Relevant bibliographies by topics / Effects of xenobiotics on the kidney

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Effects of xenobiotics on the kidney'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Effects of xenobiotics on the kidney.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Effects of xenobiotics on the kidney"

1

Hannan, Md Abdul, Md Sarwar Zahan, Partha Protim Sarker, Akhi Moni, Hunjoo Ha, and Md Jamal Uddin. "Protective Effects of Black Cumin (Nigella sativa) and Its Bioactive Constituent, Thymoquinone against Kidney Injury: An Aspect on Pharmacological Insights." International Journal of Molecular Sciences 22, no. 16 (August 23, 2021): 9078. http://dx.doi.org/10.3390/ijms22169078.

Full text
Abstract:
The prevalence of chronic kidney disease (CKD) is increasing worldwide, and a close association between acute kidney injury (AKI) and CKD has recently been identified. Black cumin (Nigella sativa) has been shown to be effective in treating various kidney diseases. Accumulating evidence shows that black cumin and its vital compound, thymoquinone (TQ), can protect against kidney injury caused by various xenobiotics, namely chemotherapeutic agents, heavy metals, pesticides, and other environmental chemicals. Black cumin can also protect the kidneys from ischemic shock. The mechanisms underlying the kidney protective potential of black cumin and TQ include antioxidation, anti-inflammation, anti-apoptosis, and antifibrosis which are manifested in their regulatory role in the antioxidant defense system, NF-κB signaling, caspase pathways, and TGF-β signaling. In clinical trials, black seed oil was shown to normalize blood and urine parameters and improve disease outcomes in advanced CKD patients. While black cumin and its products have shown promising kidney protective effects, information on nanoparticle-guided targeted delivery into kidney is still lacking. Moreover, the clinical evidence on this natural product is not sufficient to recommend it to CKD patients. This review provides insightful information on the pharmacological benefits of black cumin and TQ against kidney damage.
APA, Harvard, Vancouver, ISO, and other styles
2

Меликова, E. Melikova, Брин, and Vadim Brin. "The Effects of Ammonium Molybdate on Renal Function in the Rats after Parathyreoidectomy." Journal of New Medical Technologies 20, no. 4 (December 20, 2013): 71–73. http://dx.doi.org/10.12737/2733.

Full text
Abstract:
The constant pollution of the environment increases the content of xenobiotics in the air, soil, water and contributes to their entry into the organism. Increased content of molybdenum in the environment has pathogenic effect on the human organism. It is known that the excretion of metals is mainly via the kidney, while the content of the xenobiotics in the urine may have pathogenic effects on renal function. It is of interest to study the renal functions in conditions of inflow metals in the organism. The aim of this work was to study the effect of experimental hypocalcaemia on uropoisis renal function at the chronic molybdenum intoxication. Materials and methods. Experiments were carried out on Wistar-rats. Chronic molybdenum intoxication in experimental animals was caused by intragastric injection of ammonium molybdate solution in the dose of 50mg/kg. during 1 month. Experimental hypocalcaemia was created by the parathyroidectomy. Results. It was noted that when a stand-alone injection of ammonium molybdate glomerular filtration rate is reduced. In the model combined with parathyroidectomy this indicator comes back to normal. Tubular water reabsorption, urinary excretion of calcium and protein are less pronounced than in the isolated introduction ammonium molybdate. Urine osmolarity also had a tendency to decrease. Conclusions. Experimental hypocalcaemia reduces the renal manifestations of chronic molybdenum intoxication.
APA, Harvard, Vancouver, ISO, and other styles
3

Moniruzzaman, M., MM Khan, MK Rahman, and MS Islam. "Effects of profenofos induced histopathology and recovery patterns in silver barb (Barbonymus gonionotus)." Progressive Agriculture 28, no. 3 (November 24, 2017): 240–48. http://dx.doi.org/10.3329/pa.v28i3.34661.

Full text
Abstract:
Histopathology is promising field for research in aquatic toxicology as it provides the real picture of the toxic effects of xenobiotics in vital functions of a living organism. The present study aims to evaluate the toxic effect of pesticide namely profenofos on silver barb. Liver and kidney of silver barb were examined histologically after exposure to sublethal concentrations (0.01 ppm, 10% of LC50 and 0.05 ppm, 50% of LC50) of profenofos for 0, 7, 15 and 30 days. Histological recovery was also studied by maintaining the pesticide‐exposed fish in a freshwater system for an additional 7, 15 and 30 day. Kidney and liver of exposed individuals exhibited some remarkable changes in their histology in comparison to control and recovery group. Hepatic lesions in the liver tissues of fish were characterized by cloudy swelling of hepatocytes, lipoid vacuoles, pycnotic nuclei and focal necrosis. Epithelial hypertrophy, narrowing of the tubular lumen, atrophy of the glomerulus, broader Bowman's capsule, necrosis in the epithelial cells and pycnosis in the hematopoietic tissue were observed in kidney tissues of experimental fish. These lesions grew with increasing concentration. Although some of the changes were reversible, the rest were less pronounced after a recovery period.Progressive Agriculture 28 (3): 240-248, 2017
APA, Harvard, Vancouver, ISO, and other styles
4

Veiga-Matos, Jéssica, Fernando Remião, and Ana Motales. "Pharmacokinetics and Toxicokinetics Roles of Membrane Transporters at Kidney Level." Journal of Pharmacy & Pharmaceutical Sciences 23 (September 29, 2020): 333–56. http://dx.doi.org/10.18433/jpps30865.

Full text
Abstract:
Transporters are large membrane proteins, which control the passage of various compounds through biological membranes. These proteins are divided into uptake and efflux transporters and play an important role in the toxicokinetics of many endobiotics and xenobiotics. The uptake transporters facilitate the absorption of these compounds from the blood into the proximal tubular cells, while the efflux transporters eliminate these compounds into tubular fluid (urine). Overall, the uptake is performed by the superfamily solute carrier (SLC) transporters, which are, mostly, located in the basolateral membrane. The organic anion transporters (OATs; SLC22), the organic cation transporters (OCTs; SLC22), the organic cation/carnitine transporters (OCTNs), and the organic anion transporting polypeptides (OATP; SLC21/SLCO) are some examples of uptake transporters of the SLC superfamily. On the other hand, the superfamily ATP-binding cassette (ABC) transporters carry out the elimination of the substances through the apical membrane of the proximal tubular cells. The multidrug resistance proteins 1 (MDR; ABCB), the multi resistance protein (MRP2; ABCC) and the breast cancer resistance protein (BCRP, ABCG) along with the multidrug and toxin extrusion (MATE), which is an SLC transporter, carry out the substance efflux of the cell, However, uptake transporters seem to be more efficient than efflux transporters, leading to an accumulation of compounds in proximal tubular cells and, consequently, to renal damage. The accumulation of compounds can also occur due to variations in the number of transporters that exist due to differences in sex, age, genetic polymorphisms and epigenetics. Furthermore, some substances can inhibit, induce or, eventually, activate these transporters, with consequent drug-drug interactions (DDIs) as a result of alterations on the toxicokinetics of xenobiotics, leading to an increase of their accumulation and, consequently, to renal damage. These compounds may be exogenous, such as antibiotics, antivirals, cisplatin, metals, herbicides, mycotoxins and drugs; or endogenous, like uric acid, bile acids, bilirubin conjugates and conjugated steroids. Thus, in this review, we will focus on the accumulation of exogenous compounds due to variations on renal transporters and the consequent biological effects caused by them.
APA, Harvard, Vancouver, ISO, and other styles
5

Benourad, Fouzia, Zehra-Cagla Kahvecioglu, Mokhtar Youcef-Benkada, and Jean-Marie Colet. "Protective potential of the essential oil of Thymus vulgaris L. against Dicofol-induced poisoning in rats as established through clinical chemistry, histopathology and 1H-NMR-based metabonomics." South Asian Journal of Experimental Biology 8, no. 2 (January 14, 2019): 49–56. http://dx.doi.org/10.38150/sajeb.8(2).p49-56.

Full text
Abstract:
Pesticides, organochlorines, analogues and derivatives of DDT, those are all terms often associated with health risks, intoxications, nephropathies and other hepatotoxicities. These are phytosanitary products that interfere with the internal metabolism of sensitive organs, such as the kidney or the liver, which orchestrate the metabolism and elimina on of xenobiotics. In this study, a group of Wistar rats was intraperitoneally exposed to Dicofol, a pesticide analogue of DDT. A second group received preven ve injec ons of a diluted thyme essen al oil solu on for four days before exposure to Dicofol. The evaluation of the toxic effects possibly induced by Dicofol in the two experimental groups was carried out using a mul disciplinary approach in- cluding clinical chemistry, histopathology and 1H-NMR-based metabonomics. Histopathological examina on showed pulmonary in amma on and kidney damage in the group exposed to Dicofol. The metabonomic study revealed metabolic disturbances in the liver and kidney. The protective role of the essential oil of thyme was clearly demonstrated from the metabonomic profiles and was confirmed by histological examina on of organs.
APA, Harvard, Vancouver, ISO, and other styles
6

Ilina, E. N., E. M. Mayorova, A. I. Manolov, A. A. Korenkova, V. V. Bahmetjev, and K. S. Gorbunov. "Gut Microbiome and Drug Metabolism." Biomedical Chemistry: Research and Methods 4, no. 1 (January 2021): e00146. http://dx.doi.org/10.18097/bmcrm00146.

Full text
Abstract:
The human physiology textbooks traditionally consider the intestine as a metabolically active organ, with its activity primarily associated with the production of numerous digestive enzymes. The development of molecular analysis technologies has significantly detailized this picture, primarily by decoding the metabolic potential of the intestinal microbiota. Data from numerous metagenomic studies indicate that the number of eukaryotic and bacterial cells in the human body is comparable - about 3.0×1013, while the number of genes in the intestinal metagenome is one hundred times greater than in the human genome. Obviously, the gut microbiota exhibits both direct and indirect effects on the metabolism of drugs and xenobiotics, that can affect their effectiveness and toxicity. Orally administrated xenobiotics have been found to be metabolized by intestinal microbial enzymes before being absorbed from the gastrointestinal tract into the blood flow. The metabolic reactions performed by the gut microbiota greatly differ from the metabolic reactions of the liver, providing modification of drugs by acetylation, deacetylation, decarboxylation, dehydroxylation, demethylation, dehalogenation, etc. Despite the metabolism of xenobiotics by microbial enzymes of the intestine is rather known, information about the specific microflora mediating each metabolic reaction is still limited, mainly by the lack of an adequate model of the intestinal microbial community to allow the accumulation of experimental data for the creation of computational models. Currently, studies of drug metabolism use microfluidic chips, reproducing functions of various organs and tissues, such as the liver, kidney, lungs and intestine, as in vitro models in the form of 2D and 3D cell cultures. Supplementation of such systems with the microbial community will allow to get as close as possible to in vitro modeling of complicated biological processes in the interests of pharmacological research and the accumulation of data for constructing computational models.
APA, Harvard, Vancouver, ISO, and other styles
7

Politis, Maria D., Jacob C. Freedman, Erin N. Haynes, and Alison P. Sanders. "Association of Manganese Biomarker Concentrations with Blood Pressure and Kidney Parameters among Healthy Adolescents: NHANES 2013–2018." Children 8, no. 10 (September 25, 2021): 846. http://dx.doi.org/10.3390/children8100846.

Full text
Abstract:
Deficiency or excess exposure to manganese (Mn), an essential mineral, may have potentially adverse health effects. The kidneys are a major organ of Mn site-specific toxicity because of their unique role in filtration, metabolism, and excretion of xenobiotics. We hypothesized that Mn concentrations were associated with poorer blood pressure (BP) and kidney parameters such as estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), and albumin creatinine ratio (ACR). We conducted a cross-sectional analysis of 1931 healthy U.S. adolescents aged 12–19 years participating in National Health and Nutrition Examination Survey cycles 2013–2014, 2015–2016, and 2017–2018. Blood and urine Mn concentrations were measured using inductively coupled plasma mass spectrometry. Systolic and diastolic BP were calculated as the average of available readings. eGFR was calculated from serum creatinine using the Bedside Schwartz equation. We performed multiple linear regression, adjusting for age, sex, body mass index, race/ethnicity, and poverty income ratio. We observed null relationships between blood Mn concentrations with eGFR, ACR, BUN, and BP. In a subset of 691 participants, we observed that a 10-fold increase in urine Mn was associated with a 16.4 mL/min higher eGFR (95% Confidence Interval: 11.1, 21.7). These exploratory findings should be interpreted cautiously and warrant investigation in longitudinal studies.
APA, Harvard, Vancouver, ISO, and other styles
8

AIGNER, Achim, Martina JÄGER, Ralf PASTERNACK, Peter WEBER, Dirk WIENKE, and Sabine WOLF. "Purification and characterization of cysteine-S-conjugate N-acetyltransferase from pig kidney." Biochemical Journal 317, no. 1 (July 1, 1996): 213–18. http://dx.doi.org/10.1042/bj3170213.

Full text
Abstract:
Microsomal cysteine-S-conjugate N-acetyltransferase catalyses the N-acetylation of various S-substituted cysteines in liver and kidney. We describe here the purification and more detailed characterization of this enzyme catalysing the final reaction of mercapturic acid biosynthesis, and thus playing a crucial role in the detoxicating metabolism of many xenobiotics. The solubilization of cysteine-S-conjugate N-acetyltransferase by deoxy-BIGCHAP [N,N´-bis-(3-d-gluconamidopropyl)deoxycholamide] was the prerequisite for partial purification by means of anion-exchange chromatography. The molecular mass of the enzyme was determined by gel filtration. A polyclonal antiserum was raised against the excised protein band from SDS/PAGE and purified antibodies were used for the complete purification of native cysteine-S-conjugate N-acetyltransferase by immunoaffinity chromatography. A dimeric form of the enzyme was sometimes detected on SDS/PAGE, depending on the degree of purification. For further characterization of cysteine-S-conjugate N-acetyltransferase, the stability of catalytic activity, the pH optimum and Km values were determined. The inhibitory effects of various agents were tested, revealing a substantial, yet not complete, loss of cysteine-S-conjugate N-acetyltransferase activity after treatment with cysteine proteinase inhibitors or probenecid under various conditions.
APA, Harvard, Vancouver, ISO, and other styles
9

Bakour, Meryem, Nawal Hammas, Hassan Laaroussi, Driss Ousaaid, Hinde EL Fatemi, Abderrazak Aboulghazi, Najoua Soulo, and Badiaa Lyoussi. "Moroccan Bee Bread Improves Biochemical and Histological Changes of the Brain, Liver, and Kidneys Induced by Titanium Dioxide Nanoparticles." BioMed Research International 2021 (June 23, 2021): 1–13. http://dx.doi.org/10.1155/2021/6632128.

Full text
Abstract:
Titanium dioxide nanoparticles (TiO2) were used in various fields such as food industry, cosmetics, medicine, and agriculture. Despite the many advantages of nanotechnology, the adverse effects of nanoparticles are inevitable. The present study was conducted to evaluate the protective effect of bee bread on titanium dioxide (TiO2) nanoparticle toxicity. Male rats were randomly divided into four groups: Group 1 received daily by gavage (10 mL/kg bw) of distilled water, Group 2 received bee bread ethanolic extract (100 mg/kg bw), Group 3 received TiO2 (100 mg/kg bw) and distilled water (10 mL/kg bw), and Group 4 received TiO2 (100 mg/kg bw) and bee bread ethanolic extract (100 mg/kg bw). All treatments were given daily by gavage during 30 days. At the end of the experiment period, blood samples were collected to analyze fasting blood glucose, lipid profile (TC, TG, LDL-C, HDL-C, and VLDL-C), liver enzymes (AST, ALT, and LDH), total protein, urea, albumin, creatinine, sodium, potassium, and chloride ions. In addition, histological examinations of the kidneys, liver, and brain were investigated. The results showed that the subacute administration of TiO2 alone (100 mg/kg bw) had induced hyperglycemia (309 ± 5 mg/dL) and elevation of hepatic enzyme levels, accompanied by a change in both lipid profile and renal biomarkers as well as induced congestion and dilatation in the hepatic central vein and congestion in kidney and brain tissues. However, the cotreatment with bee bread extract restored these biochemical parameters and attenuated the deleterious effects of titanium nanoparticles on brain, liver, and kidney functions which could be due to its rich content on functional molecules. The findings of this paper could make an important contribution to the field of using bee bread as a detoxifying agent against titanium dioxide nanoparticles and other xenobiotics.
APA, Harvard, Vancouver, ISO, and other styles
10

Watanabe, Atsushi, Takeshi Marumo, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Kohei Ueda, Daigoro Hirohama, et al. "Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney." American Journal of Physiology-Renal Physiology 314, no. 4 (April 1, 2018): F551—F560. http://dx.doi.org/10.1152/ajprenal.00390.2017.

Full text
Abstract:
Epigenetic abnormalities have been suggested to mediate metabolic memory observed in diabetic complications. We have shown that epigenetic alterations may induce persistent phenotypic changes in the proximal tubules of the diabetic kidneys. In this study, we show that pregnane X receptor (PXR), a xenobiotic nuclear receptor, is epigenetically altered and upregulated and may have a possible function in the diabetic kidney. PXR has been shown to play a critical role in metabolic changes in obesity and diabetes; however, its distribution and function in the kidney are unknown. In the normal kidney, Pxr was selectively expressed in the proximal tubular cells with demethylation in the promoter DNA. In db/db mice, significant increases in Pxr mRNA, further demethylation of DNA, and stimulatory histone marks in the promoter were observed. Epigenetic changes are likely to play a causative role in PXR induction, since a DNA methyltransferase inhibitor increased PXR mRNA in cultured human proximal tubular cells. Administration of a PXR agonist increased mRNA levels of solute carrier organic anion transporter family member 2B1 ( Slco2b1), a xenobiotic transporter; response gene to complement 32 ( Rgc32), a molecule known to exert fibrotic effects in the kidney; and phosphoenolpyruvate carboxykinase 1 ( Pck1), a gluconeogenic enzyme in the kidney. The expressions of these genes were inhibited by PXR small interfering RNA in cultured proximal tubular cells. Increased mRNA levels of Slco2b1, Rgc32, and Pck1 were also observed in the kidney of db/db mice. These data indicate that PXR is upregulated in the diabetic kidney with aberrant epigenetic modifications and may modulate the course of diabetic kidney disease through the activation of these genes.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Effects of xenobiotics on the kidney"

1

Cockburn, Elinor M. "The relevance of prostanoid metabolism in the development of drug-induced nephrotoxicity." Thesis, University of Aberdeen, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481095.

Full text
Abstract:
The enzymes prostaglandin synthetase (PGS) and lipoxygenase can cooxidise a variety of xenobiotics to reactive intermediates during the metabolism of arachidonic acid (AA). PGS exhibited a gradient of activity within the kidney which was greatest in the papilla and least in the cortex. Rabbit and rat renal microsomes metabolised the model compound, tetramethylphenylenediamine (TMPD), in the presence of AA by pathways which were predominantly PGS and lipoxygenase-dependent, respectively. Therefore, both enxymes may play a role in the development of site-specific nephrotoxicity within the kidney. The model papillotoxin 2-bromoethanamine (2-BEA) which exhibits target selective toxicity for the renal papilla, was found to be significantly more toxic to medullary interstitial cells than to proximal tubule cells in culture. Toxicity was enhanced significantly by AA whereas inhibitors of cyclooxygenase (indomethacin, aspirin), prostaglandin hydroperoxidase (propylthiouracyl) and lipoxygenase (nordihydrogauaretic acid) all significantly decreased 2-BEA toxicity. This suggests that toxicity is mediated either by the hydroperoxidase component of PGS or by lipoxygenase. Thromboxane A2 (TxA2) is thought to play a pivotal role in cyclosporin A (CsA) induced nephrotoxicity. Administration of a thromboxane synthetase inhibitor (TSI) normalised TxB2 excretion but only partially protected against other factors involved. However, treatment with angiotensin converting enzyme inhibitor either alone or in combination with TSI did not affect CsA nephrotoxicity. Tubular toxicity, manifest as N-acetyl-β-D-glucosaminidase (NAG) enzymuria, glycosuria, vacuolation, calcification and chronic tubule damage, may contribute to the CsA-induced reduction in renal function. In addition to protecting against CsA-induced nephrotoxicity, the administration of TSI to CsA-treated rats also partially reversed pre-existing renal damage.
APA, Harvard, Vancouver, ISO, and other styles
2

Ferreira, Nuno Gonçalo de Carvalho. "The effects of xenobiotics in biomarkers of porcellionides pruinosus." Master's thesis, Universidade de Aveiro, 2009. http://hdl.handle.net/10773/868.

Full text
Abstract:
Mestrado em Toxicologia e Ecotoxicologia
A enorme quantidade de contaminantes quer produzidos pelo Homem (p.e. PHAs, pesticidas, organofosfatos, organocloretos, PBDEs), quer presentes na natureza (p.e. metais) tem um efeito significativamente adverso nos organimos encontrados no meio ambiente. Nos últimos anos, vários biomarcadores têm sido usados na avaliação do efeito de contaminantes no meio ambiente, contudo quase nenhuma informação se centrou no uso desta ferramenta em organismos detritívoros como os isópodes. As reservas energéticas (açucares, lipidos e proteínas) são essenciais para os requisitos de manutenção, crescimento e reprodução de qualquer organismo. As reservas energéticas juntamente com os parâmetros actividade dos sistema de transporte de electrões (STE) e alocação de energia celular (AEC) podem fornecer-nos informação sobre a condição dos organismos quando afectados por contaminantes. Organismos de solo, com o isópode Porcellionides pruinosus, são essenciais para o bom funcionamento dos ecossistemas. Como macrodecompositores, alimentando-se principalmente de matéria vegetal morta, têm um papel importante na cadeia detritívora, através da fragmentação do húmus e pela estimulação e/ou ingestão de fungos e bactérias. São, por isso, organismos importantes na reciclagem de nutrientes. O uso destas espécies chave, juntamente com biomarcadores e conteúdos energéticos poderá ser uma boa ferramenta na avaliação de risco ambiental (ARA). Neste estudo foi avaliado o efeito dos contaminantes zinco e diazinão fornecido por exposição a comida contaminada no isópode Porcellionides pruinosus (Brandt 1833). O estudo baseou-se principalmente no padrão observado nos biomarcadores e nas reservas energéticas para dois tempos de exposição e duas concentrações, já posteriormente descritas como provocando nenhum efeito ou pouco efeito.(5.5 mg zinco/g folha seca, 9.5 mg zinco/g folha seca e de 17.5 μg diazinão/g folha seca, 175 μg diazinão/g folha seca, respectivamente). Para os biomarcadores o tempo de exposição foi de 96h e 7 dias e para as reservas energéticas foi de 7 dias e 14 dias. Os biomarcadores testados foram a acetilcolinesterase (ACHE), lactato desidrogenase (LDH), glutationa S-transferase (GST), glutationa peroxidase (GPx), catalase (CAT) e peroxidação lipídica (LPO). As reservas e conteúdos energéticos medidos foram açúcares, lipidos, proteínas, STE e AEC. Para a exposição a zinco, os biomarcadores GST, CAT e LPO parecem corresponder aos resultados obtidos em outros trabalhos. As reservas energéticas afectadas com uma diminuição significativa foram os açúcares, apresentando também um decréscimo nos valores de ETS e CEA. A exposição a diazinão apresentou diferenças significativas apenas para a ACHE, não apresentado nenhum dos outros biomarcadores alterações de padrões na sua actividade, excepto a GPx para um tempo de exposição de 14 dias. Os lipidos e açúcares foram afectados pela exposição a diazinão e verificou-se também uma diminuição na AEC. ABSTRACT: The enormous amount of contaminants produced by man (i.e. PAHs, pesticides, organophosphates, organochlorides, PBDEs), or that can be found in nature (i.e. metals) has a significant adverse effect on organisms present in the environment. In recent years the biomarkers have been used to evaluate the effects of these contaminants in the environment, but few data has been focused on this assessment tool using detritivorous key-organisms like isopods. Energy reserves (carbohydrates, lipids and proteins) are important for the maintenance, growth and reproduction requirements of any organism. Energy reserves along with the electron transport system activity (ETS) and with the cellular energy allocation (CEA) can give us information about the organisms “status” when affected by the contaminants. Soil key-dwelling organisms like the isopod Porcellionides pruinosus, are essential to the ecosystems’ functions. As macrodecomposers (feeding mainly on decaying plant material) they play an important role in the detritus food chain, through litter fragmentation and stimulating and/or ingesting fungi and bacteria that are important in the cycling of nutrients. The use of these key species along with biomarkers and energy budgets can be a good environmental risk assessment (ERA) endpoint In this work the effects of two environmental contaminants (zinc and diazinon) through food exposure were studied using the isopod Porcellionides pruinosus (Brandt 1833). The study is mainly focused on the effect patterns observed for the biomarkers and energy reserves for two time exposure and two concentrations presented as NOEC and LOEC on previous studies(5.5 μg zinc/g dry leaf, 9.5 μg zinc/g dry leaf and 17.5μg diazinon/g dry leaf, 175μg diazinon/g dry leaf respectively). For biomarkers the exposure time was 96h and 7-days, as for the energy reserves was 7-days and 14-days. The biomarkers tested were acetylcholinesterase (AChE), lactate dehydrogenase (LDH), glutathione S-transferase (GST), glutathione peroxidase (GPx), catalase (CAT) and lipid peroxidation (LPO). The energy reserves and budget tested were: carbohydrates, lipids, proteins, electrons transport system activity (ETS) and cellular energy allocation (CEA). For zinc exposure the biomarkers GST, CAT and LPO seem to correlate with results obtained for other works. The energy reserves affected were the cabohydrates with significant decrease in their content along with a decrease in both ETS and CEA. The diazinon exposure showed only significative results for AChE, with no changes in all the other biomarkers activity, except the GPx for a 14-day exposure. The energy reserves were affect by a decrease in the carbohydrate and lipid content along with a decrease in the CEA.
APA, Harvard, Vancouver, ISO, and other styles
3

Almeida, Ana Rita Marques. "Combined effects of ultraviolet radiation and xenobiotics on zebrafish." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12624.

Full text
Abstract:
Mestrado em Biologia Aplicada - Microbiologia Clínica e Ambiental
Nowadays, climate changes are an imperative problem and multiple measurements made in the last years showed an increase of all wavelengths of solar radiance, specially the Ultraviolet radiation. In their natural environment organisms are not only affected by biotic and environmental factors, but also by abiotic factors such as xenobiotics. Besides, these both stressors can interact with each other being their combined effect unpredictable (producing additive, synergistic or antagonistic effect). This work aims to studying the combined effect of UV radiation and three xenobiotics: triclosan, potassium dichromate and prochloraz on zebrafish embryos (Danio rerio). Effects were assessed at two levels: i) effects on embryos mortality and ii) effects in the natural bacterial communities of zebrafish embryos. The organisms were exposed to concentrations of each chemical combined with several UV doses. Embryo’ mortality, were observed daily for 96 hours post fertilization (hpf) and natural bacterial communities’ evaluation was performed at 48 hpf. Results showed that different combined effect may occur compromising organism’s survival. Combined exposure of UV radiation with TCS revealed a synergism pattern when the UV radiation is the dominant stressor while PD and PCZ revealed antagonism at low dose levels or when the UV radiation is dominant in the mixture. Zebrafish natural bacterial communities were also affected by UV radiation and chemicals with the change of their structure; however, conclusions about interactive effects were difficult to be drawn because effects were not always translated into changes in the diversity indexes.
Hoje em dia, as alterações climáticas são um problema imperativo e múltiplas medições feitas nos últimos anos mostram um aumento de toda a radiação solar, especialmente a radiação Ultravioleta que chega á superfície da terra afetando todos os organismos expostos. No seu ambiente natural, os organismos não estão apenas sujeitos a fatores bióticos, mas também a fatores ambientais e abióticos como por exemplo os xenobióticos. Além disso, ambos os stressores podem interagir uns com os outros produzindo efeitos imprevisíveis nos organismos (efeitos sinergísticos ou antagonísticos). O presente trabalho tem como objetivo a avaliação dos efeitos combinados da radiação UV e três xenobioticos (triclosan, dicromato de potássio e procloraz) em embriões de peixe zebra (Danio rerio). A avaliação foi feita a dois níveis: i) efeitos na mortalidade de embriões e ii) efeitos a nível das comunidades bacterianas naturais dos embriões. Os organismos foram expostos a várias concentrações de cada químico, combinadas com várias doses de UV. A mortalidade foi registada diariamente durante 96 horas e as comunidades bacterianas naturais foram avaliadas às 48 horas pós fertilização (hpf). Os resultados mostram que diferentes efeitos combinados foram observados, alterando a ecotoxicidade esperada. A exposição combinada da radiação UV com o TCS revelou um patrão sinergístico quando a radiação UV é o stressor dominante, enquanto que, na combinação UV com PD e PCZ observou-se antagonismo a doses baixas ou quando a radiação UV era dominante na mistura. As comunidades bacterianas naturais do peixe zebra também foram afetadas pela radiação UV e químicos, com alterações na sua estrutura. No entanto, foi difícil tirar conclusões relativamente a possíveis interações entre stressors visto que os efeitos observados nem sempre se traduziam em variações no índice de diversidade.
APA, Harvard, Vancouver, ISO, and other styles
4

Kumar, Anila. "A study of the effects of the aminoglycoside antibiotics on a human renal cell line." Thesis, University of Sunderland, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302476.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Bridges, Christine M. "The effects of a chemical stressor on amphibian larvae : individual, population, and species level responses /." free to MU campus, to others for purchase, 1999. http://wwwlib.umi.com/cr/mo/fullcit?p9946247.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Hoyle, Vivienne Rosalind. "NMR studies on the biochemical effects of cytochrome P450 inducers and aldose reductase inhibitors." Thesis, Birkbeck (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296524.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Shabir, Shazia. "Indirect effects of cytomegalovirus in kidney transplantation." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7910/.

Full text
Abstract:
Cytomegalovirus (CMV) infection is the most frequent and significant opportunistic infection in kidney transplant recipients. It is associated with direct (CMV disease) and indirect (rejection, poor graft survival) effects with resultant increases in morbidity and mortality. The mechanisms responsible for the indirect effects of CMV infection remain unclear. In this thesis, the indirect effects of cytomegalovirus infection in kidney transplantation are studied. Firstly, the mechanism of CMV infection is investigated. Secondly, the mechanism of CMV associated kidney transplant damage is explored. Thirdly, an assessment for the role of CMV in causing immunosenescence within the kidney transplantation cohort is undertaken. This thesis provides previously undescribed and direct evidence of immune hypo- responsiveness to latent CMV. I have shown CD4⁺CD27⁻CD28^null cells are pathognomonic of prior CMV exposure and have a role in glomerular endothelial cell damage, an effect which may be mediated by NKG2D. Higher CD4⁺CD27⁻CD28^null cell counts at 12 months post-transplantation predict a steeper decline in kidney allograft function thereafter. I provide novel insight into the ‘indirect’ effect of CMV in the pathogenesis of CD8⁺CD28^null cells. My study is the first to demonstrate a temporal association between elevated CD8⁺CD28^null cell frequencies and subsequent development of clinically relevant episodes of infection. The findings from this thesis set the scene for future interventional research and therapeutic strategies.
APA, Harvard, Vancouver, ISO, and other styles
8

Danturti, Sreedevi. "Effects of Adiponectin in Heart and Kidney Transplants." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1483726662977129.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Eyambe, George Sona. "Cellular Biomarkers for Measuring Toxicity of Xenobiotics: Effects of PCBs on Earthworm Lumbricus Terrestris Coelomocytes." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc332716/.

Full text
Abstract:
The research presented herein provides information on coelomocyte (leukocyte) collection, function and immunotoxicity from polychlorinated biphenyls (PCB) in the earthworm Lumbricus terrestris. Research was undertaken as part of an overall goal to develop a well-documented and scientifically valid non-mammalian surrogate immunoassay with the earthworm Lumbricus terrestris to assess immunotoxic potential of xenobiotics. The principal objectives were to: (1) Develop an extrusion model for analyzing immunotoxicity of xenobiotics; (2) determine if coelomocytes can be collected repeatedly without obvious harm to the earthworm or change in immune response of the coelomocytes harvested and (3) validate the response sensitivity profiles of a panel of biomarkers {differential and total cell counts, erythrocyte rosette (ER) and secretory rosette (SR) formation with, and phagocytosis of antigenic rabbit red blood cells} in earthworms after acute exposure to a known mammalian and L. terrestris immunotoxin, the PCB Aroclor 1254.
APA, Harvard, Vancouver, ISO, and other styles
10

Jing, Yu, and n/a. "The acute effects of lithium on the rat kidney." University of Otago. Department of Physiology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20080930.145652.

Full text
Abstract:
The aim of the experiments reported in the present work was: first, to generate a rat model of lithium-induced nephrogenic diabetes insipidus (NDI), and, second, to use this to test the hypothesis that the effects of lithium were far more reaching than merely the inhibition of vasopressin induced translocation and synthesis of the water channel protein AQP2. Specifically, the effect of lithium on the abundance and distribution of the other water channel proteins, AQP1, AQP3 and AQP4 was investigated. It was found that AQP3 protein abundance was significantly reduced in the renal medulla while AQP4 was not affected. In addition, it was further hypothesized that, given the known effects of lithium on the urea transporter UT-A1 and on sodium channels and transporters, the renal medullary osmotic gradient would be dissipated by lithium. This was examined indirectly by determining the amounts of organic osmolytes in the renal medulla of rats with lithium-induced NDI. Myo-inositol was found to be 85 � 9 mmol kg⁻1 protein in the NDI rats, a reduction of 38% compared with control values, sotbitol fell from 35� 9 mmol kg⁻� in the control rats to 2.5 � 0.5 mmol kg⁻�, and glycerophosphorylcholine levels in the experimental animals were 91 � 18 mmol kg⁻� protein compared with 372 � 72 mmol kg⁻� in the controls. In addition, betaine decreased to 38 � 2 mmol kg⁻� protein from 69 � 10 mmol kg⁻� protein in the control. The urea content of the medulla was found to have fallen from 2868 � 558 mmol kg⁻� protein to 480 � 105 mmol kg⁻� protein. These data indicated that indeed the medullary osmotic gradient, the driving force for AVP-dependent fluid reabsorption in the kidney was greatly reduced during lithium-induced NDI. Thirdly, it was proposed that the sodium-channel blocker, amiloride, by acting to prevent lithium entry into the cells of the collecting duct, should ameliorate or abolish the adverse effects of lithium on the kidney. Treatment of rats with established NDI, with amiloride, reversed to a large extent the reduction in aquaporin protein expression and re-established the medullary osmotic gradient, as assessed by the ability of treated rats to concentrate their urine, and by the rise in amounts of medullary osmolytes. Administration of 0.5 mmol l⁻� amiloride to lithium-treated rats led to medullary AQP2 and AQP3 protein abundance increasing by 82% � 16% and 110% � 4% of the control level respectively. The content of urea in the medulla also increased to 2474 � 557 mmol kg⁻� protein. Finally, since in humans it is known that the chronic effect of lithium on the kidney is to cause cortical fibrosis and renal failure, microarray studies were commenced to look for evidence of early changes in gene activity in response to lithium-administration. The results showed that 77 genes were either up- or down-regulated, in particular, genes that are involved in the apoptosis pathway. In the light of these results it is plausible to suggest that the acute renal effects of lithium to induce NDI can be effectively mitigated, and reversed, by administration of amiloride. Whether this can serve to offset the chronic effects of lithium on the kidney awaits further investigation.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Effects of xenobiotics on the kidney"

1

Masters, Noel. The effects of exercise on kidney function. Cardiff: S.G.I.H.E., 1985.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Srinivas, T. R., and Daniel A. Shoskes. Kidney and pancreas transplantation: A practical guide. New York: Humana Press, 2011.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Bari Seminar in Nephrology (3rd 1988). Drugs, systemic diseases, and the kidney. New York: Plenum Press, 1989.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Srinivas, T. R., and Daniel A. Shoskes. Kidney and pancreas transplantation: A practical guide. New York: Humana Press, 2011.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Trang, Hoang. The effects of vitamin D and its receptor in normal subjects and kidney stone formers. Ottawa: National Library of Canada, 1998.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Rietbrock, Norbert. Handbook of renal-independent cardiac glycosides: Pharmacology and clinical pharmacology. Chichester: E. Horwood, 1989.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

M, Hotchkiss Sharon A., ed. Allergic contact dermatitis: Chemical and metabolic mechanisms. London: Taylor & Francis, 2001.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Wu, Xiaoyan. Effects of dietary potassium depletion in salt-dependent hypertension: The kidney, electrolyte balance, and sympathetic nervous system in Dahl rats. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1997.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

V, Wizemann, Kramer W, and Schütterle G, eds. The heart in end-stage renal failure: Etiology, symptoms, and management of uremic heart disease. Basel: Karger, 1986.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Golightly, Larry K. Renal pharmacotherapy: Dosage adjustment of medications eliminated by the kidneys. New York: Springer, 2013.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Effects of xenobiotics on the kidney"

1

Zbinden, G., and L. Grimm. "Thrombogenic Effects of Xenobiotics." In Archives of Toxicology, 131–41. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-69928-3_19.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Vargová, M., M. Gajdová, J. Jakubovský, and L. Wsólová. "Estrogenic Effects of Some Xenobiotics." In Archives of Toxicology, 148–52. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79451-3_12.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

van Henegouwen, G. M. J. Beijersbergen, R. W. Busker, H. de Vries, and S. A. Schoonderwoerd. "Systemic Photobiological Effects of Xenobiotics." In Archives of Toxicology, 60–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73113-6_9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Embrandiri, Asha, S. Katheem Kiyasudeen, Parveen Fatemeh Rupani, and Mahammad Hakimi Ibrahim. "Environmental Xenobiotics and Its Effects on Natural Ecosystem." In Plant Responses to Xenobiotics, 1–18. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-2860-1_1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Batlle, Daniel, Edgar V. Lerma, Parveen Naaz, and Santosh Hakkapakki. "Lithium-associated kidney effects." In Clinical Nephrotoxins, 725–48. Boston, MA: Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-84843-3_31.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Annamalai, Aniyizhai. "Chronic Kidney Disease." In Medical Management of Psychotropic Side Effects, 121–25. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-51026-2_17.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Dawson, Laura A., Anne Horgan, and Eric P. Cohen. "Kidney and Ureter." In ALERT • Adverse Late Effects of Cancer Treatment, 443–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-75863-1_17.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Fleming, Ingrid, and Rudi Busse. "Vascular Effects of NO." In Nitric Oxide and the Kidney, 161–75. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-6039-5_8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Bolek, Richard, and Klaus Kümmerer. "Fate and Effects of Little Investigated Scents in the Aquatic Environment." In Xenobiotics in the Urban Water Cycle, 87–100. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-3509-7_5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Patel, Punam H., and Krista L. Donohoe. "Miscellaneous Drug-related Adverse Effects." In Dermatological Manifestations of Kidney Disease, 211–20. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2395-3_19.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Effects of xenobiotics on the kidney"

1

Kucherenko, S. V. "XENOBIOTICS ATTACK! WHAT TO DO?" In STATE AND DEVELOPMENT PROSPECTS OF AGRIBUSINESS. DSTU-PRINT, 2020. http://dx.doi.org/10.23947/interagro.2020.1.178-180.

Full text
Abstract:
Xenobiotics - substances alien to the body - have become a major problem, since they negatively affect human health. They can directly affect, disrupting vital functions, and can form various metabolites in the body due to transformation. But the main danger of xenobiotics is their bioaccumulation. There are many studies on how to prevent the harmful effects of xenobiotics. This article discusses the main routes of ingestion of these foreign.
APA, Harvard, Vancouver, ISO, and other styles
2

Sedighi, Zeinab, Hossein Ebrahimpour-Komleh, and Seyed Jalaleddin Mousavirad. "Featue selection effects on kidney desease analysis." In 2015 International Congress on Technology, Communication and Knowledge (ICTCK). IEEE, 2015. http://dx.doi.org/10.1109/ictck.2015.7582712.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

STANKEVIČIŪTĖ, Jolanta, Solveiga Marija BARKAUSKAITĖ, and Gediminas BRAZAITIS. "DETECTION OF XENOBIOTIC SUBSTANCES IN MUTE SWANS’ (CYGNUS OLOR) BLOOD." In Rural Development 2015. Aleksandras Stulginskis University, 2015. http://dx.doi.org/10.15544/rd.2015.064.

Full text
Abstract:
During recent years the attention towards the effects of xenobiotic substances on wild nature has been steadily increasing. Literature reviews have revealed that active hormone-disintegrating substances might affect the reproduction of some wild animal species. Research shows anomalies of reproduction and development in various animal groups such as birds, fish, invertebrates and reptiles. Species inhabiting water and its surroundings cause the highest concern. Due to insufficient baseline information it is difficult to determine the extent of the problem in these wild populations on an ecological scale. The research described in this article is the first attempt to analyse xenobiotic substances and evaluate possible accumulation of pharmaceuticals in animals higher up in the food chain in Lithuania. This research tests new methods for to analyse for xenobiotics substances, which might be used in the future. Blood samples of 7 swans were examined using liquid chromatography, however, no xenobiotics were detected. Negative results do not eliminate the necessity for further investigate of larger samples, other species or to search for non-pharmaceutical xenobiotics.
APA, Harvard, Vancouver, ISO, and other styles
4

Huang, Ching-Te, Cheng-Han Tsai, and Chun-Ping Jen. "Effects of Supraphysiological Thermal Injury in Human Embryonic Kidney Cells." In 2008 International Conference on Biomedical Engineering And Informatics (BMEI). IEEE, 2008. http://dx.doi.org/10.1109/bmei.2008.87.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Ndii, Meksianis Z., David Tambaru, and Bertha S. Djahi. "The effects of hard water consumption on kidney-related diseases." In SYMPOSIUM ON BIOMATHEMATICS 2019 (SYMOMATH 2019). AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0023484.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Türedi, Sibel. "Effects of propolis against cisplatin induced experimental kidney damage in rats." In 15th International Congress of Histochemistry and Cytochemistry. Istanbul: LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.op-27.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Gül, Mehmet. "Protective Effects Of Resveratrol and Melatonin On Carbon Tetrachloride Induced Kidney Damage." In 15th International Congress of Histochemistry and Cytochemistry. Istanbul: LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-74.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Balbotkina, Evgeniya, and Taisia Kovaleva. "VEGETATIVE NERVOUS SYSTEM EFFECTS ON KIDNEY SODIUM EXCRETION IN EXCESS NaCl SUPPLY." In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2049.sudak.ns2021-17/73-74.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Kaya, Ozlem Tugce. "The Protective Effects of Dapaglifozin on Experimental Sepsis Induced Kidney Damage in Rats." In 15th International Congress of Histochemistry and Cytochemistry. Istanbul: LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-264.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Tambaru, David, Bertha S. Djahi, and Meksianis Z. Ndii. "The effects of hard water consumption on kidney function: Insights from mathematical modelling." In SYMPOSIUM ON BIOMATHEMATICS (SYMOMATH) 2017. Author(s), 2018. http://dx.doi.org/10.1063/1.5026092.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Effects of xenobiotics on the kidney"

1

Zhao, Jie, Chao Mo, Wei Shi, Lifeng Meng, and Jun Ai. Effects of turmeric/curcumin on diabetic kidney disease: A meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2021. http://dx.doi.org/10.37766/inplasy2021.8.0001.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Brooks, John, Cole Chapman, Manish Suneja, Mary Schroeder, Michelle Fravel, Kathleen Schneider, June Wilwert, et al. Comparing the Effects of a Stroke Medicine in Older Adults With and Without Chronic Kidney Disease. Patient-Centered Outcomes Research Institute (PCORI), April 2020. http://dx.doi.org/10.25302/042020.me.13036011.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Zhang, Yong, Jingjing Li, Anjun Wang, Tian Li, and Yan-Hong Tuo. Effects of intensive blood pressure control on mortality and cardio-renal function in chronic kidney disease patients. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2021. http://dx.doi.org/10.37766/inplasy2021.3.0001.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Zhang, Fan, Yan Bai, Xing Zhao, Ying Zhang, Liuyan Huang, Hui Wang, and Huachun Zhang. Therapeutic effects of exercises for patients with chronic kidney disease: an overview of meta-analyses of clinical trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2020. http://dx.doi.org/10.37766/inplasy2020.7.0049.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Wu, Zijian, Liang Li, Guiling Wu, Youqiong Xie, Jia Li, and Rui Peng. Effects of Tonifying Kidney and Strengthen Bone Therapy on Non-dialysis Patients With Chronic Kidney Disease-Mineral and Bone Disorder: a protocol for the systematic review and meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2020. http://dx.doi.org/10.37766/inplasy2020.12.0086.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Wu, Lihua, Hongmei Lu, Ling Wu, Bo Qu, Yu Liu, and Mingquan Li. Effects of exercise on inflammation and nutrition outcomes in patients with chronic kidney disease: a protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2020. http://dx.doi.org/10.37766/inplasy2020.10.0025.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Chou, Roger, Jesse Wagner, Azrah Y. Ahmed, Ian Blazina, Erika Brodt, David I. Buckley, Tamara P. Cheney, et al. Treatments for Acute Pain: A Systematic Review. Agency for Healthcare Research and Quality (AHRQ), December 2020. http://dx.doi.org/10.23970/ahrqepccer240.

Full text
Abstract:
Objectives. To evaluate the effectiveness and comparative effectiveness of opioid, nonopioid pharmacologic, and nonpharmacologic therapy in patients with specific types of acute pain, including effects on pain, function, quality of life, adverse events, and long-term use of opioids. Data sources. Electronic databases (Ovid® MEDLINE®, PsycINFO®, Embase®, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews) to August 2020, reference lists, and a Federal Register notice. Review methods. Using predefined criteria and dual review, we selected randomized controlled trials (RCTs) of outpatient therapies for eight acute pain conditions: low back pain, neck pain, other musculoskeletal pain, neuropathic pain, postoperative pain following discharge, dental pain (surgical or nonsurgical), pain due to kidney stones, and pain due to sickle cell disease. Meta-analyses were conducted on pharmacologic therapy for dental pain and kidney stone pain, and likelihood of repeat or rescue medication use and adverse events. The magnitude of effects was classified as small, moderate, or large using previously defined criteria, and strength of evidence was assessed. Results. One hundred eighty-three RCTs on the comparative effectiveness of therapies for acute pain were included. Opioid therapy was probably less effective than nonsteroidal anti-inflammatory drugs (NSAIDs) for surgical dental pain and kidney stones, and might be similarly effective as NSAIDs for low back pain. Opioids and NSAIDs were more effective than acetaminophen for surgical dental pain, but opioids were less effective than acetaminophen for kidney stone pain. For postoperative pain, opioids were associated with increased likelihood of repeat or rescue analgesic use, but effects on pain intensity were inconsistent. Being prescribed an opioid for acute low back pain or postoperative pain was associated with increased likelihood of use of opioids at long-term followup versus not being prescribed, based on observational studies. Heat therapy was probably effective for acute low back pain, spinal manipulation might be effective for acute back pain with radiculopathy, acupressure might be effective for acute musculoskeletal pain, an opioid might be effective for acute neuropathic pain, massage might be effective for some types of postoperative pain, and a cervical collar or exercise might be effective for acute neck pain with radiculopathy. Most studies had methodological limitations. Effect sizes were primarily small to moderate for pain, the most commonly evaluated outcome. Opioids were associated with increased risk of short-term adverse events versus NSAIDs or acetaminophen, including any adverse event, nausea, dizziness, and somnolence. Serious adverse events were uncommon for all interventions, but studies were not designed to assess risk of overdose, opioid use disorder, or long-term harms. Evidence on how benefits or harms varied in subgroups was lacking. Conclusions. Opioid therapy was associated with decreased or similar effectiveness as an NSAID for some acute pain conditions, but with increased risk of short-term adverse events. Evidence on nonpharmacological therapies was limited, but heat therapy, spinal manipulation, massage, acupuncture, acupressure, a cervical collar, and exercise were effective for specific acute pain conditions. Research is needed to determine the comparative effectiveness of therapies for sickle cell pain, acute neuropathic pain, neck pain, and management of postoperative pain following discharge; effects of therapies for acute pain on non-pain outcomes; effects of therapies on long-term outcomes, including long-term opioid use; and how benefits and harms of therapies vary in subgroups.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Effects of xenobiotics on the kidney' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography