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1

Goreham, Steve. The mad, mad, mad world of climatism: Mankind and climate change mania. New Lenox Books, 2013.

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2

Hoxter, Holly Nicole. The Snowball Effect. HarperCollins, 2010.

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3

Bornmalm-Jardelöw, Gunilla. Högre utbildning och arbetsmarknad: En studie med tillämpningar på svenska förhållanden. Nationalekonomiska institutionen, Handelshögskolan vid Göteborgs universitet, 1988.

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4

Mitchell, Juliet. Mad men and Medusas: Reclaiming hysteria and the effect of sibling relationships on the human condition. Allen Lane The Penguin Press, 2000.

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5

Mitchell, Juliet. Mad men and Medusas: Reclaiming hysteria and the effect of sibling relationships on the human condition. Allen Lane, 2000.

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6

Gråbacke, Carina. Möten med marknaden: Tre svenska fackförbunds agerande under perioden 1945-1976. Ekonomisk-historiska institutionen vid Göteborgs universitet, 2002.

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7

Klenner, Frederick R. Clinical guide to the use of vitamin C: The clinical experiences of Frederick R. Klenner, M.D. Life Sciences Press, 1991.

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8

Wolf, Preben. Om lokalisering af kriminalitet og kriminelle med henblik på kriminalitetsforebyggende miljøplanlægning og forskning. Kriminalpræventive råd, 1985.

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9

Fischer, William L. Secrets to a healthy heart and low cholesterol: Proven guidelines and documented facts for the natural self-treatment and prevention of heart disease, high cholesterol, and other related ailments in conjunction with the world-famous breakthrough formula by Prof. Flemming Norgaard, M.D., D.D.S. Fischer Pub. Corp., 1993.

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10

Walker, Johnny, James Newton, and Austin Fisher. Mad Max Effect: Road Warriors in International Exploitation Cinema. Bloomsbury Academic & Professional, 2022.

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11

Walker, Johnny, James Newton, and Austin Fisher. Mad Max Effect: Road Warriors in International Exploitation Cinema. Bloomsbury Publishing Plc, 2021.

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12

Stover, Eric, K. Alexa Koenig, and Laurel E. Fletcher. The Cumulative Effect. Edited by Metin Başoğlu. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199374625.003.0012.

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This chapter demonstrates how the US government selectively manipulated the medical and health literatures after the attacks of September 11, 2001 to justify the torture and cruel, inhuman, or degrading treatment of detainees held in US custody. The authors analyze the Department of Justice Office of Legal Counsel’s “Torture Memos” to illustrate the ways in which governments can attempt to circumvent the protections offered by existing definitions of torture, even while claiming to operate within legal limits. The authors offer a stark warning about the ways in which research findings can be p
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13

Woods, Bob, and Gill Windle. The effect of ageing on personality. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199644957.003.0052.

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Ageing and personality interact. Whilst experiences that may be associated with age, including changes in roles and social networks, losses and health challenges, may require adaptation of aspects of personality, personality across the life-span fundamentally influences how ageing is experienced. There are indications that extraversion, conscientiousness and openness show reduced levels in later life, but people’s rank order on personality traits remains stable. Development continues into later life, but builds on earlier experiences and ways of coping. Personality resources such as self-estee
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14

Bhopal, Raj S. Cause and effect: The epidemiological approach. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198739685.003.0005.

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Cause and effect understanding is the highest form of scientific knowledge. In epidemiology, demonstrating causality is difficult because of the long and complex natural history of many human diseases and because of ethical restraints. Epidemiologists should: hold the attitude that all judgements of cause and effect are tentative; understand that causal thinking demands a judgement; be alert for the play of chance, error, and bias; always consider reverse causality and confounding, utilize the power of causal models that broaden causal perspectives; apply guidelines for causality as an aid to
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15

Mans Role in Shaping Eastern Med. Taylor & Francis, 1990.

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16

Bromley, Lesley. The molecular basis for the placebo effect. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0041.

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The landmark paper discussed in this chapter is ‘The neurobiology of placebo analgesia: From endogenous opioids to cholecystokinin’, published by Benedetti and Amanzio in 1997. This major review considered the placebo and nocebo effect in a more scientific framework compared to previous treatise of a nebulous concept whose only role is to act as a comparator for controlled trials. By expounding robust evidence, Benedetti and Amanzio added credence to the placebo effect, with not just psychological but also physiological data, acknowledging it as an effective therapeutic action. Furthermore, th
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17

Jensen, Niels Rosendal, Frank Ebsen, Bente Jensen, and Soren Langager. Handlekompetencer I PAedagogisk Arbejde Med Socialt Udsatte Born Og Unge: - Indsats Og Effekt. Aarhus University Press, 2009.

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18

Jensen, Niels Rosendal, Frank Ebsen, Bente Jensen, and Soren Langager. Handlekompetencer I PAedagogisk Arbejde Med Socialt Udsatte Born Og Unge: - Indsats Og Effekt. Aarhus University Press, 2009.

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19

Publishing, Van Haren. Half Double Metodologiens Foundation Guide: Projekter På Den Halve Tid Med Den Dobbelte Effekt. Van Haren Publishing, 2022.

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20

Wenzel, Ulrich, Thorsten Wiech, and Udo Helmchen. The effect of hypertension on renal vasculature and structure. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0211.

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The concept of hypertensive nephrosclerosis was introduced by Volhard and Fahr in 1914 and has been extensively used in the literature since then, but its existence is controversial. While it is indisputable that malignant hypertension is a cause of end-stage renal disease (ESRD), there remains controversy as to whether the so-called benign nephrosclerosis can also lead to ESRD.Pressure, if it is great enough, will eventually disrupt any structure. Obviously, this is also true of blood pressure. It is therefore not surprising that an experimentally induced great increase in pressure disrupts t
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21

Kinsella, Sinead, and John Holian. The effect of chronic renal failure on critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0218.

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The incidence of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) is increasing, reflecting an increase in the incidence and prevalence of hypertension and type 2 diabetes. Patients with CKD and ESKD frequently experience episodes of critical illness and require treatment in an intensive care unit (ICU)setting. Management requires specific consideration of their renal disease status together with their acute illness. Mortality in critically-ill patients with ESKD is frequently related to their co-morbid conditions, rather than their ESKD status. Illness severity scoring systems
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22

Autenried, Peter *. The effect of cyclosporine and other immunosuppressive agents on systemic MHC expression in the mouse. 1988.

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23

Williams, Andrew D., Robert G. Fassett, Erin J. Howden, and Jeff S. Coombes. Effect of lifestyle modifications on patients with chronic kidney disease. Edited by David J. Goldsmith. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0105_update_001.

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While treatment with pharmacological agents is commonplace, lifestyle management in delaying chronic kidney disease progression should also be provided. These include dietary and exercise interventions, and bariatric surgery for obesity – though this last may have effects in both directions. This chapter describes the effects of lifestyle on chronic kidney disease progression and the research evidence for the use of lifestyle interventions.
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24

Marchand, Serge. The milestone effect of DNIC in our understanding of pain. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0039.

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While thousands of articles are published each year on pain, only a few have such a major impact on the understanding of pain mechanisms as the landmark paper discussed in this chapter; published by Le Bars and colleagues in 1979, it introduced the concept of diffuse noxious inhibitory control (DNIC; also called diffuse noxious inhibition) mechanisms. Although this work is more than three decades old, it still has a major influence on both the understanding of pain mechanisms and the development of clinical approaches. It is known that apparently similar pain may be caused by different mechani
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25

Virkninger av motorferdsel på fauna og vegetasjon: Kunnskapsstatus med relevans for Svalbard. Norsk Polarinstitutt, 2002.

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26

Munar, Myrna Y., and Ali J. Olyaei. The effect of renal failure on drug handling in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0217.

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The kidneys play an important role in the elimination of many drugs. In chronic kidney disease and acute kidney injury several pharmacokinetic processes are altered. Thus, patients with impaired renal function require adjustment of medication dosing. Many drugs require a loading dose to rapidly achieve therapeutic plasma concentrations. Subsequently, the dose or dosing interval may have to be adjusted as appropriate for the degree for renal function. The most common method to estimate renal function is use of the Cockcroft–Gault (CG) equation. It has been well validated, is easy to remember, a
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27

Mad men and Medusas: Reclaiming hysteria and the effect of sibling relationships on the human condition. Penguin, 2000.

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28

Progress Clin Biochem Med (Progress in Clinical Biochemistry and Medicine, Vol 2). Springer, 1985.

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29

Kortgen, Andreas, and Michael Bauer. The effect of acute hepatic failure on drug handling in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0197.

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Impaired hepatic function is a common event in intensive care unit patients and as the liver plays a central role in drug metabolism and excretion this may lead to profound changes in pharmacokinetics. Underlying mechanisms are altered enzyme function of phase I and phase II metabolism, altered transporter protein function together with cholestasis and hepatic perfusion disorders. Moreover, multidrug therapy may lead to induction and inhibition of these enzymes and transporter proteins. In addition, changes in plasma protein binding and volumes of distribution of drugs are common. Altogether,
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30

Laycock, Helen. Nocebo and its importance in clinical practice. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0045.

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The landmark paper discussed in this chapter is ‘When words are painful: unravelling the mechanism of the nocebo effect’, published in 2007 by Benedetti et al. This major review considered the placebo and nocebo effect in a more scientific framework compared to the previous nebulous concept of a placebo as an agent whose only role is was to act as a comparator for controlled trials. By expounding robust evidence, Benedetti added credence to the placebo effect with not just psychological but physiological data acknowledging it as an effective therapeutic action. Furthermore the importance of en
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31

Abhishek, Abhishek, and Michael Doherty. Placebo, nocebo, and contextual effects. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0027.

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Placebo effect is an example of ‘contextual’ effect and is the symptomatic improvement experienced by patients who have unknowingly received a placebo (inactive treatment) instead of an active drug. It occurs due to patient-specific factors such as expectation of improvement and is influenced by the context in which the treatment is delivered. Nocebo effect is the opposite of placebo effect and includes worsening of symptoms or incident adverse effects due to expectancy or negative contextual or practitioner influence. Placebo effect has been demonstrated in a range of musculoskeletal conditio
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32

Dumbauld, Brett R. Thalassinid shrimp ecology and the use of carbaryl to control populations on oyster ground in Washington coastal estuaries. 1994.

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33

Ellis, Kathryn. A Brief Overview of the Effect of War Injuries on Sexual Health and Intimacy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190461508.003.0001.

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This chapter establishes definitions of sexual health and intimacy, provides insight into how they interact and affect successful relationships, and communicates the importance of addressing the sexual and intimacy needs of injured service members and their partners. Common deployment-related diagnoses, including post-traumatic stress disorder, traumatic brain injury, orthopedic injuries, spinal cord injuries, genital injuries, burns, and facial injuries, and their possible corresponding limitations are reviewed, along with how such limitations can result in sexual avoidance and intimacy avoid
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34

De Silva, Mary J., Alex Cohen, and Vikram Patel. Evaluation of interventions in the real world. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199680467.003.0016.

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The goal of global mental health trials is to generate knowledge that can be implemented in the much messier ‘real world’. However, the effect of interventions in the real world may be different from, and most likely much smaller than, the effect sizes reported in trials. It is therefore essential that we evaluate their implementation and effect when they are ‘scaled-up’ as real programmes. The evaluation of scaled-up health programmes typically involves the use of multiple methods which are triangulated to address the key questions of the programme leaders or investigators. This chapter aims
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35

Hurd, Barbara. Stirring the Mud: On Swamps, Bogs and Human Imagination. Beacon Press, 2001.

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36

Hurd, Barbara. Stirring the Mud: On Swamps, Bogs, and the Human Imagination. Beacon Press, 2002.

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37

Gordon, David, Ahmad Khattab, and Magdalena Anitescu. Bupivacaine and Glucocorticoid-Induced Myonecrosis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190271787.003.0035.

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The most frequently used medications for chronic pain are local anesthetics (LA) and glucocorticoids. Common adverse events from LA, such as seizures and cardiotoxicity, are well known. A lesser known side effect is local tissue reaction to the LA concentration. Myotoxicity is one of the common denominators of direct tissue reaction to LA; it results from the disruption of the mitochondria in the muscle cells. All LA produce some degree of myotoxicity; bupivacaine has the greatest effect and procaine the least. If LA is combined with glucocorticoid, muscle breakdown is even more extensive show
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38

Mahon, Anthony D. Aerobic training. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199232482.003.0039.

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Aerobic training is defined as exercise training that involves whole body endurance activity that is sustained for a sufficient length of time and at a sufficient intensity in order to improve cardiorespiratory fitness.1 The effect of aerobic training on physiological function in children has been investigated for nearly four decades. Some of this research has focused on the health-related benefits of this type of training on children and adolescents and for good reason. With increasing rates of obesity, type 2 diabetes, metabolic syndrome, and many other physical inactivity-related disorders,
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39

Davies, Andrew N. Oral care. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0085.

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Oral problems are common in patients with advanced cancer as well as in other groups of patients with life-limiting illnesses (and more generally in patients with chronic illness). Oral problems may be related to direct (‘anatomical’) effect of the primary disease, indirect (‘physiological’) effect of the primary disease, treatment of the primary disease, direct/indirect effect of a coexisting disease, treatment of the coexisting disease, or combinations of these factors. The successful management of oral problems involves adequate assessment, appropriate treatment, and adequate re-assessment.
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40

Loaiciga, Francisco, and Rony Dev. Parenteral Nutrition in Cancer Patients Undergoing Chemotherapy (DRAFT). Edited by Nathan A. Gray and Thomas W. LeBlanc. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190658618.003.0023.

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The meta-analysis by McGeer investigates the benefits of parenteral nutritional support for patients with cancer undergoing chemotherapy. The study concluded that total parenteral nutrition (TPN) has a detrimental effect (decreased survival and poorer tumor response), with an increased infection risk but no significant effect on hematologic or gastrointestinal toxicity. The authors report a net harm with the use of TPN in patients undergoing chemotherapy and recommend that such interventions should be discouraged. This chapter describes the basics of the study, briefly reviews other relevant s
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41

Malina, Robert M. The influence of physical activity and training on growth and maturation. Edited by Neil Armstrong and Willem van Mechelen. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198757672.003.0032.

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Physical activity in the general youth population and systematic training for sport among young athletes seems to have no effect on size attained and rate of growth in height, or on maturity status and timing. However, activity and training may influence body weight and composition. While both favourably influence bone mineral, variable effects are noted in some sports. Activity has a minimal effect on fatness in normal weight youth, but regular training generally has a positive influence on fatness in youth athletes. Data for fat-free/lean tissue mass are suggestive, but limited. Constitution
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42

McKinlay Gardner, R. J., and David J. Amor. Uniparental Disomy and Disorders of Imprinting. Edited by R. J. McKinlay Gardner and David J. Amor. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199329007.003.0018.

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Uniparental disomy (UPD) is a fascinating pathogenetic mechanism, albeit that it is applicable to a small but important number of conditions. This chapter discusses the basis of UPD and the different mechanisms by which it may arise. It reviews the concept of epigenetics in this setting. This chapter considers UPD as it may have been observed in all the chromosomes, in some of which it appears to be without any effect, and others in which a UPD effect is well known, including the classic UPD conditions, of which Prader-Willi and Angelman syndromes are the archetypes. The differing reproductive
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43

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Vitamins C and E and other antioxidants in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0017.

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Pregnancy is characterized by oxidative stress, wherein high metabolic demands are accompanied by heightened oxygen requirements in tissues. Additionally, a number of disorders of pregnancy are characterized by a reduction in antioxidant activity. Consequently, it has been hypothesized that maternal supplementation with antioxidants, particularly vitamins C and E, may be beneficial in preventing the occurrence of these disorders. Other important dietary antioxidants include carotenoids, and polyphenols (flavonoids). In general, studies of the effect of providing supplementary vitamin C and E t
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44

O’Neal, M. Angela. What Imaging Test Do I Order? Edited by Angela O’Neal. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190609917.003.0012.

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The case illustrates how to approach imaging in pregnancy. Some basic principles of radiation exposure are reviewed. The effects of radiation are divided into either deterministic, dose-related, or stochastic, where exposure determines the probability of an outcome. Deterministic effects have a threshold below which the effect does not occur. The threshold may be small and may vary from person to person; whereas stochastic effects occur by chance and may occur without a threshold level. Cancer caused by radiation is an example of a stochastic effect. The overall safety of magnetic resonance im
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45

DeSnyder, Sarah M., Simona F. Shaitelman, and Mark V. Schaverien. Lymphedema and Body Image Disturbance. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190655617.003.0010.

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Abstract: Lymphedema is a dreaded side effect of cancer treatments. Studies within the field of psychosocial oncology have shed light on the profound effect of lymphedema secondary to treatment of cancer on quality of life, body image, activities of daily living, and financial stress. Patients who develop lymphedema are at risk for body image disturbances. It is critical for healthcare providers to recognize and treat lymphedema at its earliest stages not only to control lymphedema but to mitigate the detrimental downstream effects of lymphedema including body image disturbance, social anxiety
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46

Lameire, Norbert. Yellow fever, severe acute respiratory syndrome virus, and H1N1 influenza infections. Edited by Vivekanand Jha. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0190_update_001.

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Serious yellow fever infections are associated with acute kidney injury (AKI) on the basis of haemorrhagic shock with acute tubular necrosis, although a direct viral effect on renal tissue has been suggested. A single yellow fever vaccination provides sufficient immunity against the disease, negating the need for booster vaccinations every 10 years; vaccination failures are extremely rare. Severe SARS infections may be complicated by multi-organ dysfunction syndrome including AKI. Hypotension caused by nosocomial infections, gastrointestinal bleeding, or SARS per se, and rhabdomyolysis were as
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47

Swirsky-Sacchetti, Thomas, and Robert L. Rider. Cognitive Interventions: Brain Training and Rehabilitation. Edited by Anthony J. Bazzan and Daniel A. Monti. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190690557.003.0016.

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The research pertaining to two types of cognitive interventions is reviewed. Brain training, which utilizes a variety of computer based approaches, is designed to improve normal performance by developing cognitive skills. Cognitive remediation is designed to improve performance in the face of acquired deficits. Such programs are designed to help patients with existing mild cognitive impairment or dementia. Although not uniform, there is mounting evidence that these interventions have a beneficial effect. However, research also suggests the beneficial effect of such programs is often limited to
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48

Hughes, Thomas. Foundations of clinical practice. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.0001.

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♦ Conscious and unconscious competency♦ Clinical research and the placebo effect♦ Trial design and the randomized controlled trial♦ Critical review of the literature♦ Clinical governance and audit♦ Capacity and consent♦ Principles of teaching and learning.
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49

Smedley, Julia, Finlay Dick, and Steven Sadhra. Haematological disorders. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199651627.003.0015.

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Bone marrow aplasia 324Anaemia 326Methaemoglobinaemia 328Haemolysis 329Haematological malignancies 330•Ionizing radiation: acute (usually accidental) exposure to a dose of ionizing radiation above ~0.2Sv produces marrow hypoplasia/aplasia as a deterministic (dose-related) effect.• nuclear industry• medical radiography and nuclear medicine...
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50

Colebourn, Claire, and Jim Newton. The left ventricle in critical illness. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198757160.003.0002.

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This chapter reviews the structure and physiology of the left ventricle and details assessment methods and their safe usage. It looks in detail at the effects of critical illness on left ventricular function, specifically including the effect of sepsis, ischaemia, and drug toxicity.
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