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Journal articles on the topic 'EMP pathway'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Ronimus, Ron S., and Hugh W. Morgan. "Distribution and phylogenies of enzymes of the Embden-Meyerhof-Parnas pathway from archaea and hyperthermophilic bacteria support a gluconeogenic origin of metabolism." Archaea 1, no. 3 (2003): 199–221. http://dx.doi.org/10.1155/2003/162593.

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Enzymes of the gluconeogenic/glycolytic pathway (the Embden-Meyerhof-Parnas (EMP) pathway), the reductive tricarboxylic acid cycle, the reductive pentose phosphate cycle and the Entner-Doudoroff pathway are widely distributed and are often considered to be central to the origins of metabolism. In particular, several enzymes of the lower portion of the EMP pathway (the so-called trunk pathway), including triosephosphate isomerase (TPI; EC 5.3.1.1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH; EC 1.2.1.12/13), phosphoglycerate kinase (PGK; EC 2.7.2.3) and enolase (EC 4.2.1.11), are extremely

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Li, Jiang-Jing, Bin Deng, Xia-Jing Zhang та ін. "Isoflurane Preconditioning Attenuates Brain Injury Induced by Electromagnetic Pulse via the TLR4/NFκB Signaling Pathway". Oxidative Medicine and Cellular Longevity 2019 (6 січня 2019): 1–13. http://dx.doi.org/10.1155/2019/9653494.

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Electromagnetic pulse (EMP) is a unique type of electromagnetic radiation, and EMP exposure causes a series of biological effects. The nervous system is sensitive to EMP. We studied the neuroprotective effects of isoflurane preconditioning against EMP exposure and used hematoxylin-eosin staining (HE) to observe the effects of electromagnetic pulse and isoflurane preconditioning on neurons. Inflammatory cytokines were detected by enzyme-linked immunosorbent assay (ELISA). Western blotting was used to detect the expression of caspase-3, CD11b, TLR4, and NFκBp65. We found that after EMP exposure,

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3

Chen, Xi, Karoline Schreiber, Jens Appel, et al. "The Entner–Doudoroff pathway is an overlooked glycolytic route in cyanobacteria and plants." Proceedings of the National Academy of Sciences 113, no. 19 (2016): 5441–46. http://dx.doi.org/10.1073/pnas.1521916113.

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Glucose degradation pathways are central for energy and carbon metabolism throughout all domains of life. They provide ATP, NAD(P)H, and biosynthetic precursors for amino acids, nucleotides, and fatty acids. It is general knowledge that cyanobacteria and plants oxidize carbohydrates via glycolysis [the Embden–Meyerhof–Parnas (EMP) pathway] and the oxidative pentose phosphate (OPP) pathway. However, we found that both possess a third, previously overlooked pathway of glucose breakdown: the Entner–Doudoroff (ED) pathway. Its key enzyme, 2-keto-3-deoxygluconate-6-phosphate (KDPG) aldolase, is wid

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4

Årsköld, Emma, Elke Lohmeier-Vogel, Rong Cao, Stefan Roos, Peter Rådström, and Ed W. J. van Niel. "Phosphoketolase Pathway Dominates in Lactobacillus reuteri ATCC 55730 Containing Dual Pathways for Glycolysis." Journal of Bacteriology 190, no. 1 (2007): 206–12. http://dx.doi.org/10.1128/jb.01227-07.

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ABSTRACT Metabolic flux analysis indicated that the heterofermentative Lactobacillus reuteri strain ATCC 55730 uses both the Embden-Meyerhof pathway (EMP) and phosphoketolase pathway (PKP) when glucose or sucrose is converted into the three-carbon intermediate stage of glycolysis. In all cases studied, the main flux is through the PKP, while the EMP is used as a shunt. In the exponential growth phase, 70%, 73%, and 84% of the flux goes through the PKP in cells metabolizing (i) glucose plus fructose, (ii) glucose alone, and (iii) sucrose alone, respectively. Analysis of the genome of L. reuteri

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5

Ahmed, H., B. Tjaden, R. Hensel, and B. Siebers. "Embden–Meyerhof–Parnas and Entner–Doudoroff pathways in Thermoproteus tenax: metabolic parallelism or specific adaptation?" Biochemical Society Transactions 32, no. 2 (2004): 303–4. http://dx.doi.org/10.1042/bst0320303.

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Genome data as well as biochemical studies have indicated that – as a peculiarity within hyperthermophilic Archaea – Thermoproteus tenax uses three different pathways for glucose metabolism, a variant of the reversible EMP (Embden–Meyerhof–Parnas) pathway and two different modifications of the ED (Entner–Doudoroff) pathway, a non-phosphorylative and a semi-phosphorylative version. An overview of the three different pathways is presented and the physiological function of the variants is discussed.

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6

Selkov, E. "The metabolic pathway collection from EMP: the enzymes and metabolic pathways database." Nucleic Acids Research 24, no. 1 (1996): 26–28. http://dx.doi.org/10.1093/nar/24.1.26.

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Sapet, Cédric, Stéphanie Simoncini, Béatrice Loriod, et al. "Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2." Blood 108, no. 6 (2006): 1868–76. http://dx.doi.org/10.1182/blood-2006-04-014175.

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Abstract Thrombin exerts pleiotropic effects on endothelial cells, including the release of microparticles (EMPs) that disseminate and exchange information with vascular cells. Nevertheless, the mechanisms leading to their generation are not elucidated. We performed microarray analysis to identify genes involved in EMP release by the endothelial cell line HMEC-1 in response to thrombin. We identified a group of genes linked to the cytoskeleton reorganization family. Among these, the Rho-kinase ROCK-II presented a high transcription rate. ROCK-I, another Rho-kinase isoform, was not modulated by

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8

Klingner, Arne, Annekathrin Bartsch, Marco Dogs, et al. "Large-Scale13C Flux Profiling Reveals Conservation of the Entner-Doudoroff Pathway as a Glycolytic Strategy among Marine Bacteria That Use Glucose." Applied and Environmental Microbiology 81, no. 7 (2015): 2408–22. http://dx.doi.org/10.1128/aem.03157-14.

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ABSTRACTMarine bacteria form one of the largest living surfaces on Earth, and their metabolic activity is of fundamental importance for global nutrient cycling. Here, we explored the largely unknown intracellular pathways in 25 microbes representing different classes of marine bacteria that use glucose:Alphaproteobacteria,Gammaproteobacteria, andFlavobacteriiaof theBacteriodetesphylum. We used13C isotope experiments to infer metabolic fluxes through their carbon core pathways. Notably, 90% of all strains studied use the Entner-Doudoroff (ED) pathway for glucose catabolism, whereas only 10% rel

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9

Zhang, Y. M., T. Y. Wong, L. Y. Chen, C. S. Lin, and J. K. Liu. "Induction of a Futile Embden-Meyerhof-Parnas Pathway in Deinococcus radiodurans by Mn: Possible Role of the Pentose Phosphate Pathway in Cell Survival." Applied and Environmental Microbiology 66, no. 1 (2000): 105–12. http://dx.doi.org/10.1128/aem.66.1.105-112.2000.

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ABSTRACT Statistical models were used to predict the effects of tryptone, glucose, yeast extract (TGY) and Mn on biomass formation of the highly radioresistant bacterium Deinococcus radiodurans. Results suggested that glucose had marginal effect on biomass buildup, but Mn was a significant factor for biomass formation. Mn also facilitated glucose interactions with other nutrient components. These predictions were verified by in vivo and in vitro experiments. TGY-grown cells metabolized glucose solely by the pentose phosphate pathway (PPP). Although only a fraction of glucose from the medium wa

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Abaurrea, Andrea, Angela M. Araujo, and Maria M. Caffarel. "The Role of the IL-6 Cytokine Family in Epithelial–Mesenchymal Plasticity in Cancer Progression." International Journal of Molecular Sciences 22, no. 15 (2021): 8334. http://dx.doi.org/10.3390/ijms22158334.

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Epithelial–mesenchymal plasticity (EMP) plays critical roles during embryonic development, wound repair, fibrosis, inflammation and cancer. During cancer progression, EMP results in heterogeneous and dynamic populations of cells with mixed epithelial and mesenchymal characteristics, which are required for local invasion and metastatic dissemination. Cancer development is associated with an inflammatory microenvironment characterized by the accumulation of multiple immune cells and pro-inflammatory mediators, such as cytokines and chemokines. Cytokines from the interleukin 6 (IL-6) family play

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Lai, Senyan, Guihua Wang, Xiaonian Cao, Zhaoming Li, Junbo Hu, and Jing Wang. "EMP-1 promotes tumorigenesis of NSCLC through PI3K/AKT pathway." Journal of Huazhong University of Science and Technology [Medical Sciences] 32, no. 6 (2012): 834–38. http://dx.doi.org/10.1007/s11596-012-1043-1.

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12

Chen, Ying-Hua, Zhang-Wei Chen, Hong-Mei Li, Xin-Feng Yan, and Bo Feng. "AGE/RAGE-Induced EMP Release via the NOX-Derived ROS Pathway." Journal of Diabetes Research 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/6823058.

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Objective. Diabetes is associated with accelerated formation of advanced glycation end products (AGEs) that are extensively found in circulating endothelial microparticles (EMPs). This study aimed to investigate whether AGEs have a direct effect on EMP formation and the possible underlying mechanism. Methods. In vitro, cultured human umbilical vein endothelial cells (HUVECs) were incubated with AGEs (200 and 400 μg/ml) for 24 hours with or without pretreatment with anti-RAGE antibody, NOX inhibitor, or ROS scavenger. The number of CD31-positive EMPs was assessed by flow cytometry. Results. The

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13

Borodina, Irina, Charlotte Schöller, Anna Eliasson, and Jens Nielsen. "Metabolic Network Analysis of Streptomyces tenebrarius, a Streptomyces Species with an Active Entner-Doudoroff Pathway." Applied and Environmental Microbiology 71, no. 5 (2005): 2294–302. http://dx.doi.org/10.1128/aem.71.5.2294-2302.2005.

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ABSTRACT Streptomyces tenebrarius is an industrially important microorganism, producing an antibiotic complex that mainly consists of the aminoglycosides apramycin, tobramycin carbamate, and kanamycin B carbamate. When S. tenebrarius is used for industrial tobramycin production, kanamycin B carbamate is an unwanted by-product. The two compounds differ only by one hydroxyl group, which is present in kanamycin carbamate but is reduced during biosynthesis of tobramycin. 13C metabolic flux analysis was used for elucidating connections between the primary carbon metabolism and the composition of th

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14

Siebers, Bettina, Britta Tjaden, Klaus Michalke, et al. "Reconstruction of the Central Carbohydrate Metabolism of Thermoproteus tenax by Use of Genomic and Biochemical Data." Journal of Bacteriology 186, no. 7 (2004): 2179–94. http://dx.doi.org/10.1128/jb.186.7.2179-2194.2004.

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ABSTRACT The hyperthermophilic, facultatively heterotrophic crenarchaeum Thermoproteus tenax was analyzed using a low-coverage shotgun-sequencing approach. A total of 1.81 Mbp (representing 98.5% of the total genome), with an average gap size of 100 bp and 5.3-fold coverage, are reported, giving insights into the genome of T. tenax. Genome analysis and biochemical studies enabled us to reconstruct its central carbohydrate metabolism. T. tenax uses a variant of the reversible Embden-Meyerhof-Parnas (EMP) pathway and two different variants of the Entner-Doudoroff (ED) pathway (a nonphosphorylati

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15

Weber, Jan, Anke Kayser, and Ursula Rinas. "Metabolic flux analysis of Escherichia coli in glucose-limited continuous culture. II. Dynamic response to famine and feast, activation of the methylglyoxal pathway and oscillatory behaviour." Microbiology 151, no. 3 (2005): 707–16. http://dx.doi.org/10.1099/mic.0.27482-0.

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The metabolic dynamics of the Escherichia coli K-12 strain TG1 to feast and famine were studied in glucose-limited steady-state cultures by up- and downshifts of the dilution rate, respectively. An uncoupling of anabolic and catabolic rates was observed upon dilution rate upshifts, apparent through immediately increased glucose uptake rates which were not accompanied by an immediate increase of the growth rate but instead resulted in the temporary excretion of methylglyoxal, d- and l-lactate, pyruvate and, after a delay, acetate. The energetic state of the cell during the transient was followe

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16

Lin, Paul P., Alec J. Jaeger, Tung-Yun Wu, et al. "Construction and evolution of anEscherichia colistrain relying on nonoxidative glycolysis for sugar catabolism." Proceedings of the National Academy of Sciences 115, no. 14 (2018): 3538–46. http://dx.doi.org/10.1073/pnas.1802191115.

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The Embden–Meyerhoff–Parnas (EMP) pathway, commonly known as glycolysis, represents the fundamental biochemical infrastructure for sugar catabolism in almost all organisms, as it provides key components for biosynthesis, energy metabolism, and global regulation. EMP-based metabolism synthesizes three-carbon (C3) metabolites before two-carbon (C2) metabolites and must emit one CO2in the synthesis of the C2 building block, acetyl-CoA, a precursor for many industrially important products. Using rational design, genome editing, and evolution, here we replaced the native glycolytic pathways inEsche

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17

Traby, Ludwig, Marietta Kollars, Khalid Shoumariyeh, et al. "Characterization of the Procoagulant Activity of Two Different Microparticle Species." Blood 116, no. 21 (2010): 1143. http://dx.doi.org/10.1182/blood.v116.21.1143.1143.

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Abstract Abstract 1143 Background: Microparticles (MP) exhibit procoagulant activity by exposure of tissue factor (TF) and consecutive factor (F) × activation via binding to activated FVII (FVIIa). We have shown that TF-negative MP derived from endothelial cells (EMP) after exposure to cisplatin induce thrombin generation in vitro in a TF-independent manner (Lechner et al., J. Thromb. Haemost. 2007). The procoagulant properties of TF-negative MP are not well characterized. We therefore aimed to investigate the mechanisms of coagulation activation by TF-negative EMP (obtained from human pulmona

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18

Yang, Chih-Chi, Meng-Shan Lu, Khanh Chau Dao, Jan-Wei Lin, Yi-Hsiu Chou, and Yung-Pin Tsai. "Comparison of the Influences of Cadmium Toxicity to Phosphate Removal in Activated Sludge Separately Fed by Glucose and Acetic Acid as Carbon Sources." Water 12, no. 4 (2020): 1205. http://dx.doi.org/10.3390/w12041205.

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This study used high and low concentrations of glucose and acetic acid as carbon sources in two aerobic-anoxic-oxic (A2O) processes. Trials were shock loaded with different concentrations of Cd2+. It was observed that the substrate utilization rate decreased when glucose concentration increased and thus the activated sludge of A2O preferred acetic acid as a carbon source over glucose. Under anaerobic conditions, activated sludge readily transformed the substrate into poly-b-hydroxybutyrate (PHB) by the Entner–Douderoff (ED) pathway with ease, but not into poly-b-hydroxyvalerate (PHV) by the Em

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19

Buoncristiani, Umberto, Francesco Galli, Simona Rovidati, et al. "Bicarbonate versus Lactate Buffer in Peritoneal Dialysis Solutions: The Beneficial Effect on Rbc Metabolism." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 16, no. 5 (1996): 511–18. http://dx.doi.org/10.1177/089686089601600514.

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Objective Using the erythrocyte as a model for other kinds of cells not directly exposed to peritoneal dialysis (PD) solutions, we investigated the tolerance of the cell metabolism to lactate and bicarbonate buffers Design We studied, in vivo (in two groups of 5 PD patients each) and in vitro, the Embden-Meyerh of pathway (EMP) because it represents a potential target for the unphysiological effects of lactate or bicarbonate buffers. The EMP is the main glucose-utilizing route in the red blood cell (RBC), producing energy and reducing power. Methods The enzymatic activities of the key steps in

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Altekar, Wijaya, and Vidhya Rangaswamy. "Indication of a modified EMP pathway for fructose breakdown in a halophilic archaebacterium." FEMS Microbiology Letters 69, no. 1-2 (1990): 139–43. http://dx.doi.org/10.1111/j.1574-6968.1990.tb04190.x.

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Mollah, Md Mahi Imam, Shabbir Ahmed, and Yonggyun Kim. "Immune mediation of HMG-like DSP1 via Toll-Spätzle pathway and its specific inhibition by salicylic acid analogs." PLOS Pathogens 17, no. 3 (2021): e1009467. http://dx.doi.org/10.1371/journal.ppat.1009467.

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Xenorhabdus hominickii, an entomopathogenic bacterium, inhibits eicosanoid biosynthesis of target insects to suppress their immune responses by inhibiting phospholipase A2 (PLA2) through binding to a damage-associated molecular pattern (DAMP) molecule called dorsal switch protein 1 (DSP1) from Spodoptera exigua, a lepidopteran insect. However, the signalling pathway between DSP1 and PLA2 remains unknown. The objective of this study was to determine whether DSP1 could activate Toll immune signalling pathway to activate PLA2 activation and whether X. hominickii metabolites could inhibit DSP1 to

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22

Sudarsan, Suresh, Sarah Dethlefsen, Lars M. Blank, Martin Siemann-Herzberg, and Andreas Schmid. "The Functional Structure of Central Carbon Metabolism in Pseudomonas putida KT2440." Applied and Environmental Microbiology 80, no. 17 (2014): 5292–303. http://dx.doi.org/10.1128/aem.01643-14.

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ABSTRACTWhat defines central carbon metabolism? The classic textbook scheme of central metabolism includes the Embden-Meyerhof-Parnas (EMP) pathway of glycolysis, the pentose phosphate pathway, and the citric acid cycle. The prevalence of this definition of central metabolism is, however, equivocal without experimental validation. We address this issue using a general experimental approach that combines the monitoring of transcriptional and metabolic flux changes between steady states on alternative carbon sources. This approach is investigated by using the model bacteriumPseudomonas putidawit

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23

Takahashi, N., and T. Yamada. "Glucose and Lactate Metabolism By Actinomyces Naeslundii." Critical Reviews in Oral Biology & Medicine 10, no. 4 (1999): 487–503. http://dx.doi.org/10.1177/10454411990100040501.

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Actinomyces are among the predominant bacteria in the oral microflora. This review discusses the glucose and lactate metabolism of A ctinomyces naeslundii and its ecological significance in dental plaque. This bacterium has the Embden-Meyerhof-Parnas (EMP) pathway as the main route to degrade glucose. The EMP pathway-derived metabolic intermediates, phosphoenolpyruvate (PEP) and pyruvate, are further converted into different end-products, depending on the environment. Under anaerobic conditions in the absence of bicarbonate, the pyruvate is converted into lactate by a lactate dehydrogenase. In

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Porro, Benedetta, Paola Songia, Veronika A. Myasoedova, et al. "Endothelial Dysfunction in Patients with Severe Mitral Regurgitation." Journal of Clinical Medicine 8, no. 6 (2019): 835. http://dx.doi.org/10.3390/jcm8060835.

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Mitral valve prolapse (MVP) is the most common cause of severe mitral regurgitation. It has been reported that MVP patients—candidates for mitral valve repair (MVRep)—showed an alteration in the antioxidant defense systems as well as in the L-arginine metabolic pathway. In this study, we investigate if oxidative stress and endothelial dysfunction are an MVP consequence or driving factors. Forty-five patients undergoing MVRep were evaluated before and 6 months post surgery and compared to 29 controls. Oxidized (GSSG) and reduced (GSH) forms of glutathione, and L-arginine metabolic pathway were

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Takahashi, N., and J. Washio. "Metabolomic Effects of Xylitol and Fluoride on Plaque Biofilm in Vivo." Journal of Dental Research 90, no. 12 (2011): 1463–68. http://dx.doi.org/10.1177/0022034511423395.

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Dental caries is initiated by demineralization of the tooth surface through acid production from sugar by plaque biofilm. Fluoride and xylitol have been used worldwide as caries-preventive reagents, based on in vitro-proven inhibitory mechanisms on bacterial acid production. We attempted to confirm the inhibitory mechanisms of fluoride and xylitol in vivo by performing metabolome analysis on the central carbon metabolism in supragingival plaque using the combination of capillary electrophoresis and a time-of-flight mass spectrometer. Fluoride (225 and 900 ppm F−) inhibited lactate production f

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Altekar, W. "Ketohexokinase (ATP: ?-fructose 1-phosphotransferase) initiates fructose breakdown via the modified EMP pathway in halophilic archaebacteria." FEMS Microbiology Letters 83, no. 3 (1991): 241–46. http://dx.doi.org/10.1016/0378-1097(91)90483-q.

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Burgé, Grégoire, Claire Saulou-Bérion, Marwen Moussa, Florent Allais, Violaine Athes, and Henry-Eric Spinnler. "Relationships between the use of Embden Meyerhof pathway (EMP) or Phosphoketolase pathway (PKP) and lactate production capabilities of diverse Lactobacillus reuteri strains." Journal of Microbiology 53, no. 10 (2015): 702–10. http://dx.doi.org/10.1007/s12275-015-5056-x.

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Shams, Fariza, Neil J. Oldfield, Karl G. Wooldridge, and David P. J. Turner. "Fructose-1,6-bisphosphate aldolase (FBA)–a conserved glycolytic enzyme with virulence functions in bacteria: ‘ill met by moonlight’." Biochemical Society Transactions 42, no. 6 (2014): 1792–95. http://dx.doi.org/10.1042/bst20140203.

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Moonlighting proteins constitute an intriguing class of multifunctional proteins. Metabolic enzymes and chaperones, which are often highly conserved proteins in bacteria, archaea and eukaryotic organisms, are among the most commonly recognized examples of moonlighting proteins. Fructose-1,6-bisphosphate aldolase (FBA) is an enzyme involved in the Embden–Meyerhof–Parnas (EMP) glycolytic pathway and in gluconeogenesis. Increasingly, it is also recognized that FBA has additional functions beyond its housekeeping role in central metabolism. In the present review, we summarize the current knowledge

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Altekar, Wijaya, and Vidhya Rangaswamy. "Ketohexokinase (ATP: d-fructose 1-phosphotransferase) initiates fructose breakdown via the modified EMP pathway in halophilic archaebacteria." FEMS Microbiology Letters 83, no. 3 (1991): 241–46. http://dx.doi.org/10.1111/j.1574-6968.1991.tb04471.x.

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30

Kopp, Dominik, Peter L. Bergquist, and Anwar Sunna. "Enzymology of Alternative Carbohydrate Catabolic Pathways." Catalysts 10, no. 11 (2020): 1231. http://dx.doi.org/10.3390/catal10111231.

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The Embden–Meyerhof–Parnas (EMP) and Entner–Doudoroff (ED) pathways are considered the most abundant catabolic pathways found in microorganisms, and ED enzymes have been shown to also be widespread in cyanobacteria, algae and plants. In a large number of organisms, especially common strains used in molecular biology, these pathways account for the catabolism of glucose. The existence of pathways for other carbohydrates that are relevant to biomass utilization has been recognized as new strains have been characterized among thermophilic bacteria and Archaea that are able to transform simple pol

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Lacroix, Romaric, Florence Sabatier, Agnès Mialhe, et al. "Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro." Blood 110, no. 7 (2007): 2432–39. http://dx.doi.org/10.1182/blood-2007-02-069997.

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The regulation of plasmin generation on cell surfaces is of critical importance in the control of vascular homeostasis. Cell-derived microparticles participate in the dissemination of biological activities. However, their capacity to promote plasmin generation has not been documented. In this study, we show that endothelial microparticles (EMPs) from tumor necrosis factor α (TNFα)–stimulated endothelial cells served as a surface for the generation of plasmin. The generation of plasmin involved expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) at the surface of EM

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Jia, Shu-Lei, Yan Ma, Zhe Chi, Guang-Lei Liu, Zhong Hu, and Zhen-Ming Chi. "Genome sequencing of a yeast-like fungal strain P6, a novel species of Aureobasidium spp.: insights into its taxonomy, evolution, and biotechnological potentials." Annals of Microbiology 69, no. 13 (2019): 1475–88. http://dx.doi.org/10.1007/s13213-019-01531-1.

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Abstract Purpose This study aimed to look insights into taxonomy, evolution, and biotechnological potentials of a yeast-like fungal strain P6 isolated from a mangrove ecosystem. Methods The genome sequencing for the yeast-like fungal strain P6 was conducted on a Hiseq sequencing platform, and the genomic characteristics and annotations were analyzed. The central metabolism and gluconate biosynthesis pathway were studied through the genome sequence data by using the GO, KOG, and KEGG databases. The secondary metabolite potentials were also evaluated. Results The whole genome size of the P6 stra

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Reddy, Gajendar Komati, Steffen N. Lindner, and Volker F. Wendisch. "Metabolic Engineering an ATP-neutral EMP pathway in C. glutamicum: adaptive point mutation in NADH dehydrogenase restores growth." New Biotechnology 31 (July 2014): S165. http://dx.doi.org/10.1016/j.nbt.2014.05.2031.

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Rivanti, Erlina, Annishfia Lailatur Rohmah, Herwandhani Putri, Prisnu Tirtanirmala та Dyaningtyas Dewi Pamungkas Putri. "Ethanolic Extract of Mangosteen (Garcinia mangostana) Peel Inhibits T47D and Hela Cells Line Proliferation Via Nf-қB Pathway Inhibition". Indonesian Journal of Cancer Chemoprevention 3, № 2 (2012): 391. http://dx.doi.org/10.14499/indonesianjcanchemoprev3iss2pp391-397.

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Effective and selective chemoterapeutic and chemopreventive agent is needed to cure breast and cervical cancers. One of the potential natural material is mangosteen peel (Garcinia mangostana). In this study, we observed cytotoxic effect of ethanolic extract of mangosteen peel (EMP) on HeLa cells line and T47D cells line. The cytotoxic effect was determined using MTT assay.EMP showed cytotoxic effect on T47D cells and HeLa cells with IC50 values of 2.07 μg/ml and 10.58 µg/ml respectively. Molecular docking simulation was done to predict the molecular mechanism of active compund in mangosteen pe

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Albert, Venencia, Arulselvi Subramanian, and Hara Prasad Pati. "Correlation of Circulating Microparticles with Coagulation and Fibrinolysis Is Healthy Individuals." Blood 132, Supplement 1 (2018): 4975. http://dx.doi.org/10.1182/blood-2018-99-120371.

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Abstract Introduction Microparticles (MPs) are small membrane blebs that are released in response to cellular activation or apoptosis from the cell surface by proteolytic cleavage of the cytoskeleton. Previous studies have reported low levels of naturally produced cell-derived microparticle in healthy individuals. This study was conducted to assess whether circulating microparticles induce thrombin generation leading to low grade activation of the coagulation system in healthy individuals. Materials & Methods Flow cytometry analysis of three phenotypes of Platelet derived (PMP), Endothelia

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Wiegmann, Katharina, Michael Hensler, Lars Wöhlbrand, Marcus Ulbrich, Dietmar Schomburg, and Ralf Rabus. "Carbohydrate Catabolism in Phaeobacter inhibens DSM 17395, a Member of the Marine Roseobacter Clade." Applied and Environmental Microbiology 80, no. 15 (2014): 4725–37. http://dx.doi.org/10.1128/aem.00719-14.

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ABSTRACTSince genome analysis did not allow unambiguous reconstruction of transport, catabolism, and substrate-specific regulation for several important carbohydrates inPhaeobacter inhibensDSM 17395, proteomic and metabolomic analyses ofN-acetylglucosamine-, mannitol-, sucrose-, glucose-, and xylose-grown cells were carried out to close this knowledge gap. These carbohydrates can pass through the outer membrane via porins identified in the outer membrane fraction. For transport across the cytoplasmic membrane, carbohydrate-specific ABC transport systems were identified. Their coding genes most

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Chan, Xin Yue, Kah Ooi Chua, Kah Yan How, Wai-Fong Yin, and Kok-Gan Chan. "Global Genome Comparative Analysis Reveals Insights of Resistome and Life-Style Adaptation ofPseudomonas putidaStrain T2-2 in Oral Cavity." Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/930727.

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MostPseudomonas putidastrains are environmental microorganisms exhibiting a wide range of metabolic capability but certain strains have been reported as rare opportunistic pathogens and some emerged as multidrug resistantP. putida. This study aimed to assess the drug resistance profile of, via whole genome analysis,P. putidastrain T2-2 isolated from oral cavity. At the same time, we also compared the nonenvironmental strain with environmentally isolatedP. putida.In silicocomparative genome analysis with available reference strains ofP. putidashows that T2-2 has lesser gene counts on carbohydra

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Ishihara, Rei, Yuki Murakami, Kazuki Homma, et al. "Matrix Metalloproteinase and Tissue Inhibitor of Metalloproteinases Is Associated with Multiple Myeloma Progression, Prognosis and Extramedullary Plasmacytoma." Blood 132, Supplement 1 (2018): 3178. http://dx.doi.org/10.1182/blood-2018-99-113355.

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Abstract Backgrounds and Aims: Matrix metalloproteinase (MMP) is endopeptidase enzyme degrading extracellular matrix, and tissue inhibitor of metalloproteinases (TIMP) is negative regulator of MMP. MMP is well known to be involved in metastatic mechanism of cancer cell and oncogenesis. However expression and role of MMP and TIMP has not been well established in multiple myeloma (MM). Therefore we examined whether expression of MMP and TIMP was involved in progression and prognosis of MM and extramedullary plasmacytoma (EMP) formation. Materials and Methods: Purified bone marrow plasma cells by

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Fontana, Vincenzo, Wenche Jy, Eugene Ahn, et al. "Activation of Clotting Factors in Thrombocytopenia Due to Platelets Destruction: A Possible Compensated Mechanism for Hemostasis." Blood 106, no. 11 (2005): 3999. http://dx.doi.org/10.1182/blood.v106.11.3999.3999.

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Abstract INTRODUCTION. Thrombocytopenia (TP) due to bone marrow failure, as in aplastic anemia (AA), is often associated with frequent and fatal bleeding, whereas fatal bleeding in TP due to platelet destruction, as in ITP, is rare. It has been suggested that giant platelets or increased cell-derived microparticles (MP) act to limit bleeding in ITP. We investigated clotting factors and MP from 3 cell types, platelets (PMP), leukocytes (LMP), and endothelial (EMP), in patients with different causes of their TP. METHODS. Group 1 (platelet destruction) consisted of 2 subgroups, Grp 1a having n=35

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Ha-Tran, Dung Minh, Trinh Thi My Nguyen, Shou-Chen Lo, and Chieh-Chen Huang. "Utilization of Monosaccharides by Hungateiclostridium thermocellum ATCC 27405 through Adaptive Evolution." Microorganisms 9, no. 7 (2021): 1445. http://dx.doi.org/10.3390/microorganisms9071445.

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Hungateiclostridium thermocellum ATCC 27405 is a promising bacterium for consolidated bioprocessing with a robust ability to degrade lignocellulosic biomass through a multienzyme cellulosomal complex. The bacterium uses the released cellodextrins, glucose polymers of different lengths, as its primary carbon source and energy. In contrast, the bacterium exhibits poor growth on monosaccharides such as fructose and glucose. This phenomenon raises many important questions concerning its glycolytic pathways and sugar transport systems. Until now, the detailed mechanisms of H. thermocellum adaptatio

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Nie, Di-min, Qiu-ling Wu, Peng Zheng, et al. "Endothelial microparticles carrying hedgehog-interacting protein induce continuous endothelial damage in the pathogenesis of acute graft-versus-host disease." American Journal of Physiology-Cell Physiology 310, no. 10 (2016): C821—C835. http://dx.doi.org/10.1152/ajpcell.00372.2015.

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Accumulating evidence suggests that endothelial microparticles (EMPs), a marker of endothelial damage, are elevated in acute graft-versus-host disease (aGVHD), and that endothelial damage is implicated in the pathogenesis of aGVHD, but the mechanisms remain elusive. In this study, we detected the plasma EMP levels and endothelial damage in patients and mice with aGVHD in vivo and then examined the effects of EMPs derived from injured endothelial cells (ECs) on endothelial damage and the role of hedgehog-interacting protein (HHIP) carried by EMPs in these effects in vitro. Our results showed th

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Sewastianik, Tomasz, Jianjun Zhao, Meng Jiang та ін. "Overexpression of BCL9, a Wnt/β-Catenin Transcriptional Co-Activator, in Transgenic Mice Promotes Spontaneous Development of B-Cell Malignancies". Blood 128, № 22 (2016): 441. http://dx.doi.org/10.1182/blood.v128.22.441.441.

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Abstract Dysregulation of the Wnt signaling pathway underlies the pathogenesis of a wide range of human cancers, including hematological malignancies such as multiple myeloma (MM). The terminal effector of this signaling pathway is a transcriptional complex formed by β-catenin and BCL9. This complex is of particular interest because the BCL9 locus resides on the frequently recurring 1q21 chromosomal amplification in MM, which has been linked to poor clinical prognosis and outcome. Our previous studies indicate that BCL9-mediated enhancement of β-catenin activity increases cells proliferation,

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Dong, H., and H. Zeng. "Identification of differentially expressed proteins of a new rice mutant with albino green-revertible trait in the seedling stage." Canadian Journal of Plant Science 90, no. 3 (2010): 283–92. http://dx.doi.org/10.4141/cjps09066.

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Chlorophyll-deficient mutants have been employed to study the mechanism of chlorophyll and chloroplast biogenesis in plants. We found a new chlorophyll-deficient mutant rice line (W02S) whose leaves, unlike those of its isogenic line (Peiai64S), became etiolated at the two-leaf stage and turned green at the three-leaf stage. 2-D gel electrophoresis was performed, and proteins that were differentially expressed between W02S and Peiai64S were selected for MALDI-TOF MS analysis. A total of 44 highly differentially expressed proteins were collected from the two-leaf stage of W02S. These 44 protein

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Da'as, Sahar I., Tugce B. Balci, Eileen R. McBride, et al. "Notch Signaling Is Required for Mast Cell Development In the Zebrafish and May Represent a Novel Therapeutic Strategy In Systemic Mastocytosis." Blood 116, no. 21 (2010): 930. http://dx.doi.org/10.1182/blood.v116.21.930.930.

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Abstract Abstract 930 We have been exploiting the advantages provided by the zebrafish system to elucidate the molecular pathways regulating mast cell (MC) development in vertebrates and to model human MC diseases, such as systemic mastocytosis (SM). SM is a pre-leukemic myeloproliferative disease that results from perturbed MC development and proliferation. We have previously described zebrafish MC equivalents; demonstrated the significance of carboxypeptidase A5 (cpa5) as a zebrafish MC-specific marker; and established pu.1 and gata2 as essential transcription factors for early MC developmen

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Zhao, Juan, Qi Zhang, Jing Liu, et al. "Effect of Endomorphins on HUVECs Treated by ox-LDL and Its Related Mechanisms." Journal of Diabetes Research 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/9741483.

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We found in the present study that treatment with ox-LDL decreased the cell viability and the content of nitric oxide (NO) and the activity of nitric oxide synthase (NOS) as well as eNOS mRNA expression, while increasing the mRNA expression and content of endothelin-1 (ET-1) in human umbilical vein endothelial cells (HUVECs). However, endomorphins EM1/EM2 increased the cell viability and the content of NO and the activity of NOS as well as eNOS mRNA expression, while decreasing the mRNA expression and content of ET-1 compared with ox-LDL alone. Meanwhile, the expressions of JNK and p-JNK were

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Huang, Wenbo, and Jing Xie. "Antibacterial Effect of Dihydromyricetin on Specific Spoilage Organisms of Hybrid Grouper." Journal of Food Quality 2021 (June 4, 2021): 1–11. http://dx.doi.org/10.1155/2021/5569298.

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This study aimed to investigate the mechanism of antibacterial activity level inhibition of dihydromyricetin (DMY) against specific spoilage bacteria of grouper. Firstly, the specific spoilage bacteria of grouper in the cold storage process are Pseudomonas antarctica (P. antarctica), which are selected by calculating the spoilage metabolite yield factor. It was determined that the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of DMY against grouper spoilage bacteria were 2.0 mg/mL and 6.4 mg/mL, respectively. DMY was added to the matrix of chitosan and sod

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Wang, Jiexin, Haiqing Chu, Hangying Li, et al. "A Network Pharmacology Approach to Investigate the Mechanism of Erjing Prescription in Type 2 Diabetes." Evidence-Based Complementary and Alternative Medicine 2021 (July 24, 2021): 1–13. http://dx.doi.org/10.1155/2021/9933236.

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Erjing prescription (EJP) was an ancient formula that was recorded in the General Medical Collection of Royal Benevolence of the Song Dynasty. It has been frequently used to treat type 2 diabetes mellitus (T2DM) in the long history of China. The formula consists of Lycium barbarum L. and Polygonatum sibiricum F. Delaroche with a ratio of 1 : 1. This study aimed to identify the potential effects and mechanisms of EJP treatment T2DM. The target proteins and possible pathways of EJP in T2DM treatment were investigated by the approach of network pharmacology and real-time PCR (RT-PCR). 99 diabetes

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Bulut, Daniel, Vanessa Becker, and Andreas Mügge. "Acetylsalicylate reduces endothelial and platelet-derived microparticles in patients with coronary artery disease." Canadian Journal of Physiology and Pharmacology 89, no. 4 (2011): 239–44. http://dx.doi.org/10.1139/y11-013.

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Previous studies suggest that endothelial progenitor cells (EPCs) contribute to vascular repair processes. In contrast, circulating microparticles (MPs) are reported to be part of a process that is damaging to vascular cells. Numerous studies suggest that the “balance” between EPCs and MPs is important for the integrity of vascular cells and preservation of endothelial function. In the present study, we assess the impact of acetylsalicylate (ASA) — which is, beside statins and physical exercise, a third basic column in the preventive therapy of coronary artery disease (CAD) — on EPCs and MPs i

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Abdullah, Ummi, and Paul J. Cullen. "The tRNA Modification Complex Elongator Regulates the Cdc42-Dependent Mitogen-Activated Protein Kinase Pathway That Controls Filamentous Growth in Yeast." Eukaryotic Cell 8, no. 9 (2009): 1362–72. http://dx.doi.org/10.1128/ec.00015-09.

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ABSTRACT Signal transduction pathways control multiple aspects of cellular behavior, including global changes to the cell cycle, cell polarity, and gene expression, which can result in the formation of a new cell type. In the budding yeast Saccharomyces cerevisiae, the mitogen-activated protein kinase (MAPK) pathway that controls filamentous growth induces a dimorphic foraging response under nutrient-limiting conditions. How nutritional cues feed into MAPK activation remains an open question. Here we report a functional connection between the elongator tRNA modification complex (ELP genes) and

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Parslow, G. P., and E. J. Wood. "Database of enzymes and metabolic pathways (EMP)." Biochemical Education 26, no. 2 (1998): 144–45. http://dx.doi.org/10.1016/s0307-4412(98)00124-1.

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