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Dissertations / Theses on the topic 'Electrões de Auger'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Auday, Eran. "DNA dose absorption calculations for auger electrons therapy using EGS4 Monte Carlo system /." [Beer Sheva] : Ben Gurion University of the Negev, 2007. http://aranne5.lib.ad.bgu.ac.il/others/AudayEran.pdf.

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2

Fondell, Amelie. "Two-Step Targeting for Effective Radionuclide Therapy : Preclinical Evaluation of 125I-labelled Anthracycline Delivered by Tumour Targeting Liposomes." Doctoral thesis, Uppsala universitet, Enheten för biomedicinsk strålningsvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159365.

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For the treatment of cancer, Auger-electron emitting radionuclides are strongly dependent on their close proximity to DNA to utilize the local therapeutic potential of the Auger electrons. This thesis investigates a two-step targeting approach that uses targeting liposomes for the delivery of an Auger-electron emitter, 125I, coupled to a DNA-binding compound, Comp1, to the tumour-cell DNA. In the first step the liposome targets overexpressed cell-surface receptors. Receptors belonging to epidermal growth factor receptor (EGFR) family are overexpressed in a number of different cancers and are t

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3

Gineste, Thomas. "Émission électronique sous impact d'électrons : applications spatiales." Thesis, Toulouse, ISAE, 2015. http://www.theses.fr/2015ESAE0026/document.

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L‘objectif de la thèse consiste à caractériser expérimentalement sous vide les propriétés d’émission électronique de matériaux utilisés dans des applications spatiales tels que l’argent et l’aluminium dans leur état de contamination naturel, afin de fournir des données précises à la communauté du spatial tout en contribuant à comprendre et quantifier le rôle joué par la contamination naturelle sur leurs propriétés d’émission électronique. Afin de répondre à cet objectif, un moyen expérimental nommé CELESTE permettant de caractériser les différentes propriétés d’émission électronique de ces mat

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4

Rathje, Claudia Cattoni. "Novel approaches to target infectious diseases : the utility of Auger electrons and scFvs for imaging and control." Thesis, University of Kent, 2014. https://kar.kent.ac.uk/47432/.

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With an increasing number of infectious agents resistant to one or more existing antibiotics, there is a global requirement for new therapeutics. One possible method for treatment of infectious diseases proposed in this study is the adaptation of a technique developed for cancer treatment, targeted radionuclide therapy, with particular interest in Auger electron radiation. Auger electrons are short range and low energy particles emitted from a range of radioactive isotopes. As a targeting agent, the antimicrobial peptide fragment UBI 29-41 was used. Antimicrobial peptides have a broad range of

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5

Smit, B. S. "Cellular radiotoxicity of iodine-123." Thesis, Stellenbosch : Stellenbosch University, 2000. http://hdl.handle.net/10019.1/51646.

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Thesis (MSc)--University of Stellenbosch, 2000.<br>ENGLISH ABSTRACT: The Auger electron emitter iodine-123 was examined in the form of 4- [12311iodoantipyrineand as [12311Nal for its effectiveness in killing cells of different sensitivity to photon irradiation. Micronucleus assays showed that 4- [12311iodoantipyrineis two to three times more effective in cell inactivation than C2311Nai.This can be attributed to the fact that antipyrine, for reason of its lipid solubility, can enter cells and can reach the cell nucleus, whereas C231]Nai is excluded from the cytoplasm. The differential ta

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6

Fourie, Hein. "Microdosimetric studies of Auger electrons from DNA-incorporated 123-I using the micronucleus assay and the Geant4 Monte Carlo simulation tookit." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/95801.

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Thesis (MSc)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: This study’s focus is on the determination and quantization of radiation damage on a cellular level due to the decay of the Auger electron-emitting 123I and the replication of this energy deposition using Geant4 Monte Carlo simulations. The relatively short half-life of 123I (13.2 hours) makes it ideal for studies of Auger electrons which induce biological damage similar to that of high linear energy transfer radiations, when permitted to deposit their energy in close proximity to DNA. Due to small cellular dimensions, direct do

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7

Punzet, Robert. "99mTc-HYNIC-DAPI-DNA-Bindungsnachweis und Nachweis von DNA-Doppelstrangbrüchen durch 99mTc-HYNIC-DAPI mittels Agarose-Gelelektrophorese." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-146456.

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Hintergrund: Ein sehr häufig in der nuklearmedizinischen Diagnostik genutztes Radionuklid ist 99mTc. Es emittiert Gammastrahlung mit einer relativ niedrigen Energie (140 keV) und hat eine kurze Halbwertszeit von 6 h. Zusätzlich zur Gammastrahlung entstehen bei jedem Zerfall von 99mTc Auger-Elektronen. Diese niederenergetischen Elektronen, sehr kurzer Reichweite verfügen über einen hohen LET und erzeugen somit eine ausreichende Energiedeposition, um direkte DSB zu erzeugen. Bei Untersuchungen zu Chemotoxizität und Radiotoxizität mit Zellexperimenten gilt es eine Vielzahl an verschiedenen Schutz

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8

Martin, Corinne. "Modélisation des dommages radioinduits sur l'ADN : prise en compte des radicaux libres et des réparations primaires." Toulouse 3, 2003. http://www.theses.fr/2003TOU30050.

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9

Bensaoula, Amar. "Spectroscopies des électrons Auger et des pertes d'énergie, et structures fines associées : application aux interfaces Co-Si et Fe-Si." Grenoble 1, 1990. http://www.theses.fr/1990GRE10073.

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Habituellement les etats electroniques vides au-dessus du niveau de fermi sont etudies par l'absorption x (xas) ou par la photoemission inverse (ipe). De meme pour sonder l'ordre local dans les materiaux, la spectroscopie usuellement utilisee est l'exafs. On peut cependant mettre en uvre d'autres techniques spectroscopiques de laboratoire basees sur les pertes d'energie electronique pres des seuils d'ionisation (eelnes: electron energy-loss near adge structure) ou loin des seuils (eelfs: electron energy-loss fine structure) pour acceder respectivement aux proprietes electroniques (etats vides)

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10

DEMUYNCK, LAURENT. "Nucleation et croissance de couches diamant elaborees par cvd sur differents substrats de silicium. Etude par spectroscopies d'electrons : electrons auger (aes), photoemission x (xps), pertes d'energies (els)." Université Louis Pasteur (Strasbourg) (1971-2008), 1995. http://www.theses.fr/1995STR13228.

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Les couches de diamant obtenues par la technique cvd font l'objet de nombreuses recherches en vue d'applications industrielles. Les proprietes des films diamant etant fortement liees a la nature des joints de grains, les applications electroniques et optiques sont difficilement realisables tant que l'heteroepitaxie des films n'est pas atteint. La nucleation et la croissance du diamant sont fortement influencees par la presence du carbone et/ou de defauts a la surface du support et passent par plusieurs etapes (interface carbure, formation de sites de nucleation, diffusion de surface)

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11

CONSTANT, LAURENT. "Nucleation et croissance de couches diamant elaborees par hfcvd sur cuivre polycristallin et monocristallin (111) etudiees par spectroscopies electroniques : photoemission x (xps), electrons auger (aes), pertes d'energie (eels)." Université Louis Pasteur (Strasbourg) (1971-2008), 1997. http://www.theses.fr/1997STR13082.

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Nous avons synthetise du diamant par le procede de depot chimique en phase gazeuse par filaments chauds (hfcvd) sur du cuivre polycristallin et monocristallin (111). Dans un premier temps, nous utilisons la microscopie electronique a balayage (meb) pour definr les principaux parametres de la nucleation et de la croissance. Ensuite, la croissance du diamant est etudiee par spectroscopie des electrons auger (aes) et spectroscopie de photoemission x (xps), directement connectees a la chambre de synthese. L'analyse des transitions auger c kvv et des intensites relatives du pic c1s nous permet de p

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12

Tea, Eric. "Résolution de l'equation de transport de boltzmann par une approche Monte Carlo (full-band), application aux cellules solaires à porteurs chauds et aux composants ultra-rapides." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00670433.

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Cette thèse est consacrée à l'étude de la dynamique des porteurs de charges sous forte concentration. La méthode Monte Carlo " Full-Band " a été utilisée pour la modélisation du transport et la relaxtion des porteurs de charge dans les semi-conducteurs III-V (GaAs, InAs, GaSb, In0.53Ga0.47As et GaAs0.50Sb0.50). Les structures électroniques ont été calculées par la Méthode des Pseudo-potentiels Non-Locaux Empiriques, ce qui a notamment permis de traiter le cas de l'alliage ternaire GaAs0.50Sb0.50 dans une approche de type Cristal Virtuel, matériau qui souffre d'un manque de caractérisations exp

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13

Jaouen, Thomas. "Isolant dans la limite ultra-mince : propriétés électroniques et barrières tunnel de MgO." Phd thesis, Université Rennes 1, 2012. http://tel.archives-ouvertes.fr/tel-00772602.

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Présentes dans de nombreux dispositifs comme les jonctions tunnel magnétiques ou les systèmes cluster/oxyde utilisés en catalyse hétérogène, les interfaces métal/oxyde présentent des propriétés spécifiques venant du raccordement entre deux matériaux de structure atomique et surtout de structure électronique très différentes. Ce projet de recherche repose sur l'étude, par diverses techniques de spectroscopies de photoémission, de la géométrie et de la structure électronique aux interfaces MgO/Ag(001) pour des épaisseurs d'oxyde subnanométriques. Nous avons, tout d'abord, montré que la valeur de

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14

Tavares, Adriana Alexandre dos Santos. "Análise dos efeitos terapêuticos dos electrões de Auger em culturas de células." Dissertação, 2009. http://hdl.handle.net/10216/58490.

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15

Tavares, Adriana Alexandre dos Santos. "Análise dos efeitos terapêuticos dos electrões de Auger em culturas de células." Master's thesis, 2009. http://hdl.handle.net/10216/58490.

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16

Esteves, Teresa. "Complexos de elementos emissores de radiação gama e de electrões Auger para diagnóstico e/ou terapia do cancro." Doctoral thesis, 2011. http://hdl.handle.net/10451/3917.

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Tese de doutoramento, Química (Química Inorgânica), Universidade de Lisboa, Faculdade de Ciências, 2011<br>Novos ligandos do tipo pirazolo-diamina com as unidades intercaladoras alaranjado de acridina (L1, L3), 9-acridina ácido carboxílico (L2, L4) e antraceno (L5), na posição 4 do anel de pirazolilo, foram sintetizados e caracterizados. A sua coordenação à unidade fac-[M(CO)3]+ (M=Re,99mTc) originou complexos do tipo fac-[M(CO)3(κ3-L)]+/2+ em que: L=L1: M= Re (Re1), 99mTc (Tc1); L=L2: M= Re (Re2), 99mTc (Tc2); L=L3: M= Re (Re3), 99mTc (Tc3); L=L4: M=Re (Re4); L=L5: M= Re (Re5), 99mTc (Tc

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17

Rosa, Annica de Barros. "Multifunctional organometallic compounds for Auger therapy." Master's thesis, 2014. http://hdl.handle.net/10362/13752.

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Abstract Auger emitters gained significant interest in the past years due to the favorable suitability for target therapy at cellular level.Among Auger emitters, 99mTc seems like the most appealing candidate for this task due to its great advantages regarding low cost, high availability and almost ideal radiochemical properties. The short range of Auger electrons demands that the radionuclide must be as close as possible to the target, usually the nuclear DNA, in order to cause significant therapeutic effects. Thus, the search f

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18

Moruri, Letty Dimpho. "Cellular damage by Auger electrons from¹²³ / Letty Dimpho Moruri." Thesis, 2005. http://hdl.handle.net/10394/11325.

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Auger electrons have the potential for therapy mainly because of their short range and high level of toxicity. Biological effects of these electrons are critically dependent on the cellular and subcellular localization of their emitters. In this study 123I was used due to its relatively short half-life (13.2 h) and ideal y-ray energy (Ey=I59 keV). The short half-life is advantageous since it allows significant accumulation of disintegrations at normal physiological conditions without the need to freeze cells as required when long lived isotopes such as 1251 (T1/2=60.1 days) are used. The main

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19

Tu, Tzu-Hui, and 杜姿慧. "Strand Breaking of Plasmid DNA by Auger electrons from intercalated 99mTc." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/49768373437293850735.

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碩士<br>國立清華大學<br>生醫工程與環境科學系<br>97<br>Auger electrons are impression as a potential and prospective gene therapy becaused of its high energy transfer (LET 4-26 keV/μm). There were many studies on DNA breakage induced by Auger electrons, and most of them applied 125I to the experiment rarely with 99mTc. In this study, we developed a new application of 99mTc radionuclide as the Auger electron emitter to obtain more information about the correlation between the dose of 99mTc and DNA breakage with various conditions of time, dose of 99mTc, and proportion of Dimethyl sulfoxide (DMSO). Quantification

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20

Howell, Roger Wells. "Radiobiological effects of Auger electrons in the decay of platinum-195m." 1987. https://scholarworks.umass.edu/dissertations/AAI8805929.

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The metastable radionuclide Pt-195m decays predominantly by internal conversion (IC) with a half-life of 4 days. The vacancies created in the inner atomic shells by the primary IC decay modes result in copious emission of low energy Auger electrons. The biological effects of these electrons, which have ranges of subcellular dimensions, are of interest to basic and applied radiation biophysics. Using radiolabeled platinum complexes which bind to DNA, one can examine the effect of Pt-195m Auger cascades close to the DNA. Trans-Pt-195m (trans-dichlorodiammineplatinum (II); specific activity 0.5 m

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21

Li, Ying-Hsuan, and 李盈萱. "Analysis of radiation dosage of Auger electrons from I-127 induced by external X-ray : a Monte Carlo simulation." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/41305569344079738418.

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碩士<br>高雄醫學大學<br>醫學影像暨放射科學系碩士在職專班<br>104<br>As the clinical prevalence of thyroid-related diseases increase, radioactive targeted therapy in cancer treatment is becoming a trending topic. Utilization of 131I-emitted β particles after oral ingestion is one of the more commonly adopted methods today.This study explored the efficacy and efficiency of Auger electrons in treatment with Monte Carlo simulation. The radiation dosage of Auger electron emission from 127I and other iodine nuclides following photoelectric absorption of external X-rays were evaluated. This study was performed using the

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22

Götze, Pauline Johanna. "Radiosensitivierung durch iodhaltige DNA-bindende Liganden: Charakterisierung der Auger-Elektronen-Verstärkung durch verschiedene Strahlenqualitäten und Modulatoren." Doctoral thesis, 2018. https://tud.qucosa.de/id/qucosa%3A33497.

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Hintergrund: Die Entwicklung von Therapieprinzipien zur Behandlung von Krebserkrankungen hat eine anhaltende, sehr hohe wissenschaftliche Relevanz. Ziel dabei ist es, möglichst selektiv nur das erkrankte Gewebe zu schädigen. Besonders relevant ist dabei die Adressierung von für das Zellüberleben wichtigen Strukturen, wie etwa der DNA. Erreicht werden kann dies zum Beispiel durch eine Sensitivierung der DNA gegenüber energiereicher Strahlung. Ein vielversprechender Ansatz ist dabei die Generierung von Auger-Elektronen, welche auf subzellulärer Reichweite eine hohe Energie abgeben (hoher Linear

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23

Punzet, Robert. "99mTc-HYNIC-DAPI-DNA-Bindungsnachweis und Nachweis von DNA-Doppelstrangbrüchen durch 99mTc-HYNIC-DAPI mittels Agarose-Gelelektrophorese." Doctoral thesis, 2013. https://tud.qucosa.de/id/qucosa%3A28141.

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Hintergrund: Ein sehr häufig in der nuklearmedizinischen Diagnostik genutztes Radionuklid ist 99mTc. Es emittiert Gammastrahlung mit einer relativ niedrigen Energie (140 keV) und hat eine kurze Halbwertszeit von 6 h. Zusätzlich zur Gammastrahlung entstehen bei jedem Zerfall von 99mTc Auger-Elektronen. Diese niederenergetischen Elektronen, sehr kurzer Reichweite verfügen über einen hohen LET und erzeugen somit eine ausreichende Energiedeposition, um direkte DSB zu erzeugen. Bei Untersuchungen zu Chemotoxizität und Radiotoxizität mit Zellexperimenten gilt es eine Vielzahl an verschiedenen Schut

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24

Pradeep, A. V. "Development of a Spin-Polarized Low Energy Electron Diffraction System and Investigation on Spin-Orbit and Exchange Interactions on Ir(100) and Ultrathin Fe(100) Grown on Ir(100)." Thesis, 2016. http://hdl.handle.net/2005/3202.

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Spin-polarized electron beam has not yet been produced from an unpolarized electron beam using Stern-Gerlach type spin filter, because of the Lorentz force and Heisenberg uncertainty principle. At present, electron spin detectors and filters work on the basis of spin-dependent scattering of an electron beam from crystal surfaces. Single channel efficiencies of all the spin detectors for electrons are orders of magnitudes lower than the ideal one. Specular reflection type spin-polarized low energy electron diffraction (SPLEED)-spin detectors are having higher single channel efficiencies compare

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25

Fernandez, Francisco. "Estructura del espectro de rayos x L de Cd y Sn." Bachelor's thesis, 2019. http://hdl.handle.net/11086/12695.

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Tesis (Lic. en Física)--Universidad Nacional de Córdoba, Facultad de Matemática, Astronomía, Física y Computación, 2019.<br>Fueron estudiadas las emisiones de rayos x provenientes de transiciones atómicas en las vacancias inducidas por impacto de electrones en la capa L del Cd y Sn. Para ello fue necesario realizar mediciones con un espectrómetro dispersivo en longitudes de onda, y el espectro obtenido fue procesado con un método de optimización de parámetros previamente desarrollado. Este procedimiento permitió determinar energı́as caracterı́sticas, probabilidades relativas de transición y an

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