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1

Prakash, Nathaniel Kumar Sarella, and Rama Krishna Pravallika Godavari Lakshmi. "The Expanding Scope of Emulgels: Formulation, Evaluation and Medical Uses." International Journal of Current Science Research and Review 06, no. 05 (2023): 3030–41. https://doi.org/10.5281/zenodo.7982582.

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<strong>ABSTRACT: </strong>Emulgels are semi-solid emulsions that combine the benefits of both emulsions and gels. They provide enhanced stability, sustained release and improved cosmetic properties. Emulgels can be fabricated using a variety of emulsification techniques and gelling agents like carbopol, hydroxypropyl cellulose. Characterization of emulgels includes evaluation of particle size, viscosity, pH, spreadability and drug release. Emulgels have promising applications in topical delivery of drugs and cosmetics, parenteral delivery of drugs and as emulsion-based oral drug delivery syst
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Manaswitha, A., P. V. L. D. Sai Swetha, N. K. D. Devi, K. Naveen Babu, and K. Ravi Shankar. "Oleic Acid Based Emulgel for Topical Delivery of Ofloxacin." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 183–90. http://dx.doi.org/10.22270/jddt.v9i4-a.3451.

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The objective of the present study is to formulate and evaluate ofloxacin emulgel. Emulgel formulations of ofloxacin were prepared using different concentrations of gelling agent’s Carbopol-940 and Xanthum gum. Tween-80 and span-80 were used as emulsifiers and propylene glycol as a humectant in the preparation of emulgel. The effect of the concentration of gelling agent on the drug release from the prepared emulgel was investigated. The compatibility study was conducted using Fourier-transform infrared (FTIR). The formulated emulgel was characterized by their physical appearance, pH determinat
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I. Khalil, Yehia, Abeer H. Khasraghi, and Entidhar J. Mohammed. "Preparation and Evaluation of Physical and, Rheological Properties of Clotrimazole Emulgel." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 20, no. 2 (2017): 19–27. http://dx.doi.org/10.31351/vol20iss2pp19-27.

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Recently, emulgel has emerged as one of the most interesting topical preparations in the field of pharmaceutics. In this research clotrimazole was formulated as topically applied emulgel ; different formulas were prepared. The prepared emulgels were evaluated for their physical appearance , rheological behaviour , and in vitro drug release . The influence of the type of gelling agent (carbopol 934 and methyl cellulose), the concentration of both the emulsifying agent (2% and 4% w/w of mixture of span 20 and tween 20) and the oil phase (5% and 7.5% w/w of liquid paraffin) and the type of oil ph
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4

Nishant, Chawla, Vishwakarma D.K, and Nayak Jyoti. "Review Article of Emulgel." International Journal of Medical and Pharmaceutical Research 4, Special Issue-3 (2023): 66–75. https://doi.org/10.5281/zenodo.8124562.

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An emulgel is a semi-strong detailing that joins the properties of an emulsion and a gel. It comprises of a hydrophilic gel organization, which is shaped by cross-connecting polymers, and an oil stage that is balanced out by surfactants. Emulgels have acquired ubiquity in the drug and corrective businesses because of their capacity to convey both hydrophilic and hydrophobic actives to the skin. They offer benefits like upgraded skin infiltration, delayed discharge, and further developed dependability. This theoretical plans to give a complete outline of the emulgel definition, the job of its p
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Indresh, Kumar* Sanjay Kushwaha. "Emulgels: Revolutionizing Topical and Transdermal Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 2840–50. https://doi.org/10.5281/zenodo.15270702.

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Emulgels are a groundbreaking hybrid drug delivery system that combines the solubility-enhancing benefits of emulsions with the controlled-release properties of gels. This biphasic formulation excels in topical and transdermal applications, enhancing drug stability, bioavailability, and skin permeation for both hydrophilic and lipophilic active pharmaceutical ingredients. Emulgels provide sustained release, improved patient compliance, and reduced systemic side effects compared to traditional creams, ointments, and gels. This review offers a comprehensive exploration of emulgel composition, dr
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Singh, Adity, and Nidhi Srivastav. "Phytomolecules to Improve Skin Health: A polyherbal Emulgel Formulation." Journal of Advanced Zoology 44, S-5 (2023): 1008–18. http://dx.doi.org/10.17762/jaz.v44is-5.1085.

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Due to its ability to combine the advantages of several herbal extracts with emulsion-based delivery technologies, polyherbal emulgel compositions have attracted a lot of attention in the cosmetics sector. The creation and assessment of polyherbal emulgels for skincare applications are explored in this work. The effective blending of diverse herbal extracts to combat certain skin issues including acne, inflammation, and ageing is one of the key breakthroughs. The regulated and sustained release of active ingredients by the emulgels suggested possible long-lasting benefits and enhanced skin pen
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7

Nilesh, Pawar* Yashpal More Om Birari Harshal Gosavi. "Formulation and Evaluation of Antiacne Topical Emulgel: A Comprehensive Review." International Journal of Scientific Research and Technology 2, no. 5 (2025): 374–83. https://doi.org/10.5281/zenodo.15423892.

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The latest developments in emulgel formulations for cosmeceutical applications are examined in this thorough analysis.&nbsp; Emulgels provide improved stability, bioavailability, and targeted administration of active chemicals in skincare products by fusing the advantages of emulgel systems and nanotechnology.&nbsp; The review focuses on the essential elements of emulgels, such as the selection of oils, gelling agents, and surfactants, and how these affect the formulation's characteristics.&nbsp; There is discussion of developments in characterisation techniques, preparation procedures, and th
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8

Rakesh R.Gore, Aditi A Kasture, Manjunath G. Mukkane, Bhimaskankar K.Bhui, Sandip V.Jadhav, and Rani M.Mhetre. "A new method for improved topical drug delivery, Emulgel." International Journal of Science and Research Archive 10, no. 2 (2023): 1133–43. http://dx.doi.org/10.30574/ijsra.2023.10.2.1072.

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Emulgel is used to treat injuries and diseases such as arthritis, headaches, muscle aches, backaches, and those brought on by colds. Patient compliance with topical formulations is crucial in the treatment of chronic dermatosis such psoriasis, acne, and fungal infections. Emulgel, a more recent NDDS technology used topically, combines the characteristics of an emulsion with a gel to provide a dual control release. Emulgels have emerged as one of the most exciting topical delivery methods because of their dual release control mechanism, which combines a gel with an emulsion. Gels have many bene
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9

Navneet, Kumar Verma* Pragya Mishra Shweta Yadav Ravindra Singh Sushil Kumar Tiwari. "A Brief Review On Emulgel: Recent Advances." International Journal in Pharmaceutical Sciences 1, no. 11 (2023): 559–70. https://doi.org/10.5281/zenodo.10213426.

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Numerous advantages of gels Delivery of hydrophobic medications is severely limited. In order to overcome this limitation and take advantage of the unique properties of gels, even a hydrophobic medicinal moiety is being treated with an emulsion-based approach. The dosage form produced by mixing gels and emulsions is called an emulgel. Dermatological pharmacology is unique in that it uses the skin as a target organ that is directly accessible for diagnosis and treatment. The interaction of hydrophilic cornified cells with hydrophobic intercellular material blocks both hydrophilic and hydrophobi
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10

Saleha, Firoz Tamboli* Suhana Afjal Tamboli Shital B. Gondkar. "Saleha Firoz Tamboli*, Suhana Afjal Tamboli, Shital B. Gondkar." International Journal in Pharmaceutical Sciences 2, no. 6 (2024): 595–605. https://doi.org/10.5281/zenodo.11550736.

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Topical drug delivery is one of the most effective ways to provide a wide range of therapeutic candidates, and emulgels are developing as a novel formulation that combines the properties of emulsions and gels. Emulgel has numerous promising features for dermatological usage, including being greaseless, readily removable, easily spreadable, emollient, non-staining, having a longer shelf life, being transparent, having an elegant appearance, and having a low risk of major adverse effects. Several investigations have shown that emulgel has enhanced penetrability and is capable of delivering both
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11

Niraj, Kumar, and Saxena Charu. "A Novel Approach for Topical Drug Delivery System–Emulgel." Trends in Pharmaceuticals and Nanotechnology 1, no. 2 (2019): 27–32. https://doi.org/10.5281/zenodo.3359349.

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<em>There are various advantages in topical route over the other route of administration. It is a topical drug delivery system. The most important route is gels which provide faster drug release compared with other topical drug delivery, but gel has a limitation that it is used only for hydrophobic drugs; this can be overcome by Emulgels. Emulgels are a type of emulsion may be oil in water or water in oil type; they are incorporated into gelling agent. Emulgel is more effective than regular gel in various aspects and permeation of drug in emulgel is more compared to normal gel. Permeation enha
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Govind, Patidar* Praveen Khirwadkar Tanu Bhargav. "Incorporation Of Neomycin-Nicotinamide Microemulsion in Emulgel for Enhanced Antibacterial Skin Therapy." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1145–68. https://doi.org/10.5281/zenodo.14874104.

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This study focused on the development and evaluation of Emulgel formulations containing Neomycin and Nicotinamide for potential use in antibacterial skin therapy. Three formulations, F1, F2, and F3, were prepared using Carbopol 940, Carbopol 934, and Hydroxypropyl Methylcellulose (HPMC) as the base polymers, respectively. The formulations were characterized for &lambda;max using UV spectroscopy, which identified the optimal wavelengths for Neomycin (270 nm) and Nicotinamide (262 nm). Calibration curves were established to facilitate accurate quantitative analysis of these active pharmaceutical
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13

Thombre, Nilima A., Pooja S. Niphade, Eknath D. Ahire, and Sanjay J. Kshirsagar. "Formulation Development and Evaluation of Microemulsion Based Lornoxicam Gel." Biosciences Biotechnology Research Asia 19, no. 1 (2022): 69–80. http://dx.doi.org/10.13005/bbra/2968.

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The objective of the existing research was formulation development and preparation of microemulsion loaded emulgel in augmenting the topical delivery of Lornoxicam. Emulsion and gel combined are recognized as Emulgels. Gelling agents Carbopol 940, 974, 980 were used to formulating Lornoxicam emulgel. The drug release from emulgel was determined depending on the different gelling agents. Clove oil for internal phase and Polyethylene glycol 200 was applied as co-surfactant and Tween 20 as permeation enhancer. Prepared emulgels were evaluated for in-vitro and in- vivo anti-inflammatory activity u
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14

Zulhakim, Iqmal, Kathina Deswiaqsa, and Jane Arantika. "Formulation and Physical Evaluation of Kratom (Mitragyna speciosa Korth.) Leaf Extract Emulgel as Analgesic in Mice (Mus musculus)." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 12, no. 1 (2025): 75–82. https://doi.org/10.20473/jfiki.v12i12025.75-82.

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Background: Kratom leaves contain major alkaloid compounds, particularly mitragynine and 7-hydroxymitragynine which have demonstrated anti-pain or analgesic properties. Objective: This study aims to evaluate the effectiveness of kratom leaf extract emulgel in reducing pain when applied topically in mice. Methods: This study was conducted on male mice that had been induced with acetan acid intraperitoneally. Following induction, emulgel formulations were applied topically and pain responses were recorded every five minutes over 30 minutes period. Group 1 (emulgel base without active ingredient)
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15

Shilpa, K. D. *1 Aswathy C. 2. Farhana M. K.3 Hasna E. K. 4. Belna Augustine5. "Emulgel : A Potent Medication Delivery Method." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1066–72. https://doi.org/10.5281/zenodo.12739709.

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These days, emulgels are a common drug delivery technology that are being developed specifically for the administration of hydrophobic medicines. This formulation, which combines gel and emulsion, is thought to be a novel kind of drug delivery method. This review aims to shed light on the emulgel preparation process and their evaluation, ultimately determining the significance of these dosage forms. It will be the most widely utilized in the upcoming years due to its ease of use and ability to improve patient compliance. Emulgels have a long shelf life, are translucent, emollient, easily remov
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16

Bruno, Elisabetta, Francesca Romana Lupi, Domenico Mammolenti, Olga Mileti, Noemi Baldino, and Domenico Gabriele. "Emulgels Structured with Dietary Fiber for Food Uses: A Rheological Model." Foods 11, no. 23 (2022): 3866. http://dx.doi.org/10.3390/foods11233866.

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Emulgels are biphasic emulsified systems in which the continuous phase is structured with a specific gelling agent. In this work, a rheological and microscopic investigation of O/W emulgels prepared by structuring the aqueous (continuous) phase with citrus fiber was carried out with the aim of designing their macroscopic properties for food uses and predicting their characteristics with a rheological model. According to previous investigations, fiber suspensions behave as “particle gels” and, consequently, the derived emulgels’ properties are strongly dependent on the fiber concentration and o
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17

Jagtap, Vaishnavi, Gayatri Jamdade, Tejas Shitole, Vishal Shinde, and Mayuri Shinde. "A Systematic Review on Herbal Emulgel: Formulation, Evaluation, and Antifungal Potential of Lantana Camara Linn Leaves Extract." PDEAS International Journal of Research in Ayurved and Allied Sciences 5, no. 1 (2023): 10–12. https://doi.org/10.63778/pdeasijraas-arjcpl/2023_22810.

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Herbal medicine plays a vital role in modern therapeutic approaches due to its safety and efficacy. The combination of herbal extracts with novel drug delivery systems such as emulgels enhances their therapeutic potential. This review follows the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines to systematically analyze the formulation and evaluation of a herbal emulgel containing Lantana camara Linn leaves extract for antifungal activity. This study critically evaluates the formulation methods, physicochemical properties, and pharmacological efficacy of h
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18

Stolić Jovanović, Aleksandra, Milica Martinović, Ana Žugić, et al. "Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System." Pharmaceutics 15, no. 3 (2023): 813. http://dx.doi.org/10.3390/pharmaceutics15030813.

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The dual controlled release of emulgels makes them efficient drug delivery systems of increasing interest. The framework of this study was to incorporate selected L-ascorbic acid derivatives into emulgels. From the formulated emulgels, the release profiles of actives were evaluated considering their different polarities and concentrations, and consequently their effectiveness on the skin via a long-term in vivo study that lasted for 30 days was determined. Skin effects were assessed by measuring the electrical capacitance of the stratum corneum (EC), trans-epidermal water loss (TEWL), melanin
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19

Patil, Priyanka V., Mala D. Menon, Aparna D. Palshetkar, and Namita D. Desai. "Topical delivery of mupirocin calcium nanostructured lipid carriers using a full-thickness excision wound healing model." Journal of Wound Care 32, Sup5a (2023): lxiii—lxxiv. http://dx.doi.org/10.12968/jowc.2023.32.sup5a.lxiii.

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Objective: Treatment of contaminated wounds represents a significant challenge in healthcare and there is a need to develop approaches maximising skin retention to maintain therapeutic concentrations of anti-infectives at the wound site. The objective of the present study was to develop and evaluate mupirocin calcium nanolipid emulgels to enhance wound healing performance and patient acceptability. Methods: Nanostructured lipid carriers (NLCs) of mupirocin calcium were prepared by the phase inversion temperature method using Precirol ATO 5 (Gattefosse, India) and oleic acid as lipids and Kolli
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Muñoz, José, Paula Prieto-Vargas, Mᵃ Carmen García, and María-Carmen Alfaro-Rodríguez. "Effect of a Change in the CaCl2/Pectin Mass Ratio on the Particle Size, Rheology and Physical Stability of Lemon Essential Oil/W Emulgels." Foods 12, no. 6 (2023): 1137. http://dx.doi.org/10.3390/foods12061137.

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A three-step (rotor-stator-microfluidization-rotor stator) protocol was used to prepare 15% lemon essential oil in water emulgels using a mixture of Tween 80 and Span 20 surfactants as low molecular mass emulsifiers and 0.4% low-methoxyl citrus peel pectin as a gelling agent. Ca2+ was used as a gel-promoting agent. Different CaCl2/pectin mass ratio values from 0.3 to 0.7 were used. Emulgels showed a microstructure consisting of oil droplets embedded in a sheared gel matrix, as demonstrated by bright field optical microscopy. Laser diffraction tests showed multimodal particle size distributions
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SINGH, SHAMBHVI, and INDU SINGH. "EVOLVING IMPLEMENTATION OF EMULGEL AS A TOPICAL DRUG DELIVERY SYSTEM: A SYSTEMATIC REVIEW." Current Research in Pharmaceutical Sciences 12, no. 3 (2022): 121–31. http://dx.doi.org/10.24092/crps.2022.120301.

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Emulgels are a new drug delivery technology for hydrophobic drugs that have received popularity in recent years. This formulation is a blend of emulsion and gel, and it is an innovative type of drug delivery mechanism. The goal of this review is to gain insight into emulgel preparation and evaluation to determine how essential these dosage forms are. It will be widely utilized in the future since it is simple to use and improves patient compliance. Emulgels are readily removed, spreadable, thixotropic, greaseless, pleasant, emollient, have a long shelf life, and are clear. Gels have several ad
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Mirgorodskaya, Alla, Rushana Kushnazarova, Rais Pavlov, et al. "Supramolecular Tools to Improve Wound Healing and Antioxidant Properties of Abietic Acid: Biocompatible Microemulsions and Emulgels." Molecules 27, no. 19 (2022): 6447. http://dx.doi.org/10.3390/molecules27196447.

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Abietic acid, a naturally occurring fir resin compound, that exhibits anti-inflammatory and wound-healing properties, was formulated into biocompatible emulgels based on stable microemulsions with the addition of a carbamate-containing surfactant and Carbopol® 940 gel. Various microemulsion and emulgel formulations were tested for antioxidant and wound-healing properties. The chemiluminescence method has shown that all compositions containing abietic acid have a high antioxidant activity. Using Strat-M® skin-modelling membrane, it was found out that emulgels significantly prolong the release o
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Magre, Saakshi, Rupesh Kumar Jain, Basant Khare, Vivek Jain, and Pushpendra Kumar Khangar. "Formulation and Evaluation of Flurbiprofen Topical Emulgels." International Journal of Medical Sciences and Pharma Research 8, no. 3 (2022): 22–27. http://dx.doi.org/10.22270/ijmspr.v8i3.55.

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Topical drug delivery has been used for centuries for the treatment of local skin disorders. Emulgel have emerged as one of the most interesting topical delivery system as it has dual control release system i.e. gel and emulsion. One side the topical applications of the drug offers the potential advantages of delivering the drug directly to the site of action and secondly delivering the drug for extended period of time at the effected site. Topical non-steroidal anti-inflammatory drug (NSIAD) formulations are designed to deliver therapeutic levels of the active ingredients to the inflamed tiss
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Lilhare, Kajal T., Shilpa S. Borkar, and Jagdish R. Baheti. "Recent Update on Topical Drug Delivery Systems: Emulgel." Asian Journal of Pharmaceutical Research and Development 11, no. 4 (2023): 133–38. http://dx.doi.org/10.22270/ajprd.v11i4.1299.

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Emulgel is an emerging topical drug delivery system that, if more effort is devoted to its formulation and development with more topically active drugs, will prove to be a boon to skin care and cosmetology. Emulgels are both O/W or W/O emulsions which might be gelled with the aid of mixing with a gelling agent. Incorporating the emulgel increases its stability and makes it controlled release system. Due to the lack of excess oil bases and insoluble excipients, it exhibits better drug release compared to other topical drug delivery systems. The presence of the gel phase makes it non-greasy and
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Butkeviciute, Aurita, Kristina Ramanauskiene, and Valdimaras Janulis. "Formulation of Gels and Emulgels with Malus domestica Borkh: Apple Extracts and Their Biopharmaceutical Evaluation In Vitro." Antioxidants 11, no. 2 (2022): 373. http://dx.doi.org/10.3390/antiox11020373.

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Phenolic compounds that estimate apple extracts with multifaceted biological effects are potentially valuable for protection against skin disorders. The purpose of our research was to formulate gels and emulgels containing a complex of phenolic compounds of apple extracts and to perform a biopharmaceutical evaluation of semi-solid pharmaceutical forms, determining their antioxidant activity in vitro. HPLC analyses of phenolic compounds were performed. The total amount of phenolic compounds found in the sample of apples from the ‘Paprastasis antaninis’ cultivar was 1455.5 ± 72.8 µg/g. The relea
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Saxena, Ashwin, Arun K. Mishra, Navneet Verma, et al. "Gelucire BasedIn SituGelling Emulsions: A Potential Carrier for Sustained Stomach Specific Delivery of Gastric Irritant Drugs." BioMed Research International 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/436932.

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Non steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed medications to the geriatric patients for the treatment of arthritis and other painful disorders. The major side effects of NSAIDs are related to their effects on the stomach and bowels. The present study concerns assessment of the potential of liquidin situgelling emulsion formulations (emulgels) as patient compliant stomach specific sustained release carrier for the delivery of highly gastric irritant drug, Piroxicam. Emulgels were prepared, without using any emulgent, by mixing different concentrations of molten Gelucire
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Kola-Mustapha, Adeola Tawakalitu, Miracle Halima Aliu, Ronke Hadiyat Bello, Oluwakorede Joshua Adedeji, and Yusuf Oluwagbenga Ghazali. "The Formulation and Evaluation of Melaleuca alternifolia Cheel and Cymbopogon flexuosus Linn Essential Oils Emulgel for the Treatment of Vulvovaginal Candidiasis." Gels 9, no. 12 (2023): 949. http://dx.doi.org/10.3390/gels9120949.

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The global concern regarding the occurrence of antifungal resistance to synthetic conventional azoles used for treating vulvovaginal candidiasis, along with the associated side effects, is significant. Consequently, the pursuit for substitutes such as natural therapies has ensued. Essential oils, derived from plants, have been extensively researched and found to possess antibacterial and antifungal properties. This study aimed to assess the antifungal efficacy of two essential oils, both alone and in combination, against Candida albicans. Essential oils were formulated into an emulgel separate
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Neacșu, Sorinel Marius, Lucian Hîncu, Lavinia Lia Vlaia, et al. "Eco-Friendly Extraction and Formulation of Black Sea Shark Liver Oil-Based Emulgel for Anti-Inflammatory and Healing Dermatocosmetic Applications." Gels 11, no. 4 (2025): 222. https://doi.org/10.3390/gels11040222.

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This study explores the eco-friendly extraction and formulation of emulgels based on Black Sea shark liver oil for their potential anti-inflammatory and wound healing dermatocosmetic applications. Two emulgel formulations were prepared: Gel 1, containing shark liver oil, and Gel 2, combining shark liver oil with borage oil. The eco-friendly extraction of shark liver oil was performed, yielding a high content of polyunsaturated omega-3 fatty acids, primarily eicosapentaenoic acid (16.68 ± 0.28 mg/g %) and docosahexaenoic acid (18.14 ± 0.31 mg/g %). Physicochemical evaluations of the emulgels re
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Pușcaș, Andreea, Anda Elena Tanislav, Andruța Elena Mureșan, and Vlad Mureșan. "Emulgels as Fat-Replacing Systems in Biscuits Developed with Ternary Mixtures of Pea and Soy Protein Isolates and Gums." Gels 11, no. 7 (2025): 478. https://doi.org/10.3390/gels11070478.

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Hydrogels (Hy) were obtained with a ternary system of proteins (pea (P) or soy isolate (S) 2%), guar (0.5%), and xanthan gums (0.5%) and were subjected to thermal treatment (70 °C/20 min or 85 °C/15 min, or not) prior to structure formation. The FTIR spectra of the hydrogels and the turbidity test (spectrophotometrically red at 600 nm) were used for studying protein–polysaccharide interactions. Amplitude sweeps (0.01–100%) and flow behavior tests (0.1–100 s−1) were conducted for structure analysis. Emulgels were obtained by emulsification of the Hy with 40% or 60% sunflower oil. The centrifuga
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Azam, Faizul, Mohammed H. Alqarni, Sulaiman Mohammed Alnasser, et al. "Formulation, In Vitro and In Silico Evaluations of Anise (Pimpinella anisum L.) Essential Oil Emulgel with Improved Antimicrobial Effects." Gels 9, no. 2 (2023): 111. http://dx.doi.org/10.3390/gels9020111.

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Over the past decade, researchers have made several efforts to develop gel-based formulations that provide an alternative to traditional hydrogels and emulgel. Due to its excellent antibacterial properties, anise, the main constituent of Pimpinella anisum L., widely used in pharmaceuticals, was selected as the active ingredient in this study. Since many bacteria have developed considerable antibiotic resistance, this research aimed to develop an herbal emulgel for treating skin infections caused by bacteria. Given these obstacles, we developed and evaluated a new, cost-effective topical emulge
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31

Mina J. Jabbar and Wedad K. Ali. "An overview of emulgels for topical application." Al Mustansiriyah Journal of Pharmaceutical Sciences 23, no. 3 (2023): 263–72. http://dx.doi.org/10.32947/ajps.v23i3.1043.

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In recent years, gels have been preferentially used for cosmetics and topical pharmaceutical preparations due to their favorable characteristics, such as being greaseless, readily spreadable and easily removable. However, one&#x0D; obstacle that faced it was the inability to enclose hydrophobic compounds. Therefore, a novel approach was developed to circumvent this limitation by mixing the gel with an emulsion, which led to creation of a new topical drug delivery system known as emulgel. Emulgel preserves all favorable features of gel and provides also dual release for drug, thus can be utiliz
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Bagul, Harshada, Vasim Pathan, and Anil Jadhav. "Emulgel - A Novel Advance for Skin Disease." Asian Pacific Journal of Health Sciences 9, no. 2 (2022): 155–61. http://dx.doi.org/10.21276/apjhs.2022.9.2.31.

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A topically applied drug delivery system is used for the direct approach of drugs into the general circulation of the skin. There are many dosage forms to treat dermatological diseases. In that emulgels are recent attention to the scientist, because it has features of both gel and emulsion control release drug delivery system. When gel and emulsion get homogenized together that term is mentioned as emulgel. It is incorporated as a current novel drug delivery system used for topical drug delivery. Emulgels have dual control release mechanism because of the combined features of gel and emulsion.
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Mazurkeviciute, Agne, Inga Matulyte, Marija Ivaskiene, and Modestas Zilius. "Modeling, the Optimization of the Composition of Emulgels with Ciclopirox Olamine, and Quality Assessment." Polymers 16, no. 13 (2024): 1816. http://dx.doi.org/10.3390/polym16131816.

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The design and development of pharmaceutical products require specific knowledge, time, and investment. Response surface methodology (RSM) is a widely used technique in the design of experiments (DoE) to optimize various processes and products. The aim of this study was to model and produce experimental emulgels containing 1% ciclopirox olamine and to evaluate their physical, rheological, and mechanical properties and their ability to release ciclopirox olamine. The objective was to optimize the composition of the experimental emulgel containing 1% ciclopirox olamine by applying a central comp
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34

Ms. N.S.Keerthanadevi, Ms N. S. Keerthanadevi, R. Ashwin R. Ashwin, G. K. Bharathvaj G.K.Bharathvaj, and S. Monisa S.Monisa. "Formulation and evaluation of Ibuprofen Emulgel." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 289–94. https://doi.org/10.35629/4494-1001289294.

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The aim of this study was to formulate and evaluate an emulgel of ibuprofen for enhanced topical delivery and therapeutic efficacy. Emulgels, a combination of emulsions and gels, offer the advantages of both gel and cream forms, providing a smooth, non-greasy texture while facilitating improved drug penetration. Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), was selected due to its widespread use in the treatment of pain and inflammation. Various emulgel formulations were developed using different concentrations of carbopol 940 as a gelling agent, and an oil-in-water emulsion system
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Yadav, Sunil Kumar, Manoj Kumar Mishra, Anupamaa Tiwari, and Ashutosh Shukla. "EMULGEL: A NEW APPROACH FOR ENHANCED TOPICAL DRUG DELIVERY." International Journal of Current Pharmaceutical Research 9, no. 1 (2016): 15. http://dx.doi.org/10.22159/ijcpr.2017v9i1.16628.

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Emulgel is used to treat aches and pains caused by colds, headaches, muscle aches, backaches, arthritis and other conditions and injuries. The patient adherence to topical formulations is significant in relation to chronic skin diseases, like fungal infections, acne, psoriasis. Emulgel is one of the recent technology in NDDS used topically having characteristics of dual control release i.e. emulsion as well as gel. Emulgels have emerged as one of the most interesting topical delivery systems as it has dual release control system i.e. gel and emulsion. When gel and emulsion are used in combined
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36

Ganju, Eisha, Susheel Deshmukh, and Bhaskar Kumar Gupta. "Emulgel Towards Novel Formulation Development: A Comprehensive Review." International Journal of Medical & Pharmaceutical Sciences 14, no. 01 (2024): 01–06. http://dx.doi.org/10.31782/ijmps.2024.14101.

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Emulgels are an innovative topical drug delivery system that combines the properties of emulsions and gels to enhance the delivery and efficacy of pharmaceuticals. These systems leverage the advantages of both components: the solubilizing capabilities of emulsions and the stable, bioadhesive properties of gels. This review aims to summarize the development, formulation strategies, evaluation techniques, and therapeutic applications of emulgels. A comprehensive literature search was conducted across various scientific databases including PubMed, Scopus, and Web of Science. Studies focusing on t
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37

Kola-Mustapha, Adeola Tawakalitu, Haneefat Folashade Ibraheem, Suleiman Taiwo, Ismail O. Ishola, Sukurat Olasumbo Usman, and Yusuf Oluwagbenga Ghazali. "Formulation of Entandrophragma utile into an Herbal Emulgel for the Management of Inflammation." Gels 9, no. 12 (2023): 956. http://dx.doi.org/10.3390/gels9120956.

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Introduction: Globally, the incidence of inflammation and inflammatory disorders has continued to rise at an alarming rate. Entandrophragma utile is a species of flowering plant widely distributed in Africa and has been used for the management of sickle cell disease, rheumatism, ocular inflammation, duodenal and stomach ulcers. This research aims to formulate and evaluate an anti-inflammatory herbal emulgel using an extract from Entandrophragma utile stem bark (EUB). Method: Using a carrageenan-induced paw oedema model, the anti-inflammatory efficacy of EUB the extract was assessed. The formul
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Milutinov, Jovana, Veljko Krstonošić, Dejan Ćirin, and Nebojša Pavlović. "Emulgels: Promising Carrier Systems for Food Ingredients and Drugs." Polymers 15, no. 10 (2023): 2302. http://dx.doi.org/10.3390/polym15102302.

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Novel delivery systems for cosmetics, drugs, and food ingredients are of great scientific and industrial interest due to their ability to incorporate and protect active substances, thus improving their selectivity, bioavailability, and efficacy. Emulgels are emerging carrier systems that represent a mixture of emulsion and gel, which are particularly significant for the delivery of hydrophobic substances. However, the proper selection of main constituents determines the stability and efficacy of emulgels. Emulgels are dual-controlled release systems, where the oil phase is utilized as a carrie
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39

Szymańska, Emilia, Joanna Potaś, Mateusz Maciejczyk, et al. "Preliminary Assessment of Polysaccharide-Based Emulgels Containing Delta-Aminolevulinic Acid for Oral Lichen planus Treatment." Pharmaceuticals 16, no. 11 (2023): 1534. http://dx.doi.org/10.3390/ph16111534.

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Photodynamic therapy using delta-aminolevulinic acid is considered a promising option in the treatment of oral lichen planus. In the present work, three emulgel compositions prepared from natural polysaccharide gums, tragacanth, xanthan and gellan, were preliminarily tested for oromucosal delivery of delta-aminolevulinic acid. Apart from cytotoxicity studies in two gingival cell lines, the precise goal was to investigate whether the presence of the drug altered the rheological and mucoadhesive behavior of applied gelling agents and to examine how dilution with saliva fluid influenced the reten
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40

Grela, Kamil P., Dominik M. Marciniak, and Bożena Karolewicz. "Poloxamer 407-Based Thermosensitive Emulgel as a Novel Formulation Providing a Controlled Release of Oil-Soluble Pharmaceuticals—Ibuprofen Case Study." Materials 14, no. 23 (2021): 7266. http://dx.doi.org/10.3390/ma14237266.

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This article covers the design and evaluation of a novel drug vehicle: a thermosensitive, injectable, high-oil-content (50% w/w) emulgel providing a controlled release of lipophilic pharmaceuticals. Different vegetable (castor, canola, olive, peanut, grapeseed, linseed), mineral (paraffin) and semisynthetic (isopropyl myristate, oleic acid) oils were screened for ibuprofen (IBU) solubility and for their capacity for high-shear emulsification in a 17% (w/w) aqueous solution of poloxamer 407. Chosen emulgels were subject to a rheological evaluation, a syringeability test (TA.XT texture analyser;
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41

Aji, Nur, Arum Puspitasari, Haevia Nafisah, and Levina Hadi Vania Armilda. "Antioxidant and Anti-Propionibacterium acnes Activities of Citronella Oil and Clove Oil, and their Formulation Into Emulgel." PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) 20, no. 1 (2023): 64. http://dx.doi.org/10.30595/pharmacy.v0i0.12629.

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Propionibacterium acnes is a common acne-causing bacteria in adolescents and adults. The combination of citronella oil and clove oil has the potential to inhibit the growth of Propionibacterium acnes. Both essential oils are also known to have antioxidant effects. The combination of the two essential oils is expected to have better activity. The purpose of this research was to determine the activity of the Fractional Inhibitory Concentration (FIC) index against Propionibacterium acnes, antioxidant activity, and formulation in emulgel. Antibacterial assay of combination citronella oil and clove
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42

Narendra, Umale* S. Wankhade Minakshi Hingane Samiksha Kathane Shravani Kadu Dr. H. S. Sawarkar. "Emulgel and Nano Emulgel as Topical Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 580–604. https://doi.org/10.5281/zenodo.14622532.

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Emulgel is an innovative drug delivery system that combines the advantages of both emulsions and gels, offering a promising approach for enhanced topical drug delivery. This unique formulation integrates oil-in-water or water-in-oil emulsions into a gel base, enabling superior penetration of active pharmaceutical ingredients through the skin. The emulgel system enhances the solubility and bioavailability of lipophilic drugs, making it an ideal candidate for topical applications in dermatology, pain management, and anti-inflammatory treatments. Its dual-phase structure allows for controlled dru
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43

Aditi Anand Kasture, Vaishnavi Shrinivas Gone, and Rakesh Rajshekhar Gore. "Eucalyptus emulgel: A novel formulation with analgesic properties." World Journal of Biology Pharmacy and Health Sciences 19, no. 1 (2024): 044–54. http://dx.doi.org/10.30574/wjbphs.2024.19.1.0394.

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Emulgels have emerged as a promising topical drug delivery system for the delivery of hydrophobic drug via skin. The objective of the study was to prepare eucalyptus emulgel. When we are preparing a emulsion individually shows stability problems during manufacturing and storage that effects on drug release pattern. In order to increase the drug stability, we incorporate it as emulgel. Emulgel is a thermodynamically stable formulation with low interfacial tension that is made by combining a surfactant and a co-surfactant and has several properties such as increased permeability and good thermod
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44

Aditi, Anand Kasture, Shrinivas Gone Vaishnavi, and Rajshekhar Gore Rakesh. "Eucalyptus emulgel: A novel formulation with analgesic properties." World Journal of Biology Pharmacy and Health Sciences 19, no. 1 (2024): 044–54. https://doi.org/10.5281/zenodo.13788188.

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Emulgels have emerged as a promising topical drug delivery system for the delivery of hydrophobic drug via skin. The objective of the study was to prepare eucalyptus emulgel. When we are preparing a emulsion individually shows stability problems during manufacturing and storage that effects on drug release pattern. In order to increase the drug stability, we incorporate it as emulgel. Emulgel is a thermodynamically stable formulation with low interfacial tension that is made by combining a surfactant and a co-surfactant and has several properties such as increased permeability and good thermod
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45

Sah, Shailendra Kumar, Ashutosh Badola, and Bipin Kumar Nayak. "Emulgel: Magnifying the application of topical drug delivery." Indian Journal of Pharmaceutical and Biological Research 5, no. 01 (2017): 25–33. http://dx.doi.org/10.30750/ijpbr.5.1.4.

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Topical drug delivery is mostly culled for the local dermatological action, but recently the new technologies are also enhancing its systemic effect. They are generally applied for the purpose as antiseptics, antifungal agents, skin emollients, and protectants. The activity of topical preparation confide in the various factors as drug solubility, its lipophilicity, contact time to skin, its permeability. Many widely used topical agents like ointments, creams, lotions, gel are associated with disadvantages like stability problems, stickiness and lesser spreading coefficient, irritation, allergi
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46

Szymańska, Emilia, Joanna Potaś, Marcin Baranowski, et al. "Evaluation of Oromucosal Natural Gum-Based Emulgels as Novel Strategy for Photodynamic Therapy of Oral Premalignant Lesions." Pharmaceutics 15, no. 10 (2023): 2512. http://dx.doi.org/10.3390/pharmaceutics15102512.

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Photodynamic therapy (PDT) recently has been shown as a promising option in the treatment of premalignant lesions of the soft oral tissues. Effective delivery of photosensitizer is challenging due to poor drug adherence to the oromucosal epithelium. In the present work, emulgels composed of natural polysaccharide gums (tragacanth, xanthan and gellan) were evaluated as novel oromucosal platforms of delta-aminolevulinic acid (ALA) for PDT. Apart from mucoadhesive and textural analysis, the specific steps involved studies on drug penetration behavior and safety profile using a three-dimensional h
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47

Chaitanya, V. Pawar Nishant V. Pote Munjaji M. Mule Rohini B. Chougale Ms. Wale R.R. "A Review On: Formulation And Estimation Of Topical Emulgel." International Journal of Pharmaceutical Sciences 2, no. 6 (2024): 602–9. https://doi.org/10.5281/zenodo.11582581.

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Many advantages of gels a major limitation is in the delivery of hydrophobic drugs. So to overcome this limitation an emulsion based approach is being used so that even a hydrophobic therapeutic moiety can enjoy the unique properties of gels. When gels and emulsions are used in combined form the dosage form are referred as emulgel. In recent years, there has been great interest in the use of novel polymers. A unique aspect of dermatological pharmacology is the direct accessibility of the skin as a target organ for diagnosis and treatment. The combination of hydrophilic cornified cells in hydro
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48

Cheng, Ce, Yi Gao, Zhihua Wu та ін. "Gliadin Nanoparticles Pickering Emulgels for β-Carotene Delivery: Effect of Particle Concentration on the Stability and Bioaccessibility". Molecules 25, № 18 (2020): 4188. http://dx.doi.org/10.3390/molecules25184188.

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β-carotene is a promising natural active ingredient for optimum human health. However, the insolubility in water, low oral bioavailability, and instability in oxygen, heat, and light are key factors to limit its application as incorporation into functional foods. Therefore, gliadin nanoparticles (GNPs) Pickering emulgels were chosen as food-grade β-carotene delivery systems. The objectives of the present study were to investigate the influence of GNPs concentration on the rheological properties, stability, and simulated gastrointestinal fate of β-carotene of Pickering emulgels. The formulation
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Mahajan, Vijay Rajaram, and Ganesh Dinkar Basarkar. "Formulation design, development and characterization of dexibuprofen emulgel for topical delivery: In-vitro and In-vivo evaluation." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 330–42. http://dx.doi.org/10.22270/jddt.v9i2-s.2711.

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Emulgels have emerged as a promising drug delivery system for the delivery of hydrophobic drugs. The objective of the study was to prepare emulgel of Dexibuprofen, a NSAID, using Carbapol 940 as a gelling agent. Clove oil and Mentha oil were used as penetration enhancers. The emulsion was prepared and it was added in gel base. The formulations were evaluated for rheological studies, spreading coefficient studies, bioadhesion strength, skin irritation studies, in vitro release, ex vivo release studies, anti-inflammatory activity and analgesic activity. Formulation showed comparable analgesic an
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Kancharla, Kameswararao* Dr Md Abdul Sattar Chintakayala Sairam Inakoti Siva Sankara Vara Prasad N. M. S. Narayana Murthy. "A Brief Review on Emulgels." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 1628–38. https://doi.org/10.5281/zenodo.14244530.

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Topical drug delivery system is good drug delivery system, in which drug directly contact with skin produces its pharmacological effect to targeted site to cure and treat various disorder. Emulgels is an emerging topical drug delivery system that will prove boon to skin care and cosmetology. Emulgels are prepared by the incorporation of the emulsion into the gel with constant stirring at a moderate speed. Emulsions are either available in an oil in water or water in oil type. Incorporation of emulsion into a gel makes it a dual control release system, increasing its stability and provides bett
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