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Journal articles on the topic 'Effectiveness simvastatin'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Hjalte, Krister, Björn Lindgren, and Ulf Persson. "Cost-Effectiveness of Simvastatin Versus Cholestyramine." PharmacoEconomics 1, no. 3 (1992): 213–16. http://dx.doi.org/10.2165/00019053-199201030-00009.

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2

Wong, George Kwok Chu, Min Liang, Haibin Tan, et al. "High-Dose Simvastatin for Aneurysmal Subarachnoid Hemorrhage." Neurosurgery 72, no. 5 (2013): 840–44. http://dx.doi.org/10.1227/neu.0b013e31828ab413.

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Abstract BACKGROUND: Experimental evidence has indicated the benefit of simvastatin in the treatment of subarachnoid hemorrhage. However, no clinical data are available to answer whether a high-dose regimen is more effective than a normal-dose regimen, even though the biochemical actions and related neuroprotective mechanisms are thought to be dose related. OBJECTIVE: To determine whether 80 mg simvastatin daily (high dose) over 3 weeks initiated within 96 hours of the ictus will reduce the incidence of delayed ischemic deficits after subarachnoid hemorrhage compared with 40 mg simvastatin dai

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Jisha, U.*1 Prasanth S. S.2 Sibina M. K.3 Sanooja P.K.4 K. T. Akshara5 Riya Rajan6 Mohammed Farooq7 Ajay A.8. "A Review On Mastering Bioanalytical Sample Preparation Techniques: Achieving Accurate Analysis." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3806–21. https://doi.org/10.5281/zenodo.13371808.

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The Self-Double Emulsifying Drug Delivery System (SDEDDS) was a type of system where particles of one substance were dispersed within another. Simvastatin, a drug that lowered cholesterol, had a short half-life and only 5% bioavailability due to first-pass metabolism, making it a good candidate for SDEDDS. This study focused on improving Simvastatin's solubility and dissolution rate and various formulations of Simvastatin were prepared using SDEDDS, and all demonstrated quick emulsification times, high cloud points, and acceptable viscosity levels. The efficiency with which the drug was entrap

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Ariani, Ariani, Putrya Hawa, and Syaefudin Ali Akhmad. "Comparison between Effectiveness of Pomegranate Juice (Punica granatum) and Simvastatin for Lowering Blood LDL Level in Hypercholesterolemic Male Rats (Rattus novergicus)." Bangladesh Journal of Medical Science 15, no. 2 (2016): 216–19. http://dx.doi.org/10.3329/bjms.v15i2.28791.

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Background: Coronary heart disease (CHD) is one of the leading causes of death in developed and developing countries. In Indonesia 26% of death is caused by CHD. Hypercholesterolemia is one of the risk factors for CHD. Simvastatin is a hypolipidemic drug which has a significant number of side effects such as myopathy. While, Pomegranate juice (Punica granatum) contains anthocyanin, cathechins, tanin, vitamin C and vitamine E which have beneficial effects to decrease blood LDL level. Objective: The aim of this study was to compare the effectiveness of pomegranate juice (Punica granatum) and sim

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&NA;. "Simvastatin improves cost effectiveness of costly interventions." Inpharma Weekly &NA;, no. 1183 (1999): 5. http://dx.doi.org/10.2165/00128413-199911830-00010.

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6

Di Veroli, C., and R. Pastorelli. "Effectiveness and tolerability of simvastatin versus pravastatin." Current Therapeutic Research 52, no. 1 (1992): 1–6. http://dx.doi.org/10.1016/s0011-393x(05)80429-1.

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Rayasilp, Kritsakorn, Piyanuch Wonganan, Pajaree Chariyavilaskul, Nuntaporn Prompila, Varumporn Sukkummee, and Supeecha Wittayalertpanya. "Effect of Pomelo Juice on the Pharmacokinetics of Simvastatin, CYP3A2 Activity and Mdr1a, Mdr1b and Slc21a5 Expressions in Rats." Pharmaceutical Sciences 25, no. 4 (2019): 303–10. http://dx.doi.org/10.15171/ps.2019.45.

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Background: Food-drug interaction can decrease drug effectiveness or increase risk of drug toxicity. Simvastatin is widely used for treatment of hypercholesterolemia and hypertriglyceridemia. Therefore, this study aimed to investigate the effects of pomelo juice on the pharmacokinetics of simvastatin, CYP3a2 activity and Mdr1a, Mdr1b and Slc21a5 expressions in rats. Methods: Rats were divided into 4 groups including (i) control, (ii) pomelo that received pomelo juice orally twice daily for 7 days, (iii) simvastatin that received simvastatin on day 8, and (iv) simvastatin + pomelo juice. Plasma

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Aboutaleb, Nahid, Mahdieh Mehrab Mohseni, and Maryam Naseroleslami. "Cardioprotective effects of simvastatin‑loaded nano‑niosomes on cardiomyocytes in cardiac ischemia." Medical Journal of Tabriz University of Medical Sciences 45, no. 3 (2023): 111–23. http://dx.doi.org/10.34172/mj.2023.026.

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Background. Cardiac ischemia is the major cause of morbidity and mortality which can be increased by Statins. This study aimed to increase the effectiveness of simvastatin in the form of niosomes. Methods. In this study, 25 male Wistar rats were divided into 5 groups: control, ischemia (induced by closed LAD), ischemia receiving nano-niosomes, ischemia receiving simvastatin, and ischemia receiving simvastatin-loaded nano-niosomes. One month after the drug injection, RNA was extracted from the heart tissue of the studied groups, cDNA was synthesized, and a real-time PCR test was performed using

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9

Neetika Gupta, Sherry Verma, Siddharth Sharma, et al. "Effectiveness Of 1.2% Simvastatin Gel as an Adjunct to Non-Surgical Therapy in The Treatment of Chronic Periodontitis: A Split Mouth Randomized Controlled Trial." International Healthcare Research Journal 4, no. 12 (2021): OR1—OR6. http://dx.doi.org/10.26440/ihrj/0412.03396.

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BACKGROUND: Periodontitis is an inflammatory disease that results in bone resorption creating bony defects, which may cause tooth loss. AIM: The present study aimed to evaluate the effectiveness of 1.2% Simvastatin gel as an adjunct to non-surgical therapy to treat chronic periodontitis (CP). MATERIALS AND METHOD: 25 patients with 50 sites were categorized into two treatment groups: Scaling and Root Planing plus 1.2% Simvastatin, and Scaling and Root Planing with placebo. Clinical parameters; site-specific plaque index, modified sulcus bleeding index (mSBI), pocket probing depth (PD), and rela

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Lu, Jinya, Hongli Cai, Yefei Li, and Jiayi Chen. "Effectiveness of simvastatin/aspirin combination in the treatment of coronary heart disease in the elderly, and its effect on cardiac function and levels of inflammatory factors." Tropical Journal of Pharmaceutical Research 21, no. 5 (2022): 1095–100. http://dx.doi.org/10.4314/tjpr.v21i5.26.

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Purpose: To investigate the efficacy of simvastatin plus aspirin in the treatment of coronary heart disease in the elderly, and its effect on cardiac function and inflammatory factor levels.Methods: Eighty-seven identified elderly patients with coronary heart disease who were admitted to Nantong First People's Hospital, Nantong, China between January 2020 and June 2021 were recruited and assigned at a ratio of 1:1 to receive either conventional treatment (group A) or simvastatin plus aspirin (group B). The clinical endpoint was treatment efficacy.Results: No significant differences were found

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&NA;. "Gemfibrozil vs simvastatin - consider cost-effectiveness and efficacy." Inpharma Weekly &NA;, no. 844 (1992): 9. http://dx.doi.org/10.2165/00128413-199208440-00006.

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Menditto, Enrica, and Anna Citarella. "Valutazione economica dello studio IDEAL." Farmeconomia. Health economics and therapeutic pathways 8, no. 2S (2007): 23–26. http://dx.doi.org/10.7175/fe.v8i2s.1026.

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Introduction: the IDEAL (“High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction”) study was carried out to compare intensive lowering of low-density lipoprotein (LDL)-cholesterol using the highest recommended dose of atorvastatin 80 mg with simvastatin 40 mg. Aim: our aim was to investigate the economic consequence of high dose of atorvastatin vs usual-dose of simvastatin in reducing major coronary events in patients with a history of acute myocardial infarction (AMI). Methods: the analysis is based on clinical outcome data from the IDEAL study.

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Khan, Junad, Maryam Altuhafy, and Gunjan Agrawal. "Effectiveness of simvastatin with antibiotics compared to other material on clinical and radiographic outcomes following non-surgical endodontic treatment." International journal of health sciences 9, no. 1 (2025): 65–88. https://doi.org/10.53730/ijhs.v9n1.15498.

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Postoperative endodontics complications can influence the patient's quality of life. One method of lesion sterilization and tissue repair (LSTR) therapy combines simvastatin with metronidazole, ciprofloxacin, and minocycline, which are used for primary teeth. This review assesses the clinical and radiographic effects of combining simvastatin with antibiotics compared with other materials on pediatric patients. The study protocol was registered on the International Prospective Register of Systematic Reviews with registration number CRD42024552895. The following electronic databases were utilize

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Wang, CC, AK Biddle, and JF Farley. "PCV71 COST-EFFECTIVENESS OF EZETIMIBE/SIMVASTATIN VERSUS SIMVASTATIN: WILL THE INCREASED RISK OF CANCER MAKE EZETIMIBE/SIMVASTATIN AN INAPPROPRIATE TREATMENT CHOICE?" Value in Health 12, no. 3 (2009): A154. http://dx.doi.org/10.1016/s1098-3015(10)73832-8.

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15

Gryskiewicz, Kristen A., Craig I. Coleman, Effie L. Gillespie, and C. Michael White. "Cost-Effectiveness Analysis of Combination Statin/Ezetimibe Therapy for the Treatment of Elevated Low-Density Lipoprotein Cholesterol." Hospital Pharmacy 40, no. 8 (2005): 687–92. http://dx.doi.org/10.1177/001857870504000808.

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Purpose Although statins have been shown to reduce LDL-C and coronary heart disease risk, it is not uncommon for patients to fail to reach NCEP ATP III goals. Some statins cannot lower LDL-C sufficiently; others cannot be titrated optimally due to drug interactions and adverse effects. Concomitant ezetimibe administration can augment LDL-C reduction over statin monotherapy; however, multidrug therapy may result in additional expense. Methods We conducted a cost-effectiveness analysis (CEA) from the hospital perspective including all FDA approved statins alone (fluvastatin, lovastatin, pravasta

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Bodnar, Liubov, Nataliia Polovko, Nataliia Bevz, Volodymyr Hrudko, and Olesia Perepelytsia. "Biopharmaceutical justification of the creation of self-emulsifying drug delivery systems with simvastatin." ScienceRise: Pharmaceutical Science, no. 2(42) (April 30, 2023): 4–10. http://dx.doi.org/10.15587/2519-4852.2023.277351.

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The aim of the research – to conduct biopharmaceutical tests of capsules with a self-emulsifying delivery system of simvastatin to confirm the effectiveness and feasibility of introducing into the composition of self-emulsifying drug delivery systems active pharmaceutical ingredients that are difficult to dissolve in the gastric juice environment. Material and methods. Substances, excipients, reagents and materials used during research were simvastatin (India, p. DK40-2005021, 99.09 %), castor oil (Ukraine), polyethylene glycol 40 hydrogenated castor oil (India), Tween 80 (Ukraine), glyc

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Liubov, Bodnar, Polovko Nataliia, Bevz Nataliia, Hrudko Volodymyr, and Perepelytsia Olesia. "Biopharmaceutical justification of the creation of self-emulsifying drug delivery systems with simvastatin." ScienceRise: Pharmaceutical Science, no. 2(42) (April 30, 2023): 4–10. https://doi.org/10.15587/2519-4852.2023.277351.

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<strong>The aim of the research </strong>– to conduct biopharmaceutical tests of capsules with a self-emulsifying delivery system of simvastatin to confirm the effectiveness and feasibility of introducing into the composition of self-emulsifying drug delivery systems active pharmaceutical ingredients that are difficult to dissolve in the gastric juice environment. <strong>Material and methods. </strong>Substances, excipients, reagents and materials used during research were simvastatin (India, p. DK40-2005021, 99.09 %), castor oil (Ukraine), polyethylene glycol 40 hydrogenated

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18

Kolovou, Genovefa, Georgia Ragia, Vana Kolovou, et al. "Impact of CYP3A5 Gene Polymorphism on Efficacy of Simvastatin." Open Cardiovascular Medicine Journal 8, no. 1 (2014): 12–17. http://dx.doi.org/10.2174/1874192401408010012.

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Background: One of the promises of human genetics is individualized therapy. Therefore, we evaluated the impact of CYP3A5 gene polymorphism on the effectiveness of simvastatin (a HMG-CoA reductase inhibitor). Methods: Patients (n = 191) with hypercholesterolemia were treated with simvastatin for at least 6 months and were genotyped for the CYP3A5 polymorphism. Results: The frequency of CYP3A5 polymorphism was 0.5% for WT (wild-type), 15.6% for HT (heterozygous, expressors) and 83.9% for HM (homozygous, non-expressors). Differences in lipid profile before and after dose-response of simvastatin

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Gangadhar, Bhargavi, Savitha Janakiraman, and and Nataraju Angaswamy. "Evaluation of the effectiveness of soil fungi in the bioconversion of lovastatin to simvastatin and optimization of the cultivation medium." Biomedicine 44, no. 4 (2024): 428–34. https://doi.org/10.51248/v44i4.139.

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Introduction and Aim: Simvastatin, a cholesterol-lowering drug, was manufactured industrially utilizing a multi-step semi-synthetic approach using lovastatin, naturally derived from Aspergillus terreus. Biocatalytic techniques are also used as a viable alternative. We provide an inexpensive mycological method for the bioconversion of lovastatin to simvastatin with easy downstream exertion. Methodology: Overall, 35 fungi and 2 Actinomycetes sp. were tested for bioconversion by culturing them in potato dextrose broth with lovastatin (1mgml) for 7 days at 28C with shaking (110 rpm). Analysis empl

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Costa, Francesco Vittorio, and Orietta Zaniolo. "Simvastatin: between clinics and health economics." Farmeconomia. Health economics and therapeutic pathways 8, no. 1 (2007): 27–45. http://dx.doi.org/10.7175/fe.v8i1.253.

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Statins reduce the incidence of cardiovascular events, one of the most important public health problems and among the main leading causes of death. Their use has been increasing in the last decade and today they represent the first drug class in terms of public expenditure. In view of the introduction of generic simvastatin in the Italian market, this paper outlines a pharmacological and economic profile of this compound. Despite two decades of life, simvastatin remains competitive with other HMG-CoA inhibitors, inducing a dose-dependent, up to 43% cLDL reduction. In clinical trials evaluating

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Kadikoylu, Gurhan, Vahit Yukselen, Irfan Yavasoglu, and Zahit Bolaman. "Hemostatic Effects of Atorvastatin versus Simvastatin." Annals of Pharmacotherapy 37, no. 4 (2003): 478–84. http://dx.doi.org/10.1345/aph.1c189.

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OBJECTIVE: To compare the effects of simvastatin and atorvastatin on hemostatic parameters. METHODS: Sixty-one patients with primary hypercholesterolemia without coronary heart disease were treated with atorvastatin 10–20 mg/d or simvastatin 10–20 mg/d. At baseline, 4, 12, and 24 weeks, lipid levels such as low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), very-low-density lipoprotein cholesterol (VLDL-C), triglycerides (TGs), and hemostatic parameters such as platelet counts, partial thromboplastin time (PTT) prothrombin time (P

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Pescina, Silvia, Fabio Sonvico, Adryana Clementino, Cristina Padula, Patrizia Santi, and Sara Nicoli. "Preliminary Investigation on Simvastatin-Loaded Polymeric Micelles in View of the Treatment of the Back of the Eye." Pharmaceutics 13, no. 6 (2021): 855. http://dx.doi.org/10.3390/pharmaceutics13060855.

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There is increasing consensus in considering statins beneficial for age-related macular degeneration and in general, for immune and inflammatory mediated diseases affecting the posterior segment of the eye. However, all available data relate to oral administration, and safety and effectiveness of statins directly administered to the eye are not yet known, despite their ophthalmic administration could be beneficial. The aim was the development and the characterization of polymeric micelles based on TPGS or TPGS/poloxamer 407 to increase simvastatin solubility and stability and to enhance the de

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Betha, Hymasree, M. Rajmohan, Radhika Thakkar, et al. "Evaluation of Crestal Bone Levels using Simvastatin as an Adjuvant Around Immediate Implants – A Clinico Radiographic Study." Journal of Pharmacy and Bioallied Sciences 16, Suppl 1 (2024): S279—S282. http://dx.doi.org/10.4103/jpbs.jpbs_492_23.

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ABSTRACT Objective: Simvastatin was used as an adjuvant medication in this clinico-radiographic investigation to assess the impact on crestal bone levels around immediate implantation. Materials and Methods: A randomized controlled trial with 50 patients who needed an implant placed right away was done. Simvastatin was used as an adjuvant in groups ((Group A), whereas group (Group B)) served as the control group for the participants. At baseline and during follow-up visits, clinical measures such as probing depth (PD) and bleeding on probing (BOP) were measured. At baseline and 12 weeks, radio

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De Portu, Simona, Sabato Montella, Enrica Menditto, Simona Cammarota, Anna Citarella, and Lorenzo G. Mantovani. "IDEAL trial: economic analysis." Farmeconomia. Health economics and therapeutic pathways 9, no. 1 (2008): 49–52. http://dx.doi.org/10.7175/fe.v9i1.215.

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Introduction: the IDEAL (“High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction”) study was carried out to compare intensive lowering of low-density lipoprotein (LDL)-cholesterol using the highest recommended dose of atorvastatin 80 mg with simvastatin 20 mg. Aim: our aim was to investigate the economic consequence of high dose of atorvastatin vs usual-dose of simvastatin in reducing major coronary events in patients with a history of acute myocardial infarction (AMI). Methods: the analysis is based on clinical outcome data from the IDEAL study.

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Hirsch, Mark, John C. O'donnell, and Peter Jones. "Rosuvastatin is Cost-Effective in Treating Patients to Low-Density Lipoprotein-Cholesterol Goals Compared with Atorvastatin, Pravastatin and Simvastatin: Analysis of the Stellar Trial." European Journal of Cardiovascular Prevention & Rehabilitation 12, no. 1 (2005): 18–28. http://dx.doi.org/10.1177/204748730501200104.

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Background Rosuvastatin calcium (CRESTOR®) has demonstrated superior efficacy in reducing low-density lipoprotein cholesterol (LDL-C). However, healthcare providers and authorities require information on its cost-effectiveness in the treatment of dyslipidaemia. Design A retrospective pharmacoeconomic analysis was performed using data from the Statin Therapies for Elevated Lipid Levels compared Across doses to Rosuvastatin (STELLAR) trial. The cost-effectiveness of rosuvastatin 10-40 mg was compared with atorvastatin 10-80 mg, pravastatin 10-40 mg and both branded and generic simvastatin 10-80

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Rahmawati Raising, Oktaviarika Dewi Hermawatiningsih, and Wiwi Rumaolat. "Efektivitas Penggunaan Obat Dislipidemia terhadap Kadar LDL pada Pasien Cardiovaskular Penyebab Stroke." INSOLOGI: Jurnal Sains dan Teknologi 3, no. 4 (2024): 442–48. http://dx.doi.org/10.55123/insologi.v3i4.4013.

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Dyslipidemia is one of the main risk factors for cardiovascular disease, and cholesterol management therapy has significant benefits in the primary and secondary prevention of coronary heart disease and stroke. Therefore, lipid-lowering therapy, especially using HMG-CoA reductase inhibitors (statins), aims to assess the effectiveness of using statin-class dyslipidemia medications, such as simvastatin and atorvastatin, in reducing LDL levels in cardiovascular patients at X Hospital. This research method uses an observational analytic study with a retrospective research design. This study employ

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Sukanty, Ni Made Wiasty, Farida Ariani, and Lina Yunita. "The Effectiveness of Fragrant Pandan Leaves Ethanol Extract in Reducing Cholesterol Levels In High-Fat Diet-Induced Rats." Biology, Medicine, & Natural Product Chemistry 13, no. 2 (2024): 505–9. http://dx.doi.org/10.14421/biomedich.2024.132.505-509.

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Coronary heart disease was the primary cause of death in Asia in 2019. Indonesia is the country with the highest increase in cholesterol levels in Southeast Asia. One of the causes of coronary heart disease is consuming foods high in cholesterol. The commonly given therapy is simvastatin. However, long-term use of simvastatin can cause side effects, so it is necessary to use other alternatives. Pandanus ammaryllifolius also known as fragrant pandan is a plant that is often found in Indonesia and is used in the culinary industry. This study aims to test the effectiveness of fragrant pandan leav

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Davletshina, Alina Yu, and Konstantin M. Lomonosov. "Pathogenetic justification of the use of simvastatin in the complex therapy of vitiligo." Russian Journal of Skin and Venereal Diseases 24, no. 3 (2021): 227–42. http://dx.doi.org/10.17816/dv62227.

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BACKGROUND: Vitiligo is a chronic acquired disease with a genetic predisposition to pigmentation disorder caused by the destruction of skin melanocytes, leading to hypopigmentation. The effectiveness of currently available methods of treatment of vitiligo, on average, is about 40%. Therefore, it is necessary to search for new effective and safe methods of vitiligo therapy, characterized by minimal risk of side effects, and financial costs of the patient. Simvastatin inhibits cholesterol biosynthesis by inhibiting HMC-CoA reductase. In addition to lowering cholesterol, statins have pleiotropic

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Lindgren, P., J. Graff, A. G. Olsson, T. J. Pedersen, and B. Jonsson. "Cost-effectiveness of high-dose atorvastatin compared with regular dose simvastatin." European Heart Journal 28, no. 12 (2006): 1448–53. http://dx.doi.org/10.1093/eurheartj/ehm020.

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Miller, Michael, Christina Dolinar, William Cromwell, and James D. Otvos. "Effectiveness of high doses of simvastatin as monotherapy in mixed hyperlipidemia." American Journal of Cardiology 87, no. 2 (2001): 232–34. http://dx.doi.org/10.1016/s0002-9149(00)01327-8.

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Severens, JL, MH Prins, and HC Monteban. "PCV72 COST-EFFECTIVENESS OF ATORVASTATIN COMPARED TO SIMVASTATIN IN THE NETHERLANDS." Value in Health 6, no. 6 (2003): 671. http://dx.doi.org/10.1016/s1098-3015(10)61716-0.

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Chong, Camilla, Steven Kelly, and Matthew Bradley. "Effectiveness of low doses of simvastatin versus atorvastatin: Resolving conflicting evidence." Clinical Therapeutics 24, no. 2 (2002): 325–26. http://dx.doi.org/10.1016/s0149-2918(02)85028-7.

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Ara, R., A. Pandor, J. Stevens, et al. "Prescribing high-dose lipid-lowering therapy early to avoid subsequent cardiovascular events: is this a cost-effective strategy?" European Journal of Preventive Cardiology 19, no. 3 (2011): 474–83. http://dx.doi.org/10.1177/1741826711406616.

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Background: While evidence shows high-dose statins reduce cardiovascular events compared with moderate doses in individuals with acute coronary syndrome (ACS), many primary care trusts (PCT) advocate the use of generic simvastatin 40 mg/day for these patients. Methods and results: Data from 28 RCTs were synthesized using a mixed treatment comparison model. A Markov model was used to evaluate the cost-effectiveness of treatments taking into account adherence and the likely reduction in cost for atorvastatin when the patent expires. There is a clear dose–response: rosuvastatin 40 mg/day produces

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Agustin, Emiliya Dwi, Lucia Vita Inandha Dewi, and Inaratul Rizkhy Hanifah. "Analisis Efektivitas Biaya Pengobatan Golongan Statin dalam Manajemen Penyakit Jantung Koroner Di RSUD Kota Madiun 2021/2022." Jurnal Mandala Pharmacon Indonesia 9, no. 2 (2023): 282–90. http://dx.doi.org/10.35311/jmpi.v9i2.363.

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Penyakit Jantung Koroner (PJK) menjadi salah satu prevalen dengan angka yang cukup tinggi di Indonesia. Pengobatan utama yang digunakan di RSUD Kota Madiun adalah golongan HMG-CoA Reduktase Inhibitor atau Statin, yaitu atorvastatin dan simvastatin. Penggunaan obat jangka panjang, biaya perawatan rumah sakit, frekuensi kunjungan ke dokter dan biaya pengobatan PJK menjadi beban yang signifikan. Tujuan dari studi ini adalah mengetahui cost effective antidislipidemia golongan statin pada penyakit jantung koroner. Pendekatan metode yang digunakan adalah deskriptif non-interventional, yaitu dengan m

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McAuley, Daniel F., John G. Laffey, Cecilia M. O’Kane, et al. "Simvastatin to reduce pulmonary dysfunction in patients with acute respiratory distress syndrome: the HARP-2 RCT." Efficacy and Mechanism Evaluation 5, no. 1 (2018): 1–80. http://dx.doi.org/10.3310/eme05010.

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Background Acute lung injury is a common devastating clinical syndrome characterised by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure, and is a major cause of morbidity and mortality. Objective This study tested the hypothesis that treatment with simvastatin would improve clinical outcomes in patients with acute respiratory distress syndrome (ARDS). Design This was a multicentre, allocation-concealed, randomised, double-blind, parallel-group trial. Setting/participants Patients in intensive care units were eligible if they were intubated and m

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Bashir, Dr Sumbul, Dr D. Gopalakrishnan, and Dr Santosh Martande. "Locally Delivered 1.2% Simvastatin Gel and 1% Metformin Gel in Chronic Periodontitis Patients." Saudi Journal of Oral and Dental Research 7, no. 8 (2022): 182–91. http://dx.doi.org/10.36348/sjodr.2022.v07i08.001.

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Background: This study was carried out to investigate the effectiveness of 1.2% Simvastatin gel and 1% Metformin gel in chronic periodontitis pockets. The rationale behind using Statins is that this class of drugs has a potential anti-inflammatory effect on oral epithelial cells, blocking the intermediate metabolites of the mevalonate pathway. Statins also modulate bone formation by increasing the expression of bone morphogenetic protein-2 providing a new direction in the field of periodontal therapy. Statin administration decreases GCF levels of pro-inflammatory mediators which are responsibl

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Kayikçioğlu, Meral, Filiz Özerkan, and İnan Soydan. "Effectiveness and safety of alternate-day simvastatin and fenofibrate on mixed hyperlipidemia." American Journal of Cardiology 83, no. 7 (1999): 1135–37. http://dx.doi.org/10.1016/s0002-9149(99)00030-2.

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Kinosian, Bruce, Henry Glick, and J. Sanford Schwartz. "Scandinavian simvastatin survival study (4S): Cost-effectiveness (CE) of cholesterol lowering treatment." Journal of the American College of Cardiology 27, no. 2 (1996): 165. http://dx.doi.org/10.1016/s0735-1097(96)80887-4.

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Artini, Budi, Elyana Asnar, and Ika Yuni Widyawati. "RED ROSELLA TEA AND AVOCADO AS SIMVASTATIN THERAPY SUPPORT REDUCE TOTAL CHOLESTEROL." Jurnal Ners 12, no. 1 (2017): 113. http://dx.doi.org/10.20473/jn.v12i1.2316.

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Introduction: Hypercholesterolemia is a condition characterized by high levels of total cholesterol in the blood. Many studies have proven that steeping tea rosella and flesh of an avocado can reduce total cholesterol levels. This study was conducted to determine the effectiveness of therapy companion rosella tea and avocado in lowering total cholesterol levels in hypercholesterolemia clients. Method: This type of research is a quasi-experimental study with pre-post test control group design. The population study was a client with hypercholesterolemia in the working area of menganti health cen

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El Sayed, Nesrine S., Esraa A. Kandil, and Mamdooh H. Ghoneum. "Probiotics Fermentation Technology, a Novel Kefir Product, Ameliorates Cognitive Impairment in Streptozotocin-Induced Sporadic Alzheimer’s Disease in Mice." Oxidative Medicine and Cellular Longevity 2021 (July 8, 2021): 1–18. http://dx.doi.org/10.1155/2021/5525306.

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Alzheimer’s disease (AD) is a neurodegenerative disease characterized by cognitive impairment. Gut microbiota dysfunction (dysbiosis) is implicated in the pathology of AD and is associated with several detrimental consequences, including neurotransmitter depletion, oxidative stress, inflammation, apoptosis, and insulin resistance, which all contribute to the onset of AD. The objective of this study was to assess the effectiveness of Probiotics Fermentation Technology (PFT), a kefir product, in alleviating AD symptoms via regulation of the gut microbiota using a streptozotocin- (STZ-) induced A

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Sequetto, Priscila L., Reggiani V. Gonçalves, Aloísio S. Pinto, et al. "Low Doses of Simvastatin Potentiate the Effect of Sodium Alendronate in Inhibiting Bone Resorption and Restore Microstructural and Mechanical Bone Properties in Glucocorticoid-Induced Osteoporosis." Microscopy and Microanalysis 23, no. 5 (2017): 989–1001. http://dx.doi.org/10.1017/s1431927617012363.

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AbstractBy using an experimental model of dexamethasone-induced osteoporosis we investigated the effects of different therapeutic schemes combining sodium alendronate (SA) and simvastatin on bone mineral and protein composition, microstructural and mechanical remodeling. Wistar rats were randomized into eight groups: G1: non-osteoporotic; G2: osteoporotic; G3, G4, and G5: osteoporotic+SA (0.2, 0.4, and 0.8 mg/kg, respectively); G6, G7, and G8: osteoporotic+SA (0.2, 0.4, and 0.8 mg/kg, respectively)+simvastatin (0.4, 0.6, and 1 mg/kg, respectively). Osteoporosis was induced by dexamethasone (7

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Feyziev, Elvin E., Boris S. Sukovatykh, Alexander S. Belous, Maria A. Zatolokina, Elena V. Trubnikova, and Ekaterina S. Mishina. "Combined Correction of Experimental Critical Ischemia of the Lower Extremities in a Rat Model." International Journal of Biomedicine 11, no. 3 (2021): 372–75. http://dx.doi.org/10.21103/article11(3)_oa16.

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The purpose of our research was to study the effectiveness of correcting experimental critical ischemia (CI) of the lower extremities with a combination of udenafil, simvastatin, and autologous bone marrow mononuclear cells (ABMMC). Methods and Results: The experiments were carried out on 24-month-old Wistar rats, weighing 220–250g. The animals were randomized by sex and weight. Groups were formed according to the manipulations carried out during the operations. The animals were divided into 7 groups, each with 20 animals: Group 1 included intact animals; Group 2 - falsely operated animals; Gr

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Ruslin, Ruslin, Henny Kasmawati, Suriani Suriani, Sundar Ihsan, and Desi Sartina. "Activity Assay of Etanol Ectract of Lansau As Antihyperlipidemic." Indonesian Journal of Pharmaceutical Science and Technology 6, no. 3 (2019): 118. http://dx.doi.org/10.24198/ijpst.v6i3.21611.

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Hyperlipidemia is a condition due to increased levels of total cholesterol such as triglycerides, Low Density Lipoprotein (LDL) and decreased levels of High Density Lipoprotein (HDL). Hyperlipidemia can trigger wall thickening and narrowing of arteries, this condition can cause abnormality of fat metabolism in the blood and creates chronic disease. Lansau herb of the Muna tribe of Southeast Sulawesi consists of 44 ingredients of medicinal plants empirically used to treat various diseases such as koleseterol. The aim of this study was to determine the effect of ethanolic extract to the hispatol

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Wang, Xiao-lei, Tuo Zhang, Liu-hua Hu, et al. "Comparison of Effects of Different Statins on Contrast-Induced Acute Kidney Injury in Rats: Histopathological and Biochemical Findings." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/6282486.

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Statins are a promising new strategy to prevent contrast-induced acute kidney injury (CI-AKI). In this study we compared the ameliorative effect of different statins in a rat model of CI-AKI. Sprague-Dawley rats were divided into five groups: control group; CI-AKI group; CI-AKI + rosuvastatin group (10 mg/kg/day); CI-AKI + simvastatin group (80 mg/kg/day); and CI-AKI + atorvastatin group (20 mg/kg/day). CI-AKI was induced by dehydration for 72 hours, followed by furosemide intramuscular injection 20 minutes before low-osmolar contrast media (CM) intravenous injection. Statins were administered

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Sarel, Zufarisky, and Kristina Simanjuntak. "Pengaruh Pemberian Ekstrak Teh Hijau (Camellia sinensis L.) terhadap Penurunan Kadar Kolesterol Total Tikus Wistar (Rattus norvegicus) Diabetes Induksi Aloksan." Jurnal Sehat Mandiri 15, no. 1 (2020): 98–111. http://dx.doi.org/10.33761/jsm.v15i1.195.

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Green Tea works as an anti-dyslipidemia due to chronic hyperglycemia of diabetes through its flavonoid content. The purpose of this study was to determine the effectiveness of green tea extracts on reducing the total cholesterol levels of alloxan-induced diabetes Wistar rats. The study design uses true experimental. Samples were 30 Wistar strain male white rats, aged 8-12 weeks, weighing ±200 grams. Green tea extract doses of 200, 400, and 800 mg/kg body weight, and negative controls were given alloxan, and positive controls were given simvastatin. The treatment group except the normal group w

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Jonsson, B., M. Johannesson, J. Kjekshus, A. G. Olsson, T. R. Pedersen, and H. Wedel. "Cost-effectiveness of cholesterol lowering: Results from the Scandinavian Simvastatin Survival Study (4S)." European Heart Journal 17, no. 7 (1996): 1001–7. http://dx.doi.org/10.1093/oxfordjournals.eurheartj.a014994.

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Miller, PS, A. Davies, and M. Marotti. "PCV71 COST-EFFECTIVENESS OF ROSUVASTATIN COMPARED WITH GENERIC SIMVASTATIN IN THE UK NHS." Value in Health 8, no. 6 (2005): A110. http://dx.doi.org/10.1016/s1098-3015(10)67482-7.

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Grundy, Scott M., Gloria L. Vega, Zhong Yuan, Wendy P. Battisti, William E. Brady, and Joanne Palmisano. "Effectiveness and tolerability of simvastatin plus fenofibrate for combined hyperlipidemia (the SAFARI trial)." American Journal of Cardiology 95, no. 4 (2005): 462–68. http://dx.doi.org/10.1016/j.amjcard.2004.10.012.

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Briseño, Germán Gómez, and Dolores Mino-León. "Cost-effectiveness of rosuvastatin versus ezetimibe/simvastatin in managing dyslipidemic patients in Mexico." Current Medical Research and Opinion 26, no. 5 (2010): 1075–81. http://dx.doi.org/10.1185/03007991003694498.

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He, Wei, Benshun Chen, Bin Yin, Jianren Ye, and Yucai He. "Efficient Biosynthesis of Monacolin J through Enzymatic Hydrolysis Using a Recombinant Lovastatin Hydrolase." Processes 12, no. 9 (2024): 2006. http://dx.doi.org/10.3390/pr12092006.

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Simvastatin is a widely used statin medication that is commonly prescribed to lower cholesterol levels and reduce the risk of cardiovascular events. It is marketed under the brand name Zocor and is known for its effectiveness in treating high cholesterol and managing cardiovascular disease. Monacolin J is an important precursor used to synthesize simvastatin and is mainly produced by chemical methods in industry. Here, monacolin J was synthesized through an enzymatic method under optimized reaction conditions. One recombinant Escherichia coli BL21 (DE3) strain containing lovastatin hydrolase (

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