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Dissertations / Theses on the topic 'Enantiomer separation'

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Published: 4 June 2021

Last updated: 9 February 2022

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1

Fraunholz, Thomas [Verfasser], and R. H. W. [Akademischer Betreuer] Hoppe. "Transport at Interfaces in Lipid Membranes and Enantiomer Separation / Thomas Fraunholz. Betreuer: R. H. W. Hoppe." Augsburg : Universität Augsburg, 2015. http://d-nb.info/1077705638/34.

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2

Bao, Ye. "Enantiomeric separations and microorganism studies with analytical separation techniques." [Ames, Iowa : Iowa State University], 2008.

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3

Wildervanck, Alexander Franciscus. "Separation of enantiomers of Baclofen." Master's thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/20462.

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(3-(Aminomethyl)-4-chlorobenzenepropanoic acid (Baclofen), 3-(p-chlorophenyl)pyrrolidone (Baclofen lactam) and 3-(p-Chlorophenyl)glutaramide (baclofen's synthetic precursor) were individually used as substrates in co-crystallisation experiments with several resolving agents. Experiments were conducted in the solid state and in solution. The (-) enantiomer of the lactam and the ( +) enantiomer of the glutaramide were found to cocrystallise selectively with (2R,3R)-( +)-tartaric acid and (S)-(-)-a.-Methylbenzylamine respectively. Both these dissociable diastereomers Vere analysed by X-ray crysta

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4

Oliveira, Elder Gonçalves de. "Desenvolvimento e validação de métodos analíticos para a análise enantiomérica da duloxetina e de sua impureza quiral em formulação farmacêutica." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/139442.

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A duloxetina é um potente inibidor duplo da recaptação de serotonina e norepinefrina, disponível como enantiômero puro, sob a forma S-duloxetina e comercializado como pellets em cápsulas. O R enantiômero da duloxetina é também um inibidor da recaptação, no entanto, este é menos potente que seu isômero, sendo considerado como impureza enantiomérica. Este trabalho teve como objetivos o desenvolvimento e a validação de métodos analíticos para o controle de qualidade da duloxetina e de sua respectiva impureza enantiomérica por cromatografia líquida de alta eficiência (CLAE), e por eletroforese cap

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5

Barros, Georgia de Oliveira Figueiredo. "Resolução de misturas racemicas por acoplamento de cristalização a cromatografia em leito movel simulado : estudos fundamentais para a produção de S-cetamina." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267314.

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Orientador: Everson Alves Miranda<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica<br>Made available in DSpace on 2018-08-04T07:13:28Z (GMT). No. of bitstreams: 1 Barros_GeorgiadeOliveiraFigueiredo_M.pdf: 2282903 bytes, checksum: b104323f697a813ec6af57b15ba7b95b (MD5) Previous issue date: 2005<br>Resumo: A separação de enantiômetros em altos níveis de pureza enantiomérica é atualmente um requerimento da industria farmacêutica. No entanto, altas purezas estão sendo alcançadas neste sistema com comprometimento da produtividade. O acoplamento do lei

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6

Chatah, Nour-El-Houda. "Apports de la cristallisation aux dédoublements d'espèces chirales." Rouen, 1996. http://www.theses.fr/1996ROUES032.

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Le comportement stéréospécifique des espèces organiques chirales impose le dédoublement du mélange racémique. La cristallisation fractionnée de sels diastéréoisomères est un protocole qui concerne près de 65 % des produits pharmaceutiques. L'intervention de l'agent chiral de dédoublement vérifiant la stoechiométrie pastorienne peut être fortement limitée en opérant en présence d'un agent achiral et réduisant ainsi le coût de la production. Le mélange en milieu éthanolique conduit à un système thermodynamique relevant d'un quaternaire réciproque. Le système met en jeu les (1R, 3S)-(+)-camphorat

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7

Elgarhy, Karim. "The separation of the enantiomers of asparagine by crystallization /." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100356.

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Enantiomers are chiral molecules (i.e. they are mirror-images of each other). They have identical physical properties except for the rotation of polarized light. However their chemical properties are different when reacting with other chiral molecules. The majority of biological processes involve the reaction of two or more chiral molecules. There is therefore a strong interest coming from the pharmaceutical, food and agricultural industry for the separation of enantiomers.<br>Separation methods such as chromatography exist but are generally expensive and limited in scale. Stereosynthesis ofte

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8

Meeson, Stephen Russell. "The separation of enantiomers by high performance liquid chromatography." Thesis, University of Newcastle Upon Tyne, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278414.

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9

Rocco, Anna. "Separation of Enantiomers by Means of NanoO-Liquid Chromatography." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2013~D_20130122_144808-59559.

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Nano-liquid chromatography (nano-LC) was selected as analytical tool to develop different methods for chiral separations. Nano-LC offers several advantages over conventional LC, e.g., low sample requirement, short analysis time, easy coupling with mass spectrometer, and use of small amount of reagents, with a consequent low environmental pollution. In case of chiral separations, where expensive chiral stationary phases or chiral mobile phase additives (CMPA) have to be employed, nano-LC results very useful since it allows to perform analysis with small amount of this costly material. Initiall

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10

Haglöf, Jakob. "Enantiomeric Separations using Chiral Counter-Ions." Doctoral thesis, Uppsala universitet, Avdelningen för analytisk farmaceutisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-130049.

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This thesis describes the use of chiral counter-ions for the enantiomeric separation of amines in non-aqueous capillary electrophoresis. The investigations have been concentrated on studies of the influence, of the chiral counter-ion, the solvent, the electrolyte and the analyte, on the enantioselective separation. Modified divalent dipeptides have been introduced in capillary electrophoresis for the separation of amino alcohols and chiral resolution of amines. Association constants for the ion-pair between dipeptide and amino alcohol could be utilized for development of separation systems wit

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11

Sebogisi, Baganetsi Karabo. "Separation of racemates via host-guest chemistry." Thesis, Cape Peninsula University of Technology, 2012. http://hdl.handle.net/20.500.11838/730.

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Thesis submitted in fulfilment of the requirements for the degree Magister Technologiae: Chemistry in the Faculty of Applied Science at the CAPE PENINSULA UNIVERSITY OF TECHNOLOGY 2012<br>Chirality is very important to the pharmaceutical industry as enantiomers have the same macroproperties except for their optical and pharmacological activity. Industrial research has thus focused to find the most effective resolution technique. However, our aim was to obtain more information regarding the discrimination process. In this project the structures of the hydrates of di-quininium L-malate, (2QUIN+)

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12

Nzeadibe, Kingsley C. I. "Synthesis of new, single-isomer quaternary ammonium derivatives of beta-cyclodextrin for electrophoretic enantiomer separations." Texas A&M University, 2003. http://hdl.handle.net/1969.1/5833.

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The isolation of individual enantiomers of drugs is an important subject of interest in the pharmaceutical and medical fields, because stereochemistry can have a significant effect on the biological activity of the drug. Therefore, it is important to develop enantiomeric separation methods for the determination of the optical purity of drugs, since the undesired enantiomer is regarded as one of the impurities. The available single isomer anionic cyclodextrins (CD) can resolve the enantiomers of only a few weakly acidic analytes. To rectify this problem, the chloride salts of heptakis(6-deoxy-6

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13

Pinto, José Jorge Baeta Fontinha. "One-pot enzymatic resolution/separation of enantiomers using green solvents." Master's thesis, Faculdade de Ciências e Tecnologia, 2013. http://hdl.handle.net/10362/10824.

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Dissertação para obtenção do Grau de Mestre em Biotecnologia<br>In the context of “green” chemistry and sustainable processes, the main goal of this work is to develop a process that would circumvent the current complications of racemic sec-alcohol separation, using alternative solvents and selective enzymatic resolution. In this work the ability of enzymes to perform the resolution of sec-alcohols to obtain high added-value enantiomers is advantageously exploited in the production of pure chiral compounds. Candida rugosa lipase is capable of selectively converting one of the enantiomers of

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14

Dvořák, Miloš. "Posouzení aplikovatelnosti nepřímé fotometrické detekce k chirálním separacím vybraných karboxylových kyselin v mlékárenských výrobcích." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2009. http://www.nusl.cz/ntk/nusl-216563.

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In this diploma work is check possibility application indirect photometric detection for enantiomers separation lactic acids and beta-hydroxybutyric acid with capillary electrophoresis. As chiral selector is used vankomycin. Verifyed his ability partial separation lactic acid on antipode with using picric acid as vizualition anion in background electrolyte. Used was coated capillary. Application indirect photometric detection succeed. Chiral separation beta-hydroxybutyric acid wasn't successful. Hip roll by selection fit vizualization anions for purposes indirect photometric detection. Are mea

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15

Wu, Zecai. "Enantiomeric purity determination using dual polarimetric and absorbance detection." Thesis, University of York, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306467.

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16

Alcala, Saavedra Monica. "Design of solid state composites for enantiomeric separations /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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17

Rimmer, Duncan Adam. "Novel asymmetric microenvironments for separation of enantiomers chiral drugs and natural products." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254965.

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18

Fernandes, Andreia Patrícia Macedo. "Separation of mandelic acid enantiomers using aqueous biphasic systems containing chiral selectors." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22869.

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Mestrado em Bioquímica - Métodos Biomoleculares<br>A quiralidade é a uma propriedade importante na indústria farmacêutica, uma vez que um enantiómero de um fármaco pode exercer o efeito terapêutico desejado enquanto o outro pode ser inerte ou mesmo nefasto. Embora vários fármacos sejam comercializados na sua forma racémica, as entidades regulatórias aconselham o desenvolvimento de fármacos enantiomericamente puros e mais seguros. Neste contexto, a indústria farmacêutica procura formas baratas e eficientes de produzir fármacos enantiomericamente puros, sendo este o objetivo da presente tese. A

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19

Thome, Brian Matthew. "Increasing the scale of electrophoretic true moving bed enantiomer separations using voltage gradients and filtration enhancement." Online access for everyone, 2006. http://www.dissertations.wsu.edu/Dissertations/Fall2006/b_thome_110706.pdf.

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20

Wong, Kim Kai Wai. "Synthesis of silicon functionalised cyclic peptides for enantiomeric separations." Thesis, University of Bath, 1990. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278284.

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21

Borgsmiller, Karen McNeal. "Synthetic membranes for chiral separations." Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/11824.

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22

Kaspereit, Malte [Verfasser]. "Separation of Enantiomers by a Process Combination of Chromatography and Crystallisation / Malte Kaspereit." Aachen : Shaker, 2006. http://d-nb.info/1170530893/34.

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23

Yeung, Kai Tai. "Molecular simulations of the enantioseparating mechanism of polysaccharide-based chiral stationary phase and enzymatic acylation of N-benzoyl-L-arginine ethyl ester in binary aquo-organic solvent mixtures." HKBU Institutional Repository, 2007. http://repository.hkbu.edu.hk/etd_ra/819.

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24

Li, Xiaoping. "Thermodynamic and kinetic characterization of chiral separations with ß-cyclodextrin stationary phase." Diss., Connect to online resource - MSU authorized users, 2006.

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25

Li, Song 1957. "Liquid chromatographic separation of enantiomers and structurally-related compounds on b-cyclodextrin stationary phases." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70269.

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The retention behaviour of 16 phenothiazines and structurally-related drugs on a $ beta$-cyclodextrin-bonded phase column was studied with respect to pH, mobile phase composition and column temperature. Both isocratic and gradient-elution separations of these compounds were investigated.<br>The enantiomers of twelve racemic dinitrophenyl amino acid derivatives were separated on a $ beta$-cyclodextrin-bonded phase column. The effects of pH, methanol and triethylammonium acetate (TEAA) buffer concentrations on the retention and resolution were investigated. The chiral recognition mechanism was s

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26

Munkelt, Thomas [Verfasser], and Andreas [Gutachter] Seidel-Morgenstern. "Separation, Speicherung und Gewinnung der Enantiomere chiraler Anästhetika / Thomas Munkelt ; Gutachter: Andreas Seidel-Morgenstern." Magdeburg : Universitätsbibliothek Otto-von-Guericke-Universität, 2019. http://d-nb.info/1219937061/34.

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27

Maldonado, Omar. "Synthesis of charged cyclodextrin highly soluble in organic solvents for enantiomer separations in capillary electrophoresis." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4211.

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Synthesis of charged cyclodextrin highly soluble in organic solvents was made by exchanging the inorganic counter ion (Na+) of heptakis (2,3-di-Omethyl- 6-O-sulfo)-ÃÂ²-CD (Na7HDMS) with tetrabutylammonium (TBA+), to produce TBA7HDMS. The same ion exchange was used to synthesize the TBA salts of the analogous CDs TBA6HxDMS and TBA8ODMS. Indirect-UV detection capillary electrophoresis (CE) and 1H NMR were used as the characterization methods. Separations of thirteen pharmaceuticals were made using TBA7HDMS as the chiral resolving agent in aqueous CE. On the other hand, a set of twenty pharmaceu

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28

Wang, Min. "Novel applications of comprehensive two-dimensional gas chromatography and capillary electrophoresis for the chiral discrimination." HKBU Institutional Repository, 2007. http://repository.hkbu.edu.hk/etd_ra/823.

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29

Hedeland, Ylva. "Chiral Separation of Amines by Non-Aqueous Capillary Electrophoresis using Low Molecular Weight Selectors." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6759.

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30

Klute, Robert Cragg. "Enantiomeric separations by HPLC : temperature, mobile phase, flow rate and retention mechanism studies /." This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-06062008-171241/.

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31

Witte, Dirk Theodoor. "High performance liquid chromatography for direct and indirect enantiomeric separations of chiral drugs." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1992. http://irs.ub.rug.nl/ppn/297969609.

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32

Klute, Robert Cragg. "Enantiomeric separations by HPLC:temperature, mobile phase, flow rate and retention mechanism studies." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/38458.

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The effects of changes in temperature, mobile phase composition, flow rate, and stationary phase upon the enantiomeric separation of several racemic mixtures are investigated. The changes in capacity factor (k'), selectivity (α), and efficiency (N) and enantiomeric resolution (R), are explored. Resolution is then shown to be controlled by the specific combination of chiral stationary phase (CSP), solute, mobile phase and temperature. The key to optimizing chiral resolution lies in understanding the retention mechanism(s) for a given CSP. The proposed retention mechanisms for the two CSP used

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33

Crawford, Andrew John. "A study of carbohydrate stationary phases for the separation of enantiomers by high performance liquid chromatography." Thesis, University of Warwick, 1993. http://wrap.warwick.ac.uk/34638/.

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The relationship between the structure and chromatographic properties of silica is discussed and the preparation and properties of chemically-bonded stationary phases based on silica are reviewed. A detailed account is given of the history of the development of carbohydrate-based stationary phases, including microcrystalline cellulose, other polysaccharides and monosaccharides and their ester and carbamate derivatives, with emphasis on their utility for the chromatographic resolution of enantiomers. Mechanisms of chiral discrimination by these and other types of chiral HPLC phases are discusse

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34

Sanchez, Vindas Silvia Elena. "Non-aqueous, capillary electrophoretic separations of enantiomers with a charged cyclodextrin highly-soluble in organic solvents." Thesis, Texas A&M University, 2004. http://hdl.handle.net/1969.1/2742.

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The synthesis of the sodium salt of heptakis (2, 3-di-O-acetyl-6-O-sulfo)-β-cyclodextrin was modified to increase the isomeric purity to 98.5%. This salt was used to obtain the organic-solvent-soluble, single-isomer, charged tetrabutylammonium salt of heptakis (2, 3-di-O-acetyl-6-O-sulfo)-β-cyclodextrin. Its isomeric purity was higher than 99%, as determined by CE, and its structure was confirmed by NMR and ESI-MS analysis. The hydrophobic single-isomer cyclodextrin was utilized to separate the enantiomers of weak base analytes in aprotic media by capillary electrophoresis. The effective mo

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35

Han, Jeong Woo. "Density functional theory studies for separation of enantiomers of a chiral species by enantiospecific adsorption on solid surfaces." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34848.

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The distinct response of biological systems to the two enantiomers of a chiral chemical has led to a large market for enantiopure pharmaceuticals and raised fundamental issues about the origin of biological homochirality. It is therefore important to understand the interactions of chiral molecules with chiral environments. Chiral environments associated with solid surfaces could potentially play a useful role in chirally specific chemical processing. There are a variety of routes for creating chiral solid surfaces. Surfaces of materials whose bulk crystal structure is enantiomorphic can be use

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36

Busby, Michael Brent. "Two new, single-isomer, sulfated β-cyclodextrins for use as chiral resolving agents for enantiomer separations in capillary electrophoresis." Texas A&M University, 2005. http://hdl.handle.net/1969.1/3737.

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Two novel, single-isomer, sulfated cyclodextrins, the sodium salts of heptakis(2- O-methyl-3-O-acetyl-6-O-sulfo)cyclomaltoheptaose (HMAS) and heptakis(2-O-methyl- 6-O-sulfo)cyclomaltoheptaose (HMS) were used as chiral resolving agents in both aqueous and non-aqueous electrophoretic separation of a set of pharmaceutically active weak base enantiomers. Enantiomers of twenty one of the twenty four weak bases were baseline resolved in one or more of the background electrolytes (BGEs) used. An eight-step synthetic method was used to produce, on a large scale, the title compounds in greater th

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37

Yan, Jinglan. "Sulfated ß-cyclodextrins in enantiomeric separations and mobility conservation model in cyclodextrin-mediated capillary electrophoresis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ35009.pdf.

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38

Cannes, Mélanie. "Séparation énantiomérique : utilisation des cyclodextrines en chromatographie liquide chirale." Paris 5, 1996. http://www.theses.fr/1996PA05P195.

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39

Li, Shulan. "Synthesis, characterization and capillary electrophoretic use of new, single-isomer hexasulfated alpha-cyclodextrins." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/2200.

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The first three, pure, single-isomer, 6-O-sulfo a-cyclodextrins, the sodium salts of hexakis(6-O-sulfo)-a-CD (HxS), hexakis(2,3-di-O-methyl-6-O-sulfo)-a-cyclodextrin (HxDMS) and hexakis(2,3-di-O-acetyl-6-O-sulfo)-a-cyclodextrin (HxDAS) have been synthesized, analytically characterized and utilized as chiral resolving agents in capillary electrophoresis. The purity of each synthetic intermediate and of the final product was determined by HPLC-ELSD and indirect UV-detection capillary electrophoresis. The structural identity of each intermediate and final product was verified by 1D and 2D NMR, an

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40

Tam, Le Minh [Verfasser]. "Designing crystallization based-enantiomeric separation for chiral compound-forming systems in consideration of polymorphism and solvate formation / Le Minh Tam." München : Verlag Dr. Hut, 2014. http://d-nb.info/1052374735/34.

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41

[Verfasser], Le-Minh-Tam. "Designing crystallization based-enantiomeric separation for chiral compound-forming systems in consideration of polymorphism and solvate formation / Le Minh Tam." München : Verlag Dr. Hut, 2014. http://nbn-resolving.de/urn:nbn:de:101:1-2014062022375.

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42

Lodén, Henrik. "Separation of Pharmaceuticals by Capillary Electrophoresis using Partial Filling and Multiple-injections." Doctoral thesis, Uppsala universitet, Avdelningen för analytisk farmaceutisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8841.

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Different multiple-injection methodologies and the partial filling technique (PFT) have been utilized for separation of pharmaceuticals by capillary elec-trophoresis. In multiple-injection capillary zone electrophoresis (MICZE), the samples and all standards, used for construction of the calibration curve, are analyzed within a single run. Four different modes of MICZE have been described by means of equations, which were experimentally verified. The developed equations facilitate the transfer from conventional single-injection CZE to one or more of these MICZE-modes, depending on the selectiv

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43

Han, Xinxin. "Enantiomeric separations on cyclodextrin-based and synthetic polymeric chiral stationary phases by high performance liquid chromatography and supercritical fluid chromatography." [Ames, Iowa : Iowa State University], 2007.

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44

Warnke, Molly Melissa. "Enantiomeric separations of natural compounds and metal complexes and the detection of anions using positive mode electrospray ionization mass spectrometry." [Ames, Iowa : Iowa State University], 2008.

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45

Freitas, Alessandra Ferraiolo de. "Caracterização e aplicação da fase estacionaria quiral tris(3,5-dimetilfenilcarbamato) de amilose na separação preparativa dos enantiomeros do omeprazol." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267135.

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Orientadores: Cesar Costapinto Santana, Quezia Bezerra Cass<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica<br>Made available in DSpace on 2018-08-13T23:12:40Z (GMT). No. of bitstreams: 1 Freitas_AlessandraFerraiolode_D.pdf: 3156949 bytes, checksum: bbcb73e35f211a07f6b4ff3c0740867c (MD5) Previous issue date: 2009<br>Resumo: O objetivo deste trabalho foi a síntese, em larga escala, da fase estacionária quiral tris(3,5-dimetilfenilcarbamato) de amilose e posterior investigação desta na separação preparativa dos enantiômeros do omeprazol por cromatografi

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46

Végvári, Ákos. "True Monoliths as Separation Media : Homogeneous Gels for Electrophoresis and Electrochromatography in the Capillary and Microchip Modes." Doctoral thesis, Uppsala University, Department of Biochemistry, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2584.

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<p>The thesis focuses on the development of new homogeneous gels for the separation of drug enantiomers, peptides, DNA and virus by electrophoresis and electrochromatography in capillaries and microchips. This type of separation media offers high resolution and small zone broadening. Compared to particulate beds the resolution in this type of separation media is high because the eddy diffusion is zero and the resistance to mass transfer is small, since the diffusional distance between two polymer chains in the gel is considerably shorter than that between two beads in a packed bed.</p><p>The g

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47

Rosa, Paulo César Pires 1976. "Estudo da separação cromatografica dos enantiomeros do omeprazol em fase estacionaria quiral Kromasil CHI-TBB (0,0' - BIS[4-TERC-BUTILBENZOIL] -N,N'-DIALIL-L-TARTADIAMIDA)." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/266154.

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Orientador: Cesar Costapinto Santana<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica<br>Made available in DSpace on 2018-08-04T05:30:38Z (GMT). No. of bitstreams: 1 Rosa_PauloCesarPires_M.pdf: 3974194 bytes, checksum: 1c2d85f684175c77a00725571c9e316c (MD5) Previous issue date: 2005<br>Resumo: O fármaco racêmico omeprazol tem sido utilizado no tratamento de doenças relacionadas à acidez gástrica e apresenta atividades diferentes entre os enantiômeros. O enantiômero S, conhecido como esomeprazol, tem maior atividade quanto à inibição da secreção g

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Albuquerque, Nayara Cristina Perez de. "Avaliação de fungos no metabolismo enantiosseletivo da Zopiclona e análise por eletroforese capilar." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/59/59138/tde-29102014-093152/.

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A zopiclona (ZO) é um fármaco quiral extensivamente metabolizado em N-desmetilzopiclona (N-Des) e zopiclona-N-óxido (N-Ox). A (S)-N-Des apresenta atividade ansiolítica, o que indica que este metabólito possui potencial para ser empregado no tratamento da ansiedade. Uma alternativa para obtenção deste metabólito pode ser a biotransformação empregando fungos como agentes catalisadores. Dessa forma, o objetivo desse trabalho foi avaliar o potencial de fungos em realizar o metabolismo da ZO em seu metabólito N-Des assim como verificar a enantiosseletividade desse processo. A análise da ZO e seus m

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[Verfasser], Le-Minh-Tam, and Andreas [Akademischer Betreuer] Seidel-Morgenstern. "Designing crystallization based-enantiomeric separation for chiral compound-forming systems in consideration of polymorphism and solvate formation / Tam Le Minh. Betreuer: Andreas Seidel-Morgenstern." Magdeburg : Universitätsbibliothek, 2014. http://d-nb.info/105791391X/34.

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Silverio, Vivian Alves. "Separação, obtenção e utilização de enantômeros puros no controle estereoespecífico de qualidade de medicamentos contendo bisoprolol." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-08032013-162959/.

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A diferença na atividade terapêutica, farmacocinética e / ou farmacodinâmica entre os enantiômeros de fármacos quirais impulsionou a necessidade de estudar e desenvolver métodos para determinação exata e precisa da pureza enantiomérica dos produtos farmacêuticos. Inicialmente, os enantiômeros foram separados em escala analítica. As condições analíticas foram adaptadas para a escala semi-preparativa para a obtenção enantiômeros puros. Os enantiômeros do bisoprolol foram separados através de Cromatografia Líquida de Alta Eficiência. Foi adotado o sistema direto de separação, fase normal, utiliza

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