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Dissertations / Theses on the topic 'Elastin'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 June 2025

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1

Getie, Kebtie Melkamu. "Mass spectrometric characterization of elastin peptides and the effect of solar radiation on elastin." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=980155932.

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2

Bhanji, Tania. "Elastin in zebrafish and mice." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111938.

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The extracellular matrix is a vital component of the cardiovascular system, in that, it not only provides structural support but also plays a critical role in the maintenance of cellular stability. One of the major components of the vascular matrix is elastin, which confers vessels with the specialized property of stretch and recoil. Elastin deficiency has been implicated in many vascular diseases and determined experimentally to be a negative regulator of smooth muscle cell proliferation. In zebrafish, two elastin genes have been identified, which are actively expressed during development. Ba

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3

Ferron, Florence Joelle. "The implications of fibulin-5 on elastin assembly and its role in the elastic fiber /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101846.

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The extracellular matrix (ECM) is the material found surrounding the cells in a tissue. One component of the ECM is the elastic fiber, which confers the property of elasticity to its environment. Organs such as the lung, skin and major blood vessels have an abundance of elastic fibers so that they are able to expand and recoil. Elastic fibers are composed of two main components; elastin and microfibrils. Microfibrils are composed primarily of fibrillin-1 and provide a scaffold unto which tropoelastin monomers assemble. Elastic fibers interact with many other proteins in the ECM, one of which i

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4

Moore, Glynis Wilson. "Human aortic elastin : an examination of elastic lamellae fragmentation associated with ageing and atherosclerosis." Thesis, Queen's University Belfast, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356892.

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5

Dillon, Tara J. "Elastin metabolisim in human lung disease /." Title page, contents and abstract only, 1994. http://web4.library.adelaide.edu.au/theses/09PH/09phd5793.pdf.

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6

Smith, Kinley. "The distribution and function of elastin and elastic fibres in the canine cruciate ligament complex." Thesis, University of Liverpool, 2010. http://livrepository.liverpool.ac.uk/1437/.

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Anterior cruciate ligament rupture (ACL) is a major source of morbidity in the dog, leading to severe osteoarthritis of the knee joint and marked lameness. Following rupture, the ACL will not heal and in the dog, ACL rupture is thought to be the end stage of degenerative ligament disease (non-contact ACL injury). The extracellular matrix (ECM) of CLs has been extensively studied but little is known of the role of elastic fibres in the physiology of the ECM, the mechanics of CL function and in CL degeneration. Elastic fibres include polymers of fibrillins (microfibrils), bundles of microfibrils

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7

Chevallier, Stéphane. "Elastokines et Lactosylcéramide : cardioprotection et vieillissement." Thesis, Reims, 2011. http://www.theses.fr/2011REIMM203/document.

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La maladie cardiovasculaire la plus courante dans les pays industrialisés est la maladie coronarienne responsable d’une ischémie du tissu cardiaque pouvant conduire à l’infarctus du myocarde. Bien que les améliorations de la prise en charge aient considérablement réduit les délais de la reperfusion (seul remède à l’ischémie), l’ischémie/reperfusion (I/R) entraîne des dommages cellulaires et tissulaires ainsi qu’une diminution des capacités fonctionnelles du coeur. Il existe néanmoins des systèmes de cardioprotection endogènes (comme le préconditionnement (préC) ou le postconditionnement (postC

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8

Chalmers, Gavin William Geddes. "A comparative study of the swelling and mechanical properties of vertebrate elastins." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27856.

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The swelling-temperature compensation hypothesis as proposed by Gosline and French (1979) is examined by investigating the physical and mechanical properties of an evolutionary series of vertebrate elastins. Temperature-dependent swelling, low water contents and thermodynamics typical of hydrophobic systems were observed for all elastins except salmon. Salmon elastin, on the other hand, showed temperature-independent swelling and a high water content. Thermodynamic analysis showed that salmon elastin still contained a hydrophobic component. The swelling-temperature compensation hypothesis sug

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9

Georgilis, Evangelos. "Engineering of Thermoresponsive Diblock Elastin-like Polypeptides." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0444.

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La thèse présentée porte sur l’ingénierie de diblocs de polypeptides à base de motifs élastine (ELPs) susceptibles de s’auto-assembler sous forme de nanoparticules après modification chimique de certains résidus. La stratégie inclue le développement de diblocs d’ELPs composés d’un bloc hydrophobe comportant l’isoleucine en position hôte, fusionné à l’extrémité N-terminale avec un bloc contenant des résidus méthionine chimiosélectivement modifiables. Des modifications du groupement thioéther permettent en effet l’hydrophilisation du segment ELP correspondant ainsi que l’introduction de groupeme

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10

Alanazi, Hamdan Noman. "Characterization of Elastin-Like Polypeptides Using Viscometry." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1311026986.

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11

Green, Ellen Marie. "Mechanisms of elasticity in elastic proteins." Thesis, University of Exeter, 2012. http://hdl.handle.net/10036/4058.

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This thesis investigates the mechanical properties of the elastic proteins isolated by cyanogen bromide digestion from lamprey cartilages and compares them with the mammalian protein, elastin. Thermomechanical testing and measurements of the effects of hydrophobic solvents on mechanics are used to determine the energetic and entropic contributions to the mechanical properties and the role of solvent interactions. Raman microspectrometry is shown to be a valuable tool in determining the secondary structure of the proteins, their interactions with water and molecular-level effects of mechanical

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12

Monteiro, Priscilla de Souza. "O efeito do hipotiroidismo experimental sobre os componentes da matriz extracelular de aortas torácicas de ratos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-29012013-081814/.

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O objetivo deste estudo foi investigar os efeitos do hipotiroidismo experimental sobre o leito vascular da aorta torácica. Para a análise histológica foram realizadas colorações de hematoxilina-eosina, picrosirius e Weigert. Na análise de expressão proteica, foram realizadas as quantificações para colágeno I e III, elastina, MMP-9 e MMP-2, TIMP-1 e TIMP-2. As análises histológicas demonstraram uma diminuição da AST das aortas dos animais hipo e juntamente a esta alteração, foi constatada a diminuição da expressão proteica de colágeno do tipo I. Em relação à elastina, foi possível observar aume

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13

Wang, Ziyu. "Development of electrospun tropoelastin-polyglycerol sebacate scaffolds for soft tissue engineering applications." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27880.

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Soft tissue damages from disease, trauma, and ageing often have limited regeneration capability, leading to the loss of tissue functions and impacting the quality of life. Repair tissue damage using polymeric materials can alleviate issues such as donor shortage and transplantation rejection associated with undesirable immune responses. This project developed tropoelastin-polyglycerol sebacate (tropelastin-PGS) scaffolds with a spectrum of 3D microstructures, tuneable mechanical properties, controllable degradation profile, and excellent biocompatibility suitable for diverse soft tissue applic

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14

Isenburg, Jason C. "Stabilization of vascular elastin by treatment with tannins." Connect to this title online, 2006. http://etd.lib.clemson.edu/documents/1171041760/.

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15

Kothapalli, Chandrasekhar R. "Cues for cellular assembly of vascular elastin networks." Connect to this title online, 2008. http://etd.lib.clemson.edu/documents/1219849109/.

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16

Wilcox, Donna. "The role of cathepsin L in elastin degradation." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277118.

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17

Zhou, Mingjun. "Elastin-Like Peptide Dendrimers: Design, Synthesis, and Applications." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/101661.

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Elastin like peptides (ELPs)—derived from the protein elastin—are widely used as thermoresponsive components in biomaterials due to their LCST (lower critical solution temperature) behavior at a characteristic transition temperature (Tt). While linear ELPs have been well investigated, few reports focused on branched ELPs. Using lysine (Lys, with an additional side-chain amine) as branching units, ELP dendrimers were synthesized by solid-phase peptide synthesis (SPPS) with up to 155 amino acid residues. A secondary structure change with decreasing ratio of random coil and increasing ratio of β-

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18

Monfort, Dagmara Anne. "Recombinant Elastin Based Nanoparticles for Targeted Gene Therapy." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6627.

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Gene therapy is a technique used to inactivate, replace or insert a corrective copy of a defective gene in order to help diseased tissues to function properly. Gene therapy is a promising treatment for many diseases cancer, cystic fibrosis, and Parkinson’s. There are different methods to introduce a gene to the cell; one of them is the use of viruses. Among viruses, lentiviruses have been popular vectors for gene delivery due to their efficient mode of gene delivery. However, the non-specific delivery of genes associated with viruses may result in undesirable side effects. Here, we propose a h

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19

Wu, Wendy J. "Structure and properties of recombinant human tropoelastin, domain 26A and mutant forms." Thesis, The University of Sydney, 2000. https://hdl.handle.net/2123/27598.

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This thesis outlines a series of investigations of the structure and properties of full-length tropoelastin, intermolecular interactions of tropoelastin and the effects of an inherited disorder on the association properties of human tropoelastin.

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20

Grant, Tyler M. "Microstructural deformation of tendon." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:0ad70415-af7a-4b97-a93a-d17a73d8ff44.

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Tendon disorders are painful, disabling, and a major healthcare problem, with millions of people affected by tendon injuries each year. Current treatment strategies are inadequate and knowledge of the underlying mechanobiological mechanisms is required to develop novel therapies. Although the tissue–level properties of tendon are well–documented there remains a lack of understanding of the deformation mechanisms of this complex tissue. Therefore, the aim of this thesis is to characterize the microstructural deformation of tendon through biological imaging, mechanical testing, and computational

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21

Patel, Dhaval Pradipkumar. "Novel PEG-elastin copolymer for tissue engineered vascular grafts." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45811.

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The growing incidences of coronary artery bypass graft surgeries have triggered a need to engineer a viable small diameter blood vessel substitute. An ideal tissue engineered vascular graft should mimic the microenvironment of a native blood vessel, while providing the adequate compliance post-implantation. Current vascular graft technologies lack the ability to promote vascular ECM deposition, leading to a compliance mismatch and ultimately, graft failure. Hence, in order to engineer suitable vascular grafts, this thesis describes the synthesis and characterization of novel elastin mimetic pe

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22

Kambow, Sumit H. "Characterization of Elastin-like Polypeptide Micelles Using Capillary Viscometry." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1337605892.

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23

Lindsay, Amanda. "Behaviour of alpha-elastin in bulk and at aqueous surfaces." Thesis, University of Exeter, 2011. http://hdl.handle.net/10036/3222.

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24

Tampelini, Flávio Silva. "Efeito do exercício fisico aeróbio sobre os componentes fibroelástico e colágeno da aorta de ratos normotensos e hipertensos, sedentários e treinados." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-30052008-120037/.

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O objetivo deste trabalho foi avaliar o efeito do exercício físico aeróbio sobre alterações morfológicas ocorridas na parede da aorta abdominal de animais hipertensos (SHR) e normotensos (WKY), sedentários (S) e treinados (T). Ratos SHR e WKY foram utilizados, que consistia de quatro grupos divididos em WKYS, WKYT, SHRS, SHRT. O treinamento durou 13 semanas, sendo 5 horas por semana, 1 hora por dia. Os resultados deste estudo mostraram que o exercício físico foi eficaz em reduzir a pressão arterial, a freqüência cardíaca e a razão parede/luz, bem como em aumentar a quantidade de fibras elástic

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25

Balderrama, Fanor Alberto. "Incorporation of recombinant fibronectin into genetically engineered elastin-based polymers." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31640.

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Thesis (M. S.)--Bioengineering, Georgia Institute of Technology, 2010.<br>Committee Chair: Chaikof, Elliot; Committee Member: Conticello, Vincent; Committee Member: Jo, Hanjoong. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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26

Scott, Michael J. "The elastin and collagen microstructure of aortic heart valve cusps." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ32327.pdf.

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27

Chen, Vivian Wenjun. "Human elastin peptide-coated synthetic materials in blood-contacting applications." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0005/MQ45895.pdf.

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28

Chen, Li Hsuen. "Identification of potential exosite in cathepsin V necessary for elastin degradation." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/4069.

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Besides collagen, elastin is the most common connective tissue structural protein in vertebrates and similar to collagen relatively resistant to non-specific degradation. Typical elastolytic proteases are the serine-dependent pancreatic and leukocyte elastases, the Zn-dependent matrix metalloproteinase 12, and several lysosomal cysteine proteases. Among the cysteine cathepsins, cathepsins S, K and V are highly potent elastases with cathepsin V displaying the highest activity among all known mammalian elastases. Despite a shared amino acid sequence identity of over 80% between cathepsins V and

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29

Ravi, Swathi. "Recombinant elastin analogues as cell-adhesive matrices for vascular tissue engineering." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/42728.

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Biomimetic materials that recapitulate the complex mechanical and biochemical cues in load-bearing tissues are of significant interest in regenerative medicine and tissue engineering applications. Several investigators have endeavored to not only emulate the mechanical properties of the vasculature, but to also mimic the biologic responsiveness of the blood vessel in creating vascular substitutes. Previous studies in our lab generated the elastin-like protein polymer LysB10, which was designed with the capability of physical and chemical crosslinks, and was shown to display a range of elastome

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30

Leonard, Alex. "Elastin Like Polypeptides as Drug Delivery Vehicles in Regenerative Medicine Applications." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/5981.

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Elastin like polypeptides (ELPs) are a class of naturally derived biomaterials that are non-immunogenic, genetically encodable, and biocompatible making them ideal for a variety of biomedical applications, ranging from drug delivery to tissue engineering. Also, ELPs undergo temperature-mediated inverse phase transitioning, which allows them to be purified in a relatively simple manner from bacterial expression hosts. Being able to genetically encode ELPs allows for the incorporation of bioactive peptides and functionalization of ELPs. This work utilizes ELPs for regenerative medicine and drug

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31

Hillery, Claire. "The role of elastin in the mechanical properties of conduit arteries." Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417835.

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32

Neocleous, Vassos K. "UVR effects on collagen and elastin gene products in mouse skin." Thesis, London Metropolitan University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287619.

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33

Xiao, Ye. "Synthesis and self-assembly of polysaccharide-b-elastin-like polypeptide bioconjugates." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0172.

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L’association de polysaccharides naturels et de polypeptides recombinants de type élastine (ELP) dans des structures de copolymères à blocs doit permettre d’accéder à des matériaux possédant des propriétés d’auto-assemblage sous l’action de stimuli et potentiellement bioactifs. Nous avons réalisé et présentons ici la synthèse d'une série de bioconjugués polysaccharide-b-ELP, dans lesquels 4 polysaccharides hydrophiles différents ont été couplés à l'extrémité N-terminale de l’ELP par "chimie click".Ces bioconjugués ont été caractérisés par RMN 1D et 2D, SEC et FTIR. Leur thermo-sensibilité et l

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34

Ghoorchian, Ali. "Modification of Behavior of Elastin-like Polypeptides by Changing Molecular Architecture." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1336745204.

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35

Petitdemange, Rosine. "Chemoselective modifications of recombinant elastin-like polypeptides : tuning thermosensitivity and bioactivity." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0360/document.

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La thèse présentée porte sur la préparation de dérivés de polypeptides recombinant à base de motifs élastine (ELPs) ainsi que sur l'étude de leurs propriétés physicochimiques et biologiques. Des ELPs contenant des résidus méthionine ont été modifiés de manière chimiosélective soit en utilisant des halogénures d'alkyle ou différents époxydes, soit par oxydation des résidus méthionine. La caractérisation par RMN et par spectrométrie de masse des composés obtenus a permis de confirmer leur fonctionnalisation quantitative. L'étude de la réponse en température de ces dérivés d'ELP par des mesures d

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36

Kawabata, Shingo. "The development of a novel wound healing material, silk-elastin sponge." Kyoto University, 2019. http://hdl.handle.net/2433/243272.

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37

Sbruzzi, Ivanete Chaves. "Estudo de marcadores polimórficos da região 7q11.23 para o diagnóstico da síndrome de Williams-Beuren." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-29012007-133658/.

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INTRODUÇÃO: A síndrome de Williams-Beuren (SWB) resulta de uma deleção de aproximadamente 1.5 Mb na região 7q11.23. A haploinsuficiência ocasiona alterações do desenvolvimento neurológico assim como malformações em múltiplos sistemas. OBJETIVOS: Testar utilidade de marcadores polimórficos para o diagnóstico da síndrome, determinar a proporção de pacientes com microdeleção, comparar características clínicas entre pacientes com e sem microdeleção e investigar origem parental. MÉTODOS: Selecionamos 32 pacientes com avaliação clínica para SWB atendidas no ICr. Critérios de inclusão: presença de di

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38

Krex, Dietmar, Inke R. König, Andreas Ziegler, Hans K. Schackert, and Gabriele Schackert. "Extended Single Nucleotide Polymorphism and Haplotype Analysis of the elastin Gene in Caucasians with Intracranial Aneurysms Provides Evidence for Racially/Ethnically Based Differences." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135316.

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Background: There is growing evidence that genetic variants have an impact on the pathogenesis of intracranial aneurysm (IA). Recently, the genetic locus around the elastin gene (7q11) has been identified as linked to IA in a Japanese population. Our aim was to confirm these results in Caucasian populations. Methods: We conducted a case-control study in 120 Caucasian patients with IA and 172 controls to investigate 8 single nucleotide polymorphisms (SNPs) and various haplotypes within the elastin gene, which were frequently found and associated with the phenotype in the Japanese populations. R

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39

Winfield, Kaye R. "Extraction of desmosines from urine : an indicator for inflammatory lung damage /." Connect to this title, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0059.

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40

Vrhovski, Bernadette. "Recombinant human tropoelastin : production, properties and interactions." Thesis, The University of Sydney, 1997. https://hdl.handle.net/2123/27631.

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41

Moraes, Renato de. "Utilização da membrana de elastina associada a hidroxiapatita e proteína morfogenética óssea no reparo de defeitos cranianos de ratos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-20082018-134054/.

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Devido as limitações relacionadas ao emprego do enxerto autólogo, o uso dos biomateriais poliméricos naturais tornou-se uma opção viável em terapias regenerativas do tecido ósseo. O objetivo desse trabalho é avaliar de forma qualitativa e quantitiva a contribuição da membrana de elastina utilizada isoladamente ou em associação a hidroxiapatita e proteína morfogenética óssea, no reparo de defeitos ósseos no crânio de ratos. Foram utilizados 49 ratos (Rattus norvegicus, Wistar), machos, com peso aproximado de 330 gramas e 4 meses de idade. Os animais foram submetidos ao procedimento cirúrgico pa

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42

Dahal, Shataakshi. "Stem Cells Based Elastic Matrix Regeneration for Small Abdominal Aortic Aneurysms (AAAs) Repair." Cleveland State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=csu1599137475237285.

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Dahal, Shataakshi. "Stem Cells Based Elastic Matrix Regeneration for Small Abdominal Aortic Aneurysms (AAAs) Repair." Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1599137475237285.

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44

Martinez, Adam W. "Design and development of an elastin mimetic stent with therapeutic delivery potential." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45926.

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Stenting remains a common treatment option for atherosclerotic arteries. The main drawback of early stent platforms was restenosis, which has been combated by drug eluting stents; however, these stents have suffered from a higher incidence of late stage thrombosis. To address current stenting limitations, the major research focuses have been the development of the next generation of drug eluting stents and first generation bioabsorbable stents. The main objective of this dissertation was the design and development of a new class of bioabsorbable stent composed of elastin mimetic protein polyme

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45

Tang, Mingjie. "SYNTHESIS AND CHARACTERIZATION OF pH-RESPONSIVE ELASTIN-LIKE POLYPEPTIDES WITH DIFFERENT CONFIGURATIONS." Cleveland State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=csu1376784321.

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46

Helm, Eric. "Solute Partitioning in Elastin-like Polypeptides: A Foundation for Drug Delivery Applications." Cleveland State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=csu1450790146.

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47

WAN, JIA HONG. "Investigation into the phase separation behavior of concentrated elastin-like polypeptide solutions." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1471923273.

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48

Sallach, Rory Elizabeth. "Recombinant elastin-mimetic protein polymers as design elements for an arterial substitute." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/29614.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Elliot Chaikof; Committee Member: Marc Levenston; Committee Member: Robert Nerem; Committee Member: Vincent Conticello; Committee Member: Yadong Wang. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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49

Ebert, Regina. "Möglichkeiten der Epithelisierung einer Koriumersatzmembran aus Kollagen-Elastin : Experimente an DA-Ratten /." Aachen : Mainz Verlag, 2002. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=009897917&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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50

Chow, Ming-Jay. "Mechanics and mechanobiology of arteries: contributions and interactions of collagen and elastin." Thesis, Boston University, 2013. https://hdl.handle.net/2144/10966.

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Thesis (Ph.D.)--Boston University<br>The dynamic mechanical behavior of arteries is essential to a properly functioning vascular system. Within the arterial extracellular matrix (ECM), the organization of collagen and elastin leads to the bulk of the passive mechanical behavior of the tissue. While remodeling of the ECM occurs naturally in healthy arteries to maintain normal functioning, vascular diseases often create different chemical and mechanical conditions that cause significant changes in structure and adverse effects on the mechanical behavior. The goal of this dissertation is to under

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