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Journal articles on the topic 'Elf-expression'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Pishvaian, M. J., T. M. Blake, K. Kitisin, et al. "Haploinsufficiency of CDK4 prevents hepatocarcinogenesis in mice deficient in ELF, a mediator of TGF-beta signaling." Journal of Clinical Oncology 25, no. 18_suppl (2007): 10608. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.10608.

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10608 Background: The transforming growth factor-β (TGF-β) has a dual role in cancer, but in the prevention of tumorigenesis, TGF-β signaling inhibits cell cycle progression through an increase in cell cycle inhibitors and decrease in cell cycle activators. The adaptor protein embryonic liver fodrin (ELF) is crucial for normal TGF-β signaling. ELF facilitates the association and nuclear translocation of the TGF-β signaling proteins, Smad3 and Smad4. We have demonstrated that elf± mice develop hepatocellular cancers (HCC) spontaneously within 12 months. We have also shown that most human HCCs d

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Liu, Yong, Wen-bin Liu, Kai-jun Liu, et al. "Effect of 50 Hz Extremely Low-Frequency Electromagnetic Fields on the DNA Methylation and DNA Methyltransferases in Mouse Spermatocyte-Derived Cell Line GC-2." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/237183.

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Previous studies have shown that the male reproductive system is one of the most sensitive organs to electromagnetic radiation. However, the biological effects and molecular mechanism are largely unclear. Our study was designed to elucidate the epigenetic effects of 50 Hz ELF-EMFin vitro. Mouse spermatocyte-derived GC-2 cell line was exposed to 50 Hz ELF-EMF (5 min on and 10 min off) at magnetic field intensity of 1 mT, 2 mT, and 3 mT with an intermittent exposure for 72 h. We found that 50 Hz ELF-EMF exposure decreased genome-wide methylation at 1 mT, but global methylation was higher at 3 mT

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Huang, Xuling, Courtney Brown, Weihua Ni, Elizabeth Maynard, Alan C. Rigby, and Peter Oettgen. "Critical role for the Ets transcription factor ELF-1 in the development of tumor angiogenesis." Blood 107, no. 8 (2006): 3153–60. http://dx.doi.org/10.1182/blood-2005-08-3206.

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Abstract The Ets transcription factors regulate a wide variety of biologic processes. Several members have been shown to play a role in regulating angiogenesis and vascular development. For example, the Ets factor ELF-1 is enriched in the developing vasculature of the embryo, where it regulates the expression of the Tie2 gene. We have determined that ELF-1 and Tie2 expression is also enriched in tumor blood vessels, and have identified a short peptide, 34 amino acids in length, corresponding to the terminal portion of the highly conserved ETS domain that potently blocks the function of ELF-1.

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Cichon, Natalia, Ewelina Synowiec, Elzbieta Miller, et al. "Effect of Rehabilitation with Extremely Low Frequency Electromagnetic Field on Molecular Mechanism of Apoptosis in Post-Stroke Patients." Brain Sciences 10, no. 5 (2020): 266. http://dx.doi.org/10.3390/brainsci10050266.

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Apoptosis in acute stroke is associated with a negative prognosis and is correlated with the severity of the neurological deficit. However, there is no evidence that indicates that, in the subacute phase of the stroke, the apoptosis process might activate neuroplasticity. Therefore, in this study, we investigated the effect of an extremely low frequency electromagnetic field (ELF-EMF) on the molecular mechanism of apoptosis, as used in the rehabilitation of post-stroke patients. Patients with moderate stroke severity (n = 48), 3–4 weeks after incident, were enrolled in the analysis and divided

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Sajadian, Akram, Elham Razmpoosh, Farshid Alaeddini, and Maryam Bassiri. "1Hz and 100mT Electromagnetic Field Induces Apoptosis in Breast Cancer Cells Through Up-Regulation of P38 and P21." Multidisciplinary Cancer Investigation 4, no. 1 (2020): 23–29. http://dx.doi.org/10.30699/acadpub.mci.4.1.23.

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Introduction: Breast cancer is the most common cause of cancer-related death among women. Recently, extremely low-frequency electromagnetic field (ELF-EMF) has been proposed as a new interfering agent with future therapeutic potentials. Many studies have revealed that cellular processes such as apoptosis in breast cancer are affected by ELF-EMFs. However, more researches are needed to clarify the underlying mechanism of action for these fields. In this study, the apoptotic effect of ELF-EMF on the MC4L2 cell line was examined and the mRNA expression level of the P21 and P38 genes were further

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Shen, Qi, Haitao Zheng, Shao hua Chen, Lijian Yang, and Yangqiu Li. "The Change of Elf-1 Gene Expression Level in Hematological Malignancies." Blood 114, no. 22 (2009): 4704. http://dx.doi.org/10.1182/blood.v114.22.4704.4704.

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Abstract Abstract 4704 Elf-1 (E-74-like factor 1), a special transcription factor of T cells, is a member of the Ets (E-26-specific) family. Elf-1 plays a critical role in the transcription of the TCR ζ-chain. Our previous studies showed that the low expression level of TCR ζ-chain in hematologic malignancies, in the present study, we farther analyzed the expression of Elf-1 in patients with hematologic malignancies. Real-time PCR with SYBR Green I technique was used for detecting Elf-1 expression level in peripheral blood mononuclear cells from 33 patients with acute myeloid leukemia (AML) [i

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Albl-Mikasa, Michaela. "ELF speakers’ restricted power of expression." Describing Cognitive Processes in Translation: Acts and events 8, no. 2 (2013): 191–210. http://dx.doi.org/10.1075/tis.8.2.04alb.

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At the crossroads of English as a lingua franca (ELF) research and interpreting studies, it is paramount to examine why interpreters are at odds with ELF communication in general and with the effects of the output of the growing number of non-native English conference speakers on their work in particular. On the basis of a small-scale case study, the stumbling blocks resulting from non-native English input are examined. The findings point toward what may be a major impediment: activation and retrieval constraints can result from ELF speakers’ restricted power of expression and have an adverse

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8

Morabito, Caterina, Nathalie Steimberg, Francesca Rovetta, et al. "Extremely Low-Frequency Electromagnetic Fields Affect Myogenic Processes in C2C12 Myoblasts: Role of Gap-Junction-Mediated Intercellular Communication." BioMed Research International 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/2460215.

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Extremely low-frequency electromagnetic fields (ELF-EMFs) can interact with biological systems. Although they are successfully used as therapeutic agents in physiatrics and rehabilitative practice, they might represent environmental pollutants and pose a risk to human health. Due to the lack of evidence of their mechanism of action, the effects of ELF-EMFs on differentiation processes in skeletal muscle were investigated. C2C12 myoblasts were exposed to ELF-EMFs generated by a solenoid. The effects of ELF-EMFs on cell viability and on growth and differentiation rates were studied using colorim

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Choi, Ju-Hye, Yu-Mi Kim, Hee-Jung Park, Myeong-Hyun Nam та Young-Kwon Seo. "Extremely Low-Frequency Electromagnetic Fields Increase Cytokines in Human Hair Follicles through Wnt/β-Catenin Signaling". Biomedicines 10, № 4 (2022): 924. http://dx.doi.org/10.3390/biomedicines10040924.

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Hair loss is a chronic disorder that affects many people; however, a complete treatment has not yet been developed. Therefore, new therapeutic agents for preventing hair loss must be developed, and electromagnetic field (EMF) therapy has been proven to be a promising medical treatment in various fields, including hair loss treatment. This study evaluated the effect of extremely low-frequency electromagnetic field (ELF-EMF) intensity and exposure time by analyzing the expression of cytokines and anagen-related molecules, which influence hair activation and growth, in hair bulb spheroid (HBS) an

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Lim, KiTaek, Jin Hexiu, Jangho Kim, et al. "Effects of Electromagnetic Fields on Osteogenesis of Human Alveolar Bone-Derived Mesenchymal Stem Cells." BioMed Research International 2013 (2013): 1–14. http://dx.doi.org/10.1155/2013/296019.

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This study was performed to investigate the effects of extremely low frequency pulsed electromagnetic fields (ELF-PEMFs) on the proliferation and differentiation of human alveolar bone-derived mesenchymal stem cells (hABMSCs). Osteogenesis is a complex series of events involving the differentiation of mesenchymal stem cells to generate new bone. In this study, we examined not merely the effect of ELF-PEMFs on cell proliferation, alkaline phosphatase (ALP) activity, and mineralization of the extracellular matrix but vinculin, vimentin, and calmodulin (CaM) expressions in hABMSCs during osteogen

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Tupitsyn I. I., Kaygorodov M. Y., Glazov D. A., Ryzhkov A. M., Usov D. P., and Shabaev V. M. "Application of the Relativistic Electron Localization Function to Study the Electronic Structure of Superheavy Elements." Optics and Spectroscopy 130, no. 7 (2022): 824. http://dx.doi.org/10.21883/eos.2022.07.54722.3459-22.

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A formula for calculating the relativistic electron localization function (RELF) within the framework of the Dirac-Fock method is obtained. An approach similar to that used earlier in [A.D. Becke and K.E. Edgecombe, The Journal of Chemical Physics 92, 5397 (1990)] in deriving an expression for the nonrelativistic electron localization function (ELF) is applied. It is demonstrated that the expression for RELF differs from the expression for ELF with replacement of the nonrelativistic electron density by its relativistic counterpart. Relativistic calculations of ELF and RELF for a number of supe

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Rellahan, Barbara L., Jane P. Jensen, Thomas K. Howcroft, Dinah S. Singer, Ezio Bonvini та Allan M. Weissman. "Elf-1 Regulates Basal Expression from the T Cell Antigen Receptor ζ-Chain Gene Promoter". Journal of Immunology 160, № 6 (1998): 2794–801. http://dx.doi.org/10.4049/jimmunol.160.6.2794.

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Abstract In mature T cells, limited synthesis of the TCR-ζ subunit is primarily responsible for regulating surface expression of TCRs. Transcription of ζ is directed by a complex promoter that includes two potential binding sites for the Ets family of transcription factors at −52 (zEBS1) and −135 (zEBS2). Mutation of these two sites results in a marked reduction of transcription from this promoter. Using electrophoretic mobility shift analysis, Elf-1 was demonstrated to be the Ets family member that binds to these sites. One site, zEBS1, matches the optimal Elf-1 consensus sequence in eight of

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Morabito, Caterina, Noemi Di Sinno, Maria A. Mariggiò, and Simone Guarnieri. "Impact of Extremely Low-Frequency Electromagnetic Fields on Skeletal Muscle of Sedentary Adult Mice: A Pilot Study." International Journal of Molecular Sciences 25, no. 18 (2024): 9857. http://dx.doi.org/10.3390/ijms25189857.

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Extremely low-frequency electromagnetic fields (ELF-EMFs) are ubiquitous in industrialized environments due to the continuous use of electrical devices. Our previous studies demonstrated that ELF-EMFs affect muscle cells by modulating oxidative stress and enhancing myogenesis. This pilot study investigated these effects on the skeletal muscles of sedentary adult mice, assessing physiological responses to ELF-EMF exposure and potential modulation by antioxidant supplementation. Male C57BL/6 mice were exposed to ELF-EMFs (0.1 or 1.0 mT) for 1 h/day for up to 5 weeks and fed a standard diet witho

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Isaković, Jasmina, Filip Slatković, Denis Jagečić, Dražen Juraj Petrović, and Dinko Mitrečić. "Pulsating Extremely Low-Frequency Electromagnetic Fields Influence Differentiation of Mouse Neural Stem Cells towards Astrocyte-like Phenotypes: In Vitro Pilot Study." International Journal of Molecular Sciences 25, no. 7 (2024): 4038. http://dx.doi.org/10.3390/ijms25074038.

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Even though electromagnetic fields have been reported to assist endogenous neurogenesis, little is known about the exact mechanisms of their action. In this pilot study, we investigated the effects of pulsating extremely low-frequency electromagnetic fields on neural stem cell differentiation towards specific phenotypes, such as neurons and astrocytes. Neural stem cells isolated from the telencephalic wall of B6(Cg)-Tyrc-2J/J mouse embryos (E14.5) were randomly divided into three experimental groups and three controls. Electromagnetic field application setup included a solenoid placed within a

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Cichoń, Natalia, Piotr Czarny, Michał Bijak, et al. "Benign Effect of Extremely Low-Frequency Electromagnetic Field on Brain Plasticity Assessed by Nitric Oxide Metabolism during Poststroke Rehabilitation." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/2181942.

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Nitric oxide (NO) is one of the most important signal molecules, involved in both physiological and pathological processes. As a neurotransmitter in the central nervous system, NO regulates cerebral blood flow, neurogenesis, and synaptic plasticity. The aim of our study was to investigate the effect of the extremely low-frequency electromagnetic field (ELF-EMF) on generation and metabolism of NO, as a neurotransmitter, in the rehabilitation of poststroke patients. Forty-eight patients were divided into two groups: ELF-EMF and non-ELF-EMF. Both groups underwent the same 4-week rehabilitation pr

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Ki, Ga-Eun, Yu-Mi Kim, Han-Moi Lim, Eun-Cheol Lee, Yun-Kyong Choi та Young-Kwon Seo. "Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway". International Journal of Molecular Sciences 21, № 3 (2020): 784. http://dx.doi.org/10.3390/ijms21030784.

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Despite advances in medical treatments, the proportion of the population suffering from alopecia is increasing, thereby creating a need for new treatments to control hair loss and prevent balding. Human hair follicle dermal papilla cells (hDPCs), a type of specialized fibroblast in the hair bulb, play an essential role in controlling hair growth and in conditions like androgenic alopecia. This study aimed to evaluate the intensity-dependent effect of extremely low-frequency electromagnetic fields (ELF-EMFs) on the expression of anagen-related molecules in hDPCs in vitro. We examined the effect

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Patruno, Antonia, Erica Costantini, Alessio Ferrone, et al. "Short ELF-EMF Exposure Targets SIRT1/Nrf2/HO-1 Signaling in THP-1 Cells." International Journal of Molecular Sciences 21, no. 19 (2020): 7284. http://dx.doi.org/10.3390/ijms21197284.

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Extremely low frequency electromagnetic fields (ELF-EMFs) have been known to modulate inflammatory responses by targeting signal transduction pathways and influencing cellular redox balance through the generation of oxidants and antioxidants. Here, we studied the molecular mechanism underlying the anti-oxidative effect of ELF-EMF in THP-1 cells, particularly with respect to antioxidant enzymes, such as heme oxygenase-1 (HO-1), regulated transcriptionally through nuclear factor E2-related factor 2 (Nrf2) activation. Cells treated with lipopolysaccharides (LPS) were exposed to a 50 Hz, 1 mT extr

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Chen, Yangmengfan, Benedikt J. Braun, Maximilian M. Menger, et al. "Intermittent Exposure to a 16 Hz Extremely Low Frequency Pulsed Electromagnetic Field Promotes Osteogenesis In Vitro through Activating Piezo 1-Induced Ca2+ Influx in Osteoprogenitor Cells." Journal of Functional Biomaterials 14, no. 3 (2023): 165. http://dx.doi.org/10.3390/jfb14030165.

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Exposure to extremely low frequency pulsed electromagnetic fields (ELF-PEMF) is supposed to simulate local EMF generated during mechanical stimulation of bone and may therefore be used to improve bone regeneration. This study aimed at optimizing the exposure strategy and investigating the underlying mechanisms of a 16 Hz ELF-PEMF, previously reported to boost osteoblast function. Comparing influences of daily continuous (30 min every 24 h) and intermittent (10 min every 8 h) exposure to the 16 Hz ELF-PEMF on osteoprogenitor cells revealed that the intermittent exposure strategy enhanced the 16

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Liu, Chao, Bing Wang, Hong Qiang Xu, and Yun Long Liu. "The Impedance Characteristics of ELF Line-Current Antenna over Inhomogeneous Anisotropic Ground." Applied Mechanics and Materials 548-549 (April 2014): 771–75. http://dx.doi.org/10.4028/www.scientific.net/amm.548-549.771.

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The impedance of a horizontal Extremely low frequency (ELF) line-current antenna is studied. A new analytic expression for calculating a grounding resistance in any shape of ground screen in a two-layer earth is proposed, model adapted to a bed-rock with high resistivity. Its calculated accuracy has a significant improvement compared with previous literature. The radiation resistance of an ELF line-current antenna over inhomogeneous anisotropic ground is researched. The effect of anisotropy of the ground conductivity on radiation efficiency of an ELF line-current antenna is analyzed. The obtai

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Choi, Hak-Jong, Yanbiao Geng, Hoonsik Cho, et al. "Differential requirements for the Ets transcription factor Elf-1 in the development of NKT cells and NK cells." Blood 117, no. 6 (2011): 1880–87. http://dx.doi.org/10.1182/blood-2010-09-309468.

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Abstract E26 Transformation specific (Ets) family transcription factors control the expression of a large number of genes regulating hematopoietic cell development and function. Two such transcription factors, Ets-1 and myeloid Elf-1–like factor (MEF), have been shown to play critical roles in both natural killer (NK)– and NKT-cell development, but not in the development of conventional T cells. In this study, we address the role of E74-like factor 1 (Elf-1), another Ets family transcription factor that is closely related to MEF but divergent from Ets-1, in NK- and NKT-cell development using E

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Lv, Ye, Shuchang Chen, Bing Zhu, et al. "Exposure to 50 Hz Extremely-Low-Frequency Magnetic Fields Induces No DNA Damage in Cells by Gamma H2AX Technology." BioMed Research International 2021 (February 15, 2021): 1–11. http://dx.doi.org/10.1155/2021/8510315.

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The current results for extremely-low-frequency magnetic fields (ELF-MF) on DNA damage are still debated. A sensitive indicator and systematic research are needed to assess the effects of ELF-MF. In this study, we used γH2AX as an early and sensitive molecular marker to evaluate the DNA damage effects of ELF-MF in vitro. Human amnion epithelial cells (FLs), human skin fibroblast cells (HSFs), and human umbilical vein endothelial cells (HUVECs) were exposed to 50 Hz ELF-MF at 0.4, 1, and 2 mT for 15 min, 1 h, and 24 h, respectively. After exposure, cells were subjected to γH2AX immunofluorescen

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John, S., R. B. Reeves, J. X. Lin, et al. "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins." Molecular and Cellular Biology 15, no. 3 (1995): 1786–96. http://dx.doi.org/10.1128/mcb.15.3.1786.

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The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is rapidly and potently induced in T cells in response to mitogenic stimuli. Previously, an inducible enhancer between nucleotides -299 and -228 that contains NF-kappa B and CArG motifs was identified. We now report the characterization of a second essential positive regulatory element located between nucleotides -137 and -64 that binds Elf-1 and HMG-I(Y). This element had maximal activity in lymphoid cells, paralleling the cell type specificity of Elf-1 expression. Transcription from the IL-2R alpha promoter was inhibited when either t

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Bergemann, A. D., H. J. Cheng, R. Brambilla, R. Klein, and J. G. Flanagan. "ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites." Molecular and Cellular Biology 15, no. 9 (1995): 4921–29. http://dx.doi.org/10.1128/mcb.15.9.4921.

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The Eph receptors are the largest known family of receptor tyrosine kinases and are notable for distinctive expression patterns in the nervous system and in early vertebrate development. However, all were identified as orphan receptors, and only recently have there been descriptions of a corresponding family of ligands. We describe here a new member of the Eph ligand family, designated ELF-2 (Eph ligand family 2). The cDNA sequence for mouse ELF-2 indicates that it is a transmembrane ligand. It shows closest homology to the other known transmembrane ligand in the family, ELK-L/LERK-2/Cek5-L, w

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Ichikawa, T., K. Matsunaga, Y. Minakata, et al. "Possible Impact of Salivary Influence on Cytokine Analysis in Exhaled Breath Condensate." Analytical Chemistry Insights 2 (January 2007): 117739010700200. http://dx.doi.org/10.4137/117739010700200007.

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Background Exhaled breath condensate (EBC) is thought to contain substances of the lower airway epithelial lining fluid (ELF) aerosolized by turbulent flow. However, contamination by saliva may affect the EBC when collected orally. Objective The purpose of this study was to compare the cytokine expression levels in EBC with those in saliva, and to clarify the influence of saliva on cytokine measurements of EBC. Methods EBC and saliva samples were obtained from 10 adult subjects with stable asthma. To estimate differences in the contents of substances between EBC and saliva, the total protein c

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Gottschalk, L. R., D. M. Giannola, and S. G. Emerson. "Molecular regulation of the human IL-3 gene: inducible T cell-restricted expression requires intact AP-1 and Elf-1 nuclear protein binding sites." Journal of Experimental Medicine 178, no. 5 (1993): 1681–92. http://dx.doi.org/10.1084/jem.178.5.1681.

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Interleukin 3 (IL-3) is a hematopoietic stem-cell growth and differentiation factor that is expressed solely in activated T and NK cells. Studies to date have identified elements 5' to the IL-3 coding sequences that regulate its transcription, but the sequences that confer T cell-specific expression remain to be clearly defined. We have now identified DNA sequences that are required for T cell-restricted IL-3 gene transcription. A series of transient transfections performed with human IL-3-chloramphenicol acetyltransferase (CAT) reporter plasmids in T and non-T cells revealed that a plasmid co

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Potenza, Lucia, Roberta Saltarelli, Emanuela Polidori, et al. "Effect of 300 mT static and 50 Hz 0.1 mT extremely low frequency magnetic fields on Tuber borchii mycelium." Canadian Journal of Microbiology 58, no. 10 (2012): 1174–82. http://dx.doi.org/10.1139/w2012-093.

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The present work aimed to investigate whether exposure to static magnetic field (SMF) and extremely low frequency magnetic field (ELF-MF) can induce biomolecular changes on Tuber borchii hyphal growth. Tuber borchii mycelium was exposed for 1 h for 3 consecutive days to a SMF of 300 mT or an ELF-MF of 0.1 mT 50 Hz. Gene expression and biochemical analyses were performed. In mycelia exposed to ELF-MF, some genes involved in hyphal growth, investigated using quantitative real-time polymerase chain reaction, were upregulated, and the activity of many glycolytic enzymes was increased. On the contr

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Lee, S. M., P. S. Danielian, B. Fritzsch, and A. P. McMahon. "Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain." Development 124, no. 5 (1997): 959–69. http://dx.doi.org/10.1242/dev.124.5.959.

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The developing vertebrate mesencephalon shows a rostrocaudal gradient in the expression of a number of molecular markers and in the cytoarchitectonic differentiation of the tectum, where cells cease proliferating and differentiate in a rostral to caudal progression. Tissue grafting experiments have implicated cell signalling by the mesencephalic-metencephalic (mid-hindbrain) junction (or isthmus) in orchestrating these events. We have explored the role of Wnt-1 and FGF8 signalling in the regulation of mesencephalic polarity. Wnt-1 is expressed in the caudal mesencephalon and Fgf8 in the most r

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Zarrin, Farzaneh, Seyed Mohammad Mahdavi, Amir Modarresi Chahardehi, Zahra Razzaghi, and Nayebali Ahmadi. "The Effect of Time-Dependence of 10 Hz Electromagnetic Field on Spatial Learning and Memory in Rats." Journal of Lasers in Medical Sciences 13 (December 12, 2022): e64. http://dx.doi.org/10.34172/jlms.2022.64.

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Introduction: In everyday life, electrical devices are the primary sources of extremely low-frequency electromagnetic fields (ELF-EMF), and the human body may be a great conductor of these fields. We chose alpha band power, especially at 10 Hz frequency, due to its prior beneficial role in memory. The purpose was to clarify whether there is a relationship between ELF-EMF exposure and cognitive deficits in rats, clinical signs, behavioral analysis, and the impact of ELF-EMF during different times of exposure on neuroplasticity via the expression of BDNF. Methods: Forty adult male rats were sele

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Kumazoe, Motofumi, Mai Yamashita, Yuki Nakamura, et al. "Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression." Journal of Immunology 199, no. 9 (2017): 3261–69. http://dx.doi.org/10.4049/jimmunol.1601822.

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Fukuda, Naoya, Tomohiro Suenaga, Erika Miura, Atsuko Tsukamoto, and Jorunn E. Olsen. "The Expression of ELF4-Like Genes Is Influenced by Light Quality in Petunia." Agronomy 10, no. 11 (2020): 1800. http://dx.doi.org/10.3390/agronomy10111800.

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The signals from photoreceptors modify plant morphogenesis and regulate the timing of flowering. In the long-day plant petunia, flowering is accelerated under blue (B) and white (W) light compared to red (R) light. In Arabidopsis thaliana L., ELF genes are involved in circadian clock-associated regulation of flowering under different light conditions. In this study, we aimed to assess the involvement of ELF genes in control of flowering by light quality in petunia. Two ELF4-like genes, PhELF4-1 and PhELF4-2 with 76% and 70% similarity to orthologues in pepper but low overall similarity to ELF

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Mahmoudinasab, Hamideh, and Mostafa Saadat. "Short-term Exposure to 50-Hz Electromagnetic Field and Alterations in NQO1 and NQO2 Expression in MCF-7 Cells." Open Access Macedonian Journal of Medical Sciences 4, no. 4 (2016): 548–50. http://dx.doi.org/10.3889/oamjms.2016.102.

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AIM: Extremely low-frequency electromagnetic fields (ELF-EMFs) have some genotoxic effects and it may alter the mRNA levels of antioxidant genes. The NAD(P)H: quinone oxidoreductase-1 (NQO1) and NQO2 are ubiquitously expressed. Considering that there is no published data on the effect(s) of ELF-EMF (50-Hz) exposure and expression levels of NQO1 and NQO2 in the human MCF-7 cells, the present study was carried out.METHODS: The ELF-EMF (0.25 and 0.50 mT) exposure patterns were: 5 min field-on/5 min filed-off, 15 min field-on/15 min field-off, and 30 min field-on continuously. In all exposure cond

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Davis, J. Nathan, and Martine F. Roussel. "Cloning and expression of the murine Elf-1 cDNA." Gene 171, no. 2 (1996): 265–69. http://dx.doi.org/10.1016/0378-1119(96)00013-3.

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Toomaneejinda, Anuchit, and Luke Harding. "Disagreement practices in ELF academic group discussion: verbal, nonverbal and interactional strategies." Journal of English as a Lingua Franca 7, no. 2 (2018): 307–32. http://dx.doi.org/10.1515/jelf-2018-0016.

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Abstract Academic group work can involve challenging pragmatic acts, and chief among these is, arguably, disagreement. There is little known, however, about how disagreement is realised in ELF academic group discussion tasks, where the tendency towards greater cooperation and mutual support in ELF communication may be at odds with the need to achieve task goals through the expression of an oppositional stance. In addressing this issue, the current study sought to answer the research question: how do postgraduate students in a UK university setting express their disagreement in ELF academic gro

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Pooam, Marootpong, Maresuke Nakayama, Chihiro Nishigaki, and Hidetake Miyata. "Effect of 50-Hz Sinusoidal Magnetic Field on the Production of Superoxide Anion and the Expression of Heat-shock Protein 70 in RAW264 Cells." International Journal of Chemistry 9, no. 2 (2017): 23. http://dx.doi.org/10.5539/ijc.v9n2p23.

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There is a growing concern if the power-line frequency (50/60 Hz) magnetic field (termed in this paper ELF-MF) increases cancer risks. Since one of the major causes of cancer is cellular oxidative stress, whether the ELF-MF increases the oxidative stress is a central problem in the studies on the biological effect of the ELF-MF. Here, we have investigated the effect of 50-Hz sinusoidal magnetic field on the production of O2-, the expression of heat shock protein (HSP) 70 and the mitochondrial membrane potential in cell line macrophage RAW264 cells. Macrophages were exposed to or not exposed to

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Kumazoe, Motofumi, Mai Yamashita, Yuki Nakamura, et al. "Correction: Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression." Journal of Immunology 200, no. 7 (2018): 2502–4. http://dx.doi.org/10.4049/jimmunol.1800143.

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Bracci, Massimo, Raffaella Lazzarini, Francesco Piva, et al. "Proteomic Characterization of Human Peripheral Blood Mononuclear Cells Exposed to a 50 Hz Magnetic Field." International Journal of Molecular Sciences 26, no. 13 (2025): 6035. https://doi.org/10.3390/ijms26136035.

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Exposure to extremely low-frequency magnetic fields (ELF-MF) can induce biological alterations in human cells, including peripheral blood mononuclear cells (PBMCs). However, the molecular mechanisms and key regulatory factors underlying this cellular response remain largely unknown. In this study, we analyzed the proteomic profiles of PBMCs isolated from three human subjects. PBMCs were exposed to 50 Hz, 1 mT of ELF-MF for 24 h and compared to unexposed PBMCs from the same individuals. ELF-MF exposure altered the expression levels of several PBMC proteins without affecting cell proliferation,

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Voo, Kui Shin, and David G. Skalnik. "Elf-1 and PU.1 Induce Expression of gp91phox Via a Promoter Element Mutated in a Subset of Chronic Granulomatous Disease Patients." Blood 93, no. 10 (1999): 3512–20. http://dx.doi.org/10.1182/blood.v93.10.3512.410k19_3512_3520.

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The cytochrome b heavy chain (gp91phox) is the redox center of the NADPH-oxidase and is highly expressed in mature myeloid cells. Point mutations at −57, −55, −53, and −52 bp of the gp91phox promoter have been detected in patients with chronic granulomatous disease (CGD; Newburger et al,J Clin Invest 94:1205, 1994; and Suzuki et al, Proc Natl Acad Sci USA 95:6085, 1998). We report that Elf-1 and PU.1,ets family members highly expressed in myeloid cells, bind to this promoter element. Either factor trans-activates the −102 to +12 bp gp91phox promoter when overexpressed in nonhematopoietic HeLa

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Panjali, Zahra, Omar Hahad, Fatemeh Rajabi, Saeid Maddah, and Rezvan Zendehdel. "Occupational exposure to metal-rich particulate matter modifies the expression of repair genes in foundry workers." Toxicology and Industrial Health 37, no. 8 (2021): 504–12. http://dx.doi.org/10.1177/07482337211021202.

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Foundry workers are exposed to numerous occupational health hazards, which may result in increased risk of cancer, respiratory disease, and other diseases. Oxidative stress is known to be involved in the pathogenesis of such diseases. The present study aimed to investigate the association between multiple occupational exposures in foundry workers and expression of deoxyribonucleic acid (DNA) repair genes as a biomarker of oxidative DNA damage. The study sample comprised 17 foundry workers and 27 matched control subjects. Expression of 8-oxoguanine DNA glycosylase-1 (OGG1), inosine triphosphate

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John, S., R. Marais, R. Child, Y. Light, and W. J. Leonard. "Importance of low affinity Elf-1 sites in the regulation of lymphoid-specific inducible gene expression." Journal of Experimental Medicine 183, no. 3 (1996): 743–50. http://dx.doi.org/10.1084/jem.183.3.743.

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Elf-1 is an Ets family transcription factor that regulates a number of inducible lymphoid-specific genes, including those encoding interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), and the IL-2 receptor (IL-2R) alpha chain. A minimal oligonucleotide spanning the IL-2R alpha Elf-1 site (-97/-84) bound Elf-1 poorly, but binding activity markedly increased when this oligonucleotide was multimerized or flanking sequences were added. This result is consistent with the requirement of accessory proteins for efficient Elf-1 binding, as has been demonstrated for the GM-CS

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Bassuk, Alexander G., Kevin P. Barton, Roshani T. Anandappa, Min M. Lu, and Jeffrey M. Leiden. "Expression Pattern of the Ets-related Transcription Factor Elf-1." Molecular Medicine 4, no. 6 (1998): 392–401. http://dx.doi.org/10.1007/bf03401746.

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Van Klaveren, R. J., D. Dinsdale, J. L. Pype, M. Demedts, and B. Nemery. "Changes in gamma-glutamyltransferase activity in rat lung tissue, BAL, and type II cells after hyperoxia." American Journal of Physiology-Lung Cellular and Molecular Physiology 273, no. 3 (1997): L537—L547. http://dx.doi.org/10.1152/ajplung.1997.273.3.l537.

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The effect of hyperoxia on gamma-glutamyltransferase (gamma-GT), an important enzyme for the uptake of precursor molecules for intracellular synthesis of glutathione (GSH), has not been established. Our aim was to investigate the effects of prolonged subtoxic levels of hyperoxia on gamma-GT activity and GSH levels in lung tissue, epithelial lining fluid (ELF), and isolated rat type II cells immediately after their isolation and 48 h later when kept in culture in normoxia. Seventeen male Wistar rats were divided in three groups (n = 5-7) and were exposed to air or to 60 or 85% O2 for 7 days. Pu

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Mouthon, MA, M. Freund, M. Titeux, et al. "Growth and differentiation of the human megakaryoblastic cell line (ELF- 153): a model for early stages of megakaryocytopoiesis." Blood 84, no. 4 (1994): 1085–97. http://dx.doi.org/10.1182/blood.v84.4.1085.1085.

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Abstract ELF-153 is a cell line that has been established from a patient with a poorly differentiated acute myeloid leukemia associated with an acute myelofibrosis. A majority of cells had a blast morphology with the phenotype of a myeloid hematopoietic progenitor, ie, CD34+, CD33+, CD13+, HLA-DR+, but CD38-, and the remaining cells (5% to 10%) expressed platelet restricted proteins such as CD41, CD42, CD36, CD61, and von Willebrand factor; some of them were polyploid (up to 32N) and exhibited demarcation membranes and alpha granules. No erythroid or other lineage-specific markers were detecte

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Mouthon, MA, M. Freund, M. Titeux, et al. "Growth and differentiation of the human megakaryoblastic cell line (ELF- 153): a model for early stages of megakaryocytopoiesis." Blood 84, no. 4 (1994): 1085–97. http://dx.doi.org/10.1182/blood.v84.4.1085.bloodjournal8441085.

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ELF-153 is a cell line that has been established from a patient with a poorly differentiated acute myeloid leukemia associated with an acute myelofibrosis. A majority of cells had a blast morphology with the phenotype of a myeloid hematopoietic progenitor, ie, CD34+, CD33+, CD13+, HLA-DR+, but CD38-, and the remaining cells (5% to 10%) expressed platelet restricted proteins such as CD41, CD42, CD36, CD61, and von Willebrand factor; some of them were polyploid (up to 32N) and exhibited demarcation membranes and alpha granules. No erythroid or other lineage-specific markers were detected. Prolif

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Salakhyan, Elena. "Signalling the loopholes and spreading the trampoline: a relevance-theoretic perspective on ELF communication." Journal of English as a Lingua Franca 13, no. 2 (2024): 261–83. https://doi.org/10.1515/jelf-2025-2003.

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Abstract The paper examines English as a Lingua Franca (ELF) communication from a relevance-theoretic perspective. Communication in English as a Lingua Franca is a type of interaction in which multilingual speakers use a variety of linguistic and non-linguistic means to achieve mutual intelligibility and maximum communicative effectiveness. The interaction of the ad hoc and dynamic conditions results in the development of properties that become typical for communicative encounters, where successful communication and mutual intelligibility are the goals. ELF interaction is thus characterized by

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Rusterholz, Corinne, Patricia Corthésy Henrioud та Markus Nabholz. "Interleukin-2 (IL-2) Regulates the Accessibility of the IL-2-Responsive Enhancer in the IL-2 Receptor α Gene to Transcription Factors". Molecular and Cellular Biology 19, № 4 (1999): 2681–89. http://dx.doi.org/10.1128/mcb.19.4.2681.

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ABSTRACT Interleukin-2 (IL-2) responsiveness of T lymphocytes is controlled through transcription of the IL-2 receptor (IL-2R) α subunit by antigen and by IL-2 itself. IL-2 induces IL-2Rα transcription via an IL-2-responsive enhancer (IL-2rE), whose activity depends on the cooperative binding of IL-2-induced STAT5 to two sites and of constitutively active Elf-1 to a third one. Here we describe the changes in IL-2rE chromatin that occur in normal T lymphocytes upon activation of IL-2Rα expression. In cells induced to transiently express IL-2Rα with concanavalin A (which mimics antigen), none of

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Heydemann, A., G. Juang, K. Hennessy, M. S. Parmacek, and M. C. Simon. "The myeloid-cell-specific c-fes promoter is regulated by Sp1, PU.1, and a novel transcription factor." Molecular and Cellular Biology 16, no. 4 (1996): 1676–86. http://dx.doi.org/10.1128/mcb.16.4.1676.

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The protein product of the c-fps/fes (c-fes) proto-oncogene has been implicated in the normal development of myeloid cells (macrophages and neutrophils). mRNA for c-fes has been detected exclusively in myeloid cells and vascular endothelial cells in adult mammals. Although a 13-kilobase-pair (kb) human c-fes transgene exhibits high levels of expression in mice, the sequences that confer myeloid-cell-specific expression of the human c-fes gene have not been defined. Transient-transfection experiments demonstrated that plasmids containing 446 bp of c-fes 5'-flanking sequences linked to a lucifer

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Provenzano, Alfredo Errico, Stefano Amatori, Maria Gemma Nasoni, et al. "Effects of Fifty-Hertz Electromagnetic Fields on Granulocytic Differentiation of ATRA-Treated Acute Promyelocytic Leukemia NB4 Cells." Cellular Physiology and Biochemistry 46, no. 1 (2018): 389–400. http://dx.doi.org/10.1159/000488473.

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Background/Aims: Life on Earth is constantly exposed to electromagnetic fields (EMFs) and the effects induced by EMFs on biological systems have been extensively studied producing different and sometimes contradictory results. Extremely low-frequency electromagnetic fields (ELF-EMFs) have shown to play a role in regulating cell proliferation and differentiation, although how EMFs influence these processes remains unclear. Human acute promyelocytic leukemia (APL) cells are characterized by the arrest of differentiation at the promyelocytic stage due to epigenetic perturbations induced by PML/RA

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Hernández-Pavón, Julio César, Modesto Sosa, Teodoro Córdova, Gloria Barbosa-Sabanero, Sergio Solorio-Meza, and Myrna Sabanero-López. "Study of Electromagnetic Fields on Cellular Systems." Acta Universitaria 19 (September 1, 2009): 65–70. http://dx.doi.org/10.15174/au.2009.103.

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In the last decades the interest to study the effect of non-ionizing radiation, such as the electromagnetic fields (EMF) on cellular systems has increased. In this article the interaction between EMF and biological systems is described. An analysis of the effect of the electromagnetic stimulation at different frequencies and intensities on cell cultures is performed. Preliminary results show that the stimulation with extremely low frequency electromagnetic fields (ELF-EMF), EMF from 3 to 30 Hz, on the cellular line of neuroblastomaSK-NSH induces cellular stress. This is reflected by a variatio

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Barjaktarevic, Igor Z., Ronald G. Crystal, and Robert J. Kaner. "The Role of Interleukin-23 in the Early Development of Emphysema in HIV1+Smokers." Journal of Immunology Research 2016 (2016): 1–14. http://dx.doi.org/10.1155/2016/3463104.

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Rationale.Matrix metalloproteinase-9 (MMP-9) expression is upregulated in alveolar macrophages (AM) of HIV1+smokers who develop emphysema. Knowing that lung epithelial lining fluid (ELF) of HIV1+smokers contains increased levels of inflammatory cytokines compared to HIV1−smokers, we hypothesized that upregulation of lung cytokines in HIV1+smokers may be functionally related to increased MMP-9 expression.Methods.Cytokine arrays evaluated cytokine protein levels in ELF obtained from 5 groups of individuals: HIV1−healthy nonsmokers, HIV1−healthy smokers, HIV1−smokers with low diffusing capacity (

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Thompson, C. B., C. Y. Wang, I. C. Ho, et al. "cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1." Molecular and Cellular Biology 12, no. 3 (1992): 1043–53. http://dx.doi.org/10.1128/mcb.12.3.1043-1053.1992.

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The recent definition of a consensus DNA binding sequence for the Ets family of transcription factors has allowed the identification of potential Ets binding sites in the promoters and enhancers of many inducible T-cell genes. In the studies described in this report, we have identified two potential Ets binding sites, EBS1 and EBS2, which are conserved in both the human and murine interleukin-2 enhancers. Within the human enhancer, these two sites are located within the previously defined DNase I footprints, NFAT-1 and NFIL-2B, respectively. Electrophoretic mobility shift and methylation inter

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