Academic literature on the topic 'Enantiomers'

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Journal articles on the topic "Enantiomers"

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Laldinchhana, Judy Lalrengpuii, Lobsang Tenzing Komu, and Probin Kr Roy. "Enantioselectivity in Pharmacokinetics: A Mini Review." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 17, no. 6 (2024): 7736–45. https://doi.org/10.37285/ijpsn.2024.17.6.11.

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Enantiomerism or drug chirality is one of the major concerns in drug discovery and development since more than 50% of currently marketed drugs are chiral compounds. Chiral molecules are also called enantiomers where a molecule contains at least one asymmetric carbon. Chiral inversion is an important phenomenon in which an enantiomer may convert from one enantiomeric configuration to the other which can be unidirectional or bidirectional. Enantiomers, though similar in their chemical structure, show noticeable differences in their biological properties. Therefore, a thorough knowledge of racemi
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Zhou, Juan, Qiao Chen, Li-lan Wang, Yong-hua Wang, and Ying-zi Fu. "Chiral Discrimination of Tryptophan Enantiomers via (1R, 2R)-2-Amino-1, 2-Diphenyl Ethanol Modified Interface." International Journal of Electrochemistry 2011 (2011): 1–6. http://dx.doi.org/10.4061/2011/502364.

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The paper reported that a simple chiral selective interface constructed by (1R, 2R)-2-amino-1, 2-diphenyl ethanol had been developed to discriminate tryptophan enantiomers. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used for the characteristic analysis of the electrode. The results indicated that the interface showed stable and sensitive property to determine the tryptophan enantiomers. Moreover, it exhibited the better stereoselectivity for L-tryptophan than that for D-tryptophan. The discrimination characteristics of the chiral selective interface for discr
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Coles, Simon, David Davies, Michael Hursthouse, Serkan Yeşilot, Bünyemin Çoşut, and Adem Kılıç. "Absolute structure determination as a reference for the enantiomeric resolution of racemic mixtures of cyclophosphazenes via chiral high-performance liquid chromatography." Acta Crystallographica Section B Structural Science 65, no. 3 (2009): 355–62. http://dx.doi.org/10.1107/s0108768109006120.

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Reversed-phase chiral high-performance liquid chromatography (HPLC) is a potentially powerful technique for the enantiomeric resolution of racemic mixtures, although the elution order of enantiomers is only relative and it is necessary to fully characterize reference systems for this method to provide absolute configurational information. The enantiomeric resolution of a series of racemic di-spiro cyclotriphosphazene derivatives, N3P3 X 2[O(CH2)3NH]2 (X = Cl, Ph, SPh, NHPh, OPh) [(1)–(5), respectively] was carried out by reversed-phase chiral HPLC on a commercially available Pirkle-type chiral
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Saufi, Ahmad, Cosima B. I. von Heimendahl, A. Wilhelm Alfermann, and Elisabeth Fuss. "Stereochemistry of Lignans in Phaleria macrocarpa (Scheff.) Boerl." Zeitschrift für Naturforschung C 63, no. 1-2 (2008): 13–16. http://dx.doi.org/10.1515/znc-2008-1-203.

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Phaleria macrocarpa (Scheff.) Boerl., a member of the Thymelaeaceae, is traditionally used in Indonesia as medicinal plant against cancer. In this context, we isolated the lignans pinoresinol, lariciresinol and matairesinol from different parts of this plant. The enantiomeric composition of these lignans was determined by chiral column analysis. Pinoresinol and lariciresinol were mixtures of both enantiomers with (79 ± 4)% and (55 ± 6)% enantiomeric excess for the (−)-enantiomers, respectively, whereas matairesinol was found as pure (+)-enantiomer.
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Wang, Peng, Donghui Liu, Xu Gu, Shuren Jiang, and Zhiqiang Zhou. "Quantitative Analysis of Three Chiral Pesticide Enantiomers by High-Performance Column Liquid Chromatography." Journal of AOAC INTERNATIONAL 91, no. 5 (2008): 1007–12. http://dx.doi.org/10.1093/jaoac/91.5.1007.

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Abstract Methods for the enantiomeric quantitative determination of 3 chiral pesticides, paclobutrazol, myclobutanil, and uniconazole, and their residues in soil and water are reported. An effective chiral high-performance liquid chromatographic (HPLC)-UV method using an amylose-tris(3,5-dimethylphenylcarbamate; AD) column was developed for resolving the enantiomers and quantitative determination. The enantiomers were identified by a circular dichroism detector. Validation involved complete resolution of each of the 2 enantiomers, plus determination of linearity, precision, and limit of detect
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Costa, Ana Rita, Virgínia M. F. Gonçalves, Bruno B. Castro, et al. "Toxicity of the 3,4-Methylenedioxymethamphetamine and Its Enantiomers to Daphnia magna after Isolation by Semipreparative Chromatography." Molecules 28, no. 3 (2023): 1457. http://dx.doi.org/10.3390/molecules28031457.

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MDMA (3,4-methylenedioxymethamphetamine) is a chiral psychoactive recreational drug sold in illicit markets as racemate. Studies on the impact of MDMA on aquatic organisms are scarce. While enantioselectivity in toxicity in animals and humans has been reported, none is reported on aquatic organisms. This study aimed to investigate the ecotoxicological effects of MDMA and its enantiomers in Daphnia magna. For that, enantiomers (enantiomeric purity > 97%) were separated by liquid chromatography using a homemade semipreparative chiral column. Daphnids were exposed to three concentrations of (R
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Dutta, Soham, and Andrew J. Gellman. "2D Ising Model for Enantiomer Adsorption on Achiral Surfaces: L- and D-Aspartic Acid on Cu(111)." Entropy 24, no. 4 (2022): 565. http://dx.doi.org/10.3390/e24040565.

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The 2D Ising model is well-formulated to address problems in adsorption thermodynamics. It is particularly well-suited to describing the adsorption isotherms predicting the surface enantiomeric excess, ees, observed during competitive co-adsorption of enantiomers onto achiral surfaces. Herein, we make the direct one-to-one correspondence between the 2D Ising model Hamiltonian and the Hamiltonian used to describe competitive enantiomer adsorption on achiral surfaces. We then demonstrate that adsorption from racemic mixtures of enantiomers and adsorption of prochiral molecules are directly analo
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Tok, Kenan Can, Mehmet Gumustas, Giorgi Jibuti, Halit Sinan Suzen, Sibel A. Ozkan, and Bezhan Chankvetadze. "The Effect of Enantiomer Elution Order on the Determination of Minor Enantiomeric Impurity in Ketoprofen and Enantiomeric Purity Evaluation of Commercially Available Dexketoprofen Formulations." Molecules 25, no. 24 (2020): 5865. http://dx.doi.org/10.3390/molecules25245865.

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In a recent study, opposite enantiomer elution order was observed for ketoprofen enantiomers on two amylose-phenylcarbamate-based chiral columns with the same chemical composition of the chiral selector but in one case with coated while in the other with an immobilized chiral selector. In the present study, the influence of this uncommon effect on method validation parameters for the determination of minor enantiomeric impurity in dexketoprofen was studied. The validated methods with two alternative elution orders for enantiomers were applied for the evaluation of enantiomeric impurity in six
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León-González, María Eugenia, and Noelia Rosales-Conrado. "Enantioselective determination of ibuprofen residues by chiral liquid chromatography: a systematic study of enantiomeric transformation in surface water and sediments." Environmental Chemistry 13, no. 4 (2016): 656. http://dx.doi.org/10.1071/en15146.

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Environmental context Ibuprofen, a common anti-inflammatory drug and one of many pharmaceuticals sold as a mixture of enantiomers, has recently been found in river and surface waters. There are, however, few analytical methods able to separate and accurately measure ibuprofen enantiomers in environmental matrices. This study reports a method for quantifying ibuprofen enantiomers in sediments and surface water, and applies it to shed light on the degradation and fate of the enantiomers in aquatic systems. Abstract The enantioselective composition of ibuprofen in sediments in contact with surfac
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Hocking, Martin B., and Aga Z.-Q. Khan. "Chromatographic enantiomer separation and circular dichroism (CD) spectra of three 4-endosubstituted-3,6-diphenyl-3,6-phenylphosphorylcyclohexenes." Canadian Journal of Chemistry 85, no. 9 (2007): 600–602. http://dx.doi.org/10.1139/v07-088.

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Three enantiomeric pairs of Diels–Alder adducts of 2,5-diphenylphosphole-1-oxide have been resolved by elution of each of the enantiomers with 95% ethanol from a swollen microcrystalline triacetylcellulose stationary phase. The degree of separation achieved in each case was confirmed by comparing the absorbance maximum of the UV spectrum of each separated enantiomer with that of a similar concentration of the relevant racemic mixture. The circular dichroism (CD) spectrum of each of the separated enantiomers was recorded, and spectral parameters are listed.Key words: enantiomer separations, thr
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Dissertations / Theses on the topic "Enantiomers"

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Wildervanck, Alexander Franciscus. "Separation of enantiomers of Baclofen." Master's thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/20462.

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(3-(Aminomethyl)-4-chlorobenzenepropanoic acid (Baclofen), 3-(p-chlorophenyl)pyrrolidone (Baclofen lactam) and 3-(p-Chlorophenyl)glutaramide (baclofen's synthetic precursor) were individually used as substrates in co-crystallisation experiments with several resolving agents. Experiments were conducted in the solid state and in solution. The (-) enantiomer of the lactam and the ( +) enantiomer of the glutaramide were found to cocrystallise selectively with (2R,3R)-( +)-tartaric acid and (S)-(-)-a.-Methylbenzylamine respectively. Both these dissociable diastereomers Vere analysed by X-ray crysta
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Barros, Georgia de Oliveira Figueiredo. "Resolução de misturas racemicas por acoplamento de cristalização a cromatografia em leito movel simulado : estudos fundamentais para a produção de S-cetamina." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267314.

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Orientador: Everson Alves Miranda<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica<br>Made available in DSpace on 2018-08-04T07:13:28Z (GMT). No. of bitstreams: 1 Barros_GeorgiadeOliveiraFigueiredo_M.pdf: 2282903 bytes, checksum: b104323f697a813ec6af57b15ba7b95b (MD5) Previous issue date: 2005<br>Resumo: A separação de enantiômetros em altos níveis de pureza enantiomérica é atualmente um requerimento da industria farmacêutica. No entanto, altas purezas estão sendo alcançadas neste sistema com comprometimento da produtividade. O acoplamento do lei
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Bromley, Graham. "Approaches to single enantiomers of cyclopropanes." Thesis, Cardiff Metropolitan University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409442.

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Anandamanoharan, P. "Isolation of enantiomers via diastereomer crystallisation." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19315/.

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Enantiomer separation remains an important technique for obtaining optically active materials. Even though the enantiomers have identical physical properties, the difference in their biological activities make it important to separate them, in order to use single enantiomer products in the pharmaceutical and fine chemical industries. In this project, the separations of three pairs of diastereomer salts (Fig1) by crystallisation are studied, as examples of the ‘classical’ resolution of enantiomers via conversion to diastereomers. The lattice energies of these diastereomer compounds are calculat
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Zheng, Hui. "Stereoselective pharmacokinetics and metabolism of XK469, a new quinoxaline topoisomerase II beta poison, in the rat." Columbus, Ohio : Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1080257372.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xxi, 190 p.; also includes graphics. Includes abstract and vita. Advisor: Kenneth K. Chan, Dept. of Pharmacy. Includes bibliographical references (p. 182-190).
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Kröner, Dominik. "Theory of selective preparation of enantiomers by laser pulses Theorie zur selektiven Präparation von Enantiomeren durch Laserpulse /." [S.l. : s.n.], 2003. http://www.diss.fu-berlin.de/2003/141/index.html.

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Koza, Gani. "Synthesis of single enantiomers of ketomycolic acids." Thesis, Bangor University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488849.

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Toschi, Gianna. "Synthetic approaches to single enantiomers of mycolic acids." Thesis, Bangor University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429853.

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Brookes, Michael H. "The synthesis of the enantiomers of lipoic acid." Thesis, University of Warwick, 1985. http://wrap.warwick.ac.uk/55428/.

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Lipoic acid is a biologically important molecule. Whilst the racemate has been available by a number of syntheses for many years, no convenient preparation of the pure enantiomers has so far been described. All the evidence so far presented indicates that only the dextrorotatory isomer is active in vivo, the absolute configuration of which has not been established with certainty. To further elucidate the biochemical role(s) and biosynthesis of this compound, a convenient EPC synthesis would be beneficial. This thesis describes the development of a route to the (R)- and (S)- forms of the target
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McBride, John Joseph. "Development of biosensors for the determination of enantiomers." Thesis, University of Brighton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359142.

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Books on the topic "Enantiomers"

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Todd, Matthew, ed. Separation of Enantiomers. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527650880.

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Schurig, Volker, ed. Differentiation of Enantiomers I. Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-03239-9.

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Schurig, Volker, ed. Differentiation of Enantiomers II. Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-03716-5.

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André, Coller, and Wilen Samuel H, eds. Enantiomers, racemates, and resolutions. Krieger Pub. Co., 1991.

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Allenmark, Stig G. Chromatographic enantioseparation: Methods and applications. E. Horwood, 1988.

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Wren, Stephen. The Separation of Enantiomers by Capillary Electrophoresis. Edited by T. A. Berger, K. S. Boos, H. Engelhardt, et al. Vieweg+Teubner Verlag, 2001. http://dx.doi.org/10.1007/978-3-322-83141-5.

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Wren, Stephen. The Separation of Enantiomers by Capillary Electrophoresis. Vieweg+Teubner Verlag, 2001.

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Fumio, Toda, ed. Practical methods of enantiomer separation. Kluwer Academic Publishers, 2004.

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Reid, Eric, Bryan Scales, and Ian D. Wilson, eds. BIOACTIVE ANALYTES, Including CNS Drugs, Peptides, and Enantiomers. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-1892-8.

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Brookes, Michael H. The synthesis of the enantiomers of lipoic acid. [typescript], 1985.

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Book chapters on the topic "Enantiomers"

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Ellenbroek, Bart, Alfonso Abizaid, Shimon Amir, et al. "Enantiomers." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_4233.

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Bada, Jeffrey. "Enantiomers." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_508.

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Uzir, Mohamad Hekarl. "Enantiomers." In Encyclopedia of Membranes. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_2160.

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Bada, Jeffrey. "Enantiomers." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-11274-4_508.

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Uzir, Mohamad Hekarl. "Enantiomers." In Encyclopedia of Membranes. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-40872-4_2160-1.

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Bada, Jeffrey. "Enantiomers." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-65093-6_508.

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Gooch, Jan W. "Enantiomers." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13634.

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Oonk, H. A. J., and I. B. Rietveld. "Enantiomers." In Physical Chemistry in Action. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-68727-4_9.

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Bada, Jeffrey. "Enantiomers." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27833-4_508-2.

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Todd, Matthew. "Introduction: A Survey of How and Why to Separate Enantiomers." In Separation of Enantiomers. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527650880.ch1.

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Conference papers on the topic "Enantiomers"

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Sun, Hongshun, Yunhao Cao, Yusa Chen, et al. "Angle-Multiplexed Terahertz Frequency-Selective Fingerprint Sensor: Broadband Identification of Chiral Enantiomers." In 2025 IEEE 38th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2025. https://doi.org/10.1109/mems61431.2025.10917381.

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Krejčová, Romana, Květoslava Horská, Ivan Votruba, and Antonín Holý. "Phosphorylation of enantiomers of HPMPG." In XIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199902286.

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Pikuta, Elena V., and Richard B. Hoover. "Utilization of alternate chirality enantiomers in microbial communities." In SPIE Optical Engineering + Applications, edited by Richard B. Hoover, Gilbert V. Levin, Alexei Y. Rozanov, and Paul C. W. Davies. SPIE, 2010. http://dx.doi.org/10.1117/12.862232.

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Mayer, N., D. Ayuso, M. Ivanov, and O. Smirnova. "Synthetic chiral vortices for highly-sensitive chiral discrimination." In Frontiers in Optics. Optica Publishing Group, 2022. http://dx.doi.org/10.1364/fio.2022.fm4e.5.

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We combine bicircular vortex beams, creating light that displays chirality in the dipole approximation with azimuthally varying handedness. The chiral vortex leads to a robust and highly-sensitive response in molecular enantiomers with topological properties.
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Huang, Dushu, Wei Liu, Zhaolong Huang, Yashun Chen, Jing Wang, and Na Wu. "Enantioseparation of Enantiomers across Hollow Fiber Supported Liquid Membranes." In 2012 International Conference on Biomedical Engineering and Biotechnology (iCBEB). IEEE, 2012. http://dx.doi.org/10.1109/icbeb.2012.195.

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Huang, Dushu, Wei Liu, Lihua Yao, Yong Min, Ruimin Xiao, and Yashun Chen. "Enantioseparation of Propranolol Enantiomers Using Hollow Fiber Membrane Contactor." In 2012 International Conference on Biomedical Engineering and Biotechnology (iCBEB). IEEE, 2012. http://dx.doi.org/10.1109/icbeb.2012.197.

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Skachilova, Sofya, and Elena Shilova. "POLYMORPH MODIFICATIONS AND OPTICALLY ACTIVE ENANTIOMERS OF DRUGS, PHARMACOTHERAPY." In XV International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m557.sudak.ns2019-15/379-380.

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Chen, Huan, Hui Tang, Xue Ying, Xudong Wu, and Manjing Jia. "The Pharmacokinetics Study of Gossypol-acetate Enantiomers in Rat." In 2012 International Conference on Biomedical Engineering and Biotechnology (iCBEB). IEEE, 2012. http://dx.doi.org/10.1109/icbeb.2012.432.

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Bychkov, Stanislav S., Boris A. Grishanin, and Victor N. Zadkov. "Laser distillation of enantiomers from an isotropic racemic mixture." In International Seminar on Novel Trends in Nonlinear Laser Spectroscopy and High-Precision Measurements in Optics, edited by Sergei N. Bagaev, Victor N. Zadkov, and Sergei M. Arakelian. SPIE, 2001. http://dx.doi.org/10.1117/12.428338.

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Xiao, Ting-Hui, Zhengyi Luo, Kotaro Hiramatsu, et al. "On-chip chiral-field-enhanced Raman optical activity for biosensing." In Conference on Lasers and Electro-Optics/Pacific Rim. Optica Publishing Group, 2022. http://dx.doi.org/10.1364/cleopr.2022.cpdp_06.

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We demonstrate on-chip chiral-field-enhanced Raman optical activity (ROA) by tailoring a dark mode excited in a silicon nanodisk array. We show &gt;100x enhanced chiral light-molecule interaction with negligible artifacts for ROA measurement of biological enantiomers.
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Reports on the topic "Enantiomers"

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Liu, Ying. Chromatographic Separations of Enantiomers and Underivatized Oligosaccharides. Office of Scientific and Technical Information (OSTI), 2004. http://dx.doi.org/10.2172/837283.

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Bae, Sue Y., and Mark D. Winemiller. Separation of VX, RVX and GB Enantiomers Using Liquid ChromatographyTime-of-Flight Mass Spectrometry. Defense Technical Information Center, 2016. http://dx.doi.org/10.21236/ad1002738.

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Ding, Wei Liang. Capillary electrophoresis separation of neutral organic compounds, pharmaceutical drugs, proteins and peptides, enantiomers, and anions. Office of Scientific and Technical Information (OSTI), 1999. http://dx.doi.org/10.2172/350830.

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Nazyrov, Marat, and Yulia Yarkaeva. Enantioselective voltammetric sensor system based on mesoporous carbon black Carbopack X and cyclopentadiene derivatives for determination of clopidogrel enantiomers. Peeref, 2023. http://dx.doi.org/10.54985/peeref.2307p5734071.

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Huszthy, P., J. S. Bradshaw, C. Y. Zhu, T. Wang, and R. M. Izatt. Recognition of the Enantiomers of Chiral Organic Ammonium Salts by Chiral Dibenzyl- and Diphenyl-Substituted Diamido-or Dithionoamidopyridino-18- crown-6 Ligands. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada248026.

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Bradshaw, Jerald S., and Reed M. Izatt. Principles Guiding Enantiomeric Recognition in Macrocycle-Amine Systems. Defense Technical Information Center, 1991. http://dx.doi.org/10.21236/ada234915.

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Bradshaw, J. S., F. Huszthy, C. W. McDaniel, M. Oue, and C. Y. Zhu. Enantiomeric Recognition of Organic Ammonium Salts by Chiral Pyridino- 18-Crown-6 Ligands: A Short Review. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada228546.

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Desai, Meera Jay. Development of Chiral LC-MS Methods for small Molecules and Their Applications in the Analysis of Enantiomeric Composition and Pharmacokinetic Studies. Office of Scientific and Technical Information (OSTI), 2004. http://dx.doi.org/10.2172/837266.

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Joshi, Navalkishore N., Chongsuh Pyun, Verinder K. Mahindroo, Bakthan Singaram, and Herbert C. Brown. Chiral Synthesis via Organoboranes. 33. The Controlled Reaction of B- Alkydiisopinocampheylboranes with Aldehydes Providing a Convenient Procedure for the Enantiomeric Enrichment of the Boronic Ester Products Through Kinetic Resolution. Defense Technical Information Center, 1991. http://dx.doi.org/10.21236/ada238257.

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