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Journal articles on the topic 'Efficacies of Ayurvedic Formulatins'
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1
Abhilash, Mullasseril. "Incorporation of Artificial Intelligence to Compute the Drug Efficacies of Ayurvedic Formulations- a Theoretical Approach." J. of Advancement in Medical and Life Sciences 7, no. 3 (2020): 04. https://doi.org/10.5281/zenodo.3753181.
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The Indian System of Medicine especially Ayurveda contributes significantly for the development of global healthcare. It has a very strong conceptual base and has been uninterruptedly practicing not only in India but also in many foreign countries. The introduction of Artificial Intelligence to the field of the Ayurveda to compute the Efficacies of various formulations based on its philosophical bases were successfully carried out. A new term called Drug Efficacy Index Q(VPK) is introduced to the scientific literatures. The Natural Language Processing (NLP) tools based on the Paninian perspective can also be successfully utilized to translate and interpret the terminologies used.
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Mullasseril, Abhilash. "Computation and comparison of the drug efficacy indices [Q(VPK)] of certain ayurvedic foot care formulations." Journal of Ayurvedic and Herbal Medicine 1, no. 3 (2015): 74–76. http://dx.doi.org/10.31254/jahm.2015.1304.
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Aim: The medical science Ayurveda being one of the oldest system of alternative medicines have its own well studied philosophy rooted to Vedic age and in a unique way the great Indian Rshis the very founders of Ayurveda observed the nature and developed many simple but fruitful formulations to cure various ailments for the sake of the entire human society. The present study aims to predict theoretically the efficacies of certain Foot Care Ayurvedic formulations including the modern patented and proprietary medicines by computing their respective Drug Efficacy Indices. Method: The efficacies of certain classical as well as proprietary Ayurvedic Foot care Formulations were theoretically calculated using a simple mathematical formula computed based on traditional and fundamental principles of Vedic Ayurveda. Results: The Drug Efficacy Indices of the selected formulations were numerically computed using an equation based on the dravyaguna vingnaneeya and categorized to corresponding pharmacological groups. Apart from these certain foot care formulations were theoretically designed using the developed computational methods and their corresponding Drug Efficacy Indices were computed and compared. Conclusion: The present study categorized the commonly used Foot care formulations according to their pharmacological activities. The present study also showed the practical application of Computer Aided Drug Designing (CADD) of two foot care formulations based on the classical principles of Ayurveda by effective incorporation of modern concepts like Artificial Intelligence to the most fruitful and simple manner.
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Karnwal, Shivani, C. B. Dhanraj, and N. Sujatha. "A REVIEW ON YOGARAJ RASAYANA – AN AYURVEDIC FORMULATION." International Ayurvedic Medical Journal 11, no. 9 (2023): 2295–301. http://dx.doi.org/10.46607/iamj2011092023.
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Rasayana is one of the panoramic realms of Ayurveda, which comprises specialized use of herbs, herbo-mineral formulations, diet and lifestyle along with behavioral code of conduct to achieve the optimum state of tissues and systems of the body so that there is least effect of external disease causing factors on the In other words, it can be stated that Rasayana is a way to achieve homeostasis and thus retard the process of tissue degeneration leading to prevention of diseases. In healthful condition, Rasayana may be understood as dietary dynamics for rejuvenation of frame and psyche. Among various types of Rasayana classification, Naimittika Rasayana is a disease-oriented therapy. A vast number of Naimittik Rasayana drugs and other poly herbal formulations have proven their efficacies in managing various diseases. One Such drug is Yogaraj Rasayana. It has many pharma-co - therapeutical applications. It is formulated with broad spectrum activity and is indicated in various diseases pertaining to Sarvadhatukshaya. Despite great technological advancement in medical science, the management of immunological infections is still a great challenge. At this juncture, it becomes essential to explore and adopt different Naimittik Rasayana therapies hidden in classical texts of Ayurveda for their proper utilization. Thus, here is an attempt to highlight the immune-modulative and rejuvenating effects of Yogaraj Rasayana in accord-ance with the classical and current literatures.
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Tanushree, Roy, and Gupta Mradu. "EVALUATION OF PERIPHERAL AND CENTRAL ANALGESIC EFFICACIES OF AYURVEDIC NEW FORMULATION FOR AMAVATA DISEASE IN ANIMAL MODEL THROUGH WRITHING TEST AND TAIL -FLICK IMMERSION TEST IN MICEMODEL- AN ANIMAL EXPERIMENTAL STUDY." October 2023 11, no. 10 (2023): 2402–7. http://dx.doi.org/10.46607/iamj0211102023.
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Background: Rheumatoid arthritis (RA) is a chronic inflammatory disorder, it is the most common persistent inflammatory arthritis, occurring throughout the world and in all ethnic groups. This is the most marked in those with severe diseases, with a reduction in expected lifespan by 8-15 years. Around 40% of RA pa-tients are registered disable within 3 years, around 80% are moderately to severely disables within 20 years, and 25% will require a large joint replacement. Functional capacity decreases most rapidly at the beginning of disease and the functional status of patients within their 1st year of RA is often predictive of long-term out-come(1). Aim: In research field RA need more attention for deep research due to, firstly its unbearable symptoms and secondary complication and secondly in modern science there are medicines available for temporary manage-ment purpose but with lot of adverse reaction. RA is a non-curable disease, in Ayurveda, RA can be corelated with Amavata disease (Rheumatoid arthritis). Methodology: In this present study It has been taken up to see the efficacy of new combined Ayurvedic formu-lation i,e combination of Stem of Asthishrinkhala (Cissus quadrangularis L), bulb of Sunthi (Zingiber offici-nale Roscoe) and bulb of Rasona (Allium sativum L) with (1:1:1) ration for better management with less side effects. This research firstly done on animal to evaluate central and peripheral activity of research drug, through Writhing Test and Tail -flick immersion test in Mice model.
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Kiran Shazadi. "Comparative analysis of antibacterial and antioxidant properties of transdermal preparations containing castor oil." Journal of Contemporary Pharmacy 2, no. 2 (2019): 29–36. http://dx.doi.org/10.56770/jcp201806.
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Medicinal plants play vital role in preservation of healthy human life. In these medicinal plants Ricinus communis has great importance that belongs to the family Euphorbiaceae. It is found all over Pakistan. Castor Oil obtained from this plant is highly useful in Homeopathic, Ayurvedic, and Unani system of medicines as a fertilizer, fungicidal, antibacterial, cathartic and purgative. It also used as a labor pain inducer and as an ingredient in many cosmetics products for preventing wrinkles, fight acne, as a moisturizing ingredient, soothing the sunburn and reduce inflammation of skin. Method: Two types of transdermal patches were formulated, one containing combination of castor oil and acetone emulsion A while other formulation emulsion B was contain castor oil, acetone and antioxidants i.e. Vitamin C and E. Both formulations were evaluated by in vitro for antibacterial and antioxidant activities. Results: The outcomes indicated that transdermal patch containing emulsions A have TPC 136, TFC 59.8, reducing power assay 74%, DPPH 75% of inhibition. Transdermal patch containing emulsion B have TPC 150, TFC 77.23, reducing power assay 51%, DPPH 61.90% of inhibition in vitro antibacterial activity showed that castor oil + acetone emulsion containing patches showed 4 µg/ml MIC for E. coli and 2 µg/ml MIC for S. Aureus. For, vivo testing, these transdermal patches was applied on skin wounds of rabbits to study its wound healing activity. Conclusion: It was concluded that transdermal patch containing emulsions B have more efficacies in wound healing then patches A at the end of 20 days.
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Palak*, Dev Prakash Dahiya Chinu Kumari Shalu Bharti. "Formulation And Evaluation Of Polyherbal Gel." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 11–24. https://doi.org/10.5281/zenodo.13625551.
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Ayurveda is one of the traditional Indian mending systems. The gospel of Ayurveda is to help gratuitous suffering and live a long healthy life. Ayurveda involves the use of natural rudiments to exclude the root cause of complaint by restoring balance while creating a healthy life to help imbalances from recreating. Herbal drugs live throughout the world with a long recorded history and have been used in ancient Chinese, Greek, Egyptian and Indian drug for a variety of remedial purposes. The World Health Organization estimates that 80 of the world's population still relies primarily on traditional drugs for health care. The key of India is well known as one of the major centers of biodiversity with about 45,000 factory species. About 15,000 medicinal shops have been recorded in India, in which communities used 7,000 to 7,500 shops to treat colorful conditions. In Ayurveda, single or multiple sauces( polyherbal) are used for treatment. Ayurvedic literature Sarangdhar Samhita' emphasized the conception of polyherbalism to achieve lesser remedial efficacity. The active phytochemical factors of individual shops are inadequate to achieve the asked remedial goods. Combining further sauces in a certain rate will have a better remedial effect and reduce toxin. This review focuses primarily on the significance of polyherbalism and its clinical applicability. crucial words Ayurveda, panchamahabhutas, polyherbal expression .
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R Aithal, Krithika, Sumanth Shenoy H, and Subrahmanya Padyanna. "STANDARD OPERATIVE PROCEDURE FOR FRORMULATION OF MORINDA CIT-RIFOLIA L. GRANULES." International Ayurvedic Medical Journal 04, no. 04 (2020): 2289–92. http://dx.doi.org/10.46607/iamjp040432020.
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The science of life is the basic meaning of Ayurveda. As like any other medical system, success of treatment also depends upon quality of medicine prescribed to the patient. Standardization of Ayurvedic drugs at various levels starting from the selection and collection of raw materials till the final product. It is essential to produce a safe and efficacious formulation for the needy patients. Preparation of granules is one of modified form of Ghana (solid preparation of herbal extract) and Khanda Kalpana (Solid preparation simi-lar to granules). Present study has elaborated formulation of noni granules with analytical studies conduct-ed as mentioned in Ayurvedic Pharmacopia of India. Noni is the common name of the drug Morinda citri-folia L. and is also called as Indian mulberry. It has been used widely as a complementary and alternative therapy owing to its potent antioxidant property and proven health benefits. As every part of noni plant is useful, it is widely used as Antioxidant, Immunostimulant, Immunomodulant, Analgesic, Antiarthritic, An-tipyretic, Antirheumatic, Antitumours, Antispasmodic, Depurative, Diuretic, Antiemetic, Hypotensive, Fungiscide, Laxative, Litholytic, Sedative, Stomachic. The aim of the study is to form noni granules from noni fruit juice by adding adjuvants in order to improve its palatability and shelf life. The prepared gran-ules have shown good palatability and increased shelf life
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N, Wadnerwar. "A Systematic Review on Therapeutic Potential of Shwaskuthara Rasa." Journal of Natural & Ayurvedic Medicine 5, no. 2 (2021): 1–6. http://dx.doi.org/10.23880/jonam-16000313.
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Herbomineral formulations in Ayurved are known for their potency in fewer doses. Shwaskuthara Rasa is one of the herbomineral formulations used very widely in practice. The systematic study was planned to explore the therapeutic potential of the Shwaskuthara Rasa based on Ayurvedic and contemporary assessment parameters from the clinical researches conducted previously with the help of various database. To review the clinical effects of Shwaskuthara Rasa in different diseases based on different assessment parameters, exact dose, duration, Anupana (vehicle) and it’s safety, the articles published in PubMed, Google scholar, Google and ClinicalTrials.gov database and AYUSH online research portal were searched, collected, segregated, analyzed and interpreted. It was observed that Shwaskuthara Rasa is safe and efficacious as a single as well as an adjuvant therapy. But the evidences are scanty to establish the clinical potential of Shwaskuthara Rasa as only seven researches are available with less sample size. Hence, studies are recommended in larger samples in comparison with the standard line of treatment in mild, moderate and severe cases so that it may be useful in emergency condition to treat attacks of Asthma.
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Manish Kumar, Gupta, Dhane Ketaki, Shrivasttva Birendra, Hyam Supriya, and Nagare Sujit. "Methodical Analysis of an Absolute Efficacious Ayurveda Medicine-- Amruthotharam." International Journal of Zoological Investigations 08, special issue (2022): 219–30. http://dx.doi.org/10.33745/ijzi.2022.v08i0s.027.
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Amruthotharam/Amrutottaram Kashayam is one of such preparation which takes care of metabolic disorder through inflammation. The formulation composed of three ingredients-- Tinospora cordifolia, Terminalia chebula and Zingiber officinale. Amrutottaram acts by treating indigestion and neutralization of AMA, thereby helps reduce inflammation and fever by virtue of its immune-modulatory function providing ingredients. The antiinflammatory properties prove to be significant in an array of pathologies like fevers, swelling, systemic inflammation or local inflammations, painful pathologies associated with muscular stiffness, neurogenic pain and thereby useful in any pathology pertaining to any system. The metabolic syndrome is a group of risk factors that together enhance chance of developing cardiovascular disease. The dried drugs were extracted separately by soxhlet extraction process. The present work involved the detailed study of drugs in dried form which can be used in routine analysis of drug. As, the formulation contains Terminalia chebula in major amount, gallic acid was considered as marker compound. The formulation was quantified for the content of gallic acid by HPLC method.
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Dhiman, Dr Esha. "A Clinical Study of Nisha Amalaki Churna in Prameha Purvarupa (Pre-Diabetic State)." International Journal for Research in Applied Science and Engineering Technology 11, no. 10 (2023): 876–80. http://dx.doi.org/10.22214/ijraset.2023.56114.
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The incidence of Prameha is increasing rapidly because of changes in dietetic habits and lifestyle. If the Prameha Purvarupa (Pre-diabetic) clinical features are treated by formulation Nisha-amalaki Churna is recommended in Ayurvedic Classics, Proven efficacious and widely practiced in the management of Prameha (Diabetes). Materials and methods- 30 patients from OPD and IPD of Govt. Ayurvedic College & Hospital, Balangir, fulfilling the Subjective and Objective Parameters were registered for clinical trial. After diagnosis they were under trial with Ayurvedic formulation Nisha-amalaki Churna treated in a dose of 3gm twice daily empty stomach, for a period of 30 days with Ushna Jala. The assessment of subjective and objective parameters were evaluated in 10th, 20th and 30th day from the day of initiation of trial up to 30 days in order to find the efficacy of the trial by statistical paired ‘t’ test
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Suma, Tagadur, Kaliamoorthy Ravikumar, Nagarajan Thamizheseran, and Thirumalai Shantha. "A diagnostic key to identify multiple botanical sources for the Balaa group of Ayurvedic plant drugs." Journal of Non Timber Forest Products 26, no. 4 (2019): 213–24. http://dx.doi.org/10.54207/bsmps2000-2019-oj6u06.
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A conscious effort is certainly needed to provide pure and cleaned forms of plants based drugs for preparation of safe and efficacious herbal formulations. However, such genuine efforts are a rarity. Most often, botanical drugs traded come to users in the form of crude drugs /coarse-finely powdered materials /depilated/ dis-coloured/ mixed forms, which makes the identification of the raw materials, a challenging task with ambiguity. In order to have control on Quality Assurance in herbal industry, an integrated approach of pharmacognosy discipline plays a vital role in authentications and certification of genuine plant materials. To facilitate this process, various tools such as taxonomic evaluation to microscopic studies; gene sequencing to phyto-chemical studies are employed. In this article, an attempt has been made to develop a simple diagnostic key based on analysis of trichome characters for 14 botanical entities, which are recorded to be used as Balaa in various popular Ayurvedic formulations and traditional practices.
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Tikhat, Kirti B., and Ganesh S. Tekale. "PHARMACEUTICAL STUDY OF TRIBHUVANKIRTI RASA: A HERBOMINERAL FORMULATION." International Ayurvedic Medical Journal 9, no. 12 (2021): 2914–19. http://dx.doi.org/10.46607/iamj0109122021.
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Tribhuvankirti means familiar in three lokas i.e. Akash, Patal, Pruthvi. The disease which persists at the time of birth and death is Jwara. Tribhuvankirti Rasa is the most efficacious herbomineral ayurvedic drug widely prescribed by physicians for the treatment of different types of Jwara especially Sannipataj Jwara. It is a Kharaliya Rasayana which contains Hingula, Vatsanabha, Trikatu, Tankan, Pippalimoola and Bhavana of Tulsi Patra Swaras, Ardrak Swaras and Dhattur Patra Swaras. In this paper, pharma- ceutical aspects of Tribhuvankirti Rasa prepared by the reference of Yogaratnakar are discussed i.e. de- tailed pharmaceutical procedures adopted for the preparation of Tribhuvankirti Rasa have been dis- cussed such as Vatsanabha Shodhan, Hingul Shodhan, etc. This study will serve as a guide for those who want to reproduce Tribhuvankirti Rasa in future that provide them with the details on what has to be done at each step of production. Keywords: Tribhuvankirti Rasa, Hingul, Tankan, Borax, herbomineral preparation.
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Dhiman, Esha, Neetu Jha, Pradip Kumar Panda, Utkalini Nayak, and Vinod Chandra Singh. "A CLINICAL STUDY OF SHILAJEET VATI IN PRAMEHA PURVARUPA (PRE-DIABETIC STATE)." International Ayurvedic Medical Journal 9, no. 11 (2021): 2665–70. http://dx.doi.org/10.46607/iamj0409112021.
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Introduction- The incidence of Prameha is increasing rapidly because of changes in dietetic habits and lifestyle. If the Prameha Purvarupa (Pre-diabetic) clinical features are treated by formulation Shilajeet is recommended in Ayurvedic Classics, proven efficacious and widely practised in the management of Prameha (Diabetes). Materi- als and methods- 30 patients from OPD and IPD of Govt. Ayurvedic College & Hospital, Balangir, fulfilling the Subjective and Objective Parameters were registered for the clinical trial. After diagnosis, they were under trial with Ayurvedic formulation Shilajeet Vati treated in a dose of 2 Vati (500mg each) twice daily empty stomach, for a period of 30 days with Ushna Jala. The assessment of subjective and objective parameters was evaluated on the 10th, 20th and 30th day from the day of initiation of trial up to 30 days in order to find the efficacy of the trial by statistical paired ‘t’ test. Observation and results- The average percentage of improvement in subjective parame- ter Prabhuta Mutrata (quantity) 71.43%, Prabhuta Mutrata (frequency) 77.78%, Pipasa (increased thirst) 72.73%, Kshudha (excessive appetite) 72.22%, Kara-pada Daha (burning sensation in hand and feet) 73.81%,Kara-pada Suptata (numbness of hand and feet) 80%, Sweda Pravritti (excessive sweating) 83.33%, Mukha Sho- sha (dry mouth) 79.17%, Mukha Madhurya (sweetness in mouth) 77.78%, Sheeta Priyata (liking for cold things) 80% and Madhura Shukla Mutrata (sweetness in urine) 100% and in objective Parameter fasting plasma glucose 68.89%, postprandial glucose 81.11%, HbA1c 73.33%. It has been observed that the trial drug patients are highly significant (p<0.001) to reduce both Subjective and Objective parameters after 30 days of treatment. Discussion and Conclusion- Prameha is a Kapha Pradhana Tridoshaja Vyadhi in which Meda is a Pradhana Dushya. The drug showed a potent Pramehahar effect which is evident from the reduction in the Subjective Parameter of Prameha and objective parameter of the levels of FBS, PPBS and HbA1c in patients. No side effect was noticed during the clinical study of Shilajeet Vati. Keywords: Prameha, Diabetes, Shilajeet Vati.
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Sahoo, Preetimayee, and Nihar Ranjan Mahanta. "SHWETA CHURNA – ANUBHUTA YOGA IN SKIN FUNGAL INFECTIONS." International Ayurvedic Medical Journal 13, no. 02 (2025): 371–74. https://doi.org/10.46607/iamj1113022025.
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Among the various medicine preparations of Ayurveda mentioned in the classical texts, many medicines have been proven to be efficacious by clinical research. Apart from the classically described medicines, many formulations are used in some specific places and are unknown to all. These are called Anubhuta Yogas. Shweta churna contains Suddha Tankana and Karpura in an 8:1 ratio. This preparation is widely used in Odisha for various fungal infections as a local application. This article is an effort to draw the attention of our new researchers to do clinical studies, research and reviews on the preparation and establish the efficacy of the medicine with evidence
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Balaraman, Gajapathi, V. M. Jerbin Vijay, P. Joanna Gracy, S. Arul Kumar, S. Vishali, and G. Harish. "Exploring the Antibacterial and Antifungal Efficacy of Herbal Plants: An Ayurvedic Research." Journal of Pharmacy and Bioallied Sciences 16, Suppl 5 (2024): S4741—S4745. https://doi.org/10.4103/jpbs.jpbs_884_24.
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ABSTRACT Context: Nature has endowed humanity with a vast repository of remedies that have been use for ages to heal all sorts of ailments. Aim: To evaluate the antibacterial and antifungal efficacy of three herbal plants (Justicia adhatoda, Glycyrrhiza glabra, and Punica granatum), on three microorganisms (Streptococcus mutans, Staphylococcus aureus, and Candida albicans) that are present in the oral stoma. Settings and Design: In vitro microbial study. Methods and Material: Extracts of 0.3 mg/ml, 0.6 mg/ml, 1.25 mg/ml, 2.5 mg/ml, 5.0 mg/ml, and 10.0 mg/ml were prepared from leaves of Justicia adhatoda, barks of Glycyrrhiza glabra, and fruits of Punica granatum, respectively. The antibacterial and antifungal efficacies of the extracts were evaluated by agar well diffusion method and their resultant zone of inhibition. Statistical Analysis Used: One-way ANOVA test and Tukey HSD post-hoc test. Results: The order of antimicrobial efficacy observed in increasing order—Glycyrrhiza glabra < Justicia adhatoda < Punica granatum. Higher the concentration of plant extract, increased the zone of inhibition. Conclusion: The extracts of Justicia adhatoda, Glycyrrhiza glabra, and Punica granatum were found to be effective against oral pathogenic microorganisms.
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Akanksha, Sahil Kumar* Munish Goyal Nasira Abbasi. "Herbal Digestive Powder: A Comprehensive Review on Composition, Mechanisms, and Clinical Efficacy." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 363–69. https://doi.org/10.5281/zenodo.15334174.
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Digestive health plays a critical role in maintaining overall physiological and metabolic equilibrium. Herbal digestive powders, based on centuries-old traditional medical systems such as Ayurveda, Unani, and traditional Chinese medicine, have emerged as efficacious, safe, and economically viable alternatives to conventional therapies. These formulations are composed of multiple medicinal plants possessing diverse pharmacological activities, including stimulation of digestive enzymes, modulation of gut motility, prebiotic actions, and anti-inflammatory properties. This comprehensive review discusses the phytochemical profiles, mechanisms of action, scientific validation, clinical efficacy, regulatory status, and future directions of herbal digestive powders. Emphasis is placed on the integration of traditional knowledge with contemporary scientific methodologies to establish rational and evidence-based utilisation.
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Manas Ranjan Sahoo, Marakanam Srinivasan Umashankar, Ramesh Raghava varrier, and Paul Pandian. "Development and evaluation of polyherbal based medicated candy from Ayurveda herbs reported for cough and cold and Evaluation of their anti-viral and anti-bacterial properties." International Journal of Research in Pharmaceutical Sciences 12, no. 1 (2021): 280–91. http://dx.doi.org/10.26452/ijrps.v12i1.3990.
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Emergence and spread of new viral and bacterial originated infectious diseases along with mutated new strains posing enormous global challenges. Respiratory infection is one of the major concerns in the current and past situation. With the lack of a safe and effective vaccine and small molecules drugs for effective treatments there is a need of efficacious herbal medicine to tackle infectious diseases. The herbal treatments mentioned in the Ayurveda can be excellent source for an effective treatment. In the present study a hard- boiled candy formulation was from promising herbs recommended herbs from Ayurveda for respiratory health and immunmodulatory actions. The herbs selected were Ocimum sanctum-OS (leafs), Terminalia chebula-TC (fruit), Glycyrrhiza glabra-GG (roots), Curcuma longa-CL (rhizomes), Zingiber officinale-ZO (rhizomes), Piper longum-PL (fruits). The herbs were evaluated for antiviral and antibacterial activity. The results indicated that most of the extracts exhibited antimicrobial activity against pathogens B. subtilis, S.aureus, S.pyogens and S.pneumoniae and showed significant antiviral activity against DENV virus in vitro. The formulated hard-boiled candy was found to be having satisfactory quality parameters of hardness, friability, and dissolving time. The HPTLC profile was developed for the candy formulation as an effective quality control tool. This study indicates that the hard-boiled candy (HBC) could be an ideal solid oral dosage form for herbal drug delivery at local region of oropharyngeal region.
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Sharma, Narinder, Aman Gupta, and Dheeraj Khajuria. "A Birds Eye View on Different Ayurvedic Treatment Modalities in Cerebral Palsy in Children." International Research Journal of Ayurveda & Yoga 7, no. 6 (2024): 27–33. http://dx.doi.org/10.48165/irjay.2024.70605.
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Introduction: Cerebral palsy (CP) is a permanent, non-progressive, and occasionally evolving disorder of tone, movement, or posture caused by a change to the developing brain, which may be due to birth asphyxia, trauma, infection, or prematurity in antenatal, perinatal, or post-natal periods. Material and Methods: A systematic review of the literature available was carried out on PubMed, Ayush Research Portal, Dhara, and Scopus regarding Ayurvedic intervention in the management of CP. Results: The treatment program for a child with spasticity may include Ayurvedic drugs, allied health therapy, and exercise. Ayurveda recommends multiple treatment options for CP. Out of these treatment options herbal drugs, Panchakarma therapies, etc. are most commended for this disease. Discussion: The present paper reviewed various clinical studies to ascertain the efficacies of these modalities and found that Ayurveda can efficiently manage CP along with its associated condition by improving movement, reducing spasticity, and strengthening the muscles. Conclusion: The current review provides motivating evidence for the usage of herbal treatment in CP and further research utilizes robust available methodology. Cerebral palsy (CP) is a motor function disorder caused by a defect in the developing brain, which may be due to birth asphyxia, trauma, infection, or prematurity in antenatal, perinatal, or postnatal periods. In developing nations like India, the incidence of CP is approximately 3/1,000 live births. This has not altered recently despite better antenatal care and public health.[1] Although CP begins in childhood, it impacts the individual’s whole life course as well as the health-care system. Identifying appropriate interventions to alleviate disability throughout the life of a person with CP is urgent.[2] The male gender was classified as a risk factor for CP. Epilepsy has been shown to be the most commonly associated comorbidity.[3] CP is predominantly a mobility issue, but many children who have it also have additional
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Jamal Basha D, Kumar P R, and Ranganayakulu D. "Primordial science and pioneering approaches of guggul for chronic ailments – A modernized review." International Journal of Pharmaceutical Research and Life Sciences 7, no. 2 (2020): 14–20. http://dx.doi.org/10.26452/ijprls.v7i2.1193.
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An oleo gum resin guggulu is a product which obtained as a result of gummosis from the bark of Commiphora wightii (Arnott) Bhandari [syn. Commiphoramukul (Hook. Ex Stocks) Family, Burseraceae]. It has been known for its immense applicability in the Ayurveda since time immemorial for the treatment of variety of disorders such as inflammation, gout, rheumatism, impotence, leprosy, obesity, and disorders of lipids metabolism. It is a mixture of phytoconstituents like terpenoids, steroids, flavonoids, guggultetrols, lignans, sugars, and amino acids. This review is an effort to compile all the information available on all of its chemical constituents which are responsible for its therapeutic potential, limitation of guggul extracts and the necessity of novel principles for gum guggul. Nowadays, Guggul is available as the marketed formulation for curing numerous clinical conditions and is accessible in combination with various other ingredients. Though conventional dosage form shows the dominance as patient compliance and easy availability, yet it has found to pose the problems like dose fluctuation, peak-valley effect, non-adjustment of the administered drug, invasiveness etc. Guggul lacks its desired effect due to its low bioavailability and water solubility. This makes it a partial or a deficient therapy for remedy of many signs and symptoms. Novel drug delivery system (NDDS), a new approach and has excluded many of drawbacks exhibited by conventional dosage forms. Some of the novel dosage forms of guggul has been formed like nanoparticles, nanovesicles, gugglusomes and proniosomal gel. But still, the novel formulations for guggul has its less outspread in the market. Guggul can be executed as a profitable drug using NDDS. There is a need to highlight the unidentified and unexplained facts about guggul so as to make it more efficacious and effective in terms of bioavailability and aqueous insolubility.
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Sharma, Rohit, and PK Prajapati. "Screening of Antimicrobial activity of Guduchi Ghana (dried aqueous extract of Tinospora cordifolia (Willd.) Miers)." Journal of Ayurvedic and Herbal Medicine 2, no. 6 (2016): 209–12. http://dx.doi.org/10.31254/jahm.2016.2604.
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Guduchi (Tinospora cordifolia (Willd.) Miers) is one of the most versatile rejuvenating herbs, possessing numerous therapeutic attributes. Recent reports investigated and ascertained its role as a potent antimicrobial herb. No published reports on antimicrobial profile of its dosage form- Guduchi Ghana are available till date. Present study was therefore attempted to evaluate comparative antimicrobial efficacies of Guduchi Ghana prepared by two different methods – (i) classical Ayurvedic method and (ii) modified method. Recommended microbial strain like; Salmonella typhi, Escherichia coli, P. aeruginosa and Staphylococcus aureus were used in this study for the same purpose. Both samples showed significant antibacterial activity and possess great potential against microorganisms, where Guduchi Ghana prepared by classical method showed better results. Physicochemical analysis showed insignificant difference between samples. Phytochemical analysis for various functional groups revealed the presence of glycosides, alkaloids, tannins, phenols, starch and sterols in both samples, which might be accountable for their antimicrobial potential. No microbial load was detected within both samples. The results also validate the traditional uses of Guduchi in various skin ailments. Present study may prove a torch bearer for future studies to understand its biological activities.
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Sahoo, Preetimayee, and Nihar Ranjan Mahanta. "A Critical Analysis on A Multipotent Drug Chandraprabha Vati - Review Article." International Research Journal of Ayurveda & Yoga 05, no. 01 (2022): 105–17. http://dx.doi.org/10.47223/irjay.2022.5116.
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ChandraprabhaVati is a very commonly used herbo-mineral preparation in dayto-day practice being efficient in various disorders mostly genitor-urinary ones. Chandraprabha Vati is available in various ayurvedic texts with different preparations and different ingredients. The preparation, described by Sarangdhar Samhita and accepted by AFI, is being taken for a critical review of its properties, actions and its clinical efficacies in different diseases. It is made up of 37 ingredients with Shilajit and Guggulu present in maximum quantity 32 parts each. It is katu (73.38%) tikta (69.78%) in rasa, laghu (76.98%) ruksha (74.10%) in guna, ushna virya (70.50%), katu vipaka (69.06%) and tridosha shamak predominantly Vatakapha shamak (91.37% and 84.89% respectively). This preparation is indicated in Prameha, Mutravahasrotaja vyadhi, Anaha, Shoola, Shwasa, Kasa, Shukradosha, Pandu, Kamala, GudagataVyadhi, Netraroga, Dantaroga, Kushtha and various other diseases as mentioned in different texts. Clinical studies have also proved its efficacy in various diseases. It is antidiabetic, anti-inflammatory, anti-tumour, renal protective, hepato-protective, effective in jaundice and genitor-urinary diseases like UTI, dysmenorrhoea, PCOD, female infertility, etc. and many diseases are still left to be explored. Chandraprabha Vati is a multifaced drug and can be used in a variety of ailments successfully.
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Mamgain, Neha, Akansha Anupam, and Shikha Pandey. "SHATAVARI GHRITA CONTRIBUTION TO FEMALE HEALTH: A REVIEW." International Journal of Research in Ayurveda and Pharmacy 15, no. 3 (2024): 171–74. http://dx.doi.org/10.7897/2277-4343.15393.
Full textAbstract:
Every phase of a woman’s life is marked with a range of health issues right from menarche to her postmenopausal years. The medical science has come up with solution for all of the problems but there is no denial to the accompanying side effects and adverse reactions. This is the reason the world is looking towards Ayurveda for a natural, cost effective, safe and efficacious solution. Shatavari is a wonderful drug having innumerable benefits for females. It is beneficial to maintain normal reproductive health. It is used either alone in extract form or most commonly is an important ingredient of many compound formulations. Shatavari Ghrita comes under Sneha kalpana which is prepared by using 1part of Kalka dravya (drugs in paste form), 4 parts of Sneha dravya (Sneha may be Ghrita/ Taila/ Vasa/ Majja. Out of these, Ghrita is the best due to Sanskaranuvartan property. It effectively assimilates the properties of other drugs without losing its own) and 16 parts of Drava dravya (drugs in decoction form). Ghrita can be used in the form of Pravicharana (preparation) as Pana, Abhyanga, Nasya, Basti and Uttarbasti. Shatavari being a Rasayana, this Ghrita is useful in many other gynecological disorders like Oligomenorrhea, Amenorrhea, Infertility, Post menopausal symptoms etc.
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R, Bhagat. "Potential Antiviral Herbal Therapeutics for Viral Infections." Journal of Natural & Ayurvedic Medicine 7, no. 2 (2023): 1–7. http://dx.doi.org/10.23880/jonam-16000404.
Full textAbstract:
Background Ayurved, an ancient system of medicine with rich heritage and antiquity, is well known since Vedic period. Viral infections are responsible for many illnesses, and recent outbreaks have raised public health concerns. Viral infections are being managed therapeutically through available antiviral regimens with unsatisfactory clinical outcomes. The refractory viral infections immune to available antiviral drugs are alarming threats and a significant health concern. For hepatitis, the interferon and vaccine therapies solely aren't ultimate solutions thanks to recurrence of hepatitis C virus. Owing to the growing incidences of viral infections and particularly of resistant viral strains, the available therapeutic modalities got to be improved, complemented with the invention of novel antiviral agents to combat refractory viral infections. It is widely accepted that medicinal plant heritage is nature gifted, precious, and fueled with the valuable resources for treatment of metabolic and infectious disorders. The aims of this review are to assemble the facts and to conclude the therapeutic potential of medicinal plants within the eradication and management of various viral diseases such as influenza, human immunodeficiency virus (HIV), herpes simplex virus (HSV), hepatitis, and coxsackievirus infections, which have been proven in diverse clinical studies. The scientific literature mainly focusing on plant extracts and herbal products with therapeutic efficacies against experimental models of influenza, HIV, HSV, hepatitis, and coxsackievirus were included in the study. Pure compounds possessing antiviral activity were excluded, and plants possessing activity against viruses other than viruses in inclusion criteria were excluded. Hundreds of plant extracts with antiviral effect were recognized. On the basis of the work of several independent research groups, the therapeutic potential of medicinal plants against listed common viral diseases in the region has been proclaimed. In this context, the herbal formulations as alternative medicine may contribute to the eradication of complicated viral infection significantly. The current review consolidates the data of the various medicinal plants, holding promising specific antiviral activities scientifically proven through studies on experimental animal models. Consequently, the original research addressing the development of novel nutraceuticals based on listed medicinal plants is highly recommended for the management of viral disorders
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Mullasserill, Abhilash. "Computation and Comparison of The Drug Efficacy Indices [Q(VPK)] of certain Ayurvedic Hair Care Formulations." International Journal of Ayurvedic Medicine 6, no. 3 (2015). http://dx.doi.org/10.47552/ijam.v6i3.652.
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      The Ayurveda being one of the oldest systems of alternative medicines have its roots in Rgveda the oldest monument of human civilization. Indian Rishis kept this system as their eyeball and developed many useful formulations to the entire human society. The present study aims to predict the efficacies of certain Hair Care Ayurvedic formulations including the modern patented and proprietary medicines by computing their respective Drug Efficacy Indices. The Drug Efficacy Index is a new concept that could be considered as the direct measure of efficacy of various Ayurvedic formulations.Â
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Manikandaselvi, S., A. Sudha, V. Vadivel, C. David Raj, C. Prabu, and P. Brindha. "BIOCHEMICAL EVALUATION AND SCIENTIFIC VALIDATION STUDIES OF AN HERBAL NUTRACEUTICAL (IN PRESS)." Resource-Efficient Technologies, no. 1 (May 14, 2021). http://dx.doi.org/10.18799/24056537/2021/1/285.
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The search for pioneering nutraceuticals from plants is genuine and crucial. Based on the literature review as per Ayurvedic texts, four common plants Capparis spinosa L. (flower buds), Caesalpinia bonducella L.(seeds), Luffa acutangula L.(fruits) and Cassia occidentalis L. (aerial parts) were selected to develop nutraceuticals and were standardized. Based on the nutraceutical and pharmacological efficacies of the individual plant drugs selected, three different herbal nutraceutical formulations were prepared. Nutraceuticals before and after lyophilization were subjected to standardization studies. Nutraceutical formulation 3 developed was found to be best due to its high nutraceutical values when compared to others. Results depicted that up to the dose level of 2000 mg/kg.bw (acute oral toxicity), 1000 mg/kg.bw (sub-acute oral toxicity), it doesn’t produced any lethality in the experimental animals. To conclude that the selected herbal formulation developed from selected plant ingredients was found to possess distinct nutraceutical values. The present work contributes for the development of human healthcare through nutraceutical product with remarkable medicinal properties in herbal way.
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Athira. S, Arun Pratap, and Lekshmi. R. "The Role of Go Ghrita in Epilepsy - A Review." AYUSHDHARA, June 30, 2023, 45–50. http://dx.doi.org/10.47070/ayushdhara.v10i3.1249.
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Epilepsy, a chronic neurological condition, can potentially allow up to 70% of individuals to live seizure-free with appropriate diagnosis and treatment, but it also carries a threefold higher risk of premature death compared to the general population, underscoring its seriousness. Epilepsy is a chronic neurological condition characterized by recurrent seizures and disturbances in consciousness. It can be correlated with the Ayurvedic concept of Apasmara, which involves occasional unconsciousness accompanied by unpleasant symptoms such as vomiting froth and abnormal body postures. Ayurveda recognizes Ghrita (ghee), particularly Go Ghrita derived from cow's milk, as a versatile food and medicinal substance with therapeutic effects. Go Ghrita is highly regarded for its ability to balance Vata and Pitta Doshas and its lipophilic nature, allowing it to penetrate the blood-brain barrier for targeted delivery and increased bio-availability. Go Ghrita's Rasayana property suggests that long-term use may help reduce the recurrence of epilepsy. When medications are processed with Ghrita, it enhances their medicinal properties, making formulations utilizing Go Ghrita potentially more advantageous and efficacious for treating epilepsy.
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Dattatraya Ovar, Dayanand, Ujwala Murlidhar Katole, Ganesh Sakharam Deshmukh, and Monish Maruti Shinde. "Classical View on Bhasma as Chief Formulation of Rasashastra: An Ayurveda Review." Himalayan Journal of Health Sciences, August 30, 2021, 14–17. http://dx.doi.org/10.22270/hjhs.v6i3.103.
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Minerals and metals based drugs possess important therapeutic potential and preparation of such medicines described in Rasashastra which deals with minerals and metals based formulations. The processing techniques related to the preparation of these medicines are very specific to make these drugs nontoxic and efficacious. Shodhana means purification and Marana means incineration/calcinations are main procedures associated with the preparation of Rasa- Aushdhis. Bhasmas are important preparation of this category which is considered as herbo-metallic preparation and description of Bhasma Kalpana is found in Ayurveda Samhitas during Arsha Sampradaya. These herbo-mineral/metallic formulations (Bhasma) mainly prepared by various steps of purification, grinding, mixing, heating, incineration and size reduction, etc. These drugs possess advantages of palatability, low dosing frequency, high potency, good bioavailability, optimum absorption and wide range of therapeutic spectrum. Bhasma not only used for therapeutic purpose but also advised for promoting general health and rejuvenating effects. Makshika bhasma, Swarna bhasma, Abhrak bhasma, Louha bhasma and Tamra bhasma, etc. are commonly used Bhasma preparation indicated for many pathological conditions including skin diseases, digestive ailments, sexual disorders, asthma and infections, etc.
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Bhokardankar, Prashant Sakharam. "An over view of medicinal uses of Ayurvedic drug Pippali (piper longum)." National Journal of Research in Ayurved Science 7, no. 4 (2019). http://dx.doi.org/10.52482/ayurlog.v7i4.391.
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Background: Pippali, Piper longum (P.longum) usually called pippali which is a member of the Piperaceae family, is frequently used medicinal herb in Ayurved, Unani & Siddha system of medicine. In traditional medicine world it is being used to treat most of the systemic disorders. This systematic review was conducted with an objective to search, explore & compile the phytochemical constituents & their efficacies both in modern and traditional part to understand as a potential therapeutic agent. Material & method: Published details scientific literature on P. Longum by various research scholars, organizations & Pharmacopeias were reviewed. The review criterion was restricted to bio-efficacy and phyto-pharmacological activities of longum. Results and Conclusions: This review shows various experimental studies conducted on Bio-active compounds isolated from P. longum has prospective uses as anticancer, antilipidemic, antifungal and radioprotective.
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Sonia, Yadav1 Munish Sharma1 Shilpa1 Munish Sharma2*. "Exploring the Phytochemical composition and Pharmacological efficacies of Viola odorata: A Comprehensive Review." July 29, 2023. https://doi.org/10.5281/zenodo.8195140.
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<em>V. odorata</em> Linn., commonly referred to as "sweet violet," is a plant belonging to the violaceae family and has been utilized for its medicinal properties in Ayurvedic and Unani systems of medicine since ancient times. It is indigenous to Europe and Asia. In India, it is commonly known as Banafsa, Banafsha, or Banaksa with multitude of medicinal applications. <em>V. odorata</em> is involved in many traditional practices for the treatment of various ailments such as fever, cough, the common cold, headache, sleeplessness, epilepsy, constipation, heart palpitations, difficult or painful urination, breathing difficulties, and skin issues. All parts of the sweet violet plant have medicinal value and possess various biological properties, including sedative, diuretic, laxative, anti-asthmatic, anti-dyslipidemic, antihypertensive, antidiabetic,
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S., Jyothi, Ravindra Angadi, and Vikram S. "Comparitive clinical study on the effect of Mahatriphaladi Ghrita Tarpana and Jeevantyadi Ghrita Tarpana in Parathama Patalagata Timira w.r.t. Keratoconus." Journal of Ayurveda and Integrated Medical Sciences (JAIMS) 4, no. 06 (2019). http://dx.doi.org/10.21760/jaims.4.6.8.
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Keratonus is one of the important causes of progressive myopia and its incidence is 1 in 500 worldwide. Keratoconus is a degenerative disorder of the eye in which structural changes within the cornea cause it to thin and change to a more conical shape than the more normal gradual curve. Keratoconus typically starts at puberty as a progressive myopia causing substantial distortion of vision and marked astigmatism rapidly. This results in significant visual impairment leading to problems in doing routine works like driving and reading. Only temporary measures like Contact lenses and Surgery are available. In Ayurvedic terms, it can be correlated with Prathama Patalagata Timira. As Tarpana is considered to be supreme among all the Kriyakalpas in treating timira, it has been selected for the study. Giving due importance to the doshas and the site of pathology involved, Jeevantyadi Ghrita and Mahatriphaladi Ghrita are selected. Hence a clinical study has been done to compare the efficacies of Mahatriphaladi ghrita tarpana and Jeevantyadi Ghrita tarpana in Keratoconus.
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Nitin, Biswas, Jajoo Suhas, Jaiswal Reena, and S. R. Kapse. "Comparative Evaluation of the Efficacy of Hydrocortisone Suppository and Durvadi gudavarti in Raktarsha: A Management Protocol." Journal of Pharmaceutical Research International, December 21, 2021, 12–18. http://dx.doi.org/10.9734/jpri/2021/v33i60b34579.
Full textAbstract:
The most common diagnosis for any anorectal complaint particularly of rectal bleeding in adults is haemorrhoidal disease. Regardless of grading conservative treatment is used primarily in symptomatic haemorrhoids. In Ayurveda, Sthanik Chikitsa (Local application) in the management of Arsha (Hemorrhoids) includes pralepa/pratisaran (Paste application). Instead of applying the lepa in the clinics by the clinician/proctologist, those formulations could be developed into Gudavarti (traditional suppository) & used in the management of Raktarsha (bleeding piles) for better compliance. Hence, development of ‘Durvadi Gudavarti’ using the indigenous medicinal herbs mentioned in Charaka Sanhita (Classical Ayurveda text) for pratisaran/pralepa in Raktarsha & its efficacy will be evaluated.
 Objectives: To study & compare the efficacy in patient treated with standard- Hydrocortisone suppository group & interventional- Durvadi Gudavarti group in the management of Raktarsha (Bleeding piles).
 Methodology: 130 patients of 2nd grade hemorrhoids will be selected and will be allocated into two equal groups by computer randomization. Experimental group will be treated with Durvadi Gudavarti & control group with Hydrocortisone based suppository for 2 weeks. Following Symptoms- PR Bleeding, Anal Pain, Prolapse of Pile mass/Lump, Anal pruritus, Mucous discharge & Constipation will be assessed subjectively and Size/ (Volume in cubic millimeter) of pile mass will be the objective parameter for study. Clinical evaluation will be done at Baseline and 3rd, 5th, 10th, 15th day after treatment onset. Proportion of patients that would respond clinically on 10th day will be the main end point, determined via disappearance of the clinical symptoms & more than or equal to 50 % reduction in the initial size of pile mass/lump. Time to response & need for any oral/ parenteral medication for pain, bleeding and constipation would be the secondary variables. Side effects (type, duration & severity) will be registered carefully.
 Expected Results: Durvadi Gudavarti contains indigenous herbs having anti-inflammatory, analgesic, haemostatic, wound healing, astringent, & laxative properties. Hence, it is expected to be as efficacious as Hydrocortisone suppository with lesser side effect in the management of Raktarsha. Results will be assessed on the basis of clinical assessment criteria using proper statistical values and tools. Changes will be observed in objective outcomes.
 Conclusion: Durvadi Gudavarti will be efficacious in the management of Raktarsha.
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SINGH, ANITA, VANDANA SINGH, and DINESH KUMAR B. "ANTI-INFLAMMATORY PROPERTIES OF UNEXPLORED PLANTS – CUSCUTA REFLEXA AND COCCULUS HIRSUTUS – AN EXPERIMENTAL STUDY." Asian Journal of Pharmaceutical and Clinical Research, May 10, 2021, 24–26. http://dx.doi.org/10.22159/ajpcr.2021.v14i7.41735.
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Objective: The study aimed to document the rarely explored plants, namely, Cuscuta reflexa (CRA) and Cocculus hirsutus (CHP) used by the ethnic people of a specific region. The anti-inflammatory (AI) property of kwath of CRA (KCRA), kwath of CHP (KCHP), and their blend (kwath blend [KB]) was also assessed.
 Methods: The KCRA and KCHP were prepared following standard Ayurvedic procedures. The AI property was determined by carrageenan-induced paw edema at doses; 250, 125, and 62.5 mg/kg. The KB (500 mg/kg) was prepared using equal parts of KCRA and KCHP in view of the potential AI property as compared to the individual plants. Ibuprofen (100 mg/kg) was used as the standard AI drug standard drug (SD).
 Results: The carrageenan-induced paw inflammation was highest and doubled at 3 h. The oral administration of SD (100 mg/kg) produced a high reduction of edema (78.47%) at 3 h. Both KCRA and KCHP had reduced edema and were equally potent (EC50; 139.8 and 147.3 mg/kg, respectively) at the early phase. However, the efficacy of KCRA was greater than KCHP at the second phase of inflammation (EC50=313.6 and 2760 mg/kg, respectively). KCRA was efficacious and potent as an AI agent. Unlike SD, KB had effectively inhibited paw edema from the 6th h onward. The AI activity of KB was superior compared to individual plant groups.
 Conclusions: The study demonstrated that the traditional formulation – kwath of rarely explored plants, namely, CRA, CHP, and KB has AI property and can be explored to develop them as AI agents.
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S., Ramesh Kannan, Sivraman V., Vanitha R. Muralikumar, et al. "A Randomized Open Label Parallel Group Clinical Study to Evaluate the Efficacy and Safety of Clevira in Fever of Viral Origin." International Journal of Innovative Research in Medical Science 4, no. 09 (2019). http://dx.doi.org/10.23958/ijirms/vol04-i09/757.
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Objective: To evaluate the efficacy and safety of Clevira, an ayurvedic formulation in fever of viral origin. Methods: This was a prospective, randomised, multicentre, open label, parallel group interventional clinical end point study. Patients attending general outpatient department, were screened for viral fever including Dengue by using the haematological, Biochemical and microbiological anti body assay for Dengue and NS1 (Non-structural protein) antigen testing. Forty eight patients who satisfied the selection criteria were enrolled in the study. Participants were randomized into 4 groups with 12 patients in each group. Patients were given standard treatment. In addition, Tab. Clevira of Apex laboratories Pvt. Ltd., was administered to test groups. Results: There is highly significant improvement (P<0.001) in the subjects Temperature, fever score, arthralgia score, Myalgia score, Headache and loss of appetite, suggesting a good Analgesic and anti pyretic activity of Clevira. There is a significant improvement in platelet count in the Clevira treated group (P<0.01) when compared to the control group, proving its efficacy in treating thrombocytopenia. The improvement (P<0.01) in the WBC count in the Clevira treated group depicts the anti viral property of Clevira. The overall quality of life was better in Clevira treated group compared to the control group. There were no serious adverse events reported. Conclusion: Clevira is safe and efficacious in reversing thrombocytopenia and thus normalizing the platelet counts and relieving the clinical signs and symptoms (fever, myalgia, arthralgia, headache) of Viral fever associated with thrombocytopenia and other cases of viral fever without thrombocytopenia. Clevira is having good anti-viral, antipyretic, analgesic and immunomodulatory property. Hence, Clevira should be used as an add on drug in patients with viral fever with or without thrombocytopenia for a rapid recovery without any adverse effects.
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Wadnerwar, Nilima. "Preclinical Evaluation of Antidotal Property of Mritasanjeevana agada in Poisoning- A Study Protocol." Journal of Pharmaceutical Research International, July 28, 2021, 271–80. http://dx.doi.org/10.9734/jpri/2021/v33i38b32123.
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Background: As the poisoning is becoming a threat to rural India, it is necessary to increase the survival time to avail the primary treatment. For the treatment of poisoning, Agada is described in Ayurveda as an antidote. Agada is a polyherbal or herbomineral formulation constituted with combination antitoxic drugs along with some antioxidant, immunomodulator or hepatoprotective drugs. But they need to be revalidated for their efficacy and safety on the basis of contemporary assessment parameters
 Aim: Evaluation of antidotal property of Mritasanjivana Agada in poisoning.
 Objectives:
 
 To increase the survival time after the administration of Mritasanjivana Agada in snake venom and aluminium phosphide poisoning in albino mice.
 To compare the efficacy of Mritasanjivana Agada and Anti-snake venom as an antidote.
 To standardize the Mritasanjivana Agada.
 
 Methodology: Mritasanjeevana Agada will be prepared and standardized. Cobra venom poisoning and aluminium phosphide poisoning have been selected as the representative for the animate poison and artificial/ synthetic poison. After inducing poisoning in mice, one group will receive its standard antidote and other will receive standard antidote with Mritasanjivana Agada. The third group will receive only Mritasanjivana Agada without its standard antidote. All the groups will be assessed on the basis of hematology, biochemistry, Superoxide dismutase (SOD) level, Malondialdehyde (MDA) level and histopathology in case of death of the animals.
 Results: Mritasanjeevana agada is expected to increase the survival time in the treatment of snake venom and aluminium phosphide poisoning in albino mice.
 Conclusion: Mritasanjeevana agada may be as efficacious as Anti-snake venom as an antidote.