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Journal articles on the topic "EHGM 350"
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Mushtaq, Ahlam, Mubashir Hussain Masoodi, Adil Farooq Wali, and Bashir Ahmad Ganai. "MULTIPLE TREATMENT OF EREMURUS HIMALAICUS EXTRACTS AMELIORATES CARBON TETRACHLORIDE INDUCED LIVER INJURY IN RATS." International Journal of Pharmacy and Pharmaceutical Sciences 8, no. 9 (2016): 24. http://dx.doi.org/10.22159//ijpps.2016.v8i9.11237.
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<p><strong>Objective: </strong><em>Eremurus himalaicus </em>Baker<em>, </em>an edible herb of North Western Himalayas, has not been scientifically assessed for hepatoprotective potential. The ethyl acetate extract (EHE), methanolic extract (EHM) and aqueous extract (EHA) of <em>Eremurus himalaicus </em>were therefore evaluated for potential hepatoprotective activity in Wistar strain albino rats.</p><p><strong>Methods: </strong>Carbon tetrachloride (1.5 ml/kg) was employed as hepatotoxin and was given on Day 1 of the experiment. The extracts at a dose of 300 mg/kg bw (EHE, EHM and EHA) and the standard at a dose of 10 mg/kg bw (Liv 52) were given for following 7 d and the biochemical parameters (SGOT, SGPT, ALP, TP, bilirubin and UA) were estimated in order to assess the liver function. Moreover, the liver tissue samples were examined for histopathological changes.</p><p><strong>Results: </strong>The results for serum biochemical analysis in rats showed a rise in SGOT, SGPT, ALP and bilirubin levels and a decrease in TP and UA levels upon giving hepatotoxin. The administration of the extracts and standard drug, for a period of 7 d, showed a significant decrease in SGOT, SGPT, ALP and bilirubin levels and an increase in TP and UA levels for EHM when compared to the toxic group. These results correlated well with the histopathological findings of liver for normal, toxic and extract treated groups. The EHM treatment decreased the extent of fat deposition and necrosis caused by CCl<sub>4</sub>. The results were almost similar to the standard drug Liv 52.</p><p><strong>Conclusion: </strong>Collectively; the results indicate that EHM exhibits significant hepatoprotective activity against CCl<sub>4 </sub>induced hepatotoxicity.</p>
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Tymoyrimoghadam, Leili, Hossein Momeninejad, Parisa Baratpour, et al. "Advanced oxidation of formaldehyde in the aqueous solutions using UVC/S2 O8 2- process: Degradation and mineralization." Environmental Health Engineering and Management 6, no. 2 (2019): 97–104. http://dx.doi.org/10.15171/ehem.2019.11.
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Background: As a human carcinogen, formaldehyde is a toxic chemical imposing adverse effects on public health and environment. Due to its high reactivity, colorless nature, sustainability, purity in commercial forms, and low prices, the production and consumption of this compound has expanded vastly in industries. Methods: In this study, a UVC photoreactor with a total volume of 120 mL was used and operated in a rotary mode. To determine the residual concentration, high-performance liquid chromatography (HPLC) device was applied whose detector was set at a wavelength of 355 nm and equipped with C18 column (with dimensions of 25 × 4.6 mm i.d, and particle size of 5 µm). Total organic carbon (TOC) was determined using a TOC analyzer. Results: The optimal condition in this study was obtained at pH=3 and formaldehyde concentration of 350 mg, so that the removal of formaldehyde and TOC was 98.2% and 95.1%, respectively, after 35 minutes reaction time. The formaldehyde removal efficiency was assessed in the presence of methanol (MeOH), tert-butyl alcohol (TBA), and salicylic acid (SA) scavengers, and it was indicated that SO4 •- radicals were the most effective factors in formaldehyde destruction. By increasing the concentrations of MeOH, TBA, and SA to 2.5 g/L, the degradation efficiency of formaldehyde dropped from 98.02% to 69.78%, 64.68%, and 45.14%, respectively, at 35 minutes reaction time. The removal of formaldehyde in the presence of nitrate was significantly reduced and it had a significant effect on the removal of formaldehyde. Conclusion: In this study, the removal of formaldehyde was investigated in the presence of various anions including bicarbonate, carbonate, chloride, sulfate, and nitrate. According to the results, the UVC/S2 O8 2- process is a convenient and cost-effective method for the removal of formaldehyde.
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Chavoshan, Soheila, Maryam Khodadadi, Negin Nasseh, Ayat Hossein Panahi, and Aliyeh Hosseinnejad. "Investigating the efficiency of single-walled and multi-walled carbon nanotubes in removal of penicillin G from aqueous solutions." Environmental Health Engineering and Management 5, no. 4 (2018): 187–96. http://dx.doi.org/10.15171/ehem.2018.26.
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Background: Drugs, especially antibiotics, are one of the serious problems of modern life and the main pollution sources of the environment, especially in the last decade, which are harmful to human health and environment. The aim of this study was to investigate the removal of penicillin G from aqueous solutions using single-walled and multi-walled carbon nanotubes. Methods: In this study, the effect of different parameters including pH (3, 5, 7, 9, and 11), initial concentration of pollutant (50, 100, 150, and 200 mg/l), absorbent dose (0.25, 0.5, 0.75, and 1 g/L), mixing speed (0, 100, 200, and 300 rpm), and temperature (10, 15, 25, 35, 45°C) were investigated. The Langmuir, Freundlich, Temkin, BET, Dubinin-Radushkevich isotherms and adsorption kinetics of the first- and second-order equations were determined. Results: The results showed that the efficiency of single-walled and multi-walled carbon nanotubes in the removal of penicillin G was 68.25% and 56.37%, respectively, and adsorption capacity of the nanotubes was 141 mg/g and 119 mg/g at initial concentration of 50 mg/l and pH=5 with adsorption dose of 0.8 g/L for 105 minutes at 300 rpm and temperature of 10°C from aqueous solutions. Also, it was revealed that the adsorption process had the highest correlation with the Langmuir model and secondorder kinetics, and the maximum adsorption capacity based on Langmuir model was 373.80 mg/g. Conclusion: According to the results, it was found that single-walled and multi-walled carbon nanotubes can be used as effective absorbents in the removal of penicillin G from aqueous solutions.
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Catteeuw, M., O. B. Pascottini, G. Opsomer, and A. Van Soom. "159 Effect of Commercial Embryo Holding Medium on Development and Quality of Immature Bovine Oocytes." Reproduction, Fertility and Development 30, no. 1 (2018): 219. http://dx.doi.org/10.1071/rdv30n1ab159.
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Bovine in vitro embryo production following ovum pick-up (OPU) in the field is hampered due to large time gaps between first and last OPU sessions. As oocytes will start immediate maturation, scheduling further manipulations makes the laboratory work laborious. There is a need for an easy and low-cost method that conserves the oocytes with full developmental capacity and allows scheduling laboratory work. In this regard, a commercial embryo holding medium (EHM; Syngro®; Bioniche Inc., WA, USA) was evaluated for conserving immature oocytes. Bovine immature oocytes (n = 2160) were collected from slaughterhouse animals by follicle aspiration and grouped per 60 and stored in 1 mL of EHM in 1-mL sterile glass osmometer tubes. Then, different temperatures [4°C, room temperature (RT), and 38.5°C] and different storage times (6, 10, 14 h) were assessed. After storage, oocytes were matured in TCM-199 supplemented with epidermal growth factor and gentamycin for 22 h. Fertilization was performed and zygotes (n = 1786) were cultured per 25 in 50 µL of SOF medium supplemented with 0.4% BSA and insulin, transferrin, and selenium. Control groups were included: immature oocytes (n = 1080) were not stored in EHM but immediately matured; fertilized and zygotes (n = 896) were cultured. Further, differential apoptotic staining was performed on a random subgroup of blastocysts to assess quality. Generalized fixed effect models were computed using R studio. Storage for 6 h showed a decrease in cleavage and blastocyst rate at 38.5°C (50 ± 3.9%; 11 ± 1.8%) compared with the control (78 ± 3.0%; 36 ± 2.8%). When increasing storage time, 38.5°C was not included; here, 4°C had a lower cleavage and blastocyst yield (47 ± 2.9%; 20 ± 3.3%) compared with the control (75 ± 2.5%; 41 ± 4.6%). For both 6 and 10 h, storage at RT resulted in similar cleavage (76 ± 3.4%; 74 ± 2.6%) and blastocyst rates (35 ± 2.7%; 40 ± 4.5%) as the control (P > 0.05). However, increasing storage to 14 h at RT decreased cleavage (61 ± 2.8%) and blastocyst yield (26 ± 2.5%) compared with the control (78 ± 2.4%; 39 ± 2.8%; P < 0.05). Evaluating embryo quality in all groups, no significant differences were found for any holding time or temperature of the EHM. To simulate OPU settings, EHM was also tested in 38 small groups of 10 immature oocytes that were subsequently matured, fertilized, and cultured. Based on the previous results, EHM storage was performed for 6 and 10 h at RT. Blastocyst development was not different between RT (19.8 ± 3.5%; 18.8 ± 3.6%) and the control (20.6 ± 3.6%; 18.3 ± 3.4%; P ≥ 0.05). To conclude, a commercial EHM can be used to conserve immature bovine oocytes without losing developmental capacity. Storage is recommended for no longer than 10 h and at RT in EHM. It opens new perspectives for practitioners, because this method is simple and low-cost; moreover, the start of maturation and subsequent in vitro embryo production process can be scheduled to avoid evening or night work at the laboratory.
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Bragulat, A. F., A. Gambini, M. B. Rodriguez, et al. "131 In vitro nuclear maturation and blastocyst developmental rates after intracytoplasmic sperm injection of equine oocytes held for 24 h at room temperature in Tyrode’s albumin lactate pyruvate-Hepes (TALP-h) or in a commercial embryo holding medium." Reproduction, Fertility and Development 33, no. 2 (2021): 173. http://dx.doi.org/10.1071/rdv33n2ab131.
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The interest in equine intracytoplasmic sperm injection (ICSI) for commercial and research applications has rapidly increased. Shipping immature oocytes at room temperature has been proven successful, and to identify the optimal conditions for holding oocytes, several mediums are being tested. The aim of this study was to compare the effect of holding equine oocytes in Tyrode’s albumin lactate pyruvate-Hepes (TALP-h, Bavister and Yanagimachi 1977 Biol. Reprod. 16, 228-237) medium or in commercial embryo holding medium (EHM, Syngro® Holding) on invitro nuclear maturation rates and pre-implantation embryo development after ICSI. Cumulus–oocyte complexes (COCs) were recovered from ovaries of slaughtered mares and assigned randomly in 2-mL cryovials with TALP-h or EHM, with a maximum of 30 oocytes per cryovial. COCs were shipped to the ICSI laboratory at 20 to 25°C for 24 to 28h followed by IVM for 24h in a humidified atmosphere of 5% CO2 in air at 38.5°C. Maturation medium was TCM-199 with 10% fetal bovine serum, 1μL mL−1 insulin-transferrin-selenium, 1mM sodium pyruvate, 100mM cysteamine, and 0.1mg mL−1 FSH. After mechanical cumulus cell removal, nuclear maturation rate was assessed using a stereomicroscope. Oocytes with an intact oolemma and extrusion of the first polar body (PB) were classified as mature, oocytes without a visible PB were considered immature, and oocytes without an intact oolemma were considered degenerate. Matured oocytes were subjected to ICSI without piezo-drill system (one proved stallion) in 20-μL droplets of TALP-h with a 7-μm glass sharp micropipette in an inverted microscope (Nikon Eclipse TE-300 microscope) using hydraulic micromanipulators (Narishige, Medical Systems). Presumptive ICSI zygotes were cultured in DMEM F12/Global Total® with 6% fetal bovine serum for 9 days at 38.5°C in a humidified atmosphere of 5% O2 and 5% CO2 in air. On Day 5 of culture, cleavage was recorded and medium was refreshed. Blastocysts rates were recorded on Day 7 and 9 of culture. Invitro nuclear maturation rates are shown in Table 1. We observed a significantly higher proportion of immature oocytes in the EHM group compared with the TALP-h group. After ICSI of some matured oocytes of each group, no significant differences were observed in cleavage or blastocyst rate (Table 1). Our results suggest that either TALP-h or commercial embryo holding medium are suitable for oocyte shipping and to support blastocyst development after ICSI. Table 1. Invitro nuclear maturation rates and pre-implantation embryo development after intracytoplasmic sperm injection (ICSI) Maturation rates Medium Oocytes Mature [n (%)] Immature [n (%)] Degenerate [n (%)] TALP-h 315 173 (54.9) 26 (8.3)a 116 (36.8) EHM 273 132 (48.4) 55 (20.1)b 86 (31.5) Total 588 305 (51.9) 81 (13.8) 202 (34.4) Embryo development ICSI (n) Cleaved [n (%)] Day 7 Blastocyst [n (%)] Day 9 Blastocyst [n (%)] TALP-h 35 23 (65.7) 7 (20) 9 (25.7) EHM 26 19 (73.1) 3 (11.5) 5 (19.2) Total 61 42 (68.9) 10 (16.4) 14 (23) a,bDifferent superscript letters indicate statistical significance (Fisher’s exact test, P&lt;0.05).
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Bragulat, A. F., A. Gambini, M. B. Rodriguez, et al. "131 In vitro nuclear maturation and blastocyst developmental rates after intracytoplasmic sperm injection of equine oocytes held for 24 h at room temperature in Tyrode’s albumin lactate pyruvate-Hepes (TALP-h) or in a commercial embryo holding medium." Reproduction, Fertility and Development 33, no. 2 (2021): 173. http://dx.doi.org/10.1071/rdv33n2ab131.
Full textAbstract:
The interest in equine intracytoplasmic sperm injection (ICSI) for commercial and research applications has rapidly increased. Shipping immature oocytes at room temperature has been proven successful, and to identify the optimal conditions for holding oocytes, several mediums are being tested. The aim of this study was to compare the effect of holding equine oocytes in Tyrode’s albumin lactate pyruvate-Hepes (TALP-h, Bavister and Yanagimachi 1977 Biol. Reprod. 16, 228-237) medium or in commercial embryo holding medium (EHM, Syngro® Holding) on invitro nuclear maturation rates and pre-implantation embryo development after ICSI. Cumulus–oocyte complexes (COCs) were recovered from ovaries of slaughtered mares and assigned randomly in 2-mL cryovials with TALP-h or EHM, with a maximum of 30 oocytes per cryovial. COCs were shipped to the ICSI laboratory at 20 to 25°C for 24 to 28h followed by IVM for 24h in a humidified atmosphere of 5% CO2 in air at 38.5°C. Maturation medium was TCM-199 with 10% fetal bovine serum, 1μL mL−1 insulin-transferrin-selenium, 1mM sodium pyruvate, 100mM cysteamine, and 0.1mg mL−1 FSH. After mechanical cumulus cell removal, nuclear maturation rate was assessed using a stereomicroscope. Oocytes with an intact oolemma and extrusion of the first polar body (PB) were classified as mature, oocytes without a visible PB were considered immature, and oocytes without an intact oolemma were considered degenerate. Matured oocytes were subjected to ICSI without piezo-drill system (one proved stallion) in 20-μL droplets of TALP-h with a 7-μm glass sharp micropipette in an inverted microscope (Nikon Eclipse TE-300 microscope) using hydraulic micromanipulators (Narishige, Medical Systems). Presumptive ICSI zygotes were cultured in DMEM F12/Global Total® with 6% fetal bovine serum for 9 days at 38.5°C in a humidified atmosphere of 5% O2 and 5% CO2 in air. On Day 5 of culture, cleavage was recorded and medium was refreshed. Blastocysts rates were recorded on Day 7 and 9 of culture. Invitro nuclear maturation rates are shown in Table 1. We observed a significantly higher proportion of immature oocytes in the EHM group compared with the TALP-h group. After ICSI of some matured oocytes of each group, no significant differences were observed in cleavage or blastocyst rate (Table 1). Our results suggest that either TALP-h or commercial embryo holding medium are suitable for oocyte shipping and to support blastocyst development after ICSI. Table 1. Invitro nuclear maturation rates and pre-implantation embryo development after intracytoplasmic sperm injection (ICSI) Maturation rates Medium Oocytes Mature [n (%)] Immature [n (%)] Degenerate [n (%)] TALP-h 315 173 (54.9) 26 (8.3)a 116 (36.8) EHM 273 132 (48.4) 55 (20.1)b 86 (31.5) Total 588 305 (51.9) 81 (13.8) 202 (34.4) Embryo development ICSI (n) Cleaved [n (%)] Day 7 Blastocyst [n (%)] Day 9 Blastocyst [n (%)] TALP-h 35 23 (65.7) 7 (20) 9 (25.7) EHM 26 19 (73.1) 3 (11.5) 5 (19.2) Total 61 42 (68.9) 10 (16.4) 14 (23) a,bDifferent superscript letters indicate statistical significance (Fisher’s exact test, P&lt;0.05).
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Amin, Mohammad Mehdi, Majid Hashemi, Karim Ebrahimpour, and Afsane Chavoshani. "Determination of parabens in wastewater and sludge in a municipal wastewater treatment plant using microwaveassisted dispersive liquid-liquid microextraction coupled with gas chromatography-mass spectrometry." Environmental Health Engineering and Management 6, no. 3 (2019): 215–24. http://dx.doi.org/10.15171/ehem.2019.24.
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Background: Due to the complexities involved in the extraction of micropollutants, the information regarding micropollutants like paraben in wastewater and sludge is scarce. The aim of this study was to adopt a microwave-assisted dispersive liquid-liquid micro-extraction (MADLLME) method for the extraction of parabens in municipal wastewater treatment plant (WWTP). Methods: A mixed stock solution of methyl-, ethyl-, propyl-, and butyl-parabens with concentration of 10 mg/mL were prepared in methanol. To validate this method, the limit of detection (LOD), limit of quantification (LOQ), linearity, and m/z were measured. To adopt this method in different condition, the effect of pH (3, 7, 9, and 12), microwave power (180, 300, 450, and 600 W), solvent type (methanol, acetone, methanol/water, acetone/water), and 1 g folorisil were assessed. After adopting MADLLME method, the paraben fate of this WWTP was evaluated through mass loading and emission. Results: The optimum performance of MADLLME method was observed at pH = 7, microwave power = 450 W, reaction time = 30 s, and methanol as the solvent. The total concentrations of four paraben metabolites in the WWTP ranged between 2505 ng/L in influent, 1953 ng/L in effluent, and 8.03 ng/g at wet weight sludge samples. The total mass loading and emission of four parabens in this WWTP was 0.672 mg/d/1000 people and 0.186 mg/d/1000 people, respectively. Conclusion: MADLLME method seems to be an excellent alternative, as a green extraction technique, for determining various groups of emerging micropollutants in different matrices.
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Pankiv, Zinoviy, and Olena Kalynych. "Ortsteins in the sod-podzolic pseudogleyed soils of the Beskydy Precarpathians." Visnyk of the Lviv University. Series Geography 53 (December 18, 2019): 277–87. http://dx.doi.org/10.30970/vgg.2019.53.10678.
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On the basis of morphological and laboratory-analytical researches it is established that in the profile of sod-podzolic pseudogleyed soils of the Beskydy Precarpathians are formed ortsteins that have clear outer contours, concentric inner structure with alternation of rust-red circles. Two ranges for the formation of ortsteins in the investigation soils were established: in the overiluvial part of the profile and the transition to the rock horizon. Within the НЕgl horizon, the content of ortsteins is 2.8 %, and in the fractional composition, the fraction is from 2.1 to 3.0 mm (37.5 %). The highest content of ortsteins (7.7 %) is characteristic of the Ehgl horizon, within which the fraction from 7.1 to 10.0 mm (27.2 %) prevails. Within the Pigl horizon, large ortsteins of 1.0 to 5.0 cm in size are oval and tubular with a concentric inner structure, and their content is 17.6 %. Ortsteins in the sod-podzolic pseudogleyed soils were formed as a result of alternation of redox conditions with the participation of specific, nonspecific microflora and glesish-eluvial, segregation processes of soil formation. The small ortsteins in the overiluvial part of the profile are the result of modern soil formation, and the large ones within the Pigl horizon are relict and associated with the early stages of soil formation in the Precarpathians. In order to identify the genesis and elemental composition, a plate of tubular ortstein with a diameter of 1.2 cm, which was selected from the Pigl horizon (220–240 cm), was made. In different parts of the plate, differing in colour, four points up to 1 μm in size (two against a light background and two against a dark one) were selected, within which elemental composition was determined by micro-X-ray spectrometry. The measurements were performed on a scanning electron microscope REM-106 (Ukraine) with a resolution of 5 nm and an energy-dispersive X-ray detector. The study of ortstein using a scanning electron microscope revealed that the formation of black rings within the tubular ortstein is due to an increase in the percentage of Manganese in 1.6–3.4, Aluminium in 1.4–2.3 and Calcium in 2.1–5.4 times. The percentage of Ferum in different parts of the ortstein is approximately the same, which determines its rusty-brown colour. Key words: ortsteins, sod-podzolic pseudogleyed soils, Beskydy Precarpathians, the accumulation factor, electron-scanning microscope.
Dissertations / Theses on the topic "EHGM 350"
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Al-Ajlouni, Dr-Eham [Verfasser]. "Environmental and health impacts of water resources in Jerash Governorate and Jordan / Dr-Eham Al-Ajlouni." München : GRIN Verlag, 2019. http://d-nb.info/1197230149/34.
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Wolstein, Katrin [Verfasser], Christoph [Akademischer Betreuer] Mischo, Klaus [Akademischer Betreuer] Fröhlich-Gildhoff, et al. "Selbstwirksam und kompetent? Zusammenhänge zwischen Selbstwirksamkeitserwartungen, Interaktionsverhalten und weiteren ausgewählten Kompetenzfacetten bei frühpädagogischen Fachkräften / Katrin Wolstein ; Gutachter: Christoph Mischo, Klaus Fröhlich-Gildhoff, Jan-Henning Ehm ; Christoph Mischo, Klaus Fröhlich-Gildhoff, Jan-Henning Ehm." Freiburg : Pädagogische Hochschule Freiburg, 2021. http://d-nb.info/1237495555/34.
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Peters, Svenja [Verfasser], Christoph [Akademischer Betreuer] Mischo, Klaus [Akademischer Betreuer] Fröhlich-Gildhoff, et al. "Kompetenzfacetten pädagogischer Fachkräfte in Kindertageseinrichtungen: Empirische Analysen zum professionellen Wissen, zu Einstellungen und zur Interaktionsqualität / Svenja Peters ; Gutachter: Christoph Mischo, Klaus Fröhlich-Gildhoff, Jan-Henning Ehm ; Christoph Mischo, Klaus Fröhlich-Gildhoff, Jan-Henning Ehm." Freiburg : Pädagogische Hochschule Freiburg, 2021. http://d-nb.info/1228621837/34.
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Kan-Dobrowsky, Natalia. "Generalized Multinomial CRR Option Pricing Model and its Black-Scholes type limit." Doctoral thesis, 2005. http://hdl.handle.net/11858/00-1735-0000-0006-B401-6.
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Wir bauen das verallgemeinerte diskrete Modell des zu Grunde liegenden Aktienpreisprozesses, der als eine bessere Annäherung an den Aktienpreisprozess dient als der klassische zufällige Spaziergang. Das verallgemeinerte Multinomial-Modell des Option-Preises in Bezug auf das neue Modell des Aktienpreisprozesses wird erhalten. Das entsprechende asymptotische Verfahren erlaubt, die verallgemeinerte Black-Scholes Formel zu erhalten, die die Formel als einen Begrenzungsfall des verallgemeinerten diskreten Option-Preis Modells bewertet.
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Soong, Poh Loong. "Development of a novel technology to engineer heart muscle for contractile and paracrine support in heart failure." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F03B-7.
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The human heart has poor endogenous regeneration. If myocytes are lost due
to injury, the myocardium is unable to restore its myocyte content and instead
undergoes compensatory hypertrophy and remodeling. Cardiac tissue
engineering aims to recreate and provide functional myocardium that replaces
the injured myocardium. In this study, human engineered heart muscle (EHM)
from cardiomyogenically differentiated human embryonic stem cells was
generated. EHMs consisted of elongated, anisotropically organized
cardiomyocyte bundles and responded “physiologically” to increasing calcium
concentrations. To generate large myocardium capable of encompassing the
ventricles, a novel process to systematically upscale the dimensions of
engineered myocardium to a humanized Biological Ventricular Assisted Device
(hBioVAD) was introduced. The hBioVADs formed a “pouch-like” myocardium at
rabbit heart dimensions and were beating spontaneously. Further enhancement
by biomimetic pulsatile loading generated “more mature” myocardium.
Additional paracrine functionality was integrated by generating insulin-like
growth factor-1 (IGF-1) secreting fibroblasts for tissue engineering applications.
IGF-1 release induced higher levels of Akt phosphorylation and hypertrophy in
cardiomyocytes resulting in increased force generation of EHM. Finally,
feasibility of “paraBioVAD” (IGF-1 cell line and cardiomyocytes) implantation
was demonstrated in a healthy rat model. Histological observations
demonstrated engraftment on the heart and the presence of vascular structures.
In conclusion, a humanized “paraBioVAD” technology for mechanic and
paracrine heart support was developed. Future studies will assess its
therapeutic utility in heart failure
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Löwe, Johannes. "Eine Finite-Elemente-Methode für nicht-isotherme inkompressible Strömungsprobleme." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-B3EE-B.
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