Relevant bibliographies by topics / Empiric Chemotherapy Dose Reduction

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  2. Dissertations / Theses
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Academic literature on the topic 'Empiric Chemotherapy Dose Reduction'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Empiric Chemotherapy Dose Reduction"

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Paba, C., J. Sachdev, L. Kronish, M. Jahanzeb, and S. Waheed. "Empiric dose reduction of pegfilgrastim in breast cancer patients receiving cytotoxic chemotherapy." Journal of Clinical Oncology 26, no. 15_suppl (2008): 20636. http://dx.doi.org/10.1200/jco.2008.26.15_suppl.20636.

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Gupta, N. K., S. Thorpe, P. Vanderhoff, et al. "Pegfilgrastim can be effectively administered the same day as chemotherapy to prevent neutropenia-related complications." Journal of Clinical Oncology 25, no. 18_suppl (2007): 19571. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.19571.

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19571 Background: Pegfilgrastim has been proven to reduce neutropenia-related complications of chemotherapy. However, the administration of pegfilgrastim 24 hours after chemotherapy treatment often poses an inconvenience for the patients and care givers. Methods: A retrospective chart review of the patients who received pegfilgrastim the same day as chemotherapy was done at a rural oncology practice, where some patients travel more than 100 miles each way for treatment. Incidence of febrile neutropenia (FN), defined as ANC = 500 and temperature =101° F; hospitalization for FN; dose-delay; dose
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Guenther, Chad Michael, Nizar Bhulani, Adam Korenke, et al. "Prescribing patterns for FOLFIRINOX in the real world." Journal of Clinical Oncology 36, no. 4_suppl (2018): 463. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.463.

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463 Background: FOLFIRINOX therapy is associated with improved outcome in patients with gastrointestinal cancers. The regimen can be associated with significant toxicity and empiric dose modifications are often used. We analyzed 1) real-world prescribing patterns of FOLFIRINOX and 2) toxicity of therapy. Methods: Patients undergoing FOLFIRINOX chemotherapy at an academic, NCI-Designated Comprehensive Cancer Center were identified and electronic medical records reviewed. Patients who received at least one dose of FOLFIRINOX were included. Chemotherapy dose, growth factor use and toxicity data w
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Thwin, Malar, Aye Min Soe, Nay Min Tun, and Gina M. Villani. "Pattern of chemotherapy dosing in obese patients in a community hospital." Journal of Clinical Oncology 30, no. 15_suppl (2012): e13099-e13099. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e13099.

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e13099 Background: Obesity has increased to epidemic proportions, with 32.2% of US adults aged 20 years or older classified as obese (body mass index ≥ 30 mg/m2). In view of altered pharmacokinetics and possible excessive toxicity in obese patients, chemotherapy dose reductions are often employed in treating obese cancer patients. To our knowledge, there are no reports in the literature identifying patients who should have empiric dose adjustment because of obesity or the best method of dosing chemotherapy to standardize drug exposure in patients with varying degrees of obesity. As practice va
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Ganti, Arun, Weijian Liu, Kristen M. Sanfilippo, and Kenneth R. Carson. "Impact of BMI On Treatment-Related Toxicity in United States Veterans with Diffuse Large B-Cell Lymphoma (DLBCL) Receiving CHOP+/−R." Blood 120, no. 21 (2012): 3172. http://dx.doi.org/10.1182/blood.v120.21.3172.3172.

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Abstract Abstract 3172 Background: Obesity is associated with an increase in all-cause mortality, much of which is due to cancer. Recently, we demonstrated improved survival in overweight and obese Veterans with DLBCL. To better understand this survival disparity, we explored the frequency of dose-reductions and treatment-related mortality (TRM) as they relate to BMI in this population. Methods: We identified a cohort of DLBCL patients diagnosed between 1998 and 2008 in the Veterans Health Administration (VHA) central cancer registry. Additional data on height, weight, treatment drug, dose, da
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Yu, J., N. M. Reddy, A. Rajput, J. Smith, G. Yang, and M. Fakih. "Outcomes and toxicities among octogenarians and nonagenarians with colorectal cancer (crc) treated with chemotherapy or concurrent chemoradiation - a single institution study." Journal of Clinical Oncology 24, no. 18_suppl (2006): 13514. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.13514.

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13514 Background: Chemotherapy is associated with an improved overall survival with acceptable toxicities in patients ≥ 70 years. However, little to no data exists regarding feasibility and tolerability of chemotherapy and/or radiation in CRC patients ≥ 80 years. The purpose of this study was to identify the trends of increased toxicity in this subgroup of patients. Methods: A retrospective study on patients ≥ 80 yrs treated for CRC with either chemotherapy alone or chemoradiation during the period of 1996- 2005 at Roswell Park Cancer Institute was conducted. Survival analysis was performed us
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Hourdequin, Kathryn Cunningham, William Lewis Schpero, Breanne Lee Piazik, Dorothy R. McKenna, and Robin Joyce Larson. "Toxicity of chemotherapy dosing using actual body weight in obese versus normal-weight patients: A systematic review and meta-analysis." Journal of Clinical Oncology 30, no. 15_suppl (2012): 6013. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.6013.

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6013 Background: Because weight-based chemotherapy calculations can be very large in obese patients, oncologists often empirically reduce doses due to fear of excess toxicity. The resulting underdosing may negatively impact survival. We performed a systematic review and meta-analysis to determine whether, among adults receiving chemotherapy dosed by actual body weight (ABW), obese patients experience differing toxicity or survival compared to normal-weight patients. Methods: We searched MEDLINE, Cochrane Library, Web of Science, and ClinicalTrials.gov through October 2011 and reviewed referenc
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Rosero, Gustavo, Gisela Pattarone, Ana Peñaherera, et al. "Metronomic doses and drug schematic combination response tested within chambered coverslips for the treatment of breast cancer cells (JIMT-1)." PLOS ONE 17, no. 9 (2022): e0274911. http://dx.doi.org/10.1371/journal.pone.0274911.

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Low-dose metronomic (LDM) chemotherapy is an alternative to conventional chemotherapy and is the most frequently used approach in low dose chemotherapy regimens. The selection of patients, drug dosages, and dosing intervals in LDM is empirical. In this study, we systematically examined the schedule-dependent interaction of drugs on a breast cancer cell line (BCC) cultured in chambered coverslips. The LDM studies were combined with cell staining in order to better characterize different cell states and cell death modes, including caspase-dependent apoptosis, caspase-independent cell death and a
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Veatch, Joshua R., Ravinder K. Sandhu, Kathleen Shannon-Dorcy, et al. "NCI Common Toxicity Criteria and Mortality After Chemotherapy for Acute Myeloid Leukemia (AML)." Blood 120, no. 21 (2012): 1479. http://dx.doi.org/10.1182/blood.v120.21.1479.1479.

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Abstract Abstract 1479 Abnormal values for creatinine, bilirubin, AST, and ALT following chemotherapy, in particular in phase 1 trials, are interpreted using NCI common toxicity criteria. By convention, grade 3 or 4 toxicity leads to dose reduction while grade 1 or 2 toxicity does not. However, grade 3 – 4 toxicity is typically asymptomatic, calling into question the relevance of these criteria. In an attempt to provide a more empirical basis for decisions we analyzed the relation between (a) grades of NCI toxicity for bilirubin, creatinine, ALT, and AST following chemotherapy for AML and (b)
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Dower, Joshua, Yana Salei, Benjamin Koethe, et al. "Tolerability, dose intensity, and prescribing patterns of capecitabine by race." Journal of Clinical Oncology 42, no. 16_suppl (2024): e23278-e23278. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e23278.

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e23278 Background: Capecitabine (cap) is approved for the treatment of breast and colorectal cancer and is used off-label to treat other solid malignancies. Approved dosing varies by indication and concurrent therapies, and the initial dose of cap may be modified empirically based on different patient characteristics. Race/ethnicity have been used by some providers as factors in prescribing patterns. However, the tolerability of cap among patients of different racial/ethnic backgrounds is unknown. Here, we present an updated analysis outlining the tolerability of cap among patients of differen
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Dissertations / Theses on the topic "Empiric Chemotherapy Dose Reduction"

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Nikolich‐Zugich, Tijana. "Effects of High Vs. Reduced‐Dose Melphalan For Autologous Bone Marrow Transplantation in Multiple Myeloma On Pulmonary Function: A Longitudinal Study." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/623514.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Bone marrow transplants (BMT, also hematopoietic stem cell transplants or HSCT/SCT) are one of the greatest medical achievements of the 20th century. They offer a treatment for a host of malignant and nonmalignant hematopoietic disorders, genetic diseases and solid tumors that could otherwise be fatal. Studies have found that 60% of patients undergoing BMT develop pulmonary complications (PC), and 1/3 of those require intensive care a
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Books on the topic "Empiric Chemotherapy Dose Reduction"

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Welch, Mary R., and Craig Nolan. Chemotherapy and Radiation Therapy. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0143.

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Neurotoxicity is a common problem in oncology practice and neurologists who care for cancer patients encounter a wide range of symptoms attributable to the side effects of radiation and/or chemotherapy. Complications involving the nervous system may be debilitating. Though generally improved by dose reduction or cessation of an offending agent, such symptoms can be irreversible and frequently have a profound impact on quality of life. The appropriate balance between therapeutic efficacy and drug or radiation toxicity requires close attention to the patient’s complaints as well as a thorough un
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Book chapters on the topic "Empiric Chemotherapy Dose Reduction"

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Peters, Christina, Franco Locatelli, and Peter Bader. "Acute Lymphoblastic Leukaemia in Children and Adolescents." In The EBMT Handbook. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-44080-9_73.

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AbstractAcute lymphoblastic leukaemia (ALL) is the most common cancer in children; approximately 60% of ALL cases occur in children and adolescents under the age of 20. Allogeneic haematopoietic cell transplantation (HCT) has become the most commonly used cellular immunotherapy and the standard of care for children with ALL who are either at high risk of relapse or have previously relapsed. HCT is a successful therapeutic option and a significant proportion of patients achieve long-term survival. The most common cause of treatment failure is relapse after allogeneic HCT. The risk of relapse af
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Huang, Shao Hui, Avinash Pilar, Jishi Li, Zhiyuan Xu, and Brian O’Sullivan. "Contemporary Opportunities in Nonsurgical Management of Locoregionally Advanced Head and Neck Squamous Cell Carcinoma." In Critical Issues in Head and Neck Oncology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_9.

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AbstractThe majority of head and neck squamous cell carcinoma (HNSCC) is now classified into two major types: HPV-mediated [HPV(+)] and HPV-negative [HPV(−)]. Within this paradigm, the 8th edition TNM staging system effected modification about what is considered “locally-advanced” HNSCC. Two phase-III trials (RTOG 1016 and De-ESCALATE HPV) disappointingly showed that cetuximab is not as effective in HPV(+) oropharyngeal cancer (OPC) compared to cisplatin with radiotherapy. The recent NRG HN002 de-escalation trial demonstrated the presence of outcome heterogeneity within “low-risk” HPV(+) OPC,
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Cascella, Marco, Maria Rosaria Muzio, Sabrina Bimonte, and Arturo Cuomo. "Nutraceuticals for Prevention of Chemotherapy-Induced Peripheral Neuropathy." In Research Anthology on Recent Advancements in Ethnopharmacology and Nutraceuticals. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-3546-5.ch058.

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A wide range of neurologic complications, including central neurotoxicity conditions and peripheral neurotoxicity, are associated with antineoplastic drug regimens. Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and severe cancer treatment-related adverse effect, as well as the most diffuse type of neurotoxicity, because about one third of all patients who undergo chemotherapy may experience this side effect. CIPN can negatively impact the long-term quality of life of cancer survivors, and can lead to dose reduction of the chemotherapy agent, or possible cessation
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Strauchen, James A. "Effects of Therapy on the Bone Marrow." In Diagnostic Histopathology of the Bone Marrow. Oxford University PressNew York, NY, 1996. http://dx.doi.org/10.1093/oso/9780195097566.003.0003.

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Abstract The bone marrow is one of the organs most sensitive to injury by ionizing radiation. Whole-body irradiation to a dose of 400 cGy results in death of approximately 50% of those exposed as a result of an acute radiation syndrome characterized by marrow hypoplasia. Whole-body irradiation to a dose of 1,000 cGy results in irreversible marrow hypoplasia and is lethal without bone marrow transplantation. Fractionated radiation to localized sites is much better tolerated and doses in the range of 5,000 cGy are routinely employed in the therapy of malignant neoplasms. Localized irradiation re
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Webb, Lauren M., and Eoin P. Flanagan. "Diplopia, Orbital Pain, and Vision Loss in a Middle-Aged Woman." In Mayo Clinic Cases in Neuroimmunology, edited by Andrew McKeon, B. Mark Keegan, and W. Oliver Tobin. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197583425.003.0053.

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A 59-year-old woman with type 2 diabetes had development of fluctuating, binocular, painless diplopia. She experienced headache, orbital pain, facial numbness, and progressive vision loss in the left eye. Her left eye vision worsened. Magnetic resonance imaging of the brain and orbit showed bilateral optic nerve enhancement. She started treatment with empiric intravenous corticosteroids for presumed optic neuritis, which resulted in transient improvement. Subsequently, her vision worsened to no light perception in the left eye, and she had fluctuating vision loss in the right eye. Cerebrospina
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Hilberink, Jacobien, and Gerwin Huls. "Treatment of AML in Older Patients." In Acute Leukemias. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.94979.

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Acute myeloid leukaemia (AML) is a disease mostly diagnosed in older adults. Treatment of older patients with AML remains challenging with higher rates of intrinsic chemotherapeutic resistance and decreased treatment tolerance. Indeed AML in older patients has different clinical and biologic characteristics compared to younger patients. Several treatment options are available for treatment of AML in older patients, namely conventional intensive chemotherapy (‘3 + 7’), low-dose cytarabine, and hypomethylating agents. Combinations with new drugs have been recently approved or are in advanced sta
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Landman-Parker, Judith, and Françoise Montravers. "Hodgkin LymphomaModern Management of Children and Young Adults." In Oxford Textbook of Cancer in Children. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198797210.003.0019.

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Hodgkin lymphoma (HL) is the most common cancer in adolescence and represents 15% of all cases of cancer in children and adolescents. In three decades, HL has become a highly curable lymphoid malignancy with an expected survival rate at ten years of around 90–93%. Further refinements of treatment strategy are needed in order to improve treatment results in relapsed and refractory patients and to reduce long-term morbidity of therapy, mainly secondary malignancies, cardiovascular early morbidity, and impaired fertility. Progress in imaging definition of involvement based on fluorodeoxyglucose-p
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Takami, Hirokazu. "Germ Cell Tumors." In Neuro-Oncology Compendium for the Boards and Clinical Practice, edited by Maciej M. Mrugala, Na Tosha N. Gatson, Sylvia C. Kurz, Kathryn S. Nevel, and Jennifer L. Clarke. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/med/9780197573778.003.0008.

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Abstract Intracranial germ cell tumors (GCTs) are rare central nervous system neoplasms predominantly occurring in pediatric and young adult patients. GCTs predominantly arise in the brain midline, most frequently at the pineal region. The WHO classification defines five histopathological GCT subtypes: germinoma, mature and immature teratoma, yolk sac tumor, choriocarcinoma, and embryonal carcinoma, which are divided into germinomas and non-germinomatous germ cell tumors (NGGCTs). Tumor markers include human chorionic gonadotropin (HCG) and alpha fetoprotein (AFP) in blood serum and cerebrospi
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Abarbanel, David N., and Ivan D. Carabenciov. "Night Sweats and Paraparesis." In Mayo Clinic Cases in Neuroimmunology, edited by Andrew McKeon, B. Mark Keegan, and W. Oliver Tobin. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197583425.003.0064.

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A 78-year-old man sought care for saddle anesthesia, left lower extremity numbness, and bilateral lower extremity weakness. The sensory loss occurred suddenly, starting initially in the left perianal region and over the course of 3 hours extending down to involve the entirety of the left lower extremity. Symptoms were stable until 3 weeks later, when he had a few episodes of urinary incontinence. Diffuse, severe, bilateral, lower extremity weakness developed. The patient reported 6 months of intermittent night sweats. Serum studies were notable for pancytopenia and increased erythrocyte sedime
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Himthani, Dr Manisha. "OROPHARYNGEAL CANCERS." In Futuristic Trends in Medical Sciences Volume 3 Book 4. Iterative International Publisher, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bbms4p1ch4.

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Oropharyngeal cancer is a global health concern, with a significant incidence of 98,400 new cases and 48,100 deaths reported in 2020. This synopsis explores the intricate landscape of oropharyngeal squamous cell carcinoma (OPSCC), emphasizing the impact of risk factors such as smoking, alcohol, and human papillomavirus (HPV) infection. Notably, HPV-positive OPSCC exhibits a more favorable prognosis, leading to a paradigm shift in the AJCC's 8th edition staging. Clinical manifestations vary based on tumor location, with predominant occurrences in the tonsillar region or base of the tongue. HPV-
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Conference papers on the topic "Empiric Chemotherapy Dose Reduction"

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Faustino, C., N. Afonso, B. Sousa, J. Espírito Santo, and H. Rodrigues. "Relative dose intensity reduction in breast cancer adjuvant chemotherapy." In CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-4111.

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Davies, Lauren. "125 Radiation dose reduction for IA chemotherapy patients in IR." In GOSH Conference 2019, Care of the Complex Child. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-gosh.125.

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Bao, T., O. Goloubeva, R. Kirk, et al. "Abstract OT3-1-09: Acupuncture to prevent chemotherapy dose reduction due to chemotherapy-induced peripheral neuropathy in breast cancer patients." In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-ot3-1-09.

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Lumb, Blanche, Mia Brown, Anna Capsomidis, et al. "847 GFR measurement and nephrotoxic chemotherapy dose reduction in paediatric sarcoma patients, a three centre study." In Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference, Liverpool, 28–30 June 2022. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2022. http://dx.doi.org/10.1136/archdischild-2022-rcpch.496.

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Das, Saikat. "Low dose radiation and chemotherapy significantly reduces hypoxic cell population in locally advanced cervix cancer-results of a phase II study." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685259.

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Introduction: Tumor hypoxia is one of the major causes of high incidence of treatment failures to chemoradiation which is the standard of care in locally advanced cervical cancer. The necessity of newer treatment options that can circumvent hypoxia is highly relevant in this group. Use of low dose radiation to enhance the efficacy of cell cycle specific chemotherapy by mechanism of chemopotentiation is one of the elegant approaches reported in the literature. We have already published the feasibility, efficacy and tolerance of low dose radiation and chemotherapy in neoadjuvant setting in cervi
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"Abstract P1-15-08: Higher toxicity of docetaxel for obese women with early breast cancer: lean body mass is a significant predictor of chemotherapy dose intensity reduction." In Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p1-15-08.

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Rosa, Victor Domingos Lisita, Diego Vinícius Gonçalves Santana, Amanda Laíza dos Reis Mota, et al. "RISK FACTORS FOR PERIPHERAL NEUROPATHY INDUCED BY CHEMOTHERAPY IN WOMEN WITH BREAST CANCER AND THEIR CORRELATION WITH QUALITY OF LIFE: A SYSTEMATIC REVIEW." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2031.

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Objective: Chemotherapeutic-induced peripheral neuropathy is one of the most common side effects of breast cancer treatment. Such a condition impacts on quality of life and has repercussions in treatment. The aim of this study was to correlate, by literature review, the risk factors and impact of peripheral neuropathy in women with breast cancer treated with taxanes. Methodology: This is a systematic review to assess the risk factors associated with peripheral neuropathy related to taxane. The literature review consisted of searching the MEDLINE database. The terms used were “neuropathy” or “c
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Devi, Pinki, Ganapathi Bhat, and Harish S. Ahuja. "To Predict Success of Postapheresis Yield and Post–Autologous Transplant Engraftment Based on Preapheresis Peripheral Blood CD34+ Cell Counts: An Indian Scenario–Based Study." In Annual Conference of Indian Society of Medical and Paediatric Oncology (ISMPO). Thieme Medical and Scientific Publishers Pvt. Ltd., 2021. http://dx.doi.org/10.1055/s-0041-1735370.

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Abstract Introduction The use of hematopoietic stem cells for autologous and allogeneic transplantation has increased in the recent past significantly, due to introduction of newer chemotherapeutic drugs, immunological techniques, and better stem cell technology. Among the bone marrow and peripheral blood stem cells, collection of the latter being more convenient to the patient and associated with faster granulocyte and platelet engraftment has been known as preferred method for mobilization. Peripheral blood stem cells can be extracted from the autologous or allogeneic donor. Mobilization of
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