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Relevant bibliographies by topics / EIF4G1-RGG

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Academic literature on the topic 'EIF4G1-RGG'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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Journal articles on the topic "EIF4G1-RGG"

1

Bhatter, Nupur, Rajan Iyyappan, and Purusharth I. Rajyaguru. "Characterizing mutations in and genetic interactions of RGG-motif translation repressor Sbp1." Wellcome Open Research 3 (August 22, 2018): 102. http://dx.doi.org/10.12688/wellcomeopenres.14709.1.

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Background: Mechanisms of mRNA fate decisions play an important role in determining if a given mRNA will be translated, stored or degraded upon arrival to cytoplasm. Sbp1 is an important RGG-motif containing protein that is implicated in mRNA fate decisions since it can affect mRNA decapping and translation. Sbp1 represses translation by binding eIF4G1 through its RGG-motif and activates decapping when overexpressed. In order to understand the amino acids important for translation repression activity of Sbp1 we performed mutational analysis of Sbp1 combined with assessing its genetic interacti

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2

Bhatter, Nupur, Rajan Iyyappan, Gayatri Mohanan, and Purusharth I. Rajyaguru. "Exploring the role of RRM domains and conserved aromatic residues in RGG motif of eIF4G-binding translation repressor protein Sbp1." Wellcome Open Research 3 (September 17, 2021): 102. http://dx.doi.org/10.12688/wellcomeopenres.14709.3.

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Background: RNA binding proteins play crucial role in determining if a given mRNA will be translated, stored, or degraded. Sbp1 is an RGG-motif containing protein that is implicated in affecting mRNA decapping and translation. Sbp1 represses translation by binding eIF4G1 through its RGG-motif and activates decapping when overexpressed. In this report, we have assessed the genetic interaction of Sbp1 with decapping activators such as Dhh1, Pat1, and Scd6. We have further analyzed the importance of different domains and specific conserved residues of Sbp1 in its ability to cause over-expression

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3

Bhatter, Nupur, Rajan Iyyappan, and Purusharth I. Rajyaguru. "Exploring the role of RRM domains and conserved aromatic residues in RGG motif of eIF4G-binding translation repressor protein Sbp1." Wellcome Open Research 3 (February 6, 2020): 102. http://dx.doi.org/10.12688/wellcomeopenres.14709.2.

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Background: Mechanisms of mRNA fate decisions play an important role in determining if a given mRNA will be translated, stored or degraded upon arrival to cytoplasm. Sbp1 is an important RGG-motif containing protein that is implicated in affecting mRNA decapping and translation. Sbp1 represses translation by binding eIF4G1 through its RGG-motif and activates decapping when overexpressed. In this report we have assessed the genetic interaction of Sbp1 with decapping activators such as Dhh1, Pat1 and Scd6. We have further analyzed the importance of different domains and specific conserved residu

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4

Reuper, Hendrik, Benjamin Götte, Lucy Williams, et al. "Arabidopsis thaliana G3BP Ortholog Rescues Mammalian Stress Granule Phenotype across Kingdoms." International Journal of Molecular Sciences 22, no. 12 (2021): 6287. http://dx.doi.org/10.3390/ijms22126287.

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Stress granules (SGs) are dynamic RNA–protein complexes localized in the cytoplasm that rapidly form under stress conditions and disperse when normal conditions are restored. The formation of SGs depends on the Ras-GAP SH3 domain-binding protein (G3BP). Formations, interactions and functions of plant and human SGs are strikingly similar, suggesting a conserved mechanism. However, functional analyses of plant G3BPs are missing. Thus, members of the Arabidopsis thaliana G3BP (AtG3BP) protein family were investigated in a complementation assay in a human G3BP knock-out cell line. It was shown tha

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5

Togra, Chitra, Riya Dhage, and Purusharth I. Rajyaguru. "Tdh3 and Rom2 are functional modulators of a conserved condensate-resident RNA-binding protein, Scd6 in Saccharomyces cerevisiae." GENETICS, August 2, 2024. http://dx.doi.org/10.1093/genetics/iyae127.

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Abstract RGG-motif proteins play a crucial role in determining mRNA fate. Suppressor of clathrin deficiency 6 (Scd6) is a conserved RGG-motif containing RNP condensate-resident, translation repressor, and decapping activator protein in Saccharomyces cerevisiae. Identifying protein factors that can modulate Scd6 function is critical to understanding the regulation of mRNA fate by Scd6. In this study, using an approach that combined mRNA tethering assay with flow cytometry, we screened 50 genes for their role in modulating the translation repression activity of Scd6. We identified eight conserve

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6

Mohanan, Gayatri, Raju Roy, Hélène Malka-Mahieu, et al. "Genotoxic stress triggers Scd6-dependent regulation of translation to modulate the DNA damage response." EMBO Reports, April 24, 2025. https://doi.org/10.1038/s44319-025-00443-3.

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Abstract The role of mRNA translation and decay in the genotoxic stress response remains poorly explored. Here, we identify the role of yeast RGG motif-containing RNA binding protein Scd6 and its human ortholog LSM14A in genotoxic stress response. Scd6 localizes to cytoplasmic puncta upon cell treatment with various genotoxic agents. Scd6 genetically interacts with SRS2, a DNA helicase with an anti-recombination role in DNA damage repair under HU stress. Scd6 directly interacts with the SRS2 mRNA to repress its translation in cytoplasmic granules upon HU stress in an eIF4G1-independent manner.

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Dissertations / Theses on the topic "EIF4G1-RGG"

1

Gole, Shirish Gajanan. "Understanding the Role of Lsm Domain in Translation Repression Activity of RGG-motif Containing Protein Scd6." Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4286.

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Control of gene expression in eukaryotes is regulated at various steps such as transcription, translation and protein degradation. Translation repression of mRNA regulates protein levels and maintains cell homeostasis. Translation control allows for spatiotemporal regulation of gene expression which is required for development and differentiation in organisms. Deregulation of translation can result in disease conditions like cancer and neurodegenerative diseases. In yeast Saccharomyces cerevisiae, the RGG-motif protein Scd6 (Suppressor of Clathrin Deficiency 6) represses translation by binding

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