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Journal articles on the topic 'Emetic substances'

Author: Grafiati

Published: 5 September 2021

Last updated: 29 July 2025

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1

Walmsley, Darby W., Jonathan P. Bray, and Philip Thomas. "Apomorphine hydrochloride: a clinical review with retrospective analysis of use in 1126 dogs treated in emergency practice." Companion Animal 24, no. 8 (2019): 419–25. http://dx.doi.org/10.12968/coan.2019.0018.

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Apomorphine is a non-selective dopamine agonist commonly used in veterinary medicine for the emergency management of toxicoses in dogs, through the induction of emesis. This review evaluates the currently reported effectiveness, adverse effects and recommendations of apomorphine as an emetic and considers alternatives. This is complemented by a retrospective study of 1126 dogs treated with apomorphine in emergency practice, to determine the efficacy of apomorphine in a clinical setting, and to provide identification of population characteristics, indications and outcomes of treated patients. T

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2

Carpenter, D. O., D. B. Briggs, A. P. Knox, and N. Strominger. "Excitation of area postrema neurons by transmitters, peptides, and cyclic nucleotides." Journal of Neurophysiology 59, no. 2 (1988): 358–69. http://dx.doi.org/10.1152/jn.1988.59.2.358.

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1. Multiple-barreled microelectrodes were used to record from neurons in the area postrema of anesthetized dogs and to test the responses of the neurons to a variety of substances in this structure, which is known to function as the chemoceptive trigger zone for emesis. 2. The neurons in area postrema were silent at rest but could be "found" by virtue of their response to ionophoretic glutamate. The glutamic response was brief and of short latency with high frequency of discharge. 3. Dog area postrema neurons were also excited by over 20 other substances, including acetylcholine, the biogenic

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3

Meredith, T. J., and J. A. Vale. "Treatment of Paraquat Poisoning in Man: Methods to Prevent Absorption." Human Toxicology 6, no. 1 (1987): 49–55. http://dx.doi.org/10.1177/096032718700600108.

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Theoretically, absorption of an ingested dose of paraquat may be reduced by (1) gastric lavage, (2) induced emesis, (3) whole-gut lavage or (4) by the oral administration of adsorbent substances. 1 Animal experiments suggest that paraquat is absorbed poorly from the stomach and absorbed incompletely (< 5%) from the small intestine over a 1-6-h period. Although gastric lavage would therefore seem a logical way to ameliorate the toxicity of an ingested dose of paraquat, peak plasma concentrations are attained rapidly and evidence for the efficacy of gastric lavage in man is poor. 2 In 1977, a

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4

Blebea, Nicoleta Mirela, Laura Adriana Bucur, and Simona Negreș. "The cannabinoids – important therapeutic approach in the field of oncology." Romania Journal of Pharmaceutical Practice 57, no. 2 (2021): 63–67. http://dx.doi.org/10.37897/rjphp.2021.2.1.

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Oncological diseases are the most common cause of death worldwide, it is estimated that 25% of the population will face the diagnosis of cancer during life. Phytochemicals such as cannabinoids (CBs) have been used in various branches of medicine for their properties, and the discovery of the anti-tumor, anti-emetic and anti-inflammatory effects of some of these substances has encouraged their use in oncology. Phytocannabinoids, cannabidiol (CBD) and Δ-9-tetra-hydrocannabinol (THC), have numerous anti-emetic, analgesic, orexigenic, anti-inflammatory / immunosuppressive pharmacodynamic effects.

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5

Nakajima, Sadahiko. "Pica caused by emetic drugs in laboratory rats with kaolin, gypsum, and lime as test substances." Physiology & Behavior 261 (March 2023): 114076. http://dx.doi.org/10.1016/j.physbeh.2023.114076.

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6

Coelho, Larissa D., Mirna M. D. Souza, Geovanni D. Cassali, et al. "Emetic Tartar-Loaded Liposomes as a New Strategy for Leishmaniasis Treatment." Pharmaceutics 15, no. 3 (2023): 904. http://dx.doi.org/10.3390/pharmaceutics15030904.

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Emetic tartar (ET), was used in the treatment of leishmaniasis but its use was discontinued due to its low therapeutic index. Liposomes have been shown to be a promising strategy for delivery of bioactive substances in the region of interest, in order to reduce and/or eliminate undesirable effects. In the present study, liposomes containing ET were prepared and characterized to evaluate acute toxicity as well as their leishmanicidal action using BALB/c mice with an inoculum of Leishmania (Leishmania) infantum. Liposomes were composed of egg phosphatidylcholine and 3ß-[N-(N′,N′-dimethylaminoeth

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7

Shahrajabian, M. H., W. Sun, M. Khoshkharam, H. Shen, and Q. Cheng. "STUDY OF CHINESE HONEY LOCUST (GLEDITSIA SINENSIS) AND SHALLOT (ALLIUM ASCALONICUM L.) FOR INTEGRATE TRADITIONAL CHINESE MEDICINE INTO OTHER COUNTRIES' MEDICINE IN ORDER TO IMPROVE PUBLIC HEALTH." Labour protection problems in Ukraine 36, no. 2 (2020): 8–14. http://dx.doi.org/10.36804/nndipbop.36-2.2020.8-14.

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The population health is an important component of the country development, since the working capacity and workers' safety in the workplace depends on their health status. Toxic substances that are used the manufacturing process often cause allergies, inflammatory processes of the skin and internal organs, sometimes diabetes and cancer. To strengthen immunity and improve the health of workers, traditional Chinese medicine, which has achieved great success at present, can be recommended. The aim of this manuscript is review of health benefits and pharmaceutical impacts of Chinese honey locust a

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8

Arsenos, G., and I. Kyriazakis. "The continuum between conditioned preferences and aversions in ruminants to flavoured foods associated with the increasing administration of casein doses." Proceedings of the British Society of Animal Science 1998 (1998): 27. http://dx.doi.org/10.1017/s1752756200596793.

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In recent years there has been an increasing interest in the question of how ruminants develop conditioned flavour preferences or aversions (CFP's, CFA's) towards food flavours associated with the administration of various substances. Several studies have shown that ruminants are able to develop CFA's when pairing a novel food flavour with the administration of secondary compounds which lead to adverse post-ingestive consequences (e.g. activation of the emetic system, hypocalcaemia, Kyriazakis et al., 1997). In addition, CFP's, can be developed through associations between the food properties

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Arsenos, G., and I. Kyriazakis. "The continuum between conditioned preferences and aversions in ruminants to flavoured foods associated with the increasing administration of casein doses." Proceedings of the British Society of Animal Science 1998 (1998): 27. http://dx.doi.org/10.1017/s0308229600032402.

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In recent years there has been an increasing interest in the question of how ruminants develop conditioned flavour preferences or aversions (CFP's, CFA's) towards food flavours associated with the administration of various substances. Several studies have shown that ruminants are able to develop CFA's when pairing a novel food flavour with the administration of secondary compounds which lead to adverse post-ingestive consequences (e.g. activation of the emetic system, hypocalcaemia, Kyriazakis et al., 1997). In addition, CFP's, can be developed through associations between the food properties

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10

Nevadunsky, Nicole S., and Ursula A. Matulonis. "Chemotherapy-induced Nausea and Vomiting." Oncology & Hematology Review (US) 05, no. 01 (2009): 10. http://dx.doi.org/10.17925/ohr.2009.05.1.10.

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Nausea and vomiting are commonly observed and feared side effects of chemotherapy. Understanding of the physiological mechanisms of chemotherapy-induced nausea and vomiting (CINV) has led to the development of several classes of anti-emetic, including substance P antagonists, serotonin antagonists, and dopamine antagonists. The newest of these agents include aprepitant and palonosetron, which are very effective in treating emesis in highly emotegenic chemotherapies. Several organizations, including the Multinational Association of Supportive Care in Cancer (MASCC), the National Comprehensive C

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11

Gesztesi, Zsuzsanna, Phillip E. Scuderi, Paul F. White, et al. "Substance P (Neurokinin-1) Antagonist Prevents Postoperative Vomiting after Abdominal Hysterectomy Procedures." Anesthesiology 93, no. 4 (2000): 931–37. http://dx.doi.org/10.1097/00000542-200010000-00009.

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Background The safety and antiemetic efficacy of CP-122,721, a novel neurokinin-1 antagonist, was evaluated when administered alone or in combination with ondansetron. Methods Using a randomized, double-blind, placebo-controlled study design, CP-122,721 was initially compared with placebo and subsequently to ondansetron alone and in combination for prophylaxis against postoperative nausea and vomiting in 243 women undergoing abdominal hysterectomy. In the dose-ranging studies (n = 86), patients received either CP-122,721 100 mg (vs. placebo) or 200 mg (vs. placebo) orally 60-90 min before indu

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12

Muralinath, E., Devi Pooja, Chbukdhara Prasanta, et al. "Exploring the Mechanisms of Action of Anti emetic Drugs." Journal of Advancement in Immunology 1, no. 1 (2024): 26–28. https://doi.org/10.5281/zenodo.10837409.

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<em>Antiemetic drugs play an important role in managing the distressing symptoms.  Serotonin receptor antagonists namely ondonsetron and granisetron and perform the work by stopping  ( 5 HT 3 ) receptors in the GIT and CNS. Dopamine is related to the sensation of nausea. Drugs like metaclopramide and prochlorperazine behave as Dopamine receptor antagonists. NK/ receptor antagonists namely aperpitant and fosaprepitant influence the action of substance P in the brain. Cannabinoids namely drombinol and nabilone act on these receptors and modulate thecrelease of neurotransmitters precipi

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13

Folch, Christine. "Ceremony, Medicine, Caffeinated Tea: Unearthing the Forgotten Faces of the North American Stimulant Yaupon (Ilex vomitoria)." Comparative Studies in Society and History 63, no. 2 (2021): 464–98. http://dx.doi.org/10.1017/s0010417521000116.

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AbstractYaupon (the unfortunately named Ilex vomitoria) is a holly commonly used as yard décor in the southeast United States, but many North Americans will be surprised to learn that it is the source of a stimulant tea that has been in continuous use for nearly a millennium. Yaupon is more than a drink; it is a window into questions of identity, community belonging, and how the New World was inserted into the global economy. From Cabeza de Vaca's sixteenth-century brush with the beverage, yaupon has iterated between ceremony, medicine, and caffeinated tea as inhabitants of North America—Indig

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14

Lang, Ivan M. "Digestive tract motor correlates of vomiting and nausea." Canadian Journal of Physiology and Pharmacology 68, no. 2 (1990): 242–53. http://dx.doi.org/10.1139/y90-038.

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The digestive tract from the upper esophageal sphincter to the ileum participates in the vomiting process, but the role of the digestive tract in nausea is unclear. In preparation for vomiting, the proximal stomach relaxes and the small intestine is evacuated orad in a single mass movement by a retrograde giant contraction and caudad in a stripping fashion by a series of phasic contractions. Orad evacuation of the small intestine may not only remove offending substances but may also dilute or buffer gastric contents with intestinal and pancreaticobiliary secretions. In association with retchin

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15

Barnett, Chad M., Michael S. Oholendt, Uday Popat, George Carrum, and Helen E. Heslop. "Evaluation of Aprepitant for Treatment of Acute and Delayed Chemotherapy-Induced Nausea and Vomiting in Patients Undergoing Autologous Stem Cell Transplantation." Blood 104, no. 11 (2004): 5041. http://dx.doi.org/10.1182/blood.v104.11.5041.5041.

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Abstract Autologous stem cell transplant (ASCT) requires therapy with very highly emetogenic chemotherapy regimens. Nausea and emesis are a major issue for patients undergoing ASCT. Aprepitant, a selective substance-P/neurokinin 1 (NK1) receptor antagonist, has been approved by the U.S. Food and Drug Administration for treatment of acute and delayed CINV in combination with a corticosteroid and 5-HT3 receptor antagonist. Due to little patient data in this area, a retrospective chart review was performed which evaluated 41 ASCT patients that had received standard therapy (control group, n=25) c

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16

Merlo, Alexandre. "Pharmacological management of vomiting in feline patients – a review." Clínica Veterinária XXV, no. 146 (2020): 72–85. http://dx.doi.org/10.46958/rcv.2020.xxv.n.146.p.72-85.

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Vomiting is a complex protective reflex mediated by the emetic center, a region of the central nervous system that receives impulses from other central and peripheral afferent areas. In cats, substance P, serotonin and norepinephrine are the main mediators of vomiting, with histamine, dopamine, acetylcholine, and enkephalins having a secondary role. In view of variations in the physiology of vomiting and pharmacology across species, the importance of studies focused on felines is emphasized. Among the emetic agents, alpha-2-adrenergic agonists, such as dexmedetomidine and xylazine, are the mos

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17

Matsuki, Norio, Miwa Toyoda, and Hiroshi Saito. "ROLE OF SUBSTANCE P IN EMESIS." Folia Pharmacologica Japonica 108, supplement (1996): 133–38. http://dx.doi.org/10.1254/fpj.108.supplement_133.

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18

Paliy, A. E., and V. D. Rabotyagov. "BIOLOGICALLY ACTIVE SUBSTANCES OF LAVANDULA X INTERMEDIA EMERIC EX LOISEL (LAMIACEAE)." Pharmacy & Pharmacology 4, no. 1(14) (2016): 46–54. http://dx.doi.org/10.19163/2307-9266-2016-4-1(14)-46-54.

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19

Habek, Roko, and Dubravko Habek. ""Medicamenten-Kastens" from 1850." Acta historiae medicinae, stomatologiae, pharmaciae, medicinae veterinariae 43, no. 2 (2024): 29–37. https://doi.org/10.5937/acthist43-53058.

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The paper presents the content of the basic medicine box "Medicamenten-Kastens" from 1850 for military units according to the original document of the Aulic Chancellery in Vienna, with a discussion. It contained 8 utensils for mensuration, dispensing and application of medicinal substances and 28 substances in the form of 22 "simplicia" and 4 "composita" and 2 bases for medicinal preparations. Topical disinfectants and hemostyptics, expectorants, analgo-spasmolytics, emetics, purgatives and digestives from the contents of this mobile military pharmacy were a component of the pharmacopoeias of

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20

Rupniak, Nadia M. J., and Mark S. Kramer. "Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists." Trends in Pharmacological Sciences 20, no. 12 (1999): 485–90. http://dx.doi.org/10.1016/s0165-6147(99)01396-6.

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21

Kuswandi, Nabila Aulia Yasmin, and Yulistiani Yulistiani. "OLANZAPINE FOR NAUSEA AND VOMITING IN VARIOUS ETIOLOGIES : A REVIEW." Pharmaceutical Journal of Indonesia 8, no. 2 (2023): 103–14. http://dx.doi.org/10.21776/ub.pji.2023.008.02.1.

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Nausea is an unpleasant response followed by the risk of vomiting that results rapid forced ejection of gastric substance from the stomach upwards and out of the mouth. The Gastrointestinal tract, vestibular system, and thalamus are the sites that cause this event. Serotonin type 3 (5-HT3), Mu, neurokinin-1 (NK-1), kappa opioids, dopamine type 2 (D2) are CTZ receptors that cause emesis. 5-HT3 antagonists, antihistamines, and phenothiazines are common antiemetic agents. Olanzapine is an atypical antipsychotic second-generation medication with antiemetic properties. This article review used a cl

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22

Loganathan, Priyadarshini, Mahesh Gajendran, and Hemant Goyal. "A Comprehensive Review and Update on Cannabis Hyperemesis Syndrome." Pharmaceuticals 17, no. 11 (2024): 1549. http://dx.doi.org/10.3390/ph17111549.

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Cannabis, derived from Cannabis sativa plants, is a prevalent illicit substance in the United States, containing over 400 chemicals, including 100 cannabinoids, each affecting the body’s organs differently upon ingestion. Cannabis hyperemesis syndrome (CHS) is a gut–brain axis disorder characterized by recurring nausea and vomiting intensified by excessive cannabis consumption. CHS often goes undiagnosed due to inconsistent criteria, subjective symptoms, and similarity to cyclical vomiting syndrome (CVS). Understanding the endocannabinoid system (ECS) and its dual response (pro-emetic at highe

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23

N., Deepa Devi. "Medicinal Values of Trichosanthus cucumerina L. (Snake Gourd) - A Review." British Journal of Pharmaceutical Research 16, no. 5 (2017): 1–10. https://doi.org/10.9734/BJPR/2017/33575.

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Snake gourd is an annual climber and it’s commonly called as snake gourd, viper gourd, snake tomato or long tomato. The fruit is usually consumed as a vegetable due to it is good nutritional value. The fruit is a good source of Vitamin A, Vitamin B and Vitamin C. It improves the appetite and acts as a tonic and stomachic and cures biliousness. This is one of the most genetically diverse groups of food plant in the plant kingdom and every part of this plant is used to treat various diseases. It is used in the treatment of head ache, alopecia, fever, abdominal tumors, bilious, boils, acute colic

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Gerald, M. Higa, Cumpston Aaron, L. Auber Miklos, and Hobbs Gerry. "Further Evidence of an Association Between the Ratio of Substance P to 5-HIAA/Cr and Delayed Chemotherapy-induced Vomiting." Biohelikon 2, no. 1 (2014): 1–5. https://doi.org/10.5281/zenodo.814319.

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Substantial evidence support the role of serotonin and substance P as mediators of chemotherapy-induced vomiting. Preliminary data suggested that the numerical ratio of the two neurotransmitters could be a novel marker associated with delayed emesis. However, because of the small number of subjects and variable treatment regimens in the early report, additional patients were enrolled into the clinical study to determine whether the association persisted in a more homogeneous group of subjects.

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Yang, C., D. Thota, S. Prasad, W. Woo, and L. Abdelghani. "Boerhaave Syndrome From Chronic Emesis and Chronic Substance Abuse." American Journal of Respiratory and Critical Care Medicine 211, Abstracts (2025): A5757. https://doi.org/10.1164/ajrccm.2025.211.abstracts.a5757.

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Osuala Felix N, Innocent Janet Amarachi, and Uchenna E Odoh. "Pharmacognostic screening and antiemetic evaluation of the ethanol extract of the leaves of Morinda lucida benth. (rubiaceae)." World Journal of Biology Pharmacy and Health Sciences 7, no. 3 (2021): 001–14. http://dx.doi.org/10.30574/wjbphs.2021.7.3.0083.

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Emesis is a common side and adverse effect associated with many illnesses, even drugs. It is the act or process of vomiting. Causes vary from pregnancy, morning sickness, motion sickness, chemotherapy and so on. Emetics are drugs or substances that induce vomiting. Antiemetics are agents given to stop vomiting and to stop the nauseous feeling. Morinda lucida, Benth. family, Rubiacae. It is commonly known as brimstone tree. It is about 24m long, the branches are fibrous in nature and does not break easily, the tree bark is brown to grey, the leaves are green with green fruits. This project is f

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Sun, Yina, та Nissar A. Darmani. "A Comparative Study of the Antiemetic Effects of α2-Adrenergic Receptor Agonists Clonidine and Dexmedetomidine against Diverse Emetogens in the Least Shrew (Cryptotis parva) Model of Emesis". International Journal of Molecular Sciences 25, № 9 (2024): 4603. http://dx.doi.org/10.3390/ijms25094603.

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In contrast to cats and dogs, here we report that the α2-adrenergic receptor antagonist yohimbine is emetic and corresponding agonists clonidine and dexmedetomidine behave as antiemetics in the least shrew model of vomiting. Yohimbine (0, 0.5, 0.75, 1, 1.5, 2, and 3 mg/kg, i.p.) caused vomiting in shrews in a bell-shaped and dose-dependent manner, with a maximum frequency (0.85 ± 0.22) at 1 mg/kg, which was accompanied by a key central contribution as indicated by increased expression of c-fos, serotonin and substance P release in the shrew brainstem emetic nuclei. Our comparative study in shr

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Osuala, Felix N., Janet Amarachi Innocent, and E. Odoh Uchenna. "Pharmacognostic screening and antiemetic evaluation of the ethanol extract of the leaves of Morinda lucida benth. (rubiaceae)." World Journal of Biology Pharmacy and Health Sciences 7, no. 3 (2021): 01–014. https://doi.org/10.5281/zenodo.5542959.

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Emesis is a common side and adverse effect associated with many illnesses, even drugs. It is the act or process of vomiting. Causes vary from pregnancy, morning sickness, motion sickness, chemotherapy and so on. Emetics are drugs or substances that induce vomiting. Antiemetics are agents given to stop vomiting and to stop the nauseous feeling. <em>Morinda lucida, </em>Benth. family, Rubiacae. It is commonly known as brimstone tree. It is about 24m long, the branches are fibrous in nature and does not break easily, the tree bark is brown to grey, the leaves are green with green fruits

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29

Vadhan-Raj, Saroj, Ivan Spasojevic, Xiao Zhou, et al. "Effects of Aprepitant on Drug Metabolism in Lymphoma Patients Receiving Multi-Day Chemotherapy Regimen of Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, + Rituxan (R/CHOP): Randomized, Cross-Over Study." Blood 118, no. 21 (2011): 1613. http://dx.doi.org/10.1182/blood.v118.21.1613.1613.

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Abstract Abstract 1613 Chemotherapy-induced nausea and vomiting (CINV) is a frequent adverse event that can impair the quality of life in cancer patients (pts). In pts receiving cyclophosphamide (CP) and doxorubicin-based regimen, the combination of dexamethasone (dexa) and 5-HT3 receptor antagonists (5-HT3 RA) is very effective in acute emesis, however, control of delayed-emesis remains poor. The neurotransmitter substance P appears to be involved in both the acute and delayed-phases. Aprepitant, a substance P/ neurokinin (NK)-1 receptor antagonist, when combined with 5-HT3 RA and dexa, has b

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Autreto, Pedro Alves da Silva, and Francisco Carlos Lavarda. "Febrifugine derivative antimalarial activity: quantum mechanical predictors." Revista do Instituto de Medicina Tropical de São Paulo 50, no. 1 (2008): 21–24. http://dx.doi.org/10.1590/s0036-46652008000100005.

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Plasmodium falciparum resistant strain development has encouraged the search for new antimalarial drugs. Febrifugine is a natural substance with high activity against P. falciparum presenting strong emetic property and liver toxicity, which prevent it from being used as a clinical drug. The search for analogues that could have a better clinical performance is a current topic. We aim to investigate the theoretical electronic structure by means of febrifugine derivative family semi-empirical molecular orbital calculations, seeking the electronic indexes that could help the design of new efficien

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Silva, Joao P., and Felix Carvalho. "The therapeutic use of cannabis and cannabinoids." Revista Española de Drogodependencias 47, no. 4 (2022): 123–41. http://dx.doi.org/10.54108/10032.

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Cannabinoids mainly target the endocannabinoid system, which emerges as a potentially interesting therapeutical target due to its major role in modulating key biological processes throughout the body. As such, cannabinoids have already been proposed as, for example, anti-emetics, antispasticity agents, appetite stimulants, anti-epileptic, analgesic, depressants of intraocular pressure or as agents to control movement disorders in Tourette syndrome. Here, we reviewed the research evidence available regarding the use of cannabis and cannabinoids for a set of suggested therapeutical applications,

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Fukui, Hideo, Takao Ando, and Masaki Yamamoto. "Emetic effects of substance P and neurokinin A and involvement of peripheral NK1 and NK2 receptors in dogs." Japanese Journal of Pharmacology 71 (1996): 111. http://dx.doi.org/10.1016/s0021-5198(19)36685-5.

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Cruz, Felipe Tsuruta Lisboa, Rachel Vicente Silva, Aline Cristina Pereira dos Santos, Allan Rodrigues Coutinho, and Raquel Carvalho Castiglione. "The use of cannabinoids in the treatment of multiple sclerosis." Concilium 23, no. 21 (2023): 219–30. http://dx.doi.org/10.53660/clm-2449-23s43.

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Cannabis sativa is a component of the group of psychotropic cannabinoids and its main active component is tetrahydrocannabinol (THC). Its influence on the medial prefrontal cortex is complex, and its dose-dependency is high. Cannabis sativa is the third most used substance in the world, after cigarettes and alcohol. Currently, it is being used for illegal recreational purposes and medicinal purposes in complementary therapy. Cannabidiol (CBD) can be found in 60 subtypes of Cannabis sativa and has a therapeutic effect, being used to treat various diseases. In patients with multiple sclerosis, i

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Erbangga, Aghnia Rizkihidayati, and Riana Pascawati. "PENGGUNAAN MINUMAN WEDANG JAHE TERHADAP MUAL MUNTAH PADA KEHAMILAN TRIMESTER 1." Jurnal Kesehatan Siliwangi 2, no. 3 (2022): 791–98. http://dx.doi.org/10.34011/jks.v2i3.776.

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Nausea and vomiting occur in 60-80% in primigravida and 40-60% in multigravida. Nausea and vomiting for no apparent reason may be a symptom of early pregnancy, known as emesis gravidarum. Emesis Gravidarum is a symptom of nausea accompanied by vomiting that occurs in early pregnancy. The cause of emesis gravidarum is an increase in the hormones Estrogen, Progesterone and Human Chorionic Gonodothropine (HCG). The purpose of carrying out midwifery care for pregnant women with emesis at UPT Puskesmas Ibrahim Adjie, the content in ginger can block serotonin, a neurotransmitter that is synthesized

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GREENSHER, JOSEPH, HOWARD C. MOFENSON, and THOMAS R. CARACCIO. "Ascendancy of the `Black Bottle'." Pediatrics 82, no. 3 (1988): 522–23. http://dx.doi.org/10.1542/peds.82.3.522.

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In Reply.— It was not our intent to undermine confidence in syrup of ipecac as a useful and effective means of inducing emesis when indicated, particularly as a home first aid measure. However, it must be recognized that activated charcoal has definite advantages in inactivating larger quantities of ingested substances particularly in circumstances in which the use of syrup of ipecac would no longer be of great benefit. We pointed out that resistance to acceptance of activated charcoal by children limits present use predominantly to emergency departments where compliance can be assured.

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Bates, Nicola. "Poisons affecting the neurological system." Companion Animal 25, no. 2 (2020): 83–91. http://dx.doi.org/10.12968/coan.2019.0072.

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The brain is susceptible to a variety of poisons. Sedating drugs and chemicals can cause central nervous system (CNS) depression while other substances can cause CNS stimulation, including seizures. These are of particular concern since intractable seizure activity may cause complications, with pyrexia resulting in secondary damage to other organs. The common poisons discussed here that cause neurological effects are metaldehyde and tremorgenic mycotoxins, which can cause rapid onset seizures; cannabis, which can cause prolonged sedation in companion animals; permethrin, which is associated wi

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Bates, Nicola. "Poisons affecting the neurological system." Veterinary Nurse 11, no. 3 (2020): 116–25. http://dx.doi.org/10.12968/vetn.2020.11.3.116.

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The brain is susceptible to a variety of poisons. Sedating drugs and chemicals can cause central nervous system (CNS) depression while other substances can cause CNS stimulation, including seizures. These are of particular concern since intractable seizure activity may cause complications, with pyrexia resulting in secondary damage to other organs. The common poisons discussed here that cause neurological effects are metaldehyde and tremorgenic mycotoxins, which can cause rapid onset seizures; cannabis, which can cause prolonged sedation in companion animals; permethrin, which is associated wi

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Sumiyati, Sumiyati. "Efektifitas Pemberian Terapi Essensial Oil Lemon, Jahe dan Peppermint terhadap Penurunan Ketidaknyamanan Ibu Hamil dengan Emesis Gravidarum." Jurnal Interprofesi Kesehatan Indonesia 3, no. 3 (2024): 570–77. http://dx.doi.org/10.53801/jipki.v3i3.132.

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Introduction: Discomfort in the first trimester of pregnancy is often experienced, one of which is nausea and vomiting, nausea, and vomiting frequently occur due to several causes, including hormonal changes in the body such as an increase in estrogen and HcG hormones. In this condition, treatment can be done by pharmacological or nonpharmacological means. Pharmacological therapy will have side effects on the condition of the mother and fetus. Providing artificial substances (unnatural) has implications for the poor health of the fetus, this is because the fetus is still vulnerable to environm

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Ulas, Arife, Kamile Silay, Sema Akinci, and Bulent Yalcin. "Substance P is a Major Mediator Causing Delayed Emesis in Anthracycline-Based Chemotherapy - Really?" Asian Pacific Journal of Cancer Prevention 15, no. 24 (2015): 10993. http://dx.doi.org/10.7314/apjcp.2014.15.24.10993.

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Nkechinyere Adeniyi, Joy, Manimbulu Nlooto, Mlungisi Ngcobo, Roshila Moodley, and Exnevia Gomo. "Phytochemical profile and in vitro antioxidant activity of Emelia M (EMB), Mshikazi and Delosma H herbal medicines as demonstrated in THP-1 and Jurkat leukaemia cell lines." African Health Sciences 21, no. 4 (2021): 1924–37. http://dx.doi.org/10.4314/ahs.v21i4.51.

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Background: Three decoctions, namely Emelia M (EMB), Mshikazi and Delosma H are used by traditional health practitioners in KwaZulu-Natal, South Africa to treat and manage leukaemia and related conditionsObjectives: This study evaluated the in vitro antioxidant activity and phytochemical profile of the aqueous extracts of Emelia M (EMB), Mshikazi and Delosma H decoctions.Methods: Antioxidant activity of the extracts was evaluated using1-diphenyl-2-picrylhydrazyl (DPPH), glutathione (GSH), phosphomolybdate and thiobarbituric acid reactive substance (TBARS) assays. Phytochemical screening was us

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S.N., Rassokha. "Detrmination of activity effect of Emestim С on the different fases of germination of sead of Pisum sativum L." Plant Introduction 15-16 (1 грудня 2002): 140–45. https://doi.org/10.5281/zenodo.3254894.

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It was carried out investigations genome sensitivity of peas sedlings sort Raport to biostimulin Emistim C. All fases of cell cycles were sensitive to physiological-active substances which composed Emistim C. The action of this influence to confirm the law of Amdt-Schultz and revealed the periodical fallings and upwards of activity peaks.

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Koga, Tomoshipe, and Hiroyuki Fukuda. "250 Possible participation of substance p in transmission from emetic vagal afferents to neurons of the nucleus of the solitary tract in dogs." Neuroscience Research 25 (January 1996): S45. http://dx.doi.org/10.1016/0168-0102(96)88679-2.

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Saito, Ryo, Yukio Takano, and Hiro-o. Kamiya. "Roles of Substance P and NK1 Receptor in the Brainstem in the Development of Emesis." Journal of Pharmacological Sciences 91, no. 2 (2003): 87–94. http://dx.doi.org/10.1254/jphs.91.87.

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Cassoli, Ana A. dos S., Raimundo C. Palheta Jr., and Ricardo Lola Pereira. "Maropitant citrate as an adjunct to visceral analgesia in dogs and cats – review." Clínica Veterinária XXVI, no. 150 (2021): 50–62. http://dx.doi.org/10.46958/rcv.2021.xxvi.n.150.p.50-62.

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Pain is a complex multifactorial experience associated with tissue damage that causes suffering and reduces an animal’s quality of life. Maropitant citrate is a antagonist specific to the NK-1 receptor which selectively inhibits the production of substance P, a mediator involved in the signals responsible for emesis. For this reason, maropitant was initially developed for the treatment of vomiting in dogs and cats. However, substance P also has a role in the neural pathways responsible for the modulation of harmful stimuli involved in nociception and inflammation. Recent research into this rol

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Shoulder, Richard, Joseph Taylor, and Hilary Stiel. "Use of long term aprepitant as a treatment for refractory nausea following oesophageal stent insertion – a case report." Palliative Medicine 36, no. 2 (2021): 395–98. http://dx.doi.org/10.1177/02692163211065276.

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Background: Aprepitant, a substance P neurokinin-1 receptor antagonist, is licenced for the prevention of acute and delayed nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy. Case: A 33 year-old male with metastatic gastro-oesophageal cancer had multiple admissions for refractory nausea and vomiting following insertion of an oesophageal stent. Action: Mechanical issues with the stent, stent removal and central causes were excluded. Multiple anti-emetic agents were trialled in combination and with varying routes of administration without significant sympto

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Yin, Jie, Karen Chapman, Lindsay D. Clark, et al. "Crystal structure of the human NK1 tachykinin receptor." Proceedings of the National Academy of Sciences 115, no. 52 (2018): 13264–69. http://dx.doi.org/10.1073/pnas.1812717115.

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The NK1 tachykinin G-protein–coupled receptor (GPCR) binds substance P, the first neuropeptide to be discovered in mammals. Through activation of NK1R, substance P modulates a wide variety of physiological and disease processes including nociception, inflammation, and depression. Human NK1R (hNK1R) modulators have shown promise in clinical trials for migraine, depression, and emesis. However, the only currently approved drugs targeting hNK1R are inhibitors for chemotherapy-induced nausea and vomiting (CINV). To better understand the molecular basis of ligand recognition and selectivity, we sol

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ORITO, Kensuke, Asako KAWARAI-SHIMAMURA, Atsushi OGAWA, and Atsushi NAKAMURA. "Safety and efficacy of intravenous administration for tranexamic acid-induced emesis in dogs with accidental ingestion of foreign substances." Journal of Veterinary Medical Science 79, no. 12 (2017): 1978–82. http://dx.doi.org/10.1292/jvms.17-0463.

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Garcia-Recio, Susana, and Pedro Gascón. "Biological and Pharmacological Aspects of the NK1-Receptor." BioMed Research International 2015 (2015): 1–14. http://dx.doi.org/10.1155/2015/495704.

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The neurokinin 1 receptor (NK-1R) is the main receptor for the tachykinin family of peptides. Substance P (SP) is the major mammalian ligand and the one with the highest affinity. SP is associated with multiple processes: hematopoiesis, wound healing, microvasculature permeability, neurogenic inflammation, leukocyte trafficking, and cell survival. It is also considered a mitogen, and it has been associated with tumorigenesis and metastasis. Tachykinins and their receptors are widely expressed in various human systems such as the nervous, cardiovascular, genitourinary, and immune system. Partic

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Cirrik, Selma, Eli Dogan, Ali Aslan, and Ni Tasci. "The effect of aprepitant, a neurokinin-1 receptor antagonist, on epileptiform activity in the penicillin model of epilepsy." Medicine Science | International Medical Journal 13, no. 2 (2024): 284. http://dx.doi.org/10.5455/medscience.2024.01.05.

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Substance P (SP) is a peptide neurotransmitter that plays a role in pain transmission, stress, inflammation, and emesis through neurokinin-1 receptor (NK-1R). Previous studies of NK-1R antagonists suggest that SP can have either convulsant or anticonvulsant effects. Aprepitant, an NK-1R antagonist, is clinically used to prevent nausea and vomiting in chemotherapy and post-operative patients. However, the effects of aprepitant on epilepsy have not been studied yet. Therefore, the objective of this study was to explore the influence of aprepitant on epileptiform activity in a rat model of epilep

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SU, YI-CHENG, and AMY C. LEE WONG. "Detection of Staphylococcal Enterotoxin H by an Enzyme-Linked Immunosorbent Assay." Journal of Food Protection 59, no. 3 (1996): 327–30. http://dx.doi.org/10.4315/0362-028x-59.3.327.

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A double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) was developed for the detection of a newly identified staphylococcal enterotoxin H (SEH). Peroxidase was conjugated to antibodies specific to the enterotoxin. 2,2′ Azino-bis(3-ethylbenz-thiazoline-6-sulfonic acid)(ABTS) in hydrogen peroxide solution was used as the enzyme substrate. A standard curve of purified SEH was prepared with concentrations ranging from 1.3 to 50 ng/ml. SEH at levels equal to 2.5 ng/ml and higher were detected by this procedure. Culture supernatant from the growth of selected Staphylococcus aureus stra

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