Academic literature on the topic 'Embryotoxicity test'

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Journal articles on the topic "Embryotoxicity test"

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Peterka, M., and R. Peterkova. "Estimation of isotretinoin embryotoxicity using the chick embryotoxicity test." Reproductive Toxicology 6, no. 2 (1992): 184. http://dx.doi.org/10.1016/0890-6238(92)90144-i.

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Maňáková, Eva, Lucie H. Hubičková, Jana Košťálová, and Zdena Zemanová. "Embryotoxicity of Mirtazapine: A study using Chick Embryotoxicity Screening Test." Reproductive Toxicology 30, no. 2 (2010): 240–41. http://dx.doi.org/10.1016/j.reprotox.2010.05.066.

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Romero, Andrea C., Eugenio Vilanova, and Miguel A. Sogorb. "Shortening and Improving the Embryonic Stem Cell Test through the Use of Gene Biomarkers of Differentiation." Journal of Toxicology 2011 (2011): 1–8. http://dx.doi.org/10.1155/2011/286034.

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The embryonic Stem cell Test (EST) is a validated assay for testing embryotoxicityin vitro. The total duration of this protocol is 10 days, and its main end-point is based on histological determinations. It is suggested that improvements on EST must be focused toward molecular end-points and, if possible, to reduce the total assay duration. Five days of exposure of D3 cells in monolayers under spontaneous differentiation to 50 ng/mL of the strong embryotoxic 5-fluorouracil or to 75 μg/mL of the weak embryotoxic 5,5-diphenylhydeantoin caused between 20 and 74% of reductions in the expression of
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Boehn, Susanne, Hennicke Kamp, Tanja Kaufmann, et al. "Modification and evaluation of the chicken embryotoxicity screening test (CHEST) as in vitro test system for embryotoxicity." Toxicology Letters 189 (September 2009): S82. http://dx.doi.org/10.1016/j.toxlet.2009.06.248.

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Lingfeng Li, Zhen Chen, Zihe Zheng, and Xiaofu Dai. "Toxicology of milrinone by zebrafish embryotoxicity test." Cellular and Molecular Biology 70, no. 5 (2024): 82–88. http://dx.doi.org/10.14715/cmb/2024.70.5.12.

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Delaroche, L., P. Oger, E. Genauzeau, et al. "Embryotoxicity testing of IVF disposables: how do manufacturers test?" Human Reproduction 35, no. 2 (2020): 283–92. http://dx.doi.org/10.1093/humrep/dez277.

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Abstract STUDY QUESTION How do manufacturers perform embryotoxicity testing in their quality control programs when validating IVF consumables? SUMMARY ANSWER The Mouse Embryo Assay (MEA) and Human Sperm Survival Assay (HSSA) used for IVF disposables differed from one manufacturer to another. WHAT IS KNOWN ALREADY Many components used in IVF laboratories, such as culture media and disposable consumables, may negatively impact human embryonic development. STUDY DESIGN, SIZE, DURATION Through a questionnaire-based survey, the main manufacturers of IVF disposable devices were contacted during the
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Imai, Koichi, Fumio Watari, Kazuaki Nakamura, and Akito Tanoue. "Study of the C60 Fullerene on Differentiation of Mouse Embryonic Stem Cells." Key Engineering Materials 529-530 (November 2012): 385–90. http://dx.doi.org/10.4028/www.scientific.net/kem.529-530.385.

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The risks of nanomaterials for future generations should be elucidated. Thus, it is important to establish an experimental method to accurately examine embryotoxicity. We have conducted anin vitroembryotoxicity test with mouse ES cells to examine the embryotoxicities of various nanomaterials. In this study, the C60 fullerene did not influence the differentiation of ES-D3 cells and "non embryotoxicity". In the future, the biological safety should be comprehensively examined by improving dispersion in medium.
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Hermsen, Sanne A. B., Evert-Jan van den Brandhof, and Aldert H. Piersma. "Relative embryotoxicity of 1,2,4-triazoles in the zebrafish embryotoxicity test and comparison with their in vivo potencies." Reproductive Toxicology 30, no. 2 (2010): 238. http://dx.doi.org/10.1016/j.reprotox.2010.05.060.

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Manzo, S. "Sea urchin embryotoxicity test: proposal for a simplified bioassay." Ecotoxicology and Environmental Safety 57, no. 2 (2004): 123–28. http://dx.doi.org/10.1016/j.ecoenv.2003.10.007.

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Walker, Lauren Michelle, Nicole R. L. Sparks, Veronica Puig-Sanvicens, Beatriz Rodrigues, and Nicole I. zur Nieden. "An Evaluation of Human Induced Pluripotent Stem Cells to Test for Cardiac Developmental Toxicity." International Journal of Molecular Sciences 22, no. 15 (2021): 8114. http://dx.doi.org/10.3390/ijms22158114.

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To prevent congenital defects arising from maternal exposure, safety regulations require pre-market developmental toxicity screens for industrial chemicals and pharmaceuticals. Traditional embryotoxicity approaches depend heavily on the use of low-throughput animal models which may not adequately predict human risk. The validated embryonic stem cell test (EST) developed in murine embryonic stem cells addressed the former problem over 15 years ago. Here, we present a proof-of-concept study to address the latter challenge by updating all three endpoints of the classic mouse EST with endpoints de
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Dissertations / Theses on the topic "Embryotoxicity test"

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Gonçalves, Micael Ferreira Mota. "Development of novel short and long term studies in Enchytraeus crypticus." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/18562.

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Mestrado em Biologia Molecular e Celular<br>A maioria dos estudos ecotoxicológicos têm investigado os efeitos de curto prazo dos contaminantes. Comparativamente, tem sido desenvolvido pouco trabalho na avaliação dos efeitos a longo prazo dos químicos existindo portanto uma necessidade de preencher esta lacuna. De entre as espécies de solo usadas em ecotoxicologia estão os Enquitraídeos (Oligochaeta), membros importantes da mesofauna terrestre com diretrizes padrão para testar os efeitos ao nível da sobrevivência, reprodução e bioacumulação (ISO, 2004; OECD, 2010, 2004). Para a espécie Enchytra
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Emelogu, Emmanuel Steven. "Combined effects of bioavailable organic contaminants in the aquatic environment." Thesis, Robert Gordon University, 2013. http://hdl.handle.net/10059/840.

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Passive sampling, as opposed to the conventional spot or bottle water sampling technique, has shown to be reliable and efficient in monitoring the toxicologically relevant, freely dissolved (e.g. bioavaialable) concentrations of a wide range of organic contaminants in water. At the same time, partitioning controlled delivery (passive dosing; PD) techniques promise to overcome many of the challenges associated with toxicity testing of hydrophobic substances that may bias the interpretation of toxicity data. The present study investigated the feasibility of coupling silicone rubber passive sampl
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Nahon, Sarah. "Contribution à l’étude de l'impact du stress radiatif ultraviolet sur les communautés benthiques de Méditerranée Nord Occidentale : importance des effets directs et des relations trophiques." Paris 6, 2009. http://www.theses.fr/2009PA066598.

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Dans le contexte général du changement global et du développement durable, il apparaît indispensable d’apprécier le risque qu’encourent les écosystèmes côtiers sous l’effet d’une augmentation du flux des radiations UVB. L‘objectif général de cette thèse est de contribuer à la caractérisation et à la quantification des effets du rayonnement UV sur les invertébrés benthiques de Méditerranée. La première partie de cette thèse est consacrée à l’étude de l’impact direct du rayonnement UV sur la reproduction et le développement précoce des invertébrés benthiques à cycle de vie bentho-pélagique. L’ex
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Špačková, Dagmara. "Možnosti prevence alkoholismu, test embryotoxicity disulfiramu." Master's thesis, 2006. http://www.nusl.cz/ntk/nusl-268111.

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Books on the topic "Embryotoxicity test"

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In Vitro Embryotoxicity and Teratogenicity Test (Concepts in Toxicology Vol. 3). S. Karger AG (Switzerland), 1985.

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Book chapters on the topic "Embryotoxicity test"

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Davies, Wendy J., and Stuart J. Freeman. "Chick Embryotoxicity Screening Test (CHEST I and II)." In In Vitro Toxicity Testing Protocols. Humana Press, 1995. http://dx.doi.org/10.1385/0-89603-282-5:307.

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Spielmann, H., I. Pohl, B. Döring, M. Liebsch, and F. Moldenhauer. "The embryonic stem cell test (EST), an in vitro embryotoxicity test using two permanent mouse cell lines: 3T3 fibroblasts and embryonic stem cells." In Ersatz- und Ergänzungsmethoden zu Tierversuchen. Springer Vienna, 1998. http://dx.doi.org/10.1007/978-3-7091-7500-2_69.

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Hermsen, Sanne A. B., and Aldert H. Piersma. "Implementation of Transcriptomics in the Zebrafish Embryotoxicity Test." In Toxicogenomics-Based Cellular Models. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-397862-2.00007-3.

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Nakamura, Kazuaki, Shinji Kusakawa, and Akito Tanoue. "Assessment of Embryotoxicity and Teratogenicity by the Embryonic Stem Cell Test." In Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications. InTech, 2011. http://dx.doi.org/10.5772/14644.

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