Relevant bibliographies by topics / ELLIPTICINE

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  2. Dissertations / Theses
  3. Books
  4. Book chapters
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Academic literature on the topic 'ELLIPTICINE'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 February 2022

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Journal articles on the topic "ELLIPTICINE"

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Poljaková, Jitka, Martin Dračínský, Eva Frei, Jiří Hudeček, and Marie Stiborová. "The Effect of pH on Peroxidase-Mediated Oxidation of and DNA Adduct Formation by Ellipticine." Collection of Czechoslovak Chemical Communications 71, no. 8 (2006): 1169–85. http://dx.doi.org/10.1135/cccc20061169.

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In order to understand the mechanism of enzymatic activation of an antineoplastic agent ellipticine, we investigated the effect of pH on the efficiency of three model peroxidases (bovine lactoperoxidase, human myeloperoxidase and horseradish peroxidase) in oxidation of ellipticine and in formation ellipticine-DNA adducts. The formation of the major ellipticine metabolite, ellipticine dimer, in which two ellipticine residues are connected through nitrogenN6in the pyrrole ring of one of the ellipticine moieties and carbon C9 of the other ellipticine, and formation of four ellipticine-DNA adducts
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Lin, Jingjing, Mei Tang, Ru Zhao, et al. "Synthetic Optimization of Ellipticine and Antitumor Activity of Novel Hexacyclic Derivatives of Ellipticine." Current Pharmaceutical Design 25, no. 33 (2019): 3578–89. http://dx.doi.org/10.2174/1381612825666190404122650.

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Background: For decades, a great deal of research work has been done to synthesize ellipticine and its derivatives because of their potential antitumor properties and anti-HIV activities. However, the resonance structures in different media, a low level of solubility at physiological pH and systemic toxicity have prevented the use of ellipticine as a therapeutic agent. Besides, the low yield and complex steps of ellipticine synthesis limit its application. Methods: A high-yield synthetic procedure of ellipticine has been optimized, and the total yield was up to 50% without silica gel column ch
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Poljaková, Jitka, Tomáš Eckschlager, Jana Hřebačková, Jan Hraběta, and Marie Stiborová. "The comparison of cytotoxicity of the anticancer drugs doxorubicin and ellipticine to human neuroblastoma cells." Interdisciplinary Toxicology 1, no. 2 (2008): 186–89. http://dx.doi.org/10.2478/v10102-010-0036-9.

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The comparison of cytotoxicity of the anticancer drugs doxorubicin and ellipticine to human neuroblastoma cellsEllipticine is an antineoplastic agent, whose mode of action is based mainly on DNA intercalation, inhibition of topoisomerase II and formation of covalent DNA adducts mediated by cytochromes P450 and peroxidases. Here, the cytotoxicity of ellipticine to human neuroblastoma derived cell lines IMR-32 and UKF-NB-4 was investigated. Treatment of neuroblastoma cells with ellipticine was compared with that of these cancer cells with doxorubicin. The toxicity of ellipticine was essentially
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Bořek-Dohalská, Lucie, Eva Frei, and Marie Stiborová. "DNA Adduct Formation by the Anticancer Drug Ellipticine and Its Hydroxy Derivatives in Human Breast Adenocarcinoma MCF-7 Cells." Collection of Czechoslovak Chemical Communications 69, no. 3 (2004): 603–15. http://dx.doi.org/10.1135/cccc20040603.

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The cytotoxicity of the antineoplastic agent ellipticine and its 9- and 7-hydroxylated metabolites to human breast adenocarcinoma MCF-7 cells and their ability to generate DNA adducts in these cancer cells were investigated. Ellipticine and its 9-hydroxylated metabolite were found to be toxic to MCF-7 cells with IC50 values of 1.25 and 3.25 μmol l-1 for ellipticine and 9-hydroxyellipticine, respectively. In contrast, no toxicity to these cancer cells was detectable for 7-hydroxyellipticine. The nuclease P1 version of the 32P-postlabeling assay yielded a pattern of ellipticine-DNA adducts with
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Pohlit, A. M., L. F. Rocha e Silva, M. C. Henrique, et al. "Antimalarial activity of ellipticine." Phytomedicine 19, no. 11 (2012): 1049. http://dx.doi.org/10.1016/j.phymed.2012.06.005.

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Ho, Tse-Lok, and Sheng-Ying Hsieh. "Regioselective Synthesis of Ellipticine." Helvetica Chimica Acta 89, no. 1 (2006): 111–16. http://dx.doi.org/10.1002/hlca.200690001.

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Aimová, Dagmar, Jitka Poljaková, Věra Kotrbová, et al. "Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2." Interdisciplinary Toxicology 1, no. 2 (2008): 160–68. http://dx.doi.org/10.2478/v10102-010-0033-z.

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Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2Two compounds known to covalently bind to DNA after their activation with cytochromes P450 (CYPs), carcinogenic benzo(a)pyrene (BaP) and an antineoplastic agent ellipticine, were investigated for their potential to induce CYP and NADPH:CYP reductase (POR) enzymes in rodent livers, the main target organ for DNA adduct formation. Two animal models were used in the study: (i) rats as animals mimicking the fate of ellipticine in humans and (ii) m
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Alunni-Bistocchi, Giovanni, Pierluigi Orvietani, Olivier Mauffret, et al. "Isomeric ellipticines. Part 1. Synthesis of two linear isomers of the antitumour alkaloid ellipticine." Journal of the Chemical Society, Perkin Transactions 1, no. 21 (1992): 2935. http://dx.doi.org/10.1039/p19920002935.

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McKee, Mary L., Limian Zheng, Elaine C. O’Sullivan, et al. "Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of Phytophthora infestans." Pathogens 9, no. 7 (2020): 558. http://dx.doi.org/10.3390/pathogens9070558.

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The pathogen Phytophthora infestans is responsible for worldwide catastrophic crop damage and discovery of new inhibitors of this organism is of paramount agricultural and industrial importance. Current strategies for crop treatment are inadequate with limitations of efficacy and market alternatives. Ellipticines have recently been reported to have fungicidal properties and have been assessed against P. infestans growth with promising results. We hereby report a probe of the ellipticine framework to investigate the alkyl subunit and screen a set ellipticines and derivatives to identify new lea
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Stiborová, Marie, Helena Dračínská, Dagmar Aimová, et al. "The Anticancer Drug Ellipticine is an Inducer of Rat NAD(P)H:Quinone Oxidoreductase." Collection of Czechoslovak Chemical Communications 72, no. 10 (2007): 1350–64. http://dx.doi.org/10.1135/cccc20071350.

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The antineoplastic agent ellipticine was investigated for its ability to induce the biotransformation enzyme NAD(P)H:quinone oxidoreductase (DT-diaphorase, EC 1.6.99.2) in male Wistar rats. Using the real-time polymerase chain reaction, the levels of NAD(P)H:quinone oxidoreductase mRNA were determined in livers, kidneys and lungs of rats treated intraperitoneally with ellipticine (40 mg/kg body weight) and of control (untreated) rats. Cytosolic fractions were isolated from the same tissues of control and ellipticine-treated rats and tested for NAD(P)H:quinone oxidoreductase protein expression
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Dissertations / Theses on the topic "ELLIPTICINE"

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Dufour, Fabien. "Synthèse en série carbazolique, analogues d'ellipticine, et dihydrocarbazolocarbazoles." Thesis, Metz, 2007. http://www.theses.fr/2007METZ031S/document.

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L’ellipticine, alcaloïde tétracyclique naturel au squelette 6H-pyrido[4,3-b]carbazole, et certains de ses dérivés possèdent des propriétés antitumorales. L’objectif de ce travail a été, d’une part de trouver une méthode de synthèse de deux types d’intermédiaires précis non décrits à notre connaissance (dérivés du carbazole et de la pyridine), puis de synthétiser des analogues d’ellipticine possédant un cycle saturé supplémentaire, ces modifications structurales pouvant être intéressantes du point de vue de l’activité biologique. Initialement envisagée à partir de dérivés du furane par ouvertur
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Hayler, John David. "Approaches to carbon analogues of ellipticine." Thesis, University of Bath, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381194.

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Gautier, Claudie. "Synthèse d'oligodésoxynucléotides d'anomérie alpha ou bêta liés à des dérivés de l'ellipticine : propriétés physicochimiques d'interaction avec les acides nucléiques." Paris 6, 1987. http://www.theses.fr/1987PA066389.

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Dufour, Fabien Kirsch Gilbert. "Synthèse en série carbazolique, analogues d' ellipticine, et dihydrocarbazolocarbazolzq." [S.l.] : [s.n.], 2007. ftp://ftp.scd.univ-metz.fr/pub/Theses/2007/Dufour.F.SMZ0731.pdf.

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Vong, Kuok Keong. "Syntheses of ring A substituted ellipticines." Thesis, University of Bath, 1987. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378602.

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Akue-Gedu, Rufine. "Conception rationnelle et synthèse d'inhibiteurs potentiels de la topoisomérase II : synthèse complète de la camptothécine." Lille 2, 2004. http://www.theses.fr/2004LIL2S013.

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Les topoisomérases sont la cible de certains médicaments anticancéreux. L’ellipticine et ses dérivés sont de bons modèles d’inhibiteurs de la topoisomérase II. Ils interagissent aussi directement avec l’ADN par intercalation. L’acétate de 2-N-méthyl-9-méthoxyelliptinium (CEPTIUM*) a été utilisé en clinique dans le traitement du cancer du sein. Il est retiré du marché à cause de sa forte toxicité. Le but de notre travail est de concevoir et de synthétiser de nouvelles molécules analogues de l’ellipticine en modifiant sa structure par pharmacomodulation. Nous proposons également une synthèse com
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Castin, Isabelle. "Synthèse d'analogues de l'hydroxy-9 ellipticine réactivité dans des conditions oxydatives /." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb376125202.

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Castin, Isabelle. "Synthèse d'analogues de l'hydroxy-9 ellipticine : réactivité dans des conditions oxydatives." Paris 11, 1988. http://www.theses.fr/1988PA112176.

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Les travaux relatés dans ce mémoire s'inscrivent dans le cadre d'une meilleure compréhension du mode d'action de l'acétate dhydroxy-9 N Méthyl -2 ellipticinium, dérivé de l'ellipticine, et de l'évaluation de l'activité cytotoxique de certain de ses analogues. Ce travail est présenté en trois parties :La première partie décrit la réactivité régiospécifique du groupement hydroxy-5 indole de l'hydroxy-9 ellipticine dans des conditions oxydatives. Cette réactivité est illustrée à l'aide du diméthyle-Piyle-1 ,4 hydroxy-6 carbazole qui, dans sa forme au quinonelmine, peut conduire à des additions de
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Lejoyeux, Pierre. "Interaction d'une série alkyloxazolopyridocarbazole avec des liposomes : étude thermodynamique et cinétique." Paris 5, 1989. http://www.theses.fr/1989PA05P009.

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Pikhartova-Martinkova, Eva. "Combination of ellipticine chemotherapy and alpha5beta1 integrin-targeted therapy in human glioblastoma." Strasbourg, 2010. https://publication-theses.unistra.fr/restreint/theses_doctorat/2010/PIKHARTOVA-MARTINKOVA_Eva_2010.pdf.

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Les glioblastomes sont des tumeurs cérébrales agressives pour lesquelles les thérapies classiques se révèlent souvent inefficaces. Les intégrines peuvent aussi réguler l’angiogénèse, l’embryogenèse, la prolifération, la différentiation, la migration et la survie. Nous avons proposé l`intégrine α5β1 comme un cible thérapeutique pour les glioblastomes, comme elle est surexprimée dans les gliomes en fonction du grade tumoral et comme les travaux récents l`indiquent ayant un rôle central dans un réseau fonctionnel de la cellule tumoral. Les deux lignées cellulaires de glioblastome testés (U87MG et
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Books on the topic "ELLIPTICINE"

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Street, Brian. The Calder´on-Zygmund Theory I: Ellipticity. Princeton University Press, 2017. http://dx.doi.org/10.23943/princeton/9780691162515.003.0001.

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This chapter discusses a case for single-parameter singular integral operators, where ρ‎ is the usual distance on ℝn. There, we obtain the most classical theory of singular integrals, which is useful for studying elliptic partial differential operators. The chapter defines singular integral operators in three equivalent ways. This trichotomy can be seen three times, in increasing generality: Theorems 1.1.23, 1.1.26, and 1.2.10. This trichotomy is developed even when the operators are not translation invariant (many authors discuss such ideas only for translation invariant, or nearly translatio
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Steigmann, David J. Material stability, strong ellipticity and smoothness of equilibria. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198567783.003.0009.

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Chapter 9 develops the notion of material stability on the basis of small-amplitude wave propagation. This is shown to correlate with the smoothness of finite equilibrium deformations, granted sufficient a priori regularity assumptions. The central role played by the condition of strong ellipticity is emphasized.
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Maggiore, Michele. Neutron stars. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198570899.003.0002.

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Observation of neutron stars as pulsars. Pulsar demography. Magnetars. GW emission from neutron stars. Normal modes of neuton stars. CFS instability; r-mode instability. GWs from the post-merger NS remnant. Ellipticity of deformed neutron stars.
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Book chapters on the topic "ELLIPTICINE"

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Joule, John A. "The Uleine-Ellipticine-Vallesamine Group." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186954.ch6.

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Aubard, J., J. P. Marsault, G. Levi, L. Chinsky, F. Sureau, and P. Y. Turpin. "UV Resonance Raman Study of Ellipticine and Derivatives." In Fifth International Conference on the Spectroscopy of Biological Molecules. Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1934-4_94.

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Chénieux, J. C., E. G. Ramawat, and M. Rideau. "Ochrosia spp.: In Vitro Production of Ellipticine, an Antitumor Agent." In Biotechnology in Agriculture and Forestry. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73026-9_24.

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Sainsbury, M. "Ellipticines." In The Chemistry of Antitumour Agents. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0397-5_18.

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Liu, Xiaochun, and Bert-Wolfgang Schulze. "Boundary ellipticity." In Boundary Value Problems with Global Projection Conditions. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-70114-1_11.

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Liu, Xiaochun, and Bert-Wolfgang Schulze. "Edge-ellipticity." In Boundary Value Problems with Global Projection Conditions. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-70114-1_8.

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Liu, Xiaochun, and Bert-Wolfgang Schulze. "Shapiro–Lopatinskii ellipticity." In Boundary Value Problems with Global Projection Conditions. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-70114-1_3.

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Aktaş, Mehmet Ali, and Joviša Žunić. "Measuring Shape Ellipticity." In Computer Analysis of Images and Patterns. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-23672-3_21.

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Rusconi, Luigia, and Giorgio Sedmak. "Binary Slice Fit Ellipticity Analysis." In Data Analysis in Astronomy. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4615-9433-8_9.

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Schulze, B. W. "Ellipticity with Global Projection Conditions." In Trends in Mathematics. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47512-7_4.

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Conference papers on the topic "ELLIPTICINE"

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McCarthy, Florence, and Mary McKee. "Synthesis and evaluation of novel ellipticine salt derivatives as anticancer agents." In 4th International Electronic Conference on Medicinal Chemistry. MDPI, 2018. http://dx.doi.org/10.3390/ecmc-4-05638.

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Trnkova, Libuse, Dalibor Huska, Vojtech Adam, et al. "Electrochemical biosensor for investigation of anticancer drugs interactions (doxorubicin and ellipticine) with DNA." In 2009 IEEE Sensors. IEEE, 2009. http://dx.doi.org/10.1109/icsens.2009.5398361.

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Letellier, R., E. Taillandier, J. R. Bertrand, and C. Malvy. "Molecular mechanical study of the insertion of 9-amino ellipticine in DNA containing true abasic sites." In Advances in biomolecular simulations. AIP, 1991. http://dx.doi.org/10.1063/1.41324.

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Onel, Buket, Prashansa Agrawal, Megan Carver, Laurence H. Hurley та Danzhou Yang. "Abstract 5230: Targeting two unique end-insertion G-quadruplexes formed in the 3′-end of the PDGFR-β core promoter nuclease hypersensitive element with ellipticine analog". У Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-5230.

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Frei, Eva, Vera Kotrbova, Vaclav Martinek, Andrea Breuer, and Marie Stiborova. "Abstract 5419: The plant alkaloid ellipticine is detoxified by cytochrome P450 1A1/2 (CYP 1A1/2) but activated and forms DNA adducts if CYP1A1 or 1A2 is combined with cytochrome b5: an explanation for anin vivo/in vitrodiscrepancy." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-5419.

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Coronel, Ruben. "The Ellipticity of Galaxy Clusters at a Large Radius." In The Ellipticity of Galaxy Clusters at a Large Radius. US DOE, 2020. http://dx.doi.org/10.2172/1656623.

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Gurbuz, O. D., C. H. Ko, J. Edwards, and G. M. Rebeiz. "Pattern ellipticity for silicon lenses." In 2013 IEEE International Symposium on Antennas and Propagation & USNC/URSI National Radio Science Meeting. IEEE, 2013. http://dx.doi.org/10.1109/aps.2013.6711241.

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Baranyi, La´szlo´. "Energy Transfer Between an Orbiting Cylinder and Moving Fluid." In ASME 2006 Pressure Vessels and Piping/ICPVT-11 Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/pvp2006-icpvt-11-93955.

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This paper deals with the numerical simulation of low Reynolds number flow past a circular cylinder in orbital motion. Energy transfer between the incompressible fluid and a circular cylinder forced to follow an orbital path is investigated as a function of ellipticity. Limit cycles were investigated and show that ellipticity can have a large effect on the energy transfer. Sudden changes in state (jumps) were found when energy transfer is plotted against ellipticity. Phase angle was altered by about 180° at the jumps. The effect of direction of orbit and initial conditions was also investigate
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Wang, Xu. "Ellipticity Dependence of Nonsequential Double Ionization." In Laser Science. OSA, 2010. http://dx.doi.org/10.1364/ls.2010.ltue3.

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Becquey, M., and M. Manin. "Ellipticity filter for ground-roll removal." In 58th EAEG Meeting. EAGE Publications BV, 1996. http://dx.doi.org/10.3997/2214-4609.201409167.

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Reports on the topic "ELLIPTICINE"

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Schlaufman, K. SIMULATIONS OF TURBULENCE INDUCED ELLIPTICITY OVER LARGE FIELDS-OF-VIEW: THE FIRST STEP TOWARDS ENABLING LSST WEAK LENSING SCIENCE. Office of Scientific and Technical Information (OSTI), 2004. http://dx.doi.org/10.2172/15014580.

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