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Dissertations / Theses on the topic 'Empty virus like particles'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Ross, James Finnian. "Reengineering bacterial toxins into virus-like particles." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/6464/.

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The re-design and controlled self-assembly of natural systems into non-natural functional products is a quickly developing area of Synthetic Biology. Specifically, the manipulation of existing, and the introduction of new protein-protein interactions will allow great advances in bionanotechnology. In nature, protein-protein assemblies mediate many cellular processes and exhibit complex and efficient functions. It is thus rational to assume human-guided biomolecular assemblies could embody equally complex functionality designed to address current human needs. Here we present the design and prep

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2

Ruiss, Romana. "Induktion Epstein-Barr Virus-spezifischer Immunantworten durch Exosomen und Virus-like Particles." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-119153.

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3

Mažeikė, Eglė. "Generation of anticancer vaccine based on virus-like particles." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110621_164205-79199.

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In this dissertation the investigation of potential applications of hamster polyomavirus (HaPyV) major capsid protein VP1 based chimeric virus-like particles (VLPs) harboring CTL epitopes for anticancer vaccine development is presented. The objective of this study was to investigate the potential of recombinant HaPyV VP1 based VLPs for anticancer vaccine generation in model systems, including investigation of VP1 applicability for heterologous CTL epitopes insertions, VLPs assembly and ability to induce insert specific immune response in vivo. HaPyV VP1 VLPs carrying CLT epitopes derived from

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4

Zhang, Naru, and 张娜茹. "Study on influenza virus-like particles and ssDNA aptamers." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/200167.

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Since there is an urgent need for development of vaccines and antiviral agents to combat influenza pandemics, this study aimed to develop influenza virus-like particles (VLPs) and aptamers targeting the virus particles as vaccine and antiviral agent candidates. Influenza VLPs containing three structural proteins of hemagglutinin (HA), neuraminidase (NA) and matrix 1 (M1) derived from influenza A/Hong Kong/01/2009 (H1N1) virus (HK/01) were constructed using a Bac-to-Bac baculovirus expression system. The expressed VLPs were purified by sucrose density gradient ultracentrifugation and characte

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5

Hanslip, Simon John. "Production and assembly of human papillomavirus virus-like particles." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614258.

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6

Överby, Anna K. "Uukuniemi virus-like particles : a model system for bunyaviral assembly /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-238-5/.

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7

Venkatesh, Murthy Ambika Mosale. "Virus-like particles as a vaccine against porcine reproductive and respiratory syndrome virus." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/50974.

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Porcine reproductive and respiratory syndrome (PRRS) is the most significant infectious disease currently affecting the swine industry worldwide. Several inactivated and modified live vaccines (MLV) have been developed to curb PRRSV infections. The unsatisfactory efficacy and safety of these vaccines, drives for the development of new generation PRRS universal vaccines. Virus like particles (VLPs) based vaccines are gaining increasing acceptance compared to subunit vaccines, as they present the antigens in more veritable conformation and are even readily recognized by the immune system. Hepati

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8

Keller, Susanne Anita. "Cross-presentation of and cross-priming by virus-like particles /." [S.l.] : [s.n.], 2009. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=18320.

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9

González, Domínguez Irene. "Characterization and purification of HIV-1 based virus-like particles." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670546.

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Les virus-like particles (VLPs) de VIH han sorgit com una prometedora alternativa per al desenvolupament de nous candidats vacunals, però també per al disseny de teràpies avançades en el camp de la nanomedicina. En els últims anys, s’han desenvolupat diferents estratègies d’optimització per la producció de VLPs de VIH en cultius de cèl·lules animals. Malgrat aquests avanços, la manca d’informació sobre el procés de producció de les VLPs a nivell intracel·lular, la necessitat de mètodes analítics adients per la quantificació de les VLPs de VIH i la seua diferenciació d’altres estructures vesicu

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10

Roth, Jeanne-Francoise. "Regulation and assembly of the yeast Ty1 virus like particles." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301254.

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11

Bhella, David. "The three-dimensional structure of TY1 retrotransposon virus-like particles." Thesis, Birkbeck (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314149.

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12

Burden, C. S. "Monolith absorbants as a capture step for virus-like particles." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1398306/.

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Monoliths are an alternative stationary phase format to conventional particle based media for large biomolecules. Conventional resins suffer from limited capacities and flow rates when used for viruses, virus-like particles (VLP) and other nanoplex materials. Monoliths provide an open pore structure to improve pressure drops and mass transport via convective flow. The challenging capture of a VLP from clarified yeast homogenate was used to develop a new monolith separation which found hydrophobic interaction based separation using a hydroxyl derivatised monolith had the best performance. The m

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13

VELEZ, André Filipe Marques. "Produção de virus like particles (VLPs) do vírus chikungunya (CHIKV)." Master's thesis, Instituto de Higiene e Medicina Tropical, 2012. http://hdl.handle.net/10362/19201.

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O vírus Chikungunya (CHIKV) é um alfavírus, transmitido por mosquitos, que causa infecção aguda no Homem caracterizada por febre, mialgia e poliartrite dolorosa e incapacitante que pode durar meses ou anos. Descrito pela primeira vez na Tanzânia em 1952, tornou-se endémico em África, Índia e sudeste Asiático. Desde 2005, os surtos no oceano Índico e no continente Asiático têm atingido proporções e virulência atípicas, com muitos milhares de indivíduos infectados e mortalidade associada. A mobilidade de indivíduos infectados e a alteração dos padrões de distribuição e abundância dos vectores d

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14

Garbutt, Michael. "Assembly and secretion of rubella virus-like particles in mammalian cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq22597.pdf.

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15

Ramalho, Michal Ronit Israel. "Subcellular localisation of virus-like particles : implications for exogenous gene expression." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416870.

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16

SEQUEIRA, Daniela Filipa Policarpo. "Exploring insect cells versatility for production of influenza virus-like particles." Master's thesis, Instituto de Higiene e Medicina Tropical, 2015. http://hdl.handle.net/10362/19341.

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A potential strategy to produce safer and broadly protective influenza vaccines is to co-express, in the same cell host, multiple hemagglutinins (HA) with a matrix protein (M1) which self-assemble in virus-like particles (VLPs). This study demonstrates the suitability of combining stable expression and the baculovirus-expression vector system (BEVs) in insect Hi5 cells for production of such multi-HA Influenza VLPs. Stable pools of Hi5 cells expressing two HAs were generated and later infected with a M1-encoding baculovirus at two cell concentrations (CCIs; 2×106 cells/mL and 3×106 cells/mL).

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17

Tomasicchio, Michele. "Assembly of Omegatetravirus virus-like particles in the yeast Saccharomyces cerevisiae." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1003989.

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The Tetraviridae are a family of ss (+) RNA viruses that specifically infect lepidopteran insects. Their icosahedral capsids are non-enveloped and approximately 40 nm in diameter with T=4 quasi-equivalent symmetry. The omegatetraviruses, which are structurally the best characterised in the family, include Helicoverpa armigera stunt virus (HaSV) and Nudaurelia capensis omega virus (NwV). The omegatetravirus procapsid is composed of 240 identical copies of the capsid precursor proteins, which undergo autoproteolytic cleavage at its carboxyl-terminus generating the mature capsid protein (b) and γ

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18

Yan, Ruiyang. "Targeted delivery of anti-cancer drugs by MS2 virus-like particles." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/8989/.

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Problems associated with poor pharmacokinetics and biodistribution, as well as toxic off-target effects, limit the curative potential of most anti-cancer drugs. This has prompted the development of nanoparticulate drug delivery systems to impart both more favourable pharmacological properties and precise tumour targeting. The vast number of formulations, ranging from fully synthetic delivery systems to ones derived from natural sources, currently undergoing clinical trials or preclinical testing underlines the significance of this field. This project is a proof-of-concept investigation into th

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19

Marraiki, Najat A. Y. "Recombinant virus like particles comprising hepatitis C virus (HCV) structural proteins and HCV replicon RNA." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422629.

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20

Leung, Lok Chun Rogen. "Novel fluorescence and fluorine labelling methods for viruses and virus-like particles." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:26f1f546-367a-4a6d-8d01-8b05ef24ac74.

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Molecular imaging involves the development of probes which can specifically label a certain object in the body at cellular or subcellular level. This thesis consists of three parts, each involving the development of novel labelling methods for viruses or virus-like particles with specific applications. Virus-like particles (VLP) derived from the E. coli bacteriophage Qβ are widely employed as a nano-carrier for drugs and vaccines, but a powerful method for tracing its circulation without affecting its structure is yet to be developed. In the first part of the thesis, the electrophilic flu

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21

Valley-Omar, Ziyaad. "RNA transmission and expression from inert HIV candidate vaccine virus-like-particles." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/4345.

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Includes abstract.<br>Includes bibliographical references (leaves 136-158).<br>HIV-1 Gag virus-like-particles (VLPs) produced in various expression systems are potent stimulators of both cellular and humoral immune responses in animal models. The encapsidation of large concentrations of random cellular RNA species is known to accompany the assembly of HIV virus particles. This RNA plays a crucial role by serving as a molecular scaffold for the assembly of Gag structural proteins into particles. Non-pseudotyped VLPs that do not present any HIV envelope glycoproteins are regarded as inert partic

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22

Al, Shaikhahmed K. "Developing virus-like particles (VLPs) and heterologous VLPs vaccines for epizootic hemorrhagic disease virus (EHDV) serotypes." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2015. http://researchonline.lshtm.ac.uk/2172948/.

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Epizootic Hemorrhagic Disease Virus (EHDV) is an insect-transmitted pathogen of ruminants, causing periodic and significant losses in wild and captive deer populations and less frequently, a bluetongue-like disease in cattle. The serogroup of EHDV within the Orbivirus genus of the Reoviridae family consists of seven serotypes, in which emerging serotypes pose an increasing risk either regionally or globally, due to the insect vectors. To date, no vaccine against EHDV is commercially available, apart from the live-attenuated vaccine for EHDV-2 (IBAV). In this study, Virus-Like Particles (VLPs)

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23

Halsey, Richard James. "Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles." Master's thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/4269.

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Includes bibliographical references (leaves 114-128).<br>In this study I explored the possibility of making HIV-1 subtype C Pr55gag-based chimaeric virus-like particles (VLPs) as a boost to the HIV-IC multigene DNA vaccine pTHr.grttnC, which encodes a modified Gag-RT-Tat-Nef fusion protein (GRTTN). Furthermore, an attempt was made to produce VLP analogues to the HIV-IA polyepitope DNA vaccine pTHr.HIVA. A range of in-frame fusions with the C-termini of myristylation-competent p6-truncated Gag and native Pr55gag were made to test how the length of polypeptide and its sequence might affect VLP f

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24

Afraz, Zahra [Verfasser]. "Investigation of Virus-Like-Particles and Antigen-Loaded Poly-Lactic-Acid Particles for Transcutaneous Vaccine Delivery / Zahra Afraz." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1074871049/34.

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25

Hirschberg, Sandra. "The regulation of immune responses using virus-like particles carrying allergen-derived peptides." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368166.

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26

Mohsen, Mona. "Virus-Like Particles (VLPs) platform for the development of an effective melanoma vaccine." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:57fefb18-ff84-4add-b4d8-e69e9c4f46a4.

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Melanoma is the least common type of skin-cancer but the deadliest one. Cancer immunotherapy is considered a powerful tool in cancer treatment. Nevertheless, therapeutic cancer vaccines have led so far to modest immune responses with little clinical impact. The first part of this work is focused on developing a personalized melanoma vaccine platform based on VLPs and copper-free click chemistry, enabling bedside production of personalized cancer vaccines. There is currently a debate in the field whether cancer-specific, non-mutated germ-line epitopes or mutated neo-epitopes are more powerful a

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27

Bayliss, Marc Ashley. "Virus-like particles as a novel platform for delivery of protective Burkholderia antigens." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/25577.

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A thesis by Marc Ashley Bayliss entitled ‘Virus-like particles as a novel platform for delivery of protective Burkholderia antigens’ and submitted to the University of Exeter for the degree of Doctor of Philosophy. There is currently no licensed vaccine available for the global tropical pathogen Burkholderia pseudomallei which is the causative agent of melioidosis and a potential bio-threat agent. The capsule polysaccharide (CPS) expressed by B. pseudomallei has been shown to offer some protection against bacterial challenge. Polysaccharide immunogenicity can be enhanced by conjugation to a ca

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28

Pantua, Homer Dadios. "Requirements for Assembly and Release of Newcastle Disease Virus-Like Particles: A Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/242.

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The final step of paramyxovirus infection requires the assembly of viral structural components at the plasma membrane of infected cells followed by budding of virions. While the matrix (M) protein of some paramyxoviruses has been suggested to play a central role in the assembly and release of virus particles, the specific viral and host protein requirements are still unclear. Using Newcastle disease virus (NDV) as a prototype paramyxovirus, we explored the role of each of the NDV structural proteins in virion assembly and release. For these studies, we established a virus-like particle (VLP) s

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29

Crisci, Elisa. "Immunogenic properties of calicivirus-like particles as vaccine vectors." Doctoral thesis, Universitat Autònoma de Barcelona, 2011. http://hdl.handle.net/10803/83962.

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Las nuevas vacunas de subunidades están abriéndose paso dentro de la vacunología veterinaria y entre ellas, las pseudopartículas virales o VLPs (por su nombre en inglés “virus-like particles”) son una de las estrategias más atractivas que están abriendo nuevas fronteras en la vacunación de animales. Las VLPs son estructuras proteicas rígidas con un tamaño dentro del rango de los nanómetros, que presentan una geometría muy bien definida y una espectacular uniformidad que mimetiza la estructura de los virus nativos de los que proceden. Las VLPs tienen importantes ventajas en relación a la

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30

Gutiérrez, Granados Sonia. "HIV virus-like particle production in cap cells." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/405329.

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Les virus-like particles (VLPs) derivades de l’HIV presenten un gran potencial com a vacunes de nova generació. La proteïna Gag s’ensambla de forma espontània a la membrana cel·lular, donant lloc a VLPs amb embolcall. Per a generar VLPs en suficient quantitat i amb la qualitat requerida per a estudis clínics, es necessiten processos de producció robustos. A més, la disponibilitat de mètodes analítics senzills i confiables és crítica per al desenvolupament, optimització i monitorització d’aquests processos. Les cèl·lules de mamífer són la plataforma preferida per a produir VLPs, ja que pr

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31

Wilson, Louise Elizabeth. "Presentation of respiratory syncytial virus F protein epitopes on the surface of hepatitis B virus core-like particles." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240304.

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32

Palmer, Kevin. "Icosahedral structure of TY1 retrotransposon virus-like particles by image processing of electron micrographs." Thesis, Birkbeck (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362464.

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33

Jin, J. "Lipid foulant interactions during the chromatographic purification of virus-like particles from Saccharomyces cerevisiae." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1302065/.

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The objective of this study was to understand the mechanism of lipid fouling in chromatography through the investigation of a hydrophobic interaction chromatography (HIC) operation. This was motivated by the need to understand this phenomenon during the manufacture of biological products such as vaccines. The systematic approach and novel analytical techniques employed create a unique platform to study fouling of other chromatographic adsorbents and process feed materials. HIC is employed as a primary capture step in the purification of yeast derived hepatitis R surface antigen (HBsAg), where

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34

Naupu, Paulina Ndinelago. "The Immunogenicity of Plant-produced Human Papillomavirus (HPV) Virus-like particles (VLPs) in Mice." Master's thesis, Faculty of Science, 2019. https://hdl.handle.net/11427/31794.

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Cervical cancer is caused by infection with high-risk Human papillomaviruses (HPVs). It is ranked fourth among the top cancers in women worldwide, with ~87% of the global cervical cancer cases reported in developing countries. The HPV L1 capsid protein can self-assemble into virus-like particles (VLPs) that are structurally like native virions, which is the foundation on which commercially available vaccines have been developed. There are 3 commercially available HPV vaccines that are effective at preventing HPV infections, but are expensive, therefore limiting their use in the poorer developi

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35

Wu, Cheng Ying. "Characterization of innate immune response to «Nicotiana benthamiana»-derived Influenza H5 virus-like particles." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119400.

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Current influenza vaccine manufacturing processes using chicken-embryonated egg technology is a time-consuming and laborious process, and is currently the major drawback in counteracting pandemic influenza strain. One solution to that problem is the use of plants to generate vaccine antigen. Virus-like particles (VLP), produced from the tobacco plant Nicotiana benthamiana, represent a cost-effective, alternative platform for influenza vaccine production. Previous studies have shown that the immunization with VLP expressing the hemagglutinin (HA) protein from influenza virus H5N1 (H5-VLP) produ

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Lu, Yi. "Development of Virus-like particles (VLPs) Based Vaccines Against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Epidemic Diarrhea Virus (PEDV)." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/104945.

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Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine epidemic diarrhea virus (PEDV) are two of the most prevalent swine pathogens that have impacted the global swine industry for decades. Both are RNA viruses with increasing heterogeneity over the years, making a vaccine solution ever so challenging. Modified live-attenuated vaccines (MLVs) have been the most common approach, but the long-term safety regarding their potential for pathogenic reversion still needs to be addressed. Subunit based vaccines have been the focus of numerous development studies around the world with

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37

Loisy, Fabienne. "Devenir des virus entériques humains en milieu marin : apport des VLPs (Virus Like Particles) pour la purification des coquillages." Paris 11, 2004. http://www.theses.fr/2004PA114826.

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Cette thèse s'est développée selon deux axes de recherche: l'amélioration de la détection des norovirus (humains et animaux) et des rotavirus, et l'évaluation du potentiel des VLPs comme substitut viral pour l'étude de leur devenir en milieu marin. Le point majeur concernant l'optimisation de la détection est la mise au point de la détection des norovirus par RT-PCR en temps réel. La seconde partie du travail a permis de mettre en évidence le potentiel des VLPs de RV et de NV à se substituer aux virus natifs, prouvé par une étude de stabilité des particules en eau de mer naturelle. Grâce à leu

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38

Tegerstedt, Karin. "Studies on polyomavirus virus-like particles - as vaccines and vectors for immune and gene therapy /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-691-3/.

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Chaves, Lorena Carvalho de Souza. "Uso de baculovírus como ferrramenta para produção de antígenos vacinais e “virus like particles” (VLPs)." reponame:Repositório Institucional da UnB, 2016. http://repositorio.unb.br/handle/10482/21421.

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Tese (doutorado)—Universidade de Brasília, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Biologia Molecular, 2016.<br>Texto liberado parcialmente pelo autor. Conteúdo restrito: Capítulo 2 e Anexos.<br>Submitted by Fernanda Percia França (fernandafranca@bce.unb.br) on 2016-07-26T16:10:44Z No. of bitstreams: 1 2016_LorenaCarvalhodeSouzaChaves_Parcial.pdf: 2413443 bytes, checksum: c9dc564135b9d2985ba35dcfc919d239 (MD5)<br>Approved for entry into archive by Raquel Viana(raquelviana@bce.unb.br) on 2016-09-08T19:10:33Z (GMT) No. of bitstreams: 1 2016_LorenaCarvalhodeSouzaChaves_Par

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Crabtree, Brenda Gail. "Studies on the immunogenicity in swine of influenza A virus hemagglutinin expressed by Venezuelan equine encephalitis virus-like replicon particles." [Ames, Iowa : Iowa State University], 2007.

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41

Toffoletto, Marta. "Ingegnerizzazione della proteina di matrice M1 del virus dell'influenza per la produzione di virus-like particles (VLPs) a scopo vaccinale." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3426631.

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Influenza viruses represent a significant public health problem, since they are the etiological agents of acute respiratory illness that can occur in annual epidemics or in occasionally pandemic events. Influenza viruses constantly evolve by the accumulation of point mutations at the level of their antigenic determinants hemagglutinin and neuraminidase (antigenic drift), or as a result of a genetic reassortment (antigenic shift), usually happening when avian and human viruses co-infect an intermediate host. The high rate of mutations, the possibility of reassortment of gene segments and the wi

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42

Wu, Cheng. "Hybrid colloidal molecules from self-assembly of viral rod-like particles." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0133.

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Dans cette thèse, l’auto-assemblage en molécules colloïdales de virus en forme de filament, les bactériophages M13, est étudié. Comme première approche, l’affinité de la streptavidine pour la biotine ou un Strep-tag est utilisée et quantitativement comparée. Pour ce faire, des virus modifiés génétiquement, M13-AS, présentant des Strep-tag et des virus M13C7C chimiquement bioconjugués par de la biotine ont réagi via leur extrémité proximale avec des nanoparticules fonctionnalisées par de la streptavidine. Il en résulte la formation de molécules colloïdales en étoile, dont la valence ou nombre d

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Dias, e. Souza Menira B. L. "Immune responses to human norovirus and human norovirus virus-like particles in gnotobiotic pigs and calves." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1179879281.

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44

Ladd, Effio Christopher [Verfasser], and J. [Akademischer Betreuer] Hubbuch. "Novel development tools for processing of recombinant virus-like particles / Christopher Ladd Effio. Betreuer: J. Hubbuch." Karlsruhe : KIT-Bibliothek, 2016. http://d-nb.info/1084112450/34.

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Ma, Yuanmei. "Vesicular Stomatitis Virus as a Vector to Deliver Virus-Like Particles of Human Norovirus| A New Live Vectored Vaccine for Human Norovirus." Thesis, The Ohio State University, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3710293.

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<p> Human norovirus (NoV) is the leading cause of acute non-bacterial gastroenteritis worldwide. Despite the significant health, emotional, and economic burden caused by human NoV, there are no vaccines or therapeutic interventions for this virus. This is due in major part to the lack of a cell culture system and an animal model for human NoV infection.</p><p> Thus, a vector-based vaccine may be ideal for controlling this disease. The major capsid gene (VP1) of a human NoV was inserted into the VSV genome at the glycoprotein (G) and large (L) polymerase gene junction. Recombinant VSV express

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Ma, Yuanmei. "Vesicular Stomatitis Virus as a Vector to Deliver Virus-Like Particles of Human Norovirus: A New Live Vectored Vaccine for Human Norovirus." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1357303520.

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Nguyen, Thi Thai An [Verfasser], and Michael [Akademischer Betreuer] Nassal. "Recombinant fluorescent myristoylated PreS-containing Hepatitis B virus capsid- like particles = Rekombinante fluoreszierende und myristoylierte PreS-tragende Hepatitis B Virus Kapsidähnliche Partikel." Freiburg : Universität, 2012. http://d-nb.info/1123472548/34.

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Ayranci, Diyar. "Design, expression and purification of virus-like particles derived from metagenomic studies : Virus-like Particles (VLP) of novel Partitiviridae species, Hubei.PLV 11, and novel Soutern pygmy squid flavilike virus were designed, expressed using the bac-to-bac expression system and then pruified using various methods." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-452049.

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Viruses are entities which are made of a few genes and are reliant on obligate parasitism to propagate. Due to the obligate connection to their hosts, virus evolution is constrained to the type of host. Viruses however do transmit to evolutionary distinct hosts; in these cases, the phylogenetic relationship of the hosts usually are close. In some instances, RNA-viruses have made host jumps between evolutionary distant hosts, such as the host jump from invertebrates to vertebrates, and fungi to arthropod. Partitiviruses are double stranded RNA viruses which mainly infect fungi and plants. The d

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Zahid, Maria [Verfasser]. "Production in Pichia pastoris and characterization of genetically engineered hepatits B surface antigen virus-like particles / Maria Zahid." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2013. http://d-nb.info/1033016381/34.

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YANSHINA, Yulia Aleksandrovna. "Avaliação do processo de imunização de murganhos vacinados com virus-like particles (VLPs) contendo candidatos antigénicos de Trypanosoma cruzi." Master's thesis, Instituto de Higiene e Medicina Tropical, 2017. http://hdl.handle.net/10362/20476.

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A doença de Chagas, também denomianada de Tripanossomíase Americana, é uma infeção causada pelo protozoário flagelado Trypanosoma cruzi. Foi estimado que 7 milhões de pessoas do mundo estão infetadas com T. cruzi e mais de 25 milhões estão em risco de infeção. Ao longo dos anos têm sido testados vários antigénios com o intuito de produzir vacinas contra a doença de Chagas e até o presente nenhuma destas conseguiu chegar a ensaios clínicos em humanos, embora tenham sido aplicadas várias estratégias imunoterapêuticas para combater a infeção, tais como vacinas de DNA e antigénios recombinantes. A

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