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Journal articles on the topic 'Elementary Osmotic Pump'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Mr., Deo Abhijit J. Ms. Monika Ola Mrs. Rajveer Bhaskar Mr. Shinde Bhushan Dr.H.S. Mahajan. "REVIEW ON FORMULATION ASPECTS OF OSMOTIC DRUG DELIVERY SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 9172–82. https://doi.org/10.5281/zenodo.2682533.

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<em>The drug delivery System is a new approach to controlling the release of medicinal forms. A Wide range of drug delivery systems for patented osmosis resistance such as Rose-Nelson pump, Higuchi-leeper pump, higuchi-theeuwes pump, elementary osmotic pump etc. Possibility for poorly allowed medications, release of pulsatile drugs, zero emission order is useful. Different methods for sample ratio are obtained push pull osmotic Pump, osmotic Bursting osmotic pump, liquid oral osmotic system, sandwiched osmotic tablets (SOTS), long period of time delivery osmotic device, and controlled porosity

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2

Keraliya, Rajesh A., Chirag Patel, Pranav Patel, et al. "Osmotic Drug Delivery System as a Part of Modified Release Dosage Form." ISRN Pharmaceutics 2012 (July 17, 2012): 1–9. http://dx.doi.org/10.5402/2012/528079.

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Conventional drug delivery systems are known to provide an immediate release of drug, in which one can not control the release of the drug and can not maintain effective concentration at the target site for longer time. Controlled drug delivery systems offer spatial control over the drug release. Osmotic pumps are most promising systems for controlled drug delivery. These systems are used for both oral administration and implantation. Osmotic pumps consist of an inner core containing drug and osmogens, coated with a semipermeable membrane. As the core absorbs water, it expands in volume, which

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3

Ning, Meiying, Yue Zhou, Guojun Chen, and Xingguo Mei. "Preparation andIn Vitro/In VivoEvaluation of Vinpocetine Elementary Osmotic Pump System." Advances in Pharmacological Sciences 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/385469.

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Preparation andin vitroandin vivoevaluation of vinpocetine (VIN) elementary osmotic pump (EOP) formulations were investigated. A method for the preparation of VIN elementary osmotic pump tablet was obtained by adding organic acid additives to increase VIN solubility. VIN was used as the active pharmaceutical ingredient, lactose and mannitol as osmotic agent. Citric acid was used as increasing API solubility and without resulting in the API degradation. It is found that the VIN release rate was increasing with the citric acid amount at a constant range. Cellulose acetate 398-3 was employed as s

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4

Prasanna, N. *1 Srilatha Ch. 2. Subrahmanyam C. V. S.3. "Osmotic Controlled Release Oral Delivery System: An Overview." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 530–58. https://doi.org/10.5281/zenodo.10810393.

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Osmotic drug delivery systems (ODDS) are a type of controlled release technology that utilizes the principles of osmosis to deliver drugs in a precise and sustained manner. These systems typically consist of a core containing the drug and an osmotic agent, surrounded by a semipermeable membrane. Water from the surrounding environment draws in through the membrane due to the osmotic pressure generated by the core, pushing the drug solution out through a predefined delivery orifice in a controlled manner. Osmotic drug delivery devices, such as the Rose and Nelson pump, Higuchi Leeper pump, Higuc

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5

Patha, S., P. Dara, S. K. Yamsani, R. Thadkapally, and J. Aukunuru. "DEVELOPMENT AND EVALUATION OF ORAL ELEMENTARY OSMOTIC PUMP TABLETS FOR ROPINIROLE HYDROCHLORIDE." INDIAN DRUGS 49, no. 06 (2012): 23–30. http://dx.doi.org/10.53879/id.49.06.p0023.

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The objective of the present study was to develop a sustained release once a day oral elementary osmotic tablet for ropinirole hydrochloride and evaluate its in vivo performance. The core of elementary osmotic tablet of ropinirole hydrochloride was prepared by compression of mixture consisting of drug,different concentrations of osmogens, and other tablet material. Core tablets were then coated with different concentrations of cellulose acetate and PEG-400. FTIR was used to identify if the excipients are compatible with the drug. All the tablets that were prepared were evaluated for drug relea

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6

Ranga, Priya M., and Rajendran N N. "EXTENDED RELEASE OF NEVIRAPINE USING ELEMENTARY OSMOTIC PUMP TABLETS." Journal of Pharmaceutical & Scientific Innovation 4, no. 2 (2015): 127–33. http://dx.doi.org/10.7897/2277-4572.04229.

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7

Syed Shoaeb Mohammad, Syed Iftequar Ahmed, and Marathe RP. "Formulation development and evaluation of osmotic drug delivery system for lornoxicam." International Journal of Frontiers in Chemistry and Pharmacy Research 1, no. 1 (2022): 044–60. http://dx.doi.org/10.53294/ijfcpr.2021.1.1.0056.

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Osmotic systems are the most reliable controlled drug delivery systems and can be employed as oral drug delivery systems. Osmotic pressure is used as the driving force for these systems to release the drug in a controlled manner. Osmotic pump tablet (OPT) generally consists of a core including the drug(s), an osmotic agent, other excipients and semipermeable membrane coat. The aim of current study was to develop osmotic drug delivery system for Lornoxicam. Two different approaches were used for formulation, one was controlled porosity osmotic tablet and other was elementary osmotic tablet. The

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8

Fatima Shireen, M. Ajitha1, Roshan S. "Nateglinide Modified Release Dosage Form Using Elementary Osmotic Pump and Push Pull Osmotic Pump Methods: Formulation and in-vivo evaluation." Journal of Pharmaceutical Negative Results 13, no. 4 (2022): 1521–30. http://dx.doi.org/10.47750/pnr.2022.13.04.214.

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Objective: The aim was to develop osmotic tablets of nateglinide by two methods namely elementary osmotic pump (EOP) and push-pull osmotic pump (PPOP) method for controlled drug release. Methods: The tablets were prepared by the wet granulation and were evaluated for various physicochemical parameters, in-vitro dissolution and in-vitro dissolution. The optimised formulation obtained in both methods was further characterised for FTIR, stability studies and pharmacokinetic studies. Results: In EOP method coated tablet F14 showing highest drug release of 98.82%. In PPOP formulation FF

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9

Gong, Wei, Yan Liu, Dan-Yu Mei, Meiyan Yang, and Xing-Guo Mei. "Preparation, release and pharmacokinetics of a risperidone elementary osmotic pump system." Drug Development and Industrial Pharmacy 41, no. 3 (2014): 464–69. http://dx.doi.org/10.3109/03639045.2013.877923.

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10

Ouyang, Defang, Shufang Nie, Wei Li, Hong Guo, Hui Liu, and Weisan Pan. "Design and evaluation of compound metformin/glipizide elementary osmotic pump tablets." Journal of Pharmacy and Pharmacology 57, no. 7 (2005): 817–20. http://dx.doi.org/10.1211/0022357056370.

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11

Syed mujtaba pasha, Syed abid ali, Omair sohail ahmed, et al. "Osmotic drug delivery system of valsartan." International Journal of Research in Pharmaceutical Sciences and Technology 1, no. 2 (2019): 43–52. http://dx.doi.org/10.33974/ijrpst.v1i2.58.

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The objective of this study is to design and evaluate a new EOP called swellable elementary osmotic pump (SEOP) of the freely water soluble drug, amitriptyline hydrochloride (1 g /mL) by adding water swellable polymers in the core. The hydrophilic polymers included in the core retard the highly water soluble drug by producing hydrogel within the core, which may restrict and delay the solvent contact with drug molecules and may increase the diffusional length of the solvent to achieve a constant release rate. Thus, this technology can be exploited to achieve constant drug release at predetermin

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12

Bharadwaj, P., P. K. Upaddhyay, V. Agarwal, D. Chaurasia, H. Chaurasia, and R. Singh. "DEVELOPMENT AND CHARACTERIZATION OF ELEMENTARY OSMOTIC PUMP TABLETS FOR SIMULTANEOUS RELEASE OF METFORMIN AND GLIPIZIDE." INDIAN DRUGS 49, no. 11 (2012): 19–29. http://dx.doi.org/10.53879/id.49.11.p0019.

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The aim of present study was to design and evaluate an elementary osmotic pump-based drug delivery system for controlled release of metformin and glipizide simultaneously for treatment of type II noninsulin dependent diabetes mellitus. Inclusion complex of glipizide with β- cyclodextrin was prepared to enhance its solubility. Core tablets were prepared by wet granulation method. Effects of different variables like amount of plasticizer, osmogen, orifice size and dissolution media were studied on release profile for both drugs. Morphology of semi permeable was studied using electron microscope

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13

Patel, K. N., and T. A. Mehta. "Formulation Design and Characterization of an Elementary Osmotic Pump Tablet of Flurbiprofen." PDA Journal of Pharmaceutical Science and Technology 68, no. 4 (2014): 333–46. http://dx.doi.org/10.5731/pdajpst.2014.00984.

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14

Nokhodchi, Ali, Mohammed N. Momin, Javad Shokri, Mahbobeh Shahsavari, and Parinaz Ahmad Rashidi. "Factors Affecting the Release of Nifedipine from a Swellable Elementary Osmotic Pump." Drug Delivery 15, no. 1 (2008): 43–48. http://dx.doi.org/10.1080/10717540701829028.

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15

Pavani, J. "Formulation and Evaluation of Oral Elementary Osmotic Pump Tablets of Sumatriptan Succinate." British Journal of Pharmaceutical Research 4, no. 10 (2014): 1163–73. http://dx.doi.org/10.9734/bjpr/2014/8666.

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16

Kumar, Pramod, Sanjay Singh, and Brahmeshwar Mishra. "Development and Evaluation of Elementary Osmotic Pump of Highly Water Soluble Drug: Tramadol Hydrochloride." Current Drug Delivery 6, no. 1 (2009): 130–39. http://dx.doi.org/10.2174/156720109787048249.

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17

Salfi, Roshan, Fatima Shireen, and Makula Ajitha. "Optimization of Repaglinide Osmotic Drug Delivery System Using Two Different Techniques." International Journal of Pharmaceutical Sciences and Drug Research 14, no. 01 (2022): 29–36. http://dx.doi.org/10.25004/ijpsdr.2022.140104.

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The current study aimed to formulate an elementary osmotic pump (EOP) and push-pull osmotic pump (PPOP) based drug delivery system for controlled release of an anti-diabetic agent, repaglinide is expected to provide sustained release. EOP and PPOP method prepared repaglinide tablets by wet granulation technique. EOP designed 15 formulations F1-F15 and 14 formulations were done by PPOP method. All the formulations were evaluated for various physicochemical parameters and in-vitro dissolution studies. The release data was fitted into mathematical kinetic modeling studies to check the release mec

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18

Wang, Chao, Fei Chen, Paul Wan Sia Heng, et al. "A Novel Time-Controlled Release System Based on Drug–Resin Complexes and Elementary Osmotic Pump." CHEMICAL & PHARMACEUTICAL BULLETIN 56, no. 4 (2008): 457–63. http://dx.doi.org/10.1248/cpb.56.457.

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19

Shokri, Javad, Parinaz Ahmadi, Parisa Rashidi, Mahbobeh Shahsavari, Ali Rajabi-Siahboomi, and Ali Nokhodchi. "Swellable elementary osmotic pump (SEOP): An effective device for delivery of poorly water-soluble drugs." European Journal of Pharmaceutics and Biopharmaceutics 68, no. 2 (2008): 289–97. http://dx.doi.org/10.1016/j.ejpb.2007.06.006.

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20

Khan, Zulfequar Ahamad, Rahul Tripathi, and Brahmeshwar Mishra. "Floating Elementary Osmotic Pump Tablet (FEOPT) for Controlled Delivery of Diethylcarbamazine Citrate: a Water-Soluble Drug." AAPS PharmSciTech 12, no. 4 (2011): 1312–23. http://dx.doi.org/10.1208/s12249-011-9699-6.

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21

Monton, Chaowalit, and Poj Kulvanich. "Characterization of crosslinked hard gelatin capsules for a structural assembly of elementary osmotic pump delivery system." Journal of Pharmaceutical Investigation 49, no. 6 (2019): 655–65. http://dx.doi.org/10.1007/s40005-019-00426-2.

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22

S.K, Ghate Dr. D.M.Sakarkar. "DEVELOPMENT AND EVALUATION OF OSMOTICALLY CONTROLLED ORAL DRUG DELIVERY SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 459–70. https://doi.org/10.5281/zenodo.1036415.

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Conventional drug delivery systems have slight control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. They include dosage forms for oral and transdermal administration as well as injectable and implantable systems. For most of drugs, oral route remains as the most acceptable route of administration. Certain mole

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23

Alam, Naushad, Sarwar Beg, Mohammad Rizwan, et al. "Mucoadhesive elementary osmotic pump tablets of trimetazidine for controlled drug delivery and reduced variability in oral bioavailability." Drug Development and Industrial Pharmacy 41, no. 4 (2014): 692–702. http://dx.doi.org/10.3109/03639045.2014.900076.

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24

Zhang, Xuemei, Meng Wang, Pei Li, et al. "Application of hot-melt extrusion technology for designing an elementary osmotic pump system combined with solid dispersion for a novel poorly water-soluble antidepressant." Pharmaceutical Development and Technology 21, no. 8 (2015): 1006–14. http://dx.doi.org/10.3109/10837450.2015.1089896.

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25

Prabakaran, D. "Effect of hydrophilic polymers on the release of diltiazem hydrochloride from elementary osmotic pumps." International Journal of Pharmaceutics 259, no. 1-2 (2003): 173–79. http://dx.doi.org/10.1016/s0378-5173(03)00230-8.

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26

N, Preethi, and Sujatha S. "DEVELOPMENT AND EVALUATION OF SWELLABLE ELEMENTARY OSMOTIC PUMP TABLET OF GLIPIZIDE." International Journal of Pharmaceutical Sciences and Drug Research, October 1, 2013, 146–51. https://doi.org/10.25004/ijpsdr.2013.050403.

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A novel type of elementary osmotic pump [EOP] tablet for efficient delivery of poorly water-soluble drug, glipizide has been designed. Drug release from the system, called Swellable Elementary Osmotic Pump [SEOP], is through a delivery orifice in the form of a very fine dispersion, ready for dissolution and absorption. SEOP tablets were prepared by compressing the mixture of micronized drug and excipients into convex tablet. The effect of wetting agent, swelling agent, osmotic agent and hydrophobic plasticizer on the release rate were investigated. The release behavior of glipizide from differ

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27

CHOUDHARY, SRILATHA, CVS SUBRAHMANYAM, and K. PRIYANKA. "OSMOTIC DRUG DELIVERY SYSTEM OF NICORANDIL: DESIGN AND EVALUATION." International Journal of Applied Pharmaceutics, May 7, 2024, 119–28. http://dx.doi.org/10.22159/ijap.2024v16i3.50298.

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Objective: The purpose of the current research was to design a nicorandil formulation with controlled drug release using the principles of osmotic pump technology. Nicorandil is a biopharmaceutical classification system (BCS) class 3 drug, having a shorter plasma elimination half-life and bioavailability of 75 to 80%. Methods: The elementary osmotic pump (EOP) was prepared by coating a cellulose acetate polymer on the prepared core tablet. A 24-factorial design was applied to optimize the parameters for the osmotic tablet. A surface orifice was drilled. Results: Fourier transform infrared spec

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28

K Halakatti, Prabhu, Anita Desai, Sachin J Gaddimath, et al. "Development and Evaluation of Elementary Osmotic Pump Tablet of Tizanidine Hydrochloride." Rajiv Gandhi University of Health Sciences Journal of Pharmaceutical Sciences 12, no. 3 (2022). http://dx.doi.org/10.26463/rjps.12_3_5.

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Aim The objective of present research work was to develop a sustained release osmotic tablet of Tizanidine HCl using suitable osmogens.Methodology Tizanidine HCl containing elementary osmotic tablets were prepared using a wet granulation process. Initially dried granules were screened for various pre compression evaluation parameters. Further dried granules were punched using 8 mm die cavity in a tablet punching machine. Thus developed tablets were evaluated for post compression parameters like tablet hardness thickness weight variation friability dissolution studies stability studies and scan

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29

Quang Trung, Tran, Nguyen Thi Dao, Nguyen Thanh Hai, and Trinh Van Lau. "Preparation of Nifedipine Push-Pull Osmotic Pump Tablets." VNU Journal of Science: Medical and Pharmaceutical Sciences 36, no. 4 (2020). http://dx.doi.org/10.25073/2588-1132/vnumps.4284.

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This study aims to investigate the influence of the formulation factors on the drug release kinetics, thereby selecting the compositions of extended-release nifedipine tablet based on the similarity coefficient f2 obtained when compared with Adalat LA tablet. The formulation factors such as: molecular weight of the polyethylene oxide (PEO) and osmotic agent amount in drug layer and push layer, semi permeable membrane thickness (estimated by coating weight gain), orifice size, type of plasticizers and ratios of coating polymer to plasticizer in semipermeable membrane were evaluated. It was foun

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30

Fatima, Shire Fatima Shireen M. Ajitha Roshan. S*en M. Ajitha Roshan. S*. "DEVELOPMENT AND IN-VIVO EVALUATION OF REPAGLINIDE OSMOTIC DRUG DELIVERY SYSTEM USING TWO DIFFERENT TECHNIQUES." December 19, 2022. https://doi.org/10.5281/zenodo.7458465.

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<strong><em>Objective: </em></strong><em>The aim was to formulate elementary osmotic pump (EOP) and push-pull osmotic pump (PPOP) based drug delivery system for controlled release of an anti-diabetic agent, repaglinide.</em> <strong><em>Method: </em></strong><em>Repaglinide tablets were prepared by EOP and PPOP method by wet granulation technique. 15 formulations F1-F15 were designed by EOP and 14 formulations were done by PPOP method. All the formulations were evaluated for various physicochemical parameters and in-vitro dissolution studies. Further the optimised formulations from both the me

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31

S.K, Ghate Dr. D.M.Sakarkar. "DEVELOPMENT AND EVALUATION OF OSMOTICALLY CONTROLLED ORAL DRUG DELIVERY SYSTEM." September 30, 2017. https://doi.org/10.5281/zenodo.2526911.

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Conventional drug delivery systems have slight control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. They include dosage forms for oral and transdermal administration as well as injectable and implantable systems. For most of drugs, oral route remains as the most acceptable route of administration. Certain mole

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