Relevant bibliographies by topics / ELiposome

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'ELiposome'

Author: Grafiati
Published: 4 June 2021
Last updated: 8 February 2022

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Journal articles on the topic "ELiposome"

1

Lattin, James R., William G. Pitt, David M. Belnap, and Ghaleb A. Husseini. "Ultrasound-Induced Calcein Release From eLiposomes." Ultrasound in Medicine & Biology 38, no. 12 (December 2012): 2163–73. http://dx.doi.org/10.1016/j.ultrasmedbio.2012.08.001.

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2

Lattin, James R., and William G. Pitt. "Factors Affecting Ultrasonic Release from eLiposomes." Journal of Pharmaceutical Sciences 104, no. 4 (April 2015): 1373–84. http://dx.doi.org/10.1002/jps.24344.

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3

Javadi, Marjan, William G. Pitt, Christopher M. Tracy, Jeffery R. Barrow, Barry M. Willardson, Jonathan M. Hartley, and Naakaii H. Tsosie. "Ultrasonic gene and drug delivery using eLiposomes." Journal of Controlled Release 167, no. 1 (April 2013): 92–100. http://dx.doi.org/10.1016/j.jconrel.2013.01.009.

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4

Javadi, Marjan, William G. Pitt, David M. Belnap, Naakaii H. Tsosie, and Jonathan M. Hartley. "Encapsulating Nanoemulsions Inside eLiposomes for Ultrasonic Drug Delivery." Langmuir 28, no. 41 (October 4, 2012): 14720–29. http://dx.doi.org/10.1021/la303464v.

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5

Husseini, Ghaleb A., William G. Pitt, and Marjan Javadi. "Investigating the Stability of eLiposomes at Elevated Temperatures." Technology in Cancer Research & Treatment 14, no. 4 (September 26, 2014): 379–82. http://dx.doi.org/10.1177/1533034614551480.

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6

Lattin, J. R., D. M. Belnap, and W. G. Pitt. "Formation of eLiposomes as a drug delivery vehicle." Colloids and Surfaces B: Biointerfaces 89 (January 2012): 93–100. http://dx.doi.org/10.1016/j.colsurfb.2011.08.030.

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7

Lin, Chung-Yin, Marjan Javadi, David M. Belnap, Jeffery R. Barrow, and William G. Pitt. "Ultrasound sensitive eLiposomes containing doxorubicin for drug targeting therapy." Nanomedicine: Nanotechnology, Biology and Medicine 10, no. 1 (January 2014): 67–76. http://dx.doi.org/10.1016/j.nano.2013.06.011.

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8

Lin, Chung-Yin, William Pitt, and Kuo-Chen Wei. "Development of Ultrasound Sensitive eLiposomes Containing Doxorubicin for Drug Delivery." British Journal of Pharmaceutical Research 4, no. 19 (January 10, 2014): 2296–311. http://dx.doi.org/10.9734/bjpr/2014/13143.

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9

Husseini, Ghaleb A., William G. Pitt, Jacob B. Williams, and Marjan Javadi. "Investigating the Release Mechanism of Calcein from eLiposomes at Higher Temperatures." Journal of Colloid Science and Biotechnology 3, no. 3 (September 1, 2014): 239–44. http://dx.doi.org/10.1166/jcsb.2014.1100.

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Dissertations / Theses on the topic "ELiposome"

1

Lattin, James R. "Ultrasound-Induced Phase Change of Emulsion Droplets for Targeted Gene and Drug Delivery." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3377.

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This dissertation explores the potential of using perfluorocarbon emulsion droplets to add an ultrasound-sensitive element to drug delivery systems. These emulsion droplets may be induced to vaporize with ultrasound; during the rarefactional phase of an ultrasound wave, the pressure around the droplets may fall below the vapor pressure of the liquid forming the emulsion, providing a thermodynamic potential for vaporization. This ultrasound-induced phase change of the emulsion droplet could release therapeutics attached to the droplet surface or aid in drug delivery due to mechanical effects associated with vaporization and expansion, similar to the ability of cavitating bubbles to aid in drug delivery. In contrast to bubbles, stable emulsions can be formed at nano-scale sizes, allowing them to extravasate into tissues and potentially be endocytosed into cells. Perfluorohexane and perfluoropentane were selected to form the emulsions due to their relatively high vapor pressure, low water solubility, and biocompatibility. Acoustic droplet vaporization was explored for its potential to increase ultrasound-induced drug release from liposomes. Liposomes have proven to be versatile and effective drug carriers, but are not inherently responsive to ultrasound. eLiposomes, defined as a liposome with encapsulated emulsion droplets, were developed due to the potential of the expanding vapor phase to disrupt bilayer membranes. The resulting vesicle retains the advantages of liposomes for drug delivery, while adding an ultrasound-sensitive element. eLiposomes were loaded with calcein, a fluorescent molecule, as a model drug in order to quantify ultrasound-mediated drug release compared to release from conventional liposomes. Upon exposure to ultrasound, eLiposomes typically released 3 to 5 times as much of the encapsulated load compared to conventional liposomes, with some eLiposome samples approaching 100% release. Emulsion droplets were also added to the outside of conventional liposomes, but resulted in little to no increase compared to control samples without emulsions. Lastly, in vitro experiments were performed with HeLa cells to explore the ability of emulsion droplets and eLiposomes to deliver calcein inside of cells. Calcein delivery to the cytosol was accomplished, and the emulsion-containing samples demonstrated the ability to aid in endosomal escape.
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2

Hartley, Jonathan Michael. "Surface Modification of Liposomes Containing Nanoemulsions." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2846.

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Many attempts have been made to make cancer therapy more selective and less detrimental to the health of the patients. Nanoparticles have emerged as a way to solve some of the problems of traditional chemotherapy. Nanoparticles can provide protection for the therapeutic from degradation or clearance, as well as protection to healthy tissue from the damaging effects of chemotherapy drugs. Researchers are pursuing different strategies but all have the same goals of improving the outcomes of cancer patients. The field of controlled release of drugs has increased significantly in hopes of better treating diseases like cancer. Improved control of drug release has great potential for improving patient outcomes. Still there exist certain barriers such as circulation time, cell specificity, and endosomal escape.In this study a novel drug delivery vehicle was studied in vitro. The novel construct consisted of a liposome containing perfluorocarbon emulsions—an eLiposome—that was activated by ultrasound to break open on demand. Two targeting moieties were attached to the eLiposome to increase cell specificity and induce endocytosis. These studies determined the localization of eLiposomes in vitro using flow cytometry and confocal microscopy. Results indicated that eLiposomes modified with a targeting moiety attached to HeLa cells to a greater extent than non-targeting eLiposomes. Confocal images indicated localization of eLiposomes around the membrane of cells. Flow cytometer results indicated that ultrasound does in fact disrupt the eLiposomes but evidence of significant delivery to the cytoplasm was not obtained. However cells that were incubated with eLiposomes for 24 hours showed over 60% of the cells had green color association indicating eLiposome uptake.
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3

Williams, Jacob Brian. "Nanoemulsions Within Liposomes for Cytosolic Drug Delivery to Multidrug-Resistant Cancer Cells." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6211.

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Cancer cells that survive chemotherapy treatment often develop resistance to the administered chemotherapeutics, as well as to many other types of drugs, because the cancer cells increase their production of efflux pumps in the cell. This undesired phenomenon of resistance to cancer drugs is known as multidrug resistance. This work uses a novel drug carrier, called an eLiposome, to achieve cytosolic drug delivery to kill multidrug-resistant cancer cells. An eLiposome consists of a perfluoropentane (PFC5) emulsion droplet inside of a liposome. Folate attached to the eLiposome facilitates uptake into the cell. The PFC5 droplet is metastable at body temperature, but will rupture the liposome as the droplet expands during vaporization, and will release any drugs encapsulated inside of the liposome directly to the cell cytosol. Laser and ultrasound were examined as triggers to initiate the vaporization of the PFC5 droplet and actuate the release of doxorubicin (Dox) from folated eLiposomes containing Dox (feLD). Gold nanorods (GNRs) were synthesized and transferred to PFC5 droplets. Although GNRs are efficient at converting irradiated laser light to heat, no vaporization of the PFC5 droplets was observed when irradiated with laser light. Further investigation into the energy required for vaporization of PFC5 droplets revealed that there are currently no portable and wearable lasers available to provide enough energy to vaporize PFC5 droplets. Two seconds of ultrasound can release 78% of encapsulated Dox from feLD. Dox-sensitive KB-3-1 cells and Dox-resistant KB-V1 cells treated with feLD (without ultrasound) had cell viabilities of 33% and 60%, respectively. Ultrasound had negligible additional effect on the cell viability of KB-3-1 and KB-V1 cells treated with feLD (33% and 53%, respectively). We hypothesized that the Dox fiber formed during the loading of Dox into the eLiposome is a site for heterogeneous nucleation once the feLD is endocytosed by the cell, and vaporization and drug release occurs with or without ultrasound. Blocking the efflux pumps with verapamil decreases the rate at which Dox is exported from multidrug-resistant cells. When verapamil is co-delivered with feLD, the cell viability of KB-3-1 and KB-V1 cells decreases to 29% and 25%, respectively; thereby reversing the multidrug resistance possessed by KB-V1 cells. The delivery of doxorubicin inside of folated eLiposomes with an efflux pump blocker is a novel way to kill multidrug-resistant cancer cells as effectively as non-resistant cancer cells independent of lasers or ultrasound.
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4

Javadi, Marjan. "Novel Liposomes for Targeted Delivery of Drugs and Plasmids." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3879.

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People receiving chemotherapy not only suffer from side effects of therapeutics but also must buy expensive drugs. Targeted drug and gene delivery directed to specific tumor-cells is one way to reduce the side effect of drugs and use less amount of therapeutics. In this research, two novel liposomal nanocarriers were developed. This nanocarrier, called an eLiposome, is basically one or more emulsion droplets inside a liposome. Emulsion droplets are made of perfluorocarbons which usually have a high vapor pressure. Calcein (as a model drug) and Paclitaxel were used to demonstrate drug delivery, and plasmids and siRNA were used to exemplify gene delivery. Drugs or genes were encapsulated inside the interior of the liposomes along with emulsion droplets; targeting moieties were attached to the outside of the phospholipid bilayer. Ultrasound was used to break open the bilayer by changing the liquid emulsion droplets to gas, which released the content of the eLiposomes. Transmission electron microscopy (TEM) was used to prove the formation of eLiposomes and confocal microscopy showed the uptake of drugs and genes in vitro. Cell viability was measured to show the effect of uptake in cancer cells. Results indicate that eLiposomes were successfully made and that they were endocytosed into the cell. It was observed that the emulsion and the targeting moiety in combination with ultrasound are the essential elements required to produce release from eLiposomes.
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