrolizumab in patients with anti PD1 refractory melanoma." Cancer Research 82, no. 12_Supplement (2022): CT109. http://dx.doi.org/10.1158/1538-7445.am2022-ct109.
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Abstract Background: There is a lack of predictive biomarkers for immunotherapy in melanoma. Immunohistochemistry and gene sequencing are frequently assessed as part of clinical research. Radiomic signatures may also add valuable information, based on parameters which can be related to immune infiltration, therefore defining an imaging biomarkers panel for this clinical scenario. BO-112 is a double stranded synthetic RNA formulated with polyethyleneimine (PEI) that, by mimicking the effect of a viral infection, mobilizes the immune system. The role of imaging biomarkers is being explored in the present phase II clinical trial. Study design: Single arm study with BO-112 plus pembrolizumab (NCT04570332) in patients with advanced melanoma in progression to anti-PD1 therapy. As part of exploratory objectives, a radiomics analysis was performed to detect changes in lesion texture features. Quantitative features were obtained by using Quibim Precision 2.9 platform (Quibim, Valencia, Spain) after the manual delineation of lesions on the CT study of each subject at each timepoint to obtain information about injected/non-injected lesions. Images were normalized by taking into account Hounsfield Units (HU) bias across scanners in a cross-calibration phantom and the Z-score. The difference (Delta) in the features between baseline and week 8 was calculated. Results: Studies were assessed based on event (progression) and based on whether lesions had been injected. Patients with only cutaneous disease were not included in this analysis. Out of 23 patients who had at least two imaging assessments, 6 developed progressive disease by week 8, and 17 subjects had no event by that time. Due to the small sample size, the radiomic analysis was based on hypothesis testing. With regards to volume, 50% of the non-progressing lesions reduced their value from that of the baseline. Regarding injected versus non-injected changes, up to 50% of injected lesions decreased their volume after 8 weeks of injected treatment whereas in non-injected lesions volume decreased in less than 25% of lesions. From the independent sample t-test of delta radiomics features against the injected/non-injected lesions variable, there were 4 features with a statistically significant difference between groups; all of them related to the Low Grey-Level Zone Emphasis. Specifically, Delta original GLRLM Low Grey-Level Run Emphasis showed the highest significant difference between injected and non-injected lesions (p=0.004), with higher and positive delta values in the injected group (75% injected lesions were above 0). Conclusions: Imaging biomarkers provide a large number of quantitative image features with a wide span of information, from size to heterogeneity of the tissue which may be indicator of tumor progression and immune infiltrate. In the analysis of radiomics features, delta GLRLM low grey-level zone emphasis was sensitive to the tumoral changes happening in injected lesions at week 8. This might add insights into the imaging-based evaluation of immune infiltration in intratumoral immunotherapy and the creation of associated imaging biomarkers panels. Citation Format: Paula Moreno, Philippe Saiag, Luis de la Cruz Merino, Caroline Dutriaux, Eduardo Castanon Álvarez, Caroline Robert, Juan F. Rodríguez-Moreno, Pablo Cerezuela-Fuentes, Ana M. Arance, Henry Montaudié, Miguel F. Sanmamed, María González Cao, María Pilar López Criado, Julie Charles, Alfonso Berrocal, Enrique de Miguel, Elisa Funk-Brentano, Pablo Sau Llanas, Sorilla Prey, Eva Muñoz-Couselo, Delvys Rodríguez Abreu, Juan Martin-Liberal, Ángel Alberich-Bayarri, Javier Sánchez López, Sonia Macia, Marisol Quintero, Marya F. Chaney, Stéphane Dalle, Iván Márquez-Rodas. Radiomic features in tumor assessment, preliminary results from a phase 2 study of intratumoral administration of BO-112 with pembrolizumab in patients with anti PD1 refractory melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT109.
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Márquez-Rodas, Iván, Caroline Dutriaux, Philippe Saiag, et al. "Abstract CT014: Efficacy of intratumoral BO-112 with systemic pembrolizumab in patients with advanced melanoma refractory to anti-PD-1-based therapy: Final results of SPOTLIGHT203 phase 2 study." Cancer Research 82, no. 12_Supplement (2022): CT014. http://dx.doi.org/10.1158/1538-7445.am2022-ct014.
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Abstract Background: BO-112 is a double stranded synthetic RNA formulated with polyethyleneimine that mimics a viral infection. Through dendritic cells activation, increase in CD8 T-cell infiltration and interferons induction, it produces an immunogenic cell death. Phase 1 study (NCT02828098) showed ORR 20% in patients (pts) with anti PD-1 resistant melanoma (mel). Hence phase 2 trial was designed. Study design: Single arm study (NCT04570332) with intratumoral BO-112 plus intravenous pembrolizumab in pts with mel (cutaneous, acral or mucosal) and confirmed progressive disease (PD) while on anti-PD1 based therapy. Pts were treated with BO-112, 1-2 mg on a weekly basis for 7 weeks and thereafter Q3W in 1-8 different lesions. Pembrolizumab 200 mg was administered Q3W. Primary endpoint was overall response rate (ORR) by RECIST 1.1 by independent reviewer. Secondary endpoints included disease control rate (DCR), progression free survival (PFS) and safety. Exploratory objectives included radiomic signatures, itRECIST and evaluation of tumor microenvironment. At least 20% of pts had to achieve response in order to consider primary endpoint met. Results: Recruitment was completed 24th August 2021 with 42 pts; female 43%; median age 66 (rank 27-88). Table summarizes basal characteristics. With 40 evaluable for response pts, 10 achieved response (25%): 3 complete response (CR) and 7 partial response (PR). 17 pts (44%) achieved a stable disease (SD), meaning a DCR of 68% with 18 pts still on treatment. The 4 pts with a baseline LDH&gt;3xULN developed PD no later than week 8. Responses per histology were: 66% mucosal, 28% cutaneous, 0% acral. Responses per BRAF/NRAS status were: BRAF mutant (Mut) 43%, NRAS Mut 31%, and BRAF/NRAS wild type (WT) 17%. 33 pts (79%) had at least one BO-112 related adverse event (AE) being only in 2 cases grade&gt;3 (G4 infusion reaction and G3 myalgia). Most common related AEs were asthenia, pyrexia, diarrhea, vomiting and chills. Study treatment was not discontinued in any pts due to related AE. Conclusions: The primary efficacy endpoint has been met. Additionally, disease control (PR+CR+SD) is meaningful and durable in a population with no current standard treatment options. Very high LDH levels (LDH &gt;3xULN) and acral mel could predict poor outcome. Safety profile was manageable without treatment discontinuation due to AEs. N (ITT pts, 42) (%) AJCC8 M1C/D 19 (45) BRAF Mut 7 (17) WT 35 (83) Previous treatment Ipilimumab-nivolumab 6 (15) Anti PD-1 monotherapy 33 (79) Other combo 3 (7) Prior line indication Adjuvant 11 (26) Advanced 31 (74) LDH &gt;ULN 17 (41) Best ORR (IRCR evaluable pts, N=40) Global Mucosal Cutaneous Acral ORR 10 (25) 2 (66) 8 (28) 0 PR 7 (18) 1 (33) 6 (21) 0 CR 3 (8) 1 (33) 2* (7) 0 SD 17 (43) 1 (33) 13 (45) 3 (37) PD 13 (33) 0 8 (28) 5 (63) *2 pts had pathologic CR and RECIST SD Citation Format: Iván Márquez-Rodas, Caroline Dutriaux, Philippe Saiag, Luis de la Cruz Merino, Eduardo Castanon Álvarez, Caroline Robert, Juan F. Rodríguez-Moreno, Ana M. Arance, Pablo Cerezuela-Fuentes, Henry Montaudié, Miguel F. Sanmamed, María González Cao, Julie Charles, María Pilar López Criado, Alfonso Berrocal, Enrique de Miguel, Elisa Funk-Brentano, Sorilla Prey, María del Carmen Álamo de la Gala, Javier Sánchez López, Helena Escuin-Ordinas, Sonia Macia, Marisol Quintero, Marya F. Chaney, Stéphane Dalle. Efficacy of intratumoral BO-112 with systemic pembrolizumab in patients with advanced melanoma refractory to anti-PD-1-based therapy: Final results of SPOTLIGHT203 phase 2 study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT014.
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Roman, Ruth, Philippe Saiag, Caroline Dutriaux, et al. "Abstract CT107: Correlation of biomarkers and clinical benefit of intratumoral BO112 and pembrolizumab in patients with anti PD1 refractory melanoma." Cancer Research 82, no. 12_Supplement (2022): CT107. http://dx.doi.org/10.1158/1538-7445.am2022-ct107.
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Abstract Background: There is a lack of predictive biomarkers for immunotherapy in melanoma. In terms of IHC, there is no strong rational to support the use of PD-L1 expression. BRAF mutations occur in 40-50% of melanomas and the MAPK pathway may also be activated by NRAS mutations. Patients harboring these mutations face usually a worse prognosis. BO-112 is a double stranded synthetic RNA formulated with polyethyleneimine (PEI) that, by mimicking the effect of a viral infection, mobilizes the immune system. Prior data from a phase I trial (NCT02828098) suggest that, when administered intratumorally, it causes an increase in CD8 infiltration and PD-L1 expression. The role of these and other biomarkers is being explored in the present phase II clinical trial. Study Design: Single arm study with BO-112 plus pembrolizumab (NCT04570332) in patients with advanced melanoma in progression to anti-PD1 therapy. Tumors were genotyped by next generation sequencing, whole exome sequencing and tumor mutation burden. Antitumor and immunological effects of the treatment in the tumor microenvironment were assessed by PDL1 and CD8 immunohistochemistry with a paired biopsy performed after 21 days of treatment. Results: A preliminary analysis has been performed, based on patients evaluable for clinical benefit (defined as response or stable disease&gt;16 weeks). Samples from 35 patients have been analyzed, with 24 patients paired biopsies available. Patients with “cold” tumors (PD-L1 negative and CD8 low) at baseline had a trend to lack of clinical benefit. Only basal PD-L1 in the inflammatory component showed a statistically significant correlation with clinical outcome (4/20 (25%) tumors PDL1 IC negative had benefit versus 10/15 (67%) positive), p=0.0053. Fifteen patients had an increase in PD-L1 and 14 patients had increase in CD8 infiltrate after BO-112 treatment; the lack of increase in PDL1 and CD8 after treatment was also predictive of lack of response (p=0.04). BRAF/NRAS driver mutations correlated with positive outcome. Clinical benefit was observed in 4 of 17 (24%) patients not carrying activating mutations whereas 11 out of 18 (61%) patients with BRAF/NRAS activating mutations had clinical benefit (p=0.02), mainly in cutaneous histology (14% versus 65%, p=0.02). Mucosal melanoma patients (n=3) achieved an ORR 66.7% and DCR 100%. The two mucosal melanoma patients with partial response harbored SETD2 mutations and one of them showed extensive cyclic nucleotide-gated (CNGs), indicative of defects in DNA repair pathways. Regarding acral melanoma patients (n=9), no responses were observed, even in the single case with a NRAS mutation. The only patient achieving clinical benefit, with stable disease&gt;16 weeks; had a unique mutation profile, with TP53 (inactivating) and KIT (activating) mutations. Conclusions: Patients basal mutant BRAF/NRAS could have more probability of benefit from BO-112 and pembrolizumab combination. PD-L1 and/or CD8 increase is an early marker of response. These findings could help to select patients in future clinical trials. Further investigation into predictive biomarkers is warranted. Citation Format: Ruth Roman, Philippe Saiag, Caroline Dutriaux, Luis de la Cruz Merino, Eduardo Castanon, Miguel F. Sanmamed, Caroline Robert, Juan F. Rodríguez-Moreno, Pablo Cerezuela-Fuentes, Ana M. Arance, María González Cao, Henry Montaudié, María Pilar López Criado, Julie Charles, Alfonso Berrocal, María del Carmen Álamo de la Gala, Enrique de Miguel, Elisa Funk-Brentano, Sorilla Prey, Eva Muñoz-Couselo, Delvys Rodríguez Abreu, Juan Martín-Liberal, Helena Escuin-Ordinas, Mark Branum, Sonia Macia, Marisol Quintero, Javier Sánchez López, Marya F. Chaney, Beatriz García-Peláez, Marta Vives-Usano, Miguel Ángel Molina, Stéphane Dalle, Iván Márquez-Rodas. Correlation of biomarkers and clinical benefit of intratumoral BO112 and pembrolizumab in patients with anti PD1 refractory melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT107.
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Gracia Tello, B., E. Ramos, C. P. Simeón-Aznar, et al. "POS0256 AUTOMATED CAPILLARY DETECTION AND IMAGE ANALYSIS SOFTWARE IN CAPILLAROSCOPY: CAPILLARY.IO." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 350.2–351. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4022.
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Background: A nailfold capillaroscopy procedure is a non-invasive, low-cost, and well-established examination that can be used to diagnose several rheumatic autoimmune diseases and support the necessary follow-up of patients. There are two main elements to nailfold capillaroscopy: image acquisition and image interpretation. Both of these can present challenges: we need to ensure that the best possible images are captured, and we need to define the enlarged capillaries, capillary loss and pericapillary hemorrhages objectively. We introduce Capillary.io, an automatic image reading system able to recognize capillaries in images obtained with any microscope, generate automatic measurements of each capillary and take advantage of this information to report capillary morphology. Together it allows a comprehensive analysis that is capable of producing detailed reports for each patient. Objectives: The primary outcome was general sensitivity and specificity, using images assessed by expert capillaroscopists as the gold standard. Methods: 6500 images previously analyzed by capillaroscopists from GREC were compared with Capillary.io. Capillary morphology (enlarged capillaries, tortuosities, ramifications, megacapillaries, hemorrhages) of each of the capillaries contained in each of the images was analyzed manually by at least one expert capillaroscopist. Subsequently, the automatic image interpretation system was used to fully automatically analyze each of the capillaries contained in each image and the results obtained were compared. Results: Overall, a total of 78.347 capillaries were compared, of which 47.734 were normal capillaries, 21.991 enlarged capillaries, 2672 megacapillaries, 8512 tortuosities, 1322 ramifications and 5149 hemorrhages. Capillary.io was able to detect 38.101 normal capillaries, 19.126 enlarged capillaries, 2389 megacapillaries, 5698 tortuosities, 718 ramifications and 3706 hemorraghes. Capillary.io presented a sensitivity (S) of 79.82% and a specificity (E) of 82% in the recognition of normal capillaries. The automatized system was able to recognize enlarged capillaries with a sensitivity of 86.97% and a specificity of 81.38%. Megacapillaries were detected with 89.41% sensitivity and 78.75% specificity. Similarly, the system was able to detect tortuosities (S 66.94%; E 67.71%), ramifications (S 54.34%; E 58.61%) and hemorrhages (S 71.36; E 73.97%). Conclusion: Capillary.io is a simple, easy-learning web-based system to get interpretation of nailfold capillaroscopic images. It may be a very useful tool to standardize the interpretation of capillaroscopic pictures and could provide great research in that field. References: [1]Bernardino V, Rodrigues A, Lladó A, Fernandes M, Panarra A. The Impact of Nailfold Capil- laroscopy in the Approach of Microcirculation. In: Vascular Biology - Selection of Mechanisms and Clinical Applications IntechOpen; 2020. [2]Boulon C, Devos S, Mangin M, Chevoir JDL, Senet P, Lazareth I, et al. Reproducibility of capillaro- scopic classifications of systemic sclerosis: results from the SCLEROCAP study. Rheumatology 2017 jul;56(10):1713–1720. [3]Capillary io, Capillaroscopy made quick, simple and objective; 2020. Available at capillary.io. [4]Chen K, Wang J, Pang J, Cao Y, Xiong Y, Li X, et al. MMDetection: Open MMLab Detection Toolbox and Benchmark. arXiv preprint arXiv:190607155 2019;. [5]Cutolo M, Pizzorni C, Sulli A. Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis - Reply. The Journal of Rheumatology 2000 11;27:2722–2723. [6]Cutolo M, Trombetta AC, Melsens K, Pizzorni C, Sulli A, Ruaro B, et al. Automated assessment of absolute nailfold capillary number on videocapillaroscopic images: Proof of principle and validation in systemic sclerosis. Microcirculation 2018 May;25(4):e12447. Disclosure of Interests: Borja Gracia Tello Shareholder of: Co-founder and shareholder of Capillary.io., Eduardo Ramos Shareholder of: co-founder and shareholder of Capillary.io., Carmen Pilar Simeón-Aznar: None declared, Vicent Fonollosa Pla: None declared, Alfredo Guillén-Del-Castillo: None declared, Albert Selva-O’Callaghan: None declared, Luis Sáez-Comet: None declared, Elena Martínez Robles: None declared, Juan José Rios: None declared, Gerard Espinosa: None declared, Jose Antonio Todolí Parra: None declared, Jose Luis Callejas-Rubio: None declared, Norberto Ortego: None declared, Begoña Marí-Alfonso: None declared, Mayka Freire: None declared, Patricia Fanlo: None declared
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Sánchez-Bayona, Rodrigo, Alfonso Cortes, Juan Miguel Cejalvo, et al. "Abstract PS12-07: Phase II clinical trial of palbociclib and binimetinib in advanced triple-negative breast cancer (TNBC) with hyperactivation of ERK and/or CDK4/6." Cancer Research 84, no. 9_Supplement (2024): PS12–07—PS12–07. http://dx.doi.org/10.1158/1538-7445.sabcs23-ps12-07.
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Abstract Background: We previously demonstrated that a kinase-based taxonomy of TNBC was most parsimonious than next-generation sequencing in defining TNBC subtypes associated with prognostic categories in early disease. The most aggressive TNBC variants were driven by a heterogeneous set of genetic aberrations that converged in the increased activity of 6 kinases: KIT, PNKP, PRKCE, P70S6K, ERK and CDK6 (Nat Commun; 9:3501-18). The combined inhibition of these kinases in pairs led to potent tumor regression in preclinical models, being the most powerful combination that one directed against CDK6 and ERK. This prompted us to design a phase II trial testing the combination of palbociclib (against CDK6) and binimetinib (against the ERK upstream kinase MEK, since no ERK inhibitor was available at that moment outside phase I trials) in advanced TNBC. Hyperactivation of CDK6 and/or ERK was selected as entry criterion. Trial design: This was a single-arm, prospective, multicentric, open-label, phase II investigator-initiated trial. CDK6 and phosphor-ERK levels were measured in tumor samples by immunohistochemistry and normalized with a reference sample collection to a Z-score. Patients with scores for either kinase above the median were candidates for the trial. Key inclusion criteria included metastatic &gt;18year-old TNBC, adequate organ function, measurable disease, and progression to 1-2 prior treatment lines (including immunotherapy, and a PARP inhibitor in case of germline BRCA1/2 mutation). Patients started continuous oral binimetinib at 45 mg/BID and palbociclib 100 mg/day from days 1 to 21, in 28-day cycles. Patients experiencing ≤ grade 1 tolerable side effects as the greatest toxicity were escalated to palbociclib to 125 in cycle 2. RECIST 1.1 and NCI CTC AE V 5.0 were used for assessing disease control (q8 weeks) and toxicity. The primary aims were to assess the efficacy and toxicity of this combination, and the secondary one to detect biomarkers of activity. At the time of trial design, in absence of available Sacituzumab for prescription, the reference PFS to beat in advanced lines for physician’s choice in TNBC was 1.7 month (NEJM; 384:1529-41, 2021). With alpha and beta errors of 0.05 and 0.2, the minimum number of patients to demonstrate a 30% improvement in PFS to 2.5 months was 25. Results: From November 2020 to April 2023, 69 patients were screened and 24 entered the trial (5 positive for phosphor-ERK; 2 for CDK6; 17 for both). Toxicity was generally mild and included grade 1-2 diarrhea (33% of the patients), grade 1-2 asthenia (50%), grade 1-3 neutropenia (75%), grade 2 retinal toxicity (8.3%) and grade 3 rash (4.2%); no grade 4/5 toxicities were observed. Median PFS was 1.83 months (range 0.3 to 11.3+). Phospho-ERK and CDK6 levels were not correlated (Pearson’s R= -0.089; P=0.68); CDK6 levels did not show association with PFS time (R = -0.120; P=0.58). Interestingly, however, phosphor-ERK levels in the baseline tumor sample showed correlation with PFS time (R = 0.428; P=0.037). Conclusion: The combination of palbociclib and binimetinib was generally safe, and PFS time showed correlation with baseline phosphorylation levels of ERK. However, the trial did not meet its primary endpoint. Citation Format: Rodrigo Sánchez-Bayona, Alfonso Cortes, Juan Miguel Cejalvo, Luis Manso, Serafin Morales, Jose A Garcia-Saenz, Jorge Silva, Juan A Guerra, Diego Malón-Giménez, Silvana Mouron, Eduardo Caleiras, Miguel Quintela-Fandino. Phase II clinical trial of palbociclib and binimetinib in advanced triple-negative breast cancer (TNBC) with hyperactivation of ERK and/or CDK4/6 [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PS12-07.
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Manso, Luis, Alfonso Cortes, Juan M. Cejalvo, et al. "Abstract OT2-19-08: Phase IB/II trial of palbociclib and binimetinib in advanced triple-negative breast cancer with hyperactivation of ERK and/or CDK4/6." Cancer Research 82, no. 4_Supplement (2022): OT2–19–08—OT2–19–08. http://dx.doi.org/10.1158/1538-7445.sabcs21-ot2-19-08.
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Abstract Background: Novel effective and safe therapies are required for advanced TNBC after progression to standard-of-care first line treatment with anti-PD-1/L1 + chemotherapy. We have found that the most aggressive TNBC variants are driven by a heterogeneous set of genetic aberrations that converge in the increased activity of 6 kinases: KIT, PNKP, PRKCE, P70S6K, ERK and CDK6 (Nat Commun; 9:3501-18). Although the inhibition of each kinase in monotherapy yielded little efficacy in preclinical models, the combinations targeting pairs of the former kinases led to therapeutic synergy in most cases. The combined inhibition of CDK6 and ERK led to 5-fold increase in overall survival in preclinical TNBC models (PDXs and spontaneous murine cancer models). The greatest activity was observed in models with increased activity of either CDK6 or ERK. Thus, we aimed to test the safety and preliminary efficacy of combined ERK and CDK6 inhibition with binimetinib and palbociclib in women with advanced TNBC with hyperactivation of ERK and/or CDK6. The combination has been preliminary tested in lung cancer, where a phase I dose-escalation trial established the RP2D in binimetinib 45 mg/BID plus Palbociclib 125 mg daily 21/7. Trial design: Single-arm, prospective, multicentric, open-label, phase IB/II trial with intra-patient dose-escalation. Patients candidate for pre-screening will have determined the activity of ERK and CDK6 with an in-house developed assay and acquisition algorithm at the central lab. Those testing positive for either marker will undergo full screening. Patients will start treatment with continuous oral binimetinib at 45 mg/BID and palbociclib 100 mg/day from days 1 to 21, in 28-day cycles. Patients experiencing ≤ grade 1 tolerable side effects as the greatest toxicity will be allowed to escalate to palbociclib to 125 in cycle 2. Fresh biopsies will be harvested at baseline and disease progression, in order to establish patient-derived organoids (PDOs) and perform WES. PBMCs will be harvested at baseline, +24 hours, and at the beginning of cycle 2, to study changes in the immunophenotype. RECIST 1.1 and NCI CTC AE V 5.0 criteria will be used for assessing disease control (q8 weeks) and toxicity. Eligibility criteria: Pre-screening: Women &gt;18 year old diagnosed of advanced, non-curable TNBC; 2) who have received a minimum of 1 treatment line including immunotherapy; 3) no more than 2 treatment lines for advanced disease; 4) Adequate organ function and recovery from previous toxicity to &lt; tolerable G2. Full screening: 5) Demonstration of hyper-activation of CDK6 and/or ERK in the tumor sample; 6) PD to the previous treatment regimen within the last 28 days. Specific aims: Primary: 1) To determine the progression-free survival time of the combination of binimetinib and palbociclib in TNBC patients with hyperactivation of ERK and/or CDK6 in second/third line 2) To assess the safety and tolerability of the former combination Secondary: 1) 6-month PFS rate, response rate, and overall survival of the combination 2) To study biomarkers of sensitivity and primary and acquired resistance to the combination taking advantage of PDOs 3) To determine the immunodynamics of the combination. Statistical methods: The null hypothesis is that the median PFS time for second/third line TNBC with best physician’s choice is 1.7 months (NEJM; 384:1529-41, 2021). With alpha and beta errors of 0.05 and 0.2, the minimum number of patients to demonstrate a 30% improvement in PFS to 2.5 months is 25. Preliminary data suggest that approximately 40% of the patients show hyper-activation of CDK6 and/or ERK; thus, and assuming a methodological failure of 10%, the minimum number of patients to screen is 69. Present accrual/target accrual: 27 screened of 69 planed; 11 accrued of 25 planned Citation Format: Luis Manso, Alfonso Cortes, Juan M Cejalvo, Serafin Morales, Jose A García Saenz, Ramon Colomer, Rodrigo Sanchez-Bayona, Jorge Silva, Juan A Guerra, Diego Malon, Silvana Mouron, Eduardo Caleiras, Miguel Quintela-Fandino. Phase IB/II trial of palbociclib and binimetinib in advanced triple-negative breast cancer with hyperactivation of ERK and/or CDK4/6 [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr OT2-19-08.
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Martínez-Jáñez, Noelia, Purificación Martínez, Cristina Hernando, et al. "Abstract PO1-16-10: BRCA mutated Male Breast Cancer, hallmarks of a distinct disease. Data from the Spanish Male Breast Cancer Registry (GEICAM/2016-04)." Cancer Research 84, no. 9_Supplement (2024): PO1–16–10—PO1–16–10. http://dx.doi.org/10.1158/1538-7445.sabcs23-po1-16-10.
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Abstract Background: Male breast cancer (MBC) accounts for approximately 0.25% of all male cancers and &lt; 1% of all BCs. Its incidence is increasing by 1.1% per year. Most population studies indicate that 10-15% of MBC patients (pts) have a germline BRCA2 mutation (BRCA2 mut). Around 5-10% of BRCA2mut male carriers will develop BC at their lives. Preliminary evidence suggests that BRCA2mut MBC pts tend to have a more aggressive disease. Here we present comparative series of MBC with and without BRCA to gain insight on differences between both groups. Methods: GEICAM/2016-04 (NCT03800355) is a retrospective, observational study which includes data from MBC pts diagnosed between 2000 and 2019 throughout Spain. This analysis includes the 1st unselected 186 pts included in the study, who had BRCA1/2 genes mutational status assessed within clinical practice. BC clinical subtypes are defined: luminal (HR+, HER2-), Triple Negative (TN) (HR-, HER2-), and HER2+ (HR+ or HR-); subtype is unknown in 6% pts. Results: 186 validated pts with BRCA1/2 testing were identified, representing the 24% of pts available in the database at the cut-off date (6-Mar-2023). 36 (19%) pts had germline BRCA1/2 mut (4 pts in BRCA1, 31 pts in BRCA 2 and 1 pt in both BRCA1 and BRCA2), and 150 (81%) pts had BRCA1/2 wild type (wt) or a variant of uncertain significance (VUS)/unknown (UK). Median age at BC diagnosis was 62 (34-87) years, 98% pts were Caucasian, and the median body mass index was 27 (18-46) Kg/m2 (overweight). Prior cancer history was reported in 6% BRCA1/2mut BC pts and 11% BRCA1/2wt or vus/uk, and family history included: 56% BC, 8% ovarian cancer, and 14% prostate cancer (PC). PC as part of prior medical history, cancer family history, and 2nd non-breast primary malignancy, was most frequent in BRCA1/2wt or vus/uk pts, with no statistical differences. At first diagnosis, stages III-IV were higher in BRCA1/2mut pts (28% vs. 17%, p=0.0093). Morphologically, invasive carcinoma of no special type (NST) was the most common pattern (92% in BRCA1/2mut vs. 86% in BRCA1/2wt or vus/uk), and lobular invasive carcinoma was not reported up-to-date. Histological grade 2 was the most frequent (54%), but grade 3 was present in 17/36 BRCA1/2mut pts. 88% pts received adjuvant treatment, 7% (neo-)adjuvant, 2% neoadjuvant and 3% did not receive any systemic therapy. Breast conserving surgery was performed in 4% (5/140) BRCA1/2wt or vus/uk EBC pts, and mastectomy was performed in 55% (n=6/11) de novo metastatic pts. In the advanced setting (n=38), visceral lesions were more frequent in BRCA1/2mut pts. Additionally, 92% BRCA1/2mut pts had ≤ 3 organs involved while one third of BRCA1/2wt or vus/uk pts had ≥ 4 metastatic locations. With a median follow-up of 64 months (mo.), median iDFS and DDFS were higher, but not statistically significant, in BRCA1/2wt or vus/uk pts vs. BRCA1/2mut pts. In advanced setting, median PFS to 1L-3L do not show statistically significant differences between both groups. Regarding OS, no differences were also observed, but the median values were not reached. Further detailed information according to BRCA1/2 mutational status and BC subtypes is included in the table below. Conclusions: In this subset analysis of GEICAM/2016-04, BRCA1/2mut pts had some features of worse prognosis, with a more prevalent de novo metastatic disease. No statistically significant differences were observed in outcomes in both early-stage and advanced setting vs. BRCA1/2wt or vus/uk pts. &lt;graphic&gt; Citation Format: Noelia Martínez-Jáñez, Purificación Martínez, Cristina Hernando, Sabela Recalde, Alfonso Sánchez, David Morales, Marta Santisteban, Isaura Fernández, Sonia Del Barco, Esther Zamora, Vega Iranzo, Tamara Martos, Eduardo Martínez-de Dueñas, Silvia Antolin Novoa, Severina Domínguez, Paula Domínguez, Mª José Echarri, Ana Santaballa Bertrán, Xavier Mira, Andrea Blasco, Susana Bezares, Ander Urriticoechea. BRCA mutated Male Breast Cancer, hallmarks of a distinct disease. Data from the Spanish Male Breast Cancer Registry (GEICAM/2016-04) [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO1-16-10.
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Ribeiro, Vicente, and Paul Arteaga. "Entre la siembra petrolera y la crítica del extractivismo." Estudios de Lingüística del Español 49 (December 20, 2024): 33–42. https://doi.org/10.36950/elies.2024.49.3.
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A lo largo del siglo XX, Venezuela se consolidó como una nación exportadora de petróleo, un rasgo crucial no solo en términos económicos, sino también políticos y culturales. Los discursos asociados a su condición de “nación petrolera” vincularon los proyectos futuros a la apropiación y distribución de la renta petrolera, sintetizados en la expresión “sembrar el petróleo”. Durante las últimas décadas, diversos proyectos políticos han dado contenido a esta consigna, apuntando a transformar la riqueza petrolera en una fuente permanente, autosostenible y que beneficie a todos los venezolanos. En este artículo, discutimos la fuerza de esta metáfora, dialogando especialmente con la obra de Fernando Coronil. Reflexionamos sobre cómo se naturalizan los efectos del petróleo, a pesar de que su distribución está relacionada con la capacidad de compra en el mercado externo derivada de su exportación. Analizamos, en contraste, la perspectiva de Juan Pablo Pérez Alfonzo, quien en las décadas de 1960 y 1970 criticó la dependencia petrolera utilizando la metáfora del "excremento del diablo". Para él, la abundancia de divisas asociadas al petróleo conducía al despilfarro. Pérez Alfonzo proponía limitar la explotación petrolera para evitar los efectos negativos de la abundancia de divisas y promover un desarrollo económico sostenible. El texto asocia esta perspectiva crítica con los debates contemporáneos sobre el extractivismo en América Latina. Destacamos cómo autores como Eduardo Gudynas critican el modelo extractivista, señalando que la dependencia de la exportación de recursos naturales debilita los vínculos productivos internos y causa impactos sociales y ambientales adversos. Finalmente, reflexionamos sobre las promesas del nacionalismo petrolero y la crítica actual al extractivismo como claves para comprender la historia reciente de Venezuela y otros países de la región.
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Sandu-Dediu, Valentina. "The Beginnings of Romanian Composition: Between Nationalism and the Obsession with Synchronizing with the West." Nineteenth-Century Music Review 14, no. 3 (2017): 315–37. http://dx.doi.org/10.1017/s1479409817000179.
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Romanian composition in the nineteenth century went through rapid changes, moving from a Greek-oriental sound world to a Western European one. It is interesting to examine, in this context, the musicians’ quest for a ‘national’ sound and identity. Analysis of piano miniatures or vaudeville, the favourite genre of the Romanian audience in the first half of the century, shows eclectic combinations of urban folk music with sources of inspiration borrowed from popular foreign melodies. The second half of the century seems to be marked in modern scholarship by premieres: some composers are included in Romanian history just for the merit of writing the first Romanian symphony, the first string quartet, the first opera, and so forth. Their work led towards the constitution of a ‘national language’ adapted to genres borrowed from contemporary Western European music.In addition to demonstrating these ideas in the work of a number of Romanian composers (Josef Herfner, Ioan Andrei Wachmann, Anton Pann, Alexandru Flechtenmacher, Ludwig Anton Wiest, Carol Miculi, George Stephănescu, Constantin Dimitrescu, Gavriil Musicescu, Eduard Caudella, George Dima, Ciprian Porumbescu, Iacob Mureşianu, Dumitru Georgescu Kiriac, Alfonso Castaldi, Eduard Wachmann), the present article also encompasses two case studies. The first is Franz Liszt’s tour through the Romanian Countries, which offers a clearer image of the popular ideas circulating within the musical scene of the time. Liszt’s initiative to emphasize the national spirit through folk quotations reworked in rhapsodies should have inspired Romanian musicians; we will see whether this actually happened. The second case study concerns the musical life of Bucharest around 1900, when the directions of Romanian modern music were being traced, and cautious and selective steps were made toward harmonizing with Europe began.
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Olivier, Guilhem. "Le Codex de Xicotepec. Étude et interprétation/El Códice de Xicotepec. Estudio e interpretación." REVISTA TRACE, no. 30 (March 14, 2019): 83–85. https://doi.org/10.22134/trace.30.1996.709.
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Moins spectaculaire que les grandes découvertes archéologiques, la mise à jour d’un nouveau manuscrit pictographique indigene du XVIe siècle représente pourtant un événement exceptionnel. À l’instar de l’apparition des peintures murales de Bonampak et de Cacaxtla ou de l’exhumation de la Pierre de Coyolxauhqui et de la tombe de Pacal à Palenque, la révélation par Guy Stresser-Péan et son épouse Claude Stresser-Péan de l’existence du Codex de Xicotepec conservé dans le village de Cuaxicala contribue à cette entreprise fascinante et jamais achevée qu’est la reconstitution du passé du Mexique. À ce titre, l’auteur s’inscrit dans une longue tradition française de publication de manuscrits pictographiques parmi lesquels nous pouvons citer la section Cortesiano du Codex de Madrid par l’abbé Brasseus de Bourbourg, le Codex Peresianus par León de Rosny, les Mappe Quinatzin et Mappe Tlotzin par Joseph Marius Alexis Aubin ou encore l’ensemble des manuscrits édités par le duc de Loubat (Tonalamatl Aubin, Codex Borgia, Codex Fejérváry-Meyer, Codex Vaticanus 3773, Codex Magliabechiano et Codex Telleriano-Remensis). À travers le commentaire qui accompagne la publication du Codex de Xicotepec, Guy Stresser-Péan apparaÎt a la fois comme l’héritier de brillants spécialistes tels Eduard Seler, Francisco del Paso y Troncoso, Alfonso Caso ou J. Eric S. Thompson mais aussi comme un chercheur novateur qui ouvre de nouvelles perspectives dans l’étude des manuscrits pictographiques indigènes.
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Simonoff, Alejandro. "Treinta años de consensos y disensos en el Mercosur." CUPEA Cuadernos de Política Exterior Argentina, no. 135 (June 29, 2022): 143–50. http://dx.doi.org/10.35305/cc.vi135.137.
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Hasta la segunda década del nuevo milenio existió un elemento de continuidad en la vinculación con el mundo desde 1983, y fue la estructura triangular que puso al tope de nuestra agenda a Washington y Brasilia -utilizándolos como contrapesos-, en un marco predominantemente cooperativo, dejando a un lado las oscilaciones del pasado y donde el Mercosur cumplió un rol relevante. Las diferencias estuvieron en las acciones con que las dos tendencias predominantes utilizaron el Triángulo. Podemos delinear: la primera, la autonomista, que consistió en buscar márgenes de maniobra, como ocurrió durante los gobiernos de Raúl Alfonsín, Eduardo Duhalde, Néstor Kirchner y Cristina Fernández, que apuntaron a establecerlos con países de similares recursos y valores; y la segunda, la globalista que privilegió la relación con la potencia hegemónica, como en las administraciones de Carlos Menem y de Fernando de la Rúa. Si bien en principio las administraciones de Alberto Fernández y Mauricio Macri pueden ser ubicadas en esas categorías respectivamente, el nuevo marco de una estructura romboidal, por la incorporación de China a la ecuación junto a Brasilia y Washington, nos lleva a la necesidad de repensar tanto las estrategias como los instrumentos para su concreción.
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Pasado y Memoria, Revista. "Reseñas." Pasado y Memoria. Revista de Historia Contemporánea, no. 21 (July 1, 2020): 339. http://dx.doi.org/10.14198/pasado2020.21.15.
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Reseñas: TRAVERSO, Enzo, Melancolía de izquierda. Después de las utopías, Barcelona, Galaxia Gutenberg, 2019, 416 pp. / Xavier María Ramos Diez-Astrain; PRO, Juan, La construcción del Estado en España. Una Historia del siglo XIX, Madrid, Alianza Editorial, 2019, 761 pp. / Antonio Moliner Prada; ZURITA ALDEGUER, Rafael, Europa en la época de Napoleón, Madrid, Síntesis, 2019, 251 pp. / Víctor Sánchez Martín; BARBASTRO GIL, Luis, Los Premonstratenses: su presencia en España (1143-1835), Alicante, Instituto Alicantino de Cultura Juan Gil Albert, 2019, 317 pp. / Antonio Moliner Prada; VÁZQUEZ GARCÍA, Francisco, Pater Infamis. Genealogía del cura pederasta en España (1880-1912), Madrid, Cátedra, 2020, 294 pp. / José Benito Seoane Cegarra; RAMOS PALOMO, María Dolores; ORTEGA MUÑOZ, Víctor J. (coords.), Biografías, identidades y representaciones femeninas. Una cita con la historia, Zaragoza, Libros Pórtico, 2019, 319 pp. / Irene Mendoza Martín; LÓPEZ ZAPICO, Misael Arturo; FELDMAN, Irina Alexandra (eds.), Resistiendo al imperio. Nuevas aproximaciones al antiamericanismo desde el siglo XX hasta la actualidad, Madrid, Sílex, 2019, 277 pp. / Sergio Molina García; PRESTON, Paul, Un pueblo traicionado. Corrupción, incompetencia política y división social, Madrid, Prenguin Random House Grupo Editorial, 2019, 776 pp. / Nicolás Buckley; ROWE, Laura, Morale and Discipline in the Royal Navy during the First World War, Cambridge, Cambridge University Press, 2018, 280 pp. / Agustín Daniel Desiderato; VADILLO MUÑOZ, Julián, Historia de la CNT. Utopía, pragmatismo y revolución, Madrid, Los Libros de la Catarata, 2019. 278 pp. / Sergio Nieves Chaves; HERRERÍN LÓPEZ, Ángel, Camino a la anarquía. La CNT en tiempos de la Segunda República, Madrid, Siglo XXI, 2019, 463 pp. / Eduardo González Calleja; IBÁÑEZ TARÍN, Margarita, Los profesores de Segunda Enseñanza en la Guerra Civil, PUV, Valencia, 2019, 302 pp. / Isabel Domenech Jiménez; CIMINO, Marcello, Storia del separatismo siciliano. 1943-1947, Roma, Edizioni dell’Asino, 2019, 200 pp. / Juan M. de Lara Vázquez; MOLINERO, Carme; YSÀS, Pere (eds.), Transiciones. Estudios sobre Europa del Sur y América Latina, Madrid, Catarata, 2019, 269 pp. / Glicerio Sánchez Recio; Rodríguez-Flores, Vega, Fer país. Comunismo valenciano y problema nacional (1970-1982), Valencia, Institució Alfons el Magnànim, 2018, 323 pp. / Xavier Domènech Sampere.
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Pansera de Araujo, Maria Cristina, Maria Simone Vione Schwengber, Celso José Martinazzo, and Solange Castro Schorn. "Editorial Ensino de Paisagem e Educação Ambiental e Formação em Ciências e Matemática." Revista Contexto & Educação 31, no. 99 (2017): 1. http://dx.doi.org/10.21527/2179-1309.2016.99.1-2.
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<p>O número 99 caracteriza-se por apresentar um conjunto de artigos temáticos. O primeiro tema, expresso em cinco artigos de autores espanhóis, aborda o ensino do conceito de paisagem e educação ambiental, que é problematizado no texto de apresentação escrito pelo Dr Alfonso García De La Vega, da Universidade Autonoma de Madrid, organizador dessa demanda especifica. No texto, “<em>El Paisaje y la Educación Ambiental”, </em><strong>Alfonso García De La Vega, Universidad Autónoma de Madrid (Espanha) </strong>presenta media docena de trabajos relacionados con el tema: el paisaje y la educación ambiental, que se aborda desde una perspectiva multidisciplinar, aunque con especial atención al enfoque geográfico. La geografía siempre ha ofrecido una visión global de la relación entre el ámbito natural y las intervenciones humanas, cuyas transformaciones han generado paisajes culturales singulares.</p><p>Outro tema agrega os artigos sobre a formação docente em Ciências e Matemática, submetidos espontaneamente por autores brasileiros e portugués.</p><p>No artigo “<em>As marcas sociais deixadas pelas escolas em nossos professores de ciências: a questão da violência simbólica</em>”, Graciella Watanabe e Ivã Gurgel propõem que elas são deixadas na memória e evocadas nas situações cotidianas onde se apresentam na forma do <em>habitus</em> em diversas reações que são convocadas pelo campo profissional. Esse trabalho pretende recuperar os aspectos sociais que marcaram um conjunto de 136 professores de ciências da escola básica (fundamental e média) em sua trajetória histórica e as influencias na sua atuação profissional.</p><p class="Default">Maria Eduarda Roque Ferreira, Carla Cepa, Rosa Tracana e Carlos Francisco Reis, no texto <em>“</em><em>RECICLAR RECORDAÇÕES COM AS CIÊNCIAS - PERCURSOS DE APRENDIZAGEM EM CONTEXTO DE JARDIM-DE-INFÂNCIA”,</em> partiram do pressuposto que a educação se baseia em premissas sociais, culturais, individuais e coletivas. Neste contexto, foi desenvolvida, com um grupo de crianças da educação pré-escolar, uma experiência pedagógico-didática intitulada <em>Reciclar Recordações - A Magia das Ciências</em>, que foi trabalhada<em> </em>de modo<em> </em>interdisciplinar e operacionalizada através da realização de atividades práticas, tendo por enfoque a triangulação ciência-criança-meio sociocultural.</p><p class="Default">Andrea Inês Goldschmidt, Nathália Vieira Silva, Jenyffer Soares Estival Murça e Brucce Sanderson Prado de Freitas, no artigo “<em>O QUE É CIÊNCIA? CONCEPÇÕES DE LICENCIANDOS EM CIÊNCIAS BIOLÓGICAS E QUÍMICA”</em>, procuraram identificar e analisar as concepções sobre Natureza da Ciência entre acadêmicos dos cursos de graduação (licenciatura) em Ciências Biológicas e Química, da Universidade Federal de Goiás e a partir desta, analisar os contextos epistemológicos que a cercam.</p><p>Por fim, Mazonilde Dalvina Costa Souza, Márcia Jussara Hepp Rehfeldt, Ieda Maria Giongo, no artigo “<em>A APRENDIZAGEM DA GEOMETRIA POR MEIO DE OBRAS CUBISTAS NO 5º ANO DA EDUCAÇÃO DE JOVENS E ADULTOS – EJA”, </em>apresentam<em> </em>o resultado da pesquisa desenvolvida no Mestrado Profissional em Ensino de Ciências Exatas do Centro Universitário UNIVATES, que teve como objetivo identificar de que forma o estudo do movimento cubista pode contribuir na aprendizagem significativa da Geometria no 5º ano da Educação de Jovens e Adultos – EJA na Escola Municipal Maria Gertrudes Mota de Lima. Tal pesquisa se fundamentou na teoria de aprendizagem de David Ausubel e nos documentos que regem a Educação de Jovens e Adultos. Foram consultadas obras, como Ausubel (2003), Moreira (2011), Fainguelernt e Nunes (2006).</p><p>Convidamos a leitura dos textos, visto que propõem novas reflexões sobre temas tão caros a educação e ao ensino.</p><p align="right">Maria Cristina Pansera-de-Araújo</p><p align="right">Maria Simone Vione Schwengber</p><p align="right">Celso José Martinazzo</p><p align="right">Solange Castro Schorn</p><p> </p>
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Baliutytė, Elena. "“Don’t go picking apples with the devil”: the myth of Faust in the works of Eduardas Mieželaitis." Literatūra 61, no. 1 (2019): 78–89. http://dx.doi.org/10.15388/litera.2019.1.4.
Full textAbstract:
This article analyzes the reflection on the myth of Faust in the work of Eduardas Mieželaitis (1919–1997). The author’s initial hypothesis that the interpretation of this myth can be used as another argument for revealing the poet’s dramatic feelings and self-reflection of inauthentic Soviet existence is tested. Together with other signs of existential self-abuse (such as the metaphors of “the ringed bird” and “the masked word”), this could help answer the question of whether the description of the 1920s generation (Alfonsas Nyka-Niliūnas, Bronius Krivickas, etc.) as “tragic” would fit Mieželaitis. Intertextuality is the best way to describe the nature of the analysis and socio-criticism would describe the interpretation of the results.E. Mieželaitis was (and still is) one of the most intertextual Lithuanian authors. The use of the “alien word” in his texts was a conceptual position of the poet’s creative consciousness. For him the world’s culture has become a central topic, and his texts have been occupied by the masters of arts and sciences of antiquity, Renaissance, or New Age, as well as modern European authors, Oriental classics, Bible quotations, paraphrases, allusions and other forms of culture. For the poet, Goethe’s Faust is one of such foundational texts, even if the Soviet era did not favor the “myths of the great contemplation” (Vytautas Kubilius). The forever relevant myth of Faust raises a fundamental question of person’s life choice – what one is prepared to sacrifice for one’s purpose, and what the results of that “sacrifice” are. But in the Soviet times Mieželaitis did not focus on this myth as a “symbol of the duality of human’s nature” – his human is rather one-dimensional and monolithic, full of positive energy directed towards technological progress and an absolute belief in the cognitive powers of man. This is the exact aspect that Faust embodies in Mieželaitis’ works, as if it was his “new man”, the product of the Enlightenment era. Mieželaitis did not care about the moment of negotiations between Faust and Mephistopheles – for him there could easily be no Mephistopheles. However, in late works (Postskriptumai, 1986; Gnomos, 1987; Laida, 1992), where the poet reflects on his life and creative path, there are many signs of disillusionment with the myth of human omnipotence as the results of his labor have turned against him – he wanted to create a heaven, but got a hell in the form of Hiroshima. It is at this point that Mephistopheles dominates the duet with Faust, but in general they have both become a “common place” and their function is limited by the text’s aesthetic figurativeness.My conclusion is that eventually the rich allusions to Faust in Mieželaitis’ works did not translate into reflections on the essence or meaning of being – he was not concerned with the problematics of human’s choices, duality, or contradictions. Thus, my initial expectation that the interpretation of the Faust myth may be another argument for revealing the poet’s dramatic feelings and self-reflection of inauthentic existence in the Soviet times was essentially not confirmed. And that could have been another argument for adding him to the social group of the 1920s.On the other hand, looking from the distant present, it is my opinion that Mieželaitis is still a part of the tragic generation, as the whole generation – whether they retreated to the West, or remained in Soviet Lithuania, collaborated or resisted – became hostages of the Second World War and the Soviet occupation.