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1

Wang, Shanshan, and Joe Wiart. "Sensor-Aided EMF Exposure Assessments in an Urban Environment Using Artificial Neural Networks." International Journal of Environmental Research and Public Health 17, no. 9 (2020): 3052. http://dx.doi.org/10.3390/ijerph17093052.

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This paper studies the time and space mapping of the electromagnetic field (EMF) exposure induced by cellular base station antennas (BSA) using artificial neural networks (ANN). The reconstructed EMF exposure map (EEM) in urban environment is obtained by using data from EMF sensor networks, drive testing and information accessible in a public database, e.g., locations and orientations of BSA. The performance of EEM is compared with Exposure Reference Map (ERM) based on simulations, in which parametric path loss models are used to reflect the complexity of urban cities. Then, a new hybrid ANN,
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2

Jabeur, Randa, and Alaa Alaerjan. "Improving Monitoring of Indoor RF-EMF Exposure Using IoT-Embedded Sensors and Kriging Techniques." Sensors 24, no. 23 (2024): 7849. https://doi.org/10.3390/s24237849.

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Distributed wireless sensor networks (WSNs) are widely used to enhance the quality and safety of various applications. These networks consist of numerous sensor nodes, often deployed in challenging terrains where maintenance is difficult. Efficient monitoring approaches are essential to maximize the functionality and lifespan of each sensor node, thereby improving the overall performance of the WSN. In this study, we propose a method to efficiently monitor radiofrequency electromagnetic fields (RF-EMF) exposure using WSNs. Our approach leverages sensor nodes to provide real-time measurements,
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Seo, Myung-Soon, Jae-Wook Choi, Kyung-Hee Kim, and Hyung-Do Choi. "The Relationship between Risk Perception of Cell Phones and Objective Knowledge of EMF in Korea." International Journal of Environmental Research and Public Health 17, no. 19 (2020): 7207. http://dx.doi.org/10.3390/ijerph17197207.

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This study examines differences between the level of objective knowledge regarding radio-frequency electromagnetic fields (RF-EMF) and risk perception of cell phones in Korea. We also investigate the extent to which socio-demographic factors, perceived EMF exposure, objective knowledge regarding EMF, and psychological factors influence the risk perception of cell phones using hierarchical multiple regression. All 3393 study subjects completed a survey measuring the degree of risk perception of EMF. They were sampled in accordance with representative proportions of sex, age group, and region of
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Iyangui, Nadine Nicole Ndonghan, Sylvestre Biffot, Igor Ndong, and Christian Ekogha. "Spatial Exposure of EMF from Phone Base Stations in the North of Libreville, Gabon." East African Journal of Health and Science 7, no. 2 (2024): 84–95. https://doi.org/10.37284/eajhs.7.2.2472.

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The electromagnetic environment became dense with the spread of its artificial sources in urban and rural areas. More and more publications are describing their unfavourable effects, including human well-being deterioration, disruption of the nervous system functions or cancer occurrence. Also, there is a legal loophole related to electromagnetic fields (EMF) in many countries. The aim of this contribution is to map people's exposure to EMF from phone base stations in the north of Libreville, Gabon. Data on phone base station emissions have been collected with Spectran 6080HF, processed with M
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Yuninda Triyatne, Ardian Nurarifin, Sonata Mahardika, Umar Hamzah, and Diyajeng Luluk Karlina. "Studi Medan Elektromagnetik pada Pembangkit Listrik Tenaga Surya." Jupiter: Publikasi Ilmu Keteknikan Industri, Teknik Elektro dan Informatika 2, no. 6 (2024): 15–21. http://dx.doi.org/10.61132/jupiter.v2i6.609.

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This research investigates the electromagnetic field (EMF) characteristics generated by solar power plants, focusing on their potential environmental and health impacts. The study employs a dual methodology combining direct measurements using gaussmeters and computer simulations using COMSOL software to map electromagnetic fields around solar power installation components. Measurements were taken under two conditions: during solar power plant operation and non-operation, to establish comparative baseline data. The research found significant variations in electromagnetic field intensity based o
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Gonzalez-Rubio, Jesus, Alberto Najera, and Enrique Arribas. "Comprehensive personal RF-EMF exposure map and its potential use in epidemiological studies." Environmental Research 149 (August 2016): 105–12. http://dx.doi.org/10.1016/j.envres.2016.05.010.

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7

Nájera, Alberto, Rocío Sánchez-Montero, Jesús González-Rubio, Jorge Guillén-Pina, Ricardo Chocano-del-Cerro, and Pablo-Luis López-Espí. "Comparison Between Broadband and Personal Exposimeter Measurements for EMF Exposure Map Development Using Evolutionary Programming." Applied Sciences 15, no. 13 (2025): 7471. https://doi.org/10.3390/app15137471.

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In this study, we provide a comparison of radiofrequency electromagnetic field exposure level maps as determined using two approaches: a broadband meter (NARDA EMR-300) equipped with an isotropic probe in the range of 100 kHz to 3 GHz, and a Personal Exposimeter (Satimo EME Spy 140) in the range of 88 MHz to 5.8 GHz. The aim of this research was to determine the necessary adjustments to the measurements made with personal exposimeters to obtain RF-EMF exposure maps equivalent to those made with broadband meters. We evaluated different possibilities to obtain the best equivalence of measurement
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8

Laganà, Filippo, Danilo Prattico, Domenico De Carlo, Giuseppe Oliva, Salvatore A. Pullano, and Salvatore Calcagno. "Engineering Biomedical Problems to Detect Carcinomas: A Tomographic Impedance Approach." Eng 5, no. 3 (2024): 1594–614. http://dx.doi.org/10.3390/eng5030084.

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Computed tomography (CT), magnetic resonance imaging (MRI), and radiography expose patients to electromagnetic fields (EMFs) and ionizing radiation. As an alternative, Electrical Impedance Tomography (EIT) offers a less EMF-influenced method for imaging by measuring superficial skin currents to provide a map of the body’s conductivity. EIT allows for functional monitoring of anatomical regions using low electromagnetic fields and minimal exposure times. This paper investigates the application of EIT for the morphological and functional assessment of tissues. Using the Finite Element Method (FE
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9

Pang, L., S. J. Decker, and A. R. Saltiel. "Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells." Biochemical Journal 289, no. 1 (1993): 283–87. http://dx.doi.org/10.1042/bj2890283.

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Both bombesin and epidermal growth factor (EGF) are potent mitogens in Swiss 3T3 cells that nonetheless have dissimilar receptor structures. To explore possible common intracellular events involved in the stimulation of cellular growth by these two peptides, we have evaluated the regulation of the mitogen-activated protein (MAP) kinase. Exposure of Swiss 3T3 cells to bombesin, EGF or the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) causes the rapid and transient stimulation of the enzyme activity. Pretreatment of cells with the protein kinase inhibitor H-7, or down-regulati
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10

Georgiou, Christos D., Electra Kalaitzopoulou, Marianna Skipitari, et al. "Physical Differences between Man-Made and Cosmic Microwave Electromagnetic Radiation and Their Exposure Limits, and Radiofrequencies as Generators of Biotoxic Free Radicals." Radiation 2, no. 4 (2022): 285–302. http://dx.doi.org/10.3390/radiation2040022.

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The critical arguments for radiofrequency radiation exposure limits are currently based on the principle that radio frequencies (RF) and electromagnetic fields (EMFs) are non-ionising, and their exposure limits are even 100-fold lower than those emitted from the Sun in the whole RF-EMF spectrum. Nonetheless, this argument has been challenged by numerous experimental and theoretical studies on the diverse biological effects of RF-EMF at much lower power density (W/m2) levels than today’s exposing limits. On the other hand, less attention has been given to counterarguments based on the differenc
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11

Kelleher, M. D., M. K. Abe, T. S. Chao, et al. "Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis." American Journal of Physiology-Lung Cellular and Molecular Physiology 268, no. 6 (1995): L894—L901. http://dx.doi.org/10.1152/ajplung.1995.268.6.l894.

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Abnormal growth of airway smooth muscle may play an important role in the pathogenesis of human airway diseases. Little is known about the proliferative responses of cultured airway smooth muscle cells, nor of the precise pathways responsible for mitogenesis in these cells. We assessed DNA synthesis, cell proliferation, and mitogen-activated protein (MAP) kinase activation in bovine tracheal myocytes after exposure to four potential mitogens: platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1), and 5-hydroxytryptamine (5-HT). Stimulation w
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12

Gökmen, Uğur, Zübeyde Özkan, and Sema Bilge Ocak. "Impact of the gamma and neutron attenuation behaviors on the functionally graded composite materials." Physica Scripta 96, no. 12 (2021): 125326. http://dx.doi.org/10.1088/1402-4896/ac41ef.

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Abstract Gamma-ray and neutron shielding properties of the AA6082 + TiO2 (0–50 wt%) functionally graded composite materials (FGCMs) were investigated using the PSD software. The values of the mean free path (MFP), half-value layer (HVL), linear attenuation coefficients (LAC), mass attenuation coefficient (MAC), tenth-value layer (TVL), exposure buildup factors (EBF), effective atomic number (Z eff ), effective conductivity (C eff ), and fast neutron removal cross-sections (FNRC) were found for the energy range between 0.015–15 MeV. The increase in the TiO2 content in the AA6082 composite mater
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13

Heasley, L. E., S. I. Senkfor, S. Winitz, A. Strasheim, I. Teitelbaum, and T. Berl. "Hormonal regulation of MAP kinase in cultured rat inner medullary collecting tubule cells." American Journal of Physiology-Renal Physiology 267, no. 3 (1994): F366—F373. http://dx.doi.org/10.1152/ajprenal.1994.267.3.f366.

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Mitogen-activated protein (MAP) kinase is a widely expressed protein serine/threonine kinase that serves as a convergence point for many signaling pathways including receptor tyrosine kinases, G protein-coupled receptors, and protein kinase C (PKC). The hormonal regulation of MAP kinase was studied in cultured established rat inner medullary collecting tubule (RIMCT) cells. Neither vasopressin nor beta-adrenergic agonists stimulated MAP kinase, despite clear stimulation of adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase. In contrast, carbachol, ATP, and epidermal growth fa
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14

Bevington, Michael. "The Prevalence of People With Restricted Access to Work in Man-Made Electromagnetic Environments." Journal of Environment and Health Science 5, no. 1 (2019): 1–12. http://dx.doi.org/10.15436/2378-6841.19.2402.

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Some surveys have identified people who have restricted access to work in environments with man-made electromagnetic exposures. This study attempts to determine their prevalence, an aspect not previously investigated in its own right. It is based on analyses of the two different types of surveys of people with Idiopathic Environmental Intolerance attributed to Electromagnetic Fields (IEI-EMF), or Electromagnetic Hyper-Sensitivity (EHS), either of the general population or of people with IEI-EMF/EHS. In addition, there are different definitions of IEI-EMF/EHS, with a range of subconscious, mild
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15

Lee, M., C. Hwang, J. Lee, H. Slavkin, and D. Warburton. "TGF-beta isoforms differentially attenuate EGF mitogenicity and receptor activity in fetal lung mesenchymal cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 273, no. 2 (1997): L374—L381. http://dx.doi.org/10.1152/ajplung.1997.273.2.l374.

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To evaluate signaling interactions, combinations of epidermal growth factor (EGF) and transforming growth factor-beta (TGF-beta) isoforms were applied to primary fetal mouse lung mesenchymal cells isolated at 16 days of gestation. The three isoforms of TGF-beta had similar mitogenic potentials, as assessed by thymidine incorporation (half-maximal effective concentration approximately 2 ng/ml). However, combined exposure to EGF and TGF-beta yielded an isoform-dependent attenuation of EGF-induced mitogenesis. Combinations of 20 ng/ml EGF and 2 ng TGF-beta 1, TGF-beta 2, or TGF-beta 3 resulted in
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16

SUDBECK, Barry D., Petra BAUMANN, Gavin J. RYAN, et al. "Selective loss of PMA-stimulated expression of matrix metalloproteinase 1 in HaCaT keratinocytes is correlated with the inability to induce mitogen-activated protein family kinases." Biochemical Journal 339, no. 1 (1999): 167–75. http://dx.doi.org/10.1042/bj3390167.

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Many cell types, including fibroblasts and primary keratinocytes, increase matrix metalloproteinase 1 (MMP-1) production in response to agonists such as growth factors and phorbol esters. However, the spontaneously transformed human keratinocyte cell line HaCaT, although it increases MMP-1 production in response to epidermal growth factor (EGF), does not respond similarly to stimulation with PMA. This phenomenon occurs even though HaCaT cells remain proliferatively responsive to both agonists, suggesting a HaCaT-specific defect in a PMA-mediated signal transduction pathway. Using an inside-out
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17

Gosens, Reinoud, Gordon Dueck, William T. Gerthoffer, et al. "p42/p44 MAP kinase activation is localized to caveolae-free membrane domains in airway smooth muscle." American Journal of Physiology-Lung Cellular and Molecular Physiology 292, no. 5 (2007): L1163—L1172. http://dx.doi.org/10.1152/ajplung.00471.2006.

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Caveolae are abundant plasma membrane invaginations in airway smooth muscle that may function as preorganized signalosomes by sequestering and regulating proteins that control cell proliferation, including receptor tyrosine kinases (RTKs) and their signaling effectors. We previously demonstrated, however, that p42/p44 MAP kinase, a critical effector for cell proliferation, does not colocalize with RTKs in caveolae of quiescent airway myocytes. Therefore, we investigated the subcellular sites of growth factor-induced MAP kinase activation. In quiescent myocytes, though epidermal growth factor r
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18

Grubbs, R. D. "Effect of epidermal growth factor on magnesium homeostasis in BC3H1 myocytes." American Journal of Physiology-Cell Physiology 260, no. 6 (1991): C1158—C1164. http://dx.doi.org/10.1152/ajpcell.1991.260.6.c1158.

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The acute effects of epidermal growth factor (EGF) on Mg2+ homeostasis were studied in differentiated BC3H1 myocytes. EGF produced a 48-fold stimulation of [3H]thymidine incorporation into quiescent serum-starved cells in the presence of Mg2+, whereas insulin had no effect on [3H]thymidine incorporation. The dose dependence of EGF-stimulated [3H]thymidine incorporation was similar to that of EGF stimulation of 28Mg2+ uptake. In cells loaded with the Mg(2+)-sensitive fluorescent indicator, Mag-fura-2, intracellular Mg2+ concentration ([Mg2+]i) increased after exposure to EGF after a 5-min lag;
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19

Larrivée, Jean-François, Dimcho R. Bachvarov, François Houle, Jacques Landry, Jacques Huot, and François Marceau. "Role of the Mitogen-Activated Protein Kinases in the Expression of the Kinin B1 Receptors Induced by Tissue Injury." Journal of Immunology 160, no. 3 (1998): 1419–26. http://dx.doi.org/10.4049/jimmunol.160.3.1419.

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Abstract Several cytokines and LPS regulate the population of the B1 receptors (B1Rs) for kinins; these are responsive to des-Arg9-bradykinin (BK) and Lys-des-Arg9-BK. B1R activation contributes to inflammatory vascular changes and pain. Aortic rings isolated from normal rabbits and incubated in vitro in Krebs physiological medium were used as a model of tissue injury. From a null level of response, these rings exhibit a time- and protein synthesis-dependent increase in the maximal contractile response to des-Arg9-BK. Exposure to exogenous IL-1β or epidermal growth factor (EGF) considerably in
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20

Chen, P., H. Xie, M. C. Sekar, K. Gupta, and A. Wells. "Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement." Journal of Cell Biology 127, no. 3 (1994): 847–57. http://dx.doi.org/10.1083/jcb.127.3.847.

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We recently have demonstrated that EGF receptor (EGFR)-induced cell motility requires receptor kinase activity and autophosphorylation (P. Chen, K. Gupta, and A. Wells. 1994. J. Cell Biol. 124:547-555). This suggests that the immediate downstream effector molecule contains a src homology-2 domain. Phospholipase C gamma (PLC gamma) is among the candidate transducers of this signal because of its potential roles in modulating cytoskeletal dynamics. We utilized signaling-restricted EGFR mutants expressed in receptor devoid NR6 cells to determine if PLC activation is necessary for EGFR-mediated ce
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21

Heasley, L. E., and G. L. Johnson. "The beta-PDGF receptor induces neuronal differentiation of PC12 cells." Molecular Biology of the Cell 3, no. 5 (1992): 545–53. http://dx.doi.org/10.1091/mbc.3.5.545.

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Expression of the mouse beta-PDGF receptor by gene transfer confers PDGF-dependent and reversible neuronal differentiation of PC12 pheochromocytoma cells similar to that observed in response to NGF and basic FGF. A common property of the PDGF, NGF, and basic FGF-induced differentiation response is the requirement for constant exposure of cells to the growth factor. To test the hypothesis that a persistent level of growth factor receptor signaling is required for the maintenance of the neuronal phenotype, we examined the regulation of the serine/threonine-specific MAP kinases after either short
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22

Falin, Rebecca, I. Elias Veizis, and Calvin U. Cotton. "A role for ERK1/2 in EGF- and ATP-dependent regulation of amiloride-sensitive sodium absorption." American Journal of Physiology-Cell Physiology 288, no. 5 (2005): C1003—C1011. http://dx.doi.org/10.1152/ajpcell.00213.2004.

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Receptor-mediated inhibition of amiloride-sensitive sodium absorption was observed in primary and immortalized murine renal collecting duct cell (mCT12) monolayers. The addition of epidermal growth factor (EGF) to the basolateral bathing solution of polarized monolayers reduced amiloride-sensitive short-circuit current ( Isc) by 15–25%, whereas the addition of ATP to the apical bathing solution decreased Isc by 40–60%. Direct activation of PKC with phorbol 12-myristate 13-acetate (PMA) and mobilization of intracellular calcium with 2,5-di- tert-butyl-hydroquinone (DBHQ) reduced amiloride-sensi
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23

Liu, W., A. A. Akhand, M. Kato, et al. "4-hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition." Journal of Cell Science 112, no. 14 (1999): 2409–17. http://dx.doi.org/10.1242/jcs.112.14.2409.

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Lipid peroxidation has been implicated in the pathogenesis of various diseases. As a major product of membrane lipid peroxidation, 4-hydroxynonenal (HNE) appears after various kinds of oxidative stress, and is known to induce cell growth inhibition. We here analysed the HNE-mediated signal transduction cascade for the growth inhibition of human epidermoid carcinoma A431 cells. HNE dose-dependently induced phosphorylation of multiple cellular proteins including epidermal growth factor receptor (EGFR) in A431 cells, and rapidly upregulated the catalytic actions of EGFR for autophosphorylation an
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24

Gibbons, Don L., Anna Ahn, Maofu Liao, Lena Hammar, R. Holland Cheng, and Margaret Kielian. "Multistep Regulation of Membrane Insertion of the Fusion Peptide of Semliki Forest Virus." Journal of Virology 78, no. 7 (2004): 3312–18. http://dx.doi.org/10.1128/jvi.78.7.3312-3318.2004.

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ABSTRACT A prevailing model for virus membrane fusion proteins has been that the hydrophobic fusion peptide is hidden in the prefusion conformation, becomes exposed once the fusion reaction is triggered, and then either inserts into target membranes or is rapidly inactivated. This model is in general agreement with the structure and mechanism of class I fusion proteins, such as the influenza virus hemagglutinin. We here describe studies of the class II fusion protein E1 from the alphavirus Semliki Forest virus (SFV). SFV fusion is triggered by low pH, which releases E1 from its heterodimeric i
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25

Mehta, Rajendra G. "Functional Significance of Selective Expression of ERα and ERβ in Mammary Gland Organ Culture". International Journal of Molecular Sciences 22, № 23 (2021): 13151. http://dx.doi.org/10.3390/ijms222313151.

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Thoracic pair of mammary glands from steroid hormone-pretreated mice respond to hormones structurally and functionally in organ culture. A short exposure of glands for 24 h to 7,12 Dimethylbenz(a)anthracene (DMBA) during a 24-day culture period induced alveolar or ductal lesions. Methods: To differentiate the functional significance of ERα and ERβ, we employed estrogen receptor (ER) knockout mice. We compared the effects of DMBA on the development of preneoplastic lesions in the glands in the absence of ERα (αERKO) and ERβ (βERKO) using an MMOC protocol. Glands were also subjected to microarra
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26

Ehab, Mohamed, Elsayed Salama, Ahmed Ashour, Mohamed Attallah, and Hosam M. Saleh. "Optical Properties and Gamma Radiation Shielding Capability of Transparent Barium Borosilicate Glass Composite." Sustainability 14, no. 20 (2022): 13298. http://dx.doi.org/10.3390/su142013298.

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In this study, both radiation shielding capability and optical properties of prepared SiO2-ZnO-Na2CO3-H3BO3-BaCO3 glass composite with different concentrations of barium carbonate (0–30 mol%) have been studied. Gamma attenuation properties, such as the mass attenuation coefficient (MAC), mean free path (MFP), and exposure build-up factor (EBF), are experimentally and theoretically investigated. The detected XRD patterns for the prepared glass composites confirm their amorphous nature. It is evident from the obtained data that all tested parameters, such as mass density, molar volume, refractiv
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27

Yuan, Ze, Shuai Wang, Chunguang Wang, et al. "Research on Calf Behavior Recognition Based on Improved Lightweight YOLOv8 in Farming Scenarios." Animals 15, no. 6 (2025): 898. https://doi.org/10.3390/ani15060898.

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In order to achieve accurate and efficient recognition of calf behavior in complex scenes such as cow overlapping, occlusion, and different light and occlusion levels, this experiment adopts the method of improving the YOLO v8 model to recognize calf behavior. A calf daily behavior dataset containing 2918 images is selected as the test benchmark through video frame extraction; a P2 small-target detection layer is introduced to improve the resolution of the input scene, which significantly improves the model recognition accuracy, and reduces the computational complexity and storage requirements
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Ezzeldien, M., M. A. Salamab, M. F. Hasaneen, et al. "Multicomponent Ge-As-Te-Pb chalcogenide glasses for radiations shielding applications." Chalcogenide Letters 19, no. 12 (2022): 939. http://dx.doi.org/10.15251/cl.2022.1912.939.

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Phy-X/PSD online program is used to obtain various radiation shielding indices in a photon energy region located between 0.15 and 15 MeV for Ge25-As10-Te65-x-Pbx (x = 2, 4, 6, 8, 10 at %) chalcogenide glasses. The linear attenuation coefficient LAC, mass attenuation coefficients MAC, effective atomic number Zeff, effective electron density Neff, half-value layer, HVL, tenth value layer TVL, mean free path MEF, energy absorption and exposure buildup factors (EABF, EBF), and fast neutron cross section FNRCS have been introduced. The findings conclude that the LAC and MAC measurements are greater
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29

Algethami, Merfat, Awad A. Ibraheem, Shams A. M. Issa, et al. "A Comprehensive Evaluation of the Attenuation Characteristics of Some Sliding Bearing Alloys under 0.015–15 MeV Gamma-Ray Exposure." Materials 15, no. 7 (2022): 2464. http://dx.doi.org/10.3390/ma15072464.

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In this study, three different sliding bearing alloy samples were investigated in terms of their performance on attenuation characteristics and behavioral attitudes under 0.015–15 MeV gamma-ray exposure. Accordingly, different types of advanced calculation methods were utilized to calculate the radiation shielding parameters. Next, several gamma-ray shielding parameters and exposure rates in addition to fast neutron removal cross-section were determined. Furthermore, exposure and energy absorption buildup factors were determined by using G-P fitting method. Mass attenuation coefficients (MAC)
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Ghazal, Ayman Abu, Rawand Alakash, Zainab Aljumaili, Ahmed El-Sayed, and Hamza Abdel-Rahman. "Enhancing Gamma-Neutron Shielding Effectiveness of Polyvinylidene Fluoride for Potent Applications in Nuclear Industries: A Study on the Impact of Tungsten Carbide, Trioxide, and Disulfide Using EpiXS, Phy-X/PSD, and MCNP5 Code." Journal of Radiation Protection and Research 48, no. 4 (2023): 184–96. http://dx.doi.org/10.14407/jrpr.2023.00213.

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Background: Radiation protection is crucial in various fields due to the harmful effects of radiation. Shielding is used to reduce radiation exposure, but gamma radiation poses challenges due to its high energy and penetration capabilities.Materials and Methods: This work investigates the radiation shielding properties of polyvinylidene fluoride (PVDF) samples containing different weight fraction of tungsten carbide (WC), tungsten trioxide (WO<sub>3</sub>), and tungsten disulfide (WS<sub>2</sub>). Parameters such as the mass attenuation coefficient (MAC), half-value lay
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31

Fei, Xing, Chen Nan, You Zheng, and Sun Ting. "A Novel Approach Based on MEMS-Gyro's Data Deep Coupling for Determining the Centroid of Star Spot." Mathematical Problems in Engineering 2012 (2012): 1–20. http://dx.doi.org/10.1155/2012/403584.

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The traditional approach of star tracker for determining the centroid of spot requires enough energy and good shape, so a relatively long exposure time and stable three-axis state become necessary conditions to maintain high accuracy, these limit its update rate and dynamic performance. In view of these issues, this paper presents an approach for determining the centroid of star spot which based on MEMS-Gyro's data deep coupling, it achieves the deep fusion of the data of star tracker and MEMS-Gyro at star map level through the introduction of EKF. The trajectory predicted by using the angular
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32

Rubino, Christopher M., Lukas Stulik, Harald Rouha, et al. "1388. Dose Discrimination for ASN100: Bridging from Rabbit Survival Data to Predicted Activity in Humans Using a Minimal Physiologically Based Pharmacokinetic (mPBPK) Model." Open Forum Infectious Diseases 5, suppl_1 (2018): S426. http://dx.doi.org/10.1093/ofid/ofy210.1219.

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Abstract Background ASN100 is a combination of two co-administered fully human monoclonal antibodies (mAbs), ASN-1 and ASN-2, that together neutralize the six cytotoxins critical to S. aureus pneumonia pathogenesis. ASN100 is in development for prevention of S. aureus pneumonia in mechanically ventilated patients. A pharmacometric approach to dose discrimination in humans was taken in order to bridge from dose-ranging, survival studies in rabbits to anticipated human exposures using a mPBPK model derived from data from rabbits (infected and noninfected) and noninfected humans [IDWeek 2017, Pos
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Horváthová, Martina, Zuzana Bárdyová, Darina Budošová, and Rastislav Husťak. "Impact of methodical guidelines of gastric scintigraphy on patients’ radiation exposure." Gastroenterologie a hepatologie 75, no. 2 (2021): 159–64. http://dx.doi.org/10.48095/ccgh2021159.

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Introduction: Gastric emptying scintigraphy (GES) is a safe, noninvasive method for assessing the ability of the stomach to empty which has been used clinically for many years. It is considered as a “gold standard” to assess gastric emptying of both solids and liquids allowing assessment of early, mid and late emptying, each of which may be altered by pathology. The aim of the study was to analyse standard diagnostic approach and evaluate patients` radiation exposure, who underwent GES in Slovakia. Methods: A retrospective cohort study included 55 patients from 2 departments of nuclear medicin
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Elsafi, Mohamed, M. F. Alrashedi, M. I. Sayyed, et al. "The Potentials of Egyptian and Indian Granites for Protection of Ionizing Radiation." Materials 14, no. 14 (2021): 3928. http://dx.doi.org/10.3390/ma14143928.

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This paper aims to study the radiation shielding characteristics and buildup factor of some types of granite in Egypt. The mass attenuation coefficient (MAC) for three types of granite (gandola, white halayeb, and red aswani) was experimentally determined, and the experimental results were validated by XCOM software. The relative deviation between the two methods does not exceed 3% in all discussed granite samples, which means that MAC calculated through the experimental and XCOM are in suitable agreement. The effective atomic number (Zeff) varies from 13.64 to 10.69, 13.68 to 10.59, and 13.45
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35

El-Qahtani, Z. M. H., E. R. Shaaban, and M. M. Soraya. "Attenuation characteristics of high-energy radiation on As-Se-Sn chalcogenide glassy alloy." Chalcogenide Letters 18, no. 6 (2021): 311–26. http://dx.doi.org/10.15251/cl.2021.186.311.

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The present work is mainly interested in the use of chalcogenide glass materials as shielding materials for the highly energetic radiations as X-rays and Gamma rays and particles of high energies as neutrons. The chalcogenide glass system concerned with this study is As40-Se60-x-Snx (x = 0, 5, 10, 15, 20 at %). Numerous radiation shielding factors have been deduced by the aid of Phy-X/PSD online software. This software enabled us to achieve the linear and mass attenuation coefficients (LAC, MAC), effective atomic number Zeff, effective electron density, Neff, half-value layer, HVL, tenth value
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36

Gouda, Mona M., Ahmed M. El-Khatib, Mahmoud I. Abbas, Shoaa Mofleh Al-Balawi, and Mahmoud T. Alabsy. "Gamma Attenuation Features of White Cement Mortars Reinforced by Micro/Nano Bi2O3 Particles." Materials 16, no. 4 (2023): 1580. http://dx.doi.org/10.3390/ma16041580.

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This study aims to explore the radiation protection properties of white mortars based on white cement as a binder and Bi2O3 micro and nanoparticles in proportions of 15 and 30% by weight as replacement sand. The average particle size of micro- and nano-Bi2O3 was measured using a transmission electron microscope (TEM). The cross-sectional morphology and distribution of Bi2O3 within the samples can be obtained by scanning electron microscopy (SEM), showing that nanoscale Bi2O3 particles have a more homogeneous distribution within the samples than microscale Bi2O3 particles. The shielding paramet
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37

Zahran, Heba Y., El Sayed Yousef, Mohammed S. Alqahtani, et al. "Analysis of the Radiation Attenuation Parameters of Cu2HgI4, Ag2HgI4, and (Cu/Ag/Hg I) Semiconductor Compounds." Crystals 12, no. 2 (2022): 276. http://dx.doi.org/10.3390/cryst12020276.

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This analysis aims to determine photon attenuation for five different ternary and binary iodide compounds using Phy-X/PSD software. For a broad range of photon energies between 0.015 and 15 MeV, the mass attenuation coefficient (MAC), linear attenuation coefficient (LAC), half-value layer (HVL), tenth-value layer (TVL), and mean free path (MFP) for the samples of Cu2HgI4, Ag2HgI4, CuI, AgI, and HgI were calculated. For illustration, the following values of TVL apply at 1 MeV: S1: 6.062 cm, S2: 6.209 cm, S3: 6.929 cm, S4: 6.897 cm, and S5: 4.568 cm. Some important parameters, such as total atom
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38

Anelechi, Madubuike Stella, Mailafia Samuel Egwu O. Godwin, Olabode H. Olatunde, Momoh A.Habiba, Ode O. Julius, and Ramon-Yusuf S.Babatunde. "Phenotypic Identification of Citrobacter Isolates from Cloacal Swabs of Apparently Healthy Turtles at the River Banks in Lokoja, Kogi State, Nigeria." International Journal of Current Microbiology and Applied Sciences 11, no. 11 (2022): 117–25. http://dx.doi.org/10.20546/ijcmas.2022.1111.014.

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Citrobacter species are opportunistic pathogens in humans that can lead to invasive disease, including infections of the urinary tract, respiratory tract, Central Nervous System, skin, and soft tissues. A total of 245 cloacal swab samples were collected from the cloaca of apparently healthy turtles and subjected to conventional biochemical tests. Presumptive identification on MacConkey Agar (MAC) and Xylose lysine deoxycholate agar (XLD) yielded 42.0% (103) on each medium, on Eosin Methylene Blue agar (EMB) yielded 21.6 % (53), and on Salmonella-Shigella agar yielded 9.8% (24) isolates while I
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Poudel, Jeevan, Basanta Subedi, and Tika Ram Lamichhane. "Radiation Shielding Features of Glass Fiber Reinforced Cast Polyamide Using Phy-X/PSD and SRIM Software." Journal of Institute of Science and Technology 28, no. 2 (2023): 71–80. http://dx.doi.org/10.3126/jist.v28i2.55428.

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The utilization of various materials for their nuclear radiation shielding properties has been the subject of a growing number of research and development projects. In this study, the radiation shielding characteristics of E-glass fiber reinforced cast polyamide were evaluated. E-glass is a form of glass fiber frequently utilized as a reinforcement in various composite materials to provide more durability, stiffness, and strength. Samples S1-S7 were defined according to various compositions of E-glass fiber contents (SiO2, Al2O3, B2O3, MgO, CaO, Na2O and K2O) and cast polyamide (C12H22N2O2). W
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40

Saleh, Hosam M., Ibrahim I. Bondouk, Elsayed Salama, Hazem H. Mahmoud, Khalid Omar, and Heba A. Esawii. "Asphaltene or Polyvinylchloride Waste Blended with Cement to Produce a Sustainable Material Used in Nuclear Safety." Sustainability 14, no. 6 (2022): 3525. http://dx.doi.org/10.3390/su14063525.

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The current research uses sustainable methods to preserve the environment, such as exploiting municipal or industrial waste that may harm the environment. The wreckage of polyvinyl chloride (PVC) pipes and asphaltene are used as additives to cement to improve its mechanical properties, while stabilizing the radioactive waste resulting from the peaceful uses of nuclear materials, or enhancing its radiation shielding efficiency. New composites of Portland cement with ground PVC or asphaltene up to 50% are investigated. Fast neutron removal cross-section (ƩR) and gamma shielding parameters, such
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41

Bendell, Johanna C., Kian-Huat Lim, Mark E. Burkard, et al. "CRESTONE: Clinical study of response to seribantumab in tumors with neuregulin-1 (NRG1) fusions—A phase II study of the anti-HER3 mAb for advanced or metastatic solid tumors (NCT04383210)." Journal of Clinical Oncology 39, no. 3_suppl (2021): TPS449. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.tps449.

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TPS449 Background: NRG1 (Neuregulin-1) gene fusions are rare oncogenic drivers found in 0.2% of solid tumors, including lung, pancreatic, gallbladder, breast, ovarian, colorectal, neuroendocrine, and sarcomas. NRG1 is the predominant ligand of HER3 and to a lesser extent HER4. NRG1 fusion proteins retaining an active EGF-like domain drive tumorigenesis and proliferation through aberrant HER3 activation. Importantly, NRG1 fusions are often mutually exclusive with other known driver alterations. NRG1 fusions have been correlated with worse overall and disease-free survival and poor response to t
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Magyarics, Zoltan, Fraser Leslie, Steven A. Luperchio, et al. "Serum and Lung Pharmacokinetics of ASN100, a Monoclonal Antibody Combination for the Prevention and Treatment of Staphylococcus aureus Pneumonia." Open Forum Infectious Diseases 4, suppl_1 (2017): S310. http://dx.doi.org/10.1093/ofid/ofx163.722.

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Abstract Background Monoclonal antibodies (mAbs) are well-suited for the prevention and treatment of acute bacterial infections. ASN100 is a combination of two fully human IgG1 mAbs, ASN-1 and ASN-2 that together neutralize six Staphylococcus aureus cytotoxins, alpha-hemolysin (Hla) and five leukocidins (HlgAB, HlgCB, LukED, LukSF [PVL] and LukGH) that are important in the pathogenesis of S. Aureus pneumonia. We aimed to characterize the pharmacokinetics (PK) of ASN100 in both serum and lung epithelial lining fluid (ELF) in male and female healthy volunteers. Methods The safety, tolerability,
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Takeda, Kotaro, Toshihiro Ichiki, Tomotake Tokunou, Satoshi Fujii, Akira Kitabatake, and Akira Takeshita. "Critical Roles of Rho Kinase and Mek/Erk Pathways for Angiotensin Ii-Induced Plasminogen Activator Inhibitor-1 Gene Expression." Hypertension 36, suppl_1 (2000): 721. http://dx.doi.org/10.1161/hyp.36.suppl_1.721-d.

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P157 Plasminogen activator inhibitor-1 (PAI-1) plays an integral role not only in the regulation of plasminogen activity and fibrinolytic system but also in the pathogenesis of atherosclerosis and hypertension. Because angiotensin II (Ang II) is also involved in these processes, we investigated its role in the intracellular signaling cascade leading to PAI-1 gene expression in vascular smooth muscle cells (VSMC). Ang II increased the PAI-1 mRNA and protein levels through Ang II type 1 receptor. Although PAI-1 mRNA stability was not increased by Ang II, PAI-1 gene promoter activity, which was m
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44

von Achenbach, Caroline, Vincent Blot, William Weiss, and Michael Weller. "CSIG-06. DEPATUXIZUMAB MAFODOTIN (ABT-414)-INDUCED GLIOBLASTOMA CELL DEATH REQUIRES EGFR OVEREXPRESSION, BUT NOT PHOSPHORYLATION." Neuro-Oncology 21, Supplement_6 (2019): vi45. http://dx.doi.org/10.1093/neuonc/noz175.177.

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Abstract Glioblastomas commonly (40%) exhibit epidermal growth factor receptor (EGFR) amplification, half of these tumors carry the EGFRvIII deletion variant characterized by an in-frame deletion of exons 2–7, resulting in constitutive EGFR activation. Although EGFR tyrosine kinase inhibitors had only modest effects in glioblastoma, novel therapeutic agents targeting amplified EGFR or EGFRvIII continue to be developed. Depatuxizumab mafodotin (ABT-414) is an antibody drug conjugate consisting of the monoclonal antibody 806 and, as its toxic payload, monomethyl auristatin F, designed to target
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45

Alharthi, Sami S., and Ali Badawi. "Polymeric Nanocomposites of Polyvinyl Alcohol Embedded with ZnO/CuO/Single-Walled Carbon Nanotubes: Optical and Radiation Shielding Investigations." Polymers 17, no. 6 (2025): 818. https://doi.org/10.3390/polym17060818.

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The optical and radiation shielding of PVA have been enhanced through embedding with ZnO/CuO/SWCNT (ZCS) nanocomposites. ZCS polymeric nanocomposites (PNCs) were prepared with the solution casting method. Scanning electron, optical microscopy and FT-IR procedures were performed to examine the surfaces’ morphology and structures’ modifications. UV–visible measurements were carried out to investigate the linear/nonlinear optical properties. The optical investigations show significant alterations in the optical parameters of PVA due to ZCS embedding. The UV–visible analysis shows that the optical
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46

Machiels, J. H., S. Subramanian, A. Ruzsa, et al. "An open-label, randomized, phase III trial of zalutumumab, a human monoclonal EGF receptor (EGFr) antibody, versus best supportive care, in patients with noncurable squamous cell carcinoma (SCCHN) of the head and neck who have failed standard platinum-based chemotherapy (ZALUTE)." Journal of Clinical Oncology 28, no. 18_suppl (2010): LBA5506. http://dx.doi.org/10.1200/jco.2010.28.18_suppl.lba5506.

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LBA5506 Background: Zalutumumab is a novel, fully human IgG1 mAb targeting the EGFr that has shown encouraging activity in SCCHN. Methods: Patients with noncurable SCCHN with an ECOG PS of 0-2 and centrally documented radiographic progressive disease (PD) within 6 months after platinum-therapy were randomized between zalutumumab monotherapy and best supportive care (BSC) in a 2:1 ratio. Stratification parameter was ECOG PS. Methotrexate (MTX) was allowed in the BSC arm only. Individual dose-titration of zalutumumab was applied (max. exposure 16 mg/kg). The primary endpoint was overall survival
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47

Mandakhalikar, Kedar Diwakar, Sang Seok Koh, Seong-Yun Jeong, et al. "First-in-class monoclonal antibody (mAb) PBP1510 targeting pancreatic adenocarcinoma upregulated factor (PAUF) for pancreatic cancer (PC) treatment: Preclinical perspectives." Journal of Clinical Oncology 40, no. 16_suppl (2022): e16274-e16274. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e16274.

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e16274 Background: PAUF has been shown to induce PC cell proliferation, angiogenesis and evasion of immune surveillance, thereby promoting tumour progression and metastasis. PBP1510, a novel humanized IgG1 mAb developed by Prestige Biopharma Limited, Singapore, binds to and neutralizes PAUF with high specificity and affinity. With no available targeted therapies against PAUF, the first in its class, PBP1510, has been granted Orphan Drug Designation by EMA, US FDA and Korea MFDS. Methods: To assess inhibition of migration and invasion of PC in vitro, PC cell lines (CFPAC-1 and BxPC-3) with high
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48

Fiskus, Warren C., Lucia Masarova, Christopher Peter Mill, et al. "Preclinical Studies Demonstrating Efficacy of Tasquinimod in Models of Advanced Myeloproliferative Neoplasm (MPN) in Blastic Phase." Blood 142, Supplement 1 (2023): 741. http://dx.doi.org/10.1182/blood-2023-185031.

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The alarmins, S100A8 (A8) and S100A9 (A9), are low molecular weight proteins belonging to the S100 protein family. Also called calprotectins, A8 and A9 can form homodimers or heterodimers and bind Ca++. A8 and A9 are secreted into the extracellular space and plasma, where they interact with TLR4 (Toll like receptor 4), RAGE (Receptor for Advanced Glycation End products) and CD33. Intracellularly, they act as Ca++ biosensors and activate NADPH oxidase, stimulating ROS production, which activates NLRP3 inflammasome. A8 and A9 also amplify the inflammatory response through TLR4, and induce inflam
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49

Koreth, John, Jerome Ritz, Leslie Chinn, et al. "Itolizumab, a Novel Targeted Anti-CD6 Therapy, in Combination with Corticosteroids, Is Well-Tolerated, with Rapid Pharmacodynamic and Clinical Response in Newly Diagnosed Acute Graft-Versus-Host Disease." Blood 138, Supplement 1 (2021): 2891. http://dx.doi.org/10.1182/blood-2021-145721.

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Abstract Introduction: Itolizumab is a first-in-class monoclonal antibody against the co-stimulatory receptor CD6 that blocks its interaction with activated leukocyte cell adhesion molecule (ALCAM), thereby inhibiting T effector (T eff) cell activity and trafficking to target organs. It is being evaluated as a treatment for immuno-inflammatory diseases where T eff cells play a central role including acute graft-versus-host disease (aGVHD). Previous studies reported that ex vivo depletion of donor CD6+ cells in allogeneic hematopoietic cell transplantations lowers the incidence of aGVHD, justif
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50

Deivendran, S. "Genetic variability of populations of Nilaparvata lugens stal (Delphacidae: Hemiptera) as revealed by random amplified polymorphic DNA." Biolife 3, no. 1 (2022): 40–49. https://doi.org/10.5281/zenodo.7260612.

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<strong>ABSTRACT</strong> The Brown Plant Hoppers (BPHs) is one of the most serious insect pests in Asia where rice is widely planted. It is a typical vascular feeder and considered one of the most serious pests of all rice herbivores. It causes reduction in leaf area, photosynthetic rate, nitrogen concentrations of leaf and stem, chlorophyll contents and organic dry weight. It also causes high infestation ratios, reduction in egg numbers and survival ratios of eggs and nymphs on susceptible rice plants. Besides it also transmits several viral diseases that cause crop damage .However, BPH has
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